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259 results on '"Tsang, Derek S."'

1. Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma

Author

Wang, Justin Z., Patil, Vikas, Landry, Alexander P., Gui, Chloe, Ajisebutu, Andrew, Liu, Jeff, Saarela, Olli, Pugh, Stephanie L., Won, Minhee, Patel, Zeel, Yakubov, Rebeca, Kaloti, Ramneet, Wilson, Christopher, Cohen-Gadol, Aaron, Zaazoue, Mohamed A., Tabatabai, Ghazaleh, Tatagiba, Marcos, Behling, Felix, Almiron Bonnin, Damian A., Holland, Eric C., Kruser, Tim J., Barnholtz-Sloan, Jill S., Sloan, Andrew E., Horbinski, Craig, Chotai, Silky, Chambless, Lola B., Gao, Andrew, Rebchuk, Alexander D., Makarenko, Serge, Yip, Stephen, Sahm, Felix, Maas, Sybren L. N., Tsang, Derek S., Rogers, C. Leland, Aldape, Kenneth, Nassiri, Farshad, and Zadeh, Gelareh

Published
2024
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6. Proton Therapy Mediates Dose Reductions to Brain Structures Associated With Cognition in Children With Medulloblastoma

Author

Sienna, Julianna, Kahalley, Lisa S., Mabbott, Donald, Grosshans, David, Santiago, Anna Theresa, Paulino, Arnold dela Cruz, Merchant, Thomas E., Manzar, Gohar S., Dama, Hitesh, Hodgson, David C., Chintagumpala, Murali, Okcu, Mehmet Fatih, Whitehead, William E., Laperriere, Normand, Ramaswamy, Vijay, Bartels, Ute, Tabori, Uri, Bennett, Julie M., Das, Anirban, Craig, Tim, and Tsang, Derek S.

Published
2024
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10. The Pediatric Proton and Photon Therapy Comparison Cohort: Study Design for a Multicenter Retrospective Cohort to Investigate Subsequent Cancers After Pediatric Radiation Therapy

Author

Berrington de González, Amy, Gibson, Todd M., Lee, Choonsik, Albert, Paul S., Griffin, Keith T., Kitahara, Cari Meinhold, Liu, Danping, Mille, Matthew M., Shin, Jungwook, Bajaj, Benjamin V.M., Flood, Tristin E., Gallotto, Sara L., Paganetti, Harald, Ahmed, Safia K., Eaton, Bree R., Indelicato, Daniel J., Milgrom, Sarah A., Palmer, Joshua D., Baliga, Sujith, Poppe, Matthew M., Tsang, Derek S., Wong, Kenneth, and Yock, Torunn I.

Published
2023
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11. Fractionated radiotherapy for surgically resected intracranial meningiomas: A multicentre retrospective cohort study

Author

Wang, Justin Z., Nassiri, Farshad, Landry, Alexander P, Patil, Vikas, Rebchuk, Alexander, Merali, Zamir A., Gui, Chloe, Lee, Grace, Rogers, Lauren, Sinha, Jessica, Patel, Zeel, Zuccato, Jeffrey A., Voisin, Mathew R., Munoz, David, Spears, Julian, Cusimano, Michael D., Das, Sunit, Makarenko, Serge, Yip, Stephen, Gao, Andrew, Laperriere, Normand, Tsang, Derek S., and Zadeh, Gelareh

Published
2023
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12. A total inverse planning paradigm: Prospective clinical trial evaluating the performance of a novel MR-based 3D-printed head immobilization device

Author

Jablonska, Paola Anna, Parent, Amy, La Macchia, Nancy, Chan, Harley H.L., Filleti, Matthew, Ramotar, Matthew, Cho, Young-Bin, Braganza, Maria, Badzynski, Adam, Laperriere, Normand, Conrad, Tatiana, Tsang, Derek S., Shultz, David, Santiago, Anna, Irish, Jonathan C., Millar, Barbara-Ann, Tadic, Tony, and Berlin, Alejandro

Published
2023
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21. Genomic predictors of response to PD-1 inhibition in children with germline DNA replication repair deficiency

Author

Das, Anirban, Sudhaman, Sumedha, Morgenstern, Daniel, Coblentz, Ailish, Chung, Jiil, Stone, Simone C., Alsafwani, Noor, Liu, Zhihui Amy, Karsaneh, Ola Abu Al, Soleimani, Shirin, Ladany, Hagay, Chen, David, Zatzman, Matthew, Cabric, Vanja, Nobre, Liana, Bianchi, Vanessa, Edwards, Melissa, Sambira Nahum, Lauren C,, Ercan, Ayse B., Nabbi, Arash, Constantini, Shlomi, Dvir, Rina, Yalon-Oren, Michal, Campino, Gadi Abebe, Caspi, Shani, Larouche, Valerie, Reddy, Alyssa, Osborn, Michael, Mason, Gary, Lindhorst, Scott, Bronsema, Annika, Magimairajan, Vanan, Opocher, Enrico, De Mola, Rebecca Loret, Sabel, Magnus, Frojd, Charlotta, Sumerauer, David, Samuel, David, Cole, Kristina, Chiaravalli, Stefano, Massimino, Maura, Tomboc, Patrick, Ziegler, David S., George, Ben, Van Damme, An, Hijiya, Nobuko, Gass, David, McGee, Rose B., Mordechai, Oz, Bowers, Daniel C., Laetsch, Theodore W., Lossos, Alexander, Blumenthal, Deborah T., Sarosiek, Tomasz, Yen, Lee Yi, Knipstein, Jeffrey, Bendel, Anne, Hoffman, Lindsey M., Luna-Fineman, Sandra, Zimmermann, Stefanie, Scheers, Isabelle, Nichols, Kim E., Zapotocky, Michal, Hansford, Jordan R., Maris, John M., Dirks, Peter, Taylor, Michael D., Kulkarni, Abhaya V., Shroff, Manohar, Tsang, Derek S., Villani, Anita, Xu, Wei, Aronson, Melyssa, Durno, Carol, Shlien, Adam, Malkin, David, Getz, Gad, Maruvka, Yosef E., Ohashi, Pamela S., Hawkins, Cynthia, Pugh, Trevor J., Bouffet, Eric, and Tabori, Uri

Published
2022
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22. Radiation Dose Rate, Biologically Effective Dose, and Tumor Characteristics on Local Control and Toxicity After Radiosurgery for Acoustic Neuromas

Author

Villafuerte, Conrad Josef, Shultz, David B., Laperriere, Normand, Gentili, Fred, Heaton, Robert, van Prooijen, Monique, Cusimano, Michael D., Hodaie, Mojgan, Schwartz, Michael, Berlin, Alejandro, Payne, David, Kalia, Suneil K., Bernstein, Mark, Wang, Justin, Zadeh, Gelareh, Spears, Julian, and Tsang, Derek S.

Published
2021
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24. Improving the Pediatric Patient Experience During Radiation Therapy-A Children’s Oncology Group Study

Author

Holt, Douglas E., Hiniker, Susan M., Kalapurakal, John A., Breneman, John C., Shiao, Jay C., Boik, Nicole, Cooper, Benjamin T., Dorn, Paige L., Hall, Matthew D., Logie, Natalie, Lucas, John T., Jr., MacEwan, Iain J., Olson, Adam C., Palmer, Joshua D., Patel, Samir, Pater, Luke E., Surgener, Stephanie, Tsang, Derek S., Vogel, Jennifer H., Wojcik, Alyssa, Wu, Cheng-Chia, and Milgrom, Sarah A.

Published
2021
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30. Long-term neurocognitive and psychological outcomes in meningioma survivors: Individual changes over time and radiation dosimetry.

Author

Sekely, Angela, Zakzanis, Konstantine K, Mabbott, Donald, Tsang, Derek S, Kongkham, Paul, Zadeh, Gelareh, and Edelstein, Kim

Subjects
RADIATION dosimetry, MENINGIOMA, MAGNETIC resonance imaging, COMPUTED tomography, VISUOMOTOR coordination
Abstract

Background This study investigates long-term changes in neurocognitive performance and psychological symptoms in meningioma survivors and associations with radiation dose to circumscribed brain regions. Methods We undertook a retrospective study of meningioma survivors who underwent longitudinal clinical neurocognitive assessments. Change in neurocognitive performance or psychological symptoms was assessed using reliable change indices. Radiation dosimetry, if prescribed, was evaluated based on treatment-planning computerized tomography co-registered with contrast-enhanced 3D T1-weighted magnetic resonance imaging. Mixed effects analyses were used to explore whether incidental radiation to brain regions outside the tumor influences neurocognitive and psychological outcomes. Results Most (range = 41%–93%) survivors demonstrated stable—albeit often below average—neurocognitive and psychological trajectories, although some also exhibited improvements (range = 0%–31%) or declines (range = 0%–36%) over time. Higher radiation dose to the parietal-occipital region (partial R 2 = 0.462) and cerebellum (partial R 2 = 0.276) was independently associated with slower visuomotor processing speed. Higher dose to the hippocampi was associated with increases in depression (partial R 2 = 0.367) and trait anxiety (partial R 2 = 0.236). Conclusions Meningioma survivors experience neurocognitive deficits and psychological symptoms many years after diagnosis, and a proportion of them decline over time. This study offers proof of concept that incidental radiation to brain regions beyond the tumor site may contribute to these sequelae. Future investigations should include radiation dosimetry when examining risk factors that contribute to the quality of survivorship in this growing population. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Proton beam therapy for cancer

Author

Tsang, Derek S. and Patel, Samir

Subjects
Cancer treatment -- Methods, Proton beam radiotherapy -- Usage -- Methods, DNA, Radiotherapy, Tumors, Cancer patients, Health
Abstract

Radiotherapy is a central modality for treatment of cancer in one-third of cancer patients. It is designed to target tumour cells and damage their DNA, while using advanced shaping techniques [...]

Published
2019
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47. Review of 20 years of adult medulloblastoma treatment: Chemotherapy prescription trends and survival.

Author

Sherwood, Marissa, Climans, Seth, Ramos, Ronald, Laperriere, Normand J, Gao, Andrew F, Millar, Barbara-Ann, Shultz, David B, Tsang, Derek S, and Mason, Warren P

Subjects
MEDULLOBLASTOMA, CANCER chemotherapy, KAPLAN-Meier estimator, CANCER relapse, ADULTS
Abstract

Background The historic standard of care for adult medulloblastoma has been considered surgery and radiation, while chemotherapy is increasingly being prescribed. This study reviewed 20-year chemotherapy trends at a high-volume center, as well as overall and progression free-survival. Methods Adults with medulloblastoma treated at an academic center from January 1, 1999 to –December 31, 2020 were reviewed. Patient baseline data were summarized and Kaplan–Meier estimators were used for survival. Results Forty-nine patients were included; median age was 30 years and male: female ratio was 2:1. Desmoplastic and classical histologies were most common. Of all patients, 23 (47%) were high risk and 7 (14%) metastatic at diagnosis. Only 10 (20%) received initial chemotherapy, of which 70% were high risk and 30% metastatic, with most treated from 2010 to 2020. Forty percent of initial chemotherapy patients received salvage chemotherapy for recurrence or metastases (of all patients, 49% required salvage). Initial chemotherapy regimens were mainly cisplatin/lomustine/vincristine, and at recurrence cisplatin/etoposide. Median overall survival was 8.6 years (95% CI 7.5–∞), with 1-, 5-, and 10-year survival at 95.8%, 72%, and 46.7%. Median overall survival for those who did not receive initial chemotherapy was 12.4 years and 7.4 years for those who did (P -value.2). Conclusions Twenty years of adult medulloblastoma treatment was reviewed. Initial chemotherapy patients, most of whom were high risk, trended towards worse survival, but this was nonsignificant. The ideal timing and choice of chemotherapy for adult medulloblastoma is unknown—challenges of administering chemotherapy following photon craniospinal irradiation may have prevented it from becoming routine. [ABSTRACT FROM AUTHOR]

Published
2023
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48. Dosimetric evaluation of adult and paediatric brain tumours planned using mask‐based cobalt‐60 fractionated stereotactic radiotherapy compared to linear accelerator‐based volumetric modulated arc therapy.

Author

Fong, Chin Heng, Heaton, Robert, Liu, Zhihui Amy, Li, Kecheng, van Prooijen, Monique, Cho, Young‐Bin, Shultz, David B., and Tsang, Derek S.

Subjects
VOLUMETRIC-modulated arc therapy, LINEAR accelerators, STEREOTACTIC radiotherapy, BRAIN tumors, MEDICAL dosimetry, RADIOTHERAPY safety, RADIATION exposure, WILCOXON signed-rank test
Abstract

Introduction: We conducted a study to evaluate the dosimetric feasibility of mask‐based cobalt‐60 fractionated stereotactic radiotherapy (mcfSRT) with the Leksell Gamma Knife® Icon™ device. Methods: Eleven patients with intracranial tumours were selected for this dosimetry study. These patients, previously treated with volumetric arc therapy (VMAT), were re‐planned using mcfSRT. Target volume coverage, conformity/gradient indices, doses to organs at risk and treatment times were compared between the mcfSRT and VMAT plans. Two‐sided paired Wilcoxon signed‐rank test was used to compare differences between the two plans. Results: The V95 for PTV was similar between fractionated mcfSRT and VMAT (P = 0.47). The conformity index and gradient indices were 0.9 and 3.3, respectively, for mcfSRT compared to 0.7 and 4.2, respectively, for VMAT (P < 0.001 and 0.004, respectively). The radiation exposure to normal brain was lower for mcfSRT across V10, V25 and V50 compared with VMAT (P = 0.007, <0.001 and <0.001, respectively). The median D0.1cc for optic nerve and chiasm as well as the median D50 to the hippocampi were lower for mcfSRT compared to VMAT. Median beam‐on time for mcfSRT was 9.7 min per fraction, compared to 0.9 min for VMAT (P = 0.002). Conclusion: mcfSRT plans achieve equivalent target volume coverage, improved conformity and gradient indices, and reduced radiation doses to organs at risk as compared with VMAT plans. These results suggest superior dosimetric parameters for mcfSRT plans and can form the basis for future prospective studies. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Neurocognitive impairment, neurobehavioral symptoms, fatigue, sleep disturbance, and depressive symptoms in patients with newly diagnosed glioblastoma.

Author

Sekely, Angela, Bernstein, Lori J, Campbell, Kristin L, Mason, Warren P, Laperriere, Normand, Kalidindi, Navya, Or, Rosemarylin, Ramos, Ronald, Climans, Seth A, Pond, Gregory R, Millar, Barbara Ann, Shultz, David, Tsang, Derek S, Zadeh, Gelareh, and Edelstein, Kim

Subjects
FATIGUE (Physiology), MENTAL depression, SLEEP interruptions, GLIOBLASTOMA multiforme, SYMPTOMS, REGRESSION analysis, VERBAL memory
Abstract

Background In addition to poor survival rates, individuals with glioblastoma (GBM) are at risk of neurocognitive impairment due to multiple factors. This study aimed to characterize neurocognitive impairment, neurobehavioral symptoms, fatigue, sleep disturbance, and depressive symptoms in newly diagnosed GBM patients; and to examine whether neurobehavioral symptoms, fatigue, sleep, and depressive symptoms influence neurocognitive performance. Methods This study was part of a prospective, inception cohort, single-arm exercise intervention in which GBM patients underwent a neuropsychological assessment shortly after diagnosis (median 4 weeks; ie, baseline) and 3, 6, 12, and 18 months later, or until tumor progression. Here, we present baseline data. Forty-five GBM patients (mean age = 55 years) completed objective neurocognitive tests, and self-report measures of neurobehavioral symptoms, fatigue, sleep disturbance, and depressive symptoms. Results Compared to normative samples, GBM patients scored significantly lower on all neurocognitive tests, with 34 (76%) patients exhibiting neurocognitive impairment. Specifically, 53% exhibited impairment in memory retention, 51% in executive function, 42% in immediate recall, 41% in verbal fluency, and 24% in attention. There were high rates of clinically elevated sleep disturbance (70%), fatigue (57%), depressive symptoms (16%), and neurobehavioral symptoms (27%). A multivariate regression analysis revealed that depressive symptoms are significantly associated with neurocognitive impairment. Conclusions GBM patients are vulnerable to adverse outcomes including neurocognitive impairment, neurobehavioral symptoms, fatigue, sleep disturbance, and depressive symptoms shortly after diagnosis, prior to completing chemoradiation. Those with increased depressive symptoms are more likely to demonstrate neurocognitive impairment, highlighting the need for early identification and treatment of depression in this population. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Brain Cancer Progression: A Retrospective Multicenter Comparison of Awake Craniotomy Versus General Anesthesia in High-grade Glioma Resection.

Author

Chowdhury, Tumul, Gray, Kristen, Sharma, Mohit, Mau, Christine, McNutt, Sarah, Ryan, Casey, Farou, Noa, Bergquist, Patrick, Caldwell, Catherine, Uribe, Alberto A., Todeschini, Alexandre B., Bergese, Sergio D., Bucher, Oliver, Musto, Grace, Azazi, Emad Al, Zadeh, Gelareh, Tsang, Derek S., Mansouri, Seyed A., Kakumanu, Saranya, and Venkatraghavan, Lashmi

Published
2022
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