7 results on '"Sung Hak Kang"'
Search Results
2. Arterial Injury Associated with Tension-Free Vaginal Tapes-SECUR Procedure Successfully Treated by Radiological Embolization
- Author
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Yong Seok Lee, Joon Ho Lee, Sung Hak Kang, Tae Seung Shin, Yun Seok Jung, and Chang Hee Han
- Subjects
medicine.medical_specialty ,Tvt secur ,Urology ,medicine.medical_treatment ,Urinary incontinence ,Case Report ,lcsh:RC870-923 ,Embolization ,medicine.artery ,medicine ,Internal pudendal artery ,Arterial injury ,medicine.diagnostic_test ,business.industry ,lcsh:Diseases of the genitourinary system. Urology ,Surgery ,Neurology ,Radiological weapon ,Angiography ,Neurology (clinical) ,medicine.symptom ,Complication ,business ,TVT-SECUR - Abstract
Various postoperative complications have been reported after the use of tension-free vaginal tapes (TVT). The transobturator approach was introduced to minimize the potential complications. The next generation of recently introduced TVT-SECUR is intended to minimize the incidence of complications. Herein we report a case of internal pudendal artery injury sustained during this procedure that was successfully treated by radiological embolization. Angiography with vessel embolization, when available, should be considered when the arterial injury is suspected.
- Published
- 2010
3. The alpha subunit of Go modulates cell proliferation and differentiation through interactions with Necdin
- Author
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Sungho Ghil, Sung-Hak Kang, Hyunhee Ju, Sung-Soo Kim, and Sujin Lee
- Subjects
DNA, Complementary ,Cellular differentiation ,Two-hybrid screening ,Gi alpha subunit ,Nerve Tissue Proteins ,Biology ,GTP-Binding Protein alpha Subunits, Gi-Go ,Biochemistry ,Cell Line ,Mice ,Receptor, Cannabinoid, CB1 ,Heterotrimeric G protein ,Two-Hybrid System Techniques ,Animals ,Humans ,Nuclear protein ,Molecular Biology ,Cannabinoid ,G alpha subunit ,G protein-coupled receptor ,Cell Proliferation ,Research ,Yeast two-hybrid ,Brain ,Nuclear Proteins ,Cell Differentiation ,Cell Biology ,Cell biology ,E2F1 ,G-protein coupled receptor ,Signal transduction - Abstract
Background Heterotrimeric GTP-binding proteins (G-proteins) play an important role in mediating signal transduction generated by neurotransmitters or hormones. Go, a member of the Gi/Go subfamily, is the most abundant G-protein found in the brain. Recently, the alpha subunit of Go (Gαo) was characterized as an inducer of neuronal differentiation. However, its underlying molecular mechanisms have remained unclear to date, since the downstream effectors of Gαo are ambiguous. Results A neurally differentiated embryonal carcinoma-derived protein (Necdin) was isolated as an interacting partner for Gαo from a mouse brain cDNA library using yeast two-hybrid screening. Interactions between the proteins were confirmed with several affinity binding assays, both in vitro and in vivo. Necdin interacted directly and preferentially with activated Gαo, compared to wild-type protein. Interestingly, Gαo did not interact with Gαi, despite high sequence homology between the two proteins. We subsequently analyzed whether Gαo modulates the cellular activities of Necdin. Notably, expression of Gαo significantly augmented Necdin-mediated cellular responses, such as proliferation and differentiation. Moreover, activation of type 1 cannabinoid receptor (CB1R), a Gi/oα-coupled receptor, augmented cell growth suppression, which was mediated by Gαo and Necdin in U87MG cells containing CB1R, Gαo, and Necdin as normal components. Conclusions These results collectively suggest that Necdin is a candidate downstream effector for Gαo. Our findings provide novel insights into the cellular roles of Gαo and its coupled receptor.
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- 2014
4. Protective effects of cranberries on infection-induced oxidative renal damage in a rabbit model of vesico-ureteric reflux.
- Author
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Chang Hee Han, Soo Hwan Kim, Sung Hak Kang, Ok Ran Shin, Hae Kyung Lee, Hee Jeong Kim, and Yong-Hyun Cho
- Subjects
KIDNEYS ,ABDOMEN ,URINARY organs ,SURGERY ,ESCHERICHIA - Abstract
OBJECTIVE To evaluate the protective effects of cranberry fruit, which have known antioxidant effects, on infection-induced oxidative renal damage in a rabbit model of vesico-ureteric reflux (VUR). MATERIALS AND METHODS In all, 36 New Zealand male rabbits were divided into five groups, with a sham operation in four rabbits serving as the control (group 1). To create unilateral VUR the roof of the left intravesical ureter was incised, and VUR confirmed 2 weeks after surgery. In all, 32 rabbits with VUR were divided into four groups; 2, VUR alone (with sterile urine); 3, a group infected with Escherichia coli; 4, with intravesical E. coli instillation but fed cranberries; and 5, intravesical E. coli instillation plus an intraperitoneal injection with melatonin group. At 3 weeks after surgery the rabbits were killed, the kidneys obtained and examined histopathologically to evaluate inflammation, fibrosis and tubular changes. Oxidative renal damage was evaluated by measuring malondialdehyde in the renal tissue. RESULTS Grossly, the refluxing kidney was larger than the contralateral normal kidney, and the refluxing ureter was dilated and tortuous. Microscopy of tissues from the kidneys in group 3 showed apparent periglomerular mononuclear cell infiltration, tubular dilatation and atrophy, and interstitial fibrosis. The kidneys from groups 2, 4 and 5 showed mild mononuclear cell infiltration with no interstitial fibrosis. The level of malondialdehyde in the kidneys of group 3 was significantly higher than that in group 2, 4 and 5 ( P < 0.05); the level in groups 4 and 5 did not differ significantly from that in group 2. CONCLUSIONS This study shows that cranberries have an anti-inflammatory effect through their antioxidant function and might prevent infection-induced oxidative renal damage. Thus, clinically cranberries might be used as a beneficial adjuvant treatment to prevent damage due to pyelonephritis in children with VUR. [ABSTRACT FROM AUTHOR]
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- 2007
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5. Upregulation of Thymidine Phosphorylase in Chronic Glomerulonephritis and Its Role in Tubulointerstitial Injury.
- Author
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Eun-Hui Wang, Yong Bok Goh, In Sung Moon, Cho Hyun Park, Kweon-Heang Lee, Sung Hak Kang, Chang Suk Kang, and Yeong-Jin Choi
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THYMIDINE ,GLOMERULONEPHRITIS ,PHOSPHORYLASES ,BLOOD vessels ,NEOVASCULARIZATION ,KIDNEY diseases ,FIBROSIS - Abstract
Chronic tubulointerstitial injury (CTI), commonly a sequel to chronic glomerulonephritis (CGN), is associated with the proliferation of new blood vessels. Angiogenesis is an essential process in chronic inflammation, and is controlled by a number of angiogenic factors including thymidine phosphorylase (TP). Knowledge of TP in renal disease is still rudimentary, and its role in CGN has not been explored. We analyzed the expression of TP by RTPCR, immunohistology and in situ hybridization in 20 human kidneys with CGN. To evaluate the degree of angiogenesis, we counted the microvessel density (MVD). MVD was significantly higher in all categories of CGN, between 19.7 ± 7.7 and 58.9 ± 7.5, compared to control value, 12.7 ± 5.0 (p< 0.05). MVD was increased in areas of abundant mononuclear cell infiltration with minimal interstitial fibrosis, and decreased or absent in areas of marked fibrosis. There was a significant correlation between MVD and interstitial fibrosis (p < 0.0001). TP mRNA was upregulated for all categories of CGN. TP was strongly expressed by mononuclear inflammatory cells and in most atrophic tubules. Each MVD and interstitial volume was significantly correlated with both the number of TP+ mononuclear cells and TP+ tubular cells, respectively (p < 0.0001). We have demonstrated an upregulation of TP and increase in MVD in areas of CTI in a variety of CGN. The up-regulation of TP may contribute to angiogenesis, which may play a critical role in the progression of interstitial fibrosis in CGN. Copyright © 2006 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
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- 2006
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6. Synergistic effect between catechin and ciprofloxacin on chronic bacterial prostatitis rat model.
- Author
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Yong Seok Lee, Chang Hee Han, Sung Hak Kang, Seung-Ju Lee, Sae Woong Kim, Ok Ran Shin, Young-Chul Sim, Sang-Jun Lee, and Yong-Hyun Cho
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PROSTATITIS ,CATECHIN ,CIPROFLOXACIN ,BACTERIAL diseases ,PROSTATE diseases ,ANTIBACTERIAL agents - Abstract
Chronic bacterial prostatitis (CBP) is the most common urological disease in adult men. Antibiotic therapy is the gold standard of treatment. However, long-term therapy resulted in many side-effects and bacterial resistance. Because of these reasons, we need new treatment modality that could replace traditional antibiotic therapy. Catechin, an extract of green tea, has antimicrobial effect against various bacteria and synergy effect to antibiotics. We evaluate the synergistic effects of catechin on the treatment of CBP in an animal model.An experimental CBP model was induced in 70 male Wistar rats by instillation of 0.2 mL bacterial suspension (E-coli Z17, O2:K1:H-) containing 1 × 108 CFU/mL into the prostatic urethra. Microbiologically and histologically proven CBP model was demonstrated in 58.6% (41 of 70) of the rats after 4 weeks of bacterial instillation. The 41 rats demonstrating CBP were randomly divided into four groups; the control, catechin, ciprofloxacin and catechin with ciprofloxacin groups. All drug treatments were conducted over a period of 2 weeks. After treatment, the results were analyzed with microbiological cultures and histological findings of the prostate and urine samples to compare each group.Microbiological cultures and histological findings of the prostate and urine samples demonstrated reduced bacterial growth and improved inflammatory responses in all three experimental groups compared with the control group. The catechin group showed coherent trends of decrease in bacterial growth and improvements in prostatic inflammation compared with the control group, but not to a statistically significant degree (P > 0.05). However, the ciprofloxacin and catechin with ciprofloxacin groups showed statistically significant decreases in bacterial growth and improvements in prostatic inflammation compared with the control group (P < 0.05). The catechin with ciprofloxacin group showed a statistically significant decrease in bacterial growth and improvements in prostatic inflammation compared with the ciprofloxacin group (P < 0.05).These results suggest that catechin may be an effective material in CBP treatment. Particularly, combination treatment of catechin and ciprofloxacin has synergistic effect. Therefore, we suggest that the combination of catechin and ciprofloxacin may be effective in treating CBP with a higher success rate. [ABSTRACT FROM AUTHOR]
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- 2005
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7. Protective effects of cranberry on infection-induced oxidative renal damage in vesicoureteral reflux in a rabbit model
- Author
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Chang Hee HAN, Soo Hwan KIM, Sung Hak KANG and Yong Hyun CHO
- Published
- 2007
- Full Text
- View/download PDF
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