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231 results on '"Stella, Barbara"'

10. Hyaluronated liposomes containing H2S-releasing doxorubicin are effective against P-glycoprotein-positive/doxorubicin-resistant osteosarcoma cells and xenografts

Author

Gazzano, Elena, Buondonno, Ilaria, Marengo, Alessandro, Rolando, Barbara, Chegaev, Konstantin, Kopecka, Joanna, Saponara, Simona, Sorge, Matteo, Hattinger, Claudia Maria, Gasco, Alberto, Fruttero, Roberta, Brancaccio, Mara, Serra, Massimo, Stella, Barbara, Fattal, Elias, Arpicco, Silvia, and Riganti, Chiara

Published
2019
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18. The first record of partial xanthochromism in big-eared opossum, Didelphis aurita (Didelphimorphia, Didelphidae).

Author

Cotts, Leonardo, Prestes, Stella Barbara Serodio, Pires, Jeferson Rocha, and Mathias, Maria da Luz

Subjects
*OPOSSUMS, *MARSUPIALS, *BIOINDICATORS, *MAMMALS, *HYPOPIGMENTATION
Abstract

Didelphis aurita is an abundant South American didelphid. Chromatic disorders are rare and scarcely known in marsupials. We report and describe the occurrence of xanthochromism (yellowish coloration) in D. aurita, being the first record of this anomaly for opossums. The emergence of the xanthochromism correlated with the anthropogenic stress in urban-sylvatic interface suggests that chromatic disorders may serve as useful bioindicators of the health of wildlife in disturbed environments. [ABSTRACT FROM AUTHOR]

Published
2023
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19. An ex vivo experimental system to track fluorescent nanoparticles inside skeletal muscle

Author

Calderan, Laura, Carton, Flavia, Andreana, Ilaria, Bincoletto, Valeria, Arpicco, Silvia, Stella, Barbara, and Malatesta, Manuela

Subjects
liposomes, bioreactor, PLGA nanoparticles, explanted muscle, intramuscular injection, liposomes, PLGA nanoparticles, bioreactor, fluorescence microscopy, explanted muscle, intramuscular injection, fluorescence microscopy
Published
2023

22. Kit paleontológico: um material didático com abordagem investigativa

Author

Lílian Paglarelli Bergqvist and Stella Barbara Serodio Prestes

Subjects
Ensino Fundamental, Material didático-instrucional, Paleontologia, Divulgação científica, Education (General), L7-991
Abstract

Neste trabalho apresentamos um kit para aulas práticas que possibilitará, aos estudantes do Ensino Fundamental, conhecer mais sobre a Paleontologia e compreender a utilidade dos fósseis para a interpretação dos ambientes pretéritos e para a datação das camadas sedimentares. A quase totalidade das escolas do Ensino Fundamental II não dispõe de material para aulas práticas sobre temas relacionados à Paleontologia. O kit consiste em réplicas de fósseis brasileiros e de uma cartilha com as informações necessárias para o desenvolvimento das atividades práticas. Com esse intuito, foram utilizadas réplicas de fósseis procedentes da Bacia de Itaboraí, no estado do Rio de Janeiro, de idade paleocênica, e um bloco de rochas da Formação Pirabas, nos estados do Maranhão, Piauí e Pará, de idade miocênica. Este material também representa uma forma de divulgar a paleontologia brasileira e desmistificar o uso de fósseis de dinossauro como recurso único no ensino e divulgação da Paleontologia.

Published
2014
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29. Freeze Drying of Polymer Nanoparticles and Liposomes Exploiting Different Saccharide-Based Approaches.

Author

Andreana, Ilaria, Bincoletto, Valeria, Manzoli, Maela, Rodà, Francesca, Giarraputo, Vita, Milla, Paola, Arpicco, Silvia, and Stella, Barbara

Subjects
LIPOSOMES, NANOPARTICLES, CRYOPROTECTIVE agents, NANOCARRIERS, FREEZING, HYALURONIC acid, POLYMERS
Abstract

Biodegradable nanocarriers represent promising tools for controlled drug delivery. However, one major drawback related to their use is the long-term stability, which is largely influenced by the presence of water in the formulations, so to solve this problem, freeze-drying with cryoprotectants has been proposed. In the present study, the influence of the freeze-drying procedure on the storage stability of poly(lactide-co-glycolide) (PLGA) nanoparticles and liposomes was evaluated. In particular, conventional cryoprotectants were added to PLGA nanoparticle and liposome formulations in various conditions. Additionally, hyaluronic acid (HA), known for its ability to target the CD44 receptor, was assessed as a cryoprotective excipient: it was added to the nanocarriers as either a free molecule or conjugated to a phospholipid to increase the interaction with the polymer or lipid matrix while exposing HA on the nanocarrier surface. The formulations were resuspended and characterized for size, polydispersity index, zeta potential and morphology. It was demonstrated that only the highest percentages of cryoprotectants allowed the resuspension of stable nanocarriers. Moreover, unlike free HA, HA-phospholipid conjugates were able to maintain the particle mean size after the reconstitution of lyophilized nanoparticles and liposomes. This study paves the way for the use of HA-phospholipids to achieve, at the same time, nanocarrier cryoprotection and active targeting. [ABSTRACT FROM AUTHOR]

Published
2023
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30. L-Carnitine Functionalization to Increase Skeletal Muscle Tropism of PLGA Nanoparticles.

Author

Andreana, Ilaria, Malatesta, Manuela, Lacavalla, Maria Assunta, Boschi, Federico, Milla, Paola, Bincoletto, Valeria, Pellicciari, Carlo, Arpicco, Silvia, and Stella, Barbara

Subjects
SKELETAL muscle, CARNITINE, CONTROLLED release drugs, TRANSMISSION electron microscopy, FACIOSCAPULOHUMERAL muscular dystrophy, MUSCULAR dystrophy, VIRAL tropism
Abstract

Muscular dystrophies are a group of rare genetic pathologies, encompassing a variety of clinical phenotypes and mechanisms of disease. Several compounds have been proposed to treat compromised muscles, but it is known that pharmacokinetics and pharmacodynamics problems could occur. To solve these issues, it has been suggested that nanocarriers could be used to allow controlled and targeted drug release. Therefore, the aim of this study was to prepare actively targeted poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) for the treatment of muscular pathologies. By taking advantage of the high affinity for carnitine of skeletal muscle cells due to the expression of Na+-coupled carnitine transporter (OCTN), NPs have been actively targeted via association to an amphiphilic derivative of L-carnitine. Furthermore, pentamidine, an old drug repurposed for its positive effects on myotonic dystrophy type I, was incorporated into NPs. We obtained monodispersed targeted NPs, with a mean diameter of about 100 nm and a negative zeta potential. To assess the targeting ability of the NPs, cell uptake studies were performed on C2C12 myoblasts and myotubes using confocal and transmission electron microscopy. The results showed an increased uptake of carnitine-functionalized NPs compared to nontargeted carriers in myotubes, which was probably due to the interaction with OCTN receptors occurring in large amounts in these differentiated muscle cells. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Nanostructured delivery systems with improved leishmanicidal activity: a critical review

Author

Bruni,Natascia, Stella,Barbara, Giraudo,Leonardo, Della Pepa,Carlo, Gastaldi,Daniela, and Dosio,Franco

Subjects
International Journal of Nanomedicine
Abstract

Natascia Bruni,1 Barbara Stella,2 Leonardo Giraudo,1 Carlo Della Pepa,2 Daniela Gastaldi,3 Franco Dosio2 1Candioli Pharmaceutical Institute Srl, Beinasco, Italy; 2Department of Drug Science and Technology, University of Turin, Turin, Italy; 3Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy Abstract: Leishmaniasis is a vector-borne zoonotic disease caused by protozoan parasites of the genus Leishmania, which are responsible for numerous clinical manifestations, such as cutaneous, visceral, and mucocutaneous leishmaniasis, depending on the site of infection for particular species. These complexities threaten 350 million people in 98 countries worldwide. Amastigotes living within macrophage phagolysosomes are the principal target of antileishmanial treatment, but these are not an easy target as drugs must overcome major structural barriers. Furthermore, limitations on current therapy are related to efficacy, toxicity, and cost, as well as the length of treatment, which can increase parasitic resistance. Nanotechnology has emerged as an attractive alternative as conventional drugs delivered by nanosized carriers have improved bioavailability and reduced toxicity, together with other characteristics that help to relieve the burden of this disease. The significance of using colloidal carriers loaded with active agents derives from the physiological uptake route of intravenous administered nanosystems (the phagocyte system). Nanosystems are thus able to promote a high drug concentration in intracellular mononuclear phagocyte system (MPS)-infected cells. Moreover, the versatility of nanometric drug delivery systems for the deliberate transport of a range of molecules plays a pivotal role in the design of therapeutic strategies against leishmaniasis. This review discusses studies on nanocarriers that have greatly contributed to improving the efficacy of antileishmaniasis drugs, presenting a critical review and some suggestions for improving drug delivery. Keywords: amphotericin B, drug delivery systems, drug targeting, human leishmaniasis, polymeric nanoparticle

Published
2017

39. Paleontological kit: a didactic material with investigative approach

Author

Lílian Paglarelli Bergqvist and Stella Barbara Serodio Prestes

Subjects
Paleontology, General Medicine, General Chemistry, Paleontologia, Archaeology, lcsh:Education (General), Instructional didactic material, Geography, Scientific dissemination, Junior High, Ensino Fundamental, Material didático-instrucional, lcsh:L7-991, Divulgação científica
Abstract

Neste trabalho apresentamos um kit para aulas práticas que possibilitará, aos estudantes do Ensino Fundamental, conhecer mais sobre a Paleontologia e compreender a utilidade dos fósseis para a interpretação dos ambientes pretéritos e para a datação das camadas sedimentares. A quase totalidade das escolas do Ensino Fundamental II não dispõe de material para aulas práticas sobre temas relacionados à Paleontologia. O kit consiste em réplicas de fósseis brasileiros e de uma cartilha com as informações necessárias para o desenvolvimento das atividades práticas. Com esse intuito, foram utilizadas réplicas de fósseis procedentes da Bacia de Itaboraí, no estado do Rio de Janeiro, de idade paleocênica, e um bloco de rochas da Formação Pirabas, nos estados do Maranhão, Piauí e Pará, de idade miocênica. Este material também representa uma forma de divulgar a paleontologia brasileira e desmistificar o uso de fósseis de dinossauro como recurso único no ensino e divulgação da Paleontologia. In this work we present a kit for laboratory classes for Junior High schools students seeking to teach them more about paleontology and the importance and usefulness of fossils to identify past environments and dating of the sedimentary layers. Almost all Junior High schools do not have satisfactory material for laboratory classes on topics related to Paleontology. The kit consists of replicas of Brazilian fossils and a booklet with the necessary information for the practical activities. For this purpose we used replicas of fossils coming from Itaboraí Basin, Rio de Janeiro state, of Paleocene age, and a block of rock from Pirabas Formation, Maranhão, Piauí and Pará States, of Miocene age. This material is also a way to spread the knowledge Brazilian paleontology and demystify the use of dinosaur fossils as the unique source of paleontological teaching and dissemination.

Published
2014

42. Uptake and intracellular fate of biocompatible nanocarriers in cycling and noncycling cells.

Author

Costanzo, Manuela, Vurro, Federica, Cisterna, Barbara, Boschi, Federico, Marengo, Alessandro, Montanari, Elita, Meo, Chiara Di, Matricardi, Pietro, Berlier, Gloria, Stella, Barbara, Arpicco, Silvia, and Malatesta, Manuela

Abstract

Aim: To elucidate whether different cytokinetic features (i.e., presence or absence of mitotic activity) may influence cell uptake and distribution of nanocarriers, in vitro tests on liposomes, mesoporous silica nanoparticles, poly(lactide-co-glycolide) nanoparticles and nanohydrogels were carried out on C2C12 murine muscle cells either able to proliferate as myoblasts (cycling cells) or terminally differentiate into myotubes (noncycling cells). Materials & methods: Cell uptake and intracellular fate of liposomes, mesoporous silica nanoparticles, poly(lactide-co-glycolide) nanoparticles and nanohydrogels were investigated by confocal fluorescence microscopy and transmission electron microscopy. Results: Nanocarrier internalization and distribution were similar in myoblasts and myotubes; however, myotubes demonstrated a lower uptake capability. Conclusion: All nanocarriers proved to be suitably biocompatible for both myoblasts and myotubes. The lower uptake capability of myotubes is probably due to different plasma membrane composition related to the differentiation process. [ABSTRACT FROM AUTHOR]

Published
2019
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44. Nanoparticles targeting pancreatic tumor

Author

Mura, S., Valetti, Sabrina, Maione, Federica, Stella, Barbara, Desmaële, D., Noiray, M., Vergnaud, J., Vauthier, C., Cattel, Luigi, Giraudo, Enrico, and Couvreur, P.

Published
2014

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