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BackgroundInternet addiction has become a major global concern and a burden on mental health. However, there is a lack of consensus on its link to mental health outcomes. ObjectiveThe aim of this study was to investigate the associations between internet addiction severity and adverse mental health outcomes. MethodsFirst-year undergraduates enrolled at Sichuan University during September 2015, 2016, 2017, and 2018 were invited to participate in the current study survey, 85.13% (31,659/37,187) of whom fully responded. Young’s 20-item Internet Addiction Test, Patient Health Questionnaire-15, Patient Health Questionnaire-9, Symptom Checklist 90, Six-Item Kessler Psychological Distress Scale, and Suicidal Behaviors Questionnaire-Revised were used to evaluate internet addiction, four psychopathologies (high somatic symptom severity, clinically significant depression, psychoticism, and paranoia), serious mental illness, and lifetime suicidality. ResultsThe prevalence of students with mild, moderate, and severe internet addiction was 37.93% (12,009/31,659), 6.33% (2003/31,659), and 0.20% (63/31,659), respectively. The prevalence rates of high somatic symptom severity, clinically significant depression, psychoticism, paranoid ideation, and serious mental illness were 6.54% (2072/31,659), 4.09% (1294/31,659), 0.51% (160/31,659), 0.52% (165/31,659), and 1.88% (594/31,659), respectively, and the lifetime prevalence rates of suicidal ideation, suicidal plan, and suicidal attempt were 36.31% (11,495/31,659), 5.13% (1624/31,659), and 1.00% (315/31,659), respectively. The prevalence rates and odds ratios (ORs) of the four psychopathologies and their comorbidities, screened serious mental illness, and suicidalities in the group without internet addiction were much lower than the average levels of the surveyed population. Most of these metrics in the group with mild internet addiction were similar to or slightly higher than the average rates; however, these rates sharply increased in the moderate and severe internet addiction groups. Among the four psychopathologies, clinically significant depression was most strongly associated with internet addiction after adjusting for the confounding effects of demographics and other psychopathologies, and its prevalence increased from 1.01% (178/17,584) in the students with no addiction to 4.85% (582/12,009), 24.81% (497/2,003), and 58.73% (37/63) in the students with mild, moderate, and severe internet addiction, respectively. The proportions of those with any of the four psychopathologies increased from 4.05% (713/17,584) to 11.72% (1408/12,009), 36.89% (739/2003), and 68.25% (43/63); those with lifetime suicidal ideation increased from 24.92% (4382/17,584) to 47.56% (5711/12,009), 67.70% (1356/2003), and 73.02% (46/63); those with a suicidal plan increased from 2.59% (456/17,584) to 6.77% (813/12,009), 16.72% (335/2003), and 31.75% (20/63); and those with a suicidal attempt increased from 0.50% (88/17,584) to 1.23% (148/12,009), 3.54% (71/2003), and 12.70% (8/63), respectively. ConclusionsModerate and severe internet addiction were strongly associated with a broad group of adverse mental health outcomes, including somatic symptoms that are the core features of many medical illnesses, although clinically significant depression showed the strongest association. This finding supports the illness validity of moderate and severe internet addiction in contrast to mild internet addiction. These results are important for informing health policymakers and service suppliers from the perspective of resolving the overall human health burden in the current era of “Internet Plus” and artificial intelligence.

AbstractDamqiong Co Lake (DCL) is a high-altitude (4,450 m) soda lake with high salinity (122.45 ± 6.20 g/L) and carbonate concentrations ((10 ± 0.21 g/L of CO32- and 8.77 ± 0.07 g/L of HCO3-) in the Qinghai-Tibet Plateau (QTP). High-throughput sequencing of 16S rRNA genes was used to examine bacterial and archaeal community compositions in the DCL. The result showed that bacterial diversity (Shannon index values of 4.18 ± 0.42) in DCL were significantly higher (P = 0.012) than Archaeal (2.27 ± 1.01). Bacterial communities comprised by 25 phyla, 40 classes, and 205 genera. The dominant bacterial phyla were the Firmicutes (11.23%–70.05%), Proteobacteria (15.47%–45.27%), Bacteroidetes (9.87%–27.88%) and Actinobacteria (0.98%–11.55%). The dominant bacterial genera were Gracilimonas (1.25%–18.95%), Halomonas (3.99%–15.02%), Nitriliruptor (0.76%–11.30%), Bradymonas (0.08%–6.66%), and Brumimicrobium (0.04%–6.47%). Archaeal communities comprised by 5 phyla, 4 classes, and 26 genera. The dominant archaeal phyla were Euryarchaeota (3.69%–97.12%) and Woesearchaeota (2.85%–92.26%), while the dominant genera were Methanomassiliicoccus (0.36%–76.88%), Woesearchaeota AR16 (2.18%–48.61%), Methanolobus (0.32%–19.87%), and Woesearchaeota AR15 (0.27%–18.20%). Correlation heatmap indicated that the diversity in DCL was highly correlated with pH, CO32-, Cl-, Na+, Mg2+, and temperature (P < 0.001). The unique dominant genera of Bacteria (Bradymonas) and Archaea (Methanomassiliicoccus) in DCL suggests that valuable microbial resources may exist in high-altitude soda lakes like the DCL. [ABSTRACT FROM AUTHOR]

To reduce the crushing rate and improve the yield of rice during the milling process, it is significant from a fundamental standpoint to understand the mechanical behaviors of rice under external loads. In this paper, the mechanical properties and fracture morphologies of rice with various moisture contents have been analyzed in detail by experiments and the finite‐element (FE) method. In FE simulations, two‐dimensional (2D) and three‐dimensional (3D) composite models have been established with the cohesive zone model characterizing the interface strength. The results show that the moisture content determines the endosperm cell wall interface strength, and a linear relationship between the interface strength and moisture content has been obtained. In particular, three fracture patterns of brown rice are observed by the competition between the interface strength of starch granule and endosperm cell wall interface strength. Good agreements between FE predictions and experimental results indicate that the combination of the 2D and 3D composite models with the cohesive zone model can provide accurate predictions of the fracture behaviors of brown rice. This investigation should be of great help for understanding the moisture content‐dependent compression and impact behaviors of rice. Practical applications: Brown rice can be obtained by removing the husk through a hulling machine. During these processes, external loads, such as compression and impact, will damage the microstructure of brown rice, which results in a loss rate as high as 25%. Understanding the mechanical properties of brown rice with different moisture contents will be of great help in designing the equipment used in rice processing operations and extending the yield of polished rice. [ABSTRACT FROM AUTHOR]

With the continuous development of rural revitalization and urbanization in China, the sustainable transformation of traditional rural architecture has become increasingly important. This study takes the Thangka exhibition hall in rural Malkang, Sichuan Province, as the research object and proposes a Thangka exhibition hall architectural design centered around solar heating and aiming for near-zero energy consumption. The research method involves establishing a solar energy system model on the roof of the exhibition hall and utilizing solar angle and area calculation formulas along with simulation software to calculate the optimal installation angle and area of solar panels, with the aim of achieving indoor temperatures that meet Thangka protection requirements while achieving zero-energy heating. Preliminary results indicate that this solar-centric near-zero energy architectural design can effectively promote the increase in indoor temperature through solar thermal conversion. Additionally, through calculation and simulation, the optimal installation angle for the solar panels achieving zero-energy heating is determined to be 24.25 with an azimuth angle of −1.2. The optimum installation area for solar panels is 8.2 square meters in the showroom and 2.7 square meters in the storeroom. Among these, the solar panel area for the Thangka exhibition hall constitutes 4.12% of the total area and is required for maintaining Thangka protection temperature requirements throughout the year, while the solar panel area for the storage room constitutes 1.88% and is also needed for the same purpose. Studying the optimal installation angle and area of solar panels can transform the exhibition hall into a near-zero-energy building, meeting the temperature requirements for Thangka preservation and human thermal comfort, while also achieving optimal economic benefits. This provides guidance and a reference for promoting near-zero-energy buildings in rural areas. [ABSTRACT FROM AUTHOR]

Chronic wound healing remains challenging due to the oxidative microenvironment. Prussian blue (PB) nanoparticles exhibiting multiple antioxidant enzyme-like activities have attracted widespread attention, while their antioxidant efficacy remains unsatisfied. Herein, ultrasmall calcium-enriched Prussian blue nanoparticles (CaPB NPs) are simply constructed with high yields for the wound repair application. Owing to the ultrasmall size and synergistic effect of the generated dual active sites, the CaPB NPs exhibit prominent antioxidase-like activities, protecting cells from oxidative stress-induced damage. In addition to the effect of Ca on regulating keratinocyte and fibroblast growth, it has been demonstrated that the administration of CaPB NPs obviously promoted wound closure as well as collagen deposition and neovascularization in the full-thickness wound defect model in mice. Importantly, the CaPB NP treatment can effectively up-regulate the expression levels of anti-inflammatory cytokines and vascular endothelial growth factors to remodel the wound microenvironment, thereby accelerating the wound healing process. Overall, this work reveals that metal atom substitution is an effective strategy to construct ultrasmall and high-catalytic-performance PB-based nanozymes and further potentiate their effectiveness for chronic wound management. [ABSTRACT FROM AUTHOR]