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2 results on '"Taverniti M"'

1. The Italian origins of FAO and Paul Otlet

Author

Guarasci R. and Taverniti M.

Subjects
Paul Otlet, International Institute of Agriculture, Food and Agriculture Organization of the United Nations
Abstract

Nowadays the strategic role of international organizations, which manage and provide information systems and library services in the agricultural domain, is universally recognized. This paper focuses on the origin of the Food and Agriculture Organization of the United Nations (FAO) by presenting a critical edition of the Rapport by Paul Otlet to the marquis Cappelli, président de l'Institut International d'Agricolture (Otlet, 1911) that includes original documents and outlines the first steps taken by the International Institute of Agriculture (IIA), founded in Rome in 1905. The critical edition starts from the original report, preserved in the archival funds of David Lubin, owned by FAO archive and is a collation of IIA's memorandums preserved in the National Library of Rome, and the copious correspondence, between Otlet and Oscar Bolle, the delegate of Belgium, courteously made available by the Mundaneum.

Published
2016

2. Angela R.: a familial Alzheimer's disease case in the days of Auguste D.

Author

Borrello L, Cupidi C, Laganà V, Anfossi M, Conidi ME, Smirne N, Taverniti M, Guarasci R, and Bruni AC

Subjects
Female, History, 19th Century, History, 20th Century, History, 21st Century, Humans, Italy, Male, Alzheimer Disease genetics, Alzheimer Disease history, Family Health, Mutation genetics, Presenilin-1 genetics
Abstract

The rebuilding of the N family, a large Italian kindred affected by early-onset autosomal dominant Alzheimer's disease (AD), provided an important contribution to the discovery of Presenilin 1 (PSEN1), the main gene responsible for familial AD. This pedigree was identified with the help of medical records from the archives of the Psychiatric Hospital of Girifalco, Italy. The clinical record of Angela R., an ancestor of the N family, dating back to 1904, showed a clinical picture of Angela R., consistent with a diagnosis of non-amnestic probable AD, matching the "dysexecutive" phenotype described in her descendants. The a posteriori diagnosis of AD is supported by the evidence of the causative genetic mutation PSEN1-Met146Leu as well as neuropathological AD features in her genealogically proven descendants. The clinical case of Angela R. was recorded at the same time of Alzheimer's description of Auguste D. Its discovery crucially contributed to the genealogical reconstruction of the N family, linking came from different branches, which until then were unrelated, to the same kindred. The archives of the Girifalco Hospital represented a valuable source of medical and historical information and were essential to the research on Italian-American AD families that finally led to the identification of new genes.

Published
2016
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