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The article presents a case study of a 67-year-old woman diagnosed with a retroperitoneal ancient schwannoma. She was complaining of faint abdominal discomfort and vaginal hemorrhea. She underwent an abdominal laparotomy with total abdominal hysterectomy and bilateral salpingo-oophorectomy. The article discusses that schwannomas are caused by alteration or absence of the NF2 gene and characterized as calcifications and mixed echogenicity.

PURPOSE: To report a case of granulomatous cheilitis and to emphasize the importance of its diagnosis. MATERIAL/METHODS: A 38 year-old female patient with a disease-free medical history underwent a biopsy of the upper left lip due to a longterm, rapidly growing , painless, recurrent enlargement in the anatomic area for the past two months. The surgical specimen was fi xed in formalin , the samples were embedded in paraffi n blocks and histologic sections were taken and stain with hematoxylin- eosin. RESULTS: Histopathologic examination revealed oral mucosal with small sized epithelioid granulomas without central necrosis with characteristic giant cells of Langhans type and the accompinying presence of lymphocytic infi ltration within swelling stroma. ISTOCHEMICAL STAINS : PAS (-) , Giemsa (-) , Ziehl-Nielsen (-) These fi ndings were not specifi c and suggested the diagnosis of granulomatous cheilitis. CONCLUSION: Granulomatous cheilitis is a rare chronic infl ammatory disease of unknown origin characterized of the swelling of one or both lips. It belongs to a group of diseases known as orophacial granulomatosis in which sarcoidosis , tuberculosis , Crohn disease , Melkersson-Rosenthal syndrome and infectious diseases such as brucellosis are included. Idiopathic granulomatous cheilitis is a diagnosis of exclusion and in order to certify this uncommon entity the full knowledge of the preoperative patients‘ medical history, physical and histological examination and laboratory tests are necessary. [ABSTRACT FROM AUTHOR]

The stroma often fibroepithelial and ten adenomatous cervical polyps, 12 fibro-epithelial vaginal polyps, 20 non neoplastic cervices, 15 cone specimens with CIN changes and five specimens with infiltrative squamous cell carcinoma was investigated. Vimentin, desmin, actin, collagen III, CD34, ER and PgR were studied using the Ventana Automatic Immunostaining System. A subepithelial stromal layer was detected in 17/20 normal specimens, 16/20 cervical polyps, 10/12 vaginal polyps and in 6/15 cone biopsies but not in neoplastic specimens. Vimentin staining was positive in all fibroepithelial polyps, normal specimens and in 6/10 adenomatous polyps. Actin was negative in the loose subepithelial zone but positive in the underlying stroma. Desmin, alpha-1-antitrypsin and CD34 were detected in isolated cells in normal specimens. ER and PgR were observed in isolated subepithelial cells, with greater density in the cells of the fibromuscular wall. In conclusion, loose mesenchymal stroma in the lower female genital tract of a fibrohistiocytic nature was observed with minimal smooth muscle participation--which is the matrix of vaginal and cervical polyps.