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1,020 results on '"Tsioufis, Costas"'

10. Cardiorenal multimorbidity in hospitalized cardiology patients: The Hellenic Cardiorenal Morbidity Snapshot (HECMOS) study

Author

Leontsinis, Ioannis, Farmakis, Dimitrios, Avramidis, Dimitrios, Andrikou, Eirini, Valatsou, Angeliki, Gartzonikas, Elias, Doundoulakis, Ioannis, Zarifis, Ioannis, Karpouzis, Ioannis, Kafkala, Kristalenia, Kouvelas, Nikos, Kourek, Christos, Koufou, Eleni, Kochiadakis, George, Kifnidis, Konstantinos, Liori, Sotiria, Manolis, George, Marketou, Maria, Moschos, Nikitas, Bampatsias, Dimitrios, Bibis, George, Bonou, Maria, Naka, Aikaterini, Davlouros, Periklis, Ntalakouras, Ioannis, Papakonstantinou, Panteleimon Ε., Pappa, Evgenia, Patsilinakos, Sotirios, Plaitis, Aristeidis, Sideris, Antonios, Sideris, Skevos, Skoularigis, John, Stamatelopoulos, Kimon, Stefanou, Garyfallia, Tziakas, Dimitrios, Chatzieleftheriou, Christos, Chrysochoou, Christina, Filippatos, Gerasimos, and Tsioufis, Costas

Published
2023
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18. Left ventricular mass versus pulse wave velocity as predictors of coronary artery disease in hypertensive patients: data from a 6-year-follow-up study

Author

Andrikou, Ioannis, Dimitriadis, Kyriakos, Konstantinidis, Dimitris, Leontsinis, Ioannis, Andrikou, Eirini, Iliakis, Panagiotis, Liatakis, Ioannis, Manta, Eleni, Karaminas, Nikos, Tsioufis, Panagiotis, Magkas, Nikolaos, Georgiopoulos, Georgios, Chrysohoou, Christina, Thomopoulos, Costas, Tousoulis, Dimitrios, and Tsioufis, Costas

Published
2022
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19. Endothelial dysfunction in acute and long standing COVID−19: A prospective cohort study

Author

Oikonomou, Evangelos, Souvaliotis, Nektarios, Lampsas, Stamatios, Siasos, Gerasimos, Poulakou, Garyphallia, Theofilis, Panagiotis, Papaioannou, Theodore G., Haidich, Anna-Bettina, Tsaousi, Georgia, Ntousopoulos, Vasileios, Sakka, Vissaria, Charalambous, Georgios, Rapti, Vasiliki, Raftopoulou, Sylvia, Syrigos, Konstantinos, Tsioufis, Costas, Tousoulis, Dimitris, and Vavuranakis, Manolis

Published
2022
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20. Whispers of the Cath lab: "Cases we would rather forget".

Author

Soulaidopoulos, Stergios, Vlachakis, Panayotis K., Sagris, Marios, Dimitroglou, Yannis, Tolis, Elias, Theofilis, Panagiotis, Aznouridis, Konstantinos, Dimitriadis, Kyriakos, Drakopoulou, Maria, Lozos, Vasileios, Toutouzas, Konstantinos, Aggeli, Constantina, and Tsioufis, Costas

Abstract

In the dynamic field of interventional cardiology, significant strides have been made in reducing periprocedural complications. Echocardiography, particularly transesophageal echocardiography, plays a key role in ensuring the safety and success of structural heart interventions. Its real‐time imaging capabilities allow for precise monitoring of device positioning, deployment, and procedural outcomes. By adhering to established imaging protocols and acquiring standard imaging planes, periprocedural echocardiography has become an essential tool for the successful performance of many structural heart interventions. In this manuscript, we present a series of unusual yet significant complications that we encountered during structural interventional procedures in our catheter laboratory. These complications, detected through echocardiography, underscore the critical role of imaging guidance in recognizing, and addressing unforeseen challenges, such as device malposition, thrombus formation in cardiac chambers during structural heart interventions, and cardiac tamponade during transcatheter mitral valve procedures. Through these cases, we highlight the effectiveness of transesophageal echocardiography in promptly identifying complications, allowing for timely intervention and resolution. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Long-Term Outcomes and Valve Performance in Patients Undergoing Transcatheter Aortic Valve Implantation

Author

Stathogiannis, Konstantinos, Synetos, Andreas, Latsios, George, Karanasos, Antonios, Trantalis, George, Toskas, Pantelis, Drakopoulou, Maria, Xanthopoulou, Maria, Karmpalioti, Maria, Simopoulou, Chryssa, Soulaidopoulos, Stergios, Oikonomou, George, Benetos, Georgios, Tsalamandris, Sotirios, Kosmas, Ilias, Voudris, Vasilis, Mastrokostopoulos, Antonios, Katsimagklis, George, Halvatsiotis, Panos, Deftereos, Spyridon, Tsioufis, Costas, and Toutouzas, Konstantinos

Published
2021
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25. Novel Treatments in Refractory Recurrent Pericarditis.

Author

Lazarou, Emilia, Koutsianas, Christos, Vlachakis, Panayotis K., Theofilis, Panagiotis, Vassilopoulos, Dimitrios, Tsioufis, Costas, Lazaros, George, and Tousoulis, Dimitris

Subjects
INTERLEUKIN-1, MEDICAL care costs, PERICARDITIS, MEDICAL protocols, CANNABIDIOL, INTERLEUKIN-1 receptors
Abstract

Refractory recurrent pericarditis is a troublesome condition that severely impairs the quality of life of affected patients and significantly increases healthcare spending. Until recently, therapeutic options included only a few medications and most of the patients resorted to chronic glucocorticoid treatment with steroid dependence. In the most recent decade, the introduction of interleukin-1 blockers in clinical practice has revolutionized the treatment of glucocorticoid-dependent and colchicine-resistant recurrent pericarditis due to their excellent efficacy and good safety profile. The rationale for the introduction of this class of medications in clinical practice is the autoinflammatory nature of recurrent pericarditis in a substantial rate of cases, with interleukin-1 being the main pro-inflammatory cytokine involved in this context. This review aims to discuss the contemporary available evidence from original research and real-world data on interleukin-1 blocker use in refractory recurrent pericarditis, in terms of indications, mechanism of action, efficacy, side effects, and recommended treatment protocols. Moreover, novel treatment proposals, such as hydroxychloroquine, beta blockers, and cannabidiol, which showed encouraging preliminary results, are addressed. Finally, gaps in knowledge, unmet needs, and future perspectives related to recurrent pericarditis are thoroughly discussed. [ABSTRACT FROM AUTHOR]

Published
2024
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26. The Impact of Dietary Carbohydrates on Inflammation-Related Cardiovascular Disease Risk: The ATTICA Study (2002–2022).

Author

Giannakopoulou, Sofia-Panagiota, Antonopoulou, Smaragdi, Chrysohoou, Christina, Barkas, Fotios, Tsioufis, Costas, Pitsavos, Christos, Liberopoulos, Evangelos, Sfikakis, Petros P., and Panagiotakos, Demosthenes

Abstract

The aim of this study was to evaluate the potential interplay between a carbohydrate diet and inflammation in atherosclerotic cardiovascular disease (ASCVD) development. ATTICA is a prospective observational study of 3042 adults free of cardiovascular disease (CVD) who were recruited in 2002 and followed for 20 years. Baseline data on carbohydrate intake and inflammatory biomarker levels were collected. Participants were stratified by carbohydrate intake (low vs. high: 190 g/day) and carbohydrate quality. At the 20-year follow-up in 2022, 1988 participants had complete data for CVD assessment. The overall quantity and quality of carbohydrate intake did not show a significant association with CVD incidence; inflammatory markers were positively correlated with an increased risk of CVD (p-values < 0.05). Chronic systemic inflammation seems to affect the CVD risk of participants who had a higher carbohydrate intake more substantially, as compared to those with low intake. Additionally, individuals with higher high carbohydrate/low fiber intake experienced a higher risk of inflammation-related CVD, compared to those with high carbohydrate/high fiber intake. The presented findings revealed that the effect of inflammation markers on the CVD risk is influenced both by the amount and quality of carbohydrate intake, irrespective of overall dietary habits and clinical and lifestyle characteristics. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Patent Foramen Ovale Closure in Special Clinical Situations: More Questions Than Answers?

Author

Apostolos, Anastasios, Alexiou, Polyxeni, Papanikolaou, Amalia, Trantalis, Georgios, Drakopoulou, Maria, Ktenopoulos, Nikolaos, Kachrimanidis, Ioannis, Vlachakis, Panayotis K., Tsakiri, Ismini, Chrysostomidis, Grigorios, Aggeli, Konstantina, Tsioufis, Costas, and Toutouzas, Konstantinos

Subjects
PATENT foramen ovale, OLDER patients, ISCHEMIC stroke, DECOMPRESSION sickness, TREATMENT effectiveness, SUMATRIPTAN
Abstract

Patent foramen ovale (PFO) is a remnant of the foetal circulation resulting from incomplete occlusion of the septum primum and septum secundum. Although prevalent in about 25% of the population, it mainly remains asymptomatic. However, its clinical significance in situations such as cryptogenic stroke, migraine, and decompression illness (DCI) has been well described. Recent randomised clinical trials (RCTs) have demonstrated the efficacy of percutaneous PFO closure over pharmacological therapy alone for secondary stroke prevention in carefully selected patients. Notably, these trials have excluded older patients or those with concurrent thrombophilia. Furthermore, the role of closure in other clinical conditions associated with PFO, like decompression sickness (DCS) and migraines, remains under investigation. Our review aims to summarise the existing literature regarding epidemiology, pathophysiological mechanisms, optimal management, and closure indications for these special patient groups. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Resting strain analysis to identify myocardial ischemia in patients with advanced chronic kidney disease.

Author

Tsartsalis, Dimitrios, Dimitroglou, Yannis, Kalompatsou, Argyro, Koukos, Markos, Patsourakos, Dimitrios, Tolis, Elias, Tzoras, Spiros, Petras, Dimitrios, Tsioufis, Costas, and Aggeli, Constantina

Subjects
MYOCARDIAL ischemia, CHRONIC kidney failure, GLOBAL longitudinal strain, STRESS echocardiography, SPECKLE tracking echocardiography
Abstract

Background: Chronic kidney disease (CKD) is associated with higher incidence of cardiovascular death. Screening for coronary artery disease in asymptomatic or mildly symptomatic patients is challenging. Objective: The aim of this study was to investigate the incremental value of resting deformation analysis in predicting positive results for myocardial ischemia during stress transthoracic echocardiography in patients with end‐stage CKD. Methods: Sixty‐one patients (mean age: 62.3 ± 11.8, 65.7% men) with end‐stage CKD were included in the study. Patients underwent a resting transthoracic echocardiogram and a dobutamine stress contrast echo (DSE) protocol. Positive results of DSE were defined as stress‐induced left ventricular (LV) wall motion abnormalities. Results: The study cohort had normal or mildly impaired systolic function: mean LV ejection fraction (EF) was 49.2% (±10.4) and mean LV global longitudinal strain (GLS) was 14.4% (±4.5). Half of our population had impaired left atrial (LA) strain: mean LA reservoir, conduit, and contractile reserve were 24.1% (±12.6), 10.6% (±5.9), and 13.6% (±9.2), respectively. DSE was positive for ischemia in 55.7%. A significant negative association with DSE results was found for LV EF, LV GLS and the conduit phase of LA strain. Both LV and LA dimensions showed positive correlation with presence of ischemia in DSE. Multivariate logistic regression analysis showed that LV GLS was independently associated with DSE (p = 0.007), after controlling for covariates, with high diagnostic accuracy. Conclusion: Resting LV deformation could predict positive results during DSE, thus may be useful to better identify renal patients who might benefit from coronary artery screening. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Mediterranean-Type Diet Adherence and Body Mass Index through 20 Years of Follow-Up: Results from the ATTICA Cohort Study (2002–2022).

Author

Damigou, Evangelia, Georgoulis, Michael, Chrysohoou, Christina, Barkas, Fotios, Vlachopoulou, Elpiniki, Adamidis, Petros S., Kravvariti, Evrydiki, Tsioufis, Costas, Pitsavos, Christos, Liberopoulos, Evangelos, Sfikakis, Petros P., and Panagiotakos, Demosthenes

Abstract

Evidence of the association between dietary habits and long-term body weight status is scarce. This study aimed to evaluate changes in Mediterranean-type diet (MTD) adherence in relation to body weight during 20 years of follow-up. Data from n = 1582 participants from the ATTICA cohort study (2002–2022) were used. MTD adherence was assessed via MedDietScore, and body weight status via body mass index (BMI) by 3 different measurements. We found that MTD adherence and changes in this adherence were inversely related to BMI at 20 years and the mean BMI during the 20-year follow-up. In multi-adjusted linear regression models, a 1/55 increase in baseline, 10-year, and 20-year MedDietScore was associated with a decrease of 0.05–0.13 kg/m2 in BMI at 20 years and of 0.08–0.09 kg/m2 in the mean BMI. Being consistently close to the MTD for 20 years was associated with a >90% decreased risk of maintaining overweight/obesity during the 20-year period. Strong, protective, long-lasting effects of the MTD were observed, even in those who deviated from the MTD in the follow-up (41% of the sample). Our results highlight the need to focus on the overall diet quality to minimize the risk of maintaining an excessive body weight during the life-course. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Efficacy of intravascular lithotripsy (IVL) in coronary stenosis with severe calcification: A multicenter systematic review and meta‐analysis.

Author

Sagris, Marios, Ktenopoulos, Nikolaos, Dimitriadis, Kyriakos, Papanikolaou, Angelos, Tzoumas, Andreas, Terentes‐Printzios, Dimitrios, Synetos, Andreas, Soulaidopoulos, Stergios, Lichtenberg, Michael, Korosoglou, Grigorios, Honton, Benjamin, Tousoulis, Dimitris, Tsioufis, Costas, and Toutouzas, Konstantinos

Published
2024
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37. Long-Term Adherence to the Mediterranean Diet Reduces 20-Year Diabetes Incidence: The ATTICA Cohort Study (2002–2022).

Author

Kechagia, Ioanna, Tsiampalis, Thomas, Damigou, Evangelia, Barkas, Fotios, Anastasiou, Georgia, Kravvariti, Evrydiki, Liberopoulos, Evangelos, Sfikakis, Petros P., Chrysohoou, Christina, Tsioufis, Costas, Pitsavos, Christos, and Panagiotakos, Demosthenes

Subjects
MEDITERRANEAN diet, REDUCING diets, TYPE 2 diabetes, COHORT analysis, DIABETES
Abstract

This study aimed to evaluate the association between adherence to the Mediterranean diet and the 20-year incidence of type II diabetes mellitus (T2DM) among adults from the ATTICA study. This study involved a prospective cohort of 3042 men and women recruited at baseline from the Attica region in Greece. Sociodemographic, anthropometric, lifestyle, and clinical characteristics were evaluated at baseline and follow-up examinations; adherence to the Mediterranean diet was assessed through the MedDietScore (range 0–55); four Mediterranean diet trajectories were identified (i.e., increasing, decreasing, and sustained high and sustained low adherence levels). For the present analysis, data from 2000 individuals with complete information were used (age 43 ± 13 years; 49% men). Over the 20-year period, 26.3% (95%CI 24.4%, 28.3%) of participants developed T2DM; men exhibited a 1.5-times higher incidence compared to women (p < 0.001). Individuals consistently close to the Mediterranean diet throughout the studied period had an improved glycemic and lipidemic profile (at baseline and at 10-y follow-up) (all p-values < 0.001) and showed a 21% reduction in their 20-year risk of developing T2DM compared to those who were consistently away (RR = 0.79, 95%CI 0.47, 0.86). A long-term adherence to the Mediterranean diet is protective against the onset of T2DM and, therefore, could be incorporated in public health actions for the prevention of the disease. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Interleukin-1 Blockers: A Paradigm Shift in the Treatment of Recurrent Pericarditis.

Author

Lazarou, Emilia, Koutsianas, Christos, Theofilis, Panagiotis, Lazaros, George, Vassilopoulos, Dimitrios, Vlachopoulos, Charalambos, Tsioufis, Costas, Imazio, Massimo, Brucato, Antonio, and Tousoulis, Dimitris

Subjects
EMERGENCY room visits, PERICARDITIS, GLUCOCORTICOIDS, INTRAVENOUS immunoglobulins, CLINICAL trials, ANGIOTENSIN-receptor blockers
Abstract

Recurrent pericarditis is a problematic clinical condition that impairs the quality of life of the affected patients due to the need for repeated hospital admissions, emergency department visits, and complications from medications, especially glucocorticoids. Unfortunately, available treatments for recurrent pericarditis are very limited, including only a handful of medications such as aspirin/NSAIDs, glucocorticoids, colchicine, and immunosuppressants (such as interleukin-1 (IL-1) blockers, azathioprine, and intravenous human immunoglobulins). Until recently, the clinical experience with the latter class of medications was very limited. Nevertheless, in the last decade, experience with IL-1 blockers has consistently grown, and valid clinical data have emerged from randomized clinical trials. Accordingly, IL-1 blockers are a typical paradigm shift in the treatment of refractory recurrent pericarditis with a clearly positive cost/benefit ratio for those unfortunate patients with multiple recurrences. A drawback related to the above-mentioned medications is the absence of universally accepted and established treatment protocols regarding the full dose administration period and the need for a tapering protocol for individual medications. Another concern is the need for long-standing treatments, which should be discussed with the patients. The above-mentioned unmet needs are expected to be addressed in the near future, such as further insights into pathophysiology and an individualized approach to affected patients. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Coronary artery calcification, mitral valve calcification and renal function in patients with aortic valve sclerosis

Author

Mavroudeas, Evangelos, Matthaiopoulos, Georgios, Tsiamis, Spyridon, Mantis, Christos, Keramida, Kalliopi, Andrioti, N., Pilarinos, Ioannis, Kliridis, Panagiotis, Nikitopoulos, Dionysios, Benetos, Georgios, Feskou, Eirini, Papagiannis, Georgios, Maragkoudakis, Spyridon, Kafkas, Nikolaos, Tsioufis, Costas, and Toutouzas, Konstantinos

Published
2024
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49. Reply

Author

Thomopoulos, Costas, Bazoukis, George, Tsioufis, Costas, and Mancia, Giuseppe

Published
2020
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