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Abstract Introduction The COVID-19 pandemic in the past few years led to major adjustments in the provision of healthcare. This study aimed to investigate trainees’ perception of impact of the pandemic on specialty training in Obstetrics & Gynaecology (O&G) in Hong Kong. Methods A cross-sectional questionnaire survey was performed on all the O&G trainees and the young fellows of the Hong Kong College of Obstetricians and Gynaecologists (HKCOG). The questionnaires included 5 parts: demographic data, impact on clinical activities, redeployment, educational activities and career progression. Results A total of 104 questionnaires (92.9%) were received for final analysis. The majority of the participants had reductions in elective and emergency operations, as well as exposure to in-patient admissions and out-patient clinics in both obstetrics and gynaecology. The reduction was most significant in elective gynaecology operations. One-third (34.6%) of the participants had been redeployed to other departments, and educational activities were reduced during the pandemic. Around 58% of the trainees were concerned with the reduction in clinical exposure, and 78% worried they would not be able to log sufficient number of surgical procedures. Basic trainees were significantly more worried than higher trainees. Around half of the trainees had doubts or regrets about choosing to undergo O&G specialty training. Conclusion The O&G trainees in Hong Kong perceived that the COVID-19 pandemic had significant negative impacts on their training. Many trainees were worried they would not be able to attain the required level of competence when they complete their specialist training.

Summary: Background: Reducing maternal and perinatal mortality is a global objective. Hong Kong is a city with low maternal and perinatal mortality but little is known about the trend and causes of these deaths in this high-income city. We analyzed the maternal death, stillbirth and neonatal death since 1946 in Hong Kong. Methods: Data were extracted from vital statistics, based on the number of registered deaths and births, provided by the Department of Health, the Government of the HKSAR. The annual change rate of mortality was evaluated by regression analysis. Contextual factors were collected to assess the association with mortality. Findings: Between 1946 and 2017, the stillbirth rate (per 1,000 total births) reduced from 21·5 to 2·4; early and late neonatal deaths (per 1,000 live births) reduced from 14·1 and 18·1 to 0·7 and 0·4 in 2017, respectively. The maternal mortality ratio (per 100,000 live births) declined from 125 to 1·8.The causes of maternal and perinatal deaths were available since 1981 and 1980 respectively. The leading causes of death were thromboembolism (37·0%) and obstetric haemorrhage (30·4%) for maternal death; congenital problem (30·1%) and prematurity (29·0%) for neonatal death. No data on causes of stillbirth were available. No specific shift of pattern was observed in the causes of maternal and neonatal death with time. There were no cases of maternal death due to sepsis and only 2 cases (2·2%) of maternal deaths due to indirect cause. Interpretation: The maternal and perinatal death have reduced significantly in Hong Kong and maintained at the lowest level globally. Indirect maternal death and sepsis were unusual causes of maternal deaths. Use of ICD-PM stillbirth classification, setting up a maternal death confidential enquiry and adding pregnancy checkbox could be the next step to identify and categorize hidden burden. Funding: Nil.

Abstract Background Postpartum haemorrhage from vaginal lacerations can occasionally be refractory to suturing and vaginal packing. Bakri uterine balloon has been widely adopted to stop uterine bleeding, but its use to stop bleeding in vaginal lacerations and its possible complications have seldom been reported. Case presentation We report a patient who had vacuum delivery for fetal distress and subsequently had postpartum hemorrhage due to previous caesarean uterine scar rupture and multiple vaginal lacerations. The severe bleeding persisted despite total abdominal hysterectomy, pelvic embolization and vaginal gauze packing, but was finally controlled by a Bakri balloon tamponade inserted into the vagina. The patient suffered from severe stress incontinence after delivery. The possible use of balloon tamponade in vaginal lacerations and the different types of vaginal balloons that are available in the market for this purpose are reviewed. The possible causes leading to stress incontinence is reported to alert the obstetrician that such management is not free of complications. Conclusion The use of Bakri balloon can help to control bleeding in severe vaginal lacerations that are unresponsive to traditional vaginal gauze packing. Further studies are needed to evaluate the risks of stress incontinence as a possible complication of vaginal balloon tamponade.

Objective: To evaluate the local incidence of orofacial cleft (OFC) encountered in fetal morphology scan and prenatal diagnosis, genetic etiology of fetuses with or without other structural abnormalities, and their pregnancy outcomes. Design: Retrospective cohort study. Setting: Two maternal fetal medicine units, tertiary hospitals, Hong Kong. Participants: All pregnant women with antenatal diagnosis of fetal OFC between January 2016 and December 2020 (N = 66). Results: OFC has an incidence of 0.13% among pregnancies in Hong Kong and 28.8% (19/66) were syndromic cleft that exhibited other fetal structural anomalies. There were 55 cases (84.6%) who opted for invasive prenatal diagnostic testing. Genetic defects were identified in 25.8% (17/66) of this cohort, including 14 pathogenic variants. The detection rate in the syndromic cases is 68.4% (13/19) which was significantly higher than 8.5% (4/47) among non-syndromic cases. Aneuploidies would be the most common cause, accounting for 9.1% (6/66). Chromosomal microarray analysis (CMA) provided an incremental diagnostic yield of 6.1% compared to conventional karyotyping. A total of 29 live births including 3 cases of a variant of uncertain significance and 26 cases without genetic abnormalities detected have continued pregnancy to birth. There were 87.5% (21/24) without detectable pathogenic genetic abnormality reported good long-term outcomes. The chance of OFC fetuses having a good long-term outcome was significantly higher if no genomic variant was detected (P <.001). Conclusions: Invasive prenatal tests with CMA should be offered to pregnancies with OFC regardless of the type. It has provided incremental diagnostic yield over conventional karyotyping and helped in prenatal and genetic counseling. A negative result in non-syndromic OFC favors couples to keep the pregnancy. [ABSTRACT FROM AUTHOR]

Objective: A new ultrasound formula for fetal weight estimation was proposed from the INTERGROWTH-21 project in 2017. There is no comparison of its accuracy with other ultrasound formulae. This study aims to compare the accuracy of INTERGROWTH-21 formula in fetal weight estimation with the traditional Hadlock1 and Shepard formula. Materials and methods: All pregnant patients who had delivery in United Christian Hospital between January to December 2016 were retrospectively reviewed. Those who had prenatal ultrasound scan performed within 7 days of delivery were recruited. Hadlock1, Shepard and INTERGROWTH-21 formula were used to estimate the fetal weight and their accuracies were compared with the actual birthweight of neonates. Results: A total of 403 patients were recruited. Hadlock1 was the most accurate with the lowest mean absolute percentage error (MAPE) 7.34 when compared with Shepard (9.00; p =4000 g) were both associated with significantly higher MAPE in Hadlock1 and INTERGROWTH-21. IUGR (p = 0.005) and macrosomia (p = 0.004) remained significant in the final equation of logistic regression model that affect the precision of fetal weight estimation in Hadlock1, while only IUGR was significant in INTERGROWTH-21 (p

Abstract Background The use of intrauterine balloon tamponade to manage postpartum hemorrhage is increasing. However, there is lack of studies on the menstrual and reproductive outcomes after such treatment. The purpose of this study is to explore the menstrual and reproductive outcomes for patients who had been managed by intrauterine balloon tamponade for severe postpartum hemorrhage in her index pregnancy. Methods All patients who had delivered in United Christian Hospital from January 2011 to June 2016 with severe postpartum hemorrhage (PPH) (blood loss> = 1 L) were identified by the labour ward delivery registry and a comprehensive obstetric database. Patients who had intrauterine balloon tamponade inserted were compared with those managed solely by uterotonic agents as controls. Patients who had hysterectomy or additional procedures performed, such as compression sutures or uterine artery embolization were excluded from both groups. A questionnaire on menses, fertility and reproductive outcomes was mailed to both groups of patients. Those that had not replied within 4 weeks would receive a telephone survey. Results A total of 39 patients in the balloon tamponade group and 161 patients in the control group were recruited, which represented 87.0% of all eligible patients within the study period. The median follow up period was 45 months. All patients in the balloon tamponade group had return of menses after delivery. The majority of the patients (87.2%) in the balloon tamponade group had normal menstrual patterns in the 12 months after the index delivery as well as in the most recent 12 months. After excluding the patients with contraception, the subsequent pregnancy rate was 42.9% (9/21) in the balloon tamponade group compared to 45.9% (28/61) in the control group (p = 0.81). Among the 9 subsequent pregnancies in the balloon tamponade group, there were two miscarriages, one scar pregnancy, one induced abortion, while the remaining five were normal pregnancies with full term deliveries without intrauterine growth restriction. The majority of patients replied that they were satisfied with using Bakri balloon for PPH management in their index pregnancy. Conclusions Intrauterine balloon tamponade for the management of severe PPH appeared to pose little adverse effects on subsequent menstrual and reproductive function.

Background: To obtain the learning curve in determining fetal sex with the first trimester ultrasound scan. Methods: A prospective study was conducted on 400 pregnant patients to determine the fetal sex by ultrasound scan between 11–13+6 weeks of gestation. A midsagittal plane of the fetus was obtained by two sonographers who were newly trained for measuring nuchal translucency. It would be assigned as male if the fetal phallus was in the cranial direction and assigned as female if in caudal direction. The baby sex was confirmed after delivery. The accuracy of each sonographer was analyzed after every 50 ultrasound scans performed. Results: Nearly all the patients requested to be informed about the fetal sex during ultrasound. The accuracy in determining fetal sex by the two sonographers increased with the number of ultrasound scans performed. The two sonographers achieved an accuracy rate of 71.4–78% after 200 ultrasound scans performed. Among different factors which may affect the accuracy in determining fetal sex with ultrasound, a gestational age less than 12 weeks had a significantly lower accuracy than those more than 12 weeks, and male fetuses had significantly higher accuracy than female fetuses. A logistic regression model showed that these two factors remained significant in the equation (p

Background. Intrauterine balloon tamponade (IUBT) and compression sutures have been widely used in recent years in the management of postpartum hemorrhage (PPH). However, there is scant literature directly comparing the clinical scenarios that led to the discriminant selection of these management modalities and the direct clinical outcomes. The purpose of this study is to compare the patient characteristics and clinical risk factors that led to the use of IUBT and compression sutures in the management of major PPH as well as the immediate outcome in a retrospective cohort. Methods. Patients who had IUBT or compression sutures applied due to major PPH (>1000 ml) from 2014 to 2018 in a single obstetric unit were recruited. The patient characteristics and clinical outcome of the two groups were compared. Results. A total of 67 patients had IUBT and 29 patients had compression sutures applied as the first uterine sparing technique. Apart from more vaginal deliveries (25.4% vs. 3.5%) in the IUBT group compared to compression sutures, there were no significant differences between the two groups in terms of patient characteristics. The IUBT group had a slightly higher blood loss at the start of the uterine sparing procedure (239 ml, p = 0:049) and received more transfusions, despite no differences in the total blood loss, hemogloblin level, incidence of coagulopathy, and intensive care unit admission between the two groups. There was no significant difference in the overall success rate between IUBT and compression sutures to control PPH without additional surgical intervention or hysterectomy (73.1% vs. 55.1%, p = 0:15) or the success rate for PPH due to uterine atony (32.8% vs. 20.7%), though IUBT apparently performed better than compression sutures in cases of placenta praevia (77.3% vs. 16.7%, p = 0:01). Blood loss > 1:5 l at the start of the procedure, presence of placenta accreta, and presence of coagulopathy were found to be significant poor prognostic factors for both procedures to control PPH. Conclusions. There were no dominating patient characteristics that favoured the selection of either IUBT or compression sutures in the management of severe PPH except for the mode of delivery. Both procedures had equally high overall success rates to control PPH, but IUBT performed better in placenta praevia cases as compared to compression sutures. [ABSTRACT FROM AUTHOR]

The objective of this study was to evaluate the value of clinical and ultrasound risk factors in predicting severe postpartum haemorrhage (PPH) (≥1.5 L) in pregnancies undergoing caesarean section for placenta praevia. This cohort consists of all cases of placenta praevia undergoing caesarean delivery over a period of 5 years in a service unit. Patients and their delivery data were retrieved from an obstetric database. Ultrasound features were prospectively recorded before caesarean section. The incidence of caesarean section for placenta praevia was 0.98% (n = 215). Of these, 12.1% (n = 26) had severe PPH. A logistic regression model showed that major praevia, antepartum haemorrhage before delivery and anterior placenta remained significant factors associated with severe PPH. The sensitivity/specificity and positive/negative predictive value of the model are 96.2%, 59.8%, 24.8% and 99.1%, respectively. Our model had high sensitivity and negative predictive value for severe PPH during caesarean section for placenta praevia.Impact statementWhat is already known on this subject? Placenta praevia is known to be one of the leading causes of severe PPH. Many risk factors have been associated with severe bleeding during caesarean section for placenta praevia. However, the importance of individual factors in predicting pregnancy outcome remains controversial.What the results of this study add? Our model includes only three simple parameters, namely the presence of significant antepartum haemorrhage (APH) from the history, and anterior or posterior placenta and major or minor praevia from ultrasound findings, but could predict up to 96.2% of all severe PPH. More importantly, the absence of APH, a posterior minor praevia, was associated with a negative predictive value of 99.1% of severe PPH, implying that such cases could be treated as 'normal' low risk caesarean sections.What the implications are of these findings for clinical practice and/or further research? This simple model would allow differential pre-operative counselling of patients on risks and complications, planning and preparation of operation, allocation of staff as well as in contingency measures to be taken during operation. The establishment of a differential protocol for placenta praevia based on these simple risks factors and a prospective trial of such a protocol is suggested. [ABSTRACT FROM AUTHOR]

The aim of this study was to review the indications for caesarean delivery of second twins after vaginal delivery of a first twin (combined delivery) and the associated foetal outcomes of the second twin. Possible factors that could be employed to predict combined delivery were explored. This was a retrospective review of all twin pregnancies delivered in a tertiary maternity unit between 2000 and 2013. All twins (> =24 week gestation) with vaginal delivery of the first twin were reviewed. Of a total of 1039 pairs of twins, 441 pairs had vaginal delivery of the first twin, of which 47 (10.7%) needed combined delivery. Presentation of the second twin was found to be significantly associated with combined delivery (p < .001). The odds ratio for combined delivery for breech second twin was 2.4 compared with vertex second twins while the odds ratio for transverse lie second twin was 182.8. Second twins who were delivered by combined delivery had a higher incidence of 5 min Apgar score <7. The extremely high odds ratio for combined delivery for second twins in transverse lie would probably indicate that attempts at vaginal delivery of these vertex/transverse twin pregnancies would not be worthwhile. Impact statement It remains controversial in the literature whether non-vertex second twins are associated with a higher risk for combined delivery as compared to vertex second twins. Almost all previous studies have analysed the non-vertex second twins as a whole group rather than separating them into breech presentation and transverse lie. There is only one study analysing breech presentation and transverse lie of second twin separately but it has recruited only 14 patients. To our knowledge, the cohort is the largest available dataset comparing the odds ratio for combined delivery of breech and transverse lie of the second twin separately. We found that transverse lie of the second twin have extremely high rates of combined delivery with an odds ratio 182.8 and this may be ascribed to the lack of attempts to perform internal podalic version. Combined delivery is associated with higher maternal and neonatal morbidities. With such a high risk of transverse lie second twin in having combined delivery, it appears reasonable to advise women with vertex/transverse twins not to attempt vaginal delivery unless there are obstetricians who have experience in performing internal podalic version at the time of delivery. This is useful for patient counselling regarding the decision of the mode of delivery. [ABSTRACT FROM AUTHOR]

Background To obtain the learning curve in determining fetal sex with the first trimester ultrasound scan. Methods A prospective study was conducted on 400 pregnant patients to determine the fetal sex by ultrasound scan between 11–13+6 weeks of gestation. A midsagittal plane of the fetus was obtained by two sonographers who were newly trained for measuring nuchal translucency. It would be assigned as male if the fetal phallus was in the cranial direction and assigned as female if in caudal direction. The baby sex was confirmed after delivery. The accuracy of each sonographer was analyzed after every 50 ultrasound scans performed. Results Nearly all the patients requested to be informed about the fetal sex during ultrasound. The accuracy in determining fetal sex by the two sonographers increased with the number of ultrasound scans performed. The two sonographers achieved an accuracy rate of 71.4–78% after 200 ultrasound scans performed. Among different factors which may affect the accuracy in determining fetal sex with ultrasound, a gestational age less than 12 weeks had a significantly lower accuracy than those more than 12 weeks, and male fetuses had significantly higher accuracy than female fetuses. A logistic regression model showed that these two factors remained significant in the equation ( p < 0.001 and p < 0.001). However, prone position of the fetus and maternal obesity significantly decreased the feasibility for sex assignment in both univariate ( p < 0.001 and p = 0.002) and logistic regression analysis ( p < 0.001 and p = 0.012) respectively. Conclusion Around 200 ultrasound scans will need to be performed by a sonographer to achieve an accuracy greater than 70% in determining fetal sex at the first trimester. [ABSTRACT FROM AUTHOR]

Objective: Balloon tamponade has been increasingly used for management of postpartum haemorrhage (PPH). However, follow-up studies on the menstrual and reproductive outcomes after the use of balloon tamponade are minimal. This study aims to explore the subsequent menstrual and reproductive outcomes for patients who had intrauterine balloon tamponade inserted for postpartum haemorrhage in her index pregnancy. Methods: All the pregnant patients who had delivery in United Christian Hospital over a 5-year period from July 2011 to June 2016 with balloon tamponade inserted for PPH were included. Patients who had hysterectomy performed were excluded. A questionnaire on menses, fertility and reproductive outcome was mailed to these patients. Those that did not reply within four weeks would receive a telephone survey by the principal investigator. Patient's data such as parity, gestation, mode of delivery and amount of blood loss will be retrieved from the obstetric electronic database system and clinical case records. Results: A total of 45 patients were recruited for the study, which represented 88% of all eligible patients within the study period. The incidence of normal menstrual function was 97.8%. The median follow up period was 38 months. None of the patients reported secondary subfertility after the index pregnancy, and all conceptions occurred within 12 months from stopping contraception. There were 9 pregnancies reported, including one miscarriage, one scar pregnancy, two induced abortions, and five normal pregnancies with full term deliveries. Two of the deliveries were complicated by recurrent postpartum haemorrhage that was controlled by oxytocins. The majority (95.5%) of patients were satisfied with using Bakri balloon for PPH management in their index pregnancy. Conclusion: Intrauterine balloon tamponade for the management of severe PPH appeared to pose little adverse effects on subsequent menstrual and reproductive function. [ABSTRACT FROM AUTHOR]

Introduction: This study aimed to compare the pregnancy and perinatal outcomes of women with and without severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy., Methods: Women who delivered in an obstetric unit from March 2022 to October 2022 were recruited. The history of vaccination and SARS-CoV-2 infection during pregnancy was recorded. The pregnancy and perinatal outcomes of women with and without SARS-CoV-2 infection were compared., Results: A total of 1015 women were recruited - 41.5% had SARS-CoV-2 infection during pregnancy and 25.2% were unvaccinated. The incidences of preeclampsia, gestational diabetes mellitus and caesarean section were similar between the two groups. There were more preterm deliveries (9.0% vs 5.1%, P = 0.01) and more late preterm deliveries of between 33 and 36 + 6 weeks (6.2% vs. 3.7%, P = 0.03) in the SARS-CoV-2 infection group. There were no statistically significant differences between the two groups in perinatal outcomes, including birthweight, incidence of small for gestational age, low Apgar scores, and neonatal intensive care or special care baby unit admissions. There were no differences in pregnancy and perinatal outcomes between women infected in the first/second trimester and those infected in the third trimester, except for lower mean birthweight (3180 g vs. 3292 g, P = 0.04). There were no major differences in pregnancy outcome between vaccinated and unvaccinated women., Conclusion: The pregnancy and perinatal outcomes of women who were infected with SARS-CoV-2 during gestation appear favourable., (Copyright © 2024 Copyright: © 2024 Singapore Medical Journal.)

Objective: To evaluate the local incidence of orofacial cleft (OFC) encountered in fetal morphology scan and prenatal diagnosis, genetic etiology of fetuses with or without other structural abnormalities, and their pregnancy outcomes., Design: Retrospective cohort study., Setting: Two maternal fetal medicine units, tertiary hospitals, Hong Kong., Participants: All pregnant women with antenatal diagnosis of fetal OFC between January 2016 and December 2020 (N = 66)., Results: OFC has an incidence of 0.13% among pregnancies in Hong Kong and 28.8% (19/66) were syndromic cleft that exhibited other fetal structural anomalies. There were 55 cases (84.6%) who opted for invasive prenatal diagnostic testing. Genetic defects were identified in 25.8% (17/66) of this cohort, including 14 pathogenic variants. The detection rate in the syndromic cases is 68.4% (13/19) which was significantly higher than 8.5% (4/47) among non-syndromic cases. Aneuploidies would be the most common cause, accounting for 9.1% (6/66). Chromosomal microarray analysis (CMA) provided an incremental diagnostic yield of 6.1% compared to conventional karyotyping. A total of 29 live births including 3 cases of a variant of uncertain significance and 26 cases without genetic abnormalities detected have continued pregnancy to birth. There were 87.5% (21/24) without detectable pathogenic genetic abnormality reported good long-term outcomes. The chance of OFC fetuses having a good long-term outcome was significantly higher if no genomic variant was detected ( P  < .001)., Conclusions: Invasive prenatal tests with CMA should be offered to pregnancies with OFC regardless of the type. It has provided incremental diagnostic yield over conventional karyotyping and helped in prenatal and genetic counseling. A negative result in non-syndromic OFC favors couples to keep the pregnancy., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Background: Intrauterine balloon tamponade (IUBT) and compression sutures have been widely used in recent years in the management of postpartum hemorrhage (PPH). However, there is scant literature directly comparing the clinical scenarios that led to the discriminant selection of these management modalities and the direct clinical outcomes. The purpose of this study is to compare the patient characteristics and clinical risk factors that led to the use of IUBT and compression sutures in the management of major PPH as well as the immediate outcome in a retrospective cohort., Methods: Patients who had IUBT or compression sutures applied due to major PPH (>1000 ml) from 2014 to 2018 in a single obstetric unit were recruited. The patient characteristics and clinical outcome of the two groups were compared., Results: A total of 67 patients had IUBT and 29 patients had compression sutures applied as the first uterine sparing technique. Apart from more vaginal deliveries (25.4% vs. 3.5%) in the IUBT group compared to compression sutures, there were no significant differences between the two groups in terms of patient characteristics. The IUBT group had a slightly higher blood loss at the start of the uterine sparing procedure (239 ml, p = 0.049) and received more transfusions, despite no differences in the total blood loss, hemogloblin level, incidence of coagulopathy, and intensive care unit admission between the two groups. There was no significant difference in the overall success rate between IUBT and compression sutures to control PPH without additional surgical intervention or hysterectomy (73.1% vs. 55.1%, p = 0.15) or the success rate for PPH due to uterine atony (32.8% vs. 20.7%), though IUBT apparently performed better than compression sutures in cases of placenta praevia (77.3% vs. 16.7%, p = 0.01). Blood loss > 1.5 l at the start of the procedure, presence of placenta accreta, and presence of coagulopathy were found to be significant poor prognostic factors for both procedures to control PPH., Conclusions: There were no dominating patient characteristics that favoured the selection of either IUBT or compression sutures in the management of severe PPH except for the mode of delivery. Both procedures had equally high overall success rates to control PPH, but IUBT performed better in placenta praevia cases as compared to compression sutures., Competing Interests: The authors declare that there is no conflict of interest regarding the publication of this article., (Copyright © 2021 Choi Wah Kong and William Wing Kee To.)

Objective: A new ultrasound formula for fetal weight estimation was proposed from the INTERGROWTH-21 project in 2017. There is no comparison of its accuracy with other ultrasound formulae. This study aims to compare the accuracy of INTERGROWTH-21 formula in fetal weight estimation with the traditional Hadlock1 and Shepard formula., Materials and Methods: All pregnant patients who had delivery in United Christian Hospital between January to December 2016 were retrospectively reviewed. Those who had prenatal ultrasound scan performed within 7 days of delivery were recruited. Hadlock1, Shepard and INTERGROWTH-21 formula were used to estimate the fetal weight and their accuracies were compared with the actual birthweight of neonates., Results: A total of 403 patients were recruited. Hadlock1 was the most accurate with the lowest mean absolute percentage error (MAPE) 7.34 when compared with Shepard (9.00; p < 0.001) and INTERGROWTH-21 (9.07; p < 0.001). INTERGROWTH-21 had the lowest proportion of patients having estimated fetal weight within 10% discrepancy from the actual birthweight (57.6%) compared with Hadlock1 (71.2%; p < 0.001) and Shepard (66.3; p = 0.011). Presence of intrauterine growth restriction (IUGR) or fetal macrosomia (>=4000 g) were both associated with significantly higher MAPE in Hadlock1 and INTERGROWTH-21. IUGR (p = 0.005) and macrosomia (p = 0.004) remained significant in the final equation of logistic regression model that affect the precision of fetal weight estimation in Hadlock1, while only IUGR was significant in INTERGROWTH-21 (p < 0.001)., Conclusion: INTERGROWTH-21 formula was not shown to be better than the traditional Hadlock1 or Shepard formulae. Future prospective studies would be required to evaluate the accuracy of INTERGROWTH-21 formula especially at the extremes of birthweight., (Copyright © 2019. Published by Elsevier B.V.)