Search

Your search keyword '"Theodore, Nicholas"' showing total 887 results
Start Over Author "Theodore, Nicholas" Language english
887 results on '"Theodore, Nicholas"'

6. Early versus late surgical decompression for patients with acute traumatic central cord syndrome: a systematic review and meta-analysis

Author

Sattari, Shahab Aldin, Antar, Albert, Theodore, John N., Hersh, Andrew M., Al-Mistarehi, Abdel-Hameed, Davidar, A. Daniel, Weber-Levine, Carly, Azad, Tej D., Yang, Wuyang, Feghali, James, Xu, Risheng, Manbachi, Amir, Lubelski, Daniel, Bettegowda, Chetan, Chang, Louis, Witham, Timothy, Belzberg, Allan, and Theodore, Nicholas

Published
2024
Full Text
View/download PDF

12. Tethered spinal cord tension assessed via ultrasound elastography in computational and intraoperative human studies

Author

Kerensky, Max J., Paul, Abhijit, Routkevitch, Denis, Hersh, Andrew M., Kempski Leadingham, Kelley M., Davidar, A. Daniel, Judy, Brendan F., Punnoose, Joshua, Williams, Autumn, Kumar, Avisha, Lehner, Kurt, Smith, Beth, Son, Jennifer K., Azadi, Javad R., Shekhar, Himanshu, Mercado-Shekhar, Karla P., Thakor, Nitish V., Theodore, Nicholas, and Manbachi, Amir

Published
2024
Full Text
View/download PDF

26. Antiresorptive Medications Prior to Stereotactic Body Radiotherapy for Spinal Metastasis are Associated with Reduced Incidence of Vertebral Body Compression Fracture.

Author

Patel, Palak P., Esposito, Edward P., Zhu, Jiafeng, Chen, Xuguang, Khan, Majid, Kleinberg, Lawrence, Lubelski, Daniel, Theodore, Nicholas, Lo, Sheng-fu Larry, Hun Lee, Sang, Kebaish, Khaled, Bydon, Ali, and Redmond, Kristin J.

Subjects
VERTEBRAL fractures, STEREOTACTIC radiotherapy, VERTEBRAE injuries, BONE metastasis, DRUGS, METASTASIS
Abstract

Study Design: Retrospective Cohort Objective: Antiresorptive drugs are often given to minimize fracture risk for bone metastases, but data regarding optimal time or ability to reduce stereotactic body radiotherapy (SBRT)-induced fracture risk is limited. This study examines the association between antiresorptive use surrounding spinal SBRT and vertebral compression fracture (VCF) incidence to provide information regarding effectiveness and optimal timing of use. Methods: Patients treated with SBRT for spinal metastases at a single institution between 2009-2020 were included. Kaplan-Meier analysis was used to compare cumulative incidence of VCF for those taking antiresorptive drugs pre-SBRT, post-SBRT only, and none at all. Cox proportional hazards and Fine-Gray competing risk models were used to identify additional factors associated with VCF. Results: Of the 234 patients (410 vertebrae) analyzed, 49 (20.9%) were taking bisphosphonates alone, 42 (17.9%) were taking denosumab alone, and 25 (10.7%) were taking both. Kaplan-Meier analysis revealed a statistically significant lower VCF incidence for patients initiating antiresorptive drugs before SBRT compared to those taking none at all (4% vs 12% at 1 year post-SBRT, P =.045; and 4% vs 23% at 2 years, P =.008). On multivariate analysis, denosumab duration (HR:.87, P =.378) or dose (HR: 1.00, P =.644) as well as bisphosphonate duration (HR:.98, P =.739) or dose (HR:.99, P =.741) did not have statistical significance on VCF incidence. Conclusion: Initiating antiresorptive agents before SBRT may reduce the risk of treatment-induced VCF. Antiresorptive drugs are underutilized in patients with spine metastases and may represent a useful intervention to minimize toxicity and improve long-term outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

35. Fully automatic online geometric calibration for non‐circular cone‐beam CT orbits using fiducials with unknown placement.

Author

Ma, Yiqun Q., Reynolds, Tess, Ehtiati, Tina, Weiss, Clifford, Hong, Kelvin, Theodore, Nicholas, Gang, Grace J., and Stayman, J. Webster

Subjects
CONE beam computed tomography, ORBITS (Astronomy), CALIBRATION, THREE-dimensional imaging, SPATIAL resolution
Abstract

Background: Cone‐beam CT (CBCT) with non‐circular scanning orbits can improve image quality for 3D intraoperative image guidance. However, geometric calibration of such scans can be challenging. Existing methods typically require a prior image, specialized phantoms, presumed repeatable orbits, or long computation time. Purpose: We propose a novel fully automatic online geometric calibration algorithm that does not require prior knowledge of fiducial configuration. The algorithm is fast, accurate, and can accommodate arbitrary scanning orbits and fiducial configurations. Methods: The algorithm uses an automatic initialization process to eliminate human intervention in fiducial localization and an iterative refinement process to ensure robustness and accuracy. We provide a detailed explanation and implementation of the proposed algorithm. Physical experiments on a lab test bench and a clinical robotic C‐arm scanner were conducted to evaluate spatial resolution performance and robustness under realistic constraints. Results: Qualitative and quantitative results from the physical experiments demonstrate high accuracy, efficiency, and robustness of the proposed method. The spatial resolution performance matched that of our existing benchmark method, which used a 3D‐2D registration‐based geometric calibration algorithm. Conclusions: We have demonstrated an automatic online geometric calibration method that delivers high spatial resolution and robustness performance. This methodology enables arbitrary scan trajectories and should facilitate translation of such acquisition methods in a clinical setting. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

37. Scoring System to Triage Patients for Spine Surgery in the Setting of Limited Resources: Application to the Coronavirus Disease 2019 (COVID-19) Pandemic and Beyond

Author

Sciubba, Daniel M., Ehresman, Jeff, Pennington, Zach, Lubelski, Daniel, Feghali, James, Bydon, Ali, Chou, Dean, Elder, Benjamin D., Elsamadicy, Aladine A., Goodwin, C. Rory, Goodwin, Matthew L., Harrop, James, Klineberg, Eric O., Laufer, Ilya, Lo, Sheng-Fu L., Neuman, Brian J., Passias, Peter G., Protopsaltis, Themistocles, Shin, John H., Theodore, Nicholas, Witham, Timothy F., and Benzel, Edward C.

Published
2020
Full Text
View/download PDF

49. A future blood test for acute traumatic spinal cord injury.

Author

Azad, Tej D., Ran, Kathleen R., Liu, Jiaqi, Vattipally, Vikas N., Khela, Harmon, Leite, Enzo, Materi, Joshua D., Davidar, A. Daniel, Bettegowda, Chetan, and Theodore, Nicholas

Subjects
SPINAL cord injuries, BLOOD testing, MAGNETIC resonance imaging, CELL-free DNA, POLYMERASE chain reaction
Abstract

Acute spinal cord injury (SCI) requires prompt diagnosis and intervention to minimize the risk of permanent neurologic deficit. Presently, SCI diagnosis and interventional planning rely on magnetic resonance imaging (MRI), which is not always available or feasible for severely injured patients. Detection of disease-specific biomarkers in biofluids via liquid biopsy may provide a more accessible and objective means of evaluating patients with suspected SCI. Cell-free DNA, which has been used for diagnosing and monitoring oncologic disease, may detect damage to spinal cord neurons via tissue-specific methylation patterns. Other types of biomarkers, including proteins and RNA species, have also been found to reflect neuronal injury and may be included as part of a multi-analyte assay to improve liquid biopsy performance. The feasibility of implementing liquid biopsy into current practices of SCI management is supported by the relative ease of blood sample collection as well as recent advancements in droplet digital polymerase chain reaction technology. In this review, we detail the current landscape of biofluid biomarkers for acute SCI and propose a framework for the incorporation of a putative blood test into the clinical management of SCI. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results