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Vertical Take-Off and Landing (VTOL) based Unmanned Aerial Vehicles (UAV) allow quick, safe, and effective transit of resources from one place to another. Its primary objective is to complete its mission in a short time, thus, making it more useful during emergency cases such as road accidents. A novel design for VTOP UAVs has been proposed in this paper. A mobile application has been created to send and receive commands. The cost estimation and analysis have been carried out for the development and deployment of this device in a real-life scenario. VTOL Unmanned Aerial Vehicles are a novel design for the transportation of medical supplies that aim to significantly increase the flight range and endurance compared to conventional aircraft rotorcraft configurations. The overall conceptual design, modelling and computational simulation of this design are presented.

In the pursuit of sustainable transportation solutions, Electric Vehicles (EVs) have emerged as a promising alternative. This research paper provides an in-depth exploration of the crucial role played by Battery Management Systems (BMS) and conducts a comprehensive comparative analysis of various energy storage technologies for Electric Vehicles. The paper begins by elucidating the intricate components and functions of BMS through an illustrative block diagram, emphasizing its significance in ensuring safe and optimal battery operation. The study then conducts a meticulous analysis of key battery attributes, including energy density, power density, capacity, charge/discharge rates, life cycles, and cost per kWh. Supported by simulated data, the comparative analysis sheds light on the distinct performance characteristics of different battery types - Lithium-ion (Li-Ion), Lithium Iron Phosphate (LiFePO4), Nickel-Metal Hydride (NiMH), and Ultracapacitor. The outcomes offer a comprehensive perspective on their strengths and trade-offs, providing valuable insights for selecting suitable energy storage solutions. By translating intricate technical information into meaningful insights, this research empowers EV industry stakeholders to make informed decisions for enhanced EV performance, economic viability, and sustainable electric mobility.

Waveguide structures have got popularity because of its extensive application in radar system of naval ships and aircrafts. Waveguide models provide high probability of small target detection and reduce rate of false target detection. There are a large number of studies on the waveguide slotted in the wide wall. Researches concerning the narrow wall of the waveguide are much less known. An edge slotted waveguide antenna array based on semicircular end of inclined slots radiating waveguide is proposed. Length of the inclined slot is extended to the adjacent broad wall with semicircular cutting. This extended length increases the resonant length and hence higher gain is obtained. Semicircular cutting at the end of the slot reduces cross-polarization component hence side lobe level obtained are low. Narrow wall inclined slotted waveguide is analyzed and designed to operate in X-band. The radiating slots are etched and rotated alternatively on the broadened top plate with semicircular cutting into the adjacent walls. This technique deletes the radial component of the propagating wave and adds the axial component of the propagating wave. Semicircular cutting increases the resonant length and enhances the gain of the antenna. Designed waveguide structure provides high gain, and cross-polarization component is minimized. Gain of 26 dB is obtained from the simulation results obtained in HFSS (High frequency Software Simulation) and side lobe level obtained is around 20 dB while hardware design provides the gain of 24.5 dB measured on VNA (Vector Network Analyzer) keeping the side lobe level minimum.

Tajindra Singh Saluja,1 Vijay Kumar,2 Monika Agrawal,3 Abhilasha Tripathi,4 Rajesh Kumar Meher,5 Kamini Srivastava,1 Anurag Gupta,1 Anjana Singh,6 Arun Chaturvedi,2 Satyendra Kumar Singh1 1Stem Cell/Cell Culture Unit, Center for Advance Research, King George’s Medical University, Lucknow, Uttar Pradesh, India; 2Department of Surgical Oncology, King George’s Medical University, Lucknow, Uttar Pradesh, India; 3Department of Obstetrics & Gynecology, King George’s Medical University, Lucknow, Uttar Pradesh, India; 4Department of Pharmacology, King George’s Medical University, Lucknow, Uttar Pradesh, India; 5Department of Biotechnology and Bioinformatics, Sambalpur University, Sambalpur, Odisha, India; 6Department of Biochemistry, AIIMS, Rishikesh, Uttarakhand, IndiaCorrespondence: Satyendra Kumar SinghStem Cell/Cell Culture Unit,Center for Advance Research, King George’s Medical University, Lucknow, Uttar Pradesh 226003, IndiaTel +91 9415-204-356Email satyendraks@kgmcindia.eduIntroduction: Despite improved therapeutics in oral squamous cell carcinoma (OSCC), tumor cells that are either quiescent and/or endowed with stem cell–like attributes usually survive treatment and recreate tumor load at relapse. Through this study, we aimed strategically to eliminate these stem cell–like cancer cells using a combination drug approach.Methods: Primary cultures from 15 well–moderately differentiated OSCC were established, and the existence of cancer cells with stem cell–like characteristics using five cancer stem cell (CSC) specific markers — CD44, CD133, CD147, C166, SOX2 and spheroid assay was ascertained. Next, we assessed quiescence in CSCs under normal and growth factor–deprived conditions using Ki67. Among several gene signatures regulating quiescent cellular state, we evaluated the effect of inhibiting Dyrk1b in combination with topoisomerase II and histone deacetylase inhibitors in targeting quiescent CSCs. Multiple drug-effect analysis was carried out with CompuSyn software to determine combination-index values.Results: We observed that CD44+CD133+ showed the highest level of SOX2 expression. CSCs showed varying degrees of quiescence, and inhibition of Dyrk1b decreased quiescence and sensitized CSCs to apoptosis. In the drug-combination study, Dyrk1b inhibitor was combined with topoisomerase II and histone deacetylase inhibitors to target quiescent CSCs. In combination, a synergistic effect was seen even at a 16-fold lower dose than IC50. Furthermore, combined treatment decreased glutathione levels and increased ROS and mitochondrial stress, leading to increased DNA damage and cytochrome c in CSCs.Conclusion: We report marker-based identification of CSC subpopulations and synergy of Dyrk1b inhibitor with topoisomerase II and HDAC inhibitors in primary OSCC. The results provide a new therapeutic strategy to minimize quiescence and target oral CSCs simultaneously.Keywords: oral cancer, cancer stem cells, drug combination, synergy, apoptosis

The renewable energy industry has undergone remarkable growth in recent times, with wind energy assuming a preeminent role as a source of clean energy. Five distinctive geometries were analyzed, including a traditional circular form, a decagonal form, and three sinusoidal forms to evaluate the modal and structural characteristics of vortex bladeless wind turbines. The ANSYS software was employed to carry out both the modal and structural analysis. The vortex bladeless rod was firmly fixed and the mast was exposed to a wind pressure of 15 Pa during modal analysis. The structural analysis was executed to compute the deflection of the vortex bladeless wind turbine under the same wind pressure. The results demonstrated that the sinusoidal forms exhibited the greatest deflection at a wind speed of 5m/s. These findings possess the potential to optimize and augment the design of vortex bladeless wind turbines, provide guidance for future design decisions, and boost the efficiency and dependability of these wind turbines. It is therefore posited that the consideration of diverse geometries in the design of vortex bladeless wind turbines is of paramount importance, and the findings of this study are expected to be of great use to engineers and designers in the wind energy field, thereby catalyzing the progression of this thriving renewable energy source.

This work investigated the relationship of host size, seasons, and water quality parameters with the prevalence and intensity of Cornudiscoides agarwali on Mystus bleekeri collected from the Dikrong River in Arunachal Pradesh, India from February 2016 to January 2017. A total of 2760 specimens of C. agarwali were recovered from 114 individuals of M. bleekeri. The levels of mean intensity, but not the prevalence, of infection of C. agarwali were positively correlated with fish host size, peaking in the largest size class (45.20 ± 5.69 parasites/fish). The prevalence values had a statistically significant seasonal trend, reaching highest (100 %) during the pre-monsoon season, followed by 91.8% during the post-monsoon period and 87.5 % during the monsoon season. The levels of mean intensity of infection were also dependent on the seasons, reaching significantly higher levels during the pre-monsoon season (42.75 ± 4.18 parasites/fish). All water quality parameters measured were within the safety value recommended for freshwater aquaculture. Cornudiscoides agarwali maintained its prevalence above 87.5 % throughout the annual cycle, which means it was able to reproduce year-round in a non-polluted river. This could be an indication of monogenoidean community and population dynamics thriving best under optimum water quality parameters. Also, this article draws the attention of parasitologists and ichthyologists to a taxonomic problem of the misidentification of Mystus spp., and therefore, possibly of their parasitic monogenoids.

We are proud to present this regular issue of the JIWS which addresses a diverse array of Gender Studies topics including lesbian writing, menstruation, abortion, online dating, beauty culture, gender [...]