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1. Neurochemical, electroencephalographic and behavioral correlates of ethanol withdrawal in the rat.

Author

Edmonds HL Jr, Sytinsky IA, Sylvester DM, and Bellin SI

Subjects
Alcohol Withdrawal Delirium metabolism, Amino Acids metabolism, Animals, Electroencephalography, Ethanol adverse effects, Evoked Potentials drug effects, Humans, Male, Rats, Rats, Inbred Strains, Reflex, Startle drug effects, Seizures chemically induced, Sucrose administration & dosage, Alcohol Withdrawal Delirium psychology, Behavior, Animal drug effects, Brain drug effects, Neurotransmitter Agents metabolism, Psychoses, Alcoholic psychology
Published
1982

3. Changes of neurochemical and electrophysiological indices of rat brain under ethanol intoxication.

Author

Blagova OE, Budantsev AY, Sytinsky IA, and Lajtha A

Subjects
Alcohol Withdrawal Delirium metabolism, Animals, Catecholamines metabolism, Dopamine metabolism, Evoked Potentials drug effects, Glutamate Decarboxylase metabolism, Humans, Male, Rats, Rats, Inbred Strains, Serotonin metabolism, Time Factors, gamma-Aminobutyric Acid metabolism, Alcoholic Intoxication metabolism, Brain metabolism
Abstract

It was found that acute ethanol intoxication caused an imbalance of the neurotransmitters in the CNS: accumulation of GABA and serotonin and depletion of catecholamines. Alcohol depression was characterized by suppression of the evoked potentials of the various rat brain structures. Under chronic ethanol intoxication of animals, relative stabilization of the electrophysiological indices of the rat brain activity was observed. This reflects the CNS adaptation to the constant ethanol presence in the blood. This state was also characterized by the relative stabilization of the serotonin system and by the increase of the catecholamine level. Withdrawal of ethanol after prolonged consumption caused accumulation of catecholamines in rat brain, depletion of serotonin and GABA, and increased excitability of the nervous structures. The changes of activity of the GABA- and monoaminergic systems are coupled to manifestation of symptoms of alcohol depression and convulsive reactions during ethanol withdrawal.

Published
1982
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4. Neurochemical basis of the therapeutic effect of gamma-aminobutyric acid and its derivatives.

Author

Sytinsky IA, Soldatenkov AT, and Lajtha A

Subjects
4-Aminobutyrate Transaminase metabolism, Animals, Axonal Transport drug effects, Brain enzymology, Brain Diseases drug therapy, Epilepsy drug therapy, Glutamate Decarboxylase metabolism, Humans, Mental Disorders drug therapy, Molecular Conformation, Neural Inhibition drug effects, Receptors, Neurotransmitter metabolism, Sarcoma, Experimental drug therapy, Sodium pharmacology, Synaptic Transmission drug effects, gamma-Aminobutyric Acid physiology, gamma-Aminobutyric Acid analogs & derivatives, gamma-Aminobutyric Acid therapeutic use
Published
1978
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5. Modern methods in treatment of chronic alcoholism: a review of the Soviet literature.

Author

Sytinsky IA and Gurevitch ZP

Subjects
Alcoholism drug therapy, Aversive Therapy, Chronic Disease, Conditioning, Classical, Disulfiram therapeutic use, Electronarcosis, Evaluation Studies as Topic, Follow-Up Studies, Humans, Hypnosis, Occupational Therapy, Psychodrama, Psychoses, Alcoholic therapy, Psychotherapy, Renal Dialysis, Substance Withdrawal Syndrome drug therapy, USSR, Alcoholism therapy
Published
1976
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6. Amino acid composition of cerebrospinal fluid in actue neuroinfections in children.

Author

Buryakova AV and Sytinsky IA

Subjects
Acute Disease, Adolescent, Adrenocorticotropic Hormone therapeutic use, Child, Child, Preschool, Chloramphenicol therapeutic use, Encephalitis drug therapy, Enterovirus Infections cerebrospinal fluid, Female, Glutamates cerebrospinal fluid, Glutamine cerebrospinal fluid, Humans, Hydrocortisone therapeutic use, Infant, Male, Meningitis drug therapy, Meningitis, Viral cerebrospinal fluid, Meningitis, Viral drug therapy, Mumps cerebrospinal fluid, Penicillins therapeutic use, Prednisolone therapeutic use, gamma-Aminobutyric Acid cerebrospinal fluid, Amino Acids cerebrospinal fluid, Encephalitis cerebrospinal fluid, Meningitis cerebrospinal fluid
Abstract

A survey of the cerebrospinal fluid (CSF) amino acids, glutamine, and glutamic and gamma-aminobutyric (GABA) acids was made in 168 children, aged 1 to 14 years, with various neurological infections. The glutamic acid and glutamine concentrations in the CSF of children with severe forms of acute serous and bacterial meningitis were about three to four times as great as in controls. The indices returned almost to normal during recovery. GABA is absent in normal CSF, but appeared in the CSF of patients with bacterial meningitis. Its determination may be used as an additional test to differentiate between serous and bacterial meningitis.

Published
1975
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7. A model of chronic alcohol intake under free-choice conditions.

Author

Guzikov BM, Ugolev AM, Kassil VG, and Sytinsky IA

Subjects
Animals, Behavior, Animal, Individuality, Male, Rats, Alcohol Drinking, Choice Behavior, Decision Making, Disease Models, Animal
Abstract

The preference of 42 Wistar male rats for alcoholic or non-alcoholic solutions of glucose was studied. Preference for the left or right position of drinking tubes did not appreciably influence the choice between the unequal solutions. Within the same strain of rats the majority of the animals had a high and a minority a low level of consumption of the glucose-alcohol solution. These groups were found only under conditions of systematic experimentation and the properties of each group became more marked in the course of these experiments.

Published
1978

8. Physiologo-biochemical bases of drug dependence treatment by electro-acupuncture.

Author

Sytinsky IA and Galebskaya LV

Subjects
Acetylcholine metabolism, Catecholamines metabolism, Electric Stimulation, Humans, Minerals metabolism, Nervous System metabolism, Proteins metabolism, Substance Withdrawal Syndrome physiopathology, Substance-Related Disorders metabolism, gamma-Aminobutyric Acid metabolism, Acupuncture Therapy methods, Substance-Related Disorders therapy
Published
1979
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9. Effects of benzene vapour on the gamma-aminobutyric acid (GABA) system in rat brain.

Author

Kadyrov GK, Saforov MI, and Sytinsky IA

Subjects
4-Aminobutyrate Transaminase metabolism, Animals, Aspartic Acid analysis, Brain enzymology, Brain Chemistry drug effects, Cerebellum analysis, Glutamate Decarboxylase metabolism, Glutamates analysis, In Vitro Techniques, Male, Pons analysis, Rats, gamma-Aminobutyric Acid analysis, Aminobutyrates metabolism, Benzene pharmacology, Brain metabolism, gamma-Aminobutyric Acid metabolism
Published
1975
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10. The gamma-aminobutyric acid (GABA) system in brain during acute and chronic ethanol intoxication.

Author

Sytinsky IA, Guzikov BM, Gomanko MV, Eremin VP, and Konovalova NN

Subjects
1-Propanol pharmacology, 4-Aminobutyrate Transaminase metabolism, Acute Disease, Animals, Brain enzymology, Butanols pharmacology, Chronic Disease, Ethanol administration & dosage, Glutamate Decarboxylase metabolism, Glutamates metabolism, Glutamine metabolism, Humans, Kidney enzymology, Liver enzymology, Male, Methanol pharmacology, Methods, Pentanols pharmacology, Rats, Swine, Alcoholic Intoxication metabolism, Aminobutyrates metabolism, Brain metabolism, gamma-Aminobutyric Acid metabolism
Published
1975
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15. A schema of the etiology of alcoholism as a pathological motivation. A working hypothesis involving the interplay of sociological, psychological and physiobiochemical factors on molecular, cellular and organosystemic levels.

Author

Sytinsky IA

Subjects
Alcoholism genetics, Alcoholism metabolism, Alcoholism physiopathology, Brain metabolism, Brain physiopathology, Drug Tolerance, Ethanol blood, Ethanol metabolism, Glucose metabolism, Humans, Models, Biological, Models, Psychological, Neurons metabolism, Alcoholism etiology, Motivation
Published
1973

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