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4. Favorable impact of azithromycin on patients in the intensive care unit with coronavirus disease 2019: Insights from the first wave using a Japanese database

Author

Tokito, Takatomo, Kido, Takashi, Sato, Shuntaro, Tashiro, Masato, Miyashita, Ritsuko, Ozasa, Mutsumi, Okuno, Daisuke, Yura, Hirokazu, Takemoto, Shinnosuke, Takazono, Takahiro, Ishimoto, Hiroshi, Sakamoto, Noriho, Tanaka, Takeshi, Obase, Yasushi, Ishimatsu, Yuji, Nishino, Tomoya, Fushimi, Kiyohide, Izumikawa, Koichi, and Mukae, Hiroshi

Published
2024
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5. Global guideline for the diagnosis and management of cryptococcosis: an initiative of the ECMM and ISHAM in cooperation with the ASM

Author

Chang, Christina C, Harrison, Thomas S, Bicanic, Tihana A, Chayakulkeeree, Methee, Sorrell, Tania C, Warris, Adilia, Hagen, Ferry, Spec, Andrej, Oladele, Rita, Govender, Nelesh P, Chen, Sharon C, Mody, Christopher H, Groll, Andreas H, Chen, Yee-Chun, Lionakis, Michail S, Alanio, Alexandre, Castañeda, Elizabeth, Lizarazo, Jairo, Vidal, José E, Takazono, Takahiro, Hoenigl, Martin, Alffenaar, Jan-Willem, Gangneux, Jean-Pierre, Soman, Rajeev, Zhu, Li-Ping, Bonifaz, Alexandro, Jarvis, Joseph N, Day, Jeremy N, Klimko, Nikolai, Salmanton-García, Jon, Jouvion, Grégory, Meya, David B, Lawrence, David, Rahn, Sebastian, Bongomin, Felix, McMullan, Brendan J, Sprute, Rosanne, Nyazika, Tinashe K, Beardsley, Justin, Carlesse, Fabianne, Heath, Christopher H, Ayanlowo, Olusola O, Mashedi, Olga M, Queiroz-Telles Filho, Flavio, Hosseinipour, Mina C, Patel, Atul K, Temfack, Elvis, Singh, Nina, Cornely, Oliver A, Boulware, David R, Lortholary, Olivier, Pappas, Peter G, and Perfect, John R

Published
2024
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7. Pulmonary function and chest CT abnormalities 3 months after discharge from COVID-19, 2020–2021: A nation-wide multicenter prospective cohort study from the Japanese respiratory society

Author

Kamata, Hirofumi, Takamatsu, Kazufumi, Fukunaga, Koichi, Chubachi, Shotaro, Nakagawara, Kensuke, Namkoong, Ho, Terai, Hideki, Tanaka, Katsushi, Sato, Susumu, Hagiwara, Eri, Takei, Reoto, Kondoh, Yasuhiro, Takazono, Takahiro, Hashimoto, Midori, Tasaka, Sadatomo, Ohrui, Takashi, Tanino, Yoshinori, Mineshita, Masamichi, Komase, Yuko, Miyazaki, Kazuhito, Nishikawa, Masanori, Ando, Akira, Kita, Hideo, Ichihara, Eiki, Ohshimo, Shinichiro, Murata, Yoriyuki, Ishida, Masayuki, Kobayashi, Seiichi, Uchida, Takahiro, Tateno, Hiroki, Ikari, Jun, Terashima, Takeshi, Kozu, Yutaka, Tateishi, Tomoya, Shinkai, Masaharu, Sagara, Hironori, To, Yasuo, Ito, Yoko, Yamamoto, Masaki, Yamamoto, Yoshihiro, Kita, Toshiyuki, Ito, Yutaka, Tomii, Keisuke, Fujita, Yukio, Funaki, Yoshihiro, Yatera, Kazuhiro, Yamasue, Mari, Komiya, Kosaku, Kozawa, Satoko, Manabe, Hideaki, Hozumi, Hironao, Horiguchi, Tomoya, Kitajima, Takamasa, Nakano, Yasushi, Nagaoka, Tetsutaro, Hojo, Masayuki, Ebihara, Akinori, Kobayashi, Masayoshi, Takayama, Koji, Jinta, Torahiko, Sawai, Toyomitsu, Fukuda, Yuichi, Kaneko, Takeshi, Chin, Kazuo, Ogura, Takashi, Mukae, Hiroshi, Ishii, Makoto, and Yokoyama, Akihito

Published
2024
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8. Efficacy and safety of lascufloxacin for nursing- and healthcare-associated pneumonia: A single-arm, open-label clinical trial

Author

Takazono, Takahiro, Hosogaya, Naoki, Fukushima, Koki, Morio, Ryosuke, Irifune, Satoshi, Miyamura, Takuto, Harada, Yosuke, Nagayoshi, Yosuke, Kondo, Akira, Mihara, Tomo, Fukuda, Yuichi, Sasaki, Eisuke, Sawai, Toyomitsu, Imamura, Yoshifumi, Morikawa, Toru, Futsuki, Yoji, Inoue, Yuichi, Fukushima, Kiyoyasu, Suyama, Naofumi, Tanaka, Hikaru, Hanaka, Tetsuya, Shimabukuro, Ikuko, Hata, Ryosuke, Ota, Kenji, Morimoto, Shimpei, Nakada, Nana, Ito, Yuya, Yoshida, Masataka, Takeda, Kazuaki, Ide, Shotaro, Iwanaga, Naoki, Nemoto, Kazuki, Funada, Midori, Izumikawa, Koichi, Yatera, Kazuhiro, Yanagihara, Katsunori, and Mukae, Hiroshi

Published
2024
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10. A high α1-antitrypsin/interleukin-10 ratio predicts bacterial pneumonia in adults with community-acquired pneumonia: a prospective cohort study

Author

Miyazaki, Taiga, Fukushima, Kiyoyasu, Hashiguchi, Kohji, Ide, Shotaro, Kobayashi, Tsutomu, Sawai, Toyomitsu, Yatera, Kazuhiro, Kohno, Yoshihisa, Fukuda, Yuichi, Futsuki, Yoji, Matsubara, Yuichi, Koga, Hironobu, Mihara, Tomo, Sasaki, Eisuke, Ashizawa, Nobuyuki, Hirayama, Tatsuro, Takazono, Takahiro, Yamamoto, Kazuko, Imamura, Yoshifumi, Kaku, Norihito, Kosai, Kosuke, Morinaga, Yoshitomo, Yanagihara, Katsunori, and Mukae, Hiroshi

Published
2023
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13. Risk factor of non-tuberculous Mycobacterium infection in patients with rheumatoid arthritis and other autoimmune diseases receiving biologic agents: A multicenter retrospective study

Author

Ashizawa, Hiroki, Takazono, Takahiro, Kawashiri, Shin-ya, Nakada, Nana, Ito, Yuya, Ashizawa, Nobuyuki, Hirayama, Tatsuro, Yoshida, Masataka, Takeda, Kazuaki, Iwanaga, Naoki, Takemoto, Shinnosuke, Ide, Shotaro, Mihara, Tomo, Tomari, Shinya, Sakamoto, Noriho, Obase, Yasushi, Izumikawa, Koichi, Yanagihara, Katsunori, Kawakami, Atsushi, and Mukae, Hiroshi

Published
2024
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14. Pre-clinical and clinical evaluation of a surface plasmon field-enhanced fluorescence spectroscopy (SPFS) antigen test for detecting SARS-CoV-2

Author

Ashizawa, Nobuyuki, Takazono, Takahiro, Ota, Kenji, Ito, Yuya, Hirayama, Tatsuro, Takeda, Kazuaki, Ide, Shotaro, Iwanaga, Naoki, Fujita, Ayumi, Tashiro, Masato, Hosogaya, Naoki, Akamatsu, Norihiko, Kosai, Kosuke, Tanaka, Takeshi, Kobayashi, Hironori, Yamauchi, Ryosuke, Segawa, Chie, Koizumi, Hikaru, Taka, Natsumi, Hishigaki, Haretsugu, Yamamoto, Kazuko, Izumikawa, Koichi, Yanagihara, Katsunori, and Mukae, Hiroshi

Published
2024
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17. Efficacy and safety of isavuconazole against deep-seated mycoses: A phase 3, randomized, open-label study in Japan

Author

Kohno, Shigeru, Izumikawa, Koichi, Takazono, Takahiro, Miyazaki, Taiga, Yoshida, Minoru, Kamei, Katsuhiko, Ogawa, Kenji, Taniguchi, Shuichi, Akashi, Koichi, Tateda, Kazuhiro, Mukae, Hiroshi, Miyazaki, Yoshitsugu, Okada, Fumito, Kanda, Yoshinobu, Kakeya, Hiroshi, Suzuki, Junko, Kimura, Shun-ichi, Kishida, Mitsukazu, Matsuda, Miyuki, and Niki, Yoshihito

Published
2023
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18. Clinical manifestations of hospitalized influenza patients without risk factors: A prospective multicenter cohort study in Japan via internet surveillance

Author

Ishida, Tadashi, Seki, Masafumi, Oishi, Kazunori, Tateda, Kazuhiro, Fujita, Jiro, Kadota, Jun-ichi, Kawana, Akihiko, Izumikawa, Koichi, Kikuchi, Toshiaki, Ohmagari, Norio, Yamada, Mitsuhiro, Maruyama, Takaya, Takazono, Takahiro, Miki, Makoto, Miyazaki, Yoshitsugu, Yamazaki, Yoshitaka, Kakeya, Hiroshi, Ogawa, Kenji, Nagai, Hideaki, and Watanabe, Akira

Published
2022
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20. Neglected Pulmonary Infection Caused by Exophiala dermatitidis Misidentified as Rhodotorula spp.

Author

Setoguchi, Daichi, Iwanaga, Naoki, Ito, Yuya, Hirayama, Tatsuro, Yoshida, Masataka, Takeda, Kazuaki, Ide, Shotaro, Takemoto, Shinnosuke, Tashiro, Masato, Hosogaya, Naoki, Takazono, Takahiro, Kosai, Kosuke, Ishimoto, Hiroshi, Sakamoto, Noriho, Obase, Yasushi, Nishino, Tomoya, Izumikawa, Koichi, Yanagihara, Katsunori, and Mukae, Hiroshi

Subjects
PULMONARY aspergillosis, LUNG infections, NOCARDIOSIS, STEROID drugs, RHODOTORULA
Abstract

Exophiala dermatitidis is an emerging black fungus that causes pulmonary infections that may be underestimated by conventional culture methods. We encountered one case that initially appeared to be yeast and was misidentified as Rhodotorula spp. using a commercial identification kit. Thus, genetic identification and clinical background investigations were conducted on 46 strains of Rhodotorula spp. The sequences of the internal transcribed spacer and large‐subunit RNA genes (D1/D2 regions) of 43 isolates, excluding two environmental isolates and one difficult‐to‐culture isolate, were determined and genetically identified. Notably, 22 isolates were identified as E. dermatitidis and misidentified as Rhodotorula spp. using the conventional method. Based on the exclusion criteria, the clinical information of 11 patients was retrospectively reviewed. Five cases (definite) had definite exacerbation of pulmonary infections due to E. dermatitidis, and six cases (possible) had undeniable infections. Of the 11 cases of pulmonary infection suggested to be caused by E. dermatitidis, comorbidities included two cases of chronic pulmonary aspergillosis (CPA), three cases of pulmonary non‐tuberculous mycobacterial (NTM) infection and one case of pulmonary nocardiosis, suggesting a trend towards simultaneous detection of chronic pulmonary infections. Steroid and immunosuppressive drug use was observed in five cases, and β‐D‐glucan elevation was observed in three of five definite cases of pulmonary infections due to E. dermatitidis. The possibility of E. dermatitidis infection should be considered when Rhodotorula spp. are isolated from cultures of airway‐derived specimens, and, in addition to CPA and NTM, identification of E. dermatitidis may be important in chronic pulmonary infections. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Comparison of the Effectiveness of Baloxavir and Oseltamivir in Outpatients With Influenza B.

Author

Takazono, Takahiro, Ito, Genta, Hosogaya, Naoki, Iwanaga, Naoki, Komeda, Takuji, Kobayashi, Masayuki, Kitanishi, Yoshitake, Ogura, Eriko, and Mukae, Hiroshi

Subjects
*DATABASES, *HEART failure, *HEALTH insurance, *INFLUENZA, *DRUG utilization
Abstract

This retrospective cohort study analyzed data from a Japanese health insurance database to assess the effectiveness of baloxavir (n = 4822) for preventing severe events compared with oseltamivir (n = 10,523) in patients with influenza B. The primary endpoint was hospitalization incidence (Days 2–14). The secondary endpoints included intravenous antibacterial drug use, pneumonia hospitalization, heart failure hospitalization, inhalational oxygen requirement, and use of other anti‐influenza drugs. The hospitalization incidence was significantly lower with baloxavir (0.15% vs. 0.37%; risk ratio: 2.48, 95% confidence interval: 1.13–5.43). Pneumonia and additional anti‐influenza therapy were also less frequent with baloxavir, thus supporting its use. Trial Registration: UMIN Clinical Trials Registry Study ID: UMIN000051382 [ABSTRACT FROM AUTHOR]

Published
2024
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22. Clarithromycin Modulates Neutrophilic Inflammation Induced by Prevotella intermedia in Human Airway Epithelial Cells.

Author

Iwanaga, Naoki, Ota, Ayaka, Ashizawa, Hiroki, Ito, Yuya, Hirayama, Tatsuro, Yoshida, Masataka, Takeda, Kazuaki, Ide, Shotaro, Tashiro, Masato, Hosogaya, Naoki, Sakamoto, Noriho, Takazono, Takahiro, Kosai, Kosuke, Naito, Mariko, Tanaka, Yoshimasa, Yatera, Kazuhiro, Izumikawa, Koichi, Yanagihara, Katsunori, and Mukae, Hiroshi

Subjects
EXTRACELLULAR signal-regulated kinases, MITOGEN-activated protein kinases, PROTEIN kinase inhibitors, GENETIC transcription, EPITHELIAL cells
Abstract

Objectives: In the present study, we aimed to clarify the mechanisms by which periodontal pathogens, particularly Prevotella intermedia, induce severe neutrophilic inflammation. In addition, we aimed to test the efficacy of macrolides, which has not been resolved in the neutrophilic inflammation induced by P. intermedia. Methods: NCl-H292 human airway epithelial cells were pre-incubated with clarithromycin for 2 h before incubation with P. intermedia supernatants. Then, C-X-C motif chemokine ligand 8 (CXCL8) transcription and interleukin (IL)-8 production were measured. To elucidate the signaling pathway, mitogen-activated protein kinase inhibitors were added to the cell culture, and the cells were subjected to Western blotting. Results:P. intermedia supernatants promoted CXCL8 transcription and IL-8 production, and the reactions were significantly suppressed by clarithromycin pretreatment. Only trametinib, the selective mitogen-activated extracellular signal-regulated kinase inhibitor, downregulated CXCL8 transcription and IL-8 production. Furthermore, Western blotting revealed that stimulation with P. intermedia supernatants specifically induces extracellular signal-regulated kinases (ERK) 1/2 phosphorylation, which is suppressed by clarithromycin pretreatment. Notably, the interference analysis revealed that ERK3 might be dispensable for IL-8 production under the stimulation of P. intermedia supernatants. Conclusions: Our results provide new insight into the mechanism underlying P. intermedia-induced production of IL-8 from human airway epithelial cells. Furthermore, macrolides might have therapeutic potential in regulating periodontal pathogen-induced neutrophilic inflammation in the lungs. [ABSTRACT FROM AUTHOR]

Published
2024
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24. HLA-B54 is an independent risk factor for pneumonia in Japanese patients with interstitial lung disease: A multicenter retrospective cohort study

Author

Sakamoto, Noriho, Ishimoto, Hiroshi, Tahara, Masahiro, Kido, Takashi, Hara, Atsuko, Miyamura, Takuto, Okuno, Daisuke, Tokito, Takatomo, Yoshioka, Sumako, Morimoto, Shimpei, Takazono, Takahiro, Yamamoto, Kazuko, Yamaguchi, Hiroyuki, Obase, Yasushi, Ishimatsu, Yuji, Yatera, Kazuhiro, and Mukae, Hiroshi

Published
2021
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26. Evaluation of four commercial severe acute respiratory coronavirus 2 antibody tests

Author

Ashizawa, Nobuyuki, Takazono, Takahiro, Ohyama, Kaname, Nagasaki, Yoji, Okamoto, Masaki, Hirayama, Tatsuro, Takahashi, Kensuke, Yamanashi, Hirotomo, Tashiro, Masato, Hosogaya, Naoki, Tanaka, Takeshi, Yamamoto, Kazuko, Fukuda, Yuichi, Imamura, Yoshifumi, Kawanami, Toshinori, Miyazaki, Taiga, Sawai, Toyomitsu, Fukushima, Kiyoyasu, Yatera, Kazuhiro, Yanagihara, Katsunori, Izumikawa, Koichi, and Mukae, Hiroshi

Published
2021
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27. Clinical manifestations of adult patients requiring influenza-associated hospitalization: A prospective multicenter cohort study in Japan via internet surveillance

Author

Ishida, Tadashi, Seki, Masafumi, Oishi, Kazunori, Tateda, Kazuhiro, Fujita, Jiro, Kadota, Jun-ichi, Kawana, Akihiko, Izumikawa, Koichi, Kikuchi, Toshiaki, Ohmagari, Norio, Yamada, Mitsuhiro, Maruyama, Takaya, Takazono, Takahiro, Miki, Makoto, Miyazaki, Yoshitsugu, Yamazaki, Yoshitaka, Kakeya, Hiroshi, Ogawa, Kenji, Nagai, Hideaki, and Watanabe, Akira

Published
2021
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28. Unplanned hemodialysis initiation: A retrospective analysis of patient characteristics and prognosis in an emergency hospital.

Author

Kitamura, Mineaki, Yamashita, Hiroshi, Sugiyama, Sayaka, Kuroki, Ryoma, Fukuda, Haruka, Sawase, Atsushi, Tsuchiyama, Ayaka, Takehara, Kosuke, Watanabe, Junichi, Takazono, Takahiro, Imamura, Ryoichi, Mukae, Hiroshi, and Nishino, Tomoya

Subjects
HEMODIALYSIS patients, JAPANESE people, HOSPITAL emergency services, HEMODIALYSIS, PROGNOSIS
Abstract

Introduction: Functional decline occurs during dialysis initiation, particularly in unplanned cases. To prevent unplanned hemodialysis, we aimed to identify associated factors from the first referral to the nephrology department to hemodialysis initiation and assess patient prognosis post‐unplanned hemodialysis initiation. Methods: This retrospective study involved 257 Japanese patients initiating hemodialysis and compared patient characteristics based on whether hemodialysis was planned or unplanned at a single center. Patient outcomes were evaluated in collaboration with maintenance hemodialysis centers. Results: Unplanned hemodialysis initiation correlated with heart failure history (p < 0.05) and infections like pneumonia (p < 0.001). Patients with unplanned hemodialysis initiation had a worse prognosis than those with planned initiation (p < 0.001), and multivariable Cox regression showed it as an independent risk factor for death (p < 0.05). Conclusions: Hygiene and careful attention to heart failure may reduce unplanned hemodialysis and improve patient well‐being and healthcare efficiency. This retrospective analysis highlights crucial considerations for optimizing the initiation of hemodialysis. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Development of a score model to predict long‐term prognosis after community‐onset pneumonia in older patients.

Author

Takazono, Takahiro, Namie, Hotaka, Nagayoshi, Yohsuke, Imamura, Yoshifumi, Ito, Yuya, Sumiyoshi, Makoto, Ashizawa, Nobuyuki, Yoshida, Masataka, Takeda, Kazuaki, Iwanaga, Naoki, Ide, Shotaro, Harada, Yosuke, Hosogaya, Naoki, Takemoto, Shinnosuke, Fukuda, Yuichi, Yamamoto, Kazuko, Miyazaki, Taiga, Sakamoto, Noriho, Obase, Yasushi, and Sawai, Toyomitsu

Subjects
*OLDER patients, *ADVANCE directives (Medical care), *PROGNOSIS, *PNEUMONIA, *MULTIVARIATE analysis
Abstract

Background and Objective: The identification of factors associated with long‐term prognosis after community‐onset pneumonia in elderly patients should be considered when initiating advance care planning (ACP). We aimed to identify these factors and develop a prediction score model. Methods: Patients aged 65 years and older, who were hospitalized for pneumonia at nine collaborating institutions, were included. The prognosis of patients 180 days after the completion of antimicrobial treatment for pneumonia was prospectively collected. Results: The total number of analysable cases was 399, excluding 7 outliers and 42 cases with missing data or unknown prognosis. These cases were randomly divided in an 8:2 ratio for score development and testing. The median age was 82 years, and there were 68 (17%) deaths. A multivariate analysis showed that significant factors were performance status (PS) ≥2 (Odds ratio [OR], 11.78), hypoalbuminemia ≤2.5 g/dL (OR, 5.28) and dementia (OR, 3.15), while age and detection of antimicrobial‐resistant bacteria were not associated with prognosis. A scoring model was then developed with PS ≥2, Alb ≤2.5, and dementia providing scores of 2, 1 and 1 each, respectively, for a total of 4. The area under the curve was 0.8504, and the sensitivity and specificity were 94.6% and 61.7% at the cutoff of 2, respectively. In the test cases, the sensitivity and specificity were 91.7% and 63.1%, respectively, at a cutoff value of 2. Conclusion: Patients meeting this score should be considered near the end of life, and the initiation of ACP practices should be considered. We aimed to identify factors influencing the long‐term prognosis of elderly patients with pneumonia and to develop a prediction score model for the effective initiation of advance care planning. Performance status (PS) ≥2, hypoalbuminemia ≤2.5 g/dL and dementia were significant factors. The scoring model demonstrated 94.6% sensitivity and 61.7% specificity. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Discrepancies in preferences regarding the care of terminal-phase pneumonia in elderly patients among patients, families, and doctors: A multicenter questionnaire survey in nagasaki, Japan

Author

Takazono, Takahiro, Imamura, Yoshifumi, Kawakami, Kaoru, Yamasaki, Naoya, Shimizu, Hiroyoshi, Usuki, Katsuhiro, Kiyohara, Maiko, Hirayama, Tatsuro, Tashiro, Masato, Hosogaya, Naoki, Saijo, Tomomi, Yamamoto, Kazuko, Miyazaki, Taiga, Yanagihara, Katsunori, Izumikawa, Koichi, and Mukae, Hiroshi

Published
2020
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38. The efficacy and safety of sitafloxacin and garenoxacin for the treatment of pneumonia in elderly patients: A randomized, multicenter, open-label trial

Author

Miyazaki, Taiga, Nakamura, Shigeki, Hashiguchi, Kohji, Kobayashi, Tsutomu, Fukushima, Kiyoyasu, Fukuda, Yuichi, Kondo, Akira, Inoue, Yuichi, Koga, Hironobu, Sasaki, Eisuke, Nagayoshi, Yosuke, Higashiyama, Yasuhito, Yoshida, Masataka, Takazono, Takahiro, Saijo, Tomomi, Morinaga, Yoshitomo, Yamamoto, Kazuko, Imamura, Yoshifumi, Mikushi, Shinya, Izumikawa, Koichi, Yanagihara, Katsunori, Kohno, Shigeru, and Mukae, Hiroshi

Published
2019
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39. Efficacy and safety of cefditoren pivoxil for exacerbations of chronic obstructive pulmonary disease: A prospective multicenter interventional study

Author

Miyazaki, Taiga, Fukushima, Kiyoyasu, Hashiguchi, Kohji, Inoue, Yuichi, Mihara, Tomo, Sawai, Toyomitsu, Suyama, Naofumi, Kobayashi, Tsutomu, Kondo, Akira, Fukuda, Yuichi, Harada, Yosuke, Sasaki, Eisuke, Kaku, Norihito, Ide, Shotaro, Takazono, Takahiro, Saijo, Tomomi, Kosai, Kosuke, Morinaga, Yoshitomo, Nakamura, Shigeki, Yamamoto, Kazuko, Imamura, Yoshifumi, Izumikawa, Koichi, Yanagihara, Katsunori, Kohno, Shigeru, and Mukae, Hiroshi

Published
2019
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41. Comparison of rapid immunochromatographic assays using sputum and urine for Streptococcus pneumoniae detection in adult patients with respiratory tract infection

Author

Hirano, Katsuji, Tashiro, Masato, Takazono, Takahiro, Mihara, Tomo, Kohno, Yoshihisa, Kondo, Akira, Sawai, Toyomitsu, Hashiguchi, Kohji, Fukushima, Kiyoyasu, Inoue, Yuichi, Suyama, Naofumi, Izumikawa, Kinichi, Sato, Izumi, Yanagihara, Katsunori, Mukae, Hiroshi, Kohno, Shigeru, and Izumikawa, Koichi

Subjects
quantitative culture tests, BinaxNow, Streptococcus pneumoniae, RAPIRUN
Abstract

Aim: Streptococcus pneumoniae is the most frequently detected bacterium in pneumonia. RAPIRUN Streptococcus pneumoniae (RAPIRUN) using sputum and BinaxNow Streptococcus pneumoniae (BinaxNow) using urine have been used as rapid diagnostic methods for S. pneumoniae detection in Japan; however, their correlation with quantitative culture tests has not been well evaluated. Methods: A prospective study was conducted on adult patients with respiratory tract infections whose sputum and urine samples were available in six hospitals. Sputum and urine samples were tested at each site, and quantitative sputum cultures were performed. The performance of RAPIRUN and BinaxNow was compared in cases in which quantitative culture showed S. pneumoniae. Results: A total of 192 patients were analyzed. Of these, 167 were diagnosed with pneumonia (87.0%) including 161 of community-acquired pneumonia. Of the 192 cases, 86 (44.8%) were culture-proven for S. pneumoniae. There were 83 and 57 RAPIRUN- and BinaxNow-positive cases, respectively. The sensitivity and specificity of RAPIRUN were 84.9% and 90.6%, respectively, and those of BinaxNOW were 55.8% and 91.5%, respectively, indicating that RAPIRUN was significantly superior in sensitivity (p < 0.0001) with almost equal specificity (p = 0.317). Positive and negative percent agreements of both tests were 59.3% (κ, 0.114 [95% CI, 0.053–0.281]) and 99.1% (κ, 0.942 [95% CI, 0.830–1]), respectively, indicating they were well matched in specificity but not in sensitivity. The positivity rate of RAPIRUN increased with an increase in the number of bacteria (p< 0.0001) but not BinaxNow (p = 0.275). Conclusion: In adult patients with respiratory tract infections in whom sputum collection is feasible, RAPIRUN will increase the diagnostic efficacy of S. pneumoniae infection., Acta medica Nagasakiensia, 66(2), pp.71-79; 2023

Published
2023

43. Novel and potent antimicrobial effects of caspofungin on drug-resistant Candida and bacteria

Author

Sumiyoshi, Makoto, Miyazaki, Taiga, Makau, Juliann Nzembi, Mizuta, Satoshi, Tanaka, Yoshimasa, Ishikawa, Takeshi, Makimura, Koichi, Hirayama, Tatsuro, Takazono, Takahiro, Saijo, Tomomi, Yamaguchi, Hiroyuki, Shimamura, Shintaro, Yamamoto, Kazuko, Imamura, Yoshifumi, Sakamoto, Noriho, Obase, Yasushi, Izumikawa, Koichi, Yanagihara, Katsunori, Kohno, Shigeru, and Mukae, Hiroshi

Published
2020
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45. Human immunodeficiency virus-associated vacuolar encephalomyelopathy with granulomatous-lymphocytic interstitial lung disease improved after antiretroviral therapy: a case report

Author

Akagi, Kazumasa, Yamamoto, Kazuko, Umemura, Asuka, Ide, Shotaro, Hirayama, Tatsuro, Takazono, Takahiro, Imamura, Yoshifumi, Miyazaki, Taiga, Sakamoto, Noriho, Shiraishi, Hirokazu, Takahata, Hideaki, Zaizen, Yoshiaki, Fukuoka, Junya, Morikawa, Minoru, Ashizawa, Kazuto, Teruya, Katsuji, Izumikawa, Koichi, and Mukae, Hiroshi

Published
2020
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47. Detection of viral RNA in diverse body fluids in an SFTS patient with encephalopathy, gastrointestinal bleeding and pneumonia: a case report and literature review

Author

Akagi, Kazumasa, Miyazaki, Taiga, Oshima, Kazuhiro, Umemura, Asuka, Shimada, Satoshi, Morita, Kouichi, Senju, Hiroaki, Tashiro, Masato, Takazono, Takahiro, Saijo, Tomomi, Kurihara, Shintaro, Sekino, Motohiro, Yamamoto, Kazuko, Imamura, Yoshifumi, Izumikawa, Koichi, Yanagihara, Katsunori, Uda, Akihiko, Morikawa, Shigeru, Yoshikawa, Tomoki, Kurosu, Takeshi, Shimojima, Masayuki, Saijo, Masayuki, and Mukae, Hiroshi

Published
2020
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