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We report on a direct detection differential absorption lidar (DIAL), designed for remote detection of CH4 and CO2. The system is based on a single-frequency optical parametric oscillator/amplifier system, tunable in the 1.57-1.65 µm range. The DIAL system, called NAOMI GAZL, was tested on a controlled gas release facility in October 2018.

International audience; Cancer immunotherapy is seeing an increasing focus on vaccination with tumor-associated antigens (TAAs). Human telomerase (hTERT) is a TAA expressed by most tumors to overcome telomere shortening. Tolerance to hTERT can be easily broken both naturally and experimentally and hTERT DNA vaccine candidates have been introduced in clinical trials. DNA prime/boost strategies have been widely developed to immunize efficiently against infectious diseases. We explored the use of a recombinant measles virus (MV) hTERT vector to boost DNA priming as recombinant live attenuated measles virus has an impressive safety and efficacy record. Here, we show that a MV-TERT vector can rapidly and strongly boost DNA hTERT priming in MV susceptible IFNAR/CD46 mouse models. The cellular immune responses were Th1 polarized. No humoral responses were elicited. The 4 kb hTERT transgene did not impact MV replication or induction of cell-mediated responses. These findings validate the MV-TERT vector to boost cell-mediated responses following DNA priming in humans.

International audience; This paper addresses the problem of critical operations in Degraded Visual Environment (DVE). DVE usually refer when the perception of a pilot is degraded by environmental factors, including the presence of obscurants from bad weather (e.g. fog, rain, snow) or accidental events (e.g. brownout, whiteout, smoke). Critical operations in DVE are a growing field of research as it is a cause of numerous fatal accidents for operational forces. Due to the lack of efficient sources and sensors in the Terahertz (THz) region, this domain has remained an unexplored part of the electromagnetic spectrum. Recently, the potential use of sub-Terahertz waves has been proposed to see through dense clouds of obscurants (e.g. sand, smoke) in DVE conditions. In order to conduct a performance evaluation of sub-Terahertz systems, several sub-terahertz systems (e.g. bolometer- array cameras, liquid helium cooled bolometers) were operated in artificial controlled DVE conditions at ONERA facilities. The purpose of this paper is to report field experiments results in controlled DVE conditions: attenuation measurements from 400 GHz to 700 GHz with a performance evaluation of different sub-Terahertz systems are presented.

International audience; The background scene generator MATISSE, whose main functionality is to generate natural background radiance images, makes use of the so-called Correlated K (CK) model. It necessitates either to load or to compute thousands of CK coefficients for each atmospheric profile. When the CK coefficients cannot be loaded, the computation time becomes prohibitive. The idea developed in this paper is to substitute fast approximate models to the exact CK generator: using the latter, a representative set of numerical examples is built and used to train linear or nonlinear regression models. The resulting models enable an accurate CK coefficient computation for all the profiles of an image in a reasonable time.