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1. P964: IMMUNOPHENOTYPED-SUSPENSION-MULTIPLEX FISH BY IMAGING FLOW CYTOMETRY FOR THE SIMULTANEOUS DIAGNOSIS OF THREE PIVOTAL IGH TRANSLOCATIONS IN MULTIPLE MYELOMA

Author: T. Tsukamoto, M. Kinoshita, K. Yamada, T. Yamaguchi, Y. Chinen, S. Mizutani, T. Fujino, Y. Shimura, T. Kobayashi, J. Inazawa, and J. Kuroda
Subjects: Diseases of the blood and blood-forming organs, RC633-647.5
Published: 2022
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2. P1127: WATCHFUL WAITING IS AN ACCEPTABLE TREATMENT OPTION FOR PRIMARY OCULAR ADNEXAL MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA: A RETROSPECTIVE STUDY

Author: K. Mizuhara, T. Kobayashi, M. Nakao, R. Takahashi, H. Kaneko, K. Shimura, K. Hirakawa, N. Uoshima, Y. Kamitsuji, K. Wada, E. Kawata, R. Isa, T. Fujino, Y. Matsumura-Kimoto, T. Tsukamoto, S. Mizutani, Y. Shimura, M. Taniwaki, and J. Kuroda
Subjects: Diseases of the blood and blood-forming organs, RC633-647.5
Published: 2022
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3. Experimental Study of $^{4}n$ by Directly Detecting the Decay Neutrons

Author: Atsumi Saito, Yohei Shimizu, H. Törnqvist, B. Monteagudo, T. Isobe, M. Caamaño, H. Scheit, S. Kiyotake, J. Tscheuschner, M. L. Cortés, F. M. Marqués, N. Fukuda, N. A. Orr, J. M. Gheller, A. Gillibert, A. Matta, K. Yoneda, L. Stuhl, Z. Elekes, I. Kuti, V. Wagner, M. Miwa, Z. Halász, A. Obertelli, S. Kim, A. Revel, L. Zanetti, N. L. Achouri, S. Takeuchi, F. Dufter, C. A. Douma, S. Masuoka, Stefanos Paschalis, R. Gernhäuser, S. Chen, Nobuyuki Chiga, S. Storck, T. Shimada, M.N. Harakeh, P. Koseoglou, T. Harada, B. Yang, M. Matsumoto, H. Takeda, D. S. Ahn, Yuya Kubota, H. Yamada, Yasuhiro Togano, A. Hirayama, Y. Yasuda, T. Fujino, D. M. Rossi, Nasser Kalantar-Nayestanaki, J. Tanaka, M. Böhmer, N. Inabe, Didier Beaumel, S. Park, Thomas Aumann, H. Baba, Tomohiro Uesaka, F. Schindler, J. Feng, Zaihong Yang, I. Murray, Julien Gibelin, K. Boretzky, S. W. Huang, B. Fernández-Domínguez, S. Reichert, Takashi Nakamura, Yu-xin Liu, K. Wimmer, Yukie Maeda, L. Yang, H. Sato, E. Tronchin, P. Doornenbal, Dmytro Symochko, D. Cortina, J. Kahlbow, S. Shimoura, H. Suzuki, Hideaki Otsu, M. Potlog, P. J. Li, J. Mayer, H. Miki, Masaki Sasano, Toshio Kobayashi, Z. Ge, D. Kim, Juzo Zenihiro, T. Tomai, I. Stefan, M. Parlog, H. Simon, V. Panin, Igor Gašparić, C. Lehr, Yosuke Kondo, C. Lenain, U. Forsberg, Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Research unit Nuclear & Hadron Physics, and Nuclear Energy
Subjects: Nuclear structure and force, tetraneutron, direct reactions, radioactive beams, Physics, Nuclear physics, 010308 nuclear & particles physics, 0103 physical sciences, Tetraneutron, Neutron, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 010306 general physics, 01 natural sciences, Atomic and Molecular Physics, and Optics, 3. Good health
Abstract: The tetraneutron has attracted the attention of nuclear physicists during the past decades, but there is still no unambiguous confirmation of its existence or non-existence. A new experiment based on $$^{8}$$ He(p, 2p) $$^{7}$$ H{t+ $$^{4}n$$ } reaction, with direct detection of the four neutrons, has been carried out at RIBF, which can hopefully help to draw a definite conclusion on the tetraneutron system.
Published: 2021
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4. Results of gravitational lensing and primordial gravitational waves from the POLARBEAR experiment

Author: Peter A. R. Ade, Davide Poletti, C. Verges, Shunsuke Adachi, Kam Arnold, Yuji Chinone, A. Suzuki, Yuto Minami, Chang Feng, J. Peloton, Nathan Whitehorn, Oliver Jeong, N. W. Halverson, Yuki Inoue, T. Hamada, Akito Kusaka, Y. Zhou, A. Zahn, A. Cukierman, M. Aguilar, Carole Tucker, D. Beck, Nicoletta Krachmalnicoff, Rolando Dünner, Brian Keating, Paul L. Richards, Stephen M. Feeney, J. C. Groh, Julian Borrill, C. Tsai, Joshua Montgomery, Darcy Barron, Theodore Kisner, R. Stompor, G. Hall, D. Boettger, Tucker Elleflot, Josquin Errard, Frederick Matsuda, L. N. Lowry, D. Leon, Takayuki Tomaru, Reijo Keskitalo, Benjamin Westbrook, M. Navaroli, D. Kaneko, K. Cheung, Osamu Tajima, A. T. P. Pham, Eric V. Linder, Giulio Fabbian, A. J. Gilbert, L. Howe, Neil Goeckner-Wald, H. El-Bouhargani, Max Silva-Feaver, Hans P. Paar, M. A. Dobbs, S. Takatori, Federico Bianchini, Colin Ross, Christian L. Reichardt, John Groh, Praween Siritanasak, Julien Carron, Tomotake Matsumura, T. Fujino, Y. Akiba, H. Nishino, G. Jaehnig, Giuseppe Puglisi, Charles A. Hill, D. Tanabe, Andrew H. Jaffe, Masashi Hazumi, Nicholas Galitzki, Blake D. Sherwin, S. Kikuchi, Carlo Baccigalupi, E. M. Leitch, S. Beckman, N. Katayama, Grant Teply, A. Ducout, Aashrita Mangu, M. LeJeune, Adrian T. Lee, Nathan Stebor, Masaya Hasegawa, S. Takakura, Y. Segawa, Scott Chapman, Kevin T. Crowley, Chinone, Y, Adachi, S, Ade, P, Aguilar, M, Akiba, Y, Arnold, K, Baccigalupi, C, Barron, D, Beck, D, Beckman, S, Bianchini, F, Boettger, D, Borrill, J, Elbouhargani, H, Carron, J, Chapman, S, Cheung, K, Crowley, K, Cukierman, A, Dunner, R, Dobbs, M, Ducout, A, Elleflot, T, Errard, J, Fabbian, G, Feeney, S, Feng, C, Fujino, T, Galitzki, N, Gilbert, A, Goeckner-Wald, N, Groh, J, Hall, G, Halverson, N, Hamada, T, Hasegawa, M, Hazumi, M, Hill, C, Howe, L, Inoue, Y, Jaehnig, G, Jaffe, A, Jeong, O, Lejeune, M, Kaneko, D, Katayama, N, Keating, B, Keskitalo, R, Kikuchi, S, Kisner, T, Krachmalnicoff, N, Kusaka, A, Lee, A, Leitch, E, Leon, D, Linder, E, Lowry, L, Mangu, A, Matsuda, F, Matsumura, T, Minami, Y, Montgomery, J, Navaroli, M, Nishino, H, Paar, H, Peloton, J, Pham, A, Poletti, D, Puglisi, G, Reichardt, C, Richards, P, Ross, C, Segawa, Y, Sherwin, B, Silva-Feaver, M, Siritanasak, P, Stebor, N, Stompor, R, Suzuki, A, Tajima, O, Takakura, S, Takatori, S, Tanabe, D, Teply, G, Tomaru, T, Tsai, C, Tucker, C, Verges, C, Westbrook, B, Whitehorn, N, Zahn, A, Zhou, Y, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), POLARBEAR, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)
Subjects: History, satellite: Planck, Cosmic microwave background, gravitational lensing, cosmic background radiation: polarization, detector: noise, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Gravity waves, power spectrum, 01 natural sciences, Education, Primary mirror, symbols.namesake, Settore FIS/05 - Astronomia e Astrofisica, gravitation: lens, Polarization, 0103 physical sciences, Planck, mirror, 010303 astronomy & astrophysics, Physics, COSMIC cancer database, 010308 nuclear & particles physics, Gravitational wave, Settore FIS/05, POLARBEAR experiment, Gravitational effects, gravitational radiation: primordial, Astrophysics::Instrumentation and Methods for Astrophysics, Polarization (waves), Galaxy, Computer Science Applications, Gravitational lens, B-mode, symbols, [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], galaxy
Abstract: POLARBEAR is a Cosmic Microwave Background radiation (CMB) polarization experiment that is located in the Atacama Desert in Chile. The scientific goals of the experiment are to characterize the B-mode signal from gravitational lensing, as well as to search for B-mode signals created by primordial gravitational waves (PGWs). Polarbear started observations in 2012 and has published a series of results. These include the first measurement of a nonzero B-mode angular auto-power spectrum at sub-degree scales where the dominant signal is gravitational lensing of the CMB. In addition, we have achieved the first measurement of crosscorrelation between the lensing potential, which was reconstructed from the CMB polarization data alone by Polarbear, and the cosmic shear field from galaxy shapes by the Subaru Hyper Suprime-Cam (HSC) survey. In 2014, we installed a continuously rotating half-wave plate (CRHWP) at the focus of the primary mirror to search for PGWs and demonstrated the control of low-frequency noise. We have found that the low-frequency B-mode power in the combined dataset with the Planck high-frequency maps is consistent with Galactic dust foreground, thus placing an upper limit on the tensor-to-scalar ratio of r < 0.90 at the 95% confidence level after marginalizing over the foregrounds.
Published: 2020
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5. Experimental study of 4 n with 8He(p,2p) reaction

Author: M. Böhmer, Masaki Sasano, S. Reichert, Naohito Inabe, S. Chen, T. Shimada, M. Matsumoto, Susumu Shimoura, I. Stefan, J. Kahlbow, N. Kalantar-Nayestanaki, T. Harada, D. Symochko, István Kuti, S. W. Huang, D. Cortina, Tomohiro Uesaka, Z. Ge, N. L. Achouri, Yosuke Kondo, Hiroyuki Takeda, K. Yoneda, B. Fernández-Domínguez, U. Forsberg, Z. Elekes, Roman Gernhäuser, Y. Yasuda, H. Suzuki, Yohei Shimizu, D. Beaumel, D. Kim, C. A. Douma, Yukie Maeda, A. Hirayama, J. M. Gheller, Heiko Scheit, F. Dufter, T. Elidiano, Yasuhiro Togano, M. L. Cortés, M. Potlog, Nobuyuki Chiga, P. J. Li, Juzo Zenihiro, B. Yang, T. Isobe, M. Caamaño, Thomas Aumann, H. T. Törnqvsit, A. Gillibert, D. S. Ahn, F. Schindler, M.N. Harakeh, J. Feng, J. Tscheuschner, S. Kim, Atsumi Saito, L. Zanetti, P. Koseoglou, V. Wagner, M. Parlog, B. M. Godoy, N. Orr, Takashi Nakamura, Yu-xin Liu, J. Mayer, A. Obertelli, Yuya Kubota, Hideaki Otsu, S. Storck, S. Masuoka, K. Boretzky, Kathrin Wimmer, H. Miki, T. Tomai, F. M. Marqués, V. Panin, P. Doornenbal, Stefanos Paschalis, L. Yang, Satoshi Takeuchi, M. A. Knösel, Igor Gašparić, T. Kobayashi, C. Lehr, H. Yang, C. Lenain, M. Miwa, Z. Halász, A. Revel, H. Sato, T. Fujino, D. M. Rossi, H. Baba, S. Park, I. Murray, L. Stuhl, H. Yamada, J. Gibelin, J. Tanaka, Naoki Fukuda, RIKEN Nishina Center for Accelerator-Based Science, German Research Foundation, Federal Ministry of Education and Research (Germany), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), and Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)
Subjects: Physics, Paper, History, 010308 nuclear & particles physics, tetraneutron, nuclear force, proton knock-out, radioactive beams, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, Computer Science Applications, Education, ddc, Nuclear physics, 0103 physical sciences, Tetraneutron, Neutron, ddc:530, 010306 general physics
Abstract: 7 pags., 3 figs. -- 27th International Nuclear Physics Conference (INPC2019), The tetraneutron has attracted the attention of nuclear physicists during the past decades, but there is still no unambiguous confirmation of its existence or nonexistence. A new experiment based on 8 He(p,2p)7H{t+4n} reaction, with direct detection of the four neutrons, has been carried out at RIBF, which can hopefully help to draw a definite conclusion on the tetraneutron system., We acknowledge the support of the RIBF accelerator staff and the BigRIPS team for providing the high-quality beam. Z. H. Yang acknowledges the financial support from the Foreign Postdoctoral Researcher program of RIKEN. T. Aumann acknowledges the support by DFG via SFB 1245. P. Koseoglou acknowledges the support from BMBF (NUSTAR.DA grant No.05P 15RDFN1).
Published: 2020
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6. Internal delensing of cosmic microwave background polarization B-modes with the POLARBEAR experiment

Author: Kam Arnold, Grant Teply, D. Leon, R. Stompor, Neil Goeckner-Wald, Yuji Chinone, D. Beck, J. Borrill, H. El Bouhargani, Kevin T. Crowley, S. Takatori, Toshiya Namikawa, M. A. O. Aguilar Faúndez, Max Silva-Feaver, M. Navaroli, Christian L. Reichardt, J. Peloton, Tucker Elleflot, Josquin Errard, Darcy Barron, Davide Poletti, Osamu Tajima, K. Cheung, C. Verges, L. N. Lowry, N. Katayama, Federico Bianchini, Eric V. Linder, Giulio Fabbian, Praween Siritanasak, Yuto Minami, Brian Keating, Julien Carron, L. Howe, Shunsuke Adachi, Tomotake Matsumura, A. T. P. Pham, Y. Segawa, Carlo Baccigalupi, Aamir Ali, Akito Kusaka, Masaya Hasegawa, Frederick Matsuda, Aaron Lee, Chang Feng, Giuseppe Puglisi, Charles A. Hill, T. Fujino, Y. Akiba, D. Tanabe, S. Kikuchi, H. Nishino, Masashi Hazumi, Blake D. Sherwin, AstroParticule et Cosmologie (APC (UMR_7164)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), POLARBEAR, Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Adachi, S, Aguilar Faundez, M, Akiba, Y, Ali, A, Arnold, K, Baccigalupi, C, Barron, D, Beck, D, Bianchini, F, Borrill, J, Carron, J, Cheung, K, Chinone, Y, Crowley, K, El Bouhargani, H, Elleflot, T, Errard, J, Fabbian, G, Feng, C, Fujino, T, Goeckner-Wald, N, Hasegawa, M, Hazumi, M, Hill, C, Howe, L, Katayama, N, Keating, B, Kikuchi, S, Kusaka, A, Lee, A, Leon, D, Linder, E, Lowry, L, Matsuda, F, Matsumura, T, Minami, Y, Namikawa, T, Navaroli, M, Nishino, H, Peloton, J, Pham, A, Poletti, D, Puglisi, G, Reichardt, C, Segawa, Y, Sherwin, B, Silva-Feaver, M, Siritanasak, P, Stompor, R, Tajima, O, Takatori, S, Tanabe, D, Teply, G, Verges, C, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), APC - Cosmologie, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Cosmology and Nongalactic Astrophysics (astro-ph.CO), Cosmic Microwave Background Polarization, Cosmic microwave background, FOS: Physical sciences, General Physics and Astronomy, cosmic background radiation: polarization, General Relativity and Quantum Cosmology (gr-qc), Gravitation and Astrophysics, 01 natural sciences, General Relativity and Quantum Cosmology, B-mode: primordial, Settore FIS/05 - Astronomia e Astrofisica, QB0980, 0103 physical sciences, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, Instrumentation and Methods for Astrophysics (astro-ph.IM), QC, QB, Physics, Settore FIS/05, Polarization (waves), inflation: model, Computational physics, POLARBEAR Experiment, [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], Instrumentation and Methods for Astrophysics, Variance reduction, Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: Using only cosmic microwave background polarization data from the POLARBEAR experiment, we measure $B$-mode polarization delensing on subdegree scales at more than $5\sigma$ significance. We achieve a 14% $B$-mode power variance reduction, the highest to date for internal delensing, and improve this result to 2% by applying for the first time an iterative maximum a posteriori delensing method. Our analysis demonstrates the capability of internal delensing as a means of improving constraints on inflationary models, paving the way for the optimal analysis of next-generation primordial $B$-mode experiments., Comment: Matches version published in Physical Review Letters
Published: 2019
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7. A Measurement of the Degree Scale CMB B-mode Angular Power Spectrum with POLARBEAR

Author: Julien Carron, M. A. Dobbs, C. Tsai, Dominic Beck, D. Leon, Ted Kisner, Aashrita Mangu, D. Boettger, Christian L. Reichardt, A. T. P. Pham, Kam Arnold, Akito Kusaka, Nicoletta Krachmalnicoff, T. Hamada, John Groh, S. Beckman, Josquin Errard, Ben Westbrook, Nathan Stebor, Neil Goeckner-Wald, Reijo Keskitalo, Daisuke Kaneko, Greg Jaehnig, Kevin T. Crowley, S. Takatori, Masaya Hasegawa, D. Tanabe, Tucker Elleflot, Giulio Fabbian, L. Howe, A. Cukierman, T. Fujino, Y. Zhou, S. Takakura, Eric V. Linder, Julian Borrill, N. Katayama, Yuki Inoue, Davide Poletti, Praween Siritanasak, Haruki Nishino, Yuto Minami, Yuji Chinone, Y. Segawa, H. El Bouhargani, Osamu Tajima, Aritoki Suzuki, N. W. Halverson, Darcy Barron, Masashi Hazumi, L. N. Lowry, G. Hall, Frederick Matsuda, Federico Bianchini, Scott Chapman, M. Navaroli, R. Stompor, Nicholas Galitzki, Clara Vergès, Maximiliano Silva-Feaver, Oliver Jeong, M. A. O. Aguilar Faúndez, Grant Teply, Brian Keating, Shunsuke Adachi, S. Kikuchi, K. Cheung, Adrian T. Lee, Giuseppe Puglisi, Charles A. Hill, Chang Feng, C. Baccigalupi, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), POLARBEAR, Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Adachi, S, Aguilar Faundez, M, Arnold, K, Baccigalupi, C, Barron, D, Beck, D, Beckman, S, Bianchini, F, Boettger, D, Borrill, J, Carron, J, Chapman, S, Cheung, K, Chinone, Y, Crowley, K, Cukierman, A, Dobbs, M, Bouhargani, H, Elleflot, T, Errard, J, Fabbian, G, Feng, C, Fujino, T, Galitzki, N, Goeckner-Wald, N, Groh, J, Hall, G, Halverson, N, Hamada, T, Hasegawa, M, Hazumi, M, Hill, C, Howe, L, Inoue, Y, Jaehnig, G, Jeong, O, Kaneko, D, Katayama, N, Keating, B, Keskitalo, R, Kikuchi, S, Kisner, T, Krachmalnicoff, N, Kusaka, A, Lee, A, Leon, D, Linder, E, Lowry, L, Mangu, A, Matsuda, F, Minami, Y, Navaroli, M, Nishino, H, Pham, A, Poletti, D, Puglisi, G, Reichardt, C, Segawa, Y, Silva-Feaver, M, Siritanasak, P, Stebor, N, Stompor, R, Suzuki, A, Tajima, O, Takakura, S, Takatori, S, Tanabe, D, Teply, G, Tsai, C, Verges, C, Westbrook, B, Zhou, Y, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), APC - Cosmologie, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Cosmic microwave background radiation, Cosmic inflation, Cosmology, Observational cosmology, cosmological model, 010504 meteorology & atmospheric sciences, Cosmic microwave background, Astrophysics, 01 natural sciences, Atomic, Physical Chemistry, Spectral line, thermal, Cosmic microwave background radiationCosmic inflationCosmologyObservational cosmology, Particle and Plasma Physics, polarization: power spectrum, 010303 astronomy & astrophysics, media_common, Physics, Settore FIS/05, Polarization (waves), symbols, astro-ph.CO, power spectrum: angular dependence, Astronomical and Space Sciences, Physical Chemistry (incl. Structural), Astrophysics - Cosmology and Nongalactic Astrophysics, data analysis method, noise, Cosmology and Nongalactic Astrophysics (astro-ph.CO), satellite: Planck, media_common.quotation_subject, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, Astronomy & Astrophysics, frequency: high, cosmic background radiation: B-mode, symbols.namesake, Settore FIS/05 - Astronomia e Astrofisica, gravitation: lens, statistical analysis, 0103 physical sciences, Nuclear, Planck, cosmic background radiation: power spectrum, inflation, 0105 earth and related environmental sciences, gravitational radiation: primordial, gravitational radiation, Spectral density, Molecular, Astronomy and Astrophysics, Square degree, detector: sensitivity, Space and Planetary Science, Sky, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: We present a measurement of the $B$-mode polarization power spectrum of the cosmic microwave background (CMB) using taken from July 2014 to December 2016 with the POLARBEAR experiment. The CMB power spectra are measured using observations at 150 GHz with an instantaneous array sensitivity of $\mathrm{NET}_\mathrm{array}=23\, \mu \mathrm{K} \sqrt{\mathrm{s}}$ on a 670 square degree patch of sky centered at (RA, Dec)=($+0^\mathrm{h}12^\mathrm{m}0^\mathrm{s},-59^\circ18^\prime$). A continuously rotating half-wave plate is used to modulate polarization and to suppress low-frequency noise. We achieve $32\,\mu\mathrm{K}$-$\mathrm{arcmin}$ effective polarization map noise with a knee in sensitivity of $\ell = 90$, where the inflationary gravitational wave signal is expected to peak. The measured $B$-mode power spectrum is consistent with a $\Lambda$CDM lensing and single dust component foreground model over a range of multipoles $50 \leq \ell \leq 600$. The data disfavor zero $C_\ell^{BB}$ at $2.2\sigma$ using this $\ell$ range of POLARBEAR data alone. We cross-correlate our data with Planck high frequency maps and find the low-$\ell$ $B$-mode power in the combined dataset to be consistent with thermal dust emission. We place an upper limit on the tensor-to-scalar ratio $r < 0.90$ at 95% confidence level after marginalizing over foregrounds.
Published: 2019
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8. Increasing heart transplant donor pool by liberalization of size matching

Author: Valluvan Jeevanandam, Jayant Raikhelkar, Nikhil Narang, Tae Song, Teruhiko Imamura, Luise Holzhauser, T. Fujino, D. Nitta, David Onsager, Anthony J. Kanelidis, Nir Uriel, Gene Kim, Nikhil Bassi, C. Murks, Gabriel Sayer, and Takeyoshi Ota
Subjects: Pulmonary and Respiratory Medicine, Adult, Male, medicine.medical_specialty, Time Factors, Tissue and Organ Procurement, medicine.medical_treatment, Diastole, Cardiac index, Hemodynamics, 030204 cardiovascular system & hematology, 030230 surgery, Article, Donor Selection, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Donor pool, Retrospective Studies, Heart transplantation, Transplantation, business.industry, Heart, Organ Size, Length of Stay, Middle Aged, Size matching, Survival Rate, Size mismatch, Cohort, Cardiology, Heart Transplantation, Surgery, Female, Cardiology and Cardiovascular Medicine, business
Abstract: BACKGROUND: The heart transplant (HT) guidelines recommendation to match recipient and donors within 30% of body weight lacks a strong evidence base and is not well established in patients bridged to transplant with left ventricular assist devices (LVAD). In light of the scarcity of donor hearts, we investigated the effect of size mismatch on hemodynamics, one-year survival and length of stay (LOS) following HT. METHODS: Single-center retrospective analysis of consecutive HT patients from April 2007 to September 2017. Recipients were divided into 3 cohorts based on donor-to-recipient weight ratio (DRWR): (1) undersized (1.3). RESULTS: 288 consecutive patients were identified (mean age 53 ± 11 years; 76% male), 46 were undersized (0.61 ± 0.05), 210 size-matched (0.94 ± 0.16), and 32 oversized (1.65 ± 0.38). There was no significant difference in donor left ventricular end diastolic diameter (LVEDD) between the 3 groups (p = 0.11). The donor/recipient (D/R) predicted heart mass (PHM) was lowest in the undersized group (0.92 ± 0.13). There were no significant differences in 1-year survival in the overall and LVAD cohort (p = 0.65 and 0.59, respectively). Neither donor LVEDD nor D/R PHM differed among survivors or non-survivors. LOS was longer in the undersized group than the size-matched cohort (p = 0.004). The undersized group had hearts with the highest filling pressures and lowest cardiac index at 1 week among the remaining groups (p = 0.009, 0.017, and p = 0.05, respectively). There were no clinically significant differences in hemodynamics at 1 or 6 months. CONCLUSIONS: HT undersizing affects hemodynamics early but not later in the course and does not impact 1-year survival. The liberalization of size matching may increase the HT donor pool significantly.
Published: 2019

9. Aortic Insufficiency and Hemocompatibility-related Adverse Events in Patients with Left Ventricular Assist Devices

Author: Bryan Smith, Gene Kim, Nikhil Narang, T. Fujino, Teruhiko Imamura, D. Nitta, Nir Uriel, Valluvan Jeevanandam, Takeyoshi Ota, Sara Kalantari, Ann Nguyen, Tae Song, Luise Holzhauser, Daniel Rodgers, Jonathan Grinstein, Colleen Juricek, and Gabriel Sayer
Subjects: Male, medicine.medical_specialty, Aortic Valve Insufficiency, Diastole, Hemodynamics, Regurgitation (circulation), 030204 cardiovascular system & hematology, Doppler echocardiography, Severity of Illness Index, Article, Ventricular Function, Left, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Materials Testing, medicine, Humans, 030212 general & internal medicine, Adverse effect, Retrospective Studies, Heart Failure, medicine.diagnostic_test, business.industry, Hemodynamic Monitoring, Atrial fibrillation, Middle Aged, medicine.disease, Cannula, Echocardiography, Doppler, United States, Heart failure, Cardiology, Female, Heart-Assist Devices, Cardiology and Cardiovascular Medicine, business
Abstract: AIM: Hemocompatibility-related adverse events (HRAE) are a major cause of readmissions in patients with left ventricular assist devices (LVAD). The impact of aortic insufficiency (AI) on HRAE remains uncertain. We aimed to investigate the impact of AI on HRAE. METHODS AND RESULTS: Patients who underwent LVAD implantation between August 2014 and July 2017 and had echocardiograms 3 months post-LVAD implantation were enrolled. AI severity was assessed by measuring the systolic/diastolic ratio of flow and the rate of diastolic flow acceleration using Doppler echocardiography of the outflow cannula. Regurgitation fraction was derived from these parameters. Significant AI was defined as regurgitation fraction > 30%. Among 105 patients (median age, 56 years; 76% male), 36 patients (34%) had significant AI. Baseline characteristics were statistically not significantly different between those with and without significant AI except for higher rates of ischemic etiology and atrial fibrillation in the significant AI group (P < 0.05 for both). One-year survival free from HRAE was 44% in patients with AI compared to 67% in patients without significant AI (P = 0.018). The average hemocompatibility score, which defines the net burden of HRAE, was higher in the AI group (1.72 vs 0.64; P = 0.009), due mostly to higher tier I (mild HRAE; P = 0.034) and tier IIIB scores (severe HRAE; P = 0.011). CONCLUSION: Significant AI, as assessed by Doppler echocardiographic parameters, was associated with HRAE during LVAD support. (J Cardiac Fail 2019;00:1–8)
Published: 2019

10. Deployment of Polarbear-2A

Author: Chang Feng, Radek Stompor, Takayuki Tomaru, Rolando Dünner, Josquin Errard, D. Tanabe, Praween Siritanasak, N. Stebor, Julien Carron, D. Leon, Davide Poletti, K. Cheung, C. Tsai, S. Takakura, Grant Teply, Yuto Minami, Yuki Inoue, Stephen M. Feeney, Yuji Chinone, Frederick Matsuda, D. Beck, Akito Kusaka, Y. Akiba, A. Suzuki, Nicoletta Krachmalnicoff, Adrian T. Lee, M. Aguilar Faúndez, J. Peloton, Colin Ross, Osamu Tajima, D. Boettger, B. Westbrook, A. T. P. Pham, M. Navaroli, N. W. Halverson, Y. Zhou, Federico Bianchini, A. Cukierman, Aashrita Mangu, Nobuhiko Katayama, T. Hamada, Tucker Elleflot, Y. Segawa, Masaya Hasegawa, G. Hall, Julian Borrill, Peter A. R. Ade, Eric V. Linder, Giulio Fabbian, H. Nishino, G. Jaehnig, Giuseppe Puglisi, Charles A. Hill, Shunsuke Adachi, S. Takatori, L. Howe, A. J. Gilbert, H. El-Bouhargani, Christian L. Reichardt, Kam Arnold, John Groh, Masashi Hazumi, Neil Goeckner-Wald, Nicholas Galitzki, S. Beckman, Brian Keating, M. A. Dobbs, Carlo Baccigalupi, Clara Vergès, Theodore Kisner, Reijo Keskitalo, Daisuke Kaneko, T. Fujino, S. Kikuchi, Darcy Barron, L. N. Lowry, Scott Chapman, Maximiliano Silva-Feaver, Oliver Jeong, Kevin T. Crowley, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Kaneko, D, Adachi, S, Ade, P, Aguilar Faundez, M, Akiba, Y, Arnold, K, Baccigalupi, C, Barron, D, Beck, D, Beckman, S, Bianchini, F, Boettger, D, Borrill, J, Carron, J, Chapman, S, Cheung, K, Chinone, Y, Crowley, K, Cukierman, A, Dobbs, M, Dunner, R, El-Bouhargani, H, Elleflot, T, Errard, J, Fabbian, G, Feeney, S, Feng, C, Fujino, T, Galitzki, N, Gilbert, A, Goeckner-Wald, N, Groh, J, Hall, G, Halverson, N, Hamada, T, Hasegawa, M, Hazumi, M, Hill, C, Howe, L, Inoue, Y, Jaehnig, G, Jeong, O, Katayama, N, Keating, B, Keskitalo, R, Kikuchi, S, Kisner, T, Krachmalnicoff, N, Kusaka, A, Lee, A, Leon, D, Linder, E, Lowry, L, Mangu, A, Matsuda, F, Minami, Y, Navaroli, M, Nishino, H, Peloton, J, Pham, A, Poletti, D, Puglisi, G, Reichardt, C, Ross, C, Segawa, Y, Silva-Feaver, M, Siritanasak, P, Stebor, N, Stompor, R, Suzuki, A, Tajima, O, Takakura, S, Takatori, S, Tanabe, D, Teply, G, Tomaru, T, Tsai, C, Verges, C, Westbrook, B, Zhou, Y, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)
Subjects: [PHYS]Physics [physics], Settore FIS/05, Gravitational wave, Cosmic microwave background, Millimeter wave, First light, CMB, Condensed Matter Physics, 7. Clean energy, 01 natural sciences, Atomic and Molecular Physics, and Optics, 010305 fluids & plasmas, Microwave emission, Settore FIS/05 - Astronomia e Astrofisica, TES bolometer, Planet, Software deployment, 0103 physical sciences, Extremely high frequency, B-mode polarization, General Materials Science, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Remote sensing
Abstract: International audience; Polarbear-2A is the first of three receivers in the Simons array, a cosmic microwave background experiment located on the Atacama Plateau in Chile. Polarbear-2A was deployed and achieved the first light in January 2019 by mapping the microwave emission from planet observations. Commissioning work is underway to prepare the receiver for science observations.
Published: 2019
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11. Study of multi-neutron systems with SAMURAI spectrometer

Author: K. Yoneda, Z. Elekes, Masaki Sasano, Heiko Scheit, Atsumi Saito, N. Inabe, I. Stefan, J. Tscheuschner, Mohsen Harakeh, Julien Gibelin, M. A. Knösel, K. Boretzky, Z. Ge, Takashi Nakamura, D. Kim, H. Sato, J. Kahlbow, Igor Gašparić, Y. Yasuda, Susumu Shimoura, T. Isobe, Juzo Zenihiro, M. Caamaño, Yosuke Kondo, S. Masuoka, H. Suzuki, A. Hirayama, S. W. Huang, C. A. Douma, B. M. Godoy, Z. Halász, H. Yamada, C. Lehr, M. Böhmer, Nobuyuki Chiga, A. Revel, N. L. Achouri, P. Koseoglou, Kathrin Wimmer, V. Wagner, N. A. Orr, M. Potlog, M. Miwa, B. Yang, A. Obertelli, T. Harada, H. T. Törnqvsit, S. Reichert, H. Miki, D. S. Ahn, T. Tomai, István Kuti, J. Mayer, J. Tanaka, S. Park, Yasuhiro Togano, M. Parlog, Naoki Fukuda, Yu-xin Liu, S. Chen, V. Panin, L. Zanetti, F. Schindler, S. Storck, T. Shimada, Tomohiro Uesaka, J. Feng, M. Matsumoto, Zaihong Yang, U. Forsberg, Roman Gernhäuser, I. Murray, F. Dufter, D. Symochko, L. Stuhl, J. M. Gheller, Hideaki Otsu, D. Beaumel, T. Kobayashi, H. Takeda, A. Gillibert, D. Cortina, P. Doornenbal, L. Yang, Nasser Kalantar-Nayestanaki, Satoshi Takeuchi, Thomas Aumann, Stefanos Paschalis, T. Fujino, D. M. Rossi, H. Baba, Yohei Shimizu, M. L. Cortés, F. M. Marqués, B. Fernández-Domínguez, Yuya Kubota, Yukie Maeda, S. K. Kim, P. J. Li, Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), and Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)
Subjects: Physics, Firm conclusion, Spectrometer, FOS: Physical sciences, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, 010305 fluids & plasmas, Nuclear physics, 0103 physical sciences, Tetraneutron, Neutron, Nuclear Experiment (nucl-ex), 010306 general physics, Nuclear Experiment
Abstract: The tetraneutron has been drawing the attention of the nuclear physics community for decades, but a firm conclusion on its existence and properties is still far from being reached despite many experimental and theoretical efforts. New measurements have recently been performed at RIBF with the SAMURAI spectrometer by applying complementary reaction probes, which will help to pin down the properties of this four-neutron system., Comment: 5 pages, 2 figures, conference proceedings of XXII International Conference on Few-Body Problems in Physics (FB22), Caen, France, July 2018
Published: 2018
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12. The LiteBIRD Satellite Mission: Sub-Kelvin Instrument

Author: A. Suzuki, P. A. R. Ade, Y. Akiba, D. Alonso, K. Arnold, J. Aumont, C. Baccigalupi, D. Barron, S. Basak, S. Beckman, J. Borrill, F. Boulanger, M. Bucher, E. Calabrese, Y. Chinone, S. Cho, B. Crill, A. Cukierman, D. W. Curtis, T. de Haan, M. Dobbs, A. Dominjon, T. Dotani, L. Duband, A. Ducout, J. Dunkley, J. M. Duval, T. Elleflot, H. K. Eriksen, J. Errard, J. Fischer, T. Fujino, T. Funaki, U. Fuskeland, K. Ganga, N. Goeckner-Wald, J. Grain, N. W. Halverson, T. Hamada, T. Hasebe, M. Hasegawa, K. Hattori, M. Hattori, L. Hayes, M. Hazumi, N. Hidehira, C. A. Hill, G. Hilton, J. Hubmayr, K. Ichiki, T. Iida, H. Imada, M. Inoue, Y. Inoue, K. D. Irwin, H. Ishino, O. Jeong, H. Kanai, D. Kaneko, S. Kashima, N. Katayama, T. Kawasaki, S. A. Kernasovskiy, R. Keskitalo, A. Kibayashi, Y. Kida, K. Kimura, T. Kisner, K. Kohri, E. Komatsu, K. Komatsu, C. L. Kuo, N. A. Kurinsky, A. Kusaka, A. Lazarian, A. T. Lee, D. Li, E. Linder, B. Maffei, A. Mangilli, M. Maki, T. Matsumura, S. Matsuura, D. Meilhan, S. Mima, Y. Minami, K. Mitsuda, L. Montier, M. Nagai, T. Nagasaki, R. Nagata, M. Nakajima, S. Nakamura, T. Namikawa, M. Naruse, H. Nishino, T. Nitta, T. Noguchi, H. Ogawa, S. Oguri, N. Okada, A. Okamoto, T. Okamura, C. Otani, G. Patanchon, G. Pisano, G. Rebeiz, M. Remazeilles, P. L. Richards, S. Sakai, Y. Sakurai, Y. Sato, N. Sato, M. Sawada, Y. Segawa, Y. Sekimoto, U. Seljak, B. D. Sherwin, T. Shimizu, K. Shinozaki, R. Stompor, H. Sugai, H. Sugita, J. Suzuki, O. Tajima, S. Takada, R. Takaku, S. Takakura, S. Takatori, D. Tanabe, E. Taylor, K. L. Thompson, B. Thorne, T. Tomaru, T. Tomida, N. Tomita, M. Tristram, C. Tucker, P. Turin, M. Tsujimoto, S. Uozumi, S. Utsunomiya, Y. Uzawa, F. Vansyngel, I. K. Wehus, B. Westbrook, M. Willer, N. Whitehorn, Y. Yamada, R. Yamamoto, N. Yamasaki, T. Yamashita, M. Yoshida, Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique (LERMA (UMR_8112)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Cergy Pontoise (UCP), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Service des Basses Températures (SBT ), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire des Cryoréfrigérateurs et Cryogénie Spatiale (LCCS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)
Subjects: Cosmic microwave background, FOS: Physical sciences, cosmic background radiation: polarization, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, Radio spectrum, law.invention, Antenna array, Telescope, Optics, bolometer, Settore FIS/05 - Astronomia e Astrofisica, law, Polarization, 0103 physical sciences, B-mode, Inflation, Satellite, General Materials Science, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Instrumentation and Methods for Astrophysics (astro-ph.IM), 010303 astronomy & astrophysics, activity report, detector: design, Physics, 010308 nuclear & particles physics, business.industry, Gravitational wave, Detector, Bolometer, Astrophysics::Instrumentation and Methods for Astrophysics, Condensed Matter Physics, Astrophysics - Astrophysics of Galaxies, Atomic and Molecular Physics, and Optics, cryogenics, Astrophysics of Galaxies (astro-ph.GA), electronics: readout, interference: quantum, Transition edge sensor, Astrophysics - Instrumentation and Methods for Astrophysics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], business, cosmic background radiation: anisotropy
Abstract: 著者人数: 153名（所属. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS): 堂谷, 忠靖; 羽澄, 昌史; 今田, 大皓; 満田, 和久; 坂井, 真一郎; Tomida, T.; 辻本, 匡弘; Yamamoto, R.; 山崎, 典子）, Accepted: 2018-04-30, 資料番号: SA1180210000
Published: 2018
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13. Concept Study of Optical Configurations for High-Frequency Telescope for LiteBIRD

Author: D. W. Curtis, M. Nakajima, T. Funaki, R. Takaku, Yoshinori Uzawa, Carlo Baccigalupi, Johannes Hubmayr, U. Fuskeland, Theodore Kisner, S. Beckman, Anna Mangilli, Erminia Calabrese, Neil Goeckner-Wald, Uroš Seljak, M. Nagai, N. Katayama, Jonathan Aumont, Carole Tucker, Suguru Takada, Shin Utsunomiya, Kazunori Kohri, R. Nagata, Kam Arnold, M. Bucher, A. Dominjon, N. Sato, M. A. Dobbs, Shin-ichiro Sakai, Darcy Barron, Gene C. Hilton, H. K. Eriksen, Yasuhiro Yamada, Oliver Jeong, Aritoki Suzuki, Atsushi Okamoto, Tadayasu Dotani, T. Tomida, D. Meilhan, L. Duband, S. A. Kernasovskiy, S. Takakura, S. Takatori, R. Stompor, A. Ducout, B. Thorne, Eiichiro Komatsu, Hajime Sugai, Keisuke Shinozaki, N. Tomita, J. Fischer, Yuji Chinone, C. L. Kuo, L. Montier, Akito Kusaka, Toshiaki Iida, Aaron Lee, Yuki Inoue, Makoto Sawada, Ingunn Kathrine Wehus, L. Hayes, Mitsuhiro Yoshida, K. L. Thompson, H. Nishino, Mathieu Remazeilles, Tomotake Matsumura, Shugo Oguri, K. Komatsu, Reijo Keskitalo, T. Yamashita, T. Kawasaki, Takahiro Okamura, Masashi Hazumi, Osamu Tajima, Takayuki Tomaru, G. Patanchon, M. Tristram, Giampaolo Pisano, Hirokazu Ishino, Masato Naruse, Jun-ichi Suzuki, H. M. Cho, Paul Turin, Toshiya Namikawa, Yuki Sakurai, Y. Kida, Blake D. Sherwin, J. Grain, Chiko Otani, Noriko Y. Yamasaki, N. W. Halverson, Shuji Matsuura, S. Uozumi, Takashi Noguchi, T. Nagasaki, H. Imada, M. Willer, Y. Sato, M. Inoue, J. M. Duval, Bruno Maffei, Toshifumi Shimizu, Yuto Minami, F. Boulanger, Tucker Elleflot, Charles A. Hill, Benjamin Westbrook, Shogo Nakamura, Peter A. R. Ade, Kaori Hattori, Paul L. Richards, Alex Lazarian, Y. Segawa, Julian Borrill, Ryo Yamamoto, Kiyotomo Ichiki, M. Maki, Satoru Mima, D. Tanabe, Jo Dunkley, Kazuhisa Mitsuda, Soumen Basak, Gabriel M. Rebeiz, Tom Nitta, T. de Haan, T. Hamada, H. Kanai, K. Ganga, Hideo Ogawa, D. Kaneko, A. Cukierman, Nathan Whitehorn, Eric V. Linder, Masaya Hasegawa, Josquin Errard, Kimihiro Kimura, Hiroyuki Sugita, David Alonso, T. Hasebe, Kent D. Irwin, E. Taylor, Norio Okada, N. Hidehira, Shingo Kashima, A. Kibayashi, Noah Kurinsky, T. Fujino, Y. Akiba, Makoto Hattori, Dale Li, Masahiro Tsujimoto, Yutaro Sekimoto, F. Vansyngel, Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Electronique et des Technologies de l'Information (CEA-LETI), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Service des Basses Températures (SBT ), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Laboratoire des Cryoréfrigérateurs et Cryogénie Spatiale (LCCS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), and Université Grenoble Alpes (UGA)-Direction de Recherche Technologique (CEA) (DRT (CEA))
Subjects: Cosmic microwave background radiation, Inflation, Satellite, Telescope, Silicon, Cosmic microwave background, chemistry.chemical_element, engineering.material, 01 natural sciences, law.invention, 010309 optics, Optics, Settore FIS/05 - Astronomia e Astrofisica, Coating, law, 0103 physical sciences, General Materials Science, Sensitivity (control systems), [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, Physics, business.industry, Condensed Matter Physics, Atomic and Molecular Physics, and Optics, Lens (optics), chemistry, engineering, Reflection (physics), business, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: 著者人数: 152名（所属. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS): 長谷部, 孝; 堂谷, 忠靖; 羽澄, 昌史; 今田, 大皓; 満田, 和久; 坂井, 真一郎; 関本, 裕太郎; Tomida, T.; 辻本, 匡弘; Yamamoto, R.; 山崎, 典子), Accepted: 2018-04-07, 資料番号: SA1180209000
Published: 2017
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14. Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy

Author: S. Richardson, E. Kimber, H. Kim, Diana Castro, H. Johnson, A. C. Tesi Rocha, Matthias Eckenweiler, C. Manzitti, John W. Day, R. De Sanctis, M. Gormley, Mar Tulinius, Mirac Yildirim, C. M. Temucin, M. Gratacos Vinola, S. Matsumaru, F. Weber-Guzman, J. Kitsuwa-Lowe, Lavinia Fanelli, T. Sato, W. C. Virginia, J. H. Hsu, S. Nagata, A. Michoulas, Sally Dunaway, Mariacristina Scoto, R. Shell, R. Laine, D. DiBella, C. King, Jacqueline Montes, Haluk Topaloglu, Maryam Oskoui, Didem Ardicli, K. Rupprich, C. Stella, F. Dorban, Alan C Farrow-Gillespie, S. A. Choi, T. Ikai, W. C. Liang, N. Matsushima, PH Lister, Arnaud Vanlander, N. Rausch, T. T. Duong, Marika Pane, Melissa Gibbons, M. M. Homi, A. K. Kroksmark, B. Andres, Kristin J. Krosschell, S. Patnaik, L. Welsh, Eduardo F. Tizzano, M. Gallardo, Michèle Mayer, Sarada Sakamuri, W. Liew, T. Spain, M. Yang, Kayoko Saito, Edward C. Smith, L. Sanabria, Astrid Pechmann, H. Kaneko, Leslie Nelson, Basil T. Darras, C. Milleson, Janbernd Kirschner, R. Arakawa, Margot Morrison, Y. Kaburagi, P. Dinunzio, C. K.W. Joseph, M. Chadehumbe, Craig M. Zaidman, S. Nicolarsen, Hyung Ik Shin, Alberto Garaventa, James J. Dowling, J. S. Lee, K. Booker, A. Takeshita, D. McElroy, K. Carroll, D. Vens, Y. Chiba, L. Wand, C. Kelly, Luke Smith, H. Shimomura, M. Srour, J. B. Bodensteriner, B. Rippberger, A. Herbert, Eugenio Mercuri, H. Jo, J. Turner, A. Camuto, N. Parziale, J. O'Brien, N. Nelson, E. Serdaroglu, Jong-Hee Chae, V. Tahon, E. Toro Tamargo, L. Weimer, T. Voit, L. W.M. Wendy, J. Rambaud, G. Gilbert, C. Zimmerman, S. Kramer, D. McFall, Jennifer Perez, N. Berthon-Jones, Jessica Taytard, Marco Luigetti, J. Pisco Domingos, R. Van Der Looven, Genevieve D'Souza, C. Berde, E. Roland, M. de Los Angeles Tormos Munoz, J. Zigmont, S. Baily, S. Gilabert, H. Nakatsukasa, S. Trest, Bahadır Konuşkan, H. A. Ferreira Sampaio, Z. John Zhong, G. VanderVeen, V. Allen, C. Aguilar, N. Taniguchi, G. Ordonez, Elizabeth Kichula, F. Shu, M. N. Chui-San, M. Zinn, Anne M. Connolly, Ian R. Woodcock, Ayşe Karaduman, R. Haldenby, K. Hirasawa, F. Munell Casadesus, L.D.M. Peña, Vamshi K. Rao, Allan M. Glanzman, Claudia A. Chiriboga, A. Martinez Bermejo, John F. Brandsema, S. Epinosa Garcia, M. K. Schroth, T. Shibano, Richard Gee, Valeria Ricotti, Y. Ito, Y. Tanaka, S. Arpin, C. S. Yan, L. Schottlaender, Marco Piastra, M. Kauk, Francesco Muntoni, K. Sugimoto, Öznur Yilmaz, K. DeCock, Kathryn Selby, T. Yanagishita, Concetta Palermo, H. W. Chung, B. Taicher, Jiri Vajsar, K. Zilke, R. Gadeken, A. Yamauchi, Marta Bertoli, Nancy L. Kuntz, T. Tachikawa, C. Johnson, A. Mayhew, Jahannaz Dastgir, Y. J. Jong, P. C. Chou, G. Rivera, T. N. Shun, Y. H. Ju, N. Holuba La Marca, M. Toms, Matthew Civitello, Eugene Schneider, C. Lilien, S. Ito, C. Skura, Y. Yvonne, K. O'Reardon, Barry S. Russman, Janet Quigley, J. W. Said, B. Planas Pascual, R. J. Ramamurthi, Wildon Farwell, V. Selby, W. Y. Connie, M. Souris, Nicholas E. Johnson, M. Miki, N. Sponemann, Andrei Constantinescu, K. Mayne, H. H. Shih, B. Sanjanwala, Teresa Gidaro, D. Berry, Gihan Tennekoon, A. G. Le Moing, Danielle Ramsey, C. Poulin, S. Goldman, K. Watson, H. L. Teoh, N. J. Palacios, Tai-Heng Chen, A. C. Chung, Terri Carry, J. Coates, D. Zielinski, R. Vialle, F. G. Yildiz Sarikaya, Marcus Krüger, M. del Mar Garcia Romero, E. Michael, E. D. Austin, J. Janas, K. Engelstad, S. Y. Kim, M. Alavarez Molinero, Leon G. Epstein, Monique M. Ryan, Jean Flickinger, D. Benjamin, S. Wider, C. S. Davis, Jena M. Krueger, I. J.K. Janice, Darryl C. De Vivo, M. del Mar Melendez Plumed, Y. Takeshima, C. Gunbey, Serena Sivo, A. Christiaens, Q. Ollievier, Elizabeth Mirek, D. Stanford, Susan T. Iannaccone, Jonathan E. Kurz, D. Cook, C. S. Ng, A. Koka, V. Chau, M. del Pilar Tirado Requero, M. B. Gomez Garcia de la Banda, E. M. Yiu, Amy Pasternak, Rosangel Cruz, S. So, S. I. Pascual Pascual, V. G. Haliloglu, E. S. Schroers, P. Jachertz, C. Ortiz-Miller, Sandra Coppens, J. Lee, M. Popolizio, Michael Doumit, Rachel Salazar, Michelle A. Farrar, Peter G. Fuhr, M. Pedermonte, L. S. Lord-Halvorson, W. Leon, Y. S. Zeng, L. D'Argenzio, Russell J. Butterfield, C. Blomgren, Erika Finanger, S. Shea, Paola Tacchetti, N. Y. Ki, H. W. Choi, K. Oriyama, S. Wittevrongel, Catherine Siener, K. Mizuochi, M. Cowie, R. Van Coster, E. Gargaun, S. M. Scuplak, Sibylle Vogt, S. Stein, Tim Harrington, P. M. Ingelmo, J. Wootton, M. Tanyildiz, A. F. Rucian, Jonathan Marra, C. Frank Bennett, Claire L Wood, Nicolas Deconinck, Adnan Y. Manzur, Helene Verhelst, B. Purse, P. L. Léger, J. Cappell, S. Aziz-Zaman, H. Y. Wang, Claudio Bruno, S. Garcia Guixot, Robert Muni Lofra, Federica Trucco, S. M. Chun, Catherine E. Roberts, Ulrike Schara, Walter G. Bradley, K. L. De Valle, E. De Vos voor, S. Borell, A. Lim, Sophelia H. S. Chan, L. Rao, M. Shichiji, S. Rooze, T. M. Newcomb, Fouad Al-Ghamdi, Chiara Fiorillo, J. D. Endsley, L. Y. Sigurdardottir, Pallavi Anand, A. Zuffi, Julie A. Parsons, M. Kasper, A. Nishikawa, Sarah Gheuens, S. Turgeon-Desilet, T. Fujino, L. Staudt, Y. C. Wu, Jacinda B. Sampson, Paola Lanteri, Stephanie DeArmey, Partha S. Ghosh, Alexandra C. Ross, L. Adang, Laurent Servais, V. Tran, Alan Bielsky, Y. Otani, Navil F. Sethna, J. Hen, Perry B. Shieh, N. Fukuda, N. Miller, K. Eto, S. Paulose, Niklas Darin, C. Sabapathy, Robert J. Graham, Christopher Proud, Richard S. Finkel, Alexander G. Khandji, A. Della Marina, Adrian Murphy, Kathie M. Bishop, Tejaswi Kandula, Valentina Lanzillotta, Heather Szelag, Kalliopi Sofou, Y. H. Chou, Heike Koelbel, J. Eldblom, T. Lee, M. M. Martinez Moreno, Volker Straub, Laura E. Case, A. Lindstedt, G. Gili, A. Frank, H. C.C. Alvin, A. Ganfuss, Karen Herbert, Paul T. Golumbek, D. Villano, B. Wenderickx, B. C. Lim, W. S. Son, Schara, Ulrike (Beitragende*r), Ganfuss, Andrea (Beitragende*r), Koelbel, Heike (Beitragende*r), Rupprich, Katrin (Beitragende*r), Schroers, Ester Sarah (Beitragende*r), Sponemann, Nina (Beitragende*r), and Çocuk Sağlığı ve Hastalıkları
Subjects: Male, 0301 basic medicine, Pathology, Movement disorders, animal diseases, Messenger, Oligonucleotides, Medizin, Spinal Muscular Atrophies of Childhood, 0302 clinical medicine, Age of Onset, Disease-Free Survival, Double-Blind Method, Female, Humans, Infant, Injections, Spinal, Motor Skills, Oligonucleotides, Antisense, RNA, Messenger, Respiration, Artificial, Survival Analysis, Survival of Motor Neuron 2 Protein, Medicine (all), Respiration, General Medicine, Settore MED/26 - NEUROLOGIA, medicine.anatomical_structure, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Artificial, Nusinersen, medicine.symptom, medicine.medical_specialty, Spinal, Injections, 03 medical and health sciences, Atrophy, General & Internal Medicine, Settore MED/41 - ANESTESIOLOGIA, medicine, Antisense, Survival analysis, business.industry, Spinal muscular atrophy, Motor neuron, medicine.disease, nervous system diseases, 030104 developmental biology, nervous system, RNA, Infantile onset, Age of onset, business, 030217 neurology & neurosurgery
Abstract: Background: Spinal muscular atrophy is an autosomal recessive neuromuscular disorder that is caused by an insufficient level of survival motor neuron (SMN) protein. Nusinersen is an antisense oligonucleotide drug that modifies pre–messenger RNA splicing of the SMN2 gene and thus promotes increased production of full-length SMN protein. Methods: We conducted a randomized, double-blind, sham-controlled, phase 3 efficacy and safety trial of nusinersen in infants with spinal muscular atrophy. The primary end points were a motor-milestone response (defined according to results on the Hammersmith Infant Neurological Examination) and event-free survival (time to death or the use of permanent assisted ventilation). Secondary end points included overall survival and subgroup analyses of event-free survival according to disease duration at screening. Only the first primary end point was tested in a prespecified interim analysis. To control the overall type I error rate at 0.05, a hierarchical testing strategy was used for the second primary end point and the secondary end points in the final analysis. Results: In the interim analysis, a significantly higher percentage of infants in the nusinersen group than in the control group had a motor-milestone response (21 of 51 infants [41%] vs. 0 of 27 [0%], P Conclusions: Among infants with spinal muscular atrophy, those who received nusinersen were more likely to be alive and have improvements in motor function than those in the control group. Early treatment may be necessary to maximize the benefit of the drug.
Published: 2017

15. The Simons Array CMB polarization experiment

Author: N. Stebor, P. Ade, Y. Akiba, C. Aleman, K. Arnold, C. Baccigalupi, B. Barch, D. Barron, S. Beckman, A. Bender, D. Boettger, J. Borrill, S. Chapman, Y. Chinone, A. Cukierman, T. de Haan, M. Dobbs, A. Ducout, R. Dunner, T. Elleflot, J. Errard, G. Fabbian, S. Feeney, C. Feng, T. Fujino, G. Fuller, A. J. Gilbert, N. Goeckner-Wald, J. Groh, G. Hall, N. Halverson, T. Hamada, M. Hasegawa, K. Hattori, M. Hazumi, C. Hill, W. L. Holzapfel, Y. Hori, L. Howe, Y. Inoue, F. Irie, G. Jaehnig, A. Jaffe, O. Jeong, N. Katayama, J. P. Kaufman, K. Kazemzadeh, B. G. Keating, Z. Kermish, R. Keskitalo, T. Kisner, A. Kusaka, M. Le Jeune, A. T. Lee, D. Leon, E. V. Linder, L. Lowry, F. Matsuda, T. Matsumura, N. Miller, J. Montgomery, M. Navaroli, H. Nishino, H. Paar, J. Peloton, D. Poletti, G. Puglisi, C. R. Raum, G. M. Rebeiz, C. L. Reichardt, P. L. Richards, C. Ross, K. M. Rotermund, Y. Segawa, B. D. Sherwin, I. Shirley, P. Siritanasak, L. Steinmetz, R. Stompor, A. Suzuki, O. Tajima, S. Takada, S. Takatori, G. P. Teply, A. Tikhomirov, T. Tomaru, B. Westbrook, N. Whitehorn, A. Zahn, O. Zahn, Institut Lagrange de Paris, Sorbonne Universités, AstroParticule et Cosmologie (APC (UMR_7164)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Sorbonne Université (SU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Stebor, N, Ade, P, Akiba, Y, Aleman, C, Arnold, K, Baccigalupi, C, Barch, B, Barron, D, Beckman, S, Bender, A, Boettger, D, Borrill, J, Chapman, S, Chinone, Y, Cukierman, A, De Haan, T, Dobbs, M, Ducout, A, Dunner, R, Elleflot, T, Errard, J, Fabbian, G, Feeney, S, Feng, C, Fujino, T, Fuller, G, Gilbert, A, Goeckner-Wald, N, Groh, J, Hall, G, Halverson, N, Hamada, T, Hasegawa, M, Hattori, K, Hazumi, M, Hill, C, Holzapfel, W, Hori, Y, Howe, L, Inoue, Y, Irie, F, Jaehnig, G, Jaffe, A, Jeong, O, Katayama, N, Kaufman, J, Kazemzadeh, K, Keating, B, Kermish, Z, Keskitalo, R, Kisner, T, Kusaka, A, Le Jeune, M, Lee, A, Leon, D, Linder, E, Lowry, L, Matsuda, F, Matsumura, T, Miller, N, Montgomery, J, Navaroli, M, Nishino, H, Paar, H, Peloton, J, Poletti, D, Puglisi, G, Raum, C, Rebeiz, G, Reichardt, C, Richards, P, Ross, C, Rotermund, K, Segawa, Y, Sherwin, B, Shirley, I, Siritanasak, P, Steinmetz, L, Stompor, R, Suzuki, A, Tajima, O, Takada, S, Takatori, S, Teply, G, Tikhomirov, A, Tomaru, T, Westbrook, B, Whitehorn, N, Zahn, A, Zahn, O, Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Holland, Wayne S, Zmuidzinas, Jonas, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)
Subjects: Gark energy, Cosmic microwave background, Observatories, cosmic background radiation: polarization, 01 natural sciences, Receivers, Multiplexing, law.invention, Cosmic microwave background radiation, law, Observatory, Polarization, Superconductors, dark energy, Physics, Settore FIS/05, precision measurement, superconductivity, polarimeters, Astrophysics::Instrumentation and Methods for Astrophysics, neutrinos, Polarization (waves), Bolometers, cryogenics, amplifier, interference: quantum, Dark matter, gravitational lensing, Gravitational lensing, Astrophysics::Cosmology and Extragalactic Astrophysics, dark matter, cosmic background radiation: B-mode, Settore FIS/05 - Astronomia e Astrofisica, bolometer, 0103 physical sciences, Neutrino, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], inflation, 010306 general physics, detector: design, activity report, cosmic microwave background radiation, polarization, 010308 nuclear & particles physics, Gravitational wave, Sensors, Bolometer, Astronomy, Polarimeter, Inflation, Amplifiers, Gravitational lens, Antennas, Transition edge sensor, Telescopes
Abstract: International audience; The Simons Array is a next generation cosmic microwave background (CMB) polarization experiment whose science target is a precision measurement of the B-mode polarization pattern produced both by inflation and by gravitational lensing. As a continuation and extension of the successful POLARBEAR experimental program, the Simons Array will consist of three cryogenic receivers each featuring multichroic bolometer arrays mounted onto separate 3.5m telescopes. The first of these, also called POLARBEAR-2A, will be the first to deploy in late 2016 and has a large diameter focal plane consisting of dual-polarization dichroic pixels sensitive at 95 GHz and 150 GHz. The POLARBEAR-2A focal plane will utilize 7,588 antenna-coupled superconducting transition edge sensor (TES) bolometers read out with SQUID amplifiers using frequency domain multiplexing techniques. The next two receivers that will make up the Simons Array will be nearly identical in overall design but will feature extended frequency capability. The combination of high sensitivity, multichroic frequency coverage and large sky area available from our mid-latitude Chilean observatory will allow Simons Array to produce high quality polarization sky maps over a wide range of angular scales and to separate out the CMB B-modes from other astrophysical sources with high fidelity. After accounting for galactic foreground separation, the Simons Array will detect the primordial gravitational wave B-mode signal to r > 0.01 with a significance of > 5σ and will constrain the sum of neutrino masses to 40 meV (1σ) when cross-correlated with galaxy surveys. We present the current status of this funded experiment, its future, and discuss its projected science return.© (2016) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Published: 2016
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16. The POLARBEAR-2 and the Simons Array Experiment

Author: Peter A. R. Ade, O. Zahn, Gabriel M. Rebeiz, Suguru Takada, Josquin Errard, D. Poletti, Zigmund Kermish, K. Mizukami, Carlo Baccigalupi, Darcy Barron, Neil Goeckner-Wald, Theodore Kisner, Christopher Raum, G. Hall, R. Dunner, Joshua Montgomery, Tucker Elleflot, Paul L. Richards, A. J. Gilbert, Stephen M. Feeney, M. Navaroli, T. Fujino, Nathan Stebor, Aritoki Suzuki, S. Takatori, D. Boettger, M. A. Dobbs, J. Kaufman, T. Yamashita, Eric V. Linder, Giulio Fabbian, Y. Akiba, Adrian T. Lee, A. Tikhomirov, B. Westbrook, Tomotake Matsumura, Jose H. Groh, Amy N. Bender, Masaya Hasegawa, Scott Chapman, Brian Keating, Colin Ross, Nathan J. Miller, Y. Hori, Radek Stompor, L. Howe, Reijo Keskitalo, A. Ducout, H. Nishino, A. Cukierman, G. Jaehnig, Takayuki Tomaru, I. Shirley, K. M. Rotermund, Osamu Tajima, Masashi Hazumi, D. Leon, Christian L. Reichardt, Kam Arnold, Blake D. Sherwin, Praween Siritanasak, J. Peloton, Kaori Hattori, T. Hamada, L. Lowry, M. Le Jeune, C. Aleman, Giuseppe Puglisi, Jun-ichi Suzuki, F. Irie, Akito Kusaka, W. Holzapfel, O. B. Jeong, Julian Borrill, Chang Feng, A. Zahn, Yuji Chinone, Nobuhiko Katayama, N. Whitehorn, Y. Segawa, K. Kazemzadeh, S. Takakura, Andrew H. Jaffe, N. W. Halverson, T. de Haan, Yuki Inoue, Frederick Matsuda, C. Hill, G. Fuller, Université Paris-Sorbonne (UP4), AstroParticule et Cosmologie (APC (UMR_7164)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), POLARBEAR, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Suzuki, A, Ade, P, Akiba, Y, Aleman, C, Arnold, K, Baccigalupi, C, Barch, B, Barron, D, Bender, A, Boettger, D, Borrill, J, Chapman, S, Chinone, Y, Cukierman, A, Dobbs, M, Ducout, A, Dunner, R, Elleflot, T, Errard, J, Fabbian, G, Feeney, S, Feng, C, Fujino, T, Fuller, G, Gilbert, A, Goeckner-Wald, N, Groh, J, Haan, T, Hall, G, Halverson, N, Hamada, T, Hasegawa, M, Hattori, K, Hazumi, M, Hill, C, Holzapfel, W, Hori, Y, Howe, L, Inoue, Y, Irie, F, Jaehnig, G, Jaffe, A, Jeong, O, Katayama, N, Kaufman, J, Kazemzadeh, K, Keating, B, Kermish, Z, Keskitalo, R, Kisner, T, Kusaka, A, Jeune, M, Lee, A, Leon, D, Linder, E, Lowry, L, Matsuda, F, Matsumura, T, Miller, N, Mizukami, K, Montgomery, J, Navaroli, M, Nishino, H, Peloton, J, Poletti, D, Puglisi, G, Rebeiz, G, Raum, C, Reichardt, C, Richards, P, Ross, C, Rotermund, K, Segawa, Y, Sherwin, B, Shirley, I, Siritanasak, P, Stebor, N, Stompor, R, Suzuki, J, Tajima, O, Takada, S, Takakura, S, Takatori, S, Tikhomirov, A, Tomaru, T, Westbrook, B, Whitehorn, N, Yamashita, T, Zahn, A, Zahn, O, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université Paris-Sorbonne ( UP4 ), AstroParticule et Cosmologie ( APC - UMR 7164 ), and Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA )
Subjects: Cosmic microwave background, Inflation, Gravitational weak lensing, Polarization, B-mode, [ PHYS.ASTR ] Physics [physics]/Astrophysics [astro-ph], cosmic background radiation, 7. Clean energy, 01 natural sciences, pixel, optical, General Materials Science, neutrino: mass, [ PHYS.PHYS.PHYS-INS-DET ] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Weak gravitational lensing, Mathematical Physics, Physics, Settore FIS/05, Astrophysics::Instrumentation and Methods for Astrophysics, Polarization (waves), Condensed Matter Physics, Atomic and Molecular Physics, and Optics, astro-ph.CO, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics, General Physics, noise, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Frequency band, Classical Physics, Cosmic background radiation, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, Noise-equivalent temperature, Optics, Settore FIS/05 - Astronomia e Astrofisica, gravitation: lens, bolometer, 0103 physical sciences, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, Instrumentation and Methods for Astrophysics (astro-ph.IM), 010308 nuclear & particles physics, business.industry, Gravitational wave, gravitational radiation, temperature, sensitivity, Transition edge sensor, business, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], astro-ph.IM
Abstract: We present an overview of the design and status of the \Pb-2 and the Simons Array experiments. \Pb-2 is a Cosmic Microwave Background polarimetry experiment which aims to characterize the arc-minute angular scale B-mode signal from weak gravitational lensing and search for the degree angular scale B-mode signal from inflationary gravitational waves. The receiver has a 365~mm diameter focal plane cooled to 270~milli-Kelvin. The focal plane is filled with 7,588 dichroic lenslet-antenna coupled polarization sensitive Transition Edge Sensor (TES) bolometric pixels that are sensitive to 95~GHz and 150~GHz bands simultaneously. The TES bolometers are read-out by SQUIDs with 40 channel frequency domain multiplexing. Refractive optical elements are made with high purity alumina to achieve high optical throughput. The receiver is designed to achieve noise equivalent temperature of 5.8~$\mu$K$_{CMB}\sqrt{s}$ in each frequency band. \Pb-2 will deploy in 2016 in the Atacama desert in Chile. The Simons Array is a project to further increase sensitivity by deploying three \Pb-2 type receivers. The Simons Array will cover 95~GHz, 150~GHz and 220~GHz frequency bands for foreground control. The Simons Array will be able to constrain tensor-to-scalar ratio and sum of neutrino masses to $\sigma(r) = 6\times 10^{-3}$ at $r = 0.1$ and $\sum m_\nu (\sigma =1)$ to 40 meV., Comment: Accepted to Journal of Low Temperature Physics LTD16 Special Issue, Low Temperature Detector 16 Conference Proceedings, 5 pages, 1 figure
Published: 2015
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17. Inhibition of microbial growth by ajoene, a sulfur-containing compound derived from garlic

Author: R Naganawa, K Ishikawa, N Iwata, T Fujino, A Suzuki, and H Fukuda
Subjects: Gram-positive bacteria, Bacillus cereus, Biology, Gram-Positive Bacteria, Applied Microbiology and Biotechnology, Microbiology, Minimum inhibitory concentration, chemistry.chemical_compound, Anti-Infective Agents, Yeasts, Gram-Negative Bacteria, Ajoene, Cysteine, Disulfides, Garlic, Antibacterial agent, Plants, Medicinal, Ecology, Plant Extracts, Drug Resistance, Microbial, Antimicrobial, biology.organism_classification, Anti-Bacterial Agents, chemistry, Sulfoxides, Platelet aggregation inhibitor, Lactobacillus plantarum, Platelet Aggregation Inhibitors, Food Science, Biotechnology, Research Article
Abstract: Ajoene, a garlic-derived sulfur-containing compound that prevents platelet aggregation, exhibited broad-spectrum antimicrobial activity. Growth of gram-positive bacteria, such as Bacillus cereus, Bacillus subtilis, Mycobacterium smegmatis, and Streptomyces griseus, was inhibited at 5 micrograms of ajoene per ml. Staphylococcus aureus and Lactobacillus plantarum also were inhibited below 20 micrograms of ajoene per ml. For gram-negative bacteria, such as Escherichia coli, Klebsiella pneumoniae, and Xanthomonas maltophilia, MICs were between 100 and 160 micrograms/ml. Ajoene also inhibited yeast growth at concentrations below 20 micrograms/ml. The microbicidal effect of ajoene on growing cells was observed at slightly higher concentrations than the corresponding MICs. B. cereus and Saccharomyces cerevisiae were killed at 30 micrograms of ajoene per ml after 24 h of cultivation when cultivation was started at 10(5) cells per ml. However, the minimal microbicidal concentrations for resting cells were at 10 to 100 times higher concentrations than the corresponding MICs. The disulfide bond in ajoene appears to be necessary for the antimicrobial activity of ajoene, since reduction by cysteine, which reacts with disulfide bonds, abolished its antimicrobial activity.
Published: 1996

18. Development of TESLA-type cavity at KEK

Author: T. Suzuki, H. Umezawa, M. Ono, Masayoshi Wake, T. Fujino, Shuichi Noguchi, Eiji Kako, Toshio Shishido, Kenji Saito, T. Higuchi, M. Matsuoka, Y. Funahashi, and Hitoshi Inoue
Subjects: Physics, Engineering, chemistry, Condensed matter physics, Superconducting cavity, Niobium, chemistry.chemical_element, Development (differential geometry), High field, Engineering physics
Abstract: The development of superconducting cavity for high accelerating fields has been continued at KEK on the basis developed for TRISTAN superconducting cavity. Many attempts have been pursued to achieve high field and to understand the phenomena that limit the cavity performance at high field; investigations of niobium material, surface treatment, heat treatment, surface condition, cavity-shape and cavity-forming. Accelerating fields of more than 25 MV/m have been achieved repeatedly in the several single-cell cavities, even though we do not yet fully understand what happens at high fields. The present status will be reported.
Published: 1996

19. Relation between QT and RR intervals in patients with bradyarrhythmias

Author: Naohiko Takahashi, Mikiko Nakagawa, T. Saikawa, Shuji Ishida, Morio Ito, and T. Fujino
Subjects: Adult, Male, Adolescent, Heart block, RR interval, QT interval, Sick sinus syndrome, Linear regression, medicine, Humans, Aged, Sick Sinus Syndrome, medicine.diagnostic_test, business.industry, Arrhythmias, Cardiac, Middle Aged, medicine.disease, Heart Block, Anesthesia, Ambulatory, Electrocardiography, Ambulatory, Female, Cardiology and Cardiovascular Medicine, business, Atrioventricular block, Electrocardiography, Research Article
Abstract: OBJECTIVE--To investigate the relation between QT and RR intervals in the sick sinus syndrome or high degree atrioventricular block. PATIENTS--32 patients with episodes of prolonged RR intervals (> or = 2.6 s) on Holter electrocardiographic recordings. DESIGN--QT and RR intervals were measured manually every 100 to 150 beats on electrocardiographic strips reprinted from the Holter tape over 24 hours. The slope of the QT/RR relation was determined by the linear regression equation for RR intervals < or = 1.4 s (slope 1) and > 1.4 s (slope 2). RESULTS--Slope 2 (0.0068 (0.0030)) was significantly lower than slope 1 (0.0824 (0.0059), P < 0.0001) in the overall patient population. Slopes 1 and 2 were significantly lower (P < 0.001) in the 23 patients with QT intervals at the preceding RR interval of 1 s (QT1s) of < 0.44 s (0.0692 (0.0053) and 0.0019 (0.0030), respectively) than in the nine patients with QT1s intervals > or = 0.44 s (0.1159 (0.0091) and 0.0194 (0.0055), respectively). Slopes 1 and 2 correlated positively with QT1s interval in all patients. CONCLUSIONS--The QT/RR relation was comparatively flat when the RR interval was prolonged. Patients with prolonged QT intervals showed exaggerated prolongation of the QT interval with prolonged cycle lengths when compared with patients with normal QT intervals.
Published: 1995

20. Slow accommodation release with a cerebellar lesion

Author: Motohiro Kiyosawa, T. Fujino, Takashi Tokoro, and Tsutomu Kawasaki
Subjects: Adult, Cerebellum, medicine.medical_specialty, Visual acuity, Eye disease, Visual Acuity, Vision disorder, Cellular and Molecular Neuroscience, Text mining, Cerebellar Diseases, Ophthalmology, medicine, Humans, Cyst, Postoperative Period, business.industry, Accommodation, Ocular, medicine.disease, Sensory Systems, Arachnoid Cysts, medicine.anatomical_structure, Etiology, Female, medicine.symptom, business, Accommodation, Research Article
Published: 1993

21. A gene for a Class II DNA photolyase from Oryza sativa: cloning of the cDNA by dilution-amplification.

Author: T. Hirouchi, S. Nakajima, T. Najrana, M. Tanaka, T. Matsunaga, J. Hidema, M. Teranishi, T. Fujino, T. Kumagai, and K. Yamamoto
Subjects: ULTRAVIOLET radiation, DNA, ENZYMES, ARABIDOPSIS thaliana, GENES
Abstract: Ultraviolet radiation induces the formation of two classes of photoproducts in DNA?the cyclobutane pyrimidine dimer (CPD) and the pyrimidine [6-4] pyrimidone photoproduct (6-4 product). Many organisms produce enzymes, termed photolyases, which specifically bind to these lesions and split them via a UV-A/blue light-dependent mechanism, thereby reversing the damage. These photolyases are specific for either CPDs or 6-4 products. Two classes of photolyases (class I and class II) repair CPDs. A gene that encodes a protein with class II CPD photolyase activity in vitro has been cloned from several plants including Arabidopsis thaliana, Cucumis sativus and Chlamydomonas reinhardtii. We report here the isolation of a homolog of this gene from rice ( Oryza sativa), which was cloned on the basis of sequence similarity and PCR-based dilution-amplification. The cDNA comprises a very GC-rich (75%) 5' region, while the 3' portion has a GC content of 50%. This gene encodes a protein with CPD photolyase activity when expressed in E. coli. The CPD photolyase gene encodes at least two types of mRNA, formed by alternative splicing of exon 5. One of the mRNAs encodes an ORF for 506 amino acid residues, while the other is predicted to code for 364 amino acid residues. The two RNAs occur in about equal amounts in O. sativa cells. [ABSTRACT FROM AUTHOR]
Published: 2003

22. Tegumentary papillae of Echinostoma caproni cercariae (Trematoda: Echinostomatidae).

Author: T. Nakano, T. Fujino, H. Washioka, A. Tonosaki, K. Goto, and B. Fried
Subjects: SCANNING electron microscopy, STAINS & staining (Microscopy), CERCARIAE
Abstract: Abstract. Argentophilic staining and scanning electron microscopy were used to study the tegumentary papillae of Echinostoma caproni cercariae. The most abundant tegumentary papillae were uniciliate, but multiciliate papillae were also found, mainly on the ventral aspect of the oral collar. The distribution pattern of the papillae on the body and tail was in general similar to that seen in the cercariae of other 37-collar-spined Echinostoma species. Some differences were noted between E. caproni and the allopatric species, E. trivolvis. E. caproni has a greater number of papillae associated with the collar spines than does E. trivolvis. E. caproni has uniciliate papillae on the acetabulum, whereas E. trivolvis does not. Chaetotaxy is useful to distinguish subtle morphological differences in cercarial species in the 37-collar-spined Echinostoma complex. [ABSTRACT FROM AUTHOR]
Published: 2003

23. Measurement of the Cosmic Microwave Background Polarization Lensing Power Spectrum from Two Years of POLARBEAR Data.

Author: M. Aguilar Faúndez, K. Arnold, C. Baccigalupi, D. Barron, D. Beck, S. Beckman, F. Bianchini, J. Carron, K. Cheung, Y. Chinone, H. El Bouhargani, T. Elleflot, J. Errard, G. Fabbian, C. Feng, T. Fujino, N. Goeckner-Wald, T. Hamada, M. Hasegawa, and M. Hazumi
Subjects: POWER spectra, COSMIC background radiation, MICROWAVE measurements, DARK matter, GRAVITATIONAL lenses
Abstract: We present a measurement of the gravitational lensing deflection power spectrum reconstructed with two seasons of cosmic microwave background polarization data from the Polarbear experiment. Observations were taken at 150 GHz from 2012 to 2014 and surveyed three patches of sky totaling 30 square degrees. We test the consistency of the lensing spectrum with a cold dark matter cosmology and reject the no-lensing hypothesis at a confidence of 10.9σ, including statistical and systematic uncertainties. We observe a value of AL = 1.33 ± 0.32 (statistical) ±0.02 (systematic) ±0.07 (foreground) using all polarization lensing estimators, which corresponds to a 24% accurate measurement of the lensing amplitude. Compared to the analysis of the first-year data, we have improved the breadth of both the suite of null tests and the error terms included in the estimation of systematic contamination. [ABSTRACT FROM AUTHOR]
Published: 2020
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24. Field test of GMPLS all-optical path rerouting.

Author: S. Tanaka, S. Asano, T. Fujino, H. Ishimatsu, T. Hashimoto, A. Inomata, T. Kanda, M. Yagi, S. Ryu, S. Yoneda, T. Nishii, N. Yoshii, A. Sasaki, K. Fukada, T. Fujii, T. Saito, E. Horiuchi, S. Tamura, and M. Tanabe
Abstract: Router-to-router all-optical wavelength path rerouting using generalized multiprotocol label switching protocol has been successfully carried out including photonic cross-connect and dense wavelength-division-multiplexing equipment. The rerouting time was measured to be shorter than 7 s. [ABSTRACT FROM PUBLISHER]
Published: 2005
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25. Steady State Operation of a Field-Reversed Configuration Plasma by NBI

Author: T., \\'Asai, T., Takahashi, Y., Matsuzawa, T., Fujino, Y., Hirano, N., Mizuguchi, and Y.\\', Tomita

26. The microstructure characterization and phase composition analysis of (Bi,Pb)-2223 Ag/tapes with SnO, MgO and Ag2O mix-doping.

Author: X Y Lu, D Yi, T Fujino, and A Nagata
Published: 2018
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27. Translocation mechanism and the role of aerenchyma in nanoplastic translocation in Myriophyllum sp. "Roraima" and physiological responses.

Author: Liu Z, Senavirathna MDHJ, Fujino T, and Kaneko Y
Abstract: Nanoplastics have become a growing concern due to their potential impact on freshwater vegetation. The uptake, translocation, and effects of 0.05-µm nanoplastics on Myriophyllum sp. "Roraima" were investigated, along with the role of aerenchyma in nanoplastic transport. Microscopic observations revealed nanoplastic particle adsorption to the plant surface and entry into the roots and stems, with higher abundance and more dispersed distribution by direct contact. Nanoplastic particles were detected in the plant stem, primarily concentrated in regions adjacent to the aerenchyma. No morphological effects were observed. Induced changes in photosynthesis, including increased maximum quantum efficiency of photosystem II (Fv/Fm), decreased non-photochemical quenching (NPQ), decreased photosynthetic pigments, and increased photoprotective pigments, were recognized. Additionally, hydrogen peroxide levels and antioxidant enzyme activities varied in response to nanoplastic exposure. This study provides insights into the impact of nanoplastics on Myriophyllum sp. "Roraima" and has reviewed the underlying mechanisms, highlighting the role of aerenchyma in nanoplastic transport within the plant. Moreover, this study contributes to the understanding of the potential impacts of nanoplastic pollution on freshwater macrophytes while acknowledging the influence of phyto-anatomical structure on nanoplastic translocation., Competing Interests: Declarations. Ethical approval: Not applicable. Consent to participate: Not applicable. Consent for publication: All authors participated and approved the final manuscript to be published. Competing interests: The authors declare no competing interests., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Published: 2024
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28. Synthesis of Stable Hypervalent Bromine(III) Complexes by in Situ Oxidation with Lewis Acids Containing sp -Hybridized Nitrogen.

Author: Fujino T, Hyodo T, Otani Y, Yamaguchi K, and Ohwada T
Abstract: Stable hypervalent bromine(III) compounds were synthesized via aryl bromine oxidation with sp -hybridized nitrogen cations generated by oxime N-O bond cleavage in trifluoroacetic acid. The resulting intramolecular N-Br hypervalent bond is effectively stabilized by the planar xanthone structure. The structures and physicochemical properties of these λ 3 -bromanes were characterized by X-ray crystallography, cyclic voltammetry, UV-vis spectroscopy, and computational analysis.
Published: 2024
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29. Clinical and pathological characteristics of immune checkpoint inhibitor-related fulminant myocarditis.

Author: Izumi R, Hashimoto T, Kisanuki H, Ikuta K, Otsuru W, Asakawa S, Yamamoto S, Misumi K, Fujino T, Shinohara K, Matsushima S, Hosokawa K, Katsuki S, Mori T, Hashisako M, Tateishi Y, Iwasaki T, Oda Y, Kinugawa S, and Abe K
Abstract: The advent of immune checkpoint inhibitors (ICIs) has significantly improved cancer treatment. With the increasing use of ICIs, ICI-related myocarditis has been recognized. However, an evidence-based therapeutic strategy has not been established because of the limited knowledge on ICI-related myocarditis. Here, we present four cases of ICI-related fulminant myocarditis (FM). Three of the four cases resulted in fatal outcomes despite aggressive treatment with mechanical circulatory support and immunosuppressive therapy with corticosteroids. Given the poor prognosis of ICI-FM, the establishment of rapid and adequate therapeutic interventions on the basis of clinical and pathological evaluation is imperative., Competing Interests: Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests., (© 2024. The Author(s).)
Published: 2024
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30. A rare case of infiltrative optic neuropathy caused by vitreoretinal lymphoma with hyperreflective deposits in the intraretinal and subretinal pigment epithelial layers prior to the disease onset.

Author: Kuji T, Komoto S, Maruyama K, Fujimoto S, Fujino T, Kitaguchi Y, Shimojo H, Morimoto T, and Nishida K
Subjects: Humans, Female, Aged, 80 and over, Tomography, Optical Coherence methods, Vitrectomy, Vitreous Body pathology, Intraocular Lymphoma diagnosis, Intraocular Lymphoma pathology, Magnetic Resonance Imaging, Lymphoma, B-Cell diagnosis, Lymphoma, B-Cell complications, Lymphoma, B-Cell pathology, Visual Acuity, Retinal Neoplasms diagnosis, Optic Nerve Diseases diagnosis, Optic Nerve Diseases etiology, Retinal Pigment Epithelium pathology
Abstract: Background: To describe a rare case of infiltrative optic neuropathy (ION) caused by vitreoretinal lymphoma (VRL) with hyperreflective deposits in the intraretinal and subretinal pigment epithelial (RPE) layers before the disease onset., Case Presentation: An 87-year-old Japanese female, previously treated for unexplained uveitis in the right eye, was referred for further evaluation. Despite the absence of intraocular inflammation or vitreous opacification (VO), yellowish-white deposits were noted in the macula, and OCT revealed hyperreflective deposits in the intraretinal and sub-RPE layers. One month later, she returned with acute visual deterioration. Optic disc swelling and disc hemorrhage were observed without VO or intraocular inflammation. Magnetic resonance imaging (MRI) showed no abnormalities. One week later, VO developed and we performed a 25-gauge vitrectomy. Cytology, flow cytometry, and gene rearrangement confirmed malignant B-cell lymphoma. The diagnosis of ION secondary to VRL was made, and intravitreal methotrexate injections were administered a total of 6 times. Six months postoperatively, VO and optic disc swelling resolved, and visual acuity improved to 20/50, with no recurrence on MRI., Conclusions: Although there were reports on VRL advanced from hyperreflective deposits in the intraretinal or sub-RPE layers, there have been no studies that these OCT findings has progressed to ION with VRL. When differentiating optic neuropathy, OCT may assist in the diagnosis by evaluating intraretinal and sub-RPE findings., Competing Interests: Declarations Ethics approval and consent to participate Not applicable. Consent for publication Written informed consent was obtained from the patient for publication of this case report and all accompanying images. A copy of the consent form is kept at our facility. Competing interests The authors declare no competing interests., (© 2024. The Author(s).)
Published: 2024
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31. Effectiveness of Vericiguat on right ventricle to pulmonary artery uncoupling associated with heart failure with reduced ejection fraction.

Author: Hashimoto T, Yoshitake T, Suenaga T, Yamamoto S, Fujino T, Shinohara K, Matsushima S, Ide T, Kinugawa S, and Abe K
Subjects: Humans, Male, Female, Retrospective Studies, Aged, Middle Aged, Treatment Outcome, Follow-Up Studies, Heart Ventricles physiopathology, Heart Ventricles diagnostic imaging, Heart Ventricles drug effects, Heterocyclic Compounds, 2-Ring, Heart Failure drug therapy, Heart Failure physiopathology, Stroke Volume drug effects, Stroke Volume physiology, Pulmonary Artery drug effects, Pulmonary Artery physiopathology, Pulmonary Artery diagnostic imaging, Pyrimidines therapeutic use
Abstract: Backgrounds: A soluble guanylyl cyclase stimulator vericiguat has been shown to reduce cardiovascular mortality or hospitalization for heart failure in patients with worsening heart failure in the VICTORIA study. However, little is known about the effects of vericiguat on biventricular structure and function., Methods and Results: A retrospective analysis of 63 consecutive patients with heart failure with reduced ejection fraction (HFrEF) who were treated with vericiguat was performed. Clinical data and echocardiographic parameters were compared between baseline and follow-up after the initiation of vericiguat. The median follow-up duration was 266 days. Treatment with vericiguat significantly reduced the plasma BNP levels (log-transformed) compared to baseline (2.46 ± 0.51 vs. 2.14 ± 0.58, p < 0.0001). Left ventricular end-diastolic volume index and left ventricular end-systolic volume index were significantly reduced (LVEDVI, 113.5 ± 46.3 vs. 103.6 ± 51.0, p = 0.0056; LVESVI, 82.0 ± 41.9 vs. 72.8 ± 44.7, p = 0.0077; respectively). The tricuspid annular plane systolic excursion to pulmonary artery systolic pressure (TAPSE/PASP) ratio, an indicator of right ventricle-pulmonary artery (RV-PA) coupling, increased significantly after the treatment (0.56 ± 0.29 vs. 0.92 ± 1.09, p < 0.0001). Univariate and multivariate analyses showed that the treatment effects of vericiguat on BNP levels, LV reverse remodeling, and RV-PA coupling were not correlated with the achievement of the quadruple therapy with beta-blockers, renin-angiotensin system inhibitors, mineralocorticoid inhibitors, and sodium-glucose cotransporter-2 inhibitors, nor with worsening heart failure (WHF)., Conclusion: Treatment with vericiguat improved adverse LV remodeling and RV-PA uncoupling in HFrEF patients. These effects were independent of WHF and achieving the quadruple therapy. Patients with HFrEF may benefit from early initiation of vericiguat to prevent biventricular adverse remodeling., (Copyright © 2024 Elsevier B.V. All rights reserved.)
Published: 2024
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32. Reply to the Letter.

Author: Wada R, Shinohara M, Koike H, Nakanishi R, Fujino T, and Ikeda T
Published: 2024
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33. A chromosome-level genome assembly of a model conifer plant, the Japanese cedar, Cryptomeria japonica D. Don.

Author: Fujino T, Yamaguchi K, Yokoyama TT, Hamanaka T, Harazono Y, Kamada H, Kobayashi W, Ujino-Ihara T, Uchiyama K, Matsumoto A, Izuno A, Tsumura Y, Toyoda A, Shigenobu S, Moriguchi Y, Ueno S, and Kasahara M
Subjects: Molecular Sequence Annotation, Genomics methods, Cryptomeria genetics, Genome, Plant, Chromosomes, Plant genetics
Abstract: Background: The Japanese cedar (Cryptomeria japonica D. Don) is one of the most important Japanese forest trees, occupying approximately 44% of artificial forests and planted in East Asia, the Azores Archipelago, and certain islands in the Indian Ocean. Although the huge genome of the species (ca. 9 Gbp) with abundant repeat elements may have represented an obstacle for genetic analysis, this species is easily propagated by cutting, flowered by gibberellic acid, transformed by Agrobacterium, and edited by CRISPR/Cas9. These characteristics of C. japonica recommend it as a model conifer species for which reference genome sequences are necessary., Results: Herein, we report the first chromosome-level assembly of C. japonica (2n = 22) using third-generation selfed progeny (estimated homozygosity rate = 0.96). Young leaf tissue was used to extract high molecular weight DNA (> 50 kb) for HiFi PacBio long-read sequencing and to construct an Hi-C/Omni-C library for Illumina short-read sequencing. The 29× and 26× genome coverage of HiFi and Illumina reads, respectively, for de novo assembly yielded 2,651 contigs (9.1 Gbp, N50 contig size 12.0 Mbp). Hi-C analysis mapped 97% of the nucleotides on 11 chromosomes. The assembly was verified through comparison with a consensus linkage map comprising 7,781 markers. BUSCO analysis identified ∼ 91% conserved genes., Conclusions: Annotations of genes and comparisons of repeat elements with other Cupressaceae and Pinaceae species provide a fundamental resource for conifer research., (© 2024. The Author(s).)
Published: 2024
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34. Subsartorial canal catheter: a reliable catheter placement technique for continuous proximal adductor canal block.

Author: Fujino T, Yoshida T, Kawagoe I, and Nakamoto T
Abstract: Competing Interests: Competing interests: None declared.
Published: 2024
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35. Clinical and Histopathological Characteristics of Patients With Myocarditis After mRNA COVID-19 Vaccination.

Author: Omori T, Maruyama K, Ohta-Ogo K, Hatakeyama K, Ishibashi-Ueda H, Onoue K, Nagai T, Kato S, Okumura T, Oikawa M, Amiya E, Yoshizawa S, Suzuki T, Goto H, Nakamura K, Fujino T, Moriwaki K, Nakamori S, Anzai T, Sakata Y, Hiroe M, Imanaka-Yoshida K, and Dohi K
Abstract: Background: The effects of myocarditis after mRNA COVID-19 vaccination (mCV) on myocardial tissue, and the association between cardiomyocyte injury and clinical presentation, are not fully understood., Methods and Results: We retrospectively registered patients clinically diagnosed with myocarditis after the first or second mCV who underwent endomyocardial biopsy or autopsy from 42 participating centers in Japan. We investigated the histological features and their association with clinical presentation based on cardiomyocyte injury. Forty patients who underwent endomyocardial biopsy were included in the study. Of these, 19 (47.5%) showed mild lymphocytic infiltration and interstitial edema without cardiomyocyte injury. The remaining 21 (52.5%) patients showed cardiomyocyte injury accompanied by infiltrating inflammatory cells: 11 with lymphocytic infiltration, 7 with eosinophilic infiltration, and 3 with myocarditis with both lymphocyte and eosinophil infiltration. Compared with patients without cardiomyocyte injury, those with cardiomyocyte injury were clinically characterized by older age, a balanced sex distribution, less frequent chest pain, and a lower left ventricular ejection fraction. Fifteen of 21 (71.4%) patients with cardiomyocyte injury developed fulminant myocarditis, with 13 (86.7%) requiring mechanical circulatory support; in contrast, none of those without cardiomyocyte injury developed fulminant myocarditis (P<0.001)., Conclusions: Our histological examination of patients with myocarditis after mCV revealed varying degrees of cardiomyocyte injury, ranging from pronounced to absent, along with various types of myocarditis. Cardiomyocyte injury was strongly associated with the severity of myocarditis.
Published: 2024
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36. Somatic mutation rates scale with time not growth rate in long-lived tropical trees.

Author: Satake A, Imai R, Fujino T, Tomimoto S, Ohta K, Na'iem M, Indrioko S, Widiyatno W, Purnomo S, Morales AM, Nizhynska V, Tani N, Suyama Y, Sasaki E, and Kasahara M
Subjects: Indonesia, Borneo, Mutation, Dipterocarpaceae genetics, Dipterocarpaceae growth & development, Mutation Rate, Trees genetics, Trees growth & development, Tropical Climate
Abstract: The rates of appearance of new mutations play a central role in evolution. However, mutational processes in natural environments and their relationship with growth rates are largely unknown, particular in tropical ecosystems with high biodiversity. Here, we examined the somatic mutation landscapes of two tropical trees, Shorea laevis (slow-growing) and S. leprosula (fast-growing), in central Borneo, Indonesia. Using newly constructed genomes, we identified a greater number of somatic mutations in tropical trees than in temperate trees. In both species, we observed a linear increase in the number of somatic mutations with physical distance between branches. However, we found that the rate of somatic mutation accumulation per meter of growth was 3.7-fold higher in S. laevis than in S. leprosula . This difference in the somatic mutation rate was scaled with the slower growth rate of S. laevis compared to S. leprosula, resulting in a constant somatic mutation rate per year between the two species. We also found that somatic mutations are neutral within an individual, but those mutations transmitted to the next generation are subject to purifying selection. These findings suggest that somatic mutations accumulate with absolute time and older trees have a greater contribution towards generating genetic variation., Competing Interests: AS, RI, TF, ST, KO, MN, SI, WW, SP, AM, VN, NT, YS, ES, MK No competing interests declared, (© 2023, Satake, Imai et al.)
Published: 2024
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37. Robust anti-myeloma effect of TAS0612, an RSK/AKT/S6K inhibitor, with venetoclax regardless of cytogenetic abnormalities.

Author: Okamoto H, Mizutani S, Tsukamoto T, Katsuragawa-Taminishi Y, Kawaji-Kanayama Y, Mizuhara K, Muramatsu A, Isa R, Fujino T, Shimura Y, Ichikawa K, and Kuroda J
Abstract: Multiple myeloma (MM) remains a difficult-to-treat disease even with the latest therapeutic advances due to the complex, overlapping, and heterogeneous cytogenetic, genetic, and molecular abnormalities. To address this challenging problem, we previously identified the universal and critical roles of RSK2 and AKT, the effector signaling molecules downstream of PDPK1, regardless of cytogenetic and genetic profiles. Based on this, in this study, we investigated the anti-myeloma potency of TAS0612, a triple inhibitor against RSK, including RSK2, AKT, and S6K. Treatment with TAS0612 exerted the anti-proliferative effect via cell cycle blockade and the induction of apoptosis in human myeloma-derived cell lines (HMCLs) with diverse cytogenetic and genetic profiles. Ex vivo treatment with TAS0612 also significantly reduced the viability of patient-derived primary myeloma cells with diverse cytogenetic profiles. TAS0612 simultaneously caused the upregulation of several tumor suppressor genes, modulated prognostic genes according to the MMRF CoMMpass data, and downregulated a series of Myc- and mTOR-related genes. Moreover, the combination of TAS0612 with venetoclax (VEN) showed the synergy in inducing apoptosis in HMCLs irrespective of the t(11;14) translocation status. TAS0612 alone and combined with VEN are new potent candidate therapeutic strategies for MM, regardless of cytogenetic/genetic profiles, facilitating its future clinical development., (© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)
Published: 2024
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38. Health Effects of Methylmercury in Coastal Areas of the Yatsushiro Sea, Far from Minamata.

Author: Takaoka S, Fujino T, Shigeoka SI, and Itai Y
Abstract: Minamata disease, caused by ingesting seafood contaminated with methylmercury dumped by corporations, was discovered in 1956; however, there has been no continued investigation to determine the full extent of the damage. Since 2004, it has been discovered that affected patients can be found in areas further away from Minamata than previously known. In the present study, we investigated various symptoms and somatosensory disturbances in western Miyanokawachi District, northern Himedo District, southwestern Nagashima District, and the uncontaminated Amami district and calculated the proportion of patients with sensory disturbances as a percentage of the population in each area. Both touch and pain sensations, with a predominance of the peripheral extremities, were observed in 58.6% of patients in Miyanokawachi, 53.9% in Himedo, 37.8% in Nagashima, and 1.4% in Amami. The lowest estimates of attributable fractions of the exposed group for four-limb-predominant sensory disturbance in the population of the contaminated districts were 94.1% in Miyanokawachi, 94.6% in Himedo, and 91.4% in Nagashima, and general and perioral sensory disturbances were also high. This suggests that the presence or absence of these sensory disturbances is useful in the diagnosis of Minamata disease, even in more distant parts of the Yatsushiro Sea area.
Published: 2024
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39. Data Poisoning Attack against Neural Network-Based On-Device Learning Anomaly Detector by Physical Attacks on Sensors.

Author: Ino T, Yoshida K, Matsutani H, and Fujino T
Abstract: In this paper, we introduce a security approach for on-device learning Edge AIs designed to detect abnormal conditions in factory machines. Since Edge AIs are easily accessible by an attacker physically, there are security risks due to physical attacks. In particular, there is a concern that the attacker may tamper with the training data of the on-device learning Edge AIs to degrade the task accuracy. Few risk assessments have been reported. It is important to understand these security risks before considering countermeasures. In this paper, we demonstrate a data poisoning attack against an on-device learning Edge AI. Our attack target is an on-device learning anomaly detection system. The system adopts MEMS accelerometers to measure the vibration of factory machines and detect anomalies. The anomaly detector also adopts a concept drift detection algorithm and multiple models to accommodate multiple normal patterns. For the attack, we used a method in which measurements are tampered with by exposing the MEMS accelerometer to acoustic waves of a specific frequency. The acceleration data falsified by this method were trained on an anomaly detector, and the result was that the abnormal state could not be detected.
Published: 2024
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40. Augmenting CAR T-cell Functions with LIGHT.

Author: Cai W, Tanaka K, Mi X, Rajasekhar VK, Khan JF, Yoo S, de Stanchina E, Rahman J, Mathew S, Abrahimi P, Souness S, Purdon TJ, McDowell JR, Meyerberg J, Fujino T, Healey JH, Abdel-Wahab O, Scheinberg DA, Brentjens RJ, and Daniyan AF
Subjects: Humans, Animals, Cell Line, Tumor, Cytotoxicity, Immunologic, Mice, Lymphotoxin beta Receptor immunology, Lymphotoxin beta Receptor metabolism, Antigens, Neoplasm immunology, Xenograft Model Antitumor Assays, Neoplasms immunology, Neoplasms therapy, Receptors, Chimeric Antigen immunology, Receptors, Chimeric Antigen genetics, Receptors, Chimeric Antigen metabolism, Immunotherapy, Adoptive methods, Tumor Necrosis Factor Ligand Superfamily Member 14 metabolism, T-Lymphocytes immunology
Abstract: Chimeric antigen receptor (CAR) T-cell therapy has resulted in remarkable clinical success in the treatment of B-cell malignancies. However, its clinical efficacy in solid tumors is limited, primarily by target antigen heterogeneity. To overcome antigen heterogeneity, we developed CAR T cells that overexpress LIGHT, a ligand of both lymphotoxin-β receptor on cancer cells and herpes virus entry mediator on immune cells. LIGHT-expressing CAR T cells displayed both antigen-directed cytotoxicity mediated by the CAR and antigen-independent killing mediated through the interaction of LIGHT with lymphotoxin-β receptor on cancer cells. Moreover, CAR T cells expressing LIGHT had immunostimulatory properties that improved the cells' proliferation and cytolytic profile. These data indicate that LIGHT-expressing CAR T cells may provide a way to eliminate antigen-negative tumor cells to prevent antigen-negative disease relapse., (©2024 American Association for Cancer Research.)
Published: 2024
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41. Different Impact of Immunosuppressive Therapy on Cardiac Outcomes in Systemic Versus Isolated Cardiac Sarcoidosis.

Author: Masunaga T, Hashimoto T, Fujino T, Ohtani K, Ishikawa Y, Yoshitake T, Shinohara K, Matsushima S, Ide T, Yamasaki Y, Isoda T, Baba S, Ishigami K, Tsutsui H, and Kinugawa S
Subjects: Humans, Male, Female, Middle Aged, Retrospective Studies, Aged, Prognosis, Adult, Positron-Emission Tomography methods, Tachycardia, Ventricular drug therapy, Sarcoidosis drug therapy, Sarcoidosis complications, Cardiomyopathies drug therapy, Cardiomyopathies physiopathology, Immunosuppressive Agents therapeutic use
Abstract: Isolated cardiac sarcoidosis (iCS) is increasingly recognized; however, its prognosis and the efficacy of immunosuppressive therapy remain undetermined. We aimed to compare the prognosis of iCS and systemic sarcoidosis including cardiac involvement (sCS) under immunosuppressive therapy.We retrospectively reviewed the clinical data of 42 patients with sCS and 30 patients with iCS diagnosed at Kyushu University Hospital from 2004 through 2022. We compared the characteristics and the rate of adverse cardiac events including cardiac death, fatal ventricular tachyarrhythmia, and heart failure hospitalization between the 2 groups. The median follow-up time was 1535 [interquartile range, 630-2555] days, without a significant difference between the groups. There were no significant differences in gender, NYHA class, or left ventricular ejection fraction. Immunosuppressive agents were administered in 86% of sCS and in 73% of iCS patients (P = 0.191). When analyzed only with patients receiving immunosuppressive therapy (sCS, n = 36; iCS, n = 21), the cardiac event-free survival was significantly lower in iCS than sCS (37% versus 79%, P = 0.002). Myocardial LGE content at the initial diagnosis was comparable in both groups. The disease activity was serially evaluated in 26 sCS and 16 iCS patients by quantitative measures of FDG-PET including cardiac metabolic volume and total lesion glycolysis, representing 3-dimensional distribution and intensity of inflammation in the entire heart. Although iCS patients had lower baseline disease activity than sCS patients, immunosuppressive therapy did not attenuate disease activity in iCS in contrast to sCS.iCS showed a poorer response to immunosuppressive therapy and a worse cardiac prognosis compared to sCS despite lower baseline disease activity.
Published: 2024
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42. Right Ventricular to Pulmonary Artery Uncoupling Is Associated With Impaired Exercise Capacity in Patients With Transthyretin Cardiac Amyloidosis.

Author: Hashimoto T, Ikuta K, Yamamoto S, Yoshitake T, Suenaga T, Nakashima S, Kai T, Misumi K, Fujino T, Shinohara K, Matsushima S, Atsumi R, Isoda T, Kinugawa S, and Abe K
Abstract: Background: Exercise capacity is related to mortality and morbidity in heart failure (HF) patients. Determinants of exercise capacity in transthyretin cardiac amyloidosis (ATTR-CA) have not been established., Methods and Results: This single-center study retrospectively evaluated ATTR-CA patients and patients with non-amyloidosis HF with preserved/mildly reduced ejection fraction (HFpEF/HFmrEF) (n=32 and n=51, respectively). In the ATTR-CA group, the median age was 75.5 years (interquartile range [IQR] 71.3-78.8 years), 90.6% were male, and the median left ventricular (LV) ejection fraction was 53.5% (IQR 41.4-65.6%). Cardiopulmonary exercise tests revealed a median peak oxygen consumption and anaerobic threshold of 15.9 (IQR 11.6-17.4) and 10.6 (IQR 8.5-12.0] mL/min/kg, respectively, and ventilatory efficiency (minute ventilation/carbon dioxide production [V̇ E /V̇ CO2 ] slope) of 35.5 (IQR 32.0-42.5). Among exercise variables, V̇ E /V̇ CO2 slope has the greatest prognostic value. Univariate analysis revealed a significant correlation between V̇ E /V̇ CO2 slope and age, LV global longitudinal strain, tricuspid annular plain systolic excursion/pulmonary arterial systolic pressure (TAPSE/PASP) ratio, and mixed venous oxygen saturation. In multivariate analyses, the TAPSE/PASP ratio was an independent predictor of V̇ E /V̇ CO2 slope (95% confidence interval -44.5, -10.8; P=0.0067). In non-amyloidosis HFpEF/HFmrEF patients, the TAPSE/PASP ratio was not independently correlated with V̇ E /V̇ CO2 slope., Conclusions: Right ventricular-pulmonary artery coupling estimated by the TAPSE/PASP ratio determines exercise capacity in ATTR-CA patients. This highlights the importance of early therapeutic intervention against underappreciated right ventricular dysfunction associated with ATTR-CA.
Published: 2024
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43. NVL-655 Is a Selective and Brain-Penetrant Inhibitor of Diverse ALK-Mutant Oncoproteins, Including Lorlatinib-Resistant Compound Mutations.

Author: Lin JJ, Horan JC, Tangpeerachaikul A, Swalduz A, Valdivia A, Johnson ML, Besse B, Camidge DR, Fujino T, Yoda S, Nguyen-Phuong L, Mizuta H, Bigot L, Nobre C, Lee JB, Yu MR, Mente S, Sun Y, Kohl NE, Porter JR, Shair MD, Zhu VW, Felip E, Cho BC, Friboulet L, Hata AN, Pelish HE, and Drilon A
Abstract: Three generations of tyrosine kinase inhibitors (TKI) have been approved for anaplastic lymphoma kinase (ALK) fusion-positive non-small cell lung cancer. However, none address the combined need for broad resistance coverage, brain activity, and avoidance of clinically dose-limiting TRK inhibition. NVL-655 is a rationally designed TKI with >50-fold selectivity for ALK over 96% of the kinome tested. In vitro, NVL-655 inhibits diverse ALK fusions, activating alterations, and resistance mutations, showing ≥100-fold improved potency against ALKG1202R single and compound mutations over approved ALK TKIs. In vivo, it induces regression across 12 tumor models, including intracranial and patient-derived xenografts. NVL-655 inhibits ALK over TRK with 22-fold to >874-fold selectivity. These preclinical findings are supported by three case studies from an ongoing first-in-human phase I/II trial of NVL-655 which demonstrate preliminary proof-of-concept clinical activity in heavily pretreated patients with ALK fusion-positive non-small cell lung cancer, including in patients with brain metastases and single or compound ALK resistance mutations. Significance: By combining broad activity against single and compound ALK resistance mutations, brain penetrance, and selectivity, NVL-655 addresses key limitations of currently approved ALK inhibitors and has the potential to represent a distinct advancement as a fourth-generation inhibitor for patients with ALK-driven cancers., (©2024 The Authors; Published by the American Association for Cancer Research.)
Published: 2024
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44. Intermittent Versus Daily Trimethoprim/Sulfamethoxazole Regimens for Pneumocystis Pneumonia Prophylaxis: A Systematic Review and Meta-analysis.

Author: Masaki T, Ishikawa K, Fujino T, Koyamada R, Kawai F, Ota E, and Mori S
Abstract: Background: In immunocompromised individuals, trimethoprim/sulfamethoxazole (TMP/SMX) for Pneumocystis pneumonia (PCP) prophylaxis has adverse events, and the optimal dosage is unclear. The objective of this study was to assess efficacy and safety of intermittent versus daily TMP/SMX for PCP prophylaxis., Methods: This systematic review included randomized controlled trials (RCTs) indexed in the Cochrane Central Register of Controlled Trials, PubMed, Ichushi, or Embase databases, published from database inception to September 2023. The inclusion criteria were adults taking intermittent or daily TMP/SMX for PCP prophylaxis. Risk of bias was assessed using the Cochrane risk-of-bias tool. The primary outcomes were PCP incidence, PCP-related mortality, and adverse events requiring temporary or permanent TMP/SMX discontinuation., Results: Four RCTs (N = 2808 patients) were included. PCP incidence did not differ significantly between the intermittent and daily regimen groups (risk ratio [RR], 1.17 [95% confidence interval {CI}, .89-1.53]; certainty: very low). There was no PCP-related mortality in the 3 RCTs reporting its outcome. Compared with the daily regimen group, the intermittent regimen group experienced significantly fewer adverse events requiring temporary or permanent TMP/SMX discontinuation (RR, 0.51 [95% CI, .42-.61]; certainty: low)., Conclusions: This systematic review and meta-analysis suggests that intermittent TMP/SMX regimens for PCP prophylaxis may be more tolerable than daily regimens and may have similar efficacy. Further RCTs are needed to apply this to current practice. Clinical Trials Registration. PROSPERO (CRD42022359102)., Competing Interests: Potential conflicts of interest. The authors: No reported conflicts of interest., (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
Published: 2024
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45. KIT-13, a novel plasmalogen derivative, attenuates neuroinflammation and amplifies cognition.

Author: Hossain MS, Mawatari S, Honsho M, Okauchi T, and Fujino T
Abstract: Plasmalogens (Pls) are specialized phospholipids integral to brain health, whose decline due to aging and stress contributes to cognitive impairment and neuroinflammation. This study explores the potential of a novel Pls derivative, KIT-13 (1-O-octadecyl-2-arachidonoyl-sn-glycerol-3-phosphoethanolamine), in mitigating neuroinflammation and enhancing cognition. When administered to mice, KIT-13 exhibited potent memory enhancement attributed to upregulated brain-derived neurotrophic factor (BDNF), a key player in cognitive processes. In vitro experiments with neuronal cells revealed KIT-13's ability to induce robust cellular signaling, surpassing natural plasmalogens. KIT-13 also promoted neurogenesis and inhibited apoptosis of neuronal-like cells, highlighting its potential in fostering neuronal growth and plasticity. Additionally, KIT-13 treatments reduced pro-inflammatory cytokine expression and attenuated glial activation in the brain. KIT-13's superior efficacy over natural Pls positions it as a promising therapeutic candidate for neurodegenerative conditions such as Alzheimer's disease, characterized by cognitive decline and neuroinflammation. This study presents KIT-13 as an innovative approach for addressing cognitive impairment and neuroinflammatory pathologies., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Hossain, Mawatari, Honsho, Okauchi and Fujino.)
Published: 2024
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46. Electrophysiological evidence of right atrial epicardial connections in a case with recurrent common atrial flutter.

Author: Shinohara M, Fujino T, Kikushima H, Wada R, Yao S, Yano K, Akitsu K, and Ikeda T
Subjects: Humans, Male, Pericardium physiopathology, Pericardium surgery, Heart Conduction System physiopathology, Heart Conduction System surgery, Electrocardiography, Electrophysiologic Techniques, Cardiac, Aged, Middle Aged, Atrial Flutter surgery, Atrial Flutter physiopathology, Catheter Ablation methods, Heart Atria physiopathology, Heart Atria surgery, Recurrence
Abstract: The majority of the cavotricuspid isthmus (CTI) region consists of discretely arranged muscle bundles separated by connective tissue. Heterogeneity in the anatomic arrangement of the muscle bundles results in differences in the endocardial and epicardial activation patterns. We present a case of recurrent atrial flutter (AFL) despite the presence of a complete endocardial CTI block. We found epicardial-endocardial breakthrough (EEB) sites on the right atrial high septum. In addition, the epicardial excitation confirmed by endocardial activation mapping was detected as far-field potentials. Radiofrequency ablation was performed at the EEB site. No AFL has recurred for 12 months after the present procedure., (© 2024 Wiley Periodicals LLC.)
Published: 2024
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47. "Kyushu-style" collaboration between the implantable ventricular assist device implantation and management centers: a republication of the article published in Japanese journal of artificial organs.

Author: Ushijima T, Fujino T, Komman H, Toyosawa M, Sadamatsu S, and Shiose A
Subjects: Humans, Heart Failure therapy, Heart Failure surgery, Japan, Prosthesis Implantation, Heart-Assist Devices statistics & numerical data
Abstract: Collaboration between the implantation centers, management centers, and regional core hospitals is a key factor in securing long-term implantable ventricular assist device (VAD) management. In Kyushu, a management system for patients with implantable VADs has been established at the prefectural and regional levels. Presently, six implantable VAD implantation centers and seven management centers exists in the eight prefectures of Kyushu and Okinawa, with at least one specialized VAD centers in each prefecture. This collaborative management system allows patients with VADs to receive seamless treatment based on the same management concept wherever they live. In fact, approximately half of the present outpatients treated at our center reside outside the prefecture and are managed in collaboration with management centers and regional core hospitals. Among our patients, there were no significant differences in survival or rehospitalization-free rates between patients with VADs in and out of the prefecture, suggesting that the place of residence did not affect the outcome. With the increase in the number of patients with VADs and the diversification of patients, patient management has become more complex. Mutual collaboration between the implantation centers, management centers, and regional core hospitals, is essential to improve the quality of VAD management. This review was created based on a translation of the Japanese review written in the Japanese Journal of Artificial Organs in 2023 (Vol. 52, No. 1, pp. 85-88), with some modifications., (© 2024. The Japanese Society for Artificial Organs.)
Published: 2024
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48. JCS/JSCVS/JCC/CVIT 2023 guideline focused update on indication and operation of PCPS/ECMO/IMPELLA.

Author: Nishimura T, Hirata Y, Ise T, Iwano H, Izutani H, Kinugawa K, Kitai T, Ohno T, Ohtani T, Okumura T, Ono M, Satomi K, Shiose A, Toda K, Tsukamoto Y, Yamaguchi O, Fujino T, Hashimoto T, Higashi H, Higashino A, Kondo T, Kurobe H, Miyoshi T, Nakamoto K, Nakamura M, Saito T, Saku K, Shimada S, Sonoda H, Unai S, Ushijima T, Watanabe T, Yahagi K, Fukushima N, Inomata T, Kyo S, Minamino T, Minatoya K, Sakata Y, and Sawa Y
Subjects: Humans, Cardiology, Extracorporeal Membrane Oxygenation
Published: 2024
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49. SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation.

Author: Chang YH, Yamamoto K, Fujino T, Wang TW, Sugimoto E, Zhang W, Yabushita T, Suzaki K, Pietsch EC, Weir BA, Crescenzo R, Cowley GS, Attar R, Philippar U, Wunderlich M, Mizukawa B, Zheng Y, Enomoto Y, Imai Y, Kitamura T, and Goyama S
Subjects: Animals, Mice, Humans, Mice, Inbred C57BL, Cell Line, Tumor, Immunologic Surveillance, Monocytes metabolism, Monocytes immunology, Apoptosis, Leukemia, Myeloid, Acute pathology, Leukemia, Myeloid, Acute immunology, Leukemia, Myeloid, Acute metabolism, Leukemia, Myeloid, Acute genetics, Killer Cells, Natural immunology, Killer Cells, Natural metabolism, Cell Differentiation, Histone-Lysine N-Methyltransferase metabolism, Histone-Lysine N-Methyltransferase genetics
Abstract: Monocytic acute myeloid leukemia (AML) responds poorly to current treatments, including venetoclax-based therapy. We conducted in vivo and in vitro CRISPR-Cas9 library screenings using a mouse monocytic AML model and identified SETDB1 and its binding partners (ATF7IP and TRIM33) as crucial tumor promoters in vivo. The growth-inhibitory effect of Setdb1 depletion in vivo is dependent mainly on natural killer (NK) cell-mediated cytotoxicity. Mechanistically, SETDB1 depletion upregulates interferon-stimulated genes and NKG2D ligands through the demethylation of histone H3 Lys9 at the enhancer regions, thereby enhancing their immunogenicity to NK cells and intrinsic apoptosis. Importantly, these effects are not observed in non-monocytic leukemia cells. We also identified the expression of myeloid cell nuclear differentiation antigen (MNDA) and its murine counterpart Ifi203 as biomarkers to predict the sensitivity of AML to SETDB1 depletion. Our study highlights the critical and selective role of SETDB1 in AML with granulo-monocytic differentiation and underscores its potential as a therapeutic target for current unmet needs., Competing Interests: Declaration of interests T.K. has received research support from Janssen Research and Development for this study. E.C.P., R.C., G.S.C., B.A.W., R.A., and U.P. are employees of Janssen Research and Development., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Published: 2024
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50. Development and validation of a new scoring system to discriminate between uncomplicated and complicated appendicitis.

Author: Mori M, Shuto K, Kosugi C, Narushima K, Hirano A, Usui A, Nojima H, Hirota M, Sazuka T, Yamazaki M, Fujino T, Yamazaki K, Shimizu H, and Koda K
Subjects: Humans, Female, Male, Adult, Middle Aged, Retrospective Studies, Young Adult, Adolescent, Appendectomy, Logistic Models, Sensitivity and Specificity, Aged, Acute Disease, Appendicitis diagnosis, ROC Curve
Abstract: A scoring system to discriminate between uncomplicated and complicated appendicitis is beneficial to determine the optimal treatment for acute appendicitis. We developed a scoring system to discriminate between uncomplicated and complicated appendicitis and assessed the clinical usefulness of the scoring system using external validation. A total of 299 patients with acute appendicitis were retrospectively reviewed. One hundred and ninety-nine patients were assigned to the model development group, while the other 100 patients were assigned to an external validation group. A scoring system for complicated appendicitis was created using a final multivariate logistic regression model with six independent predictors. The area under the receiver operating characteristic curve of the scoring system was 0.882 (95% confidence interval: 0.835-0.929). The cutoff point of the scoring system was 12, and the sensitivity and specificity were 82.9% and 86.2%, respectively. In the external validation group, the area under the receiver operating characteristic curve of the scoring system was 0.868 (95% confidence interval 0.794-0.942), and there was no significant difference between the groups in the area under the receiver operating characteristic curve (P = 0.750). Our newly developed scoring system may contribute to prompt determination of the optimal treatment for acute appendicitis., (© 2024. The Author(s).)
Published: 2024
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