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6. 18F-FDG PET/CT and Radiolabeled Leukocyte SPECT/CT Imaging for the Evaluation of Cardiovascular Infection in the Multimodality Context: ASNC Imaging Indications (ASNC I2) Series Expert Consensus Recommendations From ASNC, AATS, ACC, AHA, ASE, EANM, HRS, IDSA, SCCT, SNMMI, and STS

Author

Bourque, Jamieson M., Birgersdotter-Green, Ulrika, Bravo, Paco E., Budde, Ricardo P.J., Chen, Wengen, Chu, Vivian H., Dilsizian, Vasken, Erba, Paola Anna, Gallegos Kattan, Cesia, Habib, Gilbert, Hyafil, Fabien, Khor, Yiu Ming, Manlucu, Jaimie, Mason, Pamela Kay, Miller, Edward J., Moon, Marc R., Parker, Matthew W., Pettersson, Gosta, Schaller, Robert D., Slart, Riemer H.J.A., Strom, Jordan B., Wilkoff, Bruce L., Williams, Adam, Woolley, Ann E., Zwischenberger, Brittany A., and Dorbala, Sharmila

Published
2024
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23. Loss of Independent Living in Patients Undergoing Transcatheter or Surgical Aortic Valve Replacement: A Retrospective Cohort Study

Author

Blank, Michael, Robitaille, Mark J., Wachtendorf, Luca J., Linhardt, Felix C., Ahrens, Elena, Strom, Jordan B., Azimaraghi, Omid, Schaefer, Maximilian S., Chu, Louis M., Moon, Jee-Young, Tarantino, Nicola, Nair, Singh R., Thalappilil, Richard, Tam, Christopher W., Leff, Jonathan, Di Biase, Luigi, and Eikermann, Matthias

Published
2023
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25. Effect of Four Hemoglobin Transfusion Threshold Strategies in Patients With Acute Myocardial Infarction and Anemia: A Target Trial Emulation Using MINT Trial Data.

Author

Portela, Gerard T., Carson, Jeffrey L., Swanson, Sonja A., Alexander, John H., Hébert, Paul C., Goodman, Shaun G., Steg, Philippe Gabriel, Bertolet, Marnie, Strom, Jordan B., Fergusson, Dean A., Simon, Tabassome, White, Harvey D., Cooper, Howard A., Abbott, J. Dawn, Rao, Sunil V., Chaitman, Bernard R., Fordyce, Christopher B., Lopes, Renato D., Daneault, Benoit, and Brooks, Maria M.

Subjects
RED blood cell transfusion, MYOCARDIAL infarction, ERYTHROCYTES, BLOOD transfusion, MYOCARDIAL ischemia
Abstract

The optimal hemoglobin threshold to guide red blood cell transfusion for patients with acute myocardial infarction and anemia is uncertain. This prespecified secondary analysis of the MINT (Myocardial Ischemia and Transfusion) trial, which randomly assigned patients to a liberal transfusion threshold versus a more restrictive threshold, used target trial emulation methods to compare 4 transfusion strategies to maintain patients' hemoglobin concentrations at or above thresholds of 10, 9, 8, or 7 g/dL. Visual Abstract. Effect of Four Hemoglobin Transfusion Threshold Strategies in Patients With Acute Myocardial Infarction and Anemia: The optimal hemoglobin threshold to guide red blood cell transfusion for patients with acute myocardial infarction and anemia is uncertain. This prespecified secondary analysis of the MINT (Myocardial Ischemia and Transfusion) trial, which randomly assigned patients to a liberal transfusion threshold versus a more restrictive threshold, used target trial emulation methods to compare 4 transfusion strategies to maintain patients' hemoglobin concentrations at or above thresholds of 10, 9, 8, or 7 g/dL. Background: The optimal hemoglobin threshold to guide red blood cell (RBC) transfusion for patients with acute myocardial infarction (MI) and anemia is uncertain. Objective: To estimate the efficacy of 4 individual hemoglobin thresholds (<10 g/dL [<100 g/L], <9 g/dL [<90 g/L], <8 g/dL [<80 g/L], and <7 g/dL [<70 g/L]) to guide transfusion in patients with acute MI and anemia. Design: Prespecified secondary analysis of the MINT (Myocardial Ischemia and Transfusion) trial using target trial emulation methods. (ClinicalTrials.gov: NCT02981407) Setting: 144 clinical sites in 6 countries. Participants: 3492 MINT trial participants with acute MI and a hemoglobin level below 10 g/dL. Intervention: Four transfusion strategies to maintain patients' hemoglobin concentrations at or above thresholds of 10, 9, 8, or 7 g/dL. Protocol exceptions were permitted for specified adverse clinical events. Measurements: Data from the MINT trial were leveraged to emulate 4 transfusion strategies and estimate per protocol effects on the composite outcome of 30-day death or recurrent MI (death/MI) and 30-day death using inverse probability weighting. Results: The 30-day risk for death/MI was 14.8% (95% CI, 11.8% to 18.4%) for a <10-g/dL strategy, 15.1% (CI, 11.7% to 18.2%) for a <9-g/dL strategy, 15.9% (CI, 12.4% to 19.0%) for a <8-g/dL strategy, and 18.3% (CI, 14.6% to 22.0%) for a <7-g/dL strategy. Absolute risk differences and risk ratios relative to the <10-g/dL strategy for 30-day death/MI increased as thresholds decreased, although 95% CIs were wide. Findings were similar and imprecise for 30-day death. Limitation: Unmeasured confounding may have persisted despite adjustment. Conclusion: The 30-day risks for death/MI and death among patients with acute MI and anemia seem to increase progressively with lower hemoglobin concentration thresholds for transfusion. However, the imprecision around estimates from this target trial analysis precludes definitive conclusions about individual hemoglobin thresholds. Primary Funding Source: National Heart, Lung, and Blood Institute. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Progression of frailty and cardiovascular outcomes among Medicare beneficiaries.

Author

Gong, Yusi, Song, Yang, Xu, Jiaman, Dong, Huaying, Kramer, Daniel B., Orkaby, Ariela R., Dodson, John A., and Strom, Jordan B.

Subjects
CEREBROVASCULAR disease risk factors, RISK assessment, MEDICAL care use, MYOCARDIAL infarction, RESEARCH funding, FRAIL elderly, MEDICARE, FEE for service (Medical fees), MAJOR adverse cardiovascular events, CARDIOVASCULAR diseases risk factors, DESCRIPTIVE statistics, HEART failure, RETROSPECTIVE studies, AGE distribution, ISCHEMIC stroke, SURVIVAL analysis (Biometry), CONFIDENCE intervals, DISEASE progression, COMORBIDITY, DISEASE risk factors, OLD age
Abstract

Background: Frailty is associated with adverse cardiovascular outcomes independent of age and comorbidities, yet the independent influence of frailty progression on cardiovascular outcomes remains uncertain. Methods: To determine whether frailty progression is associated with adverse cardiovascular outcomes, independent of baseline frailty and age, we evaluated all Medicare Fee‐for‐Service beneficiaries ≥65 years at cohort inception with continuous enrollment from 2003 to 2015. Linear mixed effects models, adjusted for baseline frailty and age, were used to estimate change in a validated claims‐based frailty index (CFI) over a 5‐year period. Survival analysis was used to examine frailty progression and risk of adverse health outcomes. Results: There were 8.9 million unique patients identified, mean age 77.3 ± 7.2 years, 58.7% female, 10.9% non‐White race. In total, 60% had frailty progression and 40% frailty regression over median follow‐up of 2.4 years. Compared to those with frailty regression, when adjusting for age and baseline CFI, those with frailty progression had a significantly greater risk of incident major adverse cardiovascular and cerebrovascular events (MACCE) (hazard ratio [HR] 1.31, 95% confidence interval [CI] 1.31–1.31), all‐cause mortality (HR 1.34, 95% CI 1.34–1.34), acute myocardial infarction (HR 1.08, 95% CI 1.07–1.09), heart failure exacerbation (HR 1.30, 95% CI 1.29–1.30), ischemic stroke (HR 1.14, 95% CI 1.14–1.15). There was also a graded increase in risk of each outcome with more rapid progression, as well as significantly fewer days alive at home (DAH) with more rapid progression compared to the slowest progression group (270.4 ± 112.3 vs. 308.6 ± 93.0 days, rate ratio 0.88, 95% CI 0.87–0.88, p < 0.001). Conclusions: In this large, nationwide sample of older Medicare beneficiaries, frailty progression, independent of age and baseline frailty, was associated with fewer DAH and a graded risk of MACCE, all‐cause mortality, myocardial infarction, heart failure, and ischemic stroke compared to those with frailty regression. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Moderate Aortic Valve Stenosis Is Associated With Increased Mortality Rate and Lifetime Loss: Systematic Review and Meta-Analysis of Reconstructed Time-to-Event Data of 409 680 Patients.

Author

Jacquemyn, Xander, Strom, Jordan B., Strange, Geoff, Playford, David, Stewart, Simon, Kutty, Shelby, Bhatt, Deepak L., Bleiziffer, Sabine, Grubb, Kendra J., Pellikka, Patricia A., Clavel, Marie-Annick, Pibarot, Philippe, Mentias, Amgad, Serna-Gallegos, Derek, Pompeu Sá, Michel, and Sultan, Ibrahim

Published
2024
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