Search

Your search keyword '"Thyssen, Jacob P."' showing total 1,540 results
Start Over Author "Thyssen, Jacob P." Language english
1,540 results on '"Thyssen, Jacob P."'

1. Psoriasis localization patterns in the Swiss Psoriasis Registry (SDNTT) over 11 years: an analysis by sex and age

Author

Birkenmaier, Ion, Maul, Lara Valeska, Oyanguren, Iker, Sorbe, Christina, Fröhlich, Fabienne, Schlapbach, Christoph, Heidemeyer, Kristine, Yawalkar, Nikhil, Boehncke, Wolf-Henning, Ring, Hans-Christian, Thyssen, Jacob P., Egeberg, Alexander, Micheroli, Raphael, Thomsen, Simon Francis, Mainetti, Carlo, Cozzio, Antonio, Kündig, Thomas M., Levesque, Mitchell P., Navarini, Alexander, and Maul, Julia-Tatjana

Published
2024
Full Text
View/download PDF

10. European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation

Author

Budu-Aggrey, Ashley, Kilanowski, Anna, Sobczyk, Maria K., Shringarpure, Suyash S., Mitchell, Ruth, Reis, Kadri, Reigo, Anu, Mägi, Reedik, Nelis, Mari, Tanaka, Nao, Brumpton, Ben M., Thomas, Laurent F., Sole-Navais, Pol, Flatley, Christopher, Espuela-Ortiz, Antonio, Herrera-Luis, Esther, Lominchar, Jesus V. T., Bork-Jensen, Jette, Marenholz, Ingo, Arnau-Soler, Aleix, Jeong, Ayoung, Fawcett, Katherine A., Baurecht, Hansjorg, Rodriguez, Elke, Alves, Alexessander Couto, Kumar, Ashish, Sleiman, Patrick M., Chang, Xiao, Medina-Gomez, Carolina, Hu, Chen, Xu, Cheng-jian, Qi, Cancan, El-Heis, Sarah, Titcombe, Philip, Antoun, Elie, Fadista, João, Wang, Carol A., Thiering, Elisabeth, Wu, Baojun, Kress, Sara, Kothalawala, Dilini M., Kadalayil, Latha, Duan, Jiasong, Zhang, Hongmei, Hadebe, Sabelo, Hoffmann, Thomas, Jorgenson, Eric, Choquet, Hélène, Risch, Neil, Njølstad, Pål, Andreassen, Ole A., Johansson, Stefan, Almqvist, Catarina, Gong, Tong, Ullemar, Vilhelmina, Karlsson, Robert, Magnusson, Patrik K. E., Szwajda, Agnieszka, Burchard, Esteban G., Thyssen, Jacob P., Hansen, Torben, Kårhus, Line L., Dantoft, Thomas M., Jeanrenaud, Alexander C.S.N., Ghauri, Ahla, Arnold, Andreas, Homuth, Georg, Lau, Susanne, Nöthen, Markus M., Hübner, Norbert, Imboden, Medea, Visconti, Alessia, Falchi, Mario, Bataille, Veronique, Hysi, Pirro, Ballardini, Natalia, Boomsma, Dorret I., Hottenga, Jouke J., Müller-Nurasyid, Martina, Ahluwalia, Tarunveer S., Stokholm, Jakob, Chawes, Bo, Schoos, Ann-Marie M., Esplugues, Ana, Bustamante, Mariona, Raby, Benjamin, Arshad, Syed, German, Chris, Esko, Tõnu, Milani, Lili A., Metspalu, Andres, Terao, Chikashi, Abuabara, Katrina, Løset, Mari, Hveem, Kristian, Jacobsson, Bo, Pino-Yanes, Maria, Strachan, David P., Grarup, Niels, Linneberg, Allan, Lee, Young-Ae, Probst-Hensch, Nicole, Weidinger, Stephan, Jarvelin, Marjo-Riitta, Melén, Erik, Hakonarson, Hakon, Irvine, Alan D., Jarvis, Deborah, Nijsten, Tamar, Duijts, Liesbeth, Vonk, Judith M., Koppelmann, Gerard H., Godfrey, Keith M., Barton, Sheila J., Feenstra, Bjarke, Pennell, Craig E., Sly, Peter D., Holt, Patrick G., Williams, L. Keoki, Bisgaard, Hans, Bønnelykke, Klaus, Curtin, John, Simpson, Angela, Murray, Clare, Schikowski, Tamara, Bunyavanich, Supinda, Weiss, Scott T., Holloway, John W., Min, Josine L., Brown, Sara J., Standl, Marie, and Paternoster, Lavinia

Published
2023
Full Text
View/download PDF

20. Reduced Skin Microbiome Diversity in Infancy Is Associated with Increased Risk of Atopic Dermatitis in High-Risk Children

Author

Halling, Anne-Sofie, Fritz, Blaine Gabriel, Gerner, Trine, Rinnov, Maria Rasmussen, Bay, Lene, Knudgaard, Mette Hjorslev, Ravn, Nina Haarup, Trautner, Simon, Ruge, Iben Frier, Olesen, Caroline, Díiaz-Pinées Cort, Isabel, Skov, Lone, Sørensen, Nikolaj, Møller Rønnstad, Amalie Thorsti, Thomsen, Simon F., Egeberg, Alexander, Jakasa, Ivone, Kezic, Sanja, Bjarnsholt, Thomas, and Thyssen, Jacob P.

Published
2023
Full Text
View/download PDF

25. Drug survival of biologics and novel immunomodulators for rheumatoid arthritis, axial spondyloarthritis, psoriatic arthritis, and psoriasis - A nationwide cohort study from the DANBIO and DERMBIO registries

Author

Egeberg, Alexander, Rosenø, Nana Aviaaja Lippert, Thein, David, Lørup, Erik Hillo, Nielsen, Mia-Louise, Nymand, Lea, Kristensen, Lars Erik, Thyssen, Jacob P., Thomsen, Simon Francis, Cordtz, Rene Lindholm, Loft, Nikolai, Skov, Lone, Bryld, Lars Erik, Rasmussen, Mads Kirchheiner, Højgaard, Pil, Kristensen, Salome, and Dreyer, Lene

Published
2022
Full Text
View/download PDF

41. Adult, adolescent, and caregiver preferences for attributes of topical treatments for mild-to-moderate atopic dermatitis: a discrete-choice experiment.

Author

Feldman, Steven R., Thyssen, Jacob P., Boeri, Marco, Gerber, Robert, Neary, Maureen P., Cha, Amy, Hauber, Brett, Cappelleri, Joseph C., Xenakis, Jason, Leach, Colton, and Zeichner, Joshua

Subjects
*CAREGIVERS, *ATOPIC dermatitis, *ADULTS, *PHOSPHODIESTERASE inhibitors, *TEENAGERS
Abstract

Purpose: Topical treatments for mild-to-moderate (MM) atopic dermatitis (AD) include emollients, corticosteroids, calcineurin inhibitors, a Janus kinase inhibitor, and a phosphodiesterase 4 inhibitor, which differ in multiple ways. This study aimed to quantify the conditional relative importance (CRI) of attributes of topical treatments for MM AD among adult and adolescent patients and caregivers of children with MM AD. Materials and methods: A discrete-choice experiment (DCE) survey was administered to US adults and adolescents with MM AD and caregivers of children with MM AD. Each choice task comprised 2 hypothetical topical treatments characterized by efficacy, adverse events, vehicle, and application frequency. Data were analyzed using a random-parameters logit model to calculate the CRI of each attribute. Results and conclusions: 300 adults, 331 adolescents, and 330 caregivers completed the DCE. Avoiding changes in skin color (CRI 29.0) and time until itch improves (26.6) were most important to adults, followed by time until clear/almost clear skin (17.8). Application frequency (3.0) did not have a statistically significant impact on adults’ choices. Adolescents were less concerned about changes in skin color than adults or caregivers; caregivers were less concerned about time until clear/almost clear skin than patients. Physicians should consider age-relevant aspects of preferences in treatment discussions with patients and caregivers. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

46. Subclinical immune responses to nickel in sensitized individuals—a dose–response study.

Author

Wennervaldt, Michael, Vaher, Helen, Ahlström, Malin G., Bischofberger, Nuno, Menné, Torkil, Thyssen, Jacob P., Johansen, Jeanne D., and Bonefeld, Charlotte M.

Abstract

Background: Nickel is the leading cause of contact allergy in Europe, with 14.5% of the adult population being sensitized. Despite regulations limiting nickel release from consumer items, the incidence and prevalence of nickel allergy remain high. Objective: To investigate the clinical and subclinical immune response to low‐dose nickel exposure on nickel pre‐exposed skin to assess the adequacy of current regulatory limits. Method: Nickel‐allergic and healthy controls were patch tested with nickel twice with a 3–4 weeks interval. The first exposure used the diagnostic concentration of 2000 μg/cm2 nickel sulphate, and the same skin areas were then re‐exposed to 0.2, 0.5, 12.8 and 370 μg/cm2 nickel sulphate. After 48 h, the patch reactions were examined for clinical signs of eczema, and skin biopsies were collected. The transcriptomic immune profile was analysed with Nanostring nCounter and quantitative polymerase chain reaction. Results: Two nickel‐allergic participants (15%) had clinical reactions to the regulatory limiting doses for nickel (0.2/0.5 μg/cm2) following re‐exposure. There was immune activation in all skin areas following re‐exposure to nickel, predominantly mediated by up‐regulation of cytokines and chemokines. In all nickel re‐exposed skin areas, 81 genes were up‐regulated independent from the clinical response. In skin areas exposed to 0.2 μg/cm2, 101 immune‐related genes were differentially expressed, even when no clinical response was observed. Healthy controls showed up‐regulation of three genes in response to nickel re‐exposures without any clinical reactions. Conclusion: Immune activation can be induced in skin with local memory to nickel upon challenge with nickel doses within the regulatory limits. Our findings suggest that the regulatory limits in the European nickel regulation may not provide sufficient protection for consumers against low‐dose exposures. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

48. RNA‐sequencing of paired tape‐strips and skin biopsies in atopic dermatitis reveals key differences.

Author

Fritz, Blaine, Halling, Anne‐Sofie, Cort, Isabel Díaz‐Pinés, Christensen, Maria Oberländer, Rønnstad, Amalie Thorsti Møller, Olesen, Caroline Meyer, Knudgaard, Mette Hjorslev, Zachariae, Claus, Heegaard, Steffen, Thyssen, Jacob P., and Bjarnsholt, Thomas

Subjects
SKIN biopsy, ATOPIC dermatitis, LANGERHANS cells, RNA sequencing, GENE expression
Abstract

Background: Skin tape‐strips and biopsies are widely used methods for investigating the skin in atopic dermatitis (AD). Biopsies are more commonly used but can cause scarring and pain, whereas tape‐strips are noninvasive but sample less tissue. The study evaluated the performance of skin tape‐strips and biopsies for studying AD. Methods: Whole‐transcriptome RNA‐sequencing was performed on paired tape‐strips and biopsies collected from lesional and non‐lesional skin from AD patients (n = 7) and non‐AD controls (n = 5). RNA yield, mapping efficiency, and differentially expressed genes (DEGs) for the two methods (tape‐strip/biopsy) and presence of AD (AD/non‐AD) were compared. Results: Tape‐strips demonstrated a lower RNA yield (22 vs. 4596 ng) and mapping efficiency to known genes (28% vs. 93%) than biopsies. Gene‐expression profiles of paired tape‐strips and biopsies demonstrated a medium correlation (R2 = 0.431). Tape‐strips and biopsies demonstrated systematic differences in measured expression levels of 6483 genes across both AD and non‐AD samples. Tape‐strips preferentially detected many itch (CCL3/CCL4/OSM) and immune‐response (CXCL8/IL4/IL5/IL22) genes as well as markers of epidermal dendritic cells (CD1a/CD207), while certain cytokines (IL18/IL37), skin‐barrier genes (KRT2/FLG2), and dermal fibroblasts markers (COL1A/COL3A) were preferentially detected by biopsies. Tape‐strips identified more DEGs between AD and non‐AD (3157 DEGs) then biopsies (44 DEGs). Tape‐strips also detected higher levels of bacterial mRNA than biopsies. Conclusions: This study concludes that tape‐strips and biopsies each demonstrate respective advantages for measuring gene‐expression changes in AD. Thus, the specific skin layers and genes of interest should be considered before selecting either method. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

49. Impact of climate change on atopic dermatitis: A review by the International Eczema Council.

Author

Wang, Sheng‐Pei, Stefanovic, Nicholas, Orfali, Raquel L., Aoki, Valeria, Brown, Sara J., Dhar, Sandipan, Eichenfield, Lawrence F., Flohr, Carsten, Ha, Alex, Mora, Camilo, Murase, Jenny E., Rosenbach, Misha, Srinivas, Sahana M., Thyssen, Jacob P., Wei, Maria L., Irvine, Alan D., and Abuabara, Katrina

Subjects
ATOPIC dermatitis, GREENHOUSE gases, CLIMATE change, ECZEMA, AIR pollution
Abstract

Atopic dermatitis (AD), the most burdensome skin condition worldwide, is influenced by climatic factors and air pollution; however, the impact of increasing climatic hazards on AD remains poorly characterized. Leveraging an existing framework for 10 climatic hazards related to greenhouse gas emissions, we identified 18 studies with evidence for an impact on AD through a systematic search. Most climatic hazards had evidence for aggravation of AD the impact ranged from direct effects like particulate matter‐induced AD exacerbations from wildfires to the potential for indirect effects like drought‐induced food insecurity and migration. We then created maps comparing the past, present, and future projected burden of climatic hazards to global AD prevalence data. Data are lacking, especially from those regions most likely to experience more climatic hazards. We highlight gaps important for future research: understanding the synergistic impacts of climatic hazards on AD, long‐term disease activity, the differential impact on vulnerable populations, and how basic mechanisms explain population‐level trends. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results