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267 results on '"Suzumori, Nobuhiro"'

1. Prevalence of common aneuploidy in twin pregnancies

Author

Konishi, Akiko, Samura, Osamu, Muromoto, Jin, Okamoto, Yoko, Takahashi, Hironori, Kasai, Yasuyo, Ichikawa, Mayuko, Yamada, Naoki, Kato, Noriko, Sato, Hiroshi, Hamada, Hiromi, Nakanami, Naoyuki, Machi, Maya, Ichizuka, Kiyotake, Sunami, Rei, Tanaka, Toshitaka, Yonetani, Naoto, Kamei, Yoshimasa, Nagamatsu, Takeshi, Matsumoto, Mariko, Tairaku, Shinya, Fujiwara, Arisa, Nakamura, Hiroaki, Harada, Takashi, Watanabe, Takafumi, Sasaki, Shoko, Kawaguchi, Satoshi, Minami, Sawako, Ogawa, Masaki, Miura, Kiyonori, Suzumori, Nobuhiro, Kojima, Junya, Kotani, Tomomi, Sasaki, Rumi, Baba, Tsukasa, Toyofuku, Aya, Endo, Masayuki, Takeshita, Naoki, Taketani, Takeshi, Sase, Masakatsu, Matsubara, Keiichi, Hayata, Kei, Hamada, Yoshinobu, Egawa, Makiko, Kakinuma, Toshiyuki, Matsushima, Sachio, Kitagawa, Michihiro, Shiga, Tomomi, Kurashina, Ryuhei, Hamada, Hironori, Takagi, Hiroaki, Kondo, Akane, Miharu, Norio, Yamashita, Michiko, Horiya, Madoka, Morimoto, Keiji, Takahashi, Ken, Okamoto, Aikou, Sekizawa, Akihiko, and Sago, Haruhiko

Published
2022
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3. Retrospective details of false-positive and false-negative results in non-invasive prenatal testing for fetal trisomies 21, 18 and 13

Author

Suzumori, Nobuhiro, Sekizawa, Akihiko, Takeda, Eri, Samura, Osamu, Sasaki, Aiko, Akaishi, Rina, Wada, Seiji, Hamanoue, Haruka, Hirahara, Fumiki, Sawai, Hideaki, Nakamura, Hiroaki, Yamada, Takahiro, Miura, Kiyonori, Masuzaki, Hideaki, Nakayama, Setsuko, Kamei, Yoshimasa, Namba, Akira, Murotsuki, Jun, Yamaguchi, Masayuki, Tairaku, Shinya, Maeda, Kazuhisa, Kaji, Takashi, Okamoto, Yoko, Endo, Masayuki, Ogawa, Masaki, Kasai, Yasuyo, Ichizuka, Kiyotake, Yamada, Naoki, Ida, Akinori, Miharu, Norio, Kawaguchi, Satoshi, Hasuo, Yasuyuki, Okazaki, Tetsuya, Ichikawa, Mayuko, Izumi, Shunichiro, Kuno, Naohiko, Yotsumoto, Junko, Nishiyama, Miyuki, Shirato, Nahoko, Hirose, Tatsuko, and Sago, Haruhiko

Published
2021
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4. Impact of the new government‐involved noninvasive prenatal testing certification system on the awareness of pregnant women about noninvasive prenatal testing in Japan.

Author

Shirato, Nahoko, Sekizawa, Akihiko, Miyagami, Keiko, Sakamoto, Miwa, Yamada, Takahiro, Hirose, Tatsuko, Ikebukuro, Shin, Nakamura, Takeshi, Mizutani, Akane, Ikemoto, Mai, Izum, Mikiko, Seino, Hitomi, Yamada, Shigehito, Suzumori, Nobuhiro, Yoshihashi, Hiroshi, Samura, Osamu, Sawai, Hideaki, Sago, Haruhiko, and Okuyama, Torayuki

Subjects
RESEARCH funding, PREGNANT women, PRENATAL diagnosis, CERTIFICATION, DESCRIPTIVE statistics, SURVEYS, PROFESSIONAL employee training, PUBLIC administration, DATA analysis software, ACCESS to information
Abstract

Aim: In Japan, noninvasive prenatal testing (NIPT) has been performed by facilities accredited by the Japanese Society of Obstetrics and Gynecology since 2013. However, since 2016, with the implementation of NIPT, which can only be performed by blood sampling, non‐obstetricians have been involved in prenatal testing. Therefore, in July 2022, a new government‐involved NIPT certification system based on Health Sciences Council guidelines was introduced to ensure access to prenatal testing information for pregnant women. Methods: This survey was conducted in February 2023 and was the first survey after the certification system implementation. We conducted a web‐based survey of 1227 pregnant women and nursing mothers who underwent NIPT after July 2022 to evaluate their experiences. Results: Respondents were categorized by certification status as certified (C: 56%), non‐certified (non‐C: 23%), or uncertain (Q: 20%). The C group with a higher mean age at examination (35.0 ± 4.5 years) paid lower examination fees, received longer pre‐ and post‐examination explanations, and underwent more weekday examinations (80%) than the other groups. Most respondents, 67%, 48%, and 53% in the C, non‐C, and Q groups, respectively (p < 0.0001), stated that "NIPT needs to be regulated by the government or academic societies." The non‐C group was more likely to say, "Insufficient post‐test explanations at the laboratory made me more anxious," than the other groups when the testing results were non‐negative (p = 0.015). Conclusions: Despite government regulation, some pregnant women choose convenience over certified facilities, risking inadequate care. The government should ensure that NIPT is a safe option for all pregnant women. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Fetal cell-free DNA fraction in maternal plasma for the prediction of hypertensive disorders of pregnancy

Author

Suzumori, Nobuhiro, Sekizawa, Akihiko, Ebara, Takeshi, Samura, Osamu, Sasaki, Aiko, Akaishi, Rina, Wada, Seiji, Hamanoue, Haruka, Hirahara, Fumiki, Izumi, Haruna, Sawai, Hideaki, Nakamura, Hiroaki, Yamada, Takahiro, Miura, Kiyonori, Masuzaki, Hideaki, Yamashita, Takahiro, Okai, Takashi, Kamei, Yoshimasa, Namba, Akira, Murotsuki, Jun, Tanemoto, Tomohiro, Fukushima, Akimune, Haino, Kazufumi, Tairaku, Shinya, Matsubara, Keiichi, Maeda, Kazutoshi, Kaji, Takashi, Ogawa, Masanobu, Osada, Hisao, Nishizawa, Haruki, Okamoto, Yoko, Kanagawa, Takeshi, Kakigano, Aiko, Kitagawa, Michihiro, Ogawa, Masaki, Izumi, Shunichiro, Katagiri, Yukiko, Takeshita, Naoki, Kasai, Yasuyo, Naruse, Katsuhiko, Neki, Reiko, Masuyama, Hisashi, Hyodo, Maki, Kawano, Yukie, Ohba, Takashi, Ichizuka, Kiyotake, Nagamatsu, Takeshi, Watanabe, Atsushi, Shirato, Nahoko, Yotsumoto, Junko, Nishiyama, Miyuki, Hirose, Tatsuko, and Sago, Haruhiko

Published
2018
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20. Mutational analysis of FOXL2 p.C134W and expression of bone morphogenetic protein 2 in Japanese patients with granulosa cell tumor of ovary

Author

Oseto, Kumiko, Suzumori, Nobuhiro, Nishikawa, Ryutaro, Nishikawa, Hiroshi, Arakawa, Atsushi, Ozaki, Yasuhiko, Asai, Hidekazu, Kawai, Michiyasu, Mizuno, Kimio, Takahashi, Satoru, Shirai, Tomoyuki, Yamada-Namikawa, Chisato, Nakanishi, Makoto, Kajiyama, Hiroaki, Kikkawa, Fumitaka, and Sugiura-Ogasawara, Mayumi

Published
2014
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49. Trends of fetal chromosome analysis by amniocentesis before and after beginning of noninvasive prenatal testing: A single‐center experience in Japan.

Author

Goto, Shinobu, Suzumori, Nobuhiro, Kumagai, Kyoko, Otani, Ayano, Ogawa, Shino, Sawada, Yuki, Inuzuka, Saki, and Sugiura‐Ogasawara, Mayumi

Subjects
*BLOOD serum analysis, *CHROMOSOME analysis, *AMNIOCENTESIS, *PRENATAL diagnosis, *ACADEMIC medical centers, *CONFIDENCE intervals, *ANEUPLOIDY, *GENETIC testing, *RETROSPECTIVE studies, *KARYOTYPES, *HUMAN abnormalities, *CHROMOSOME abnormalities, *DESCRIPTIVE statistics, *MATERNAL age, *SECOND trimester of pregnancy, *GENETIC counseling, *FETAL ultrasonic imaging, *FETUS
Abstract

Aim: This study is to investigate the role of amniocentesis for prenatal diagnosis before and after the beginning of noninvasive prenatal testing (NIPT) in Japan. Methods: We performed a retrospective analysis of genetic amniocentesis at mid‐trimester (15–20 gestational weeks) for fetal karyotype analysis at Nagoya City University between April 2006 and March 2020. The indications, test results, and the detection rate of fetal abnormal karyotype were compared before (phase 1, P1) and after (phase 2, P2) beginning of NIPT at April 2013. Results: A total of 2458 (P1: 1132, P2: 1326) amniocentesis were enrolled in this study. The most frequent indication was advanced maternal age in both phases (P1: 78.2% %, P2: 81.1%). In P2, 110 patients (8.3%) received amniocentesis after positive or nonreportable NIPT results. Other indications were fetal abnormal findings by ultrasounds (P1: 15.4%, P2: 17.7%), abnormal maternal serum screening results (P1: 8.0%, P2: 10%), previous child with fetal chromosome aberration (P1: 6.5%, P2: 3.5%), and translocation of either partner (P1:1.5%, P2: 2.1%). The detection rate for fetal chromosomal aberrations including all indications was significantly increased in P2 (15.9%, 95% CI 14.0–18.0) as compared to P1 (9.0%, 7.4–10.8). However, if the indication was only advanced maternal age, the positive detection rate kept low in both phases (P1: 5.2%, 3.7–7.1, P2: 4.2%, 2.9–5.9). Conclusion: Since the initiation of NIPT, the detection rate of fetal chromosomal abnormalities was higher in this study, suggesting that amniocentesis cannot be strongly recommended for advanced maternal age alone. [ABSTRACT FROM AUTHOR]

Published
2021
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50. Evaluation of the clinical performance of noninvasive prenatal testing at a Japanese laboratory.

Author

Sasaki, Yuna, Yamada, Takahiro, Tanaka, Shiro, Sekizawa, Akihiko, Hirose, Tatsuko, Suzumori, Nobuhiro, Kaji, Takashi, Kawaguchi, Satoshi, Hasuo, Yasuyuki, Nishizawa, Haruki, Matsubara, Keiichi, Hamanoue, Haruka, Fukushima, Akimune, Endo, Masayuki, Yamaguchi, Masayuki, Kamei, Yoshimasa, Sawai, Hideaki, Miura, Kiyonori, Ogawa, Masaki, and Tairaku, Shinya

Subjects
DIAGNOSIS of Down syndrome, PATHOLOGICAL laboratories, PREDICTIVE tests, PRENATAL diagnosis, CONFIDENCE intervals, GENETIC testing, PREGNANT women, HIGH-risk pregnancy, GESTATIONAL age, CHROMOSOME abnormalities, MATERNAL age, DESCRIPTIVE statistics, TRISOMY 18 syndrome, GENETIC counseling
Abstract

Aim: We aimed to evaluate the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of noninvasive prenatal testing (NIPT) in high‐risk pregnant women. Methods: Pregnant women who underwent GeneTech NIPT, the most commonly used NIPT in Japan, between January 2015 and March 2019, at Japan NIPT Consortium medical sites were recruited for this study. The exclusion criteria were as follows: pregnant women with missing survey items, multiple pregnancy/vanishing twins, chromosomal abnormalities in the fetus other than the NIPT target disease, and nonreportable NIPT results. Sensitivity and specificity were calculated from the obtained data, and maternal age‐specific PPV and NPV were estimated. Results: Of the 45 504 cases, 44 263 cases fulfilling the study criteria were included. The mean maternal age and gestational weeks at the time of procedure were 38.5 years and 13.1 weeks, respectively. Sensitivities were 99.78% (95% confidence interval [95% CI]: 98.78–99.96), 99.12% (95% CI: 96.83–99.76), and 100% (95% CI: 88.30–100) for trisomies 21, 18, and 13, respectively. Specificities were more than 99.9% for trisomies 21, 18, and 13, respectively. Maternal age‐specific PPVs were more than 93%, 77%, and 43% at the age of 35 years for trisomies 21, 18, and 13, respectively. Conclusion: The GeneTech NIPT data showed high sensitivity and specificity in the detection of fetal trisomies 21, 18, and 13 in high‐risk pregnant women, and maternal age‐specific PPVs were obtained. These results could provide more accurate and improved information regarding NIPT for genetic counseling in Japan. [ABSTRACT FROM AUTHOR]

Published
2021
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