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569 results on '"TESTA, FRANCESCO"'

12. A multidisciplinary approach to inherited retinal dystrophies from diagnosis to initial care: a narrative review with inputs from clinical practice

Author

Murro, Vittoria, Banfi, Sandro, Testa, Francesco, Iarossi, Giancarlo, Falsini, Benedetto, Sodi, Andrea, Signorini, Sabrina, Iolascon, Achille, Russo, Roberta, Mucciolo, Dario Pasquale, Caputo, Roberto, Bacci, Giacomo Maria, Bargiacchi, Sara, Turco, Simona, Fortini, Stefania, and Simonelli, Francesca

Published
2023
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15. Do Consumers Understand What Different Green Claims Actually Mean? An Experimental Approach in Italy.

Author

Iovino, Roberta, Testa, Francesco, and Iraldo, Fabio

Subjects
ENVIRONMENTAL literacy, CONSUMERS, CONSUMER behavior, STRUCTURAL equation modeling, PERCEPTION (Philosophy)
Abstract

This article extends the literature on consumers' responses to green claims and their intentions to buy green products. We used an experimental approach based on three complementary studies. The first compares the effects of two claims regarding different levels of a company's environmental commitment. The second examines whether consumers can recognize exaggerated claims. The third analyzes consumers' perceptions of a company's environmental commitment and intentions to buy the advertised product when an institutional methodology is used to substantiate the message. Surveys were administered online in January 2020 to samples of the Italian population aged 18 to 75. The results suggest that consumers positively perceive the commitment that lies behind all the conditions tested, strongly influencing intentions to buy. However, consumers have either little or no understanding of differences among green claims and are also easily deceived by exaggerated claims (such as "zero impact"). Using multigroup structural equation modeling (SEM), we highlight the important role of education. Consumers with a higher level of education are more receptive to claims that imply a higher commitment and appreciate the presence of an institutional methodology as a credibility signal. However, even highly educated consumers are likely to be deceived by exaggerated claims. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Efficacy, pharmacokinetics, and safety in the mouse and primate retina of dual AAV vectors for Usher syndrome type 1B

Author

Ferla, Rita, Dell’Aquila, Fabio, Doria, Monica, Ferraiuolo, Maria, Noto, Alessia, Grazioli, Fabiana, Ammendola, Virginia, Testa, Francesco, Melillo, Paolo, Iodice, Carolina, Risca, Giulia, Tedesco, Novella, le Brun, Pierre Romain, Surace, Enrico Maria, Simonelli, Francesca, Galimberti, Stefania, Valsecchi, Maria Grazia, Marteau, Jean-Brice, Veron, Philippe, Colloca, Stefano, and Auricchio, Alberto

Published
2023
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23. Genetic epidemiology of inherited retinal diseases in a large patient cohort followed at a single center in Italy

Author

Karali, Marianthi, Testa, Francesco, Di Iorio, Valentina, Torella, Annalaura, Zeuli, Roberta, Scarpato, Margherita, Romano, Francesca, Onore, Maria Elena, Pizzo, Mariateresa, Melillo, Paolo, Brunetti-Pierri, Raffaella, Passerini, Ilaria, Pelo, Elisabetta, Cremers, Frans P. M., Esposito, Gabriella, Nigro, Vincenzo, Simonelli, Francesca, and Banfi, Sandro

Published
2022
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30. Development and Validation of Empirical Formulations for Predicting the Frequency of Historic Masonry Towers.

Author

Testa, Francesco, Barontini, Alberto, and Lourenço, Paulo B.

Subjects
ARTIFICIAL neural networks, STONEMASONRY, MASONRY, DATABASES
Abstract

In the present work, a large database comprising a set of features related to geometry, type of boundary condition, type of material and experimental value of the first natural frequency for 184 historic masonry towers is collected. The database is then used to develop empirical formulas for the estimation of the fundamental frequency related to the first bending mode. The data are divided into a training set and a validation set for a correct assessment of the empirical equations, generated through power regression and artificial neural network. Different combinations of features are exploited as independent variables to investigate their influence on the dynamic behaviour of masonry towers. To improve the accuracy of the prediction, distinct models are generated for specific clusters with likely homogeneous behaviour, according to the boundary conditions (isolated or bounded) and type of materials (brick, stone or mixed masonry). [ABSTRACT FROM AUTHOR]

Published
2024
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31. The role of tourism in boosting circular transition: a measurement system based on a participatory approach.

Author

Gusmerotti, Natalia Marzia, Carlesi, Serena, Iannuzzi, Tiziana, and Testa, Francesco

Subjects
CIRCULAR economy, TOURISM, KEY performance indicators (Management), TOURIST attractions
Abstract

The growing interest in the circular economy poses a pivotal challenge for the tourism sector. A measurement framework is crucial for guiding the actors of the tourism sector in the development of a long-term strategy for a circular transition. Based on action research, where researchers and practitioners collaborate with each other, a co-created measurement framework was developed based on four types of capital and five circular economy principles. An assessment tool based on 54 Key Performance Indicators (KPIs) was then developed and tested in nine tourism destinations in the Mediterranean region. The framework was further fine-tuned through expert feedback and practitioners support, leading to the final Circular Measurement System for tourism destinations. This represents a solid and stakeholder-based measurement system to assess the circularity of tourism destinations, tangibly promoting the transition of the sector towards a circular economy. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Talk or walk? The board of directors and firm environmental strategies.

Author

Taglialatela, Jonathan, Miroshnychenko, Ivan, Barontini, Roberto, and Testa, Francesco

Subjects
BOARDS of directors, GREEN business, BUSINESS enterprises
Abstract

Drawing on legitimacy theory, we study the nexus between green communication and the implementation of green practices, and in particular, we focus on the determinants of their discrepancy. Based on a large sample of firms in 58 countries over a 19‐year period, we employ an index to measure the discrepancy between green operations and the communicated practices, mapped to each firm's board structure. The results provide the first empirical evidence that larger, more gender‐diverse, and more independent boards are associated with a preponderance of green communication over implementation. We interpret this imbalance as a strategy to participate in the public discourse to gain moral legitimacy. Conversely, CEO duality is associated with a discrepancy in the opposite direction, with firms focusing more on implementing green practices than talking about them, suggesting that these firms aim mainly at gaining pragmatic legitimacy from their stakeholders. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Late‐onset mucopolysaccharidosis type IIIA mimicking Usher syndrome.

Author

De Falco, Alessandro, Karali, Marianthi, Criscuolo, Chiara, Testa, Francesco, Barillari, Maria Rosaria, Scarpato, Margherita, Gaudieri, Valeria, Cuocolo, Alberto, Russo, Anna, Nigro, Vincenzo, Simonelli, Francesca, Banfi, Sandro, and Brunetti‐Pierri, Nicola

Abstract

Mucopolysaccharidosis type IIIA (MPS IIIA or Sanfilippo syndrome type A) is an autosomal recessive lysosomal storage disorder caused by pathogenic variants in the SGSH gene encoding N‐sulfoglucosamine sulfohydrolase, an enzyme involved in the degradation of heparan sulfate. MPS IIIA is typically characterized by neurocognitive decline and hepatosplenomegaly with childhood onset. Here, we report on a 53‐year‐old male subject initially diagnosed with Usher syndrome for the concurrence of retinitis pigmentosa and sensorineural hearing loss. Clinical exome sequencing identified biallelic missense variants in SGSH, and biochemical assays showed complete deficiency of sulfamidase activity and increased urinary glycosaminoglycan excretion. Reverse phenotyping revealed left ventricle pseudo‐hypertrophy, hepatosplenomegaly, bilateral deep white matter hyperintensities upon brain MRI, and decreased cortical metabolic activity by PET‐CT. On neuropsychological testing, the proband presented only partial and isolated verbal memory deficits. This case illustrates the power of unbiased, comprehensive genetic testing for the diagnosis of challenging mild or atypical forms of MPS IIIA. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Firms' Resilience During Crises as a Function of a Paradoxical Approach to Sustainability Tensions.

Author

Di Iorio, Vinicio, Testa, Francesco, Korschun, Daniel, and Bianchi, Guia

Abstract

The notion of sustainability, or "meeting the needs of the present without compromising the ability of future generations to meet their own needs," suggests inherent tensions and tradeoffs. Corporate sustainability initiatives require a delicate balance which make them quite susceptible to exogenous shocks. This paper examines the resiliency of firms' sustainability commitments in the face the Covid-19 pandemic. We contend that firms that exhibit more of a paradox approach to sustainability-related tensions are better equipped to handle competing demands and stark choices during such a crisis. This variance-based study examines interviews, internal company data, and external communications from 2018 to 2021, finding not only that firms with such a paradox approach were more resilient than peers but that some were able to use the crisis as a springboard for a deeper commitment (what we call transformational resilience). Furthermore, we trace the decision-making process through which firms with a paradox approach interlace absorptive and adaptive capabilities. The research contributes to the theory on resilience during a crisis by linking a paradox approach to strategy change and by challenging the notion that linear and deliberative decision making is always the best path to reconcile competing demands and tradeoffs. [ABSTRACT FROM AUTHOR]

Published
2024
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47. Biallelic sequence and structural variants in RAX2 are a novel cause for autosomal recessive inherited retinal disease

Author

Van de Sompele, Stijn, Smith, Claire, Karali, Marianthi, Corton, Marta, Van Schil, Kristof, Peelman, Frank, Cherry, Timothy, Rosseel, Toon, Verdin, Hannah, Derolez, Julien, Van Laethem, Thalia, Khan, Kamron N., McKibbin, Martin, Toomes, Carmel, Ali, Manir, Torella, Annalaura, Testa, Francesco, Jimenez, Belen, Simonelli, Francesca, De Zaeytijd, Julie, Van den Ende, Jenneke, Leroy, Bart P., Coppieters, Frauke, Ayuso, Carmen, Inglehearn, Chris F., Banfi, Sandro, and De Baere, Elfride

Published
2019
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