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Background and Objective: Topical tacrolimus has been shown to be beneficial in the treatment of oral lichen planus (OLP). However, long-term effects and its optimal application protocol with gradual reduction have not been studied. Accordingly, we analysed the clinical response of OLP to tacrolimus in our daily clinical practice with a focus on the optimal long-term therapeutic scheme., Methods: Retrospective analysis of all consecutive patients diagnosed with OLP and treated with topical tacrolimus (0.03% oral rinse) in a clinical setting between 2015 and 2020. The objective clinical response was measured by a 4-point scale (complete remission, major remission, partial remission and no response), and subjective impairment by a 3-point scale (severe, moderate and none)., Results: Fifty-seven patients (74% women; median age: 66 years) were included. Fifty-six (98%) patients had prior treatment with topical steroids. After introduction of tacrolimus, objective remission (major or complete) was reached by 28%, 62%, 87% and 97% of patients after 3, 6, 12 and 24 months respectively. Subjective remission was reported by 16%, 48%, 69% and 83% after 3, 6, 12 and 24 months of treatment respectively. The treatment frequency could be gradually reduced from initially twice daily to once daily or less in 28%, 61%, 78% and 87% after 3, 6, 12 and 24 months respectively; 41% of patients completely suspended the treatment at one point, but 67% of them experienced a relapse after a median time of 3.3 months. Four patients (7%) developed a squamous cell carcinoma (SCC) during the observation period. Otherwise, there were only few and minor side-effects., Conclusion: Topical tacrolimus can be an effective second-line therapy for OLP refractory to potent topical corticosteroids. The therapy frequency can often be reduced during the maintenance period. Both signs of clinical activity and subjective impairment should guide therapy. Regular follow-up is necessary to recognize possible SCC., (© 2022 The Authors. Journal of the European Academy of Dermatology and Venereology published by John Wiley & Sons Ltd on behalf of European Academy of Dermatology and Venereology.)

The purpose of this retrospective study was to evaluate risk factors for external root resorption (ERR) on maxillary second molars (MxM2) in association with impacted third molars (MxM3) using cone beam computed tomography (CBCT) scans. The angles between the axes of MxM2/MxM3 (inclination) were measured. Further, ERR on MxM2 was classified as absent, slight, moderate, or severe. Contact location between MxM3 and MxM2, the size of the dental follicle, type of impaction, root formation, and patient demographic characteristics were also assessed. Half of the 84 MxM2 showed ERR (slight 36.9%, moderate 6.0%, severe 7.1%). Patient age was a significant factor for the presence of ERR (P = 0.03). The inclination was also a relevant factor, with transverse MxM3 exhibiting the highest risk of ERR (P = 0.02). The cervical third (28.6%) showed a significantly lower risk percentage of ERR compared to the apical (73.7%) and middle thirds (60.6%) of the root (P = 0.004). Based on these findings, clinicians assessing the need for surgical removal should be able to selectively identify impacted MxM3 at risk of causing ERR on MxM2 early on, especially when the MxM3 is located in close contact with the apical and middle thirds of the MxM2 roots and has a transverse inclination., (Copyright © 2019 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.)

This randomized controlled trial (RCT) (ClinicalTrials.gov ID: NCT03001791) compared excisional biopsies of fibrous hyperplasia performed using a CO 2 laser (140Hz, 400μs, 33mJ), Er:YAG laser (35Hz, 297μs, 200mJ, air-water cooling), or scalpel (15c blade). Clinical parameters recorded were duration of the intervention, intraoperative bleeding, need for electrocauterization and/or suturing, postoperative side effects, complications, pain, and intake of analgesics. Histopathological linear measurements of the thermal damage zone were performed on the laser biopsies. Results showed that the duration of the intervention was significantly shorter for both lasers compared to the scalpel (P<0.001). Intraoperative bleeding occurred less frequently with the CO 2 laser (P<0.001). Additional electrocautery was used in 92% of Er:YAG laser interventions (P<0.001). Postsurgical complications, pain, and the intake of analgesics did not differ between the groups. The measured thermal damage zones differed significantly between the CO 2 laser (median of 72.6μm) and Er:YAG laser (30.9μm) (P<0.001). This RCT showed that CO 2 laser, Er:YAG laser, and scalpel are all adequate for excisional biopsies of small lesions in the oral mucosa. While patient postoperative morbidity is similar, the ideal instrument can be selected according to the surgical advantages preferred for the individual situation., (Copyright © 2019 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.)

External root resorption (ERR) affecting mandibular second molars (M2) may occur when the adjacent third molar (M3) is impacted in close proximity. This retrospective cohort study aimed to assess the presence, severity, and location of ERR on M2 due to M3 using cone beam computed tomography (CBCT) scans and to identify associated factors. The angle between the axis of M2 and M3 was measured. ERR on M2 was classified as absent, slight, moderate, or severe. The location of contact between M3 and M2, the size of the dental follicle, and patient demographic characteristics were recorded. A total of 433 patients with 640 M3 were included. A male predilection was found with regard to ERR (P=0.0004). ERR was identified on 31.9% of M2 and was slight in 30.2%, moderate in 1.4%, and severe in 0.3% of cases. The presence of ERR was associated with direct contact between M2 and M3 (P<0.0001), the angle between M2 and M3 (P<0.0001), the inclination of M3 (P=0.001), and the location of contact (P=0.0005). This study showed ERR to be a frequent finding. ERR is associated with a mesioangular position of M3 in more than one third of cases, and a proximity ≤0.5mm between M2 and M3 favours ERR., (Copyright © 2018. Published by Elsevier Ltd.)

Myelination requires extensive plasma membrane rearrangements, implying that molecules controlling membrane dynamics play prominent roles. The large GTPase dynamin 2 (DNM2) is a well-known regulator of membrane remodeling, membrane fission, and vesicular trafficking. Here, we genetically ablated Dnm2 in Schwann cells (SCs) and in oligodendrocytes of mice. Dnm2 deletion in developing SCs resulted in severely impaired axonal sorting and myelination onset. Induced Dnm2 deletion in adult SCs caused a rapidly-developing peripheral neuropathy with abundant demyelination. In both experimental settings, mutant SCs underwent prominent cell death, at least partially due to cytokinesis failure. Strikingly, when Dnm2 was deleted in adult SCs, non-recombined SCs still expressing DNM2 were able to remyelinate fast and efficiently, accompanied by neuropathy remission. These findings reveal a remarkable self-healing capability of peripheral nerves that are affected by SC loss. In the central nervous system, however, we found no major defects upon Dnm2 deletion in oligodendrocytes., Competing Interests: DG, MG, ET, CS, JG, JP, AO, GF, MM, LN, VS, VT, PS, CW, KT, US No competing interests declared, (© 2019, Gerber et al.)

In the developed world, the large birth cohorts of the so-called baby boomer generation have arrived in medical and dental practices. Often, elderly patients are 'young-old' baby boomers in whom partial edentulism is the predominant indication for implant therapy. However, the generation 85+ years of age represents a new challenge for the dental profession, as their lives are frequently dominated by dependency, multimorbidity and frailty. In geriatric implant dentistry, treatment planning is highly individualized, as interindividual differences become more pronounced with age. Nevertheless, there are four typical indications for implant therapy: (i) avoidance of removable partial prostheses; (ii) preservation of existing removable partial prostheses; (iii) stabilization of Kennedy Class I removable partial prostheses; and (iv) stabilization of complete prostheses. From a surgical point of view, two very important aspects must be considered when planning implant surgery in elderly patients: first, the consistent strive to minimize morbidity; and, second, the fact that coexisting medical risk factors are significantly more common in elderly patients. Modern three-dimensional cone beam computed tomography imaging is often indicated in order to plan minimally invasive implant surgery. Computer-assisted implant surgery might allow flapless implant surgery, which offers a low level of postoperative morbidity and a minimal risk of postsurgical bleeding. Short and reduced-diameter implants are now utilized much more often than a decade ago. Two-stage surgical procedures should be avoided in elderly patients. Implant restorations for elderly patients should be designed so that they can be modified to become low-maintenance prostheses, or even be removed, as a strategy to facilitate oral hygiene and comfort in the final stage of life., (© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)