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2. An evidence review project for food with function claims ~Challenges of the Japan society for vascular failure for the promotion of adequate evidences for food with function claims

Author

Matsumoto, Chisa, Tomiyama, Hirofumi, Takahashi, Osamu, Maruhashi, Tatsuya, Matsuzawa, Yasushi, Masaki, Nobuyuki, Muraki, Isao, Yano, Yuichiro, Sugimoto, Tadafumi, Kabutoya, Tomoyuki, Sawami, Kosuke, Tanaka, Atsushi, Arima, Hisatomi, Sata, Masataka, and Node, Koichi

Published
2024
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3. The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium

Author

Bruin, Willem B., Abe, Yoshinari, Alonso, Pino, Anticevic, Alan, Backhausen, Lea L., Balachander, Srinivas, Bargallo, Nuria, Batistuzzo, Marcelo C., Benedetti, Francesco, Bertolin Triquell, Sara, Brem, Silvia, Calesella, Federico, Couto, Beatriz, Denys, Damiaan A. J. P., Echevarria, Marco A. N., Eng, Goi Khia, Ferreira, Sónia, Feusner, Jamie D., Grazioplene, Rachael G., Gruner, Patricia, Guo, Joyce Y., Hagen, Kristen, Hansen, Bjarne, Hirano, Yoshiyuki, Hoexter, Marcelo Q., Jahanshad, Neda, Jaspers-Fayer, Fern, Kasprzak, Selina, Kim, Minah, Koch, Kathrin, Bin Kwak, Yoo, Kwon, Jun Soo, Lazaro, Luisa, Li, Chiang-Shan R., Lochner, Christine, Marsh, Rachel, Martínez-Zalacaín, Ignacio, Menchon, Jose M., Moreira, Pedro S., Morgado, Pedro, Nakagawa, Akiko, Nakao, Tomohiro, Narayanaswamy, Janardhanan C., Nurmi, Erika L., Zorrilla, Jose C. Pariente, Piacentini, John, Picó-Pérez, Maria, Piras, Fabrizio, Piras, Federica, Pittenger, Christopher, Reddy, Janardhan Y. C., Rodriguez-Manrique, Daniela, Sakai, Yuki, Shimizu, Eiji, Shivakumar, Venkataram, Simpson, Blair H., Soriano-Mas, Carles, Sousa, Nuno, Spalletta, Gianfranco, Stern, Emily R., Evelyn Stewart, S., Szeszko, Philip R., Tang, Jinsong, Thomopoulos, Sophia I., Thorsen, Anders L., Yoshida, Tokiko, Tomiyama, Hirofumi, Vai, Benedetta, Veer, Ilya M., Venkatasubramanian, Ganesan, Vetter, Nora C., Vriend, Chris, Walitza, Susanne, Waller, Lea, Wang, Zhen, Watanabe, Anri, Wolff, Nicole, Yun, Je-Yeon, Zhao, Qing, van Leeuwen, Wieke A., van Marle, Hein J. F., van de Mortel, Laurens A., van der Straten, Anouk, van der Werf, Ysbrand D., Thompson, Paul M., Stein, Dan J., van den Heuvel, Odile A., and van Wingen, Guido A.

Published
2023
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6. Intermittent hypoxia by obstructive sleep apnea is significantly associated with electro-anatomical remodeling of the left atrium preceding structural remodeling in patients with atrial fibrillation

Author

Takada, Yasuyuki, Shiina, Kazuki, Orihara, Shunichiro, Takata, Yoshifumi, Takahashi, Takamichi, Kani, Junya, Kusume, Takahiro, Terasawa, Muryo, Nakano, Hiroki, Saitoh, Yukio, Yazaki, Yoshinao, Tomiyama, Hirofumi, Chikamori, Taishiro, and Satomi, Kazuhiro

Published
2024
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10. Correction: The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium

Author

Bruin, Willem B., Abe, Yoshinari, Alonso, Pino, Anticevic, Alan, Backhausen, Lea L., Balachander, Srinivas, Bargallo, Nuria, Batistuzzo, Marcelo C., Benedetti, Francesco, Bertolin Triquell, Sara, Brem, Silvia, Calesella, Federico, Couto, Beatriz, Denys, Damiaan A. J. P., Echevarria, Marco A. N., Eng, Goi Khia, Ferreira, Sónia, Feusner, Jamie D., Grazioplene, Rachael G., Gruner, Patricia, Guo, Joyce Y., Hagen, Kristen, Hansen, Bjarne, Hirano, Yoshiyuki, Hoexter, Marcelo Q., Jahanshad, Neda, Jaspers-Fayer, Fern, Kasprzak, Selina, Kim, Minah, Koch, Kathrin, Bin Kwak, Yoo, Kwon, Jun Soo, Lazaro, Luisa, Li, Chiang-Shan R., Lochner, Christine, Marsh, Rachel, Martínez-Zalacaín, Ignacio, Menchon, Jose M., Moreira, Pedro S., Morgado, Pedro, Nakagawa, Akiko, Nakao, Tomohiro, Narayanaswamy, Janardhanan C., Nurmi, Erika L., Zorrilla, Jose C. Pariente, Piacentini, John, Picó-Pérez, Maria, Piras, Fabrizio, Piras, Federica, Pittenger, Christopher, Reddy, Janardhan Y. C., Rodriguez-Manrique, Daniela, Sakai, Yuki, Shimizu, Eiji, Shivakumar, Venkataram, Simpson, Blair H., Soriano-Mas, Carles, Sousa, Nuno, Spalletta, Gianfranco, Stern, Emily R., Evelyn Stewart, S., Szeszko, Philip R., Tang, Jinsong, Thomopoulos, Sophia I., Thorsen, Anders L., Yoshida, Tokiko, Tomiyama, Hirofumi, Vai, Benedetta, Veer, Ilya M., Venkatasubramanian, Ganesan, Vetter, Nora C., Vriend, Chris, Walitza, Susanne, Waller, Lea, Wang, Zhen, Watanabe, Anri, Wolff, Nicole, Yun, Je-Yeon, Zhao, Qing, van Leeuwen, Wieke A., van Marle, Hein J. F., van de Mortel, Laurens A., van der Straten, Anouk, van der Werf, Ysbrand D., Thompson, Paul M., Stein, Dan J., van den Heuvel, Odile A., and van Wingen, Guido A.

Published
2023
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20. Usefulness of the SAGE score to predict elevated values of brachial-ankle pulse wave velocity in Japanese subjects with hypertension

Author

Tomiyama, Hirofumi, Vlachopoulos, Charalambos, Xaplanteris, Panagiotis, Nakano, Hiroki, Shiina, Kazuki, Ishizu, Tomoko, Kohro, Takahide, Higashi, Yukihito, Takase, Bonpei, Suzuki, Toru, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Inoue, Teruo, Koba, Shinji, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Node, Koichi, Tanaka, Atsushi, Maemura, Koji, Ohya, Yusuke, Furukawa, Taiji, Ito, Hiroshi, Ohkuma, Toshiaki, Ninomiya, Toshiharu, Chikamori, Taishiro, Yamashina, Akira, and Ueda, Shin-ichiro

Published
2020
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23. Cross-sectional and longitudinal associations between serum uric acid and endothelial function in subjects with treated hypertension

Author

Tanaka, Atsushi, Kawaguchi, Atsushi, Tomiyama, Hirofumi, Ishizu, Tomoko, Matsumoto, Chisa, Higashi, Yukihito, Takase, Bonpei, Suzuki, Toru, Ueda, Shinichiro, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Inoue, Teruo, Koba, Shinji, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Maemura, Koji, Ohya, Yusuke, Furukawa, Taiji, Ito, Hiroshi, Yamashina, Akira, and Node, Koichi

Published
2018
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26. Ankle-brachial index measured by oscillometry is predictive for cardiovascular disease and premature death in the Japanese population: An individual participant data meta-analysis

Author

Ohkuma, Toshiaki, Ninomiya, Toshiharu, Tomiyama, Hirofumi, Kario, Kazuomi, Hoshide, Satoshi, Kita, Yoshikuni, Inoguchi, Toyoshi, Maeda, Yasutaka, Kohara, Katsuhiko, Tabara, Yasuharu, Nakamura, Motoyuki, Ohkubo, Takayoshi, Watada, Hirotaka, Munakata, Masanori, Ohishi, Mitsuru, Ito, Norihisa, Nakamura, Michinari, Shoji, Tetsuo, Vlachopoulos, Charalambos, Aboyans, Victor, and Yamashina, Akira

Published
2018
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27. Longitudinal association among endothelial function, arterial stiffness and subclinical organ damage in hypertension

Author

Tomiyama, Hirofumi, Ishizu, Tomoko, Kohro, Takahide, Matsumoto, Chisa, Higashi, Yukihito, Takase, Bonpei, Suzuki, Toru, Ueda, Shinichiro, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Inoue, Teruo, Koba, Shinji, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Node, Koichi, Maemura, Koji, Ohya, Yusuke, Furukawa, Taiji, Ito, Hiroshi, and Yamashina, Akira

Published
2018
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28. Brachial artery diameter as a marker for cardiovascular risk assessment: FMD-J study

Author

Maruhashi, Tatsuya, Soga, Junko, Fujimura, Noritaka, Idei, Naomi, Mikami, Shinsuke, Iwamoto, Yumiko, Iwamoto, Akimichi, Kajikawa, Masato, Matsumoto, Takeshi, Oda, Nozomu, Kishimoto, Shinji, Matsui, Shogo, Hashimoto, Haruki, Aibara, Yoshiki, Yusoff, Farina Mohamad, Hidaka, Takayuki, Kihara, Yasuki, Chayama, Kazuaki, Noma, Kensuke, Nakashima, Ayumu, Goto, Chikara, Tomiyama, Hirofumi, Takase, Bonpei, Kohro, Takahide, Suzuki, Toru, Ishizu, Tomoko, Ueda, Shinichiro, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Inoue, Teruo, Koba, Shinji, Watanabe, Kentaro, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Node, Koichi, Maemura, Koji, Ohya, Yusuke, Furukawa, Taiji, Ito, Hiroshi, Ikeda, Hisao, Yamashina, Akira, and Higashi, Yukihito

Published
2018
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29. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019)

Author

Umemura, Satoshi, Arima, Hisatomi, Arima, Shuji, Asayama, Kei, Dohi, Yasuaki, Hirooka, Yoshitaka, Horio, Takeshi, Hoshide, Satoshi, Ikeda, Shunya, Ishimitsu, Toshihiko, Ito, Masaaki, Ito, Sadayoshi, Iwashima, Yoshio, Kai, Hisashi, Kamide, Kei, Kanno, Yoshihiko, Kashihara, Naoki, Kawano, Yuhei, Kikuchi, Toru, Kitamura, Kazuo, Kitazono, Takanari, Kohara, Katsuhiko, Kudo, Masataka, Kumagai, Hiroo, Matsumura, Kiyoshi, Matsuura, Hideo, Miura, Katsuyuki, Mukoyama, Masashi, Nakamura, Satoko, Ohkubo, Takayoshi, Ohya, Yusuke, Okura, Takafumi, Rakugi, Hiromi, Saitoh, Shigeyuki, Shibata, Hirotaka, Shimosawa, Tatsuo, Suzuki, Hiromichi, Takahashi, Shori, Tamura, Kouichi, Tomiyama, Hirofumi, Tsuchihashi, Takuya, Ueda, Shinichiro, Uehara, Yoshinari, Urata, Hidenori, and Hirawa, Nobuhito

Published
2019
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30. High central blood pressure is associated with incident cardiovascular events in treated hypertensives: the ABC-J II Study

Author

Eguchi, Kazuo, Miyashita, Hiroshi, Takenaka, Tsuneo, Tabara, Yasuharu, Tomiyama, Hirofumi, Dohi, Yasuaki, Hashimoto, Junichiro, Ohkubo, Takayoshi, Ohta, Yuko, Hirooka, Yoshitaka, Kohara, Katsuhiko, Ito, Sadayoshi, Kawano, Yuhei, Sunagawa, Kenji, Suzuki, Hiromichi, Imai, Yutaka, Kario, Kazuomi, Takazawa, Kenji, Yamashina, Akira, Shimada, Kazuyuki, and the ABC-J II Investigator Group

Published
2018
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31. Validation of non-invasive central blood pressure devices: Artery society task force (abridged) consensus statement on protocol standardization

Author

Sharman, James E., Avolio, Alberto P., Baulmann, Johannes, Benetos, Athanase, Blacher, Jacques, Blizzard, C. Leigh, Boutouyrie, Pierre, Chen, Chen-Huan, Chowienczyk, Phil, Cockcroft, John R., Cruickshank, J. Kennedy, Ferreira, Isabel, Ghiadoni, Lorenzo, Hughes, Alun, Jankowski, Piotr, Laurent, Stephane, McDonnell, Barry J., McEniery, Carmel, Millasseau, Sandrine C., Papaioannou, Theodoros G., Parati, Gianfranco, Park, Jeong Bae, Protogerou, Athanase D., Roman, Mary J., Schillaci, Giuseppe, Segers, Patrick, Stergiou, George S., Tomiyama, Hirofumi, Townsend, Raymond R., Van Bortel, Luc M., Wang, Jiguang, Wassertheurer, Siegfried, Weber, Thomas, Wilkinson, Ian B., and Vlachopoulos, Charalambos

Published
2017
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34. Endothelial function is impaired in relation to alcohol intake even in the case of light alcohol consumption in Asian men; Flow-mediated Dilation Japan (FMD-J) Study

Author

Oda, Nozomu, Kajikawa, Masato, Maruhashi, Tatsuya, Iwamoto, Yumiko, Kishimoto, Shinji, Matsui, Shogo, Hidaka, Takayuki, Kihara, Yasuki, Chayama, Kazuaki, Goto, Chikara, Aibara, Yoshiki, Nakashima, Ayumu, Noma, Kensuke, Tomiyama, Hirofumi, Takase, Bonpei, Yamashina, Akira, and Higashi, Yukihito

Published
2017
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35. Lifelong Heterogeneous Contribution of Cardiovascular Risk Factors to Slow and Fast Progression of Arterial Stiffness.

Author

Tomiyama, Hirofumi, Imai, Takumi, Shiina, Kazuki, Higashi, Yukihito, Nakano, Hiroki, Takahashi, Takamichi, Fujii, Masatsune, Matsumoto, Chisa, Yamashina, Akira, and Chikamori, Taishiro

Abstract

Background: Although some cardiovascular risk factors (CVRFs) are known to be associated with increased arterial stiffness, increased arterial stiffness does not mediate the cardiovascular risk associated with all CVRFs. Here, based on long-term repeated-measurement data, we examined the association of the lifelong status of each CVRF with the rate of progression of arterial stiffness. Methods: We utilized the data from annual health checkups with the brachial-ankle pulse wave velocity measurements over a 16-year period in middle-aged Japanese occupational cohort. Results: Totally, 29 090 brachial-ankle pulse wave velocity data were obtained during the follow-up of 3763 subjects ranging in age from around 30 to 70 years. Smoking, heavy alcohol intake, hypertension, diabetes, hypertriglyceridemia, and hyperuricemia were independently associated with the fast progression of arterial stiffness. Also, lower values in nondisease range in blood pressure, glycosylated hemoglobin A1c, triglyceride, and uric acid were independently associated with the slow progression of arterial stiffness. For body mass index and low-density lipoprotein cholesterol, no clear associations with the progression of arterial stiffness were observed. Conclusions: The present prospective study provided more robust epidemiological evidence for the heterogeneity of the significance of contribution of lifelong status of each CVRF to the slow and fast rate of progression of arterial stiffness. These findings suggest the important need to examine, in further studies, the effects of global early interventions to control the levels of the culprit CVRFs, even from middle age, not only to prevent a fast progression of the arterial stiffness but also to maintain a relatively slow progression of arterial stiffness. [ABSTRACT FROM AUTHOR]

Published
2023
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36. Steno-Stiffness Approach for Cardiovascular Disease Risk Assessment in Primary Prevention

Author

Tomiyama, Hirofumi, Ohkuma, Toshiaki, Ninomiya, Toshiharu, Mastumoto, Chisa, Kario, Kazuomi, Hoshide, Satoshi, Kita, Yoshikuni, Inoguchi, Toyoshi, Maeda, Yasutaka, Kohara, Katsuhiko, Tabara, Yasuharu, Nakamura, Motoyuki, Ohkubo, Takayoshi, Watada, Hirotaka, Munakata, Masanori, Ohishi, Mitsuru, Ito, Norihisa, Nakamura, Michinari, Shoji, Tetsuo, Vlachopoulos, Charalambos, Aboyans, Victor, and Yamashina, Akira

Published
2019
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38. Physiological Diagnostic Criteria for Vascular Failure

Author

Tanaka, Atsushi, Tomiyama, Hirofumi, Maruhashi, Tatsuya, Matsuzawa, Yasushi, Miyoshi, Toru, Kabutoya, Tomoyuki, Kario, Kazuomi, Sugiyama, Seigo, Munakata, Masanori, Ito, Hiroshi, Ueda, Shinichiro, Vlachopoulos, Charalambos, Higashi, Yukihito, Inoue, Teruo, and Node, Koichi

Published
2018
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40. Global distributions of age- and sex-related arterial stiffness : systematic review and meta-analysis of 167 studies with 509,743 participants

Author

Lu, Yao, Kiechl, Sophia J., Wang, Jie, Xu, Qingbo, Kiechl, Stefan, Pechlaner, Raimund, Aguilar, David, Al-Hashmi, Khamis M., Alvim, Rafael O., Al-Zakwani, Ibrahim S., Antza, Christina, Cicero, Arrigo F.G., Avramovska, Maja, Avramovski, Petar, Baek, Hyun Jae, Bäck, Magnus, Bailey, Kent, Baldo, Marcelo P., Batista, Rosângela F.L., Benetos, Athanasios, Benjamin, Emelia J., Bia, Daniel, Borghi, Claudio, Roux, Shani Botha-Le, Breet, Yolandi, Burgner, David, Cardoso, Viviane C., Cecelja, Marina, Ceponiene, Indre, Chen, Chen-Huan, Cheung, Michael, Cheng, Hao-min, Cho, Jaegeol, Chowienczyk, Phil, Coelho, Eduardo B., Cseprekal, Orsolya, Silva, Amilcar BT Da, Dallaire, Frédéric, Cunha, Roberto De Sá, Diaz, Alejandro, Ferreira, Albano V.L., Ferrières, Jean, Furuta, Yoshihiko, Gómez-Marcos, Manuel A., Gómez-Sánchez, Leticia, Halcox, Julian, Hanis, Craig, Herzig, Karl-Heinz, Jaeggi, Edgar, Kavousi, Maryam, Kiechl-Kohlendorfer, Ursula, Kim, Hack-Lyoung, Kim, Mi-Kyung, Kim, Yu-Mi, Kis, Eva, Knoflach, Michael, Kotsis, Vasilios, Koyama, Teruhide, Kozakova, Michaela, Kruger, Ruan, Kullo, Iftikhar J., Kweon, Sun-Seog, Lambrinoudaki, Irene, Liu, Chang, Loeffler, Markus, Logan, Jeongok G., Maddock, Jane, Magalhães, Pedro, Maldonado, João, Mattace-Raso, Francesco U.S., Messner, Alex, Meyer, Michelle L., Mi, Jie, Mill, José Geraldo, Mitchell, Gary F., Mu, Jian-Jun, Muhammad, Iram F., Nairz, Johannes, Nakagomi, Atsushi, Nakamura, Mieko, Nilson, Peter M., Ninomiya, Toshiharu, Palombo, Carlo, Pereira, Alexandre C., Pereira, Telmo, Capingana, Daniel P., Poon, Anna K., Probst-Hensch, Nicole, Quyyumi, Arshed A., Reusz, George S., Rhee, Moo-Yong, Ribeiro, Cecilia C.C., Rietzschel, Ernst, Rocha, Paulo R.H., Rodilla, Enrique, Rojek, Marta, Ruidavets, Jean-Bernard, Rutten, Joost H.W., Saijo, Yasuaki, Salvi, Paolo, Schmidt-Trucksäss, Arno, Scholz, Markus, Shin, Min-Ho, Segers, Patrick, Stamatelopoulos, Kimon, Strazhesko, Irina D., Sugiura, Minoru, Tkacheva, Olga N., Tomiyama, Hirofumi, Urbina, Elaine M., van den Munckhof, Inge C.L., Vasan, Ramachandran S., Wake, Melissa A., Wannamethee, Goya, Wong, Andrew, Yamashina, Akira, Yan, Yinkun, Zaniqueli, Divanei, Zhu, Fang, Zócalo, Yanina, and Global Pulse Wave Velocity Study Group, on behalf of the

Subjects
Technology and Engineering, Medicine and Health Sciences, General Medicine, General Biochemistry, Genetics and Molecular Biology
Abstract

Background: Arterial stiffening is central to the vascular ageing process and a powerful predictor and cause of diverse vascular pathologies and mortality. We investigated age and sex trajectories, regional differences, and global reference values of arterial stiffness as assessed by pulse wave velocity (PWV). Methods: Measurements of brachial-ankle or carotid-femoral PWV (baPWV or cfPWV) in generally healthy participants published in three electronic databases between database inception and August 24th, 2020 were included, either as individual participant-level or summary data received from collaborators (n = 248,196) or by extraction from published reports (n = 274,629). Quality was appraised using the Joanna Briggs Instrument. Variation in PWV was estimated using mixed-effects meta-regression and Generalized Additive Models for Location, Scale, and Shape. Findings: The search yielded 8920 studies, and 167 studies with 509,743 participants from 34 countries were included. PWV depended on age, sex, and country. Global age-standardised means were 12.5 m/s (95% confidence interval: 12.1–12.8 m/s) for baPWV and 7.45 m/s (95% CI: 7.11–7.79 m/s) for cfPWV. Males had higher global levels than females of 0.77 m/s for baPWV (95% CI: 0.75–0.78 m/s) and 0.35 m/s for cfPWV (95% CI: 0.33–0.37 m/s), but sex differences in baPWV diminished with advancing age. Compared to Europe, baPWV was substantially higher in the Asian region (+1.83 m/s, P = 0.0014), whereas cfPWV was higher in the African region (+0.41 m/s, P < 0.0001) and differed more by country (highest in Poland, Russia, Iceland, France, and China; lowest in Spain, Belgium, Canada, Finland, and Argentina). High vs. other country income was associated with lower baPWV (−0.55 m/s, P = 0.048) and cfPWV (−0.41 m/s, P < 0.0001).Interpretation: China and other Asian countries featured high PWV, which by known associations with central blood pressure and pulse pressure may partly explain higher Asian risk for intracerebral haemorrhage and small vessel stroke. Reference values provided may facilitate use of PWV as a marker of vascular ageing, for prediction of vascular risk and death, and for designing future therapeutic interventions. Funding: This study was supported by the excellence initiative VASCage funded by the Austrian Research Promotion Agency, by the National Science Foundation of China, and the Science and Technology Planning Project of Hunan Province. Detailed funding information is provided as part of the Acknowledgments after the main text.

Published
2023

42. Reliability of measurement of endothelial function across multiple institutions and establishment of reference values in Japanese

Author

Tomiyama, Hirofumi, Kohro, Takahide, Higashi, Yukihito, Takase, Bonpei, Suzuki, Toru, Ishizu, Tomoko, Ueda, Shinichiro, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Inoue, Teruo, Koba, Shinji, Watanabe, Kentaro, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Node, Koichi, Maemura, Koji, Ohya, Yusuke, Furukawa, Taiji, Ito, Hiroshi, Ikeda, Hisao, and Yamashina, Akira

Published
2015
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44. Effect of Saxagliptin on Endothelial Function in Patients with Type 2 Diabetes: A Prospective Multicenter Study

Author

Kajikawa, Masato, Maruhashi, Tatsuya, Hidaka, Takayuki, Matsui, Shogo, Hashimoto, Haruki, Takaeko, Yuji, Nakano, Yukiko, Kurisu, Satoshi, Kihara, Yasuki, Yusoff, Farina Mohamad, Kishimoto, Shinji, Chayama, Kazuaki, Goto, Chikara, Noma, Kensuke, Nakashima, Ayumu, Hiro, Takafumi, Hirayama, Atsushi, Shiina, Kazuki, Tomiyama, Hirofumi, Yagi, Shusuke, Amano, Rie, Yamada, Hirotsugu, Sata, Masataka, and Higashi, Yukihito

Published
2019
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45. Nutritional Status and Sleep Quality Are Associated with Atrial Fibrillation in Patients with Obstructive Sleep Apnea: Results from Tokyo Sleep Heart Study.

Author

Shiina, Kazuki, Takata, Yoshifumi, Takahashi, Takamichi, Kani, Junya, Nakano, Hiroki, Takada, Yasuyuki, Yazaki, Yoshinao, Satomi, Kazuhiro, and Tomiyama, Hirofumi

Abstract

The prevalence of obstructive sleep apnea (OSA) in patients with atrial fibrillation (AF) has been observed to be much higher than in control participants without AF. Limited data exist regarding the prevalence of AF in patients with OSA. The clinical characteristics, nutritional status, and sleep parameters associated with AF in patients with OSA remain unclear. In this study, we aimed to determine the prevalence and factors associated with AF in patients with OSA from a large Japanese sleep cohort (Tokyo Sleep Heart Study). This was a single-center explorative cross-sectional study. Between November 2004 and June 2018, we consecutively recruited 2569 patients with OSA who underwent an overnight full polysomnography at our hospital. They were assessed using a 12-lead ECG and echocardiography. The clinical characteristics, sleep parameters, and medical history were also determined. Of the OSA patients, 169 (6.6%) had AF. Compared with the non-AF patients, OSA patients with AF were older and male, and they had higher prevalence of a history of alcohol consumption, hypertension, chronic kidney disease, and undernutrition, as well as a reduced ejection fraction. With regard to the sleep study parameters, OSA patients with AF had reduced slow-wave sleep and sleep efficiency, as well as higher periodic limb movements. There were no significant differences in the apnea–hypopnea index or hypoxia index between the two groups. The logistic regression analysis demonstrated that age (OR = 4.020; 95% CI: 1.895–8.527; p < 0.001), a history of alcohol consumption (OR = 2.718; 95% CI: 1.461–5.057; p = 0.002), a high CONUT score (OR = 2.129; 95% CI: 1.077–4.209; p = 0.030), and reduced slow-wave sleep (OR = 5.361; 95% CI: 1.505–19.104; p = 0.010) were factors significantly related to AF. The prevalence of AF in patients with OSA was 6.6%. Age, a history of alcohol consumption, undernutrition, and reduced sleep quality were independent risk factors for the presence of AF in patients with OSA, regardless of the severity of OSA. [ABSTRACT FROM AUTHOR]

Published
2023
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46. Reduced reactive hyperemia of the brachial artery in diabetic patients assessed by repeated measurements: The FMD‐J B study.

Author

Masaki, Nobuyuki, Adachi, Takeshi, Tomiyama, Hirofumi, Kohro, Takahide, Suzuki, Toru, Ishizu, Tomoko, Ueda, Shinichiro, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Inoue, Teruo, Koba, Shinji, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Node, Koichi, Maemura, Koji, Ohya, Yusuke, and Furukawa, Taiji

Subjects
BRACHIAL artery, TYPE 2 diabetes, PEOPLE with diabetes, HYPEREMIA, MICROCIRCULATION disorders
Abstract

Type 2 diabetes mellitus (T2DM) is a major cause of microvascular dysfunction. However, its effect on blood flow patterns during ischemic demand has not been adequately elucidated. In this study, we investigated the hypothesis that microvascular dysfunction in patients with T2DM manifests as brachial reactive hyperemia (BRH), defined as the ratio of peak blood flow velocities in a brachial artery before and after forearm cuff occlusion. The study enrolled 943 subjects (men, n = 152 [T2DM] and n = 371 [non‐T2DM]; women, n = 107 [T2DM] and n = 313 [non‐T2DM], respectively) with no history of cardiovascular disease. Semiautomatic measurements were obtained three times at 1.5‐year intervals to confirm the reproducibility of factors involved in BRH for each sex. An age‐adjusted mixed model demonstrated attenuated BRH in the presence of T2DM in both men (p = 0.022) and women (p = 0.031) throughout the study period. Post hoc analysis showed that the estimated BRH was significantly attenuated in patients with T2DM regardless of sex, except at baseline in women. In multivariate regression analysis, T2DM was a negative predictor of BRH at every measurement in men. For women, BRH was more strongly associated with alcohol consumption. Repeated measurements analysis revealed that T2DM was associated with attenuated postocclusion reactive hyperemia. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Endothelial Function Is Impaired in Patients Receiving Antihypertensive Drug Treatment Regardless of Blood Pressure Level: FMD-J Study (Flow-Mediated Dilation Japan)

Author

Maruhashi, Tatsuya, Soga, Junko, Fujimura, Noritaka, Idei, Naomi, Mikami, Shinsuke, Iwamoto, Yumiko, Iwamoto, Akimichi, Kajikawa, Masato, Matsumoto, Takeshi, Oda, Nozomu, Kishimoto, Shinji, Matsui, Shogo, Hashimoto, Haruki, Aibara, Yoshiki, Yusoff, Farina Binti Mohamad, Hidaka, Takayuki, Kihara, Yasuki, Chayama, Kazuaki, Noma, Kensuke, Nakashima, Ayumu, Goto, Chikara, Tomiyama, Hirofumi, Takase, Bonpei, Kohro, Takahide, Suzuki, Toru, Ishizu, Tomoko, Ueda, Shinichiro, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Inoue, Teruo, Koba, Shinji, Watanabe, Kentaro, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Node, Koichi, Maemura, Koji, Ohya, Yusuke, Furukawa, Taiji, Ito, Hiroshi, Ikeda, Hisao, Yamashina, Akira, and Higashi, Yukihito

Published
2017
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