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2. Introducing the CTA concept

Author

Acharya, B.S., Actis, M., Aghajani, T., Agnetta, G., Aguilar, J., Aharonian, F., Ajello, M., Akhperjanian, A., Alcubierre, M., Aleksić, J., Alfaro, R., Aliu, E., Allafort, A.J., Allan, D., Allekotte, I., Amato, E., Anderson, J., Angüner, E.O., Antonelli, L.A., Antoranz, P., Aravantinos, A., Arlen, T., Armstrong, T., Arnaldi, H., Arrabito, L., Asano, K., Ashton, T., Asorey, H.G., Awane, Y., Baba, H., Babic, A., Baby, N., Bähr, J., Bais, A., Baixeras, C., Bajtlik, S., Balbo, M., Balis, D., Balkowski, C., Bamba, A., Bandiera, R., Barber, A., Barbier, C., Barceló, M., Barnacka, A., Barnstedt, J., Barres de Almeida, U., Barrio, J.A., Basili, A., Basso, S., Bastieri, D., Bauer, C., Baushev, A., Becerra, J., Becherini, Y., Bechtol, K.C., Becker Tjus, J., Beckmann, V., Bednarek, W., Behera, B., Belluso, M., Benbow, W., Berdugo, J., Berger, K., Bernard, F., Bernardino, T., Bernlöhr, K., Bhat, N., Bhattacharyya, S., Bigongiari, C., Biland, A., Billotta, S., Bird, T., Birsin, E., Bissaldi, E., Biteau, J., Bitossi, M., Blake, S., Blanch Bigas, O., Blasi, P., Bobkov, A., Boccone, V., Boettcher, M., Bogacz, L., Bogart, J., Bogdan, M., Boisson, C., Boix Gargallo, J., Bolmont, J., Bonanno, G., Bonardi, A., Bonev, T., Bonifacio, P., Bonnoli, G., Bordas, P., Borgland, A., Borkowski, J., Bose, R., Botner, O., Bottani, A., Bouchet, L., Bourgeat, M., Boutonnet, C., Bouvier, A., Brau-Nogué, S., Braun, I., Bretz, T., Briggs, M., Bringmann, T., Brook, P., Brun, P., Brunetti, L., Buanes, T., Buckley, J., Buehler, R., Bugaev, V., Bulgarelli, A., Bulik, T., Busetto, G., Buson, S., Byrum, K., Cailles, M., Cameron, R., Camprecios, J., Canestrari, R., Cantu, S., Capalbi, M., Caraveo, P., Carmona, E., Carosi, A., Carr, J., Carton, P.-H., Casanova, S., Casiraghi, M., Catalano, O., Cavazzani, S., Cazaux, S., Cerruti, M., Chabanne, E., Chadwick, P., Champion, C., Chen, A., Chiang, J., Chiappetti, L., Chikawa, M., Chitnis, V.R., Chollet, F., Chudoba, J., Cieślar, M., Cillis, A., Cohen-Tanugi, J., Colafrancesco, S., Colin, P., Colome, J., Colonges, S., Compin, M., Conconi, P., Conforti, V., Connaughton, V., Conrad, J., Contreras, J.L., Coppi, P., Corona, P., Corti, D., Cortina, J., Cossio, L., Costantini, H., Cotter, G., Courty, B., Couturier, S., Covino, S., Crimi, G., Criswell, S.J., Croston, J., Cusumano, G., Dafonseca, M., Dale, O., Daniel, M., Darling, J., Davids, I., Dazzi, F., De Angelis, A., De Caprio, V., De Frondat, F., de Gouveia Dal Pino, E.M., de la Calle, I., De La Vega, G.A., de los Reyes Lopez, R., De Lotto, B., De Luca, A., de Mello Neto, J.R.T., de Naurois, M., de Oliveira, Y., de Oña Wilhelmi, E., de Souza, V., Decerprit, G., Decock, G., Deil, C., Delagnes, E., Deleglise, G., Delgado, C., Della Volpe, D., Demange, P., Depaola, G., Dettlaff, A., Di Paola, A., Di Pierro, F., Díaz, C., Dick, J., Dickherber, R., Dickinson, H., Diez-Blanco, V., Digel, S., Dimitrov, D., Disset, G., Djannati-Ataï, A., Doert, M., Dohmke, M., Domainko, W., Dominis Prester, D., Donat, A., Dorner, D., Doro, M., Dournaux, J.-L., Drake, G., Dravins, D., Drury, L., Dubois, F., Dubois, R., Dubus, G., Dufour, C., Dumas, D., Dumm, J., Durand, D., Dyks, J., Dyrda, M., Ebr, J., Edy, E., Egberts, K., Eger, P., Einecke, S., Eleftheriadis, C., Elles, S., Emmanoulopoulos, D., Engelhaupt, D., Enomoto, R., Ernenwein, J.-P., Errando, M., Etchegoyen, A., Evans, P., Falcone, A., Fantinel, D., Farakos, K., Farnier, C., Fasola, G., Favill, B., Fede, E., Federici, S., Fegan, S., Feinstein, F., Ferenc, D., Ferrando, P., Fesquet, M., Fiasson, A., Fillin-Martino, E., Fink, D., Finley, C., Finley, J.P., Fiorini, M., Firpo Curcoll, R., Flores, H., Florin, D., Focke, W., Föhr, C., Fokitis, E., Font, L., Fontaine, G., Fornasa, M., Förster, A., Fortson, L., Fouque, N., Franckowiak, A., Fransson, C., Fraser, G., Frei, R., Albuquerque, I.F.M., Fresnillo, L., Fruck, C., Fujita, Y., Fukazawa, Y., Fukui, Y., Funk, S., Gäbele, W., Gabici, S., Gabriele, R., Gadola, A., Galante, N., Gall, D., Gallant, Y., Gámez-García, J., García, B., Garcia López, R., Gardiol, D., Garrido, D., Garrido, L., Gascon, D., Gaug, M., Gaweda, J., Gebremedhin, L., Geffroy, N., Gerard, L., Ghedina, A., Ghigo, M., Giannakaki, E., Gianotti, F., Giarrusso, S., Giavitto, G., Giebels, B., Gika, V., Giommi, P., Girard, N., Giro, E., Giuliani, A., Glanzman, T., Glicenstein, J.-F., Godinovic, N., Golev, V., Gomez Berisso, M., Gómez-Ortega, J., Gonzalez, M.M., González, A., González, F., González Muñoz, A., Gothe, K.S., Gougerot, M., Graciani, R., Grandi, P., Grañena, F., Granot, J., Grasseau, G., Gredig, R., Green, A., Greenshaw, T., Grégoire, T., Grimm, O., Grube, J., Grudzinska, M., Gruev, V., Grünewald, S., Grygorczuk, J., Guarino, V., Gunji, S., Gyuk, G., Hadasch, D., Hagiwara, R., Hahn, J., Hakansson, N., Hallgren, A., Hamer Heras, N., Hara, S., Hardcastle, M.J., Harris, J., Hassan, T., Hatanaka, K., Haubold, T., Haupt, A., Hayakawa, T., Hayashida, M., Heller, R., Henault, F., Henri, G., Hermann, G., Hermel, R., Herrero, A., Hidaka, N., Hinton, J., Hoffmann, D., Hofmann, W., Hofverberg, P., Holder, J., Horns, D., Horville, D., Houles, J., Hrabovsky, M., Hrupec, D., Huan, H., Huber, B., Huet, J.-M., Hughes, G., Humensky, T.B., Huovelin, J., Ibarra, A., Illa, J.M., Impiombato, D., Incorvaia, S., Inoue, S., Inoue, Y., Ioka, K., Ismailova, E., Jablonski, C., Jacholkowska, A., Jamrozy, M., Janiak, M., Jean, P., Jeanney, C., Jimenez, J.J., Jogler, T., Johnson, T., Journet, L., Juffroy, C., Jung, I., Kaaret, P., Kabuki, S., Kagaya, M., Kakuwa, J., Kalkuhl, C., Kankanyan, R., Karastergiou, A., Kärcher, K., Karczewski, M., Karkar, S., Kasperek, J., Kastana, D., Katagiri, H., Kataoka, J., Katarzyński, K., Katz, U., Kawanaka, N., Kellner-Leidel, B., Kelly, H., Kendziorra, E., Khélifi, B., Kieda, D.B., Kifune, T., Kihm, T., Kishimoto, T., Kitamoto, K., Kluźniak, W., Knapic, C., Knapp, J., Knödlseder, J., Köck, F., Kocot, J., Kodani, K., Köhne, J.-H., Kohri, K., Kokkotas, K., Kolitzus, D., Komin, N., Kominis, I., Konno, Y., Köppel, H., Korohoda, P., Kosack, K., Koss, G., Kossakowski, R., Kostka, P., Koul, R., Kowal, G., Koyama, S., Kozioł, J., Krähenbühl, T., Krause, J., Krawzcynski, H., Krennrich, F., Krepps, A., Kretzschmann, A., Krobot, R., Krueger, P., Kubo, H., Kudryavtsev, V.A., Kushida, J., Kuznetsov, A., La Barbera, A., La Palombara, N., La Parola, V., La Rosa, G., Lacombe, K., Lamanna, G., Lande, J., Languignon, D., Lapington, J., Laporte, P., Lavalley, C., Le Flour, T., Le Padellec, A., Lee, S.-H., Lee, W.H., Leigui de Oliveira, M.A., Lelas, D., Lenain, J.-P., Leopold, D.J., Lerch, T., Lessio, L., Lieunard, B., Lindfors, E., Liolios, A., Lipniacka, A., Lockart, H., Lohse, T., Lombardi, S., Lopatin, A., Lopez, M., López-Coto, R., López-Oramas, A., Lorca, A., Lorenz, E., Lubinski, P., Lucarelli, F., Lüdecke, H., Ludwin, J., Luque-Escamilla, P.L., Lustermann, W., Luz, O., Lyard, E., Maccarone, M.C., Maccarone, T.J., Madejski, G.M., Madhavan, A., Mahabir, M., Maier, G., Majumdar, P., Malaguti, G., Maltezos, S., Manalaysay, A., Mancilla, A., Mandat, D., Maneva, G., Mangano, A., Manigot, P., Mannheim, K., Manthos, I., Maragos, N., Marcowith, A., Mariotti, M., Marisaldi, M., Markoff, S., Marszałek, A., Martens, C., Martí, J., Martin, J.-M., Martin, P., Martínez, G., Martínez, F., Martínez, M., Masserot, A., Mastichiadis, A., Mathieu, A., Matsumoto, H., Mattana, F., Mattiazzo, S., Maurin, G., Maxfield, S., Maya, J., Mazin, D., Mc Comb, L., McCubbin, N., McHardy, I., McKay, R., Medina, C., Melioli, C., Melkumyan, D., Mereghetti, S., Mertsch, P., Meucci, M., Michałowski, J., Micolon, P., Mihailidis, A., Mineo, T., Minuti, M., Mirabal, N., Mirabel, F., Miranda, J.M., Mirzoyan, R., Mizuno, T., Moal, B., Moderski, R., Mognet, I., Molinari, E., Molinaro, M., Montaruli, T., Monteiro, I., Moore, P., Moralejo Olaizola, A., Mordalska, M., Morello, C., Mori, K., Mottez, F., Moudden, Y., Moulin, E., Mrusek, I., Mukherjee, R., Munar-Adrover, P., Muraishi, H., Murase, K., Murphy, A., Nagataki, S., Naito, T., Nakajima, D., Nakamori, T., Nakayama, K., Naumann, C., Naumann, D., Naumann-Godo, M., Nayman, P., Nedbal, D., Neise, D., Nellen, L., Neustroev, V., Neyroud, N., Nicastro, L., Nicolau-Kukliński, J., Niedźwiecki, A., Niemiec, J., Nieto, D., Nikolaidis, A., Nishijima, K., Nolan, S., Northrop, R., Nosek, D., Nowak, N., Nozato, A., O’Brien, P., Ohira, Y., Ohishi, M., Ohm, S., Ohoka, H., Okuda, T., Okumura, A., Olive, J.-F., Ong, R.A., Orito, R., Orr, M., Osborne, J., Ostrowski, M., Otero, L.A., Otte, N., Ovcharov, E., Oya, I., Ozieblo, A., Padilla, L., Paiano, S., Paillot, D., Paizis, A., Palanque, S., Palatka, M., Pallota, J., Panagiotidis, K., Panazol, J.-L., Paneque, D., Panter, M., Paoletti, R., Papayannis, A., Papyan, G., Paredes, J.M., Pareschi, G., Parks, G., Parraud, J.-M., Parsons, D., Paz Arribas, M., Pech, M., Pedaletti, G., Pelassa, V., Pelat, D., Perez, M.d.C., Persic, M., Petrucci, P.-O., Peyaud, B., Pichel, A., Pita, S., Pizzolato, F., Platos, Ł., Platzer, R., Pogosyan, L., Pohl, M., Pojmanski, G., Ponz, J.D., Potter, W., Poutanen, J., Prandini, E., Prast, J., Preece, R., Profeti, F., Prokoph, H., Prouza, M., Proyetti, M., Puerto-Gimenez, I., Pühlhofer, G., Puljak, I., Punch, M., Pyzioł, R., Quel, E.J., Quinn, J., Quirrenbach, A., Racero, E., Rajda, P.J., Ramon, P., Rando, R., Rannot, R.C., Rataj, M., Raue, M., Reardon, P., Reimann, O., Reimer, A., Reimer, O., Reitberger, K., Renaud, M., Renner, S., Reville, B., Rhode, W., Ribó, M., Ribordy, M., Richer, M.G., Rico, J., Ridky, J., Rieger, F., Ringegni, P., Ripken, J., Ristori, P.R., Riviére, A., Rivoire, S., Rob, L., Roeser, U., Rohlfs, R., Rojas, G., Romano, P., Romaszkan, W., Romero, G.E., Rosen, S., Rosier Lees, S., Ross, D., Rouaix, G., Rousselle, J., Rousselle, S., Rovero, A.C., Roy, F., Royer, S., Rudak, B., Rulten, C., Rupiński, M., Russo, F., Ryde, F., Sacco, B., Saemann, E.O., Saggion, A., Sahakian, V., Saito, K., Saito, T., Saito, Y., Sakaki, N., Sakonaka, R., Salini, A., Sanchez, F., Sanchez-Conde, M., Sandoval, A., Sandaker, H., Sant’Ambrogio, E., Santangelo, A., Santos, E.M., Sanuy, A., Sapozhnikov, L., Sarkar, S., Sartore, N., Sasaki, H., Satalecka, K., Sawada, M., Scalzotto, V., Scapin, V., Scarcioffolo, M., Schafer, J., Schanz, T., Schlenstedt, S., Schlickeiser, R., Schmidt, T., Schmoll, J., Schovanek, P., Schroedter, M., Schultz, C., Schultze, J., Schulz, A., Schure, K., Schwab, T., Schwanke, U., Schwarz, J., Schwarzburg, S., Schweizer, T., Schwemmer, S., Segreto, A., Seiradakis, J.-H., Sembroski, G.H., Seweryn, K., Sharma, M., Shayduk, M., Shellard, R.C., Shi, J., Shibata, T., Shibuya, A., Shum, E., Sidoli, L., Sidz, M., Sieiro, J., Sikora, M., Silk, J., Sillanpää, A., Singh, B.B., Sitarek, J., Skole, C., Smareglia, R., Smith, A., Smith, D., Smith, J., Smith, N., Sobczyńska, D., Sol, H., Sottile, G., Sowiński, M., Spanier, F., Spiga, D., Spyrou, S., Stamatescu, V., Stamerra, A., Starling, R., Stawarz, Ł., Steenkamp, R., Stegmann, C., Steiner, S., Stergioulas, N., Sternberger, R., Sterzel, M., Stinzing, F., Stodulski, M., Straumann, U., Strazzeri, E., Stringhetti, L., Suarez, A., Suchenek, M., Sugawara, R., Sulanke, K.-H., Sun, S., Supanitsky, A.D., Suric, T., Sutcliffe, P., Sykes, J., Szanecki, M., Szepieniec, T., Szostek, A., Tagliaferri, G., Tajima, H., Takahashi, H., Takahashi, K., Takalo, L., Takami, H., Talbot, G., Tammi, J., Tanaka, M., Tanaka, S., Tasan, J., Tavani, M., Tavernet, J.-P., Tejedor, L.A., Telezhinsky, I., Temnikov, P., Tenzer, C., Terada, Y., Terrier, R., Teshima, M., Testa, V., Tezier, D., Thuermann, D., Tibaldo, L., Tibolla, O., Tiengo, A., Tluczykont, M., Todero Peixoto, C.J., Tokanai, F., Tokarz, M., Toma, K., Torii, K., Tornikoski, M., Torres, D.F., Torres, M., Tosti, G., Totani, T., Toussenel, F., Tovmassian, G., Travnicek, P., Trifoglio, M., Troyano, I., Tsinganos, K., Ueno, H., Umehara, K., Upadhya, S.S., Usher, T., Uslenghi, M., Valdes-Galicia, J.F., Vallania, P., Vallejo, G., van Driel, W., van Eldik, C., Vandenbrouke, J., Vanderwalt, J., Vankov, H., Vasileiadis, G., Vassiliev, V., Veberic, D., Vegas, I., Vercellone, S., Vergani, S., Veyssiére, C., Vialle, J.P., Viana, A., Videla, M., Vincent, P., Vincent, S., Vink, J., Vlahakis, N., Vlahos, L., Vogler, P., Vollhardt, A., von Gunten, H.-P., Vorobiov, S., Vuerli, C., Waegebaert, V., Wagner, R., Wagner, R.G., Wagner, S., Wakely, S.P., Walter, R., Walther, T., Warda, K., Warwick, R., Wawer, P., Wawrzaszek, R., Webb, N., Wegner, P., Weinstein, A., Weitzel, Q., Welsing, R., Werner, M., Wetteskind, H., White, R., Wierzcholska, A., Wiesand, S., Wilkinson, M., Williams, D.A., Willingale, R., Winiarski, K., Wischnewski, R., Wiśniewski, Ł., Wood, M., Wörnlein, A., Xiong, Q., Yadav, K.K., Yamamoto, H., Yamamoto, T., Yamazaki, R., Yanagita, S., Yebras, J.M., Yelos, D., Yoshida, A., Yoshida, T., Yoshikoshi, T., Zabalza, V., Zacharias, M., Zajczyk, A., Zanin, R., Zdziarski, A., Zech, A., Zhao, A., Zhou, X., Ziętara, K., Ziolkowski, J., Ziółkowski, P., Zitelli, V., Zurbach, C., and Żychowski, P.

Published
2013
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3. Design concepts for the Cherenkov Telescope Array CTA: an advanced facility for ground-based high-energy gamma-ray astronomy

Author

Actis, M., Agnetta, G., Aharonian, F., Akhperjanian, A., Aleksić, J., Aliu, E., Allan, D., Allekotte, I., Antico, F., Antonelli, L. A., Antoranz, P., Aravantinos, A., Arlen, T., Arnaldi, H., Artmann, S., Asano, K., Asorey, H., Bähr, J., Bais, A., Baixeras, C., Bajtlik, S., Balis, D., Bamba, A., Barbier, C., Barceló, M., Barnacka, A., Barnstedt, J., Barres de Almeida, U., Barrio, J. A., Basso, S., Bastieri, D., Bauer, C., Becerra, J., Becherini, Y., Bechtol, K., Becker, J., Beckmann, V., Bednarek, W., Behera, B., Beilicke, M., Belluso, M., Benallou, M., Benbow, W., Berdugo, J., Berger, K., Bernardino, T., Bernlöhr, K., Biland, A., Billotta, S., Bird, T., Birsin, E., Bissaldi, E., Blake, S., Blanch, O., Bobkov, A. A., Bogacz, L., Bogdan, M., Boisson, C., Boix, J., Bolmont, J., Bonanno, G., Bonardi, A., Bonev, T., Borkowski, J., Botner, O., Bottani, A., Bourgeat, M., Boutonnet, C., Bouvier, A., Brau-Nogué, S., Braun, I., Bretz, T., Briggs, M. S., Brun, P., Brunetti, L., Buckley, J. H., Bugaev, V., Bühler, R., Bulik, T., Busetto, G., Buson, S., Byrum, K., Cailles, M., Cameron, R., Canestrari, R., Cantu, S., Carmona, E., Carosi, A., Carr, J., Carton, P. H., Casiraghi, M., Castarede, H., Catalano, O., Cavazzani, S., Cazaux, S., Cerruti, B., Cerruti, M., Chadwick, P. M., Chiang, J., Chikawa, M., Cieślar, M., Ciesielska, M., Cillis, A., Clerc, C., Colin, P., Colomé, J., Compin, M., Conconi, P., Connaughton, V., Conrad, J., Contreras, J. L., Coppi, P., Corlier, M., Corona, P., Corpace, O., Corti, D., Cortina, J., Costantini, H., Cotter, G., Courty, B., Couturier, S., Covino, S., Croston, J., Cusumano, G., Daniel, M. K., Dazzi, F., Angelis, A. de, de Cea del Pozo, E., de Gouveia Dal Pino, E. M., de Jager, O., de la Calle Pérez, I., De La Vega, G., De Lotto, B., de Naurois, M., de Oña Wilhelmi, E., de Souza, V., Decerprit, B., Deil, C., Delagnes, E., Deleglise, G., Delgado, C., Dettlaff, T., Di Paolo, A., Di Pierro, F., Díaz, C., Dick, J., Dickinson, H., Digel, S. W., Dimitrov, D., Disset, G., Djannati-Ataï, A., Doert, M., Domainko, W., Dorner, D., Doro, M., Dournaux, J.-L., Dravins, D., Drury, L., Dubois, F., Dubois, R., Dubus, G., Dufour, C., Durand, D., Dyks, J., Dyrda, M., Edy, E., Egberts, K., Eleftheriadis, C., Elles, S., Emmanoulopoulos, D., Enomoto, R., Ernenwein, J.-P., Errando, M., Etchegoyen, A., Falcone, A. D., Farakos, K., Farnier, C., Federici, S., Feinstein, F., Ferenc, D., Fillin-Martino, E., Fink, D., Finley, C., Finley, J. P., Firpo, R., Florin, D., Föhr, C., Fokitis, E., Font, Ll., Fontaine, G., Fontana, A., Förster, A., Fortson, L., Fouque, N., Fransson, C., Fraser, G. W., Fresnillo, L., Fruck, C., Fujita, Y., Fukazawa, Y., Funk, S., Gäbele, W., Gabici, S., Gadola, A., Galante, N., Gallant, Y., García, B., García López, R. J., Garrido, D., Garrido, L., Gascón, D., Gasq, C., Gaug, M., Gaweda, J., Geffroy, N., Ghag, C., Ghedina, A., Ghigo, M., Gianakaki, E., Giarrusso, S., Giavitto, G., Giebels, B., Giro, E., Giubilato, P., Glanzman, T., Glicenstein, J.-F., Gochna, M., Golev, V., Gómez Berisso, M., González, A., González, F., Grañena, F., Graciani, R., Granot, J., Gredig, R., Green, A., Greenshaw, T., Grimm, O., Grube, J., Grudzińska, M., Grygorczuk, J., Guarino, V., Guglielmi, L., Guilloux, F., Gunji, S., Gyuk, G., Hadasch, D., Haefner, D., Hagiwara, R., Hahn, J., Hallgren, A., Hara, S., Hardcastle, M. J., Hassan, T., Haubold, T., Hauser, M., Hayashida, M., Heller, R., Henri, G., Hermann, G., Herrero, A., Hinton, J. A., Hoffmann, D., Hofmann, W., Hofverberg, P., Horns, D., Hrupec, D., Huan, H., Huber, B., Huet, J.-M., Hughes, G., Hultquist, K., Humensky, T. B., Huppert, J.-F., Ibarra, A., Illa, J. M., Ingjald, J., Inoue, Y., Inoue, S., Ioka, K., Jablonski, C., Jacholkowska, A., Janiak, M., Jean, P., Jensen, H., Jogler, T., Jung, I., Kaaret, P., Kabuki, S., Kakuwa, J., Kalkuhl, C., Kankanyan, R., Kapala, M., Karastergiou, A., Karczewski, M., Karkar, S., Karlsson, N., Kasperek, J., Katagiri, H., Katarzyński, K., Kawanaka, N., Kȩdziora, B., Kendziorra, E., Khélifi, B., Kieda, D., Kifune, T., Kihm, T., Klepser, S., Kluźniak, W., Knapp, J., Knappy, A. R., Kneiske, T., Knödlseder, J., Köck, F., Kodani, K., Kohri, K., Kokkotas, K., Komin, N., Konopelko, A., Kosack, K., Kossakowski, R., Kostka, P., Kotuła, J., Kowal, G., Kozioł, J., Krähenbühl, T., Krause, J., Krawczynski, H., Krennrich, F., Kretzschmann, A., Kubo, H., Kudryavtsev, V. 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A., Winde, M., Wischnewski, R., Wiśniewski, Ł., Wolczko, A., Wood, M., Xiong, Q., Yamamoto, T., Yamaoka, K., Yamazaki, R., Yanagita, S., Yoffo, B., Yonetani, M., Yoshida, A., Yoshida, T., Yoshikoshi, T., Zabalza, V., Zagdański, A., Zajczyk, A., Zdziarski, A., Zech, A., Ziȩtara, K., Ziółkowski, P., Zitelli, V., Zychowski, P., and The CTA Consortium

Published
2011
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5. Features of abnormal choroidal circulation in central serous chorioretinopathy. (Clinical Science)

Author

Kitaya, N., Nagaoka, T., Hikichi, T., Sugawara, R., Fukui, K., Ishiko, S., and Yoshida, A.

Subjects
Ophthalmology -- Research, Retinal diseases -- Research, Health
Abstract

Aims: To evaluate abnormalities in the choroidal circulation in cases of central serous chorioretinopathy (CSC). Methods: A complete clinical ophthalmological examination was performed using simultaneous fluorescein and indocyanine green (ICG) [...]

Published
2003

8. CTA contributions to the 33rd International Cosmic Ray Conference

Author

Abril, O., Acharya, B. S., Actis, M., Agnetta, G., Aguilar, J. A., Aharonian, F., Ajello, M., Akhperjanian, A., Alcubierre, M., Alfaro, J. Aleksic R., Aliu, E., Allafort, A. J., Allan, D., Allekotte, I., Aloisio, R., Amato, E., Ambrosi, G., Ambrosio, M., Anderson, J., Angüner, E. O., Antonelli, L. A., Antonuccio, V., Antonucci, M., Antoranz, P., Aravantinos, A., Argan, A., Arlen, T., Aramo, C., Armstrong, T., Arnaldi, H., Arrabito, L., Asano, K., Ashton, T., Asorey, H. G., Aune, T., Awane, Y., Baba, H., Babic, A., Baby, N., Bähr, J., Bais, A., Baixeras, C., Bajtlik, S., Balbo, M., Balis, D., Balkowski, C., Ballet, J., Bamba, A., Bandiera, R., Barber, A., Barbier, C., Barceló, M., Barnacka, A., Barnstedt, J., Barres de Almeida, U., Barrio, J. A., Basili, A., Basso, S., Bastieri, D., Bauer, C., Baushev, A., Becciani, U., Becerra, J., Becherini, Y., Bechtol, K. C., Becker Tjus, J., Beckmann, V., Bednarek, W., Behera, B., Belluso, M., Benbow, W., Berdugo, J., Berge, D., Berger, K., Bernard, F., Bernardino, T., Bernlöhr, K., Bertucci, B., Bhat, N., Bhattacharyya, S., Biasuzzi, B., Bigongiari, C., Biland, A., Billotta, S., Bird, T., Birsin, E., Bissaldi, E., Biteau, J., Bitossi, M., Blake, S., Blanch Bigas, O., Blasi, P., Bobkov, A., Boccone, V., Böttcher, M., Bogacz, L., Bogart, J., Bogdan, M., Boisson, C., Boix Gargallo, J., Bolmont, J., Bonanno, G., Bonardi, A., Bonev, T., Bonifacio, P., Bonnoli, G., Bordas, P., Borgland, A., Borkowski, J., Bose, R., Botner, O., Bottani, A., Bouchet, L., Bourgeat, M., Boutonnet, C., Bouvier, A., Brau Nogué, S., Braun, I., Bretz, T., Briggs, M., Brigida, M., Bringmann, T., Britto, R., Brook, P., Brun, P., Brunetti, L., Bruno, P., Bucciantini, N., Buanes, T., Buckley, J., Bühler, R., Bugaev, V., Bulgarelli, A., Bulik, T., Busetto, G., Buson, S., Byrum, K., Cailles, M., Cameron, R., Camprecios, J., Canestrari, R., Cantu, S., Capalbi, M., Caraveo, P., Carmona, E., Carosi, A., Carosi, R., Carr, J., Carter, J., Carton, P. H., Caruso, Rossella, Casanova, S., Cascone, E., Casiraghi, M., Castellina, A., Catalano, O., Cavazzani, S., Cazaux, S., Cerchiara, P., Cerruti, M., Chabanne, E., Chadwick, P., Champion, C., Chaves, R., Cheimets, P., Chen, A., Chiang, J., Chiappetti, L., Chikawa, M., Chitnis, V. R., Chollet, F., Christof, A., Chudoba, J., Cieślar, M., Cillis, A., Cilmo, M., Codino, A., Cohen Tanugi, J., Colafrancesco, S., Colin, P., Colome, J., Colonges, S., Compin, M., Conconi, P., Conforti, V., Connaughton, V., Conrad, J., Contreras, J. L., Coppi, P., Coridian, J., Corona, P., Corti, D., Cortina, J., Cossio, L., Costa, A., Costantini, H., Cotter, G., Courty, B., Couturier, S., Covino, S., Crimi, G., Criswell, S. J., Croston, J., Cusumano, G., Dafonseca, M., Dale, O., Daniel, M., Darling, J., Davids, I., Dazzi, F., de Angelis, A., De Caprio, V., De Frondat, F., de Gouveia Dal Pino, E. M., de la Calle, I., De La Vega, G. A., de los Reyes Lopez, R., de Lotto, B., De Luca, A., de Naurois, M., de Oliveira, Y., de Oña Wilhelmi, E., de Palma, F., de Souza, V., Decerprit, G., Decock, G., Deil, C., Delagnes, E., Deleglise, G., Delgado, C., della Volpe, D., Demange, P., Depaola, G., Dettlaff, A., Di Girolamo, T., Di Giulio, C., Di Paola, A., Di Pierro, F., di Sciascio, G., Díaz, C., Dick, J., Dickherber, R., Dickinson, H., Diez Blanco, V., Digel, S., Dimitrov, D., Disset, G., Djannati Ataï, A., Doert, M., Dohmke, M., Domainko, W., Dominis Prester, D., Donat, A., Dorner, D., Doro, M., Dournaux, J. L., Drake, G., Dravins, D., Drury, L., Dubois, F., Dubois, R., Dubus, G., Dufour, C., Dumas, D., Dumm, J., Durand, D., Dwarkadas, V., Dyks, J., Dyrda, M., Ebr, J., Edy, E., Egberts, K., Eger, P., Einecke, S., Eleftheriadis, C., Elles, S., Emmanoulopoulos, D., Engelhaupt, D., Enomoto, R., Ernenwein, J. P., Errando, M., Etchegoyen, A., Evans, P. A., Falcone, A., Faltenbacher, A., Fantinel, D., Farakos, K., Farnier, C., Farrell, E., Fasola, G., Favill, B. W., Fede, E., Federici, S., Fegan, S., Feinstein, F., Ferenc, D., Ferrando, P., Fesquet, M., Fetfatzis, P., Fiasson, A., Fillin Martino, E., Fink, D., Finley, C., Finley, J. P., Fiorini, M., Firpo Curcoll, R., Flandrini, E., Fleischhack, H., Flores, H., Florin, D., Focke, W., Föhr, C., Fokitis, E., Font, L., Fontaine, G., Fornasa, M., Förster, A., Fortson, L., Fouque, N., Franckowiak, A., Franco, F. J., Frankowski, A., Fransson, C., Fraser, G. W., Frei, R., Fresnillo, L., Fruck, C., Fugazza, D., Fujita, Y., Fukazawa, Y., Fukui, Y., Funk, S., Gäbele, W., Gabici, S., Gabriele, R., Gadola, A., Galante, N., Gall, D., Gallant, Y., Gámez García, J., Garczarczyk, M., García, B., Garcia López, R., Gardiol, D., Gargano, F., Garrido, D., Garrido, L., Gascon, D., Gaug, M., Gaweda, J., Gebremedhin, L., Geffroy, N., Gerard, L., Ghedina, A., Ghigo, M., Ghislain, P., Giannakaki, E., Gianotti, F., Giarrusso, S., Giavitto, G., Giebels, B., Giglietto, N., Gika, V., Giomi, M., Giommi, P., Giordano, F., Girard, N., Giro, E., Giuliani, A., Glanzman, T., Glicenstein, J. F., Godinovic, N., Golev, V., Gomez Berisso, M., Gómez Ortega, J., Gonzalez, M. M., González, A., González, F., González Muñoz, A., Gothe, K. S., Grabarczyk, T., Gougerot, M., Graciani, R., Grandi, P., Grañena, F., Granot, J., Grasseau, G., Gredig, R., Green, A., Greenshaw, T., Grégoire, T., Grillo, A., Grimm, O., Grondin, M. 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A., Kushida, J., Kuznetsov, A., La Barbera, A., La Palombara, N., La Parola, V., La Rosa, G., Lacombe, K., Lamanna, G., Lande, J., Languignon, D., Lapington, J. S., Laporte, P., Laurent, B., Lavalley, C., Le Flour, T., Le Padellec, A., Lee, S. H., Lee, W. H., Lefèvre, J. P., Leich, H., Leigui de Oliveira, M. A., Lelas, D., Lenain, J. P., Leoni, R., Leopold, D. J., Lerch, T., Lessio, L., Leto, G., Lieunard, B., Lieunard, S., Lindemann, R., Lindfors, E., Liolios, A., Lipniacka, A., Lockart, H., Lohse, T., Lombardi, S., Longo, F., Lopatin, A., Lopez, M., López Coto, R., López Oramas, A., Lorca, A., Lorenz, E., Louis, F., Lubinski, P., Lucarelli, F., Lüdecke, H., Ludwin, J., Luque Escamilla, P. L., Lustermann, W., Luz, O., Lyard, E., Maccarone, M. C., Maccarone, T. J., Madejski, G. M., Madhavan, A., Mahabir, M., Maier, G., Majumdar, P., Malaguti, G., Malaspina, G., Maltezos, S., Manalaysay, A., Mancilla, A., Mandat, D., Maneva, G., Mangano, A., Manigot, P., Mannheim, K., Manthos, I., Maragos, N., Marcowith, A., Mariotti, M., Marisaldi, M., Markoff, S., Marszałek, A., Martens, C., Martí, J., Martin, J. M., Martin, P., Martínez, G., Martínez, F., Martínez, M., Massaro, F., Masserot, A., Mastichiadis, A., Mathieu, A., Matsumoto, H., Mattana, F., Mattiazzo, S., Maurer, A., Maurin, G., Maxfield, S., Maya, J., Mazin, D., Mc Comb, L., Mccann, A., Mccubbin, N., Mchardy, I., Mckay, R., Meagher, K., Medina, C., Melioli, C., Melkumyan, D., Melo, D., Mereghetti, S., Mertsch, P., Meucci, M., Meyer, M., Michałowski, J., Micolon, P., Mihailidis, A., Mineo, T., Minuti, M., Mirabal, N., Mirabel, F., Miranda, J. M., Mirzoyan, R., Mistò, A., Mizuno, T., Moal, B., Moderski, R., Mognet, I., Molinari, E., Molinaro, M., Montaruli, T., Monte, C., Monteiro, I., Moore, P., Moralejo Olaizola, A., Mordalska, M., Morello, C., Mori, K., Morlino, G., Morselli, A., Mottez, F., Moudden, Y., Moulin, E., Mrusek, I., Mukherjee, R., Munar Adrover, P., Muraishi, H., Murase, K., Murphy, A. S. t. J., Nagataki, S., Naito, T., Nakajima, D., Nakamori, T., Nakayama, K., Naumann, C., Naumann, D., Naumann Godo, M., Nayman, P., Nedbal, D., Neise, D., Nellen, L., Neronov, A., Neustroev, V., Neyroud, N., Nicastro, L., Nicolau Kukliński, J., Niedźwiecki, A., Niemiec, J., Nieto, D., Nikolaidis, A., Nishijima, K., Nishikawa, K. I., Noda, K., Nolan, S., Northrop, R., Nosek, D., Nowak, N., Nozato, A., Oakes, L., O'Brien, P. T., Ohira, Y., Ohishi, M., Ohm, S., Ohoka, H., Okuda, T., Okumura, A., Olive, J. F., Ong, R. A., Orito, R., Orr, M., Osborne, J. P., Ostrowski, M., Otero, L. A., Otte, N., Ovcharov, E., Oya, I., Ozieblo, A., Padilla, L., Pagano, I., Paiano, S., Paillot, D., Paizis, A., Palanque, S., Palatka, M., Pallota, J., Palatiello, M., Panagiotidis, K., Panazol, J. L., Paneque, D., Panter, M., Panzera, M. R., Paoletti, R., Papayannis, A., Papyan, G., Paredes, J. M., Pareschi, G., Parraud, J. M., Parsons, D., Pauletta, G., Paz Arribas, M., Pech, M., Pedaletti, G., Pelassa, V., Pelat, D., Perez, M. d. C., Persic, M., Petrucci, P. O., Peyaud, B., Pichel, A., Pieloth, D., Pierre, E., Pita, S., Pivato, G., Pizzolato, F., Platino, M., Platos, Ł., Platzer, R., Podkladkin, S., Pogosyan, L., Pohl, M., Pojmanski, G., Ponz, J. D., Potter, W., Poutanen, J., Prandini, E., Prast, J., Preece, R., Profeti, F., Prokoph, H., Prouza, M., Proyetti, M., Puerto Giménez, I., Pühlhofer, G., Puljak, I., Punch, M., Pyzioł, R., Quel, E. J., Quesada, J., Quinn, J., Quirrenbach, A., Racero, E., Rainò, S., Rajda, P. J., Rameez, M., Ramon, P., Rando, R., Rannot, R. C., Rataj, M., Raue, M., Ravignani, D., Reardon, P., Reimann, O., Reimer, A., Reimer, O., Reitberger, K., Renaud, M., Renner, S., Reville, B., Rhode, W., Ribó, M., Ribordy, M., Richards, G., Richer, M. G., Rico, J., Ridky, J., Rieger, F., Ringegni, P., Ripken, J., Ristori, P. R., Rivière, A., Rivoire, S., Rob, L., Rodeghiero, G., Roeser, U., Rohlfs, R., Rojas, G., Romano, P., Romaszkan, W., Romero, G. E., Rosen, S. R., Rosier Lees, S., Ross, D., Rouaix, G., Rousselle, J., Rousselle, S., Rovero, A. C., Roy, F., Royer, S., Rudak, B., Rulten, C., Rupiński, M., Russo, F., Ryde, F., Saavedra, O., Sacco, B., Saemann, E. O., Saggion, A., Sahakian, V., Saito, K., Saito, T., Saito, Y., Sakaki, N., Sakonaka, R., Salini, A., Sanchez, F., Sanchez Conde, M., Sandoval, A., Sandaker, H., Sant'Ambrogio, E., Santangelo, A., Santos, E. M., Sanuy, A., Sapozhnikov, L., Sarkar, S., Sartore, N., Sasaki, H., Satalecka, K., Sawada, M., Scalzotto, V., Scapin, V., Scarcioffolo, M., Schafer, J., Schanz, T., Schlenstedt, S., Schlickeiser, R., Schmidt, T., Schmoll, J., Schovanek, P., Schroedter, M., Schubert, A., Schultz, C., Schultze, J., Schulz, A., Schure, K., Schussler, F., Schwab, T., Schwanke, U., Schwarz, J., Schwarzburg, S., Schweizer, T., Schwemmer, S., Schwendicke, U., Schwerdt, C., Segreto, A., Seiradakis, J. H., Sembroski, G. H., Servillat, M., Seweryn, K., Sharma, M., Shayduk, M., Shellard, R. C., Shi, J., Shibata, T., Shibuya, A., Shore, S., Shum, E., Sideras Haddad, E., Sidoli, L., Sidz, M., Sieiro, J., Sikora, M., Silk, J., Sillanpää, A., Singh, B. B., Sironi, G., Sitarek, J., Skole, C., Smareglia, R., Smith, A., Smith, D., Smith, J., Smith, N., Sobczyńska, D., Sol, H., Sottile, G., Sowiński, M., Spanier, F., Spiga, D., Spyrou, S., Stamatescu, V., Stamerra, A., Starling, R. L. C., Stawarz, Ł., Steenkamp, R., Stegmann, C., Steiner, S., Stella, C., Stergioulas, N., Sternberger, R., Sterzel, M., Stinzing, F., Stodulski, M., Stolarczyk, T. h., Straumann, U., Strazzeri, E., Stringhetti, L., Suarez, A., Suchenek, M., Sugawara, R., Sulanke, K. H., Sun, S., Supanitsky, A. D., Suric, T., Sutcliffe, P., Sykes, J. M., Szanecki, M., Szepieniec, T., Szostek, A., Tagliaferri, G., Tajima, H., Takahashi, H., Takahashi, K., Takalo, L., Takami, H., Talbot, G., Tammi, J., Tanaka, M., Tanaka, S., Tasan, J., Tavani, M., Tavernet, J. P., Tejedor, L. A., Telezhinsky, I., Temnikov, P., Tenzer, C., Terada, Y., Terrier, R., Teshima, M., Testa, V., Tezier, D., Thayer, J., Thuermann, D., Tibaldo, L., Tibolla, O., Tiengo, A., Timpanaro, M. C., Tluczykont, M., Todero Peixoto, C. J., Tokanai, F., Tokarz, M., Toma, K., Tonachini, A., Torii, K., Tornikoski, M., Torres, D. F., Torres, M., Toscano, S., Toso, G., Tosti, G., Totani, T., Toussenel, F., Tovmassian, G., Travnicek, P., Treves, A., Trifoglio, M., Troyano, I., Tsinganos, K., Ueno, H., Umana, G., Umehara, K., Upadhya, S. S., Usher, T., Uslenghi, M., Vagnetti, F., Valdes Galicia, J. F., Vallania, P., Vallejo, G., van Driel, W., van Eldik, C., Vandenbrouke, J., Vanderwalt, J., Vankov, H., Vasileiadis, G., Vassiliev, V., Veberic, D., Vegas, I., Vercellone, S., Vergani, S., Verzi, V., Vettolani, G. P., Veyssière, C., Vialle, J. P., Viana, A., Videla, M., Vigorito, C., Vincent, P., Vincent, S., Vink, J., Vlahakis, N., Vlahos, L., Vogler, P., Voisin, V., Vollhardt, A., von Gunten, H. P., Vorobiov, S., Vuerli, C., Waegebaert, V., Wagner, R., Wagner, R. G., Wagner, S., Wakely, S. P., Walter, R., Walther, T., Warda, K., Warwick, R. S., Wawer, P., Wawrzaszek, R., Webb, N., Wegner, P., Weinstein, A., Weitzel, Q., Welsing, R., Werner, M., Wetteskind, H., White, R. J., Wierzcholska, A., Wiesand, S., Wilhelm, A., Wilkinson, M. I., Williams, D. A., Willingale, R., Winde, M., Winiarski, K., Wischnewski, R., Wiśniewski, Ł., Wojcik, P., Wood, M., Wörnlein, A., Xiong, Q., Yadav, K. K., Yamamoto, H., Yamamoto, T., Yamazaki, R., Yanagita, S., Yebras, J. M., Yelos, D., Yoshida, A., Yoshida, T., Yoshikoshi, T., Yu, P., Zabalza, V., Zacharias, M., Zajczyk, A., Zampieri, L., Zanin, R., Zdziarski, A., Zech, A., Zhao, A., Zhou, X., Zietara, K., Ziolkowski, J., Ziółkowski, P., Zitelli, V., Zurbach, C., and Zychowski, P.

Published
2013

9. Design concepts for the Cherenkov Telescope Array CTA: An advanced facility for ground-based high-energy gamma-ray astronomy

Author

Actis, M. Agnetta, G. Aharonian, F. Akhperjanian, A. Aleksić, J. Aliu, E. Allan, D. Allekotte, I. Antico, F. Antonelli, L.A. Antoranz, P. Aravantinos, A. Arlen, T. Arnaldi, H. Artmann, S. Asano, K. Asorey, H. Bähr, J. Bais, A. Baixeras, C. Bajtlik, S. Balis, D. Bamba, A. Barbier, C. Barceló, M. Barnacka, A. Barnstedt, J. de Almeida, U.B. Barrio, J.A. Basso, S. Bastieri, D. Bauer, C. Becerra, J. Becherini, Y. Bechtol, K. Becker, J. Beckmann, V. Bednarek, W. Behera, B. Beilicke, M. Belluso, M. Benallou, M. Benbow, W. Berdugo, J. Berger, K. Bernardino, T. Bernlöhr, K. Biland, A. Billotta, S. Bird, T. Birsin, E. Bissaldi, E. Blake, S. Blanch, O. Bobkov, A.A. Bogacz, L. Bogdan, M. Boisson, C. Boix, J. Bolmont, J. Bonanno, G. Bonardi, A. Bonev, T. Borkowski, J. Botner, O. Bottani, A. Bourgeat, M. Boutonnet, C. Bouvier, A. Brau-Nogué, S. Braun, I. Bretz, T. Briggs, M.S. Brun, P. Brunetti, L. Buckley, J.H. Bugaev, V. Bühler, R. Bulik, T. Busetto, G. Buson, S. Byrum, K. Cailles, M. Cameron, R. Canestrari, R. Cantu, S. Carmona, E. Carosi, A. Carr, J. Carton, P.H. Casiraghi, M. Castarede, H. Catalano, O. Cavazzani, S. Cazaux, S. Cerruti, B. Cerruti, M. Chadwick, P.M. Chiang, J. Chikawa, M. Cieślar, M. Ciesielska, M. Cillis, A. Clerc, C. Colin, P. Colomé, J. Compin, M. Conconi, P. Connaughton, V. Conrad, J. Contreras, J.L. Coppi, P. Corlier, M. Corona, P. Corpace, O. Corti, D. Cortina, J. Costantini, H. Cotter, G. Courty, B. Couturier, S. Covino, S. Croston, J. Cusumano, G. Daniel, M.K. Dazzi, F. Angelis, A.d. de Cea del Pozo, E. de Gouveia Dal Pino, E.M. de Jager, O. de la Calle Pérez, I. de la Vega, G. de Lotto, B. de Naurois, M. de Oña Wilhelmi, E. de Souza, V. Decerprit, B. Deil, C. Delagnes, E. Deleglise, G. Delgado, C. Dettlaff, T. Di Paolo, A. Di Pierro, F. Díaz, C. Dick, J. Dickinson, H. Digel, S.W. Dimitrov, D. Disset, G. Djannati-Ataï, A. Doert, M. Domainko, W. Dorner, D. Doro, M. Dournaux, J.-L. Dravins, D. Drury, L. Dubois, F. Dubois, R. Dubus, G. Dufour, C. Durand, D. Dyks, J. Dyrda, M. Edy, E. Egberts, K. Eleftheriadis, C. Elles, S. Emmanoulopoulos, D. Enomoto, R. Ernenwein, J.-P. Errando, M. Etchegoyen, A. Falcone, A.D. Farakos, K. Farnier, C. Federici, S. Feinstein, F. Ferenc, D. Fillin-Martino, E. Fink, D. Finley, C. Finley, J.P. Firpo, R. Florin, D. Föhr, C. Fokitis, E. Font, L. Fontaine, G. Fontana, A. Förster, A. Fortson, L. Fouque, N. Fransson, C. Fraser, G.W. Fresnillo, L. Fruck, C. Fujita, Y. Fukazawa, Y. Funk, S. Gäbele, W. Gabici, S. Gadola, A. Galante, N. Gallant, Y. García, B. López, R.J.G. Garrido, D. Garrido, L. Gascón, D. Gasq, C. Gaug, M. Gaweda, J. Geffroy, N. Ghag, C. Ghedina, A. Ghigo, M. Gianakaki, E. Giarrusso, S. Giavitto, G. Giebels, B. Giro, E. Giubilato, P. Glanzman, T. Glicenstein, J.-F. Gochna, M. Golev, V. Berisso, M.G. González, A. González, F. Grañena, F. Graciani, R. Granot, J. Gredig, R. Green, A. Greenshaw, T. Grimm, O. Grube, J. Grudzińska, M. Grygorczuk, J. Guarino, V. Guglielmi, L. Guilloux, F. Gunji, S. Gyuk, G. Hadasch, D. Haefner, D. Hagiwara, R. Hahn, J. Hallgren, A. Hara, S. Hardcastle, M.J. Hassan, T. Haubold, T. Hauser, M. Hayashida, M. Heller, R. Henri, G. Hermann, G. Herrero, A. Hinton, J.A. Hoffmann, D. Hofmann, W. Hofverberg, P. Horns, D. Hrupec, D. Huan, H. Huber, B. Huet, J.-M. Hughes, G. Hultquist, K. Humensky, T.B. Huppert, J.-F. Ibarra, A. Illa, J.M. Ingjald, J. Inoue, Y. Inoue, S. Ioka, K. Jablonski, C. Jacholkowska, A. Janiak, M. Jean, P. Jensen, H. Jogler, T. Jung, I. Kaaret, P. Kabuki, S. Kakuwa, J. Kalkuhl, C. Kankanyan, R. Kapala, M. Karastergiou, A. Karczewski, M. Karkar, S. Karlsson, N. Kasperek, J. Katagiri, H. Katarzyński, K. Kawanaka, N. Kȩdziora, B. Kendziorra, E. Khélifi, B. Kieda, D. Kifune, T. Kihm, T. Klepser, S. Kluźniak, W. Knapp, J. Knappy, A.R. Kneiske, T. Knödlseder, J. Köck, F. Kodani, K. Kohri, K. Kokkotas, K. Komin, N. Konopelko, A. Kosack, K. Kossakowski, R. Kostka, P. Kotuła, J. Kowal, G. Kozioł, J. Krähenbühl, T. Krause, J. Krawczynski, H. Krennrich, F. Kretzschmann, A. Kubo, H. Kudryavtsev, V.A. Kushida, J. La Barbera, N. La Parola, V. La Rosa, G. López, A. Lamanna, G. Laporte, P. Lavalley, C. Le Flour, T. Le Padellec, A. Lenain, J.-P. Lessio, L. Lieunard, B. Lindfors, E. Liolios, A. Lohse, T. Lombardi, S. Lopatin, A. Lorenz, E. Lubiński, P. Luz, O. Lyard, E. Maccarone, M.C. Maccarone, T. Maier, G. Majumdar, P. Maltezos, S. Małkiewicz, P. Mañá, C. Manalaysay, A. Maneva, G. Mangano, A. Manigot, P. Marín, J. Mariotti, M. Markoff, S. Martínez, G. Martínez, M. Mastichiadis, A. Matsumoto, H. Mattiazzo, S. Mazin, D. McComb, T.J.L. McCubbin, N. McHardy, I. Medina, C. Melkumyan, D. Mendes, A. Mertsch, P. Meucci, M. Michałowski, J. Micolon, P. Mineo, T. Mirabal, N. Mirabel, F. Miranda, J.M. Mirzoyan, R. Mizuno, T. Moal, B. Moderski, R. Molinari, E. Monteiro, I. Moralejo, A. Morello, C. Mori, K. Motta, G. Mottez, F. Moulin, E. Mukherjee, R. Munar, P. Muraishi, H. Murase, K. Murphy, A.S. Nagataki, S. Naito, T. Nakamori, T. Nakayama, K. Naumann, C. Naumann, D. Nayman, P. Nedbal, D. Niedźwiecki, A. Niemiec, J. Nikolaidis, A. Nishijima, K. Nolan, S.J. Nowak, N. O'Brien, P.T. Ochoa, I. Ohira, Y. Ohishi, M. Ohka, H. Okumura, A. Olivetto, C. Ong, R.A. Orito, R. Orr, M. Osborne, J.P. Ostrowski, M. Otero, L. Otte, A.N. Ovcharov, E. Oya, I. Oziȩbło, A. Paiano, S. Pallota, J. Panazol, J.L. Paneque, D. Panter, M. Paoletti, R. Papyan, G. Paredes, J.M. Pareschi, G. Parsons, R.D. Arribas, M.P. Pedaletti, G. Pepato, A. Persic, M. Petrucci, P.O. Peyaud, B. Piechocki, W. Pita, S. Pivato, G. Płatos, Ł. Platzer, R. Pogosyan, L. Pohl, M. Pojmański, G. Ponz, J.D. Potter, W. Prandini, E. Preece, R. Prokoph, H. Pühlhofer, G. Punch, M. Quel, E. Quirrenbach, A. Rajda, P. Rando, R. Rataj, M. Raue, M. Reimann, C. Reimann, O. Reimer, A. Reimer, O. Renaud, M. Renner, S. Reymond, J.-M. Rhode, W. Ribó, M. Ribordy, M. Rico, J. Rieger, F. Ringegni, P. Ripken, J. Ristori, P. Rivoire, S. Rob, L. Rodriguez, S. Roeser, U. Romano, P. Romero, G.E. Rosier-Lees, S. Rovero, A.C. Roy, F. Royer, S. Rudak, B. Rulten, C.B. Ruppel, J. Russo, F. Ryde, F. Sacco, B. Saggion, A. Sahakian, V. Saito, K. Saito, T. Sakaki, N. Salazar, E. Salini, A. Sánchez, F. Conde, M.Á.S. Santangelo, A. Santos, E.M. Sanuy, A. Sapozhnikov, L. Sarkar, S. Scalzotto, V. Scapin, V. Scarcioffolo, M. Schanz, T. Schlenstedt, S. Schlickeiser, R. Schmidt, T. Schmoll, J. Schroedter, M. Schultz, C. Schultze, J. Schulz, A. Schwanke, U. Schwarzburg, S. Schweizer, T. Seiradakis, J. Selmane, S. Seweryn, K. Shayduk, M. Shellard, R.C. Shibata, T. Sikora, M. Silk, J. Sillanpää, A. Sitarek, J. Skole, C. Smith, N. Sobczyńska, D. Haro, M.S. Sol, H. Spanier, F. Spiga, D. Spyrou, S. Stamatescu, V. Stamerra, A. Starling, R.L.C. Stawarz, Ł. Steenkamp, R. Stegmann, C. Steiner, S. Stergioulas, N. Sternberger, R. Stinzing, F. Stodulski, M. Straumann, U. Suárez, A. Suchenek, M. Sugawara, R. Sulanke, K.H. Sun, S. Supanitsky, A.D. Sutcliffe, P. Szanecki, M. Szepieniec, T. Szostek, A. Szymkowiak, A. Tagliaferri, G. Tajima, H. Takahashi, H. Takahashi, K. Takalo, L. Takami, H. Talbot, R.G. Tam, P.H. Tanaka, M. Tanimori, T. Tavani, M. Tavernet, J.-P. Tchernin, C. Tejedor, L.A. Telezhinsky, I. Temnikov, P. Tenzer, C. Terada, Y. Terrier, R. Teshima, M. Testa, V. Tibaldo, L. Tibolla, O. Tluczykont, M. Peixoto, C.J.T. Tokanai, F. Tokarz, M. Toma, K. Torres, D.F. Tosti, G. Totani, T. Toussenel, F. Vallania, P. Vallejo, G. van der Walt, J. van Eldik, C. Vandenbroucke, J. Vankov, H. Vasileiadis, G. Vassiliev, V.V. Vegas, I. Venter, L. Vercellone, S. Veyssiere, C. Vialle, J.P. Videla, M. Vincent, P. Vink, J. Vlahakis, N. Vlahos, L. Vogler, P. Vollhardt, A. Volpe, F. von Gunten, H.P. Vorobiov, S. Wagner, S. Wagner, R.M. Wagner, B. Wakely, S.P. Walter, P. Walter, R. Warwick, R. Wawer, P. Wawrzaszek, R. Webb, N. Wegner, P. Weinstein, A. Weitzel, Q. Welsing, R. Wetteskind, H. White, R. Wierzcholska, A. Wilkinson, M.I. Williams, D.A. Winde, M. Wischnewski, R. Wiśniewski, Ł. Wolczko, A. Wood, M. Xiong, Q. Yamamoto, T. Yamaoka, K. Yamazaki, R. Yanagita, S. Yoffo, B. Yonetani, M. Yoshida, A. Yoshida, T. Yoshikoshi, T. Zabalza, V. Zagdański, A. Zajczyk, A. Zdziarski, A. Zech, A. Ziȩtara, K. Ziółkowski, P. Zitelli, V. Zychowski, P.

Subjects
Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Instrumentation and Methods for Astrophysics
Abstract

Ground-based gamma-ray astronomy has had a major breakthrough with the impressive results obtained using systems of imaging atmospheric Cherenkov telescopes. Ground-based gamma-ray astronomy has a huge potential in astrophysics, particle physics and cosmology. CTA is an international initiative to build the next generation instrument, with a factor of 5-10 improvement in sensitivity in the 100 GeV-10 TeV range and the extension to energies well below 100 GeV and above 100 TeV. CTA will consist of two arrays (one in the north, one in the south) for full sky coverage and will be operated as open observatory. The design of CTA is based on currently available technology. This document reports on the status and presents the major design concepts of CTA. © 2011 The Author(s).

Published
2011

11. Sub optimum quantum measurement for M-ary ASK applicable to Y-00 cryptosystem.

Author

Nagasako, Y., Suemitu, H., Sugawara, R., Sohma, M., and Hirota, O.

Subjects
QUANTUM theory, CRYPTOGRAPHY, INDUSTRIAL productivity, PHASE shift (Nuclear physics), SCATTERING (Physics)
Abstract

Recently quantum stream cipher based on quantum detection theory so called Yuen-2000 protocol has been developed in both theory and experiment. There are two types of implementation of Y-00 scheme. One is by phase shift keying (PSK), and another is by amplitude or intensity shift keying (ASK). One of the evaluation methods for such stream cipher is a success probability by quantum optimum receiver. In the case of PSK, the signal states have a property of symmetric group, and the quantum limitation has been calculated by our group. In that case, the optimum detection becomes so called square root measurement. Since we are developing Y-00 quantum stream cipher by ASK, we want to clarify the limitation of the attacker in the case of ASK. But in this case, it has no property as group theory, so it is at present difficult to obtain the optimum solution. In this letter, we show the performance of a square root measurement for ASK as sub-optimum receiver and discuss an evaluation of the Y-00 protocol by ASK system. [ABSTRACT FROM AUTHOR]

Published
2009
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12. Musical combinatorics, tonnetz, and the CubeHarmonic

Author

Mannone Maria, Kitamura Eri, Huang Jiawei, Sugawara Ryo, and Kitamura Yoshifumi

Subjects
group theory, rubik's cube, motion tracking, Arts in general, NX1-820
Abstract

In this paper, we give an overview of some applications of combinatorics and permutations in music through the centuries. The concepts of permutation and tonnetz (spatial representation of voice leading and modulation) can be joined together in a physical device, the CubeHarmonic, a musical version of the Rubik's cube. We finally describe a prototype of the CubeHarmonic that uses the magnetic tracking technology developed at the Tohoku University.

Published
2018

14. Peroxynitrite decomposition catalyst, FP15, and poly(ADP-ribose) polymerase inhibitor, PJ34, inhibit leukocyte entrapment in the retinal microcirculation of diabetic rats.

Author

Sugawara, R., Hikichi, T., Kitaya, N., Mori, F., Nagaoka, T., Yoshida, A., and Szabo, C.

Subjects
*DIABETES, *INTRAPERITONEAL injections, *CATALYSTS, *LEUCOCYTES, *LABORATORY rats, *MICROCIRCULATION
Abstract

Purpose. Oxidative and nitrosative stress and activation of poly(ADP ribose) polymerase (PARP) play a role in the pathogenesis of diabetic complications. We evaluated the effectiveness of the peroxynitrite decomposition catalyst, PP 15, and the PARP inhibitor, PJ34, in the treatment of leukocyte entrapment in the retinal microcirculation of diabetic rats. Methods. Diabetes was induced in rats by intraperitoneal injection of 60mg/kg of streptozotocin. Rats were divided into four groups: controls; untreated diabetes; diabetes treated with PP 15 (10 mg/kg oral gavage twice daily) and diabetes treated with PJ34 (10mg/kg oral gavage twice daily). All experiments were performed 4 weeks after initiation of treatment. Leukocyte entrapment in the retinal microcirculation was quantitatively evaluated in vivo with acridine orange digital fluorography. Results, The density of leukocytes trapped in the retinal microcirculation 30 minutes after dye injection was significantly greater in untreated diabetes (32.1 ± 4.7 cells/mm²) than in controls (11.3 ± 4.5 cells/mm²) (p <0.05). Compared with untreated diabetes, the density of trapped leukocytes significantly decreased in diabetes treated with FP15 (14.5 ± 5.1 cells/mm²) (p <0.0001) and diabetes treated with PJ34 (24.1 ± 4.2 cells/mm²) (p <0.05). Conclusions. Treatment with FP15 and PJ34 decreased enhanced leukocyte entrapment in the retinal microcirculation during the early diabetic period. The current study suggests a role for peroxynitrite production and for PARP activation in the pathogenesis of retinal microvascular leukostasis in early diabetes. [ABSTRACT FROM AUTHOR]

Published
2004
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23. Radiation exposure in pediatric patients with early onset scoliosis: A longitudinal single-center study.

Author

Sugawara R, Watanabe H, Taki N, Onuma S, Kikkawa I, and Takeshita K

Subjects
Humans, Female, Male, Retrospective Studies, Child, Preschool, Child, Longitudinal Studies, Radiation Dosage, Tomography, X-Ray Computed, Infant, Age of Onset, Adolescent, Scoliosis surgery, Scoliosis diagnostic imaging, Radiation Exposure adverse effects
Abstract

Background: There is no consensus regarding the acceptable level of medical radiation exposure in patients with early-onset scoliosis. This study aimed to quantify radiation exposure in these patients and investigate factors associated with high exposure., Methods: Patients with early-onset scoliosis who received care for their spine deformity and other comorbidities in our institution were retrospectively reviewed. Cumulative radiation exposure and total number of imaging studies were recorded. Patients with ≥30 mSv exposure were classified as high exposure and analyzed to clarify factors associated with high exposure., Results: Thirty-five patients were included for analysis. The etiology of scoliosis was idiopathic in 8 patients, congenital in 7, syndromic in 8, and neuromuscular in 12. Fifteen patients underwent 19 spinal surgeries. The types of operation performed were definitive fusion (n = 12), vertebrectomy for hemivertebra (n = 2), growing rod (n = 1), lengthening (n = 3), and revision/partial implant removal (n = 1). The mean cumulative radiation dose was 22.3 mSv (range, 2.5-94.5 mSv). Spine radiography and computed tomography combined accounted for 15.0 mSv (range, 2.4-52.5 mSv, 67.3% of the mean cumulative dose). The mean radiation dose was significantly higher in patients who underwent spinal surgery than in those who did not (31.2 mSv vs. 15.6 mSv). The high-exposure group comprised 10 patients (1 idiopathic, 1 congenital, 5 syndromic, and 3 neuromuscular scoliosis) and 8 underwent 11 spinal operations. Among 8 patients who underwent spinal surgery, the cumulative radiation dose for spine was ≥30 mSv and spine computed tomography was performed an average of 4.0 times., Conclusions: Nearly one-third of patients with early-onset scoliosis and half of patients who underwent spinal surgery had >30 mSv radiation exposure due to multiple computed tomography. Medical radiation exposure and associated cancer risk should be considered when treating these patients., Competing Interests: Declaration of competing interest All authors have no conflicts of interest to declare relevant to this article., (Copyright © 2023 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.)

Published
2024
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24. Evaluation of crankshaft phenomenon after posterior fusion for early onset scoliosis using an inverse trigonometric function: a multicenter retrospective cohort study.

Author

Okuwaki S, Kotani T, Taniguchi Y, Suzuki T, Yamaguchi T, Demura S, Wada K, Sugawara R, Takeshita K, Watanabe K, Akazawa T, and Kawakami N

Abstract

Purpose: The crankshaft phenomenon (CSP) is a corrective loss after posterior surgery for early onset scoliosis (EOS). However, an accurate method for CSP evaluation has yet to be developed. In this study, we evaluated pedicle screw (PS) length and rotation angle using an inverse trigonometric function and investigated the prevalence of the CSP., Methods: Fifty patients from nine institutions (mean age 10.6 years, male/female ratio 4:46) who underwent early definitive fusion surgery at ≤ 11 years of age were included. The rotation angle was calculated as arctan (lateral/frontal PS length) using radiography. Measurements were taken at the apex and lower instrumented vertebra (LIV) immediate, 2-, and 5-year postoperatively. CSP was defined as a rotation angle progression ≥ 5°. We divided patients into CSP and non-CSP groups and measured the demographic parameters, Risser grade, state of the triradiate cartilage, major coronal Cobb angle, T1-T12 length, T1-S1 length, and presence of distal adding-on (DAO). We compared these variables between groups and investigated the correlation between the measured variables and vertebral rotation. Logistic regression analysis investigated factors associated with CSP., Results: The rotation angle progressed by 2.4 and 1.3° over 5 years for the apex and LIV, respectively. CSP occurred in 15 cases (30%), DAO in 11 cases (22%), and CSP and DAO overlapped in 4 cases (8%). In the CSP group, the T1-T12 length was low immediate postoperatively. The rotation angle was negatively correlated with preoperative height (r = - 0.33), T1-T12 length (r = - 0.35), and T1-S1 length (r = - 0.30). A lower preoperative T1-T12 length was associated with CSP (odds ratio: 0.996, p = 0.048)., Conclusions: CSP occurred in 30% of patients with EOS who underwent definitive fusion. The presence of CSP was associated with a lower preoperative T1-T12 length., Level of Evidence: Diagnosis, level IV., (© 2024. The Author(s), under exclusive licence to Scoliosis Research Society.)

Published
2024
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25. Evolution of Pleural Solitary Fibrous Tumors Causing Severe Hypoglycemia after Exceptionally Long Asymptomatic Periods: Report of Two Surgical Cases.

Author

Suzuki T, Notsuda H, Oishi H, Niikawa H, Watanabe T, Watanabe Y, Onodera K, Takeda T, Sugawara R, Noda M, Sakurai K, Nagao M, Fukuda I, and Okada Y

Subjects
Humans, Insulin-Like Growth Factor II metabolism, Tomography, X-Ray Computed, Hypoglycemia etiology, Solitary Fibrous Tumor, Pleural surgery, Solitary Fibrous Tumor, Pleural complications, Solitary Fibrous Tumor, Pleural pathology, Solitary Fibrous Tumor, Pleural diagnostic imaging
Abstract

Non-islet cell tumor hypoglycemia (NICTH) is one of the paraneoplastic syndromes manifesting severe hypoglycemia caused by aberrant production of high-molecular-weight insulin-like growth factor 2 (big-IGF2). Two surgical cases of extremely large thoracic solitary fibrous tumors (SFT) with unusual history of NICTH are presented. One case manifested severe hypoglycemia after four years of the first complete surgical resection of the tumor with potential malignant transformation, and the other case showed severe hypoglycemia after ten years of the first detection of the tumor. Meticulous laboratory testing, including serum endocrinological tests and western immunoblotting before and after surgery was performed, and both cases were diagnosed as NICTH. Both patients underwent open thoracic surgery. The patients showed normal glucose and hormone levels immediately after the resection of responsible tumors with elevated blood insulin concentration. SFTs are generally considered benign; however, life-threatening hypoglycemia can happen regardless of treatment. Careful follow-up of the tumor growth is warranted.

Published
2024
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26. Two new Mycena section Calodontes species: One newly discovered and the other new to Japan.

Author

Nagamune K, Hosaka K, Kigawa S, Sugawara R, Sotome K, Nakagiri A, and Endo N

Abstract

In 2017, two candidate species of Mycena were reported from Japan, with the Japanese names " Togari-sakura-take " and " Mitsuhida-sakura-take ". However, to date, no taxonomic study or formal description has been undertaken for these two species. In the present study, we conducted comprehensive morphological and molecular phylogenetic examinations of " Togari-sakura-take " and " Mitsuhida-sakura-take ", and compared them to known species within the genus Mycena . We performed phylogenetic analyses on a concatenated dataset, including the internal transcribed spacer region of ribosomal RNA, RNA polymerase II largest subunit, and translation elongation factor-1 alpha genes. " Togari-sakura-take " formed a clade with Mycena subulata , which was recently described from China, whereas " Mitsuhida-sakura-take " formed a distinct independent clade. We identified the former as M . subulata based on molecular phylogenetic analyses and morphological observations. However, the Japanese specimens displayed dextrinoid cheilocystidia and caulocystidia as well as the inamyloidity of basidiospores, which differed from the original description of M . subulata based on the materials from China. " Mitsuhida-sakura-take " was characterized by its remarkably dense lamellae and could be distinguished from known Mycena species by the combination of absent pleurocystidia and presence of bowling pin-shaped cheilocystidia. Here, we describe " Mitsuhida-sakura-take " as a new species, named Mycena densilamellata , in the section Calodontes ., (2024, by The Mycological Society of Japan.)

Published
2024
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27. Ossification of the anterior longitudinal ligament affects the severity and distribution of neurological deficits following spinal cord injury without radiological abnormality.

Author

Kimura A, Shiraishi Y, Sawamura H, Sugawara R, Inoue H, and Takeshita K

Subjects
Humans, Male, Female, Retrospective Studies, Aged, Middle Aged, Magnetic Resonance Imaging, Ossification, Heterotopic diagnostic imaging, Ossification, Heterotopic etiology, Tomography, X-Ray Computed, Longitudinal Ligaments diagnostic imaging, Cervical Vertebrae diagnostic imaging, Aged, 80 and over, Severity of Illness Index, Ossification of Posterior Longitudinal Ligament diagnostic imaging, Ossification of Posterior Longitudinal Ligament complications, Adult, Spinal Cord Injuries complications, Spinal Cord Injuries physiopathology, Spinal Cord Injuries diagnostic imaging
Abstract

Background: The incidence of spinal cord injury without radiological abnormality (SCIWORA) is increasing among older adults in developed countries. SCIWORA is commonly associated with ossification of the spinal ligament, specifically the ossification of the posterior longitudinal ligament (OPLL) and ossification of the anterior longitudinal ligament (OALL). OALL induces segmental spinal fusion and alters the biomechanical properties of the cervical spine; however, whether OALL modulates the severity of SCIWORA remains unknown. This study aimed to investigate the influence of OALL on the severity and distribution of neurological deficits following SCIWORA., Methods: This retrospective study included 122 patients with SCIWORA who were admitted to our hospital from April 2008 to March 2022. The neurological function of all the included patients was assessed via the American Spinal Injury Association (ASIA) Impairment Scale (AIS) at admission. Magnetic resonance imaging (MRI) and computed tomography were performed within 48 h of trauma. Central cord syndrome (CCS) was defined as the upper-extremity ASIA motor score being at least 10 points lesser than the lower-extremity motor score., Results: The study included 122 patients with a mean age of 65.1 years. Comparing mild (AIS grades C or D) and severe (AIS grades A or B) neurological deficits revealed that the former was independently associated with ground-level falls, OALL, and absence of prevertebral T2 high-intensity area on MRI. Although 39% of patients with SCIWORA exhibited OPLL as an etiology of cervical stenosis, OPLL demonstrated no significant effect on the severity of neurological deficits. CCS occurrence was independently associated with OALL and a larger cross-sectional cord area on MRI. Patients with OALL had significantly higher lower-extremity ASIA motor scores than those without OALL., Conclusions: OALL was significantly associated with mild neurological deficits in the lower extremities and with the occurrence of CCS after SCIWORA., Competing Interests: Declaration of competing interest None., (Copyright © 2023 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.)

Published
2024
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28. Immunophenotypic profiles in chalazion and pyogenic granuloma associated with chalazion.

Author

Nemoto R, Usui Y, Komatsu H, Tsubota K, Sugawara R, Nagao T, and Goto H

Subjects
Male, Adult, Humans, Female, Young Adult, Middle Aged, Immunophenotyping, CD4-Positive T-Lymphocytes metabolism, CD4-Positive T-Lymphocytes pathology, CD8-Positive T-Lymphocytes metabolism, CD8-Positive T-Lymphocytes pathology, Flow Cytometry, Chalazion metabolism, Granuloma, Pyogenic diagnosis, Granuloma, Pyogenic metabolism, Granuloma, Pyogenic pathology
Abstract

Purpose: To evaluate immunophenotypic profiles of infiltrating cells in surgically excised tissues of chalazion and pyogenic granuloma associated with chalazion., Methods: Eighty-two surgical specimens from 74 consecutive patients newly diagnosed with chalazion or chalazion-associated pyogenic granuloma at Tokyo Medical University Hospital between 2016 and 2022 were studied. Sixty specimens were chalazion lesions and 22 specimens were pyogenic granuloma lesions (from 15 men and 7 women, mean age 36.6 ± 14.4 years). All patients were immunocompetent Asian Japanese adults. Specimens were analyzed by immunohistochemistry and flow cytometry. Flow cytometry was performed using the following antibodies: CD3, CD4, CD8, CD11b, CD11c, CD16, CD19, CD20, CD23, CD25, CD34, CD44, CD56, CD69, and CD138., Results: In flow cytometric analysis, the proportion of cells expressing the T cell marker CD3 was significantly higher compared with other immune cells expressing specific markers (p < 0.0001), and the proportion of CD4-positive T cells was significantly higher than that of CD8-positive T cells (p < 0.0001), in both chalazion and pyogenic granuloma specimens. The chalazion and pyogenic granuloma lesions shared similar immunophenotypic profile characterized by predominant T cell infiltration, and CD4 T cells dominating over CD8 cells. The pattern of expression of CD4 and CD8 in the specimens was confirmed by immunohistochemistry., Conclusion: The present study demonstrates immunophenotypic features of chalazion and chalazion-associated pyogenic granuloma. Although various inflammatory cells are involved in the pathology of chalazion and pyogenic granuloma, a significantly higher proportion of CD4-positive T cells may be closely related to the pathological mechanisms of both lesions., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Published
2024
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29. Amanita satotamagotake sp. nov., a cryptic species formerly included in Amanita caesareoides .

Author

Kodaira M, Aoki W, Endo N, Sakuma D, Hadano E, Hadano A, Hashimoto Y, Gisusi S, Yamamoto K, Sugawara R, Fukuda M, and Yamada A

Abstract

We evaluated the inclusion of a cryptic species in a Japanese Amanita caesareoides population. We sampled A. caesareoides specimens under various vegetation and climate conditions, and then conducted phylogenetic analyses on sequences from seven loci. The A. caesareoides specimens showed two distinct groups, except when the ITS phylogeny was considered. These two phylogroups showed different distributions: subalpine-cool temperate and temperate-subtropical areas. Although these two phylogroups overlapped in terms of basidiospore size, the latter tended to exhibit smaller basidiospores. In addition, only the former showed mycelial growth on nutrient agar. Based on these phylo-morpho-ecophysiological characteristics, we separated the specimens labeled with the name A. caesareoides into two species. As the lectotype of A. caesareoides showed similarity to the former by DNA analysis, the latter was described as a new species, namely A. satotamagotake . Based on the geographic patterns of the two species, A. satotamagotake may have invaded the natural habit of A. caesareoides because of global warming., Competing Interests: The authors of this study have no conflicts of interest to declare., (2024, by The Mycological Society of Japan.)

Published
2024
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30. The Validation of the Japanese Version of the Scoliosis Research Society-30 Questionnaire for Adolescent Idiopathic Scoliosis Patients.

Author

Arima H, Yamato Y, Shibata Y, Oba H, Takahashi J, Watanabe K, Sugawara R, Takeshita K, Omura T, Carreon L, Arai Y, Asada T, Demura S, Doi T, Matsumura A, Suzuki S, Takahashi S, Takeuchi T, Ueda H, and Hosogane N

Abstract

Introduction: The Scoliosis Research Society-30 (SRS-30) is a questionnaire originally developed from the SRS-22r questionnaire and is used to evaluate adolescent idiopathic scoliosis (AIS). It comprised questions on five domains: function, pain, self-image, mental health, and satisfaction, with seven additional questions related to postoperative aspects. In addition to the original English version, translations in multiple languages have been effectively applied. Herein, we evaluated the internal consistency and external validity of the Japanese version of the SRS-30 for AIS patients., Methods: Among the 30 questions in SRS-30, the eight additional questions from SRS-22r were translated and back-translated to create a Japanese version of the SRS-30. This translated questionnaire was then used to survey patients with AIS who underwent corrective fusion surgery one year postoperatively. The internal consistency of the responses was evaluated using the Cronbach α coefficient. Additionally, the Spearman correlation analyses were conducted to assess the correlation between the scores obtained from the SRS-30 Japanese version and SRS-22r and the Oswestry Disability Index (ODI) for the overall scale and the five domains., Results: A total of 81 cases (eight males and 73 females; mean age at surgery 14.4 years) were enrolled. The mean preoperative Cobb angle was 51.0°. The Cronbach α coefficient for the overall SRS-30 was 0.861, indicating high internal consistency, while the coefficients for each domain were as follows: function/activity, 0.697; pain, 0.405; self-image/appearance, 0.776; mental health, 0.845; and satisfaction, 0.559. The SRS-30 total score significantly correlated with the SRS-22r total (r=0.945, P<0.001) and the ODI (r=-0.511, P<0.001). The SRS-30 domains highly correlated with the corresponding SRS-22r domains, with correlations ranging from r=0.826 to 0.901 (all P<0.001)., Conclusions: The Japanese version of the SRS-30 demonstrated good internal and external validity. The SRS-30 can be used as an assessment tool for health-related quality of life in AIS patients., Competing Interests: Conflicts of Interest: The authors declare that there are no relevant conflicts of interest., (Copyright © 2024 The Japanese Society for Spine Surgery and Related Research.)

Published
2024
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31. Instrumentation failure following pediatric spine deformity growth-sparing surgery using traditional growing rods or vertical expandable prosthetic titanium ribs.

Author

Yokogawa N, Demura S, Ohara T, Tauchi R, Takimura K, Yanagida H, Yamaguchi T, Watanabe K, Suzuki S, Uno K, Suzuki T, Watanabe K, Kotani T, Nakayama K, Oku N, Taniguchi Y, Murakami H, Yamamoto T, Kawamura I, Takeshita K, Sugawara R, Kikkawa I, and Kawakami N

Subjects
Child, Humans, Titanium, Prostheses and Implants adverse effects, Ribs surgery, Ribs abnormalities, Reoperation, Postoperative Complications epidemiology, Postoperative Complications etiology, Postoperative Complications surgery, Spine diagnostic imaging, Spine surgery, Spine abnormalities, Retrospective Studies, Treatment Outcome, Multicenter Studies as Topic, Scoliosis surgery, Scoliosis diagnosis
Abstract

Background: Instrumentation failure (IF) is a major complication associated with growth-sparing surgery for pediatric spinal deformities; however, studies focusing on IF following each surgical procedure are lacking. We aimed to evaluate the incidence, timing, and rates of unplanned return to the operating room (UPROR) associated with IF following each surgical procedure in growth-sparing surgeries using traditional growing rods (TGRs) and vertical expandable prosthetic titanium ribs (VEPTRs)., Methods: We reviewed 1,139 surgical procedures documented in a Japanese multicenter database from 2015 to 2017. Of these, 544 TGR and 455 VEPTR procedures were included for evaluation on a per-surgery basis. IF was defined as the occurrence of an implant-related complication requiring revision surgery., Results: The surgery-based incidences of IF requiring revision surgery in the TGR and VEPTR groups were 4.3% and 4.0%, respectively, with no significant intergroup difference. Remarkably, there was a negative correlation between IF incidence per surgical procedure and the number of lengthening surgeries in both groups. In addition, rod breakage in the TGR group and anchor-related complications in the VEPTR group tended to occur relatively early in the treatment course. The surgery-based rates of UPROR due to IF in the TGR and VEPTR groups were 2.0% and 1.5%, respectively, showing no statistically significant difference., Conclusions: We found that IF, such as anchor related-complications and rod breakage, occurs more frequently earlier in the course of lengthening surgeries. This finding may help in patient counseling and highlights the importance of close postoperative follow-up to detect IF and improve outcomes., (© 2024. The Author(s).)

Published
2024
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33. Expression analysis of type I ARF small GTPases ARF1-3 during mouse brain development.

Author

Matsuki T, Hamada N, Ito H, Sugawara R, Iwamoto I, Nakayama A, and Nagata KI

Subjects
Animals, Mice, ADP-Ribosylation Factors genetics, Neurons, Axons, Cerebellum, Monomeric GTP-Binding Proteins
Abstract

Background: ARF (ADP-ribosylation factor) GTPases are major regulators of intracellular trafficking, and classified into 3 groups (Type I - III), among which the type I group members, ARF1 and 3, are responsible genes for neurodevelopmental disorders., Methods: In this study, we analysed the expression of Type I ARFs ARF1-3 during mouse brain development using biochemical and morphological methods., Results: Western blotting analyses revealed that ARF1-3 are weakly expressed in the mouse brain at embryonic day 13 and gradually increase until postnatal day 30. ARF1-3 appear to be abundantly expressed in various telencephalon regions. Biochemical fractionation studies detected ARF1-3 in the synaptosome fraction of cortical neurons containing both pre- and post-synapses, however ARF1-3 were not observed in post-synaptic compartments. In immunohistochemical analyses, ARF1-3 appeared to be distributed in the cytoplasm and dendrites of cortical and hippocampal neurons as well as in the cerebellar molecular layer including dendrites of Purkinje cells and granule cell axons. Immunofluorescence in primary cultured hippocampal neurons revealed that ARF1-3 are diffusely distributed in the cytoplasm and dendrites with partial colocalization with a pre-synaptic marker, synaptophysin., Conclusions: Overall, our results support the notion that ARF1-3 could participate in vesicle trafficking both in the dendritic shaft (excluding spines) and axon terminals (pre-synaptic compartments)., (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)

Published
2024
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34. COVID-19 Developed During Systemic Steroid Therapy for Vogt-Koyanagi-Harada Disease: A Case Report.

Author

Niidome S, Usui Y, Tsubota K, Sugawara R, and Goto H

Subjects
Female, Humans, Adult, SARS-CoV-2, Steroids therapeutic use, Uveomeningoencephalitic Syndrome complications, Uveomeningoencephalitic Syndrome diagnosis, Uveomeningoencephalitic Syndrome drug therapy, COVID-19, Uveitis diagnosis, Uveitis drug therapy
Abstract

Purpose: The use of immunomodulatory therapy in the setting of coexistence of uveitis and coronavirus disease (COVID-19) remains controversial. We report a case of COVID-19 during systemic steroid therapy for Vogt-Koyanagi-Harada disease (VKH)., Case Report: A 43-year-old female was diagnosed with VKH and started on steroid pulse therapy (1,000 mg/day) followed by high-dose oral corticosteroids. Two weeks after discharge from the hospital, she was readmitted to the intensive care unit with severe acute respiratory syndrome due to SARS-CoV-2 infection confirmed by PCR test, and fortunately both VKH and COVID-19-induced respiratory disease improved., Conclusion: Given the absence of international agreement on how to manage COVID-19 patients with steroid-dependent VKH, existing clinical guidelines should be reviewed thoroughly to formulate useful strategies for managing VKH patients on steroid treatment who contract COVID-19. Furthermore, the outcomes of patients with steroid-dependent autoimmune uveitis including VKH who develop COVID-19 should be analyzed.

Published
2023
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35. A new species of the genus Aleurodiscus sensu lato ( Russulales, Basidiomycota ) from Hachijo Island, Japan.

Author

Maekawa N, Sugawara R, Nakano R, Shino R, Sotome K, Nakagiri A, and Oba Y

Abstract

Aleurodiscus sagittisporus sp. nov. is described and illustrated. This species is characterized by producing basidiomata with a monomitic hyphal system, clampless-septate hyphae, arrowhead-shaped, amyloid, finely verrucose basidiospores, gloeocystidia, dendrohyphidium-like branched paraphysoid hyphae, and variously shaped swelling cells in the hymenium. Phylogenetic analyses based on nuclear rDNA LSU and ITS sequences revealed that the species is distinct from the lineage of Aleurodiscus s. str. and related genera in the Aleurodiscus s. lat. clade. Basidiomata of A. sagittisporus have been collected only from dead petioles attached to living trees of Livistona chinensis var. subglobosa on Hachijo Island, Japan., (2023, by The Mycological Society of Japan.)

Published
2023
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36. COVID-19 in Patients with Pre-Existing Interstitial Lung Disease: Potential Value of a Steroid-Based Treatment Strategy.

Author

Arai T, Kurahara Y, Moda M, Kobayashi T, Matsuda Y, Kagawa T, Sugawara R, Tsuyuguchi K, and Inoue Y

Abstract

The prognosis of patients with coronavirus disease 2019 (COVID-19) and pre-existing interstitial lung disease (preILD) is poor, and no effective treatment strategy has been determined. The aim of this study was to assess the effectiveness of a steroid-based treatment strategy for patients with COVID-19 and preILD. We retrospectively reviewed the medical records of 610 consecutive patients with COVID-19 treated at our institution between 1 March 2020 and 30 October 2021 and identified 7 patients with preILD, all of whom were treated with corticosteroids and remdesivir. All the patients were men with a median age of 63 years. Three of four patients with severe disease required invasive positive-pressure ventilation ( n = 2) or nasal high-flow therapy ( n = 1). All three patients could be weaned from respiratory support; however, one died in hospital. The remaining patient with severe COVID-19 had a do-not-resuscitate order in place and died while hospitalized. All three patients with moderate COVID-19 were discharged. The 30-day mortality was 0%, and the mortality rate during the entire observation period was 28.5%. The prognosis of our patients with COVID-19 and preILD has been better than in previous reports. Our management strategy using corticosteroids may have improved these patients' prognosis.

Published
2023
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37. Evidence of causality of low body mass index on risk of adolescent idiopathic scoliosis: a Mendelian randomization study.

Author

Otomo N, Khanshour AM, Koido M, Takeda K, Momozawa Y, Kubo M, Kamatani Y, Herring JA, Ogura Y, Takahashi Y, Minami S, Uno K, Kawakami N, Ito M, Sato T, Watanabe K, Kaito T, Yanagida H, Taneichi H, Harimaya K, Taniguchi Y, Shigematsu H, Iida T, Demura S, Sugawara R, Fujita N, Yagi M, Okada E, Hosogane N, Kono K, Nakamura M, Chiba K, Kotani T, Sakuma T, Akazawa T, Suzuki T, Nishida K, Kakutani K, Tsuji T, Sudo H, Iwata A, Inami S, Wise CA, Kochi Y, Matsumoto M, Ikegawa S, Watanabe K, and Terao C

Subjects
Adolescent, Humans, Body Mass Index, Mendelian Randomization Analysis, Polymorphism, Single Nucleotide, Genome-Wide Association Study, Scoliosis epidemiology, Scoliosis genetics
Abstract

Introduction: Adolescent idiopathic scoliosis (AIS) is a disorder with a three-dimensional spinal deformity and is a common disease affecting 1-5% of adolescents. AIS is also known as a complex disease involved in environmental and genetic factors. A relation between AIS and body mass index (BMI) has been epidemiologically and genetically suggested. However, the causal relationship between AIS and BMI remains to be elucidated., Material and Methods: Mendelian randomization (MR) analysis was performed using summary statistics from genome-wide association studies (GWASs) of AIS (Japanese cohort, 5,327 cases, 73,884 controls; US cohort: 1,468 cases, 20,158 controls) and BMI (Biobank Japan: 173430 individual; meta-analysis of genetic investigation of anthropometric traits and UK Biobank: 806334 individuals; European Children cohort: 39620 individuals; Population Architecture using Genomics and Epidemiology: 49335 individuals). In MR analyses evaluating the effect of BMI on AIS, the association between BMI and AIS summary statistics was evaluated using the inverse-variance weighted (IVW) method, weighted median method, and Egger regression (MR-Egger) methods in Japanese., Results: Significant causality of genetically decreased BMI on risk of AIS was estimated: IVW method (Estimate (beta) [SE] = -0.56 [0.16], p = 1.8 × 10 -3 ), weighted median method (beta = -0.56 [0.18], p = 8.5 × 10 -3 ) and MR-Egger method (beta = -1.50 [0.43], p = 4.7 × 10 -3 ), respectively. Consistent results were also observed when using the US AIS summary statistic in three MR methods; however, no significant causality was observed when evaluating the effect of AIS on BMI., Conclusions: Our Mendelian randomization analysis using large studies of AIS and GWAS for BMI summary statistics revealed that genetic variants contributing to low BMI have a causal effect on the onset of AIS. This result was consistent with those of epidemiological studies and would contribute to the early detection of AIS., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Otomo, Khanshour, Koido, Takeda, Momozawa, Kubo, Kamatani, Herring, Ogura, Takahashi, Minami, Uno, Kawakami, Ito, Sato, Watanabe, Kaito, Yanagida, Taneichi, Harimaya, Taniguchi, Shigematsu, Iida, Demura, Sugawara, Fujita, Yagi, Okada, Hosogane, Kono, Nakamura, Chiba, Kotani, Sakuma, Akazawa, Suzuki, Nishida, Kakutani, Tsuji, Sudo, Iwata, Inami, Wise, Kochi, Matsumoto, Ikegawa, Watanabe and Terao.)

Published
2023
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38. Selection Bias in Avoiding Vein Graft in Replantation/Revascularization May Exist in Distal and Proximal Amputations, Respectively.

Author

Kobayashi K, Shinoura S, Nishimura K, and Sugawara R

Abstract

No difference in the success rate has been reported between the vein graft and non-vein graft groups in replantation/revascularization. However, this depends on a wide range of indications in difficult cases. This study aimed to investigate the selection bias in avoiding vein grafts., Methods: This is a single-center, noninterventional, retrospective cohort study comprising 229 patients (277 digits) who underwent replantation/revascularization between January 2000 and December 2020 at our institution. Sex, age, smoking history, comorbidities, affected side, level of amputation, complete or incomplete amputation, type of fracture and mechanism, diameter of the artery, needle, warm ischemic time, and results were investigated and compared between the subgroups with and without vein graft. Results were investigated between the subgroups with and without a vein graft in the distal and proximal groups., Results: In the distal group, the mean arterial diameter of the vein graft subgroup was larger than that of the non-vein graft subgroup [0.7 (0.1) mm and 0.6 (0.2) mm, respectively, P < 0.05]. In the proximal group, the vein graft subgroup had higher severity than the non-vein graft subgroup (comminuted fracture, 31.1% versus 13.4%; and avulsion or crush amputation, 57.8% versus 37.1%, respectively, P < 0.05). However, the success rate was not significantly different between the aforementioned subgroups., Conclusion: There was no significant difference between the vein graft and non-vein graft subgroups owing to the selection bias avoiding small arteries in the distal amputation and the absence of said bias in the proximal amputation., Competing Interests: The authors have no financial interest to declare in relation to the content of this article., (Copyright © 2023 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons.)

Published
2023
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39. Clinical features of primary vitreoretinal lymphoma developing extra-central nervous system (CNS)/testicular lymphomas with or without CNS involvement: A single-centre study of 13 cases.

Author

Kunimi K, Usui Y, Sugawara R, Asakage M, Tsubota K, Gotoh A, and Goto H

Subjects
Humans, Vitreous Body pathology, Central Nervous System pathology, Retinal Neoplasms diagnosis, Retinal Neoplasms pathology, Central Nervous System Neoplasms diagnosis, Central Nervous System Neoplasms etiology, Central Nervous System Neoplasms pathology, Lymphoma pathology, Lymphoma, Non-Hodgkin pathology
Published
2023
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40. Mid-lateral approach for revascularization of an amputated second toe: A case report.

Author

Nishimura K, Fukasawa K, Sugawara R, and Kobayashi K

Abstract

The plantar or dorsal approach has been previously reported for the replantation or revascularization of a completely or incompletely amputated lesser toe. However, no reports exist describing an alternative approach for the replantation or revascularization of an amputated lesser toe, either complete or incomplete. We encountered a rare case of revascularization of an incompletely amputated second toe using a mid-lateral approach. The purpose of this case report was to describe the mid-lateral approach, which is novel in its nature for the replantation or revascularization of a completely or incompletely amputated lesser toe. A 43-year-old male was involved in a motor vehicle accident and had incomplete crush amputation of a second toe at the base of the nail, along with open dislocation of the distal interphalangeal (DIP) joint in the third toe. We performed artery-only revascularization of the second toe using a mid-lateral approach, with the patient in the supine position with his hip in flexion and external rotation. The postoperative course was uneventful, and the second toe was deemed viable. The Japanese Society for Surgery of the Foot (JSSF) standard rating system of the lesser toe was rated 90 and the Self-Administered Foot Evaluation Questionnaire (SAFE-Q) scored 100 in all the mentioned categories. The mid-lateral approach could be an option for the replantation or revascularization of an amputated lesser toe distal to the proximal interphalangeal (PIP) joint., Competing Interests: The authors have no conflicts of interest to declare., (© 2023 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.)

Published
2023
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41. Handgrip strength is correlated with activities of daily living, balance, and body composition in patients with thoracolumbar compression fracture.

Author

Inoue H, Hayashi Y, Watanabe H, Sawamura H, Shiraishi Y, Sugawara R, Kimura A, Masubuchi M, and Takeshita K

Subjects
Aged, Male, Humans, Female, Aged, 80 and over, Hand Strength, Activities of Daily Living, Cross-Sectional Studies, Body Composition, Fractures, Compression, Sarcopenia diagnosis, Spinal Fractures
Abstract

This study assessed the relationship between handgrip strength (HGS) and activities of daily living, balance, walking speed, calf circumference, body muscle, and body composition in elderly patients with thoracolumbar vertebral compression fracture (VCF). A cross-sectional study in a single hospital was performed with elderly patients diagnosed with VCF. After admission, we evaluated HGS, 10-meter walk test (speed), Barthel Index, Berg Balance Scale (BBS), numerical rating scale of body pain, and calf circumference. We examined skeletal muscle mass, skeletal muscle mass index, total body water (TBW), intracellular water, extracellular water (ECW), and phase angle (PhA) in patients with VCF using multi-frequency direct segmental bioelectrical impedance analysis after admission. A total of 112 patients admitted for VCF were enrolled (26 males, 86 females; mean age 83.3 years). The prevalence of sarcopenia according to the 2019 Asian Working Group for Sarcopenia guideline was 61.6%. HGS was significantly correlated with walking speed (P < .001, R = 0.485), Barthel Index (P < .001, R = 0.430), BBS (P < .001, R = 0.511), calf circumference (P < .001, R = 0.491), skeletal muscle mass index (P < .001, R = 0.629), ECW/TBW (P < .001, r = -0.498), and PhA (P < .001, R = 0.550). HGS was more strongly correlated with walking speed, Barthel Index, BBS, ECW/TBW ratio, and PhA in men than women. In patients with thoracolumbar VCF, HGS is associated with walking speed, muscle mass, activities of daily living measured using the Barthel Index, and balance measured using BBS. The findings suggest that HGS is an important indicator of activities of daily living, balance, and whole-body muscle strength. Furthermore, HGS is related to PhA and ECW/TBW., Competing Interests: The authors have no funding and conflicts of interests to disclose., (Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.)

Published
2023
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42. Hypochnicium sensu lato ( Polyporales , Basidiomycota ) from Japan, with descriptions of a new genus and three new species.

Author

Maekawa N, Sugawara R, Kogi H, Norikura S, Sotome K, Endo N, Nakagiri A, and Ushijima S

Abstract

Species of Hypochnicium ( Polyporales , Basidiomycota ) collected from Japan were studied on their taxonomy by morphological and phylogenetic approaches. Phylogenetic analyses based on a nrDNA LSU and ITS dataset including the Japanese specimens and other publicly available ones show that Hypochnicium is polyphyletic. Since the clade containing the type species H. bombycinum was well-supported, we defined this clade as Hypochnicium s. str., and emended Hypochnicium to include restricted taxa with only smooth basidiospores. The new genus Neohypochnicium is proposed to accommodate the remaining taxa excluded from the genus Hypochnicium s. str., which includes both species with smooth basidiospores and ornamented ones. Three new species, Gyrophanopsis japonica , N. asiaticum and N. perlongicystidiosum are described and illustrated based on morphological and phylogenetic analyses using an ITS region dataset. In addition, the following 15 new combinations are proposed: N. albostramineum , N. aotearoae , N. capitulateum , N. cremicolor , N. cystidiatum , N. geogenium , N. guineense , N. huinayense , N. michelii , N. microsporum , N. patagonicum , N. pini , N. punctulatum , N. subrigescens and N. wakefieldiae . An identification key to Japanese species of Bulbillomyces , Gyrophanopsis , Hypochnicium and Neohypochnicium is provided., (2023, by The Mycological Society of Japan.)

Published
2023
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43. Identification of a Functional Susceptibility Variant for Adolescent Idiopathic Scoliosis that Upregulates Early Growth Response 1 (EGR1)-Mediated UNCX Expression.

Author

Yonezawa Y, Guo L, Kakinuma H, Otomo N, Yoshino S, Takeda K, Nakajima M, Shiraki T, Ogura Y, Takahashi Y, Koike Y, Minami S, Uno K, Kawakami N, Ito M, Yonezawa I, Watanabe K, Kaito T, Yanagida H, Taneichi H, Harimaya K, Taniguchi Y, Shigematsu H, Iida T, Demura S, Sugawara R, Fujita N, Yagi M, Okada E, Hosogane N, Kono K, Chiba K, Kotani T, Sakuma T, Akazawa T, Suzuki T, Nishida K, Kakutani K, Tsuji T, Sudo H, Iwata A, Sato T, Inami S, Nakamura M, Matsumoto M, Terao C, Watanabe K, Okamoto H, and Ikegawa S

Subjects
Animals, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide genetics, Transcription Factors genetics, Zebrafish genetics, Genome-Wide Association Study, Scoliosis genetics
Abstract

Adolescent idiopathic scoliosis (AIS) is a serious health problem affecting 3% of live births all over the world. Many loci associated with AIS have been identified by previous genome wide association studies, but their biological implication remains mostly unclear. In this study, we evaluated the AIS-associated variants in the 7p22.3 locus by combining in silico, in vitro, and in vivo analyses. rs78148157 was located in an enhancer of UNCX, a homeobox gene and its risk allele upregulated the UNCX expression. A transcription factor, early growth response 1 (EGR1), transactivated the rs78148157-located enhancer and showed a higher binding affinity for the risk allele of rs78148157. Furthermore, zebrafish larvae with UNCX messenger RNA (mRNA) injection developed body curvature and defective neurogenesis in a dose-dependent manner. rs78148157 confers the genetic susceptibility to AIS by enhancing the EGR1-regulated UNCX expression. © 2022 American Society for Bone and Mineral Research (ASBMR)., (© 2022 American Society for Bone and Mineral Research (ASBMR).)

Published
2023
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44. Exogenous Lipoid Pneumonia Caused by Gargling With Sesame Oil: A Case Report.

Author

Yamada A, Kagawa T, Nishimoto Y, Sugawara R, Arai T, Inoue Y, Taiji R, Okada H, Takewa M, Sugimura H, and Tanaka T

Subjects
Humans, Tomography, X-Ray Computed adverse effects, Sesame Oil therapeutic use, Pneumonia, Lipid chemically induced, Pneumonia, Lipid diagnostic imaging
Abstract

Competing Interests: The authors declare no conflicts of interest.

Published
2022
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45. Incidence and causes of instrument-related complications after primary definitive fusion for pediatric spine deformity.

Author

Demura S, Ohara T, Tauchi R, Takimura K, Watanabe K, Suzuki S, Uno K, Suzuki T, Yanagida H, Yamaguchi T, Kotani T, Nakayama K, Watanabe K, Yokogawa N, Oku N, Tsuchiya H, Yamamoto T, Kawamura I, Taniguchi Y, Takeshita K, Sugawara R, Kikkawa I, Sato T, Fujiwara K, Akazawa T, Murakami H, and Kawakami N

Subjects
Humans, Child, Male, Female, Adolescent, Incidence, Retrospective Studies, Lumbar Vertebrae surgery, Postoperative Complications epidemiology, Postoperative Complications etiology, Treatment Outcome, Scoliosis surgery, Scoliosis complications, Pedicle Screws adverse effects, Spinal Fusion adverse effects, Spinal Fusion methods
Abstract

Objective: Various complications have been reported in the treatment of pediatric spinal deformities. Among these, instrument-related complications could be critical concerns and risks of reoperation. This study aimed to identify the incidence and causes of complications after primary definitive fusion for pediatric spine deformities., Methods: The authors retrospectively collected data from 14 institutions about patients who underwent primary definitive fusion between 2015 and 2017. There were 1490 eligible patients (1184 female and 306 male), with a mean age of 13.9 years. The incidence, causes, and reoperation rates were analyzed according to 4 etiologies of pediatric spine deformity (congenital, neuromuscular, syndromic, idiopathic). The complications were also categorized as screw-, hook-, or rod-related complications, implant loosening or backout, and junctional problems., Results: The incidence of overall instrument-related complications was 5.6% (84 cases). Regarding etiology, the incidence rates were 4.3% (idiopathic), 6.8% (syndromic), 7.9% (congenital), and 10.4% (neuromuscular) (p < 0.05). The most common causes were pedicle screw malposition (60.7%), followed by implant backout or loosening (15.4%), junctional problems (13.1%), rod breakage (4.8%), and other complications (6.0%). Univariate analysis showed that etiology, type of deformity (kyphosis), surgical procedure, operation time, and estimated blood loss were significant factors. Multivariate analysis revealed that etiology (neuromuscular), surgical procedure (combined approach), and operation time (> 5 hours) remained as significant risk factors. Among all patients with instrument-related complications, 45% (38/84) required revision surgery. Of these cases, > 50% were related to pedicle screw malposition. Medial breach was the most common complication regardless of location, from upper thoracic to lumbar spine., Conclusions: Pedicle screw malposition was the primary cause of overall complications and subsequent reoperation. In addition to more precise screw insertion techniques, meticulous confirmation of pedicle screw placement, especially of medial breach, may reduce the overall instrument-related complications and revision rates.

Published
2022
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46. Predictors of Postoperative Delirium in Older Patients Undergoing Elective Spine Surgery.

Author

Kimura A, Shiraishi Y, Sawamura H, Sugawara R, Inoue H, and Takeshita K

Abstract

Introduction: This prospective study was conducted to investigate the prevalence and predictors of postoperative delirium (POD) in a cohort of patients aged ≥65 years who were scheduled to undergo elective spine surgery., Methods: Patients aged ≥65 years who were scheduled to undergo elective spine surgery from February 2018 to May 2019 were prospectively recruited for this study. Delirium was diagnosed according to the Confusion Assessment Method algorithm. Candidate predictors included patient characteristics, comorbidities, surgical time, blood loss, preoperative laboratory parameters, and preoperative cognitive function, as assessed by the Mini-Cog test. These variables were compared between patients with and without POD. Multivariate logistic regression was performed to identify the independent predictors of POD. For the continuous variables, a receiver operating characteristic curve was used to determine the optimal cutoff value for predicting POD., Results: Of the 106 patients included in the study, 12 (11.3%) patients developed POD, with a median time to onset of 3 d and median duration of 2 d. After adjusting for confounders, the occurrence of POD was independently associated with older age, a higher blood urea nitrogen (BUN) concentration, and a lower Mini-Cog score. The optimal cutoff point of the Mini-Cog score for predicting the occurrence of POD was ≤3., Conclusions: POD was a common complication after spine surgery, showing an incidence of 11.3% in this study. Older age, a higher BUN concentration, and impaired cognition, as defined by the Mini-Cog, were independent predictors of POD. The current results may be useful for early identification of patients at risk of POD and facilitation of targeted interventions for preventing POD or mitigating its severity., Competing Interests: Conflicts of Interest: The authors declare that there are no relevant conflicts of interest., (Copyright © 2023 The Japanese Society for Spine Surgery and Related Research.)

Published
2022
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47. Reconstruction of Dexterous 3D Motion Data From a Flexible Magnetic Sensor With Deep Learning and Structure-Aware Filtering.

Author

Huang J, Sugawara R, Chu K, Komura T, and Kitamura Y

Subjects
Computer Graphics, Magnetic Phenomena, Motion, Neural Networks, Computer, Deep Learning
Abstract

We propose IM3D+, a novel approach to reconstructing 3D motion data from a flexible magnetic flux sensor array using deep learning and a structure-aware temporal bilateral filter. Computing the 3D configuration of markers (inductor-capacitor (LC) coils) from flux sensor data is difficult because the existing numerical approaches suffer from system noise, dead angles, the need for initialization, and limitations in the sensor array's layout. We solve these issues with deep neural networks to learn the regression from the simulation flux values to the LC coils' 3D configuration, which can be applied to the actual LC coils at any location and orientation within the capture volume. To cope with the influence of system noise and the dead-angle limitation caused by the characteristics of the hardware and sensing principle, we propose a structure-aware temporal bilateral filter for reconstructing motion sequences. Our method can track various movements, including fingers that manipulate objects, beetles that move inside a vivarium with leaves and soil, and the flow of opaque fluid. Since no power supply is needed for the lightweight wireless markers, our method can robustly track movements for a very long time, making it suitable for various types of observations whose tracking is difficult with existing motion-tracking systems. Furthermore, the flexibility of the flux sensor layout allows users to reconfigure it based on their own applications, thus making our approach suitable for a variety of virtual reality applications.

Published
2022
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48. Two new species of Sistotrema s.l. ( Cantharellales ) from Japan with descriptions of their ectomycorrhizae.

Author

Sugawara R, Shirasuka N, Yamamoto T, Nagamune K, Oguchi K, Maekawa N, Sotome K, Nakagiri A, Ushijima S, and Endo N

Abstract

We describe two new species of resupinate Sistotrema sensu lato ( Cantharellales ) collected in Japan: S. flavorhizomorphae and S. chloroporum . Both species have urniform basidia with more than four sterigmata and monomitic hyphal system, oil-rich hyphae in subiculum, which is typical for this genus. Sistotrema chloroporum is characterized by poroid hymenophore partly yellowish-green, basidia 4-6-spored, medium-sized basidiospores (4.5-6.5 × 3.5-6 µm), and broadleaf forest habitat. Sistotrema flavorhizomorphae is characterized by hydnoid-irpicoid hymenophore, bright yellowish rhizomorphs, basidia 6-8-spored, small basidiospores (3-3.5 × 2.5-3 µm), and pine forest habitat. Phylogenetic trees inferred from the fungal nrDNA ITS and LSU and the rpb2 sequences supported that both species were distinct and grouped with other ectomycorrhizal Sistotrema and Hydnum species, but their generic boundary was unclear. Mycorrhizae underneath basidiomes of both species were identified and described via molecular techniques. Mycorrhizae of S. chloroporum have similar characteristics to those of other Sistotrema s.l. and Hydnum species, i.e., S. confluens and H. repandum , whereas S. flavorhizomorphae has a distinct morpho-anatomy, for example, a distinct pseudoparenchymatous mantle. Comprehensive characterizations of basidiomes and mycorrhizae improve the taxonomic analysis of mycorrhizal species of Sistotrema s.l., (2022, by The Mycological Society of Japan.)

Published
2022
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49. Systematic revision of Hydnum species in Japan.

Author

Sugawara R, Maekawa N, Sotome K, Nakagiri A, and Endo N

Subjects
DNA, Fungal genetics, DNA, Ribosomal genetics, DNA, Ribosomal Spacer genetics, Japan, Phylogeny, RNA, Ribosomal, 5.8S genetics, Sequence Analysis, DNA, Basidiomycota genetics
Abstract

Hydnum (Hydnaceae, Basidiomycota) exhibits endemic species diversity in East Asia; however, few comprehensive systematic studies have been conducted to date. Here, we performed morphological, ecological, phylogenetic, and biological evaluations of the taxonomy of Hydnum species in Japan. In total, 186 Japanese Hydnum specimens were used for morphological observations. Phylogenetic trees were constructed using sequence data of nuc rDNA internal transcribed spacer ITS1-5.8S-ITS2 (ITS) region and a portion of translation elongation factor 1-α ( tef1 ). Intra- and interspecific mating tests using 78 monokaryotic strains of 13 species did not conflict with species delimitation inferred from their ITS and tef1 phylogenetic relationships. This study provides detailed morphological descriptions of 15 rigorously identified species from Japan, nine of which are described as new: H. alboluteum, H. albopallidum, H. pinicola, H. itachiharitake, H. minospororufescens, H. orientalbidum, H. subberkeleyanum, H. tomaense , and H. tottoriense . Three species documented in this work are new to Japan: H. boreorepandum, H. mulsicolor , and H. umbilicatum . The remaining three species ( H. cremeoalbum, H. minus , and H. repando-orientale ), previously reported from Japan, are redescribed using data from newly collected materials. We also transferred two old species ( Hericium fimbrillatum and Sarcodon nauseofoetidus ) from East Asian Hydnum into other genera.

Published
2022
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50. A case of conjunctival precursor T cell lymphoblastic lymphoma presenting with salmon colored conjunctival mass.

Author

Sugawara R, Usui Y, Takahashi R, Nagao T, and Goto H

Abstract

Purpose: T-Lymphoblastic lymphoma (T-LBL) is a rare malignant tumor originated from precursor T-lymphocytes that differentiate to T lymphocytes. We report a rare case of T-LBL presenting with conjunctival mass as the first sign., Observations: A 61-year-old man presented with a right salmon colored conjunctival mass. A biopsy was performed, and histopathologic examination showed dense lymphocyte proliferation in subepithelial substantia propria. Immunohistochemical staining was positive for CD7, CD10, and TdT; and negative for CD20. CD3 was negative in most parts PET-CT revealed abnormal uptake in the left cervix, anterior mediastinum, abdominal aortic lymph nodes, and multiple bones. From the above findings, stage IVA T-LBL was diagnosed. The patient received hyper CVAD therapy (cyclophosphamide + doxorubicin + vincristine + dexamethasone) and HD-MA therapy (high-dose methotrexate + cytarabine). Subsequently, an unrelated bone marrow transplant was performed., Conclusions and Importance: This case demonstrates the importance of considering rare lymphomas such as T-LBL in the differential diagnosis of ocular adnexal lymphoid neoplasms., Competing Interests: The authors declared no potential conflicts of interests with respect to the research, authorship, and/or publication of this article., (© 2022 The Authors.)

Published
2022
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