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515 results on '"Struck, Joachim"'

1. Activity of the adrenomedullin system to personalise post-discharge diuretic treatment in acute heart failure

Author

Kozhuharov, Nikola, Ng, Leong, Wussler, Desiree, Strebel, Ivo, Sabti, Zaid, Hartmann, Oliver, Eltayeb, Mohamed, Squire, Iain, Nowak, Albina, Rieger, Max, Martin, Jasmin, Michou, Eleni, Stefanelli, Sabrina, Puelacher, Christian, Shrestha, Samyut, Belkin, Maria, Zimmermann, Tobias, Lopez-Ayala, Pedro, Struck, Joachim, Bergmann, Andreas, Mebazaa, Alexandre, Blet, Alice, Gualandro, Danielle Menosi, Breidthardt, Tobias, and Mueller, Christian

Published
2022
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3. Precursor fractions of neurotensin and enkephalin might point to molecular mechanisms of cancer risk modulation during a lifestyle-intervention in germline BRCA1/2 gene mutation carriers

Author

Grill, Sabine, Yahiaoui-Doktor, Maryam, Basrai, Maryam, Struck, Joachim, Schulte, Janin, Berling-Ernst, Anika, Engel, Christoph, Ullrich, Mirjam, Lammert, Jacqueline, Bischoff, Stephan C., Schmidt, Thorsten, Niederberger, Uwe, Chronas, Dimitrios, Rhiem, Kerstin, Schmutzler, Rita, Halle, Martin, and Kiechle, Marion

Published
2021
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7. Proenkephalin and prognosis in heart failure with preserved ejection fraction: a GREAT network study

Author

Kanagala, Prathap, Squire, Iain B., Jones, Donald J. L., Cao, Thong Huy, Chan, Daniel C. S., McCann, Gerry, Sandhu, Jatinderpal K., Quinn, Paulene A., McAdam, John, Marsh, Anna-Marie, Davies, Joan E., Struck, Joachim, Bergmann, Andreas, Sabti, Zaid, Twerenbold, Raphael, Herrmann, Thomas, Kozhuharov, Nikola, Mueller, Christian, Ng, Leong L., and On behalf of the GREAT (Global REsearch on Acute Conditions Team) Network

Published
2019
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11. Bioactive adrenomedullin (bio-ADM) is associated with endothelial dysfunction in infants and children with complex congenital heart disease undergoing open-heart surgery on cardiopulmonary bypass.

Author

Schaefer, Maike, Stein, Andreas, Ruf, Bettina, Balling, Gunter, Palm, Jonas, Simmelbauer, Andreas, Cleuziou, Julie, Sander, Michaela, Auer, Josef, Borgmann, Kristina, Struck, Joachim, Hartmann, Oliver, Schulte, Janin, Hörer, Jürgen, Tassani-Prell, Peter, Ewert, Peter, Holdenrieder, Stefan, and Wolf, Cordula M.

Subjects
CONGENITAL heart disease, CARDIOPULMONARY bypass, ENDOTHELIUM diseases, CARDIAC surgery, ADRENOMEDULLIN, CHILD patients
Abstract

Children with congenital heart disease (CHD) undergoing cardiac surgery on cardiopulmonary bypass (CPB) are at risk for systemic inflammation leading to endothelial dysfunction associated with increased morbidity. Bioactive adrenomedullin (bio-ADM) is a peptide regulating vascular tone and endothelial permeability. The aim of this study was to evaluate the dynamics of plasma bio-ADM in this patient cohort and its role in capillary leak. Plasma samples from 73 pediatric CHD patients were collected for bio-ADM measurement at five different timepoints (TP) in the pre-, intra-, and post-operative period. The primary endpoint was a net increase in bio-ADM levels after surgery on CPB. Secondary endpoints included association of bio-ADM levels with clinical signs for endothelial dysfunction. Bio-ADM levels increased after surgery on CPB from pre-operative median of 12 pg/mL (IQR [interquartile range] 12.0–14.8 pg/mL) to a maximum post-operative median of 48.8 pg/mL (IQR 34.5–69.6 pg/mL, p<0.001). Bio-ADM concentrations correlated positively with post-operative volume balance, (r=0.341; p=0.005), increased demand for vasoactive medication (duration: r=0.415; p<0.001; quantity: TP3: r=0.415, p<0.001; TP4: r=0.414, p<0.001), and hydrocortisone treatment for vasoplegia (bio-ADM median [IQR]:129.1 [55.4–139.2] pg/mL vs. 37.9 [25.2–64.6] pg/mL; p=0.034). Patients who required pleural effusion drainage revealed higher bio-ADM levels compared to those who did not (median [IQR]: 66.4 [55.4–90.9] pg/mL vs. 40.2 [28.2–57.0] pg/mL; p<0.001). Bio-ADM is elevated in children after cardiac surgery and higher levels correlate with clinical signs of capillary leakage. The peptide should be considered as biomarker for endothelial dysfunction and as potential therapeutic target in this indication. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Bioactive Adrenomedullin, Organ Support Therapies, and Survival in the Critically Ill: Results from the French and European Outcome Registry in ICU Study

Author

Lemasle, Léa, Blet, Alice, Geven, Christopher, Cherifa, Ményssa, Deniau, Benjamin, Hollinger, Alexa, Fournier, Marie-Céline, Monnet, Xavier, Rennuit, Isabelle, Darmon, Michael, Laterre, Pierre-François, Struck, Joachim, Hartmann, Oliver, Bergmann, Andreas, Mebazaa, Alexandre, and Gayat, Etienne

Published
2020
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42. Midregional fragment of proadrenomedullin, new-onset albuminuria, and cardiovascular and all-cause mortality in patients with type 2 diabetes (ZODIAC-30)

Author

Landman, Gijs W.D., van Dijk, Peter R., Drion, Iefke, van Hateren, Kornelis J.J., Struck, Joachim, Groenier, Klaas H., Gans, Rijk O.B., Bilo, Henk J.G., Bakker, Stephan J.L., and Kleefstra, Nanne

Subjects
Diabetes therapy -- Analysis, Mortality -- Netherlands -- Analysis, Type 2 diabetes -- Patient outcomes -- Analysis, Health
Abstract

OBJECTIVE The midregional fragment of proadrenomedullin (MR-proADM) is a marker of endothelial dysfunction and has been associated with a variety of diseases. Our aim was to investigate whether MR-proADM is [...]

Published
2014
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44. Novel and conventional biomarkers for prediction of incident cardiovascular events in the community

Author

Melander, Olle, Newton-Cheh, Christopher, Almgren, Peter, Hedblad, Bo, Berglund, Goran, Engstrom, Gunnar, Persson, Margaretha, Smith, J. Gustav, Magnusson, Martin, Christensson, Anders, Struck, Joachim, Morgenthaler, Nils G., Bergmann, Andreas, Pencina, Michael J., and Wang, Thomas J.

Subjects
Risk factors (Health) -- Comparative analysis, Cardiovascular diseases -- Risk factors, Biological markers -- Usage
Abstract

The study aims to investigate the benefits of novel and conventional biomarkers, as against conventional risk factors in predicting the risk of cardiovascular events. The results indicate that even though some biomarkers are useful in predicting cardiovascular events as compared with conventional risk factors, benefits of both are the same.

Published
2009

47. Oxytocin alleviates the neuroendocrine and cytokine response to bacterial endotoxin in healthy men

Author

Clodi, Martin, Vila, Greisa, Geyeregger, Rene, Riedl, Michaela, Stulnig, Thomas M., Struck, Joachim, Luger, Thomas A., and Luger, Anton

Subjects
Neuroendocrinology -- Research, Hypothalamic-pituitary-adrenal axis -- Properties, Cytokines -- Properties, Endotoxins -- Properties, Biological sciences
Abstract

Oxytocin is a hormone and neurotransmitter found to have anti-inflammatory functions in rodents. Here we used experimental bacterial endotoxinemia to examine the role of exogenous oxytocin administration on innate immune responses in humans. Ten healthy men received, in a randomized, placebo-controlled, crossover design, placebo, oxytocin, LPS, and LPS + oxytocin. Oxytocin treatment resulted in a transient or prolonged reduction of endotoxin-induced increases in plasma ACTH, cortisol, procalcitonin, TNF-[alpha], IL-1 receptor antagonist, IL-4, IL-6, macrophage inflammatory protein-1[alpha], macrophage inflammatory protein-l[beta], monocyte chemoattractant protein-1 (MCP-1), interferon-inducible protein 10, and VEGF. In vitro, oxytocin had no impact on LPS effects in releasing TNF-[alpha], IL-6, and MCP-1 in monocytes and peripheral blood mononuclear cells from healthy human donors. In summary, oxytocin decreases the neuroendocrine and cytokine activation caused by bacterial endotoxin in men, possibly due to the pharmacological modulation of the cholinergic anti-inflammatory pathway. Oxytocin might be a candidate for the therapy of inflammatory diseases and conditions associated with high cytokine and VEGF levels. neuroendocrinology; hypothalamic-pituitary-adrenal; cytokines

Published
2008

48. The influence of corticosteroids on the release of novel biomarkers in human endotoxemia

Author

Kruif, Martijn D., Lemaire, Lucienne C., Giebelen, Ida A., Struck, Joachim, Morgenthaler, Nils G., Papassotiriou, Jana, Elliott, Peter J., and Poll, Tom

Subjects
Biological markers -- Health aspects, Corticosteroids -- Dosage and administration, Sepsis -- Care and treatment, Sepsis -- Prognosis, Health care industry
Abstract

Byline: Martijn D. Kruif (1), Lucienne C. Lemaire (2), Ida A. Giebelen (1,3), Joachim Struck (4), Nils G. Morgenthaler (4), Jana Papassotiriou (4), Peter J. Elliott (5,6), Tom Poll (1,3) Keywords: Corticosteroids; Biological markers; Endotoxin; Sepsis Abstract: Objective Sepsis intervention studies need better patient stratification methods, and one way to realize this is the introduction of stable biomarkers. A set of recently developed novel biomarkers, based upon precursor-fragments of short-lived hormones, was previously shown to be increased during sepsis. However, it is not known whether these biomarkers are influenced by sepsis intervention strategies. Therefore we investigated the markers in a model of human endotoxemia intervened by increasing doses of prednisolone. Design and setting Prospective, open-label study in a specialized clinical research unit of a university hospital. Subjects Thirty-two healthy male volunteers. Interventions Subjects received prednisolone orally at doses of 0, 3, 10 or 30a-mg (na-=a-8 per group) at 2a-h before intravenous injection of Escherichia coli lipopolysaccharide (LPS) (4a-ng/kg). Blood samples were drawn during 24a-h after LPS injection. Measurements and results LPS injection caused an increase in levels of midregional pro-adrenomedullin (MR-proADM), midregional pro-atrial natriuretic peptide (MR-proANP), C-terminal pro-arginine--vasopressin (CT-proAVP) and procalcitonin (PCT). Prednisolone caused a dose dependent inhibition of MR-proADM, MR-proANP and CT-proAVP levels. Conclusions These results show that a set of novel, highly stable sepsis biomarkers was increased during human endotoxemia and was dose-dependently inhibited by corticosteroid pre-treatment. Author Affiliation: (1) Center for Experimental and Molecular Medicine, Room G2-132, Academic Medical Center, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands (2) Department of Anesthesiology, University Medical Center Utrecht, P.O. Box 85500, 3508, Utrecht, GA, The Netherlands (3) Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands (4) Research Department, Brahms AG, Neuendorfstrasse 25, 16761, Hennigsdorf/Berlin, Germany (5) CombinatoRx, Inc., 245 st., 16th floor, 02142, Cambridge, MA, USA (6) Sirtris Pharmaceuticals, 790 Memorial Drive, 02139, Cambridge, MA, USA Article History: Registration Date: 22/11/2007 Received Date: 08/06/2007 Accepted Date: 31/10/2007 Online Date: 14/12/2007 Article note: This study was supported by research funding from CombinatoRx, Inc., Cambridge, MA, USA. One of the authors (Peter J. Elliott) was employed by CombinatoRx at the time of study design and completion. Currently, he is employed elsewhere but he is still a stockholder of CombinatoRx. Joachim Struck, Nils G. Morgenthaler and Jana Papassotiriou are employed by Brahms AG, Hennigsdorf, Germany. This article is discussed in the editorial available at: http://dx.doi.org/10.1007/s00134-007-956-9.

Published
2008

49. Comparison of Midregional Pro-Atrial Natriuretic Peptide With N-Terminal Pro-B-Type Natriuretic Peptide in Predicting Survival in Patients With Chronic Heart Failure

Author

von Haehling, Stephan, Jankowska, Ewa A., Morgenthaler, Nils G., Vassanelli, Corrado, Zanolla, Luisa, Rozentryt, Piotr, Filippatos, Gerasimos S., Doehner, Wolfram, Koehler, Friedrich, Papassotiriou, Jana, Kremastinos, Dimitrios T., Banasiak, Waldemar, Struck, Joachim, Ponikowski, Piotr, Bergmann, Andreas, and Anker, Stefan D.

Published
2007
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