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2 results on '"Tracey J, Bell"'

1. Polysaccharides from New Zealand Native Plants: A Review of Their Structure, Properties, and Potential Applications

Author

Susan M. Carnachan, Tracey J. Bell, Simon F. R. Hinkley, and Ian M. Sims

Subjects
novel polysaccharide, characterization, rheology, New Zealand, applications, Botany, QK1-989
Abstract

Water-soluble, non-starch polysaccharides from plants are used commercially in a wide range of food and non-food applications. The increasing range of applications for natural polysaccharides means that there is growing demand for plant-derived polysaccharides with different functionalities. The geographical isolation of New Zealand and its unique flora presents opportunities to discover new polysaccharides with novel properties for a range of applications. This review brings together data published since the year 2000 on the composition and structure of exudate gums, mucilages, and storage polysaccharides extracted from New Zealand endemic land plants. The structures and properties of these polysaccharides are compared with the structures of similar polysaccharides from other plants. The current commercial use of these polysaccharides is reviewed and their potential for further exploitation discussed.

Published
2019
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2. Engineering a vascular endothelial growth factor 165-binding heparan sulfate for vascular therapy

Author

Chunming Wang, Huiqing Yeong, Simon M. Cool, Victor Nurcombe, Chuay-Yeng Koo, Selina Poon, Kishore Bhakoo, Simon F.R. Hinkley, Sadasivam Murali, Tracey J. Bell, and Lee Kong Chian School of Medicine (LKCMedicine)

Subjects
Vascular Endothelial Growth Factor A, Angiogenesis, Biophysics, Bioengineering, Biosensing Techniques, Pharmacology, Biology, Protein Engineering, Biomaterials, chemistry.chemical_compound, Vasculogenesis, medicine, Human Umbilical Vein Endothelial Cells, Humans, Vascular Diseases, Cell Proliferation, Tube formation, Cell growth, Heparin, Heparan sulfate, Chorioallantoic membrane, medicine.anatomical_structure, chemistry, Mechanics of Materials, Immunology, Ceramics and Composites, Blood Vessels, Angiogenesis Inducing Agents, Heparitin Sulfate, medicine.drug, Blood vessel, Protein Binding, Signal Transduction
Abstract

The therapeutic use of VEGF165 to stimulate blood vessel formation for the treatment of peripheral arterial disease or cardiovascular-related disease has met with limited success. Here we describe an affinity-isolated heparan sulfate glycotherapeutic (HS7+ve) that binds to, and enhances the bioactivity of, VEGF165. Application of HS7+ve complexed with VEGF165 results in enhanced VEGF165–VEGFR2 interaction, prolonged downstream pErk1/2 signalling, and increased cell proliferation and tube formation in HUVECs, compared with VEGF165 alone. The pro-angiogenic potential of HS7+ve was further assessed in vivo using the chick embryo chorioallantoic membrane (CAM) assay. Exogenous dosing with HS7+ve alone significantly enhanced the formation of new blood vessels with potencies comparable to VEGF165. These results demonstrate the potential for vascular therapy of glycotherapeutic agents targeted at augmenting the bioactivity of VEGF165. ASTAR (Agency for Sci., Tech. and Research, S’pore)

Published
2014

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