191 results on '"Spooner, Neil"'
Search Results
2. Enhancing the light yield of He:CF4 based gaseous detector
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Amaro, Fernando Domingues, Antonietti, Rita, Baracchini, Elisabetta, Benussi, Luigi, Bianco, Stefano, Campagnola, Roberto, Capoccia, Cesidio, Caponero, Michele, Cardoso, Danilo Santos, de Carvalho, Luan Gomes Mattosinhos, Cavoto, Gianluca, Costa, Igor Abritta, Croce, Antonio, Dané, Emiliano, Dho, Giorgio, Di Giambattista, Flaminia, Di Marco, Emanuele, D’Astolfo, Melba, D’Imperio, Giulia, Fiorina, Davide, Iacoangeli, Francesco, Islam, Zahoor ul, Lima Jùnior, Herman Pessoa, Kemp, Ernesto, Maccarrone, Giovanni, Mano, Rui Daniel Passos, Marcelo Gregorio, Robert Renz, Marques, David José Gaspar, Mazzitelli, Giovanni, McLean, Alasdair Gregor, Messina, Andrea, Meloni, Pietro, Monteiro, Cristina Maria Bernardes, Nobrega, Rafael Antunes, Pains, Igor Fonseca, Paoletti, Emiliano, Passamonti, Luciano, Petrucci, Fabrizio, Piacentini, Stefano, Piccolo, Davide, Pierluigi, Daniele, Pinci, Davide, Prajapati, Atul, Renga, Francesco, Roque, Rita Joana da Cruz, Rosatelli, Filippo, Russo, Alessandro, dos Santos, Joaquim Marques Ferreira, Saviano, Giovanna, Silva, Pedro Alberto Oliveira Costa, Spooner, Neil John Curwen, Tesauro, Roberto, Tomassini, Sandro, and Torelli, Samuele
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- 2024
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3. A comparison of Micromegas with [formula omitted] strip charge readouts for directional recoil detection
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Ghrear, Majd, McLean, Alasdair G., Korandla, Hima B., Dastgiri, Ferdos, Spooner, Neil J.C., and Vahsen, Sven E.
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- 2025
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4. An induced annual modulation signature in COSINE-100 data by DAMA/LIBRA’s analysis method
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Adhikari, Govinda, Carlin, Nelson, Choi, JaeJin, Choi, Seonho, Ezeribe, Anthony, França, Luis Eduardo, Ha, Chang Hyon, Hahn, In Sik, Hollick, Sophia J., Jeon, Eunju, Jo, Jay Hyun, Joo, Han Wool, Kang, Woon Gu, Kauer, Matthew, Kim, Bongho, Kim, Hongjoo, Kim, Jinyoung, Kim, Kyungwon, Kim, SungHyun, Kim, Sun Kee, Kim, Won Kyung, Kim, Yeongduk, Kim, Yong-Hamb, Ko, Young Ju, Lee, Doo Hyok, Lee, Eun Kyung, Lee, Hyunseok, Lee, Hyun Su, Lee, Hye Young, Lee, In Soo, Lee, Jaison, Lee, Jooyoung, Lee, Moo Hyun, Lee, Seo Hyun, Lee, Seung Mok, Lee, Yu Jin, Leonard, Douglas, Manzato, Bruno B., Maruyama, Reina H., Neal, Robert J., Nikkel, James A., Olsen, Stephen L., Park, Byung Ju, Park, Hyang Kyu, Park, Hyeonseo, Park, Kangsoon, Park, Se Dong, Pitta, Ricardo L. C., Prihtiadi, Hafizh, Ra, Sejin, Rott, Carsten, Shin, Keon Ah, Scarff, Andrew, Spooner, Neil J. C., Thompson, William G., Yang, Liang, and Yu, Gyun Ho
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- 2023
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5. A 50 l Cygno prototype overground characterization
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Amaro, Fernando Domingues, Antonietti, Rita, Baracchini, Elisabetta, Benussi, Luigi, Bianco, Stefano, Borra, Francesco, Capoccia, Cesidio, Caponero, Michele, Cardoso, Danilo Santos, Cavoto, Gianluca, Costa, Igor Abritta, Dané, Emiliano, Dho, Giorgio, Di Giambattista, Flaminia, Di Marco, Emanuele, D’Imperio, Giulia, dos Santos, Joaquim Marques Ferreira, di Cortona, Giovanni Grilli, Iacoangeli, Francesco, Kemp, Ernesto, Júnior, Herman Pessoa Lima, Lopes, Guilherme Sebastiao Pinheiro, Júnior, Amaro da Silva Lopes, Maccarrone, Giovanni, Mano, Rui Daniel Passos, Gregorio, Robert Renz Marcelo, Marques, David José Gaspar, Mazzitelli, Giovanni, McLean, Alasdair Gregor, Meloni, Pietro, Messina, Andrea, Monteiro, Cristina Maria Bernardes, Nobrega, Rafael Antunes, Pains, Igor Fonseca, Paoletti, Emiliano, Passamonti, Luciano, Pelosi, Sandro, Petrucci, Fabrizio, Piacentini, Stefano, Piccolo, Davide, Pierluigi, Daniele, Pinci, Davide, Prajapati, Atul, Renga, Francesco, Roque, Rita Cruz, Rosatelli, Filippo, Russo, Alessandro, Saviano, Giovanna, Spooner, Neil John Curwen, Tesauro, Roberto, Tomassini, Sandro, Torelli, Samuele, and Tozzi, Donatella
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- 2023
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6. The CYGNO experiment, a directional detector for direct Dark Matter searches
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Amaro, Fernando Domingues, Baracchini, Elisabetta, Benussi, Luigi, Bianco, Stefano, Capoccia, Cesidio, Caponero, Michele, Cardoso, Danilo Santos, Cavoto, Gianluca, Cortez, André, Costa, Igor Abritta, Dané, Emiliano, Dho, Giorgio, Di Giambattista, Flaminia, Di Marco, Emanuele, D’Imperio, Giulia, Iacoangeli, Francesco, Lima, Herman Pessoa, Jùnior, Lopes, Guilherme Sebastiao Pinheiro, Maccarrone, Giovanni, Mano, Rui Daniel Passos, Gregorio, Robert Renz Marcelo, Marques, David José Gaspar, Mazzitelli, Giovanni, McLean, Alasdair Gregor, Messina, Andrea, Monteiro, Cristina Maria Bernardes, Nobrega, Rafael Antunes, Pains, Igor Fonseca, Paoletti, Emiliano, Passamonti, Luciano, Pelosi, Sandro, Petrucci, Fabrizio, Piacentini, Stefano, Piccolo, Davide, Pierluigi, Daniele, Pinci, Davide, Prajapati, Atul, Renga, Francesco, da Cruz Roque, Rita Joanna, Rosatelli, Filippo, Russo, Alessandro, dos Santos, Joaquim Marques Ferreira, Saviano, Giovanna, Spooner, Neil John Curwen, Tesauro, Roberto, Tommasini, Sandro, and Torelli, Samuele
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- 2023
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7. LIME — A gas TPC prototype for directional Dark Matter search for the CYGNO experiment
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Amaro, Fernando Domingues, Baracchini, Elisabetta, Benussi, Luigi, Bianco, Stefano, Capoccia, Cesidio, Caponero, Michele, Cardoso, Danilo Santos, Cavoto, Gianluca, Cortez, André, Costa, Igor Abritta, Dané, Emiliano, Dho, Giorgio, Di Giambattista, Flaminia, Di Marco, Emanuele, D’Imperio, Giulia, Iacoangeli, Francesco, Júnior, Herman Pessoa Lima, Lopes, Guilherme Sebastiao Pinheiro, Maccarrone, Giovanni, Mano, Rui Daniel Passos, Gregorio, Robert Renz Marcelo, Marques, David José Gaspar, Mazzitelli, Giovanni, McLean, Alasdair Gregor, Messina, Andrea, Monteiro, Cristina Maria Bernardes, Nobrega, Rafael Antunes, Pains, Igor Fonseca, Paoletti, Emiliano, Passamonti, Luciano, Pelosi, Sandro, Petrucci, Fabrizio, Piacentini, Stefano, Piccolo, Davide, Pierluigi, Daniele, Pinci, Davide, Prajapati, Atul, Renga, Francesco, da Cruz Roque, Rita Joanna, Rosatelli, Filippo, Russo, Alessandro, dos Santos, Joaquim Marques Ferreira, Saviano, Giovanna, Spooner, Neil John Curwen, Tesauro, Roberto, Tomassini, Sandro, and Torelli, Samuele
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- 2023
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8. Passive, continuous monitoring of carbon dioxide geostorage using muon tomography
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Gluyas, Jon, Thompson, Lee, Allen, Dave, Benton, Charlotte, Chadwick, Paula, Clark, Sam, Klinger, Joel, Kudryavtsev, Vitaly, Lincoln, Darren, Maunder, Ben, Mitchell, Cathryn, Nolan, Sam, Paling, Sean, Spooner, Neil, Staykov, Lazar, Telfer, Sam, Woodward, David, and Coleman, Max
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- 2019
9. Improving Clinical Decisions Via Remote Blood Sampling Opportunities for this patient-centric approach in sample collection
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Wickremsinhe, Enaksha, Anderson, Melanie, and Spooner, Neil
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Technology application ,Physicians -- Technology application ,Blood tests -- Technology application ,Patient compliance -- Technology application ,COVID-19 -- Technology application ,Blood -- Medical examination - Abstract
There is increased interest in the provision of healthcare in a manner that is more convenient to the patient. The COVID-19 pandemic has further shifted this trend, driven by the [...]
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- 2022
10. The effect of Tributyltin (TBT) on the steroid biochemistry of Nucella lapillus, and its possible relationship to the development of imposex
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Spooner, Neil
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572 ,Biochemistry - Published
- 1991
11. Technical Design Report - TDR CYGNO-04/INITIUM
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Mazzitelli, Giovanni, Baracchini, Elisabetta, Capoccia, Cesidio, Leonzi, Laura, Pinci, Davide, Rosatelli, Filippo, Tomassini, Sandro, Amaro, Fernando Domingues, Antonietti, Rita, Benussi, Luigi, Bianco, Stefano, Caponero, Michele, Cardoso, Danilo Santos, Cavoto, Gianluca, Cortez, André, Costa, Igor Abritta, Da Cruz Roque, Rita Joanna, Dane, Emiliano, Dho, Giorgio, Di Giambattista, Flaminia, Di Marco, Emanuele, Di Cortona, Giovanni Grilli, D'Imperio, Giulia, Iacoangeli, Francesco, Júnior, Herman Pessoa Lima, Kemp, Ernesto, Lopes, Guilherme Sebastiao Pinheiro, Da Silva Lopes Júnior, Amaro, Maccarrone, Giovanni, Mano, Rui Daniel Passos, Gregorio, Robert Renz Marcelo, Marques, David José Gaspar, McLean, Alasdair Gregor, Messina, Andrea, Monteiro, Cristina Maria Bernardes, Nobrega, Rafael Antunes, Pains, Igor Fonseca, Paoletti, Emiliano, Passamonti, Luciano, Petrucci, Fabrizio, Piacentini, Stefano, Piccolo, Davide, Pierluigi, Daniele, Prajapati, Atul, Renga, Francesco, Russo, Alessandro, Santos, Joaquim Marques Ferreira Dos, Saviano, Giovanna, Spooner, Neil John Curwen, Tesauro, Roberto, and Torelli, Samuele
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cygno ,solar neutrino ,cygnus ,gas electron multiplier (GEM) ,optical read out ,dark matter - Abstract
The aim of this Technical Design Report is to illustrate the technological choices foreseen to be implemented in the construction of the CYGNO-04 demonstrator, motivate them against the experiment physics goals of CYGNO-30 and demonstrate the financial sustainability of the project. CYGNO-04 represents PHASE 1 of the long term CYGNO roadmap, towards the development of large high precision tracking gaseous Time Projection Chamber (TPC) for directional Dark Matter searches and solar neutrino spectroscopy. The CYGNO project1 peculiarities reside in the optical readout of the light produced during the amplification of the primary ionization electrons in a stack of triple Gas Electron Multipliers (GEMs), thanks to the nice scintillation properties of the chosen He:CF4 gas mixture. To this aim, CYGNO is exploiting the fast progress in commercial scientific Active Pixel Sensors (APS) development for highly performing sCMOS cameras, whose high granularity and sensitivity allow to significantly boost tracking, improve particle identification and lower the energy threshold. The X-Y track project obtained from the reconstruction of the sCMOS images is combined with a PMT measurement to obtain a full 3D track reconstruction. In addition, several synergic R&Ds based on the CYGNO experimental approach are under development in the CYGNO collaboration (see Sec 2) to further enhance the light yield by means of electro luminescence after the amplification stage, to improve the tracking performances by exploiting negative ion drift operation within the INITIUM ERC Consolidator Grant, and to boost the sensitivity to O(GeV) Dark Matter masses by employing hydrogen rich target towards the development of PHASE 2 (see Sec. 1.2). While still under optimization and subject to possible significant improvements, the CYGNO experimental approach performances and capabilities demonstrated so far with prototypes allow to foresee the development of an O(30) m3 experiment by 2026 for a cost of O(10) MEUROs. A CYGNO-30 experiment would be able to give a significant contribution to the search and study of Dark Matter with masses below 10 GeV/c2 for both SI and SD coupling. In case of a Dark Matter observation claim by other experiments, the information provided by a directional detector such as CYGNO would be fundamental to positively confirm the galactic origin of the allegedly detected Dark Matter signal. CYGNO-30 could furthermore provide the first directional measurement of solar neutrinos from the pp chain, possibly extending to lower energies the Borexino measurement2. In order to reach this goal, the CYGNO project is proceeding through a staged approach. The PHASE 0 50 L detector (LIME, recently installed underground LNGS) will validate the full performances of the optical readout via APS commercial cameras and PMTs and the Montecarlo simulation of the expected backgrounds. The full CYGNO-04 demonstrator will be realized with all the technological and material choices foreseen for CYGNO-30, to demonstrate the scalability of the experimental approach and the potentialities of the large PHASE 2 detector to reach the expected physics goals. The first PHASE 1 design anticipated a 1 m3 active volume detector with two back-to-back TPCs with a central cathode and 500 mm drift length. Each 1 m2 readout area would have been composed by 9 + 9 readout modules having the LIME PHASE 0 dimensions and layout. Time (end of INITIUM project by March 2025) and current space availability at underground LNGS (only Hall F) forced the rescaling of the PHASE 1 active volume and design to a 0.4 m3, hence CYGNO-04. CYGNO-04 will keep the back-to-back double TPC layout with 500 mm drift length each, but with an 800 x 500 mm2 readout area covered by a 2 + 2 modules based on LIME design. The reduction of the detector volume has no impact on the technological objectives of PHASE 1, since the modular design with central cathode, detector materials and shieldings and auxiliary systems are independent of the total volume. The physics reach (which is a byproduct of PHASE 1 and NOT an explicit goal) will be only very partially reduced (less than a factor 2 overall) since a smaller detector volume implies also a reduced background from internal materials radioactivity. In addition, the cost reduction of CYGNO-04 of about 1⁄3 with respect to CYGNO-1 illustrated in the CDR effectively makes the overall project more financially sustainable (see CBS in the last section). In summary this document will explain: the physical motivation of the CYGNO project and the technical motivations of the downscale of the PHASE 1 to CYGNO-04, 400 liters of active volume, with respect to the demonstrator presented in the CDR; the results of R&D and the Montecarlo expectations for PHASE 0; the technical choices, procedures and the executive drawings of CYGNO-04 in the Hall F of the LNGS; safety evaluations and the interference/request to the LNGS services; Project management, WBS/WBC, WP, GANTT, ecc
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- 2023
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12. Overcoming the barriers to the uptake of nonclinical microsampling in regulatory safety studies
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Chapman, Kathryn, Chivers, Simon, Gliddon, Dan, Mitchell, David, Robinson, Sally, Sangster, Tim, Sparrow, Susan, Spooner, Neil, and Wilson, Amanda
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- 2014
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13. Quantitative bioanalysis of paracetamol in rats using volumetric absorptive microsampling (VAMS)
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Denniff, Philip, Parry, Simon, Dopson, Wesley, and Spooner, Neil
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- 2015
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14. A device for dried blood microsampling in quantitative bioanalysis: overcoming the issues associated blood hematocrit
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Spooner, Neil, Denniff, Philip, Michielsen, Luc, De Vries, Ronald, Ji, Qin C, Arnold, Mark E, Woods, Karen, Woolf, Eric J, Xu, Yang, Boutet, Valérie, Zane, Patricia, Kushon, Stuart, and Rudge, James B
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- 2015
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15. Quantitative Analysis of Therapeutic Drugs in Dried Blood Spot Samples by Paper Spray Mass Spectrometry: An Avenue to Therapeutic Drug Monitoring
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Manicke, Nicholas Edward, Abu-Rabie, Paul, Spooner, Neil, Ouyang, Zheng, and Cooks, R. Graham
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- 2011
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16. Application of dried blood spots combined with HPLC-MS/MS for the quantification of acetaminophen in toxicokinetic studies
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Barfield, Matt, Spooner, Neil, Lad, Rakesh, Parry, Simon, and Fowles, Susan
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- 2008
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17. 2014 White Paper on recent issues in bioanalysis: a full immersion in bioanalysis (Part 1 – small molecules by LCMS)
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Fluhler, Eric, Hayes, Roger, Garofolo, Fabio, Dumont, Isabelle, Blaye, Olivier Le, Arnold, Mark, Bansal, Surendra, Verhaeghe, Tom, Wilson, Amanda, Stevenson, Lauren, Myler, Heather, Bauer, Ronald, Bergeron, Annik, Bustard, Mark, Cai, Xiao-Yan, Carbone, Mary, Cojocaru, Laura, Desai-Krieger, Daksha, Duggan, Jeff, Haidar, Sam, Ho, Stacy, Ingelse, Benno, Katori, Noriko, Lévesque, Ann, Lowes, Steve, Ma, Mark, Mettke, Katalina, Michon, Josée, Musuku, Adrien, Olah, Timothy, Patel, Shefali, Rose, Mark, Schultz, Gary, Smeraglia, John, Spooner, Neil, Stouffer, Bruce, Vazvaei, Faye, Wakelin-Smith, Jason, Wang, Jian, Welink, Jan, Whale, Emma, Woolf, Eric, Xue, Li, and Yang, Tong-Yuan
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- 2014
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18. Reducing pre-clinical blood volumes for toxicokinetics: toxicologists, pathologists and bioanalysts unite
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Chapman, Kathryn, Burnett, Josephine, Corvaro, Marco, Mitchell, David, Robinson, Sally, Sangster, Timothy, Sparrow, Susan, Spooner, Neil, and Wilson, Amanda
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- 2014
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19. EBF: reflection on bioanalytical assay requirements used to support liquid microsampling
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White, Stephen, Hawthorne, Glen, Dillen, Lieve, Spooner, Neil, Woods, Karen, Sangster, Timothy, Cobb, Zoe, and Timmerman, Philip
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- 2014
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20. European Bioanalysis Forum continued plans to support liquid microsampling
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Timmerman, Philip, White, Steve, Cobb, Zoe, Woods, Karen, de Vries, Ronald, Spooner, Neil, Sangster, Timothy, Dillen, Lieve, and Hawthorne, Glen
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- 2014
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21. Integrating internal and external bioanalytical support to deliver a diversified pharmaceutical portfolio
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Summerfield, Scott G, Evans, Christopher, Spooner, Neil, Dunn, John A, Szapacs, Matthew E, and Yang, Eric
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- 2014
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22. Direct quantitative bioanalysis of drugs in dried blood spot samples using a thin-layer chromatography mass spectrometer interface
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Abu-Rabie, Paul and Spooner, Neil
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Mass spectrometry -- Methods ,Thin layer chromatography -- Methods ,Blood -- Analysis and chemistry ,Blood -- Methods ,Chemistry - Abstract
The CAMAG thin-layer chromatography mass spectrometer (TLC--MS) interface has been assessed as a tool for the direct quantitative bioanalysis of drugs from dried blood spot (DBS) samples, using an MS detector, with or without high-performance liquid chromatography (HPLC) separation. The approach gave acceptable sensitivity, linearity, accuracy, and precision data for bioanalytical validations with and without the inclusion of HPLC separation. In addition, the direct elution technique was shown to increase assay sensitivity for a range of analytes representing a wide 'chemical space' for pharmaceutical-type molecules over that obtained by conventional manual extraction of samples (punching of DBS and elution with solvent prior to HPLC--MS analysis). Investigations were performed to optimize extraction time, minimize sample-to-sample carry-over, and compare chromatographic performance. On the basis of this preliminary assessment, it has been demonstrated that the TLC-MS interface has the potential to be an effective tool for the direct analysis of drugs in DBS samples at physiologically relevant concentrations, an approach that could provide significant time and cost savings and greatly simplify bioanalytical procedures compared to current manual practices. Further, the increased sensitivity compared to that of manual extraction may enable the analysis of analytes not currently amenable to DBS sampling due to limitations in assay sensitivity. 10.1021/ac901985e
- Published
- 2009
23. Dried blood spots as a sample collection technique for the determination of pharmacokinetics in clinical studies: considerations for the validation of a quantitative bioanalytical method
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Spooner, Neil, Lad, Rakesh, and Barfield, Matt
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Blood -- Properties ,Clinical chemistry -- Research ,Pharmacokinetics -- Research ,High performance liquid chromatography -- Methods ,Mass spectrometry -- Methods ,Chemistry - Abstract
A novel approach has been developed for the quantitative determination of circulating drug concentrations in clinical studies using dried blood spots (DBS) on paper, rather than conventional plasma samples. A quantitative bioanalytical HPLC-MS/MS assay requiring small blood volumes (15/[micro]L) has been validated using acetaminophen as a tool compound (range 25 to 5000 ng/mL human blood). The assay employed simple solvent extraction of a punch taken from the DBS sample, followed by reversed phase HPLC separation, combined with selected reaction monitoring mass spectrometric detection. In addition to performing routine experiments to establish the validity of the assay to internationally accepted criteria (precision, accuracy, linearity, sensitivity, selectivity), a number of experiments were performed to specifically demonstrate the quality of the quantitative data generated using this novel sample format, namely, stability of the analyte and metabolites in whole human blood and in DBS samples; effect of the volume of blood spotted, the device used to spot the blood, or the temperature of blood spotted. The validated DBS approach was successfully applied to a clinical study (single oral dose of 500 mg or 1 g acetaminophen).
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- 2009
24. Inflammation and cardiovascular status impact midazolam pharmacokinetics in critically ill children: An observational, prospective, controlled study.
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Neupane, Bikalpa, Pandya, Hitesh, Pandya, Tej, Austin, Rupert, Spooner, Neil, Rudge, James, and Mulla, Hussain
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CRITICALLY ill children ,MIDAZOLAM ,BOLUS drug administration ,PHARMACOKINETICS ,C-reactive protein ,CRITICALLY ill - Abstract
Altered physiology caused by critical illness may change midazolam pharmacokinetics and thereby result in adverse reactions and outcomes in this vulnerable patient population. This study set out to determine which critical illness-related factors impact midazolam pharmacokinetics in children using population modeling. This was an observational, prospective, controlled study of children receiving IV midazolam as part of routine care. Children recruited into the study were either critically-ill receiving continuous infusions of midazolam or otherwise well, admitted for elective daycase surgery (control) who received a single IV bolus dose of midazolam. The primary outcome was to determine the population pharmacokinetics and identify covariates that influence midazolam disposition during critical illness. Thirty-five patients were recruited into the critically ill arm of the study, and 54 children into the control arm. Blood samples for assessing midazolam and 1-OH-midazolam concentrations were collected opportunistically (critically ill arm) and in pre-set time windows (control arm). Pharmacokinetic modeling demonstrated a significant change in midazolam clearance with acute inflammation (measured using C-Reactive Protein), cardio-vascular status, and weight. Simulations predict that elevated C-Reactive Protein and compromised cardiovascular function in critically ill children result in midazolam concentrations up to 10-fold higher than in healthy children. The extremely high concentrations of midazolam observed in some critically-ill children indicate that the current therapeutic dosing regimen for midazolam can lead to over-dosing. Clinicians should be aware of this risk and intensify monitoring for oversedation in such patients. [ABSTRACT FROM AUTHOR]
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- 2022
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25. Multiplexed extraction and quantitative analysis of pharmaceuticals from DBS samples using digital microfluidics
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Lafrenière, Nelson M, Shih, Steve CC, Abu-Rabie, Paul, Jebrail, Mais J, Spooner, Neil, and Wheeler, Aaron R
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- 2014
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26. Preliminary investigation into the use of a real-time PCR method for the quantification of an oligonucleotide in human plasma and the development of novel acceptance criteria
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Hughes, Stephen, Byrne, Alexander, Barfield, Matthew, Spooner, Neil, and Summerfield, Scott
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- 2014
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27. Assessment of the within- and between-lot variability of Whatman™ FTA® DMPK and 903® DBS papers and their suitability for the quantitative bioanalysis of small molecules
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Luckwell, Jacquelynn, Denniff, Philip, Capper, Stephen, Michael, Paul, Spooner, Neil, Mallender, Philip, Johnson, Barry, Clegg, Sarah, Green, Mark, Ahmad, Sheelan, and Woodford, Lynsey
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- 2013
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28. In-depth study of homogeneity in DBS using two different techniques: results from the EBF DBS-microsampling consortium
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Cobb, Zoe, de Vries, Ronald, Spooner, Neil, Williams, Stephen, Staelens, Ludovicus, Doig, Mira, Broadhurst, Rebecca, Barfield, Matthew, van de Merbel, Nico, Schmid, Bernhard, Siethoff, Christoph, Ortiz, Jordi, Verheij, Elwin, van Baar, Ben, White, Steve, and Timmerman, Philip
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- 2013
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29. Effect of ambient humidity on the rate at which blood spots dry and the size of the spot produced
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Denniff, Philip, Woodford, Lynsey, and Spooner, Neil
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- 2013
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30. A novel approach to capillary plasma microsampling for quantitative bioanalysis
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Bowen, Chester L, Licea-Perez, Hermes, Karlinsey, Molly Z, Jurusik, Kristen, Pierre, Esaie, Siple, Joseph, Kenney, Jim, Stokes, Alan, Spooner, Neil, and Evans, Christopher A
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- 2013
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31. A dried blood spot update: still an important bioanalytical technique?
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Spooner, Neil
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- 2013
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32. Dried blood spots and sparse sampling: a practical approach to estimating pharmacokinetic parameters of caffeine in preterm infants
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Patel, Parul, Mulla, Hussain, Kairamkonda, Venkatesh, Spooner, Neil, Gade, Sonya, Della Pasqua, Oscar, Field, David J., and Pandya, Hitesh C.
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- 2013
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33. Differential Muon Tomography to Continuously Monitor Changes in the Composition of Subsurface Fluids
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Coleman, Max, Kudryavtsev, Vitaly A, Spooner, Neil J, Fung, Cora, and Gluyas, John
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Man/System Technology And Life Support - Abstract
Muon tomography has been used to seek hidden chambers in Egyptian pyramids and image subsurface features in volcanoes. It seemed likely that it could be used to image injected, supercritical carbon dioxide as it is emplaced in porous geological structures being used for carbon sequestration, and also to check on subsequent leakage. It should work equally well in any other application where there are two fluids of different densities, such as water and oil, or carbon dioxide and heavy oil in oil reservoirs. Continuous monitoring of movement of oil and/or flood fluid during enhanced oil recovery activities for managing injection is important for economic reasons. Checking on leakage for geological carbon storage is essential both for safety and for economic purposes. Current technology (for example, repeat 3D seismic surveys) is expensive and episodic. Muons are generated by high- energy cosmic rays resulting from supernova explosions, and interact with gas molecules in the atmosphere. This innovation has produced a theoretical model of muon attenuation in the thickness of rock above and within a typical sandstone reservoir at a depth of between 1.00 and 1.25 km. Because this first simulation was focused on carbon sequestration, the innovators chose depths sufficient for the pressure there to ensure that the carbon dioxide would be supercritical. This innovation demonstrates for the first time the feasibility of using the natural cosmic-ray muon flux to generate continuous tomographic images of carbon dioxide in a storage site. The muon flux is attenuated to an extent dependent on, amongst other things, the density of the materials through which it passes. The density of supercritical carbon dioxide is only three quarters that of the brine in the reservoir that it displaces. The first realistic simulations indicate that changes as small as 0.4% in the storage site bulk density could be detected (equivalent to 7% of the porosity, in this specific case). The initial muon flux is effectively constant at the surface of the Earth. Sensitivity of the method would be decreased with increasing depth. However, sensitivity can be improved by emplacing a greater array of particle detectors at the base of the reservoir.
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- 2013
34. Dried matrix spot direct analysis: evaluating the robustness of a direct elution technique for use in quantitative bioanalysis
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Abu-Rabie, Paul and Spooner, Neil
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- 2011
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35. Dried blood spots, pharmacokinetic studies and better medicines for children
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Pandya, Hitesh C, Spooner, Neil, and Mulla, Hussain
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- 2011
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36. Rapid analysis of dried blood spot samples with sub-2-μm LC-MS/MS
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Mather, Joanne, Rainville, Paul D, Spooner, Neil, Evans, Christopher A, Smith, Norman W, and Plumb, Robert S
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- 2011
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37. Effect of storage conditions on the weight and appearance of dried blood spot samples on various cellulose-based substrates
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Denniff, Philip and Spooner, Neil
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- 2010
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38. Dried blood spot sampling for quantitative bioanalysis: time for a revolution?
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Spooner, Neil
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- 2010
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39. Use of DBS sample collection to determine circulating drug concentrations in clinical trials: practicalities and considerations
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Spooner, Neil, Ramakrishnan, Y, Barfield, M, Dewit, O, and Miller, S
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- 2010
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40. Study to assess the effect of age of control human and animal blood on its suitability for use in quantitative bioanalytical DBS methods
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Abu-Rabie, Paul and Spooner, Neil
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- 2010
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41. The effect of hematocrit on assay bias when using DBS samples for the quantitative bioanalysis of drugs
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Denniff, Philip and Spooner, Neil
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- 2010
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42. A glowing future for dried blood spot sampling
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Spooner, Neil
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- 2010
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43. New techniques in hard X-ray astronomy
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Spooner, Neil John Curwen
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530 - Published
- 1986
44. Deep Underground Neutrino Experiment (DUNE), Far Detector Technical Design Report, Volume I Introduction to DUNE
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Abi, Babak, Acciarri, Roberto, Acero, Mario, Adamov, Giorge, Adams, David, Adinolfi, Marco, Ahmad, Zubayer, Ahmed, Jhanzeb, Alion, Tyler, Alonso Monsalve, Saul, Alt, Christoph, Anderson, John, Andreopoulos, Costas, Andrews, Michael P, Andriamirado, Manoa, Andrianala, Fenompanirina, Andringa, Sofia, Ankowski, Artur, Anthony, Jack, Antoniu, Iliescu, Antonova, Maria, Antusch, Stefan, Aranda Fernandez, Alfredo, Ariga, Akitaka, Arnold, Lukas, Arroyave, Manuel, Asaadi, Jonathan, Aurisano, Adam, Aushev, Vladimir, Autiero, Dario, Azfar, Farrukh, Back, Ashley, Back, Henning, Back, John, Backhouse, Chris, Baesso, Paolo, Bagby, Linda, Bajou, Raphael, Balasubramanian, Supraja, Baldi, Pierre, Bambah, Bindu, Barao, Fernando, Barenboim, Gabriela, Barker, Gary J, Barkhouse, Wayne, Barnes, Christopher, Barr, Giles, Barranco Monarca, Juan, Barros, Nuno, Barrow, Joshua, Bashyal, Amit, Basque, Vincent, Bay, Fatih, Bazo Alba, J.L., Beacom, John, Bechetoille, Edouard, Behera, Biswaranjan, Bellantoni, Leo, Bellettini, Giorgio, Bellini, Vincenzo, Beltramello, Olga, Belver, D., Benekos, Nektarios, Bento Neves, Francisco, Berger, Joshua, Berkman, Sophie, Bernardini, Paolo, Berner, Roman, Berns, Hans-Gerd, Bertolucci, Sergio, Betancourt, Minerba, Bezawada, Y., Bhattacharjee, maharnab, Bhuyan, Bipul, Biagi, Simone, Bian, Jianming, Biassoni, Matteo, Biery, Kurt, Bilki, Burak, Bishai, Mary, Bitadze, Alexander, Blake, Andrew, Blanco Siffert, Beatriz, Blaszczyk, Flor de Maria, Blazey, Gerald C, Blucher, Edward, Boissevain, Jan, Bolognesi, Sara, Bolton, Timothy, Bonesini, Maurizio, Bongrand, Mathieu, Bonini, Filiberto, Booth, Alexander, Booth, Chris, Bordoni, Stefania, Borkum, Aran, Boschi, Tommaso, Bostan, Nilay, Bour, Petr, Boyd, Steve B, Boyden, Daniel, Bracinik, Juraj, Braga, Davide, Brailsford, Dominic, Brandt, Andrew, Bremer, Johan, Brew, Chris, Brianne, Eldwan, Brice, Stephen, Brizzolari, Claudia, Bromberg, Carl, Brooijmans, Gustaaf, Brooke, Jim, Bross, Alan, Brunetti, Giulia, Buchanan, Norman, Budd, Howard, Caiulo, Davide, Calafiura, Paolo, Calcutt, Jacob, Calin, Marius, Calvez, Steven, Calvo, Enrique, Camilleri, Leslie, Caminata, Alessio, Campanelli, Mario, Caratelli, David, Carini, Gabriella, Carlus, Bruno, Carniti, Paolo, Caro Terrazas, Ivan, Carranza, Hector, Castillo, Andrés, Castromonte, Cesar, Cattadori, Carla, Cavalier, Fabien, Cavanna, Flavio, Centro, Sandro, Cerati, Giuseppe, Cervelli, Alberto, Cervera Villanueva, Anselmo, Chalifour, Michel, Chang, C., Chardonnet, Etienne, Chatterjee, Animesh, Chattopadhyay, Subhasish, Chaves, Jorge, Chen, Hucheng, Chen, Mu-Chun, Chen, Yifan, Cherdack, Daniel, Chi, Cheng-Yi, Childress, Sam, Chiriacescu, Ana, Cho, Kihyeon, Choubey, Sandhya, Christensen, Anne, Christian, David, Christodoulou, Georgios, Church, Eric, Clarke, Peter, Coan, Thomas, Cocco, Alfredo, Coelho, Joao, Conley, Erin, Conrad, Janet M, Convery, Mark, Corwin, Luke, Cotte, Philippe, Cremaldi, Lucien, Cremonesi, Linda, Crespo-Anadón, Jose I, Cristaldo, Esteban, Cross, Ryan, Cuesta, Clara, Cui, Yanou, Cussans, David, Dabrowski, Mieczyslaw, Da Motta, Helio, Peres, L. Da Silva, David, Quentin, Davies, Gavin, Davini, Stefano, Dawson, Jaime, De, Kaushik, de Almeida, Rogerio, Debbins, Paul, De Bonis, Isabelle, Decowski, M Patrick, de Gouvea, Andre, de Holanda, Pedro, de Icaza Astiz, Iker, Deisting, Alexander, De Jong, Paul, Delbart, Alain, Delepine, David, Delgado, Maritza, Dell'Acqua, Andrea, De Lurgio, Patrick, Ewart, Kevin, Grant, Nick, Hernandez Morquecho, Miguel Angel, Hewes, Jeremy, Huang, Junting, Huang, Junying, Leigui de Oliveira, M A, Li, Shaorui, Li, Shirley W, Ramirez Delgado, Manuel Alejandro, Singh, Jaydip, Singh, Jyotsna, Smith, Adryanna, Smith, Andrew, Todd, Jacob, Torres de Mello Neto, Joao, DeMuth, David, Dennis, Steve, Densham, Chris, Gregor Recalde, Derlis, De Roeck, Albert, De Romeri, Valentina, Jan De Vries, Joris, Dharmapalan, Ranjan, Diaz, Felix, Diaz, Jorge S, Di Domizio, Sergio, Di Giulio, Letizia, Ding, Pengfei, Di Noto, Lea, Distefano, Carla, Diurba, Richard, Diwan, Milind, Djurcic, Zelimir, Dokania, Neha, Dolinski, Michelle J, Domine, Laura, Douglas, Daniel, Drielsma, Francois, Duchesneau, Dominique, Duffy, Kirsty, Dunne, Patrick, Durkin, Tim, Duyang, Hongyue, Dvornikov, Olexiy, Dwyer, Daniel A, Dyshkant, Alexandre S, Eads, Michael, Edmunds, Daniel, Eisch, Jonathan, Emery, Sandrine, Ereditato, Antonio, Escobar, Carlos O, Escudero Sanchez, Lorena, Evans, Justin, Ewart, E., Ezeribe, Anthony, Fahey, Kevin, Falcone, Andrea, Farnese, Christian, Farzan, Yasaman, Felix, Julian, Fernandez-Martinez, Enrique, Fernandez Menendez, Pablo, Ferraro, Federico, Fields, Laura, Filkins, A., Filthaut, Frank, Fitzpatrick, Rory, Flanagan, Will, Fleming, Bonnie, Flight, Robert, Fowler, Jack, Fox, Walt, Franc, Jiri, Francis, Kurt, Franco, Domenico, Freeman, John, Freestone, Julian, Fried, Jack, Friedland, Alex, Fuess, Stu, Furic, Ivan, Furmanski, Andrew, Gago, A., Gallagher, Hugh, Gallego-Ros, Ana, Gallice, Niccolo, Galymov, Vyacheslav, Gamberini, Enrico, Gamble, Trevor, Gandhi, Raj, Gandrajula, Reddy, Gao, Shanshan, Garcia-Gamez, Diego, García-Peris, Miguel, Gardiner, Steven, Gastler, Dan, Ge, Guanqun, Gelli, Bruno, Gendotti, Adamo, Gent, Stephen, Ghorbani-Moghaddam, Zahra, Gibin, Daniele, Gil-Botella, Ines, Girerd, Claude, Giri, Anjan Kumar, Gnani, D., Gogota, Olga, Gold, Michael, Gollapinni, Sowjanya, Gollwitzer, Keith, Gomes, Ricardo, Gomez Bermeo, Laura Vanessa, Gomez Fajardo, Luz, Gonnella, Francesco, Gonzalez-Cuevas, Juan Alberto, Goodman, Maury, Goodwin, Owen, Goswami, Srubabati, Gotti, Claudio, Goudzovski, Evgueni, Grace, Carl, Graham, Mathew, Gramellini, E., Gran, Rik, Granados, Everardo, Grant, Alan, Grant, Christopher, Gratieri, Diego, Green, Patrick, Green, Steven, Greenler, Leland, Greenwood, M., Greer, Joel, Griffith, Clark, Groh, Micah, Grudzinski, James, Grzelak, Katarzyna, Gu, Wenqiang, Guarino, Victor, Guenette, Roxanne, Guglielmi, Alberto, Guo, Bing, Guthikonda, K K, Gutierrez, Rafael, Guzowski, Pawel, Guzzo, Marcelo, Gwon, Sunwoo, Habig, Alec, Hackenburg, A., Hadavand, Haleh, Haenni, Roger, Hahn, Alan, Haigh, Jennifer, Haiston, James, Hamernik, Thomas, Hamilton, Philip, Han, Jiyeon, Harder, Kristian, Harris, Debbie, Hartnell, Jeffrey, Hasegawa, Takyua, Hatcher, Robert, Hazen, Eric, Heavey, Anne, Heeger, Karsten, Hennessy, Karol, Henry, Sarah, Herner, Kenneth, Hertel, Lars, Hewes, V., Higuera Pichardo, Aaron, Hill, Tony, Hillier, Stephen, Himmel, Alexander, Hoff, James, Hohl, Christian, Holin, Anna, Hoppe, Eric, Horton-Smith, Glenn, Hostert, Matheus, Hourlier, Adrien, Howard, Bruce, Howell, Ryan, Hugon, Justin, Iles, Gregory, Illingworth, Robert, Ioannisian, Ara, Itay, Ran, Izmaylov, Alexander, James, Eric, Jargowsky, B., Jediny, Filip, Jesús-Valls, César, Ji, Xiangpan, Jiang, L., Jiménez, Sergio, Jipa, Alexandru, Johnson, Connor, Johnson, Randy, Jones, Benjamin, Jones, Sebastian, Jung, Chang Kee, Junk, Thomas, Jwa, Yeon-jae, Kabirnezhad, Monireh, Kaboth, Asher, Kadenko, I, Kamiya, Felipe, Karagiorgi, Georgia, Karcher, A., Karolak, Mark, Karyotakis, Yannis, Kasai, Seiji, Kasetti, Siva, Kashur, Lane, Kazaryan, Narine, Kearns, Edward, Keener, Paul, Kelly, Kevin, Kemp, Ernesto, Ketchum, Wes, Kettell, Steve H, Khabibullin, Marat, Khotjantsev, Alexei, Khvedelidze, Arsen, Kim, D., King, Bonnie, Kirby, Brian, Kirby, Mike, Klein, Joshua, Koehler, Kevin, Koerner, Lisa, Kohn, Sam, Koller, Patrick, Kordosky, Mike, Kosc, Thomas, Kose, Umut, Kostelecky, V Alan, Kothekar, Kunal, Krennrich, Frank, Kreslo, Igor, Kudenko, Yury, Kudryavtsev, Vitaly A, Kulagin, Sergey, Kumar, Jason, KUMAR, Rajeev, Kuruppu, Chatura, Kus, Vaclav, Kutter, Thomas, Lambert, A., Lande, Kenneth, Lane, Charles, Lang, Karol, Langford, Thomas, Lasorak, Pierre, Last, David, Lastoria, Chiara, Laundrie, Andy, Lawrence, A., Lazanu, Ionel, LaZur, Ryan, Le, Trung, Learned, John, LeBrun, Patrice, Lehmann Miotto, Giovanna, Lehnert, Ralf, Leitner, M., Leyton, Michael, Li, Lingge, Li, Teng, Li, Yichen, Liao, Heng-Ye, Lin, Cheng-Ju Stephen, Lin, Shih-Kai, Lister, Adam, Littlejohn, Bryce, Liu, J., Lockwitz, Sarah, Loew, Timothy, Lokajicek, Milos, Lomidze, Irakli, Long, Ken, Loo, Kai, Lorca, David, Lord, Tom, LoSecco, John M, Louis, William, Luk, Kam-Biu, Luo, Xiao, Lurkin, Nicolas, Lux, Thorsten, Luzio, Vitor Prestes, MacFarlane, David, Machado, Ana Amelia, Machado, Pedro, Macias, Christopher Thomas, Macier, Jolie R, Maddalena, Antonello, Madigan, Peter, Magill, Steve, Mahn, Kendall, Maio, Amélia, Maloney, James, Mandrioli, Gianni, Maneira, José, Manenti, Laura, Manly, Steve, Mann, Anthony, Manolopoulos, Konstantinos, Manrique Plata, Maria, Marchionni, Alberto, Marciano, William, Marfatia, Danny, Mariani, Camillo, Maricic, Jelena, Marinho, Franciole, Marino, Alysia, Marshak, Marvin, Marshall, Chris, Marshall, John, Marteau, Jacques, Martin-Albo, Justo, Martinez, Norman, Martinez Caicedo, David, Martynenko, Sergey, Mason, Katie, Mastbaum, Andrew, Masud, Mehedi, Matsuno, Shigenobu, Matthews, James, Mauger, Christopher, Mauri, Nicoletta, Mavrokoridis, Konstantinos, Mazza, Roberto, Mazzacane, Anna, Mazzucato, Edoardo, McCluskey, Elaine, McConkey, Nicola, McFarland, Kevin, McGrew, Clark, McNab, Andrew, Mefodiev, Alexander, Mehta, Poonam, Melas, Pantelis, Mellinato, Michele, Mena, Olga, Menary, Scott, Mendes Santos, Lucas, Mendez, Hector, Menegolli, A, Meng, Guang, Messier, Mark, Metcalf, William, Mewes, Matthew, Meyer, Holger, Miao, Ting, Michna, Gregory, Miedema, Thijs, Migenda, Jost, Milincic, Radovan, Miller, William, Mills, Joshua, Milne, Cody, Mineev, Oleg, Miranda, Omar, Miryala, Sandeep, Mishra, C Shekhar, Mishra, Sanjib R, Mislivec, Aaron, Mladenov, Dimitar, Mocioiu, Irina, Moffat, Kristian, Moggi, Niccolo, Mohanta, Rukmani, Mohayai, Tanaz, Mokhov, Nikolai, Molina, Jorge, Molina Bueno, Laura, Montanari, Alessandro, Montanari, Claudio, Montanari, David, Montano Zetina, Luis, Moon, Jarrett, Mooney, Michael, Moreno, Deywis, Morgan, Ben, Morris, Casandra, Mossey, Chris, Motuk, Erdem, Moura, Célio, Mousseau, Joel, Mu, Wei, Mualem, Leon, Mueller, Justin, Muether, Mathew, Mufson, Stuart, Muheim, Franz, Muir, Alan, Mulhearn, Mike, Muramatsu, Hajime, Murphy, Sebastien, Musser, Jim, Nachtman, Jane, Nagu, S., Nalbandyan, Mikayel, Nandakumar, Raja, Naples, Donna, Narita, Shinya, Navas-Nicolas, D., Nayak, Nitish, Nebot-Guinot, Miquel, Necib, Lina, Negishi, Kentaro, Nelson, Jeff, Nesbit, Jake, Nessi, Marzio, Newbold, David, Newcomer, Mitch, Newhart, Duane, Nichol, Ryan, Niner, Evan, Nishimura, Kurtis, Norman, Andrew, Northrop, Rich, Novella, Pau, Nowak, Jaroslaw, Oberling, Michael, Olivares Del Campo, Andres, Olivier, Andrew, Onel, Yasar, Onishchuk, Yuriy, Ott, Jordan, Pagani, Luca, Pakvasa, Sandip, Palamara, Ornella, Palestini, Sandro, Paley, Jonathan, Pallavicini, Marco, Palomares, Carmen, Pantic, Emilija, Paolone, Vittorio, Papadimitriou, Vaia, Papaleo, Riccardo, Papanestis, Antonis, Paramesvaran, Sudarshan, Parke, Stephen, Parsa, Zohreh, Parvu, Mihaela, Pascoli, Silvia, Pasqualini, Laura, Pasternak, Jaroslaw, Pater, Joleen, Patrick, Cheryl, Patrizii, Laura, Patterson, Ryan, Patton, Simon John, Patzak, Thomas, Paudel, Ajib, Paulos, Bob, Paulucci, Laura, Pavlovic, Zarko, Pawloski, Greg, Payne, David, Pec, Viktor, Peeters, Simon, Penichot, Yves, Pennacchio, Elisabetta, Penzo, Aldo, Peres, Orlando, Perry, James, Pershey, Daniel, Pessina, Gianluigi, Petrillo, Gianluca, Petta, Catia, Petti, Roberto, Piastra, Francesco, Pickering, Luke, Pietropaolo, Francesco, Pillow, James, Plunkett, Robert, Poling, Ronald, Pons, Xavier, Poonthottathil, Navaneeth, Pordes, Stephen, Potekhin, Maxim, Potenza, Renato, Potukuchi, B.V.K.S., Pozimski, Juergen, Pozzato, Michele, Prakash, Suprabh, Prakash, Tarun, Prince, Sebastien, Pugnere, Denis, Qi, K., Qian, Xin, Raaf, Jennifer L, Raboanary, R., Radeka, Veljko, Rademacker, Jonas, Radics, Balint, Rafique, Aleena, Raguzin, Eric, Rai, Mousam, Rajaoalisoa, Miriama, Rakhno, Igor, Rakotondramanana, H.T., Rakotondravohitra, Laza, Ramachers, Yorck A, Rameika, Regina, Ramson, Bryan, Rappoldi, A, Raselli, GL, Ratoff, Peter, Ravat, Sylvain, Razafinime, H., Real, Jean-Sebastien, Rebel, Brian, Redondo, David, Reggiani-Guzzo, Marina, Rehak, Tyler, Reichenbacher, Juergen, Reitzner, S, Renshaw, Andrew, Rescia, Sergio, Resnati, Filippo, Reynolds, Aidan, Riccobene, Giorgio, Rice, Logan, Rielage, Keith, Rigaut, Yann-Axel, Rivera, David, Rochester, Leon, Roda, Marco, Rodrigues, Philip, Rodriguez Alonso, Manual Jesus, Rodriguez Rondon, Jairo, Roeth, Alison J, Rogers, Hannah, Rosauro-Alcaraz, Salvador, Rossella, M, Rout, Jogesh, Roy, Samiran, Rubbia, Andre, Rubbia, Carlo, Russell, Brooke, Russell, James, Ruterbories, Daniel, Saakyan, Ruben, Sacerdoti, Sabrina, Safford, Twymun, Sahu, Narendra, Sala, Paola, Samios, Nicholas, Sanchez, Mayly, Sanders, David, Sankey, David, Santana, Samuel, Santos-Maldonado, Marvin, Saoulidou, Niki, Sapienza, Piera, Sarasty, Carlos, Sarcevic, Ina, Savage, Geoffrey, Savinov, Vladimir, Scaramelli, Alberto, Scarff, Andrew, Scarpelli, Andrea, Schaffer, Tom, 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Vallecorsa, Sofia, Van Berg, Rick, Van de Water, Richard, Vanegas Forero, David, Varanini, Filippo, Vargas, Danaisis, Varner, Gary, Vasel, Justin, Vasseur, Georges, Vaziri, Kamran, Ventura, Sandro, Verdugo, Antonio, Vergani, Stefano, Vermeulen, Milo, Verzocchi, Marco, Vieira de Souza, Henrique, Vignoli, Chiara, Vilela, Cristovao, Viren, Brett, Vrba, Tomas, Wachala, Tomasz, Waldron, Abigail, Wallbank, Michael, Wang, Hanguo, Wang, Jingbo, Wang, Yi, Wang, Yue, Warburton, Karl, Warner, David, Wascko, Morgan, Waters, David, Watson, Alan, Weatherly, Pierce, Weber, Alfons, Weber, Michele, Wei, Hanyu, Weinstein, Amanda, Wenman, Dan, Wetstein, Matthew, Yang, Shaokai, Zeller, Geralyn (Sam), While, M.R., White, Andy, Whitehead, Leigh, Whittington, Denver, Wilking, Michael, Wilkinson, Callum, Williams, Zachary, Wilson, Fergus, Wilson, Robert, Wolcott, Jeremy, Wongjirad, Taritree, Wood, Kevin, Wood, Lynn, Worcester, Elizabeth, Worcester, Matthew, Wret, Clarence, Wu, Wanwei, Xiao, Y., Yang, Guang, Yang, Tingjun, Yershov, Nikolai, Yonehara, Katsuya, Young, Tim, Yu, Bo, Yu, Jae, Zalesak, Jaroslav, Zambelli, Laura, Zamorano, Bruno, Zani, Andrea, Zazueta, Luis, Zeller, G.P., Zennamo, Joseph, Zeug, Kyle, Zhang, Chao, Zhao, Manhong, Zhivun, Elena, Zhu, Guanying, Zimmerman, Eric, Zito, Marco, Zucchelli, Stefano, Zuklin, Josef, Zutshi, Vishnu, Zwaska, Robert, Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), DUNE, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), and Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
detector: technology ,Physics - Instrumentation and Detectors ,hep-ex ,Physics::Instrumentation and Detectors ,far detector ,FOS: Physical sciences ,Instrumentation and Detectors (physics.ins-det) ,time projection chamber: liquid argon ,High Energy Physics - Experiment ,High Energy Physics - Experiment (hep-ex) ,neutrino: deep underground detector ,near detector ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,High Energy Physics::Experiment ,data management ,[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det] ,Detectors and Experimental Techniques ,physics.ins-det ,Particle Physics - Experiment ,activity report ,detector: design - Abstract
The preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decay -- these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our universe, its current state, and its eventual fate. The Deep Underground Neutrino Experiment (DUNE) is an international world-class experiment dedicated to addressing these questions as it searches for leptonic charge-parity symmetry violation, stands ready to capture supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector technical design report (TDR) describes the DUNE physics program and the technical designs of the single- and dual-phase DUNE liquid argon TPC far detector modules. This TDR is intended to justify the technical choices for the far detector that flow down from the high-level physics goals through requirements at all levels of the Project. Volume I contains an executive summary that introduces the DUNE science program, the far detector and the strategy for its modular designs, and the organization and management of the Project. The remainder of Volume I provides more detail on the science program that drives the choice of detector technologies and on the technologies themselves. It also introduces the designs for the DUNE near detector and the DUNE computing model, for which DUNE is planning design reports. Volume II of this TDR describes DUNE's physics program in detail. Volume III describes the technical coordination required for the far detector design, construction, installation, and integration, and its organizational structure. Volume IV describes the single-phase far detector technology. A planned Volume V will describe the dual-phase technology., Comment: Minor corrections made for JINST submission; 244 pages, 114 figures
- Published
- 2020
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45. Deep Underground Neutrino Experiment (DUNE), Far Detector Technical Design Report, Volume III: DUNE Far Detector Technical Coordination
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Abi, Babak, Acciarri, Roberto, Acero, Mario, Adamov, Giorge, Adams, David, Adinolfi, Marco, Ahmad, Zubayer, Ahmed, Jhanzeb, Alion, Tyler, Alonso Monsalve, Saul, Alt, Christoph, Anderson, John, Andreopoulos, Costas, Andrews, Michael P, Andriamirado, Manoa, Andrianala, Fenompanirina, Andringa, Sofia, Ankowski, Artur, Anthony, Jack, Antoniu, Iliescu, Antonova, Maria, Antusch, Stefan, Aranda Fernandez, Alfredo, Ariga, Akitaka, Arnold, Lukas, Arroyave, Manuel, Asaadi, Jonathan, Aurisano, Adam, Aushev, Vladimir, Autiero, Dario, Azfar, Farrukh, Back, Ashley, Back, Henning, Back, John, Backhouse, Chris, Baesso, Paolo, Bagby, Linda, Bajou, Raphael, Balasubramanian, Supraja, Baldi, Pierre, Bambah, Bindu, Barao, Fernando, Barenboim, Gabriela, Barker, Gary J, Barkhouse, Wayne, Barnes, Christopher, Barr, Giles, Barranco Monarca, Juan, Barros, Nuno, Barrow, Joshua, Bashyal, Amit, Basque, Vincent, Bay, Fatih, Bazo Alba, J.L., Beacom, John, Bechetoille, Edouard, Behera, Biswaranjan, Bellantoni, Leo, Bellettini, Giorgio, Bellini, Vincenzo, Beltramello, Olga, Belver, D., Benekos, Nektarios, Bento Neves, Francisco, Berger, Joshua, Berkman, Sophie, Bernardini, Paolo, Berner, Roman, Berns, Hans-Gerd, Bertolucci, Sergio, Betancourt, Minerba, Bezawada, Y., Bhattacharjee, maharnab, Bhuyan, Bipul, Biagi, Simone, Bian, Jianming, Biassoni, Matteo, Biery, Kurt, Bilki, Burak, Bishai, Mary, Bitadze, Alexander, Blake, Andrew, Blanco Siffert, Beatriz, Blaszczyk, Flor de Maria, Blazey, Gerald C, Blucher, Edward, Boissevain, Jan, Bolognesi, Sara, Bolton, Timothy, Bonesini, Maurizio, Bongrand, Mathieu, Bonini, Filiberto, Booth, Alexander, Booth, Chris, Bordoni, Stefania, Borkum, Aran, Boschi, Tommaso, Bostan, Nilay, Bour, Petr, Boyd, Steve B, Boyden, Daniel, Bracinik, Juraj, Braga, Davide, Brailsford, Dominic, Brandt, Andrew, Bremer, Johan, Brew, Chris, Brianne, Eldwan, Brice, Stephen, Brizzolari, Claudia, Bromberg, Carl, Brooijmans, Gustaaf, Brooke, Jim, Bross, Alan, Brunetti, Giulia, Buchanan, Norman, Budd, Howard, Caiulo, Davide, Calafiura, Paolo, Calcutt, Jacob, Calin, Marius, Calvez, Steven, Calvo, Enrique, Camilleri, Leslie, Caminata, Alessio, Campanelli, Mario, Caratelli, David, Carini, Gabriella, Carlus, Bruno, Carniti, Paolo, Caro Terrazas, Ivan, Carranza, Hector, Castillo, Andrés, Castromonte, Cesar, Cattadori, Carla, Cavalier, Fabien, Cavanna, Flavio, Centro, Sandro, Cerati, Giuseppe, Cervelli, Alberto, Cervera Villanueva, Anselmo, Chalifour, Michel, Chang, C., Chardonnet, Etienne, Chatterjee, Animesh, Chattopadhyay, Subhasish, Chaves, Jorge, Chen, Hucheng, Chen, Mu-Chun, Chen, Yifan, Cherdack, Daniel, Chi, Cheng-Yi, Childress, Sam, Chiriacescu, Ana, Cho, Kihyeon, Choubey, Sandhya, Christensen, Anne, Christian, David, Christodoulou, Georgios, Church, Eric, Clarke, Peter, Coan, Thomas, Cocco, Alfredo, Coelho, Joao, Conley, Erin, Conrad, Janet M, Convery, Mark, Corwin, Luke, Cotte, Philippe, Cremaldi, Lucien, Cremonesi, Linda, Crespo-Anadón, Jose I, Cristaldo, Esteban, Cross, Ryan, Cuesta, Clara, Cui, Yanou, Cussans, David, Dabrowski, Mieczyslaw, Da Motta, Helio, Peres, L. Da Silva, David, Quentin, Davies, Gavin, Davini, Stefano, Dawson, Jaime, De, Kaushik, de Almeida, Rogerio, Debbins, Paul, De Bonis, Isabelle, Decowski, M Patrick, de Gouvea, Andre, de Holanda, Pedro, de Icaza Astiz, Iker, Deisting, Alexander, De Jong, Paul, Delbart, Alain, Delepine, David, Delgado, Maritza, Dell'Acqua, Andrea, De Lurgio, Patrick, Ewart, Kevin, Grant, Nick, Hernandez Morquecho, Miguel Angel, Hewes, Jeremy, Huang, Junting, Huang, Junying, Leigui de Oliveira, M A, Li, Shaorui, Li, Shirley W, Ramirez Delgado, Manuel Alejandro, Singh, Jaydip, Singh, Jyotsna, Smith, Adryanna, Smith, Andrew, Todd, Jacob, Torres de Mello Neto, Joao, DeMuth, David, Dennis, Steve, Densham, Chris, Gregor Recalde, Derlis, De Roeck, Albert, De Romeri, Valentina, Jan De Vries, Joris, Dharmapalan, Ranjan, Diaz, Felix, Diaz, Jorge S, Di Domizio, Sergio, Di Giulio, Letizia, Ding, Pengfei, Di Noto, Lea, Distefano, Carla, Diurba, Richard, Diwan, Milind, Djurcic, Zelimir, Dokania, Neha, Dolinski, Michelle J, Domine, Laura, Douglas, Daniel, Drielsma, Francois, Duchesneau, Dominique, Duffy, Kirsty, Dunne, Patrick, Durkin, Tim, Duyang, Hongyue, Dvornikov, Olexiy, Dwyer, Daniel A, Dyshkant, Alexandre S, Eads, Michael, Edmunds, Daniel, Eisch, Jonathan, Emery, Sandrine, Ereditato, Antonio, Escobar, Carlos O, Escudero Sanchez, Lorena, Evans, Justin, Ewart, E., Ezeribe, Anthony, Fahey, Kevin, Falcone, Andrea, Farnese, Christian, Farzan, Yasaman, Felix, Julian, Fernandez-Martinez, Enrique, Fernandez Menendez, Pablo, Ferraro, Federico, Fields, Laura, Filkins, A., Filthaut, Frank, Fitzpatrick, Rory, Flanagan, Will, Fleming, Bonnie, Flight, Robert, Fowler, Jack, Fox, Walt, Franc, Jiri, Francis, Kurt, Franco, Domenico, Freeman, John, Freestone, Julian, Fried, Jack, Friedland, Alex, Fuess, Stu, Furic, Ivan, Furmanski, Andrew, Gago, A., Gallagher, Hugh, Gallego-Ros, Ana, Gallice, Niccolo, Galymov, Vyacheslav, Gamberini, Enrico, Gamble, Trevor, Gandhi, Raj, Gandrajula, Reddy, Gao, Shanshan, Garcia-Gamez, Diego, García-Peris, Miguel, Gardiner, Steven, Gastler, Dan, Ge, Guanqun, Gelli, Bruno, Gendotti, Adamo, Gent, Stephen, Ghorbani-Moghaddam, Zahra, Gibin, Daniele, Gil-Botella, Ines, Girerd, Claude, Giri, Anjan Kumar, Gnani, D., Gogota, Olga, Gold, Michael, Gollapinni, Sowjanya, Gollwitzer, Keith, Gomes, Ricardo, Gomez Bermeo, Laura Vanessa, Gomez Fajardo, Luz, Gonnella, Francesco, Gonzalez-Cuevas, Juan Alberto, Goodman, Maury, Goodwin, Owen, Goswami, Srubabati, Gotti, Claudio, Goudzovski, Evgueni, Grace, Carl, Graham, Mathew, Gramellini, E., Gran, Rik, Granados, Everardo, Grant, Alan, Grant, Christopher, Gratieri, Diego, Green, Patrick, Green, Steven, Greenler, Leland, Greenwood, M., Greer, Joel, Griffith, Clark, Groh, Micah, Grudzinski, James, Grzelak, Katarzyna, Gu, Wenqiang, Guarino, Victor, Guenette, Roxanne, Guglielmi, Alberto, Guo, Bing, Guthikonda, K K, Gutierrez, Rafael, Guzowski, Pawel, Guzzo, Marcelo, Gwon, Sunwoo, Habig, Alec, Hackenburg, A., Hadavand, Haleh, Haenni, Roger, Hahn, Alan, Haigh, Jennifer, Haiston, James, Hamernik, Thomas, Hamilton, Philip, Han, Jiyeon, Harder, Kristian, Harris, Debbie, Hartnell, Jeffrey, Hasegawa, Takyua, Hatcher, Robert, Hazen, Eric, Heavey, Anne, Heeger, Karsten, Hennessy, Karol, Henry, Sarah, Herner, Kenneth, Hertel, Lars, Hewes, V., Higuera Pichardo, Aaron, Hill, Tony, Hillier, Stephen, Himmel, Alexander, Hoff, James, Hohl, Christian, Holin, Anna, Hoppe, Eric, Horton-Smith, Glenn, Hostert, Matheus, Hourlier, Adrien, Howard, Bruce, Howell, Ryan, Hugon, Justin, Iles, Gregory, Illingworth, Robert, Ioannisian, Ara, Itay, Ran, Izmaylov, Alexander, James, Eric, Jargowsky, B., Jediny, Filip, Jesús-Valls, César, Ji, Xiangpan, Jiang, L., Jiménez, Sergio, Jipa, Alexandru, Johnson, Connor, Johnson, Randy, Jones, Benjamin, Jones, Sebastian, Jung, Chang Kee, Junk, Thomas, Jwa, Yeon-jae, Kabirnezhad, Monireh, Kaboth, Asher, Kadenko, I, Kamiya, Felipe, Karagiorgi, Georgia, Karcher, A., Karolak, Mark, Karyotakis, Yannis, Kasai, Seiji, Kasetti, Siva, Kashur, Lane, Kazaryan, Narine, Kearns, Edward, Keener, Paul, Kelly, Kevin, Kemp, Ernesto, Ketchum, Wes, Kettell, Steve H, Khabibullin, Marat, Khotjantsev, Alexei, Khvedelidze, Arsen, Kim, D., King, Bonnie, Kirby, Brian, Kirby, Mike, Klein, Joshua, Koehler, Kevin, Koerner, Lisa, Kohn, Sam, Koller, Patrick, Kordosky, Mike, Kosc, Thomas, Kose, Umut, Kostelecky, V Alan, Kothekar, Kunal, Krennrich, Frank, Kreslo, Igor, Kudenko, Yury, Kudryavtsev, Vitaly A, Kulagin, Sergey, Kumar, Jason, KUMAR, Rajeev, Kuruppu, Chatura, Kus, Vaclav, Kutter, Thomas, Lambert, A., Lande, Kenneth, Lane, Charles, Lang, Karol, Langford, Thomas, Lasorak, Pierre, Last, David, Lastoria, Chiara, Laundrie, Andy, Lawrence, A., Lazanu, Ionel, LaZur, Ryan, Le, Trung, Learned, John, LeBrun, Patrice, Lehmann Miotto, Giovanna, Lehnert, Ralf, Leitner, M., Leyton, Michael, Li, Lingge, Li, Teng, Li, Yichen, Liao, Heng-Ye, Lin, Cheng-Ju Stephen, Lin, Shih-Kai, Lister, Adam, Littlejohn, Bryce, Liu, J., Lockwitz, Sarah, Loew, Timothy, Lokajicek, Milos, Lomidze, Irakli, Long, Ken, Loo, Kai, Lorca, David, Lord, Tom, LoSecco, John M, Louis, William, Luk, Kam-Biu, Luo, Xiao, Lurkin, Nicolas, Lux, Thorsten, Luzio, Vitor Prestes, MacFarlane, David, Machado, Ana Amelia, Machado, Pedro, Macias, Christopher Thomas, Macier, Jolie R, Maddalena, Antonello, Madigan, Peter, Magill, Steve, Mahn, Kendall, Maio, Amélia, Maloney, James, Mandrioli, Gianni, Maneira, José, Manenti, Laura, Manly, Steve, Mann, Anthony, Manolopoulos, Konstantinos, Manrique Plata, Maria, Marchionni, Alberto, Marciano, William, Marfatia, Danny, Mariani, Camillo, Maricic, Jelena, Marinho, Franciole, Marino, Alysia, Marshak, Marvin, Marshall, Chris, Marshall, John, Marteau, Jacques, Martin-Albo, Justo, Martinez, Norman, Martinez Caicedo, David, Martynenko, Sergey, Mason, Katie, Mastbaum, Andrew, Masud, Mehedi, Matsuno, Shigenobu, Matthews, James, Mauger, Christopher, Mauri, Nicoletta, Mavrokoridis, Konstantinos, Mazza, Roberto, Mazzacane, Anna, Mazzucato, Edoardo, McCluskey, Elaine, McConkey, Nicola, McFarland, Kevin, McGrew, Clark, McNab, Andrew, Mefodiev, Alexander, Mehta, Poonam, Melas, Pantelis, Mellinato, Michele, Mena, Olga, Menary, Scott, Mendes Santos, Lucas, Mendez, Hector, Menegolli, A, Meng, Guang, Messier, Mark, Metcalf, William, Mewes, Matthew, Meyer, Holger, Miao, Ting, Michna, Gregory, Miedema, Thijs, Migenda, Jost, Milincic, Radovan, Miller, William, Mills, Joshua, Milne, Cody, Mineev, Oleg, Miranda, Omar, Miryala, Sandeep, Mishra, C Shekhar, Mishra, Sanjib R, Mislivec, Aaron, Mladenov, Dimitar, Mocioiu, Irina, Moffat, Kristian, Moggi, Niccolo, Mohanta, Rukmani, Mohayai, Tanaz, Mokhov, Nikolai, Molina, Jorge, Molina Bueno, Laura, Montanari, Alessandro, Montanari, Claudio, Montanari, David, Montano Zetina, Luis, Moon, Jarrett, Mooney, Michael, Moreno, Deywis, Morgan, Ben, Morris, Casandra, Mossey, Chris, Motuk, Erdem, Moura, Célio, Mousseau, Joel, Mu, Wei, Mualem, Leon, Mueller, Justin, Muether, Mathew, Mufson, Stuart, Muheim, Franz, Muir, Alan, Mulhearn, Mike, Muramatsu, Hajime, Murphy, Sebastien, Musser, Jim, Nachtman, Jane, Nagu, S., Nalbandyan, Mikayel, Nandakumar, Raja, Naples, Donna, Narita, Shinya, Navas-Nicolas, D., Nayak, Nitish, Nebot-Guinot, Miquel, Necib, Lina, Negishi, Kentaro, Nelson, Jeff, Nesbit, Jake, Nessi, Marzio, Newbold, David, Newcomer, Mitch, Newhart, Duane, Nichol, Ryan, Niner, Evan, Nishimura, Kurtis, Norman, Andrew, Northrop, Rich, Novella, Pau, Nowak, Jaroslaw, Oberling, Michael, Olivares Del Campo, Andres, Olivier, Andrew, Onel, Yasar, Onishchuk, Yuriy, Ott, Jordan, Pagani, Luca, Pakvasa, Sandip, Palamara, Ornella, Palestini, Sandro, Paley, Jonathan, Pallavicini, Marco, Palomares, Carmen, Pantic, Emilija, Paolone, Vittorio, Papadimitriou, Vaia, Papaleo, Riccardo, Papanestis, Antonis, Paramesvaran, Sudarshan, Parke, Stephen, Parsa, Zohreh, Parvu, Mihaela, Pascoli, Silvia, Pasqualini, Laura, Pasternak, Jaroslaw, Pater, Joleen, Patrick, Cheryl, Patrizii, Laura, Patterson, Ryan, Patton, Simon John, Patzak, Thomas, Paudel, Ajib, Paulos, Bob, Paulucci, Laura, Pavlovic, Zarko, Pawloski, Greg, Payne, David, Pec, Viktor, Peeters, Simon, Penichot, Yves, Pennacchio, Elisabetta, Penzo, Aldo, Peres, Orlando, Perry, James, Pershey, Daniel, Pessina, Gianluigi, Petrillo, Gianluca, Petta, Catia, Petti, Roberto, Piastra, Francesco, Pickering, Luke, Pietropaolo, Francesco, Pillow, James, Plunkett, Robert, Poling, Ronald, Pons, Xavier, Poonthottathil, Navaneeth, Pordes, Stephen, Potekhin, Maxim, Potenza, Renato, Potukuchi, B.V.K.S., Pozimski, Juergen, Pozzato, Michele, Prakash, Suprabh, Prakash, Tarun, Prince, Sebastien, Pugnere, Denis, Qi, K., Qian, Xin, Raaf, Jennifer L, Raboanary, R., Radeka, Veljko, Rademacker, Jonas, Radics, Balint, Rafique, Aleena, Raguzin, Eric, Rai, Mousam, Rajaoalisoa, Miriama, Rakhno, Igor, Rakotondramanana, H.T., Rakotondravohitra, Laza, Ramachers, Yorck A, Rameika, Regina, Ramson, Bryan, Rappoldi, A, Raselli, GL, Ratoff, Peter, Ravat, Sylvain, Razafinime, H., Real, Jean-Sebastien, Rebel, Brian, Redondo, David, Reggiani-Guzzo, Marina, Rehak, Tyler, Reichenbacher, Juergen, Reitzner, S, Renshaw, Andrew, Rescia, Sergio, Resnati, Filippo, Reynolds, Aidan, Riccobene, Giorgio, Rice, Logan, Rielage, Keith, Rigaut, Yann-Axel, Rivera, David, Rochester, Leon, Roda, Marco, Rodrigues, Philip, Rodriguez Alonso, Manual Jesus, Rodriguez Rondon, Jairo, Roeth, Alison J, Rogers, Hannah, Rosauro-Alcaraz, Salvador, Rossella, M, Rout, Jogesh, Roy, Samiran, Rubbia, Andre, Rubbia, Carlo, Russell, Brooke, Russell, James, Ruterbories, Daniel, Saakyan, Ruben, Sacerdoti, Sabrina, Safford, Twymun, Sahu, Narendra, Sala, Paola, Samios, Nicholas, Sanchez, Mayly, Sanders, David, Sankey, David, Santana, Samuel, Santos-Maldonado, Marvin, Saoulidou, Niki, Sapienza, Piera, Sarasty, Carlos, Sarcevic, Ina, Savage, Geoffrey, Savinov, Vladimir, Scaramelli, Alberto, Scarff, Andrew, Scarpelli, Andrea, Schaffer, Tom, Schellman, Heidi, Schlabach, Philip, Schmitz, David, Scholberg, Kate, Schukraft, Anne, Segreto, Ettore, Sensenig, Jon, Seong, Ilsoo, Sergi, Antonino, Sergiampietri, F., Sgalaberna, Davide, Shaevitz, Michael H, Shafaq, Sheeba, Shamma, M., Sharma, Hans, Sharma, Rahul, Shaw, Terri, Shepherd-Themistocleous, Claire, Shin, Seodong, Shooltz, Dean, Shrock, Robert, Simard, Laurent, Simos, Nikolaos, Sinclair, James, Sinev, Gleb, Sipos, Roland, Sippach, F W, Sirri, Gabriele, Sitraka, Andriaseta, Siyeon, Kim, Smargianaki, D., Smith, Erica, Smith, Paul, Smolik, Jan, Smy, Michael, Snopok, Pavel, Soares Nunes, Mônica, Sobel, Henry, Soderberg, Mitch, Solano Salinas, Carlos, Söldner-Rembold, Stefan, Solomey, Nicholas, Solovov, Vladimir, Sondheim, Walter, Sorel, Michel, Soto-Oton, Jose, Sousa, Alexandre, Soustruznik, Karel, Spagliardi, Fabio, Spanu, Maura, Spitz, Joshua, Spooner, Neil JC, Spurgeon, Kyle, Staley, Richard, Stancari, Michelle, Stanco, Luca, Steiner, Herbert M, Stewart, James, Stillwell, Ben, Stock, Jason, Stocker, Francesca, Stokes, Tyler, Strait, Matthew, Strauss, Thomas, Striganov, Sergei, Stuart, Alexander, Summers, Don, Surdo, Antonio, Susic, Vasja, Suter, Louise, Sutera, Concetta Maria, Svoboda, Robert, Szczerbinska, Barbara, Szelc, Andrzej, Talaga, Richard, Tanaka, Hirohisa, Tapia Oregui, Beatriz, Tapper, Alexander, Tariq, Salman, Tatar, E., Tayloe, Rex, Teklu, Abraham Meles, Tenti, Matteo, Terao, Kazuhiro, Ternes, Christoph, Terranova, Francesco, Testera, Gemma, Thea, Alessandro, Thompson, Joshua, Thorn, Craig, Timm, Steven C, Tonazzo, Alessandra, Torti, Marta, Tortola, Mariam, Tortorici, Francesco, Totani, Dante, Toups, Matthew, Touramanis, Christos, Trevor, Jason, Trzaska, Wladyslaw, Tsai, Yun-Tse, Tsamalaidze, Zviadi, Tsang, Ka Vang, Tsverava, Nikolozi, Tufanli, Serhan, Tull, Craig, Tyley, E., Tzanov, Martin, Uchida, Melissa, Urheim, Jon, Usher, Tracy, Vagins, Mark R, Vahle, Patricia, Valdiviesso, Gustavo, Valencia, E., Vallari, Zoya, Valle, Jose, Vallecorsa, Sofia, Van Berg, Rick, Van de Water, Richard, Vanegas Forero, David, Varanini, Filippo, Vargas, Danaisis, Varner, Gary, Vasel, Justin, Vasseur, Georges, Vaziri, Kamran, Ventura, Sandro, Verdugo, Antonio, Vergani, Stefano, Vermeulen, Milo, Verzocchi, Marco, Vieira de Souza, Henrique, Vignoli, Chiara, Vilela, Cristovao, Viren, Brett, Vrba, Tomas, Wachala, Tomasz, Waldron, Abigail, Wallbank, Michael, Wang, Hanguo, Wang, Jingbo, Wang, Yi, Wang, Yue, Warburton, Karl, Warner, David, Wascko, Morgan, Waters, David, Watson, Alan, Weatherly, Pierce, Weber, Alfons, Weber, Michele, Wei, Hanyu, Weinstein, Amanda, Wenman, Dan, Wetstein, Matthew, Yang, Shaokai, Zeller, Geralyn (Sam), While, M.R., White, Andy, Whitehead, Leigh, Whittington, Denver, Wilking, Michael, Wilkinson, Callum, Williams, Zachary, Wilson, Fergus, Wilson, Robert, Wolcott, Jeremy, Wongjirad, Taritree, Wood, Kevin, Wood, Lynn, Worcester, Elizabeth, Worcester, Matthew, Wret, Clarence, Wu, Wanwei, Xiao, Y., Yang, Guang, Yang, Tingjun, Yershov, Nikolai, Yonehara, Katsuya, Young, Tim, Yu, Bo, Yu, Jae, Zalesak, Jaroslav, Zambelli, Laura, Zamorano, Bruno, Zani, Andrea, Zazueta, Luis, Zeller, G.P., Zennamo, Joseph, Zeug, Kyle, Zhang, Chao, Zhao, Manhong, Zhivun, Elena, Zhu, Guanying, Zimmerman, Eric, Zito, Marco, Zucchelli, Stefano, Zuklin, Josef, Zutshi, Vishnu, Zwaska, Robert, Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), DUNE, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), and Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
safety ,Neutrino Oscillations. Neutrino detectors ,Physics - Instrumentation and Detectors ,hep-ex ,Physics::Instrumentation and Detectors ,engineering ,far detector ,FOS: Physical sciences ,Instrumentation and Detectors (physics.ins-det) ,fabrication ,time projection chamber: liquid argon ,High Energy Physics - Experiment ,High Energy Physics - Experiment (hep-ex) ,neutrino: deep underground detector ,quality ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,High Energy Physics::Experiment ,[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det] ,Detectors and Experimental Techniques ,physics.ins-det ,Particle Physics - Experiment ,activity report - Abstract
The preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decay -- these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our universe, its current state, and its eventual fate. The Deep Underground Neutrino Experiment (DUNE) is an international world-class experiment dedicated to addressing these questions as it searches for leptonic charge-parity symmetry violation, stands ready to capture supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector technical design report (TDR) describes the DUNE physics program and the technical designs of the single- and dual-phase DUNE liquid argon TPC far detector modules. Volume III of this TDR describes how the activities required to design, construct, fabricate, install, and commission the DUNE far detector modules are organized and managed. This volume details the organizational structures that will carry out and/or oversee the planned far detector activities safely, successfully, on time, and on budget. It presents overviews of the facilities, supporting infrastructure, and detectors for context, and it outlines the project-related functions and methodologies used by the DUNE technical coordination organization, focusing on the areas of integration engineering, technical reviews, quality assurance and control, and safety oversight. Because of its more advanced stage of development, functional examples presented in this volume focus primarily on the single-phase (SP) detector module., Minor corrections made for JINST submission, 209 pages, 55 figures (updated typos in Table A.5; corrected errors in author list)
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- 2020
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- View/download PDF
46. The CYGNUS Directional Dark Matter Experiment and Neutrino-Nucleus Scattering
- Author
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Spooner, Neil
- Subjects
directional dark matter detection ,reactor antineutrinos ,Astrophysics::High Energy Astrophysical Phenomena ,neutrinos ,CEvNS - Abstract
CYGNUS is a coordinated effort by dark matter direct search groups interested in directional signals, working towards design and build of a global network of directional WIMP experiments able to probe below the neutrino floor. As such, sensitivity is required to detection and measurement of Solar neutrino-nucleus scattering with directional information. The proposed technology is that of low pressure gas time projection chambers. Recent design work on CYGNUS to achieve this will be reviewed including new results on the essential issue of electron background discrimination and intrinsic backgrounds. The potential use of the UK's 1.5 GW Hartlepool reactor for a test run is outlined as well as other efforts in CYGNUS considering the potential for neutrino-nucleus scattering at low energies. Presented at the 2019 Magnificent CEvNS workshop.
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- 2019
- Full Text
- View/download PDF
47. Solid-phase microextraction for assessment of plasma protein binding, a complement to rapid equilibrium dialysis.
- Author
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Ahmad, Sheelan, Baker, Daniel, Murnane, Darragh, Spooner, Neil, and Gerhard, Ute
- Published
- 2021
- Full Text
- View/download PDF
48. Highlights from the 25th International Reid Bioanalytical Forum.
- Author
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Spooner, Neil, Nadarajah, Sankeetha, and Sangster, Tim
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- 2024
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49. In vitro testing of the hemaPEN microsampling device for the quantification of acetaminophen in human blood.
- Author
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Sen, Arundhuti, Gillett, Molly, Weaver, Lucy, Barfield, Matthew, Singh, Pawanbir, Lapierre, Florian, and Spooner, Neil
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- 2020
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50. Validation of methods for determining pediatric midazolam using wet whole blood and volumetric absorptive microsampling.
- Author
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Abu-Rabie, Paul, Neupane, Bikalpa, Spooner, Neil, Rudge, James, Denniff, Philip, Mulla, Hussain, and Pandya, Hitesh
- Published
- 2019
- Full Text
- View/download PDF
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