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952 results on '"Tang, W.H. Wilson"'

2. The Gut Microbial Metabolite Trimethylamine N-oxide, Incident CKD, and Kidney Function Decline

Author

Wang, Meng, Tang, W.H. Wilson, Li, Xinmin S., de Oliveira Otto, Marcia C., Lee, Yujin, Lemaitre, Rozenn N., Fretts, Amanda, Nemet, Ina, Sotoodehnia, Nona, Sitlani, Colleen M., Budoff, Matthew, DiDonato, Joseph A., Wang, Zeneng, Bansal, Nisha, Shlipak, Michael G., Psaty, Bruce M., Siscovick, David S., Sarnak, Mark J., Mozaffarian, Dariush, and Hazen, Stanley L.

Published
2024
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20. 2023 HRS/APHRS/LAHRS guideline on cardiac physiologic pacing for the avoidance and mitigation of heart failure

Author

Chung, Mina K., Patton, Kristen K., Lau, Chu-Pak, Dal Forno, Alexander R.J., Al-Khatib, Sana M., Arora, Vanita, Birgersdotter-Green, Ulrika Maria, Cha, Yong-Mei, Chung, Eugene H., Cronin, Edmond M., Curtis, Anne B., Cygankiewicz, Iwona, Dandamudi, Gopi, Dubin, Anne M., Ensch, Douglas P., Glotzer, Taya V., Gold, Michael R., Goldberger, Zachary D., Gopinathannair, Rakesh, Gorodeski, Eiran Z., Gutierrez, Alejandra, Guzman, Juan C., Huang, Weijian, Imrey, Peter B., Indik, Julia H., Karim, Saima, Karpawich, Peter P., Khaykin, Yaariv, Kiehl, Erich L., Kron, Jordana, Kutyifa, Valentina, Link, Mark S., Marine, Joseph E., Mullens, Wilfried, Park, Seung-Jung, Parkash, Ratika, Patete, Manuel F., Pathak, Rajeev Kumar, Perona, Carlos A., Rickard, John, Schoenfeld, Mark H., Seow, Swee-Chong, Shen, Win-Kuang, Shoda, Morio, Singh, Jagmeet P., Slotwiner, David J., Sridhar, Arun Raghav M., Srivatsa, Uma N., Stecker, Eric C., Tanawuttiwat, Tanyanan, Tang, W.H. Wilson, Tapias, Carlos Andres, Tracy, Cynthia M., Upadhyay, Gaurav A., Varma, Niraj, Vernooy, Kevin, Vijayaraman, Pugazhendhi, Worsnick, Sarah Ann, Zareba, Wojciech, and Zeitler, Emily P.

Published
2023
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23. Classification and Predictors of Right Ventricular Functional Recovery in Pulmonary Arterial Hypertension

Author

Rischard, Franz P., Bernardo, Roberto J., Vanderpool, Rebecca R., Kwon, Deborah H., Acharya, Tushar, Park, Margaret M., Katrynuik, Austin, Insel, Michael, Kubba, Saad, Badagliacca, Roberto, Larive, A. Brett, Naeije, Robert, Garcia, Joe G.N., Beck, Gerald J., Erzurum, Serpil C., Frantz, Robert P., Hassoun, Paul M., Hemnes, Anna R., Hill, Nicholas S., Horn, Evelyn M., Leopold, Jane A., Rosenzweig, Erika B., Tang, W.H. Wilson, and Wilcox, Jennifer D.

Published
2023
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26. Microbially Produced Imidazole Propionate Is Associated With Heart Failure and Mortality

Author

Alves, Renato, Amouyal, Chloe, Andersson Galijatovic, Ehm Astrid, Andreelli, Fabrizio, Barthelemy, Olivier, Bastard, Jean-Philippe, Batisse, Jean-Paul, Berland, Magalie, Bittar, Randa, Blüher, Matthias, Bork, Peer, Bourron, Olivier, Camus, Mickael, Cassuto, Dominique, Ciangura, Cecile, Coelho, Luis Pedro, Collet, Jean-Philippe, Dumas, Marc-Emmanuel, Ehrlich, S. Dusko, Engelbrechtsen, Line, Fezeu, Leopold, Forslund, Sofia, Fromentin, Sebastien, Galan, Pilar, Giral, Philippe, Gøtze, Jens Peter, Hansen, Torben, Hansen, Tue H., Hartemann, Agnes, Hartmann, Bolette, Hercberg, Serge, Holmes, Bridget, Holst, Jens Juul, Hornbak, Malene, Hoyles, Lesley, Hulot, Jean-Sebastien, Jaqueminet, Sophie, Kerneis, Mathieu, Khemis, Jean, Kozlowski, Ruby, Pedersen, Helle Krogh, Kuhn, Michael, Mannerås-Holm, Louise, Marko, Lajos, Martinez-Gili Robin Massey, Laura, Maziers, Nicolas, Medina-Stamminger, Jonathan, Moitinho-Silva, Lucas, Montalescot, Gilles, Moutel, Sandrine, Neves, Ana Luisa, Olanipekun, Michael, Oppert, Jean-Michel, Poitou, Christine, Pousset, Francoise, Pouzoulet, Laurence, Rouault, Christine, Silvain, Johanne, Vestergaard, Henrik, Molinaro, Antonio, Nemet, Ina, Bel Lassen, Pierre, Chakaroun, Rima, Nielsen, Trine, Aron-Wisnewsky, Judith, Bergh, Per-Olof, Li, Lin, Henricsson, Marcus, Køber, Lars, Isnard, Richard, Helft, Gerard, Stumvoll, Michael, Pedersen, Oluf, Smith, J. Gustav, Tang, W.H. Wilson, Clément, Karine, Hazen, Stanley L., and Bäckhed, Fredrik

Published
2023
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30. Rationale and design of the Aldose Reductase Inhibition for Stabilization of Exercise Capacity in Heart Failure Trial (ARISE-HF) in patients with high-risk diabetic cardiomyopathy

Author

Januzzi, James L., Jr, Butler, Javed, Del Prato, Stefano, Ezekowitz, Justin A., Ibrahim, Nasrien E., Lam, Carolyn S.P., Lewis, Gregory D., Marwick, Thomas H., Rosenstock, Julio, Tang, W.H. Wilson, Zannad, Faiez, Lawson, Francesca, Perfetti, Riccardo, and Urbinati, Alessia

Published
2023
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38. Clinical Characteristics and Transplant-Free Survival Across the Spectrum of Pulmonary Vascular Disease

Author

Hemnes, Anna R., Leopold, Jane A., Radeva, Milena K., Beck, Gerald J., Abidov, Aiden, Aldred, Micheala A., Barnard, John, Rosenzweig, Erika B., Borlaug, Barry A., Chung, Wendy K., Comhair, Suzy A.A., Desai, Ankit A., Dubrock, Hilary M., Erzurum, Serpil C., Finet, J. Emanuel, Frantz, Robert P., Garcia, Joe G.N., Geraci, Mark W., Gray, Michael P., Grunig, Gabriele, Hassoun, Paul M., Highland, Kristin B., Hill, Nicholas S., Hu, Bo, Kwon, Deborah H., Jacob, Miriam S., Jellis, Christine L., Larive, A. Brett, Lempel, Jason K., Maron, Bradley A., Mathai, Stephen C., McCarthy, Kevin, Mehra, Reena, Nawabit, Rawan, Newman, John H., Olman, Mitchell A., Park, Margaret M., Ramos, Jose A., Renapurkar, Rahul D., Rischard, Franz P., Sherer, Susan G., Tang, W.H. Wilson, Thomas, James D., Vanderpool, Rebecca R., Waxman, Aaron B., Wilcox, Jennifer D., Yuan, Jason X.-J., and Horn, Evelyn M.

Published
2022
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42. Comprehensive Clinical and Genetic Analyses of Circulating Bile Acids and Their Associations With Diabetes and Its Indices.

Author

Choucair, Ibrahim, Mallela, Deepthi P., Hilser, James R., Hartiala, Jaana A., Nemet, Ina, Gogonea, Valentin, Li, Lin, Lusis, Aldons J., Fischbach, Michael A., Tang, W.H. Wilson, Allayee, Hooman, and Hazen, Stanley L.

Subjects
LIQUID chromatography-mass spectrometry, DEOXYCHOLIC acid, BILE acids, DIABETES, HIGH performance liquid chromatography, GENOME-wide association studies
Abstract

Bile acids (BAs) are cholesterol-derived compounds that regulate glucose, lipid, and energy metabolism. Despite their significance in glucose homeostasis, the association between specific BA molecular species and their synthetic pathways with diabetes is unclear. Here, we used a recently validated, stable-isotope dilution, high-performance liquid chromatography with tandem mass spectrometry method to quantify a panel of BAs in fasting plasma from 2,145 study participants and explored structural and genetic determinants of BAs linked to diabetes, insulin resistance, and obesity. Multiple 12α-hydroxylated BAs were associated with diabetes (adjusted odds ratio [aOR] range, 1.3–1.9; P < 0.05 for all) and insulin resistance (aOR range, 1.3–2.2; P < 0.05 for all). Conversely, multiple 6α-hydroxylated BAs and isolithocholic acid (iso-LCA) were inversely associated with diabetes and obesity (aOR range, 0.3–0.9; P < 0.05 for all). Genome-wide association studies revealed multiple genome-wide significant loci linked with 9 of the 14 diabetes-associated BAs, including a locus for iso-LCA (rs11866815). Mendelian randomization analyses showed genetically elevated deoxycholic acid levels were causally associated with higher BMI, and iso-LCA levels were causally associated with reduced BMI and diabetes risk. In conclusion, comprehensive, large-scale, quantitative mass spectrometry and genetics analyses show circulating levels of multiple structurally specific BAs, especially DCA and iso-LCA, are clinically associated with and genetically linked to obesity and diabetes. Article Highlights: The association between specific circulating bile acid (BA) molecular species and diabetes in humans is not extensively studied. In the present study, we found that multiple 12α-hydroxylated BAs are positively associated with diabetes and insulin resistance, whereas multiple 6α-hydroxylated BAs are inversely associated with diabetes and obesity. Mendelian randomization analyses show isolithocholic acid levels are causally associated with reduced risk for diabetes and obesity, and deoxycholic acid levels are causally associated with obesity risk. The findings of this study provide new avenues for investigating the role of BAs in metabolic diseases and may have substantial therapeutic implications. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Pulmonary hypertension across the spectrum of left heart and lung disease.

Author

Borlaug, Barry A., Larive, Brett, Frantz, Robert P., Hassoun, Paul, Hemnes, Anna, Horn, Evelyn, Leopold, Jane, Rischard, Franz, Berman‐Rosenzweig, Erika, Beck, Gerald, Erzurum, Serpil, Farha, Samar, Finet, J. Emanuel, Highland, Kristin B., Jacob, Miriam, Jellis, Christine, Mehra, Reena, Renapurkar, Rahul, Singh, Harsimran, and Tang, W.H. Wilson

Subjects
BRAIN natriuretic factor, LUNG diseases, HEART diseases, PULMONARY hypertension, CORONARY disease
Abstract

Aims: Patients with pulmonary hypertension (PH) are grouped based upon clinical and haemodynamic characteristics. Groups 2 (G2, left heart disease [LHD]) and 3 (G3, lung disease or hypoxaemia) are most common. Many patients display overlapping characteristics of heart and lung disease (G2–3), but this group is not well‐characterized. Methods and results: Patients with PH enrolled in the prospective, NHLBI‐sponsored PVDOMICS network underwent intensive clinical, biomarker, imaging, gas exchange and exercise phenotyping. Patients with pure G2, pure G3, or overlapping G2–3 PH were compared across multiple phenotypic domains. Of all patients with predominant G2 (n = 136), 66 (49%) were deemed to have secondary lung disease/hypoxaemia contributors (G2/3), and of all patients categorized as predominant G3 (n = 172), 41 (24%) were judged to have a component of secondary LHD (G3/2), such that 107 had G2–3 (combined G2/3 and G3/2). As compared with G3, patients with G2 and G2–3 were more obese and had greater prevalence of hypertension, atrial fibrillation, and coronary disease. Patients with G2 and G2–3 were more anaemic, with poorer kidney function, more cardiac dysfunction, and higher N‐terminal pro‐B‐type natriuretic peptide than G3. Lung diffusion was more impaired in G3 and G2–3, but commonly abnormal even in G2. Exercise capacity was severely and similarly impaired across all groups, with no differences in 6‐min walk distance or peak oxygen consumption, and pulmonary vasoreactivity to nitric oxide did not differ. In a multivariable Cox regression model, patients with G2 had lower risk of death or transplant compared with G3 (hazard ratio [HR] 0.51, 95% confidence interval [CI] 0.30–0.86), and patients with G2–3 also displayed lower risk compared with G3 (HR 0.57, 95% CI 0.38–0.86). Conclusions: Overlap is common in patients with a pulmonary or cardiac basis for PH. While lung structure/function is clearly more impaired in G3 and G2–3 than G2, pulmonary abnormalities are common in G2, even when clinically judged as isolated LHD. Further study is required to identify optimal systematic evaluations to guide therapeutic innovation for PH associated with combined heart and lung disease. Clinical Trial Registration: ClinicalTrials.gov NCT02980887. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Decongestion With Acetazolamide in Acute Decompensated Heart Failure Across the Spectrum of Left Ventricular Ejection Fraction: A Prespecified Analysis From the ADVOR Trial

Author

Martens, Pieter, Dauw, Jeroen, Verbrugge, Frederik H., Nijst, Petra, Meekers, Evelyne, Augusto, Silvio Nunes, Jr, Ter Maaten, Jozine M., Damman, Kevin, Mebazaa, Alexandre, Filippatos, Gerasimos, Ruschitzka, Frank, Tang, W.H. Wilson, Dupont, Matthias, and Mullens, Wilfried

Published
2023
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