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8. Impact of the SARS-CoV2 pandemic dissemination on the management of neuroendocrine neoplasia in Italy: a report from the Italian Association for Neuroendocrine Tumors (Itanet)

Author

Panzuto, F., Maccauro, M., Campana, D., Faggiano, A., Massironi, S., Pusceddu, S., Spada, F., Ferone, D., Modica, R., Grana, C. M., Ferolla, P., Rinzivillo, M., Badalamenti, G., Zatelli, M. C., Gelsomino, F., De Carlo, E., Bartolomei, M., Brizzi, M. P., Cingarlini, S., Versari, A., Fanciulli, G., Arvat, E., Merola, E., Cives, M., Tafuto, S., Baldari, S., and Falconi, M.

Published
2021
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12. Emollient formulations containing antiseptics reduce effectively the level of Staphylococcus aureus on skin

Author

Spada F, Barnes TM, and Greive KA

Subjects
Staphylococcus aureus, atopic eczema, atopic dermatitis, benzalkonium chloride, triclosan, antimicrobial, antiseptic, emollient, Dermatology, RL1-803
Abstract

Fabrizio Spada, Tanya M Barnes, Kerryn A Greive Research & Development, Ego Pharmaceuticals, Braeside, Victoria, AustraliaCorrespondence: Fabrizio SpadaEgo Pharmaceuticals Pty Ltd, 21-31 Malcolm Road, Braeside, Victoria 3195, AustraliaTel +61 39 586 8874Fax +61 39 580 7647Email fabrizio.spada@egopharm.comBackground: Increased skin colonization by Staphylococcus aureus is associated with atopic eczema (AE) severity. Reduction of S. aureus levels on the skin results in an improvement in the clinical condition.Methods: The antimicrobial activity of topical products including a bath oil, cream, and wash combining antiseptics and emollients (A+E) was compared to products containing emollients only. The preference of patients with AE for A+E cream or emollient only cream to relieve symptoms of itching, erythema, and inflammation when applied three times daily for 10 days is evaluated. Repeat insult patch testing of the products is also conducted.Results: A significant reduction in microbial counts was found following use of A+E bath oil (4.09±0.32 vs 6.20±0.24 log10 cfu/mL S. aureus, P

Published
2019

13. Use of formulations for sensitive skin improves the visible signs of aging, including wrinkle size and elasticity

Author

Spada F, Lui AH, and Barnes TM

Subjects
hydration, elasticity, wrinkles, nicotinamide, avenanthramides, vitamin E, Dermatology, RL1-803
Abstract

Fabrizio Spada, Ada H Lui, Tanya M BarnesResearch & Development, Ego Pharmaceuticals, Braeside, Victoria 3195, AustraliaBackground: Sensitive skin affects an increasingly large proportion of the population and is less tolerant to frequent and prolonged use of cosmetics. This study investigates the antiaging effects of a skin care system developed for use on sensitive skin.Methods: A total of 30 healthy Caucasian females, aged 32–72, were enrolled in this double-blind randomized placebo-controlled split-face study. A routine consisting of twice daily topical applications of the test cleanser and test moisturizer or placebo or positive control products was followed for 28 days, with parameters measured at baseline and at 7-day intervals. Objective skin assessments for hydration, transepidermal water loss (TEWL), skin surface topography, elasticity and safety assessment were conducted.Results: Wrinkle surface, length and depth significantly improved by 34.8±4.7% (P

Published
2019

14. Skin hydration is significantly increased by a cream formulated to mimic the skin’s own natural moisturizing systems

Author

Spada F, Barnes TM, and Greive KA

Subjects
ceramide, moisturizer, stratum corneum, hydration, transepidermal water loss, natural moisturizing factor, Dermatology, RL1-803
Abstract

Fabrizio Spada, Tanya M Barnes, Kerryn A Greive Research and Development, Ego Pharmaceuticals Pty Ltd, Braeside, VIC, Australia Background: Moisturizers are topical products designed to improve and maintain the skin barrier function and to help prevent dry skin.Materials and methods: A new moisturizer (Ceramide cream) was formulated containing ingredients which mimic the skin’s own natural moisturizing systems. Corneometry was performed at baseline, 2, 4, 6 and 24 hours following a single application of Ceramide cream to healthy skin, and compared to three reference moisturizers available over-the-counter, and placebo. Transepidermal water loss (TEWL) was also measured following a single application of Ceramide cream compared to baseline, and its safety was assessed by repeat insult patch test, ophthalmologist and pediatric testing.Results: A single topical application of either the Ceramide cream or the three reference moisturizers resulted in a significant increase in skin hydration over time (P

Published
2018

18. Diversity and ethics in trauma and acute care surgery teams: results from an international survey

Author

Cobianchi L., Dal Mas F., Massaro M., Biffl W., Catena F., Coccolini F., Dionigi B., Dionigi P., Di Saverio S., Fugazzola P., Kluger Y., Leppaniemi A., Moore E. E., Sartelli M., Velmahos G., Woltz S., Angelos P., Ansaloni L., Abdelmalik A., Abebe N. S., Abu-Zidan F. M., Adam Y. A. Y., Adamou H., Agrusa A., Akin E., Alexandrino H., Ali S. M., Almeida P. M., Amico F., Ammendola M., Andreuccetti J., Aparicio-Sanchez D., Ardito A., Argenio G., Askevold I. H., Atanasov B. T., Augustin G., Awad S. S., Bagnoli C., Bains L., Balalis D., Baldini E., Baraket O., Barone M., Barreras J. A., Bellanova G., Biancuzzi H., Bignell M. B., Bini R., Bissacco D., Boati P., Bottari A., Bouliaris K., Brillantino A., Buonomo L. A., Buscemi S., Calu V., Campo Dall'Orto R., Campostrini S., Carvas J. M., Casoni Pattacini G., Celentano V., Ceresoli M., Chirica M., Cianci P., Cillara N., Cimbanassi S., Cioffi S. P. B., Colak E., Conti L., Dantas Costa S., D'Acapito F., Damaskos D., Das K., Davies R. J., De Beaux A. C., De Simone B., Demetrashvili Z., Demetriades A. K., Denicolai S., Di Buono G., Di Carlo I., Diaconescu B., Dibra R., Dios-Barbeito S., Dogjani A., Domanin M., D'Oria M., Duran Munoz-Cruzado V., East B., Ekwen G. T., Elbaih A. H., Escalera-Antezana J. P., Esposito G., Farre R., Ferrario di Tor Vajana A., Cordeiro Fonseca V., Forfori F., Fortuna L., Fradelos E., Fraga G. P., Fransvea P., Gachabayov M., Garcia Vazquez A. A., Ghannam W. M., Gioco R., Giraudo G., Giuffrida M., Giulii Capponi M., Gomes C. A., Teixeira Gonsaga R. A., Gonullu E., Goosen J., Goranovic T., Griffiths E. A., Haidar M. G., Hamid H. K. S., Harddastle T. C., Healey A. J., Hecker M., Hernandez Garcia E. F., Huaman E. C., Hutan M., Ioannidis O., Isik A., Ismail A. M. H., Ismail N., Jang J. Y., Kaafarani H. M. A., Kalipershad S. N. R., Kaplan L. J., Kara Y., Karamagioli E., Karamarkovia A., Kavalakat A. J., Kechagias A., Kenig J., Khan J. S., Khokha V., Klappenbach R., Kobe Y., Kong V., Korkolis D., Kurihara H., Kuriyama A., Landaluce-Olavarria A., Licari L., Litvin A., Loftus T. J., Lohsiriwat V., Lopes Moreira C. C., Lostoridis E., Luna A. T., Luppi D., Machain G. M., Maegele M., Maggiore D., Maier R. V., Manangi M., Manetti A., Mantoglu B., Mariani F., Marinis A., Sbalcheiro Mariot E. A., Marseglia G. R., Martellucci J., Martines G., Martinez Perez A., Mascagni P., Massalou D., Melo R. B., Miceli L., Mingoli A., Mishra T. S., Mohamedahmed A. Y. Y., Mohan R., Morales-Garcia D., Mustafa S. M. S., Naimzada M. D., Negoi I., Nguyen C., Nidaw M. K., Nigri G., Ogundipe H. D., Oliveri C., Olmi S., Pagani L., Palomba G., Pantalone D., Panyko A., Paolillo C., Papis D., Pararas N., Pata F., Paterson-Brown S., Pavone G., Pecchini F., Pellino G., Pelloni M., Peloso A., Perea del Pozo E., Goncalves Pereira R., Monteiro Pereira B., Lizarazu Perez A., Perrone G., Pesce A., Petracca G., Piccoli M., Piccolo D., Picetti E., Pikoulis E., Pintar T., Pirozzolo G., Podda M., Previtali P., Privitera F., Punzo C., Quiodettis M. A., Qvist N., Rahim R., Reinisch-Liese A., Rodriguez-Luna M. R., Roizblatt D., Roscio F. P. M., Rossi S., Ruta F., Sakakushev B. E., Salamea J. C., Sall I., Sammartano F., Sanchez Arteaga A., Sanchez-Cordero S., Sasia D., Sawyer R. G., Seretis C., Serradilla-Martin M., Shelat V. G., Shlyapnikov S., Simoes R. L., Siribumrungwong B., Slavchev M., Solaini L., Soldini G., Soreide K., Spada F., Stahel P., Sydorchuk L., Sydorchuk R., Syed A. M., Tallon-Aguilar L., Tan J. H., Tan E., Tarasconi A., Tartaglia D., Tartaglia N., Taylor J., Tebala G. D., Teuben M., Tolonen M., Tomasicchio G., Triantafyllou T., Trigiante G., Turrado-Rodriguez V., Tutino R., Uccelli M., Ugarte-Sierra B., Ukkonen M., Vassiliu P. G., Verde J. M., Veroux M., Vilallonga R., Visconti D., Waledziak M., Wannatoop T., Widmer L. W., Wilson M. S. J., Wong T. H., Xenaki S., Yu B., Yule S., Zakaria A. D., Zambrano D. A., Zese M., Cobianchi, L, Dal Mas, F, Massaro, M, Biffl, W, Catena, F, Coccolini, F, Dionigi, B, Dionigi, P, Di Saverio, S, Fugazzola, P, Kluger, Y, Leppaniemi, A, Moore, E, Sartelli, M, Velmahos, G, Woltz, S, Angelos, P, Ansaloni, L, Abdelmalik, A, Abebe, N, Abu-Zidan, F, Adam, Y, Adamou, H, Agrusa, A, Akin, E, Alexandrino, H, Ali, S, Almeida, P, Amico, F, Ammendola, M, Andreuccetti, J, Aparicio-Sanchez, D, Ardito, A, Argenio, G, Askevold, I, Atanasov, B, Augustin, G, Awad, S, Bagnoli, C, Bains, L, Balalis, D, Baldini, E, Baraket, O, Barone, M, Barreras, J, Bellanova, G, Biancuzzi, H, Bignell, M, Bini, R, Bissacco, D, Boati, P, Bottari, A, Bouliaris, K, Brillantino, A, Buonomo, L, Buscemi, S, Calu, V, Campo Dall'Orto, R, Campostrini, S, Carvas, J, Casoni Pattacini, G, Celentano, V, Ceresoli, M, Chirica, M, Cianci, P, Cillara, N, Cimbanassi, S, Cioffi, S, Colak, E, Conti, L, Dantas Costa, S, D'Acapito, F, Damaskos, D, Das, K, Davies, R, De Beaux, A, De Simone, B, Demetrashvili, Z, Demetriades, A, Denicolai, S, Di Buono, G, Di Carlo, I, Diaconescu, B, Dibra, R, Dios-Barbeito, S, Dogjani, A, Domanin, M, D'Oria, M, Duran Munoz-Cruzado, V, East, B, Ekwen, G, Elbaih, A, Escalera-Antezana, J, Esposito, G, Farre, R, Ferrario di Tor Vajana, A, Cordeiro Fonseca, V, Forfori, F, Fortuna, L, Fradelos, E, Fraga, G, Fransvea, P, Gachabayov, M, Garcia Vazquez, A, Ghannam, W, Gioco, R, Giraudo, G, Giuffrida, M, Giulii Capponi, M, Gomes, C, Teixeira Gonsaga, R, Gonullu, E, Goosen, J, Goranovic, T, Griffiths, E, Haidar, M, Hamid, H, Harddastle, T, Healey, A, Hecker, M, Hernandez Garcia, E, Huaman, E, Hutan, M, Ioannidis, O, Isik, A, Ismail, A, Ismail, N, Jang, J, Kaafarani, H, Kalipershad, S, Kaplan, L, Kara, Y, Karamagioli, E, Karamarkovia, A, Kavalakat, A, Kechagias, A, Kenig, J, Khan, J, Khokha, V, Klappenbach, R, Kobe, Y, Kong, V, Korkolis, D, Kurihara, H, Kuriyama, A, Landaluce-Olavarria, A, Licari, L, Litvin, A, Loftus, T, Lohsiriwat, V, Lopes Moreira, C, Lostoridis, E, Luna, A, Luppi, D, Machain, G, Maegele, M, Maggiore, D, Maier, R, Manangi, M, Manetti, A, Mantoglu, B, Mariani, F, Marinis, A, Sbalcheiro Mariot, E, Marseglia, G, Martellucci, J, Martines, G, Martinez Perez, A, Mascagni, P, Massalou, D, Melo, R, Miceli, L, Mingoli, A, Mishra, T, Mohamedahmed, A, Mohan, R, Morales-Garcia, D, Mustafa, S, Naimzada, M, Negoi, I, Nguyen, C, Nidaw, M, Nigri, G, Ogundipe, H, Oliveri, C, Olmi, S, Pagani, L, Palomba, G, Pantalone, D, Panyko, A, Paolillo, C, Papis, D, Pararas, N, Pata, F, Paterson-Brown, S, Pavone, G, Pecchini, F, Pellino, G, Pelloni, M, Peloso, A, Perea del Pozo, E, Goncalves Pereira, R, Monteiro Pereira, B, Lizarazu Perez, A, Perrone, G, Pesce, A, Petracca, G, Piccoli, M, Piccolo, D, Picetti, E, Pikoulis, E, Pintar, T, Pirozzolo, G, Podda, M, Previtali, P, Privitera, F, Punzo, C, Quiodettis, M, Qvist, N, Rahim, R, Reinisch-Liese, A, Rodriguez-Luna, M, Roizblatt, D, Roscio, F, Rossi, S, Ruta, F, Sakakushev, B, Salamea, J, Sall, I, Sammartano, F, Sanchez Arteaga, A, Sanchez-Cordero, S, Sasia, D, Sawyer, R, Seretis, C, Serradilla-Martin, M, Shelat, V, Shlyapnikov, S, Simoes, R, Siribumrungwong, B, Slavchev, M, Solaini, L, Soldini, G, Soreide, K, Spada, F, Stahel, P, Sydorchuk, L, Sydorchuk, R, Syed, A, Tallon-Aguilar, L, Tan, J, Tan, E, Tarasconi, A, Tartaglia, D, Tartaglia, N, Taylor, J, Tebala, G, Teuben, M, Tolonen, M, Tomasicchio, G, Triantafyllou, T, Trigiante, G, Turrado-Rodriguez, V, Tutino, R, Uccelli, M, Ugarte-Sierra, B, Ukkonen, M, Vassiliu, P, Verde, J, Veroux, M, Vilallonga, R, Visconti, D, Waledziak, M, Wannatoop, T, Widmer, L, Wilson, M, Wong, T, Xenaki, S, Yu, B, Yule, S, Zakaria, A, Zambrano, D, Zese, M, Cobianchi L., Dal Mas F., Massaro M., Biffl W., Catena F., Coccolini F., Dionigi B., Dionigi P., Di Saverio S., Fugazzola P., Kluger Y., Leppaniemi A., Moore E.E., Sartelli M., Velmahos G., Woltz S., Angelos P., Ansaloni L., Abdelmalik A., Abebe N.S., Abu-Zidan F.M., Adam Y.A.Y., Adamou H., Agrusa A., Akin E., Alexandrino H., Ali S.M., Almeida P.M., Amico F., Ammendola M., Andreuccetti J., Aparicio-Sanchez D., Ardito A., Argenio G., Askevold I.H., Atanasov B.T., Augustin G., Awad S.S., Bagnoli C., Bains L., Balalis D., Baldini E., Baraket O., Barone M., Barreras J.A., Bellanova G., Biancuzzi H., Bignell M.B., Bini R., Bissacco D., Boati P., Bottari A., Bouliaris K., Brillantino A., Buonomo L.A., Buscemi S., Calu V., Campo Dall'Orto R., Campostrini S., Carvas J.M., Casoni Pattacini G., Celentano V., Ceresoli M., Chirica M., Cianci P., Cillara N., Cimbanassi S., Cioffi S.P.B., Colak E., Conti L., Dantas Costa S., D'Acapito F., Damaskos D., Das K., Davies R.J., De Beaux A.C., De Simone B., Demetrashvili Z., Demetriades A.K., Denicolai S., Di Buono G., Di Carlo I., Diaconescu B., Dibra R., Dios-Barbeito S., Dogjani A., Domanin M., D'Oria M., Duran Munoz-Cruzado V., East B., Ekwen G.T., Elbaih A.H., Escalera-Antezana J.P., Esposito G., Farre R., Ferrario di Tor Vajana A., Cordeiro Fonseca V., Forfori F., Fortuna L., Fradelos E., Fraga G.P., Fransvea P., Gachabayov M., Garcia Vazquez A.A., Ghannam W.M., Gioco R., Giraudo G., Giuffrida M., Giulii Capponi M., Gomes C.A., Teixeira Gonsaga R.A., Gonullu E., Goosen J., Goranovic T., Griffiths E.A., Haidar M.G., Hamid H.K.S., Harddastle T.C., Healey A.J., Hecker M., Hernandez Garcia E.F., Huaman E.C., Hutan M., Ioannidis O., Isik A., Ismail A.M.H., Ismail N., Jang J.Y., Kaafarani H.M.A., Kalipershad S.N.R., Kaplan L.J., Kara Y., Karamagioli E., Karamarkovia A., Kavalakat A.J., Kechagias A., Kenig J., Khan J.S., Khokha V., Klappenbach R., Kobe Y., Kong V., Korkolis D., Kurihara H., Kuriyama A., Landaluce-Olavarria A., Licari L., Litvin A., Loftus T.J., Lohsiriwat V., Lopes Moreira C.C., Lostoridis E., Luna A.T., Luppi D., Machain G.M., Maegele M., Maggiore D., Maier R.V., Manangi M., Manetti A., Mantoglu B., Mariani F., Marinis A., Sbalcheiro Mariot E.A., Marseglia G.R., Martellucci J., Martines G., Martinez Perez A., Mascagni P., Massalou D., Melo R.B., Miceli L., Mingoli A., Mishra T.S., Mohamedahmed A.Y.Y., Mohan R., Morales-Garcia D., Mustafa S.M.S., Naimzada M.D., Negoi I., Nguyen C., Nidaw M.K., Nigri G., Ogundipe H.D., Oliveri C., Olmi S., Pagani L., Palomba G., Pantalone D., Panyko A., Paolillo C., Papis D., Pararas N., Pata F., Paterson-Brown S., Pavone G., Pecchini F., Pellino G., Pelloni M., Peloso A., Perea del Pozo E., Goncalves Pereira R., Monteiro Pereira B., Lizarazu Perez A., Perrone G., Pesce A., Petracca G., Piccoli M., Piccolo D., Picetti E., Pikoulis E., Pintar T., Pirozzolo G., Podda M., Previtali P., Privitera F., Punzo C., Quiodettis M.A., Qvist N., Rahim R., Reinisch-Liese A., Rodriguez-Luna M.R., Roizblatt D., Roscio F.P.M., Rossi S., Ruta F., Sakakushev B.E., Salamea J.C., Sall I., Sammartano F., Sanchez Arteaga A., Sanchez-Cordero S., Sasia D., Sawyer R.G., Seretis C., Serradilla-Martin M., Shelat V.G., Shlyapnikov S., Simoes R.L., Siribumrungwong B., Slavchev M., Solaini L., Soldini G., Soreide K., Spada F., Stahel P., Sydorchuk L., Sydorchuk R., Syed A.M., Tallon-Aguilar L., Tan J.H., Tan E., Tarasconi A., Tartaglia D., Tartaglia N., Taylor J., Tebala G.D., Teuben M., Tolonen M., Tomasicchio G., Triantafyllou T., Trigiante G., Turrado-Rodriguez V., Tutino R., Uccelli M., Ugarte-Sierra B., Ukkonen M., Vassiliu P.G., Verde J.M., Veroux M., Vilallonga R., Visconti D., Waledziak M., Wannatoop T., Widmer L.W., Wilson M.S.J., Wong T.H., Xenaki S., Yu B., Yule S., Zakaria A.D., Zambrano D.A., Zese M., HUS Abdominal Center, II kirurgian klinikka, and Helsinki University Hospital Area

Subjects
Ethics, Patient Care Team, Diversity, Acute care surgery, 3126 Surgery, anesthesiology, intensive care, radiology, Trauma surgery, Settore SECS-P/10 - Organizzazione Aziendale, Settore MED/18 - Chirurgia Generale, Settore SECS-P/07 - Economia Aziendale, Surveys and Questionnaires, Emergency Medicine, Humans, Surveys and Questionnaire, Surgery, Team dynamics, Ethic, Team dynamic, Human
Abstract

Background Investigating the context of trauma and acute care surgery, the article aims at understanding the factors that can enhance some ethical aspects, namely the importance of patient consent, the perceptiveness of the ethical role of the trauma leader, and the perceived importance of ethics as an educational subject. Methods The article employs an international questionnaire promoted by the World Society of Emergency Surgery. Results Through the analysis of 402 fully filled questionnaires by surgeons from 72 different countries, the three main ethical topics are investigated through the lens of gender, membership of an academic or non-academic institution, an official trauma team, and a diverse group. In general terms, results highlight greater attention paid by surgeons belonging to academic institutions, official trauma teams, and diverse groups. Conclusions Our results underline that some organizational factors (e.g., the fact that the team belongs to a university context or is more diverse) might lead to the development of a higher sensibility on ethical matters. Embracing cultural diversity forces trauma teams to deal with different mindsets. Organizations should, therefore, consider those elements in defining their organizational procedures. Level of evidence Trauma and acute care teams work under tremendous pressure and complex circumstances, with their members needing to make ethical decisions quickly. The international survey allowed to shed light on how team assembly decisions might represent an opportunity to coordinate team member actions and increase performance.

Published
2022

19. Randomized trial on adjuvant treatment with FOLFIRI followed by docetaxel and cisplatin versus 5-fluorouracil and folinic acid for radically resected gastric cancer

Author

Floriani, I., Rulli, E., Cropalato Di Tullio, M., Poli, D., Galli, F., Biagioli, E., De Simone, I., Mangano, S., Tonato, M., Zucca, E., Valsecchi, M.G., Bajetta, E., Di Bartolomeo, M., Labianca, R., Amadori, D., Falcone, A., Di Costanzo, F., Daniele, B., Pinto, C., Comella, G., Nitti, D., Mini, E., De Placido, S., Marchet, A., Catena, L., Schiavo, M., Pinotti, G., Proserpio, I., Rosati, G., Bordonaro, R., Cordio, S., Burrafato, G., Bochicchio, A.M., Aieta, M., Fazio, N., Spada, F., Amoroso, V., Marini, G., Soto Parra, H., Novello, G., Massidda, B., Ionta, M.T., Comandè, M., Venezia, R., Bertolini, A., Menatti, E., Zanlorenzi, L., Colombo, A., Iop, A., Bonura, S., Mazza, E., Viganò, M., Ardizzoia, A., Dell'Oro, S., Lo Re, G., Santeufemia, D., Buonadonna, A., Luisi, D., Ucci, G., Di Lucca, G., Bonetti, A., Bergamo, F., Alù, M., Vastola, F., Marchetti, P., Corsi, D.C., Massa, E., Di Pinto, G., Duro, M., Oliani, C., Franchini, M., Inzoli, A., Gebbia, N., Repetto, L., Rota, S., Frontini, L., Mosconi, S., Quadri, A., De Grossi, S., Bidoli, P., Cazzaniga, M.E., Villa, F., Foa, P., Ferrari, D., Aitini, E., Rabbi, C., Barni, S., Petrelli, F., Giordano, M., Luchena, G., Pirovano, M., Nasisi, A., Catalano, V., Giordani, P., Zaniboni, A., Leone, F., Ferrario, S., Beretta, G.D., Menichetti, E.T., Conte, D., Mari, D., Giannicola, R., Pierantoni, C., Luporini, A.G., Ravaioli, A., Tassinari, D., Nicolini, M., Frassineti, G.L., Turci, D., Zumaglini, F., Tamberi, S., Piancastelli, A., Cruciani, G., Landi, L., Minuti, G., Cantore, M., Orlandi, M., Mambrini, A., Ciarlo, A., Cavaciocchi, D., Del Monte, F., Ricci, S., Brunetti, M.I., Lencioni, M., Sisani, M., Sozzi, P., Granetto, C., Chiara, S., Galetto, A.S., Ribecco, A.S., DeCensi, A., Ciuffreda, L., Baldini, E.E., Camisa, R., Todeschini, R., Santoro, A., Rimassa, L., Carnaghi, C., Pressiani, T., Boni, C., Rondini, E., Gnoni, R., Gasperoni, S., Cavanna, L., Palladino, M.A., Mattioli, R., Laici, G., Pucci, F., Alessio, M.D., Bernardini, I., Tomasello, G., Baldino, G., Rossetti, R., Giaquinta, S., Di Fabio, F., Rijas Llimpe, F.L., Brandes, A.A., Marzola, M., Montesarchio, V., Rea, A., Genua, G., Casaretti, R., Silvestro, L., Montano, M., Sarobba, M.G., Sanna, G., Filippelli, G., Dima, G., Greco, E., Roselli, M., Natale, D., Condemi, G., Fumi, G., Tafuto, S., Masullo, P., Tiberio, G., de Manzoni, G., Fiorentini, G., Mazzanti, R., Carlomagno, C., De Stefano, A., Cartenì, G., and Otero, M.

Published
2014
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20. Promising targetable biomarkers in pancreatic neuroendocrine tumours.

Author

Borghesani, M., Gervaso, L., Cella, C.A., Benini, L., Ciardiello, D., Algeri, L., Ferrero, A., Valenza, C., Guidi, L., Zampino, MG., Spada, F., and Fazio, N.

Subjects
NEUROENDOCRINE tumors, LITERATURE reviews, DRUG efficacy, TREATMENT effectiveness, HEAT shock proteins
Abstract

In the treatment scenario of PanNETs-targeted therapies are desired but limited, as rarity and heterogeneity on PanNETs pose limitations to their development. We performed a literature review searching for promising druggable biomarkers and potential treatments to be implemented in the next future. We focused on treatments which have already reached clinical experimentation, although in early phases. Six targets were identified, namely Hsp90, HIFa, HDACs, CDKs, uPAR, and DDR. Even though biological rational is strong, so far reported efficacy outcomes are quite disappointing. The reason of that should be searched in the patients' heterogeneity, lack of biomarker selection, poor knowledge of interfering mechanisms as well as difficulties in patients accrual. Moreover, different ways to assess treatment efficacy should be considered, other than response rate, in light of the more indolent nature of NETs. Development of targeted treatments in PanNETs is still an uncovered area, far behind other more frequent cancers. Rarity of NETs led to accrual of unselected populations, possibly jeopardizing the drug efficacy. Better patients' selection, both in terms of topography, grading and biomarkers is crucial and will help understanding which role targeted therapies can really play in these tumors. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Nationwide multidisciplinary consensus on the clinical management of Merkel cell carcinoma: a Delphi panel

Author

Spada F., Bossi P., Caraco C., Sileni V. C., Dei Tos A. P., Fazio N., Grignani G., Maio M., Quaglino P., Queirolo P., Ascierto P. A., Antonini Cappellini G. C., Antonuzzo L., Badalamenti G., Barberis M., Bassetto F., Berardi R., Berruti A., Bongiovanni A., Bonomo P., Borgognoni L., Borzillo V., Bruder F., Campana D., Consoli F., Cordova A., Depenni R., Di Giacomo A. M., Fabbrocini G., Fargnoli M. C., Ferraresi V., Ferrau F., Fierro M. T., Gatti M., Gelsomino F., Giuffrida D., Graziano P., Gregorelli C., Guida M., Massi D., Mazzarotto R., Milesi L., Minisini A. M., Morgese F., Muto P., Palmieri G., Patuzzo R., Pellacani G., Picciotto F., Pigozzo J., Pimpinelli N., Poletti P., Repetto L., Rinaldi G., Rubegni P., Rubino G., Spagnolo F., Tagliaferri L., Tanda E., Tronconi M. C., Tucci M., Valente M., Vincenzi B., Zalaudek I., Spada F., Bossi P., Caraco C., Sileni V.C., Dei Tos A.P., Fazio N., Grignani G., Maio M., Quaglino P., Queirolo P., Ascierto P.A., Antonini Cappellini G.C., Antonuzzo L., Badalamenti G., Barberis M., Bassetto F., Berardi R., Berruti A., Bongiovanni A., Bonomo P., Borgognoni L., Borzillo V., Bruder F., Campana D., Consoli F., Cordova A., Depenni R., Di Giacomo A.M., Fabbrocini G., Fargnoli M.C., Ferraresi V., Ferrau F., Fierro M.T., Gatti M., Gelsomino F., Giuffrida D., Graziano P., Gregorelli C., Guida M., Massi D., Mazzarotto R., Milesi L., Minisini A.M., Morgese F., Muto P., Palmieri G., Patuzzo R., Pellacani G., Picciotto F., Pigozzo J., Pimpinelli N., Poletti P., Repetto L., Rinaldi G., Rubegni P., Rubino G., Spagnolo F., Tagliaferri L., Tanda E., Tronconi M.C., Tucci M., Valente M., Vincenzi B., and Zalaudek I.

Subjects
Pharmacology, Cancer Research, Skin Neoplasms, Immunology, Carcinoma, Carcinoma, Merkel Cell, Oncology, Italy, Merkel cell polyomavirus, Merkel Cell, Molecular Medicine, Immunology and Allergy, immunotherapy, radiotherapy, skin neoplasms, Humans, Immunotherapy
Abstract

Merkel cell carcinoma (MCC) is a rare and highly aggressive cutaneous neuroendocrine carcinoma. The MCC incidence rate has rapidly grown over the last years, with Italy showing the highest increase among European countries. This malignancy has been the focus of active scientific research over the last years, focusing mainly on pathogenesis, new therapeutic trials and diagnosis. A national expert board developed 28 consensus statements that delineated the evolution of disease management and highlighted the paradigm shift towards the use of immunological strategies, which were then presented to a national MCC specialists panel for review. Sixty-five panelists answered both rounds of the questionnaire. The statements were divided into five areas: a high level of agreement was reached in the area of guidelines and multidisciplinary management, even if in real life the multidisciplinary team was not always represented by all the specialists. In the diagnostic pathway area, imaging played a crucial role in diagnosis and initial staging, planning for surgery or radiation therapy, assessment of treatment response and surveillance of recurrence and metastases. Concerning diagnosis, the usefulness of Merkel cell polyomavirus is recognized, but the agreement and consensus regarding the need for cytokeratin evaluation appears greater. Regarding the areas of clinical management and follow-up, patients with MCC require customized treatment. There was a wide dispersion of results and the suggestion to increase awareness about the adjuvant radiation therapy. The panelists unanimously agreed that the information concerning avelumab provided by the JAVELIN Merkel 200 study is adequate and reliable and that the expanded access program data could have concrete clinical implications. An immunocompromised patient with advanced MCC can be treated with immunotherapy after multidisciplinary risk/benefit assessment, as evidenced by real-world analysis and highlighted in the guidelines. A very high consensus regarding the addition of radiotherapy to treat the ongoing focal progression of immunotherapy was observed. This paper emphasizes the importance of collaboration and communication among the interprofessional team members and encourages managing patients with MCC within dedicated multidisciplinary teams. New insights in the treatment of this challenging cancer needs the contribution of many and different experts.

Published
2022

25. Corrigendum to ‘Coronavirus disease 2019 in patients with neuroendocrine neoplasms: Preliminary results of the INTENSIVE study’ [European Journal of Cancer 154 (2021) 246-252] (European Journal of Cancer (2021) 154(246-252) (S0959804921004044), (10.1016/j.ejca.2021.06.029))

Author

Fazio, N. Gervaso, L. Halfdanarson, T.R. La Salvia, A. Hofland, J. Hernando, J. Sonbol, M.B. Garcia-Carbonero, R. Capdevila, J. de Herder, W.W. Koumarianou, A. Kaltsas, G. Rossi, M. Grozinsky-Glasberg, S. Oleinikov, K. Boselli, S. Tamayo, D. Bagnardi, V. Laffi, A. Rubino, M. Spada, F.

Abstract

The authors regret that the world map presented in Figure 1 was incomplete. Please see the correct image for Fig 1 below. This has also been updated in the online article. [Figure presented] The authors would like to apologise for any inconvenience caused. © 2021 Elsevier Ltd

Published
2022

31. Randomized trial on adjuvant treatment with FOLFIRI followed by docetaxel and cisplatin versus 5-fluorouracil and folinic acid for radically resected gastric cancer

Author

Bajetta, E., Floriani, I., Di Bartolomeo, M., Labianca, R., Falcone, A., Di Costanzo, F., Comella, G., Amadori, D., Pinto, C., Carlomagno, C., Nitti, D., Daniele, B., Mini, E., Poli, D., Santoro, A., Mosconi, S., Casaretti, R., Boni, C., Pinotti, G., Bidoli, P., Landi, L., Rosati, G., Ravaioli, A., Cantore, M., Di Fabio, F., Aitini, E., Marchet, A., Floriani, I., Rulli, E., Cropalato Di Tullio, M., Poli, D., Galli, F., Biagioli, E., De Simone, I., Poli, D., Mangano, S., Tonato, M., Zucca, E., Valsecchi, MG., Floriani, I., Bajetta, E., Di Bartolomeo, M., Labianca, R., Amadori, D., Falcone, A., Di Costanzo, F., Daniele, B., Pinto, C., Comella, G., Nitti, D., Mini, E., De Placido, S., Marchet, A., Bajetta, E., Di Bartolomeo, M., Catena, L., Schiavo, M., Pinotti, G., Proserpio, I., Rosati, G., Bordonaro, R., Cordio, S., Burrafato, G., Bochicchio, A.M., Aieta, M., Fazio, N., Spada, F., Amoroso, V., Marini, G., Soto Parra, H., Novello, G., Massidda, B., Ionta, M.T., Comandè, M., Venezia, R., Bertolini, A., Menatti, E., Zanlorenzi, L., Colombo, A., Iop, A., Bonura, S., Mazza, E., Viganò, M., Ardizzoia, A., DellʼOro, S., Lo Re, G., Santeufemia, D., Buonadonna, A., Luisi, D., Ucci, G., Di Lucca, G., Bonetti, A., Bergamo, F., Alù, M., Vastola, F., Marchetti, P., Corsi, D.C., Massa, E., Di Pinto, G., Duro, M., Oliani, C., Franchini, M., Inzoli, A., Gebbia, N., Repetto, L., Rota, S., Frontini, L., Labianca, R., Mosconi, S., Quadri, A., De Grossi, S., Bidoli, P., Cazzaniga, M.E., Villa, F., Foa, P., Ferrari, D., Aitini, E., Rabbi, C., Barni, S., Petrelli, F., Giordano, M., Luchena, G., Pirovano, M., Nasisi, A., Catalano, V., Giordani, P., Zaniboni, A., Leone, F., Ferrario, S., Beretta, G.D., Menichetti, E.T., Conte, D., Mari, D., Giannicola, R., Pierantoni, C., Luporini, A.G., Ravaioli, A., Tassinari, D., Nicolini, M., Amadori, D., Frassineti, G.L., Turci, D., Zumaglini, F., Tamberi, S., Piancastelli, A., Cruciani, G., Falcone, A., Landi, L., Minuti, G., Cantore, M., Orlandi, M., Mambrini, A., Ciarlo, A., Cavaciocchi, D., Del Monte, F., Ricci, S., Brunetti, M.I., Lencioni, M., Sisani, M., Sozzi, P., Granetto, C., Chiara, S., Galetto, A.S., Ribecco, A.S., DeCensi, A., Ciuffreda, L., Baldini, E.E., Camisa, R., Todeschini, R., Santoro, A., Rimassa, L., Carnaghi, C., Pressiani, T., Boni, C., Rondini, E., Gnoni, R., Di Costanzo, F., Gasperoni, S., Cavanna, L., Palladino, M.A., Mattioli, R., Laici, G., Pucci, F., Alessio, M.D., Bernardini, I., Tomasello, G., Baldino, G., Rossetti, R., Giaquinta, S., Pinto, C., Di Fabio, F., Rijas Llimpe, F.L., Brandes, A.A., Marzola, M., Montesarchio, V., Rea, A., Daniele, B., Genua, G., Casaretti, R., Silvestro, L., Montano, M., Sarobba, M.G., Sanna, G., Filippelli, G., Dima, G., Greco, E., Roselli, M., Natale, D., Condemi, G., Fumi, G., Tafuto, S., Masullo, P., Nitti, D., Marchet, A., Tiberio, G., de Manzoni, G., Fiorentini, G., Mazzanti, R., Carlomagno, C., De Stefano, A., Cartenì, G., and Otero, M.

Published
2014
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37. 1199P MAVERIC: Phase II randomized study of everolimus as maintenance therapy for metastatic neuroendocrine neoplasms (mNEN) with pulmonary or gastroenteropancreatic (GEP) origin. Results on behalf of the GOIRC

Author

Antonuzzo, L., Pillozzi, S., Marconcini, R., Spada, F., Gelsomino, F., Amoroso, V., cosso, F., messerini, L., Zepponi, F., Scolari, F., Pellegrini, E., Sparano, C., Lavacchi, D., Brugia, M., Giommoni, E., Massaro, G., Milione, M., Di Costanzo, F., Boni, L., and Fazio, N.

Published
2023
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38. The Aarhus Red Giants Challenge I:Stellar structures in the red giant branch phase

Author

Silva Aguirre, V., Christensen-Dalsgaard, J., Cassisi, S., Miller Bertolami, M., Serenelli, A. M., Stello, D., Weiss, A., Angelou, G., Jiang, C., Lebreton, Y., Spada, F., Bellinger, E. P., Deheuvels, S., Ouazzani, R. M., Pietrinferni, A., Mosumgaard, J. R., Townsend, R. H. D., Battich, T., Bossini, D., Constantino, T., Eggenberger, P., Hekker, S., Mazumdar, A., Miglio, A., Nielsen, K. B., and Salaris, M.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics::Solar and Stellar Astrophysics, Astrophysics::Earth and Planetary Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics::Galaxy Astrophysics
Abstract

(Abridged). We introduce the Aarhus Red Giants Challenge, a series of detailed comparisons between widely used stellar evolution and oscillation codes aiming at establishing the minimum level of uncertainties in properties of red giants arising solely from numerical implementations. Using 9 state-of-the-art stellar evolution codes, we defined a set of input physics and physical constants for our calculations and calibrated the convective efficiency to a specific point on the main sequence. We produced evolutionary tracks and stellar structure models at fixed radius along the red-giant branch for masses of 1.0 M$_\odot$, 1.5 M$_\odot$, 2.0 M$_\odot$, and 2.5 M$_\odot$, and compared the predicted stellar properties. Once models have been calibrated on the main sequence we find a residual spread in the predicted effective temperatures across all codes of ~20 K at solar radius and ~30-40 K in the RGB regardless of the considered stellar mass. The predicted ages show variations of 2-5% (increasing with stellar mass) which we track down to differences in the numerical implementation of energy generation. The luminosity of the RGB-bump shows a spread of about 10% for the considered codes, which translates into magnitude differences of ~0.1 mag in the optical V-band. We also compare the predicted [C/N] abundance ratio and found a spread of 0.1 dex or more for all considered masses. Our comparisons show that differences at the level of a few percent still remain in evolutionary calculations of red giants branch stars despite the use of the same input physics. These are mostly due to differences in the energy generation routines and interpolation across opacities, and call for further investigations on these matters in the context of using properties of red giants as benchmarks for astrophysical studies.

Published
2019

39. Search for Cosmic-Ray Electron and Positron Anisotropies with Seven Years of Fermi Large Area Telescope Data

Author

Abdollahi, S., Ackermann, Markus, Bonino, R., Bottacini, E., Brandt, T. J., Bruel, P., Buson, S., Caragiulo, M., Cavazzuti, E., Chekhtman, A., Ciprini, S., Costanza, Francesco, Ajello, M., Cuoco, A., Cutini, S., D’Ammando, F., de Palma, F., Desiante, R., Digel, S. W., Di Lalla, N., Di Mauro, M., Di Venere, L., Donaggio, B., Albert, A., Drell, P. S., Favuzzi, C., Focke, W. B., Fukazawa, Y., Funk, S., Fusco, P., Gargano, F., Gasparrini, D., Giglietto, N., Giordano, F., Atwood, W. B., Giroletti, M., Green, D., Guiriec, S., Harding, A. K., Jogler, T., Jóhannesson, G., Kamae, T., Kuss, M., Larsson, S., Latronico, L., Baldini, L., Li, J., Longo, F., Loparco, F., Lubrano, P., Magill, J. D., Malyshev, D., Manfreda, A., Mazziotta, M. N., Meehan, M., Michelson, P. F., Barbiellini, G., Mitthumsiri, W., Mizuno, T., Moiseev, A. A., Monzani, M. E., Morselli, A., Negro, M., Nuss, E., Ohsugi, T., Omodei, N., Paneque, D., Bellazzini, R., Perkins, J. S., Pesce-Rollins, M., Piron, F., Pivato, G., Principe, G., Rainò, S., Rando, R., Razzano, M., Reimer, A., Reimer, O., Bissaldi, E., Sgrò, C., Simone, D., Siskind, E. J., Spada, F., Spandre, G., Spinelli, P., Strong, A. W., Tajima, H., Thayer, J. B., Torres, D. F., Bloom, E. D., Troja, E., Vandenbroucke, J., Zaharijas, G., Zimmer, S., Fermi-LAT Collaboration, Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Fermi-LAT, Laboratoire Leprince-Ringuet ( LLR ), Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -École polytechnique ( X ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Univers et Particules de Montpellier ( LUPM ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Montpellier 2 - Sciences et Techniques ( UM2 ) -Université de Montpellier ( UM ), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Abdollahi S, Ackermann M, Ajello M, Albert A, Atwood WB, Baldini L, Barbiellini G, Bellazzini R, Bissaldi E, Bloom ED, Bonino R, Bottacini E, Brandt TJ, Bruel P, Buson S, Caragiulo M, Cavazzuti E, Chekhtman A, Ciprini S, Costanza F, Cuoco A, Cutini S, DAmmando F, De Palma F, Desiante R, Digel SW, Di Lalla N, Di Mauro M, Di Venere L, Donaggio B, Drell PS, Favuzzi C, Focke WB, Fukazawa Y, Funk S, Fusco P, Gargano F, Gasparrini D, Giglietto N, Giordano F, Giroletti M, Green D, Guiriec S, Harding AK, Jogler T, Jóhannesson G, Kamae T, Kuss M, Larsson S, Latronico L, Li J, Longo F, Loparco F, Lubrano P, Magill JD, Malyshev D, Manfreda A, Mazziotta MN, Meehan M, Michelson PF, Mitthumsiri W, Mizuno T, Moiseev AA, Monzani ME, Morselli A, Negro M, Nuss E, Ohsugi T, Omodei N, Paneque D, Perkins JS, Pesce-Rollins M, Piron F, Pivato G, Principe G, Rainò S, Rando R, Razzano M, Reimer A, Reimer O, Sgrò C, Simone D, Siskind EJ, Spada F, Spandre G, Spinelli P, Strong AW, Tajima H, Thayer JB, Torres DF, Troja E, Vandenbroucke J, Zaharijas G, Zimmer S, Abdollahi, S, Ackermann, M., Ajello, M., Albert, A., Atwood, W. B., Baldini, L., Barbiellini, G., Bellazzini, R., Bissaldi, E., Bloom, E. D., Bonino, R., Bottacini, E., Brandt, T. J., Bruel, P., Buson, S., Caragiulo, M., Cavazzuti, E., Chekhtman, A., Ciprini, S., Costanza, F., Cuoco, A., Cutini, S., D'Ammando, F., De Palma, F., Desiante, R., Digel, S. W., Di Lalla, N., Di Mauro, M., Di Venere, L., Donaggio, B., Drell, P. S., Favuzzi, C., Focke, W. B., Fukazawa, Y., Funk, S., Fusco, P., Gargano, F., Gasparrini, D., Giglietto, N., Giordano, F., Giroletti, M., Green, D., Guiriec, S., Harding, A. K., Jogler, T., Jóhannesson, G., Kamae, T., Kuss, M., Larsson, S., Latronico, L., Li, J., Longo, Francesco, Loparco, F., Lubrano, P., Magill, J. D., Malyshev, D., Manfreda, A., Mazziotta, M. N., Meehan, M., Michelson, P. F., Mitthumsiri, W., Mizuno, T., Moiseev, A. A., Monzani, M. E., Morselli, A., Negro, M., Nuss, E., Ohsugi, T., Omodei, N., Paneque, D., Perkins, J. S., Pesce Rollins, M., Piron, F., Pivato, G., Principe, G., Rainò, S., Rando, R., Razzano, M., Reimer, A., Reimer, O., Sgrò, C., Simone, D., Siskind, E. J., Spada, F., Spandre, G., Spinelli, P., Strong, A. W., Tajima, H., Thayer, J. B., Torres, D. F., Troja, E., Vandenbroucke, J., Zaharijas, G., and Zimmer, S.

Subjects
[ PHYS.ASTR ] Physics [physics]/Astrophysics [astro-ph], Astrophysics::High Energy Astrophysical Phenomena, General Physics and Astronomy, Cosmic ray, Electrons, Astrophysics, Electron, 7. Clean energy, 01 natural sciences, GLAST, law.invention, Physics and Astronomy, Cosmic rays, Anisotropy, Telescope, Physics and Astronomy (all), Positron, Spitzer Space Telescope, law, 0103 physical sciences, ddc:550, 010303 astronomy & astrophysics, Physics, potential: anisotropy, 010308 nuclear & particles physics, electron: cosmic radiation, Astronomy, Dipole anisotropy, Dipole, anisotropy: dipole, positron, Cosmic-Ray Electron and Positron Anisotropies, Fermi-LAT, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], upper limit, signature, Fermi Gamma-ray Space Telescope
Abstract

Physical review letters 118(9), 091103(2017). doi:10.1103/PhysRevLett.118.091103, The Large Area Telescope on board the Fermi Gamma-ray Space Telescope has collected the largest ever sample of high-energy cosmic-ray electron and positron events since the beginning of its operation. Potential anisotropies in the arrival directions of cosmic-ray electrons or positrons could be a signature of the presence of nearby sources. We use almost seven years of data with energies above 42 GeV processed with the Pass 8 reconstruction. The present data sample can probe dipole anisotropies down to a level of 10$^{−3}$. We take into account systematic effects that could mimic true anisotropies at this level. We present a detailed study of the event selection optimization of the cosmic-ray electrons and positrons to be used for anisotropy searches. Since no significant anisotropies have been detected on any angular scale, we present upper limits on the dipole anisotropy. The present constraints are among the strongest to date probing the presence of nearby young and middle-aged sources., Published by APS, College Park, Md.

Published
2017
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41. Italian Association of Clinical Endocrinologists (AME) and Italian AACE Chapter Position Statement for Clinical Practice: Assessment of Response to Treatment and Follow-Up in Gastroenteropancreatic Neuroendocrine Neoplasms

Author

Grimaldi F., Fazio N., Attanasio R., Frasoldati A., Papini E., Cremonini N., Davi M. V., Funicelli L., Massironi S., Spada F., Toscano V., Versari A., Zini M., Falconi M., Oberg K., Grimaldi, F., Fazio, N., Attanasio, R., Frasoldati, A., Papini, E., Cremonini, N., Davi, M. V., Funicelli, L., Massironi, S., Spada, F., Toscano, V., Versari, A., Zini, M., Falconi, M., and Oberg, K.

Subjects
Markers, NET follow-up, Consensus, Time Factors, Patient Selection, Clinical Decision-Making, Antineoplastic Agents, NEN, Medical Oncology, Imaging, Carcinoma, Neuroendocrine, Decision Support Techniques, Pancreatic Neoplasms, Treatment Outcome, Italy, Carcinoid syndrome, Predictive Value of Tests, Risk Factors, Gastrinoma, Criteria of response, Humans, Insulinoma, Neuroendocrine tumors, Non-functioning NET, Gastrointestinal Neoplasms
Abstract

Well-established criteria for evaluating the response to treatment and the appropriate follow-up of individual patients are critical in clinical oncology. The current evidence-based data on these issues in terms of the management of gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are unfortunately limited. This document by the Italian Association of Clinical Endocrinologists (AME) on the criteria for the follow-up of GEP-NEN patients is aimed at providing comprehensive recommendations for everyday clinical practice based on both the best available evidence and the combined opinion of an interdisciplinary panel of experts. The initial risk stratification of patients with NENs should be performed according to the grading, staging and functional status of the neoplasm and the presence of an inherited syndrome. The evaluation of response to the initial treatment, and to the subsequent therapies for disease progression or recurrence, should be based on a cost-effective, risk-effective and timely use of the appropriate diagnostic resources. A multidisciplinary evaluation of the response to the treatment is strongly recommended and, at every step in the follow-up, it is mandatory to assess the disease state and the patient performance status, comorbidities, and recent clinical evolution. Local expertise, available technical resources and the patient preferences should always be evaluated while planning the individual clinical management of GEP-NENs.

Published
2018

48. Search for gamma-ray emission from the Coma Cluster with six years of Fermi-LAT data

Author

Ackermann, M., Ajello, M., Albert, A., Atwood, W. B., Baldini, L., Ballet, J., Barbiellini, G., Bastieri, D., Bechtol, K., Bellazzini, R., Bissaldi, E., Guiriec, S., Hays, E., Hewitt, J. W., Horan, D., Jóhannesson, G., Kuss, M., Larsson, S., Latronico, L., Li, J., Li, L., Lovellette, M. N., Longo, F., Loparco, F., Lubrano, P., Madejski, G. M., Maldera, S., Manfreda, A., Mayer, M., Mazziotta, M. N., Michelson, P. F., Mitthumsiri, W., Mizuno, T., Moskalenko, I. V., Monzani, M. E., Morselli, A., Murgia, S., Nuss, E., Ohsugi, T., Orienti, M., Orlando, E., Ormes, J. F., Paneque, D., Pesce-Rollins, M., Petrosian, V., Porter, T. A., Piron, F., Pivato, G., Rainò, S., Rando, R., Razzano, M., Reimer, A., Reimer, O., Sánchez-Conde, M., Sgrò, C., Siskind, E. J., Spada, F., Tajima, H., Spandre, G., Spinelli, P., Takahashi, H., Thayer, J. B., Tibaldo, L., Torres, D. F., Tosti, G., Troja, E., Vianello, G., Wood, K. S., Zimmer, S., Blandford, R. D., Fermi-LAT Collaboration, Rephaeli, Y., Bloom, E. D., Bonino, R., Bottacini, E., Bregeon, J., Bruel, P., Buehler, R., Caliandro, G. A., Cameron, R. A., Caragiulo, M., CARAVEO, PATRIZIA, Casandjian, J. M., Cavazzuti, E., Cecchi, C., Charles, E., Chekhtman, A., Chiaro, G., Ciprini, S., Cohen-Tanugi, J., Conrad, J., Cutini, S., D'AMMANDO, FILIPPO, de Angelis, A., de Palma, F., Desiante, R., Digel, S. W., Di Venere, L., Drell, P. S., Favuzzi, C., Fegan, S. J., Fukazawa, Y., Funk, S., Fusco, P., Gargano, F., Gasparrini, D., Giglietto, N., Giordano, F., GIROLETTI, MARCELLO, Godfrey, G., Green, D., Grenier, I. A., Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Fermi-LAT, Ackermann, M., Ajello, M., Albert, A., Atwood, W. B., Baldini, L., Ballet, J., Barbiellini, G., Bastieri, D., Bechtol, K., Bellazzini, R., Bissaldi, E., Blandford, R. D., Bloom, E. D., Bonino, R., Bottacini, E., Bregeon, J., Bruel, P., Buehler, R., Caliandro, G. A., Cameron, R. A., Caragiulo, M., Caraveo, P. A., Casandjian, J. M., Cavazzuti, E., Cecchi, C., Charles, E., Chekhtman, A., Chiaro, G., Ciprini, S., Cohen Tanugi, J., Conrad, J., Cutini, S., D'Ammando, F., De Angelis, A., De Palma, F., Desiante, R., Digel, S. W., Di Venere, L., Drell, P. S., Favuzzi, C., Fegan, S. J., Fukazawa, Y., Funk, S., Fusco, P., Gargano, F., Gasparrini, D., Giglietto, N., Giordano, F., Giroletti, M., Godfrey, G., Green, D., Grenier, I. A., Guiriec, S., Hays, E., Hewitt, J. W., Horan, D., Jóhannesson, G., Kuss, M., Larsson, S., Latronico, L., Li, J., Li, L., Longo, Francesco, Loparco, F., Lovellette, M. N., Lubrano, P., Madejski, G. M., Maldera, S., Manfreda, A., Mayer, M., Mazziotta, M. N., Michelson, P. F., Mitthumsiri, W., Mizuno, T., Monzani, M. E., Morselli, A., Moskalenko, I. V., Murgia, S., Nuss, E., Ohsugi, T., Orienti, M., Orlando, E., Ormes, J. F., Paneque, D., Pesce Rollins, M., Petrosian, V., Piron, F., Pivato, G., Porter, T. A., Rainò, S., Rando, R., Razzano, M., Reimer, A., Reimer, O., Sánchez Conde, M., Sgrò, C., Siskind, E. J., Spada, F., Spandre, G., Spinelli, P., Tajima, H., Takahashi, H., Thayer, J. B., Tibaldo, L., Torres, D. F., Tosti, G., Troja, E., Vianello, G., Wood, K. S., Zimmer, S., Rephaeli, Y., Ackermann M, Ajello M, Albert A, Atwood WB, Baldini L, Ballet J, Barbiellini G, Bastieri D, Bechtol K, Bellazzini R, Bissaldi E, Blandford RD, Blooms ED, Bonino R, Bottacini E, Bregeon J, Bruel P, Buehler R, Caliandro GA, Cameron RA, Caragiulo M, Caraveo PA, Casandjian JM, Cavazzuti E, Cecchi C, Charles E, Chekhtman A, Chiaro G, Ciprini S, Cohen-Tanugi J, Conrad J, Cutini S, DAmmando F, de Angelis A, de Palma F, Desiante R, Digel SW, Di Venere L, Drell PS, Favuzzi C, Fegan SJ, Fukazawa Y, Funk S, Fusco P, Gargano F, Gasparrini D, Giglietto N, Giordano F, Giroletti M, Godfrey G, Green D, Grenier IA, Guiriec S, Hays E, Hewitt JW, Horan D, Johannesson G, Kuss M, Larsson S, Latronico L, Li J, Li L, Longo F, Loparco F, Lovellette MN, Lubrano P, Madejski GM, Maldera S, Manfreda A, Mayer M, Mazziotta MN, Michelson PF, Mitthumsiri W, Mizuno T, Monzani ME, Morselli A, Moskalenko IV, Murgia S, Nuss E, Ohsugi T, Orienti M, Orlando E, Ormes JF, Paneque D, Pesce-Rollins M, Petrosian V, Piron F, Pivato G, Porter TA, Raino S, Rando R, Razzano M, Reimer A, Reimer O, Sanchez-Conde M, Sgro C, Siskind EJ, Spada F, Spandre G, Spinelli P, Tajima H, Takahashi H, Thayer JB, Tibaldo L, Torres DF, Tosti G, Troja E, Vianello G, Wood KS, Zimmer S, Rephaeli Y, Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), ITA, Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
galaxies: clusters: individual, Astrophysics::High Energy Astrophysical Phenomena, clusters: individual (Coma) [galaxies], halo, Cosmic ray, magnetic field, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, gamma rays: galaxies: cluster, 01 natural sciences, Virial theorem, GLAST, Galaxies: clusters: individual (Coma), Space and Planetary Science, Astronomy and Astrophysics, galaxies: clusters: individual (Coma), galaxies: cluster [gamma rays], benchmark, 0103 physical sciences, Coma Cluster, Sensitivity (control systems), structure, gamma ray: flux, cluster, 010303 astronomy & astrophysics, gamma rays: galaxies: clusters, Physics, 010308 nuclear & particles physics, Gamma ray, Radius, electron: secondary, Astronomy and Astrophysic, sensitivity, particle: interaction, gamma ray: emission, Radio halo, field strength, gamma ray: VHE, ddc:520, spectral, galaxy, Astrophysics - High Energy Astrophysical Phenomena, Compton scattering, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Fermi Gamma-ray Space Telescope
Abstract

We present results from {\gamma}-ray observations of the Coma cluster incorporating 6 years of Fermi-LAT data and the newly released {\emph{Pass 8}} event-level analysis. Our analysis of the region reveals low-significance residual structures within the virial radius of the cluster that are too faint for a detailed investigation with the current data. Using a likelihood approach that is free of assumptions on the spectral shape we derive upper limits on the {\gamma}-ray flux that is expected from energetic particle interactions in the cluster. We also consider a benchmark spatial and spectral template motivated by models in which the observed radio halo is mostly emission by secondary electrons. In this case, the median expected and observed upper limits for the flux above 100 MeV are $1.7\times10^{-9}\,\mathrm{ph\,cm^{-2}\,s^{-1}}$ and $5.2\times10^{-9}\,\mathrm{ph\,cm^{-2}\,s^{-1}}$ respectively (the latter corresponds to residual emission at the level of 1.8{\sigma}). These bounds are comparable to or higher than predicted levels of hadronic gamma-ray emission in cosmic-ray models with or without reacceleration of secondary electrons, although direct comparisons are sensitive to assumptions regarding the origin and propagation mode of cosmic rays and magnetic field properties. The minimal expected {\gamma}-ray flux from radio and star-forming galaxies within the Coma cluster is roughly an order of magnitude below the median sensitivity of our analysis., Comment: 9 pages, 4 figures, 2 tables, minor revised version accepted for publication; corresponding authors: S. Zimmer, J. Conrad, O. Reimer & Y. Rephaeli

Published
2016
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49. Search for Spectral Irregularities due to Photon-Axionlike-Particle Oscillations with the Fermi Large Area Telescope

Author

Ajello, M., Albert, A., Anderson, B., Baldini, L., Barbiellini, G., Bastieri, D., Bellazzini, R., Bissaldi, E., Blandford, R. D., Bloom, E. D., Bonino, R., Bottacini, E., Bregeon, J., Bruel, P., Buehler, R., Caliandro, G. A., Cameron, R. A., Caragiulo, M., CARAVEO, PATRIZIA, Cecchi, C., Chekhtman, A., Ciprini, S., Cohen-Tanugi, J., Conrad, J., Costanza, F., D'AMMANDO, FILIPPO, de Angelis, A., de Palma, F., Desiante, R., Di Mauro, M., Di Venere, L., Domínguez, A., Drell, P. S., Favuzzi, C., Focke, W. B., Franckowiak, A., Fukazawa, Y., Funk, S., Fusco, P., Gargano, F., Gasparrini, D., Giglietto, N., Glanzman, T., Godfrey, G., Guiriec, S., Horan, D., Jóhannesson, G., Katsuragawa, M., Kensei, S., Kuss, M., Larsson, S., Latronico, L., Li, J., Li, L., Longo, F., Loparco, F., Lubrano, P., Madejski, G. M., Maldera, S., Manfreda, A., Mayer, M., Mazziotta, M. N., Meyer, M., Michelson, P. F., Mirabal, N., Mizuno, T., Monzani, M. E., Morselli, A., Moskalenko, I. V., Murgia, S., Negro, M., Nuss, E., Okada, C., Orlando, E., Ormes, J. F., Paneque, D., Perkins, J. S., Pesce-Rollins, M., Piron, F., Pivato, G., Porter, T. A., Rainò, S., Rando, R., Razzano, M., Reimer, A., Sánchez-Conde, M., Sgrò, C., Simone, D., Siskind, E. J., Spada, F., Spandre, G., Spinelli, P., Takahashi, H., Thayer, J. B., Torres, D. F., Tosti, G., Troja, E., Uchiyama, Y., Wood, K. S., Wood, M., Zaharijas, G., Zimmer, S., Fermi-LAT Collaboration, ITA, Laboratoire Univers et Particules de Montpellier (LUPM), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Fermi-LAT, Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Ajello M, Albert A, Anderson B, Baldini L, Barbiellini G, Bastieri D, Bellazzini R, Bissaldi E, Blandford RD, Bloom ED, Bonino R, Bottacini E, Bregeon J, Bruel P, Buehler R, Caliandro GA, Cameron RA, Caragiulo M, Caraveo PA, Cecchi C, Chekhtman A, Ciprini S, Cohen-Tanugi J, Conrad J, Costanza F, DAmmando F, de Angelis A, de Palma F, Desiante R, Di Mauro M, Di Venere L, Dominguez A, Drell PS, Favuzzi C, Focke WB, Franckowiak A, Fukazawa Y, Funk S, Fusco P, Gargano F, Gasparrini D, Giglietto N, Glanzman T, Godfrey G, Guiriec S, Horan D, Johannesson G, Katsuragawa M, Kensei S, Kuss M, Larsson S, Latronico L, Li J, Li L, Longo F, Loparco F, Lubrano P, Madejski GM, Maldera S, Manfreda A, Mayer M, Mazziotta MN, Meyer M, Michelson PF, Mirabal N, Mizuno T, Monzani ME, Morselli A, Moskalenko IV, Murgia S, Negro M, Nuss E, Okada C, Orlando E, Ormes JF, Paneque D, Perkins JS, Pesce-Rollins M, Piron F, Pivato G, Porter TA, Raino S, Rando R, Razzano M, Reimer A, Sanchez-Conde M, Sgro C, Simone D, Siskind EJ, Spada F, Spandre G, Spinelli P, Takahashi H, Thayer JB, Torres DF, Tosti G, Troja E, Uchiyama Y, Wood KS, Wood M, Zaharijas G, Zimmer S, Ajello, M., Albert, A., Anderson, B., Baldini, L., Barbiellini, G., Bastieri, D., Bellazzini, R., Bissaldi, E., Blandford, R. D., Bloom, E. D., Bonino, R., Bottacini, E., Bregeon, J., Bruel, P., Buehler, R., Caliandro, G. A., Cameron, R. A., Caragiulo, M., Caraveo, P. A., Cecchi, C., Chekhtman, A., Ciprini, S., Cohen Tanugi, J., Conrad, J., Costanza, F., D'Ammando, F., De Angelis, A., De Palma, F., Desiante, R., Di Mauro, M., Di Venere, L., Domínguez, A., Drell, P. S., Favuzzi, C., Focke, W. B., Franckowiak, A., Fukazawa, Y., Funk, S., Fusco, P., Gargano, F., Gasparrini, D., Giglietto, N., Glanzman, T., Godfrey, G., Guiriec, S., Horan, D., Jóhannesson, G., Katsuragawa, M., Kensei, S., Kuss, M., Larsson, S., Latronico, L., Li, J., Li, L., Longo, Francesco, Loparco, F., Lubrano, P., Madejski, G. M., Maldera, S., Manfreda, A., Mayer, M., Mazziotta, M. N., Meyer, M., Michelson, P. F., Mirabal, N., Mizuno, T., Monzani, M. E., Morselli, A., Moskalenko, I. V., Murgia, S., Negro, M., Nuss, E., Okada, C., Orlando, E., Ormes, J. F., Paneque, D., Perkins, J. S., Pesce Rollins, M., Piron, F., Pivato, G., Porter, T. A., Rainò, S., Rando, R., Razzano, M., Reimer, A., Sánchez Conde, M., Sgrò, C., Simone, D., Siskind, E. J., Spada, F., Spandre, G., Spinelli, P., Takahashi, H., Thayer, J. B., Torres, D. F., Tosti, G., Troja, E., Uchiyama, Y., Wood, K. S., Wood, M., Zaharijas, G., and Zimmer, S.

Subjects
Photon, Opacity, Astrophysics::High Energy Astrophysical Phenomena, Dark matter, General Physics and Astronomy, Astrophysics, Photon–Axionlike-Particle Oscillations, Fermi Large Area Telescope, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, particle: oscillation, GLAST, law.invention, Physics::Geophysics, Telescope, Physics and Astronomy (all), Apparent magnitude, law, 0103 physical sciences, Axion Like Particles, ddc:550, 010306 general physics, cluster, Astrophysics::Galaxy Astrophysics, Physics, Physics and Astronomy, Gamma Ray, 010308 nuclear & particles physics, photon, Gamma ray, Astronomy, opacity, sensitivity, Galaxy, High Energy Physics - Phenomenology, [PHYS.HPHE]Physics [physics]/High Energy Physics - Phenomenology [hep-ph], axion-like particles, spectral, S029IAG, galaxy, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Fermi Gamma-ray Space Telescope
Abstract

Physical review letters 116(16), 161101(2016). doi:10.1103/PhysRevLett.116.161101, e report on the search for spectral irregularities induced by oscillations between photons and axionlike-particles (ALPs) in the γ-ray spectrum of NGC 1275, the central galaxy of the Perseus cluster. Using 6 years of Fermi Large Area Telescope data, we find no evidence for ALPs and exclude couplings above 5×10$^{−12}$ GeV$^{−1}$ for ALP masses 0.5≲m$_a$≲5 neV at 95% confidence. The limits are competitive with the sensitivity of planned laboratory experiments, and, together with other bounds, strongly constrain the possibility that ALPs can reduce the γ-ray opacity of the Universe., Published by APS, College Park, Md.

Published
2016
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50. 2FHL: The Second Catalog of Hard Fermi -LAT Sources

Author

Ackermann, M., Ajello, M., Atwood, W. B., Baldini, L., Ballet, J., Barbiellini, G., Bastieri, D., Becerra, Gonzalez J., Bellazzini, R., Bissaldi, E., Blandford, R. D., Bloom, E. D., Bonino, R., Bottacini, E., Brandt, T. J., Bregeon, J., Bruel, P., Buehler, R., Buson, S., Caliandro, G. A., Cameron, R. A., Caputo, R., Caragiulo, M., Caraveo, P. A., Cavazzuti, E., Cecchi, C., Charles, E., Chekhtman, A., Cheung, C. C., Chiang, J., Chiaro, G., Ciprini, S., Cohen, J. M., Cohen-Tanugi, J., Cominsky, L. R., Conrad, J., Cuoco, A., Cutini, S., D’Ammando, F., de, Angelis A., de, Palma F., Desiante, R., Di, Mauro M., Di, Venere L., Dominn, guez A., Drell, P. S., Favuzzi, C., Fegan, S. J., Ferrara, E. C., Focke, W. B., Fortin, P., Franckowiak, A., Funk, S., Furniss, A. K., Fusco, P., Gargano, F., Gasparrini, D., Giglietto, N., Giommi, P., Giordano, F., Giroletti, M., Glanzman, T., Godfrey, G., Grenier, I. A., Grondin, M.-H., Guillemot, L., Guiriec, S., Harding, A. K., Hays, E., Hewitt, J. W., Hill, A. B., Horan, D., Iafrate, G., Hartmann, Dieter, Jogler, T., Johannesson, G., Johnson, A. S., Knodlseder, J., Kuss, M., La, Mura G., Larsson, S., Latronico, L., Lemoine-Goumard, M., Li, J., Li, L., Longo, F., Loparco, F., Lott, B., Lovellette, M. N., Lubrano, P., Madejski, G. M., Maldera, S., Manfreda, A., Mayer, M., Mazziotta, M. N., Michelson, P. F., Mirabal, N., Mitthumsiri, W., Moiseev, A. A., Monzani, M. E., Morselli, A., Moskalenko, I. V., Murgia, S., Nuss, E., Omodei, N., Orienti, M., Orlando, E., Ormes, J. F., Paneque, D., Perkins, J. S., Pesce-Rollins, M., Petrosian, V., Piron, F., Pivato, G., Porter, T. A., Raino, S., Rando, R., Razzano, M., Razzaque, S., Reimer, A., Reimer, O., Reposeur, T., Romani, R. W., Sanchez-Conde, M., Saz, Parkinson P. M., Schmid, J., Schulz, A., Sgro, C., Siskind, E. J., Spada, F., Spandre, G., Spinelli, P., Suson, D. J., Takahashi, M., Thayer, J. B., Thompson, D. J., Tibaldo, L., Torres, D. F., Tosti, G., Troja, E., Vianello, G., Wood, K. S., Wood, M., Yassine, M., Zaharijas, G., Zimmer, S., Fukazawa, Yasushi, Kamae, Tsuneyoshi, Kataoka, Jun, Mizuno, Tsunefumi, Ohsugi, Takashi, Tajima, Hiroyasu, Takahashi, Hiromitsu, Takahashi, Tadayuki, Stanford University, Santa Cruz Institute for Particle Physics (SCIPP), University of California [Santa Cruz] (UCSC), University of California-University of California, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire Univers et Particules de Montpellier (LUPM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Harvard-Smithsonian Center for Astrophysics (CfA), Smithsonian Institution-Harvard University [Cambridge], Istituto Nazionale di Fisica Nucleare, sezione di Bari (INFN, sezione di Bari), Istituto Nazionale di Fisica Nucleare (INFN), Istituto Nazionale di Astrofisica (INAF), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Unité Scientifique de la Station de Nançay (USN), Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers en région Centre (OSUC), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO), Laboratoire de Physique et Chimie de l'Environnement et de l'Espace (LPC2E), Observatoire des Sciences de l'Univers en région Centre (OSUC), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), GSFC Astrophysics Science Division, NASA Goddard Space Flight Center (GSFC), Istituto Nazionale di Fisica Nucleare, Sezione di Pisa, Hiroshima University, Naval Research Laboratory (NRL), University of California [Santa Cruz] (UC Santa Cruz), University of California (UC)-University of California (UC), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Harvard University-Smithsonian Institution, Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), Stanford University [Stanford], Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Harvard University [Cambridge]-Smithsonian Institution, National Institute for Nuclear Physics (INFN), Université d'Orléans (UO)-Observatoire des Sciences de l'Univers en région Centre (OSUC), PSL Research University (PSL)-PSL Research University (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-Centre National de la Recherche Scientifique (CNRS), PSL Research University (PSL)-PSL Research University (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), GFSC Astrophysics Science Division, Ackermann M, Ajello M, Atwood WB, Baldini L, Ballet J, Barbiellini G, Bastieri D, Gonzalez JB, Bellazzini R, Bissaldi E, Blandford RD, Bloom ED, Bonino R, Bottacini E, Brandt TJ, Bregeon J, Bruel P, Buehler R, Buson S, Caliandro GA, Cameron RA, Caputo R, Caragiulo M, Caraveo PA, Cavazzuti E, Cecchi C, Charles E, Chekhtman A, Cheung CC, Chiang J, Chiaro G, Ciprini S, Cohen JM, Cohen-Tanugi J, Cominsky LR, Conrad J, Cuoco A, Cutini S, DAmmando F, de Angelis A, de Palma F, Desiante R, Di Mauro M, Di Venere L, Dominguez A, Drell PS, Favuzzi C, Fegan SJ, Ferrara EC, Focke WB, Fortin P, Franckowiak A, Fukazawa Y, Funk S, Furniss AK, Fusco P, Gargano F, Gasparrini D, Giglietto N, Giommi P, Giordano F, Giroletti M, Glanzman T, Godfrey G, Grenier IA, Grondin MH, Guillemot L, Guiriec S, Harding AK, Hays E, Hewitt JW, Hill AB, Horan D, Iafrate G, Hartmann D, Jogler T, Johannesson G, Johnson AS, Kamae T, Kataoka J, Knodlseder J, Kuss M, La Mura G, Larsson S, Latronico L, Lemoine-Goumard M, Li J, Li L, Longo F, Loparco F, Lott B, Lovellette MN, Lubrano P, Madejski GM, Maldera S, Manfreda A, Mayer M, Mazziotta MN, Michelson PF, Mirabal N, Mitthumsiri W, Mizuno T, Moiseev AA, Monzani ME, Morselli A, Moskalenko IV, Murgia S, Nuss E, Ohsugi T, Omodei N, Orienti M, Orlando E, Ormes JF, Paneque D, Perkins JS, Pesce-Rollins M, Petrosian V, Piron F, Pivato G, Porter TA, Raino S, Rando R, Razzano M, Razzaque S, Reimer A, Reimer O, Reposeur T, Romani RW, Sanchez-Conde M, Parkinson PMS, Schmid J, Schulz A, Sgro C, Siskind EJ, Spada F, Spandre G, Spinelli P, Suson DJ, Tajima H, Takahashi H, Takahashi M, Takahashi T, Thayer JB, Thompson DJ, Tibaldo L, Torres DF, Tosti G, Troja E, Vianello G, Wood KS, Wood M, Yassine M, Zaharijas G, Zimmer S, Ackermann, M., Ajello, M., Atwood, W. B., Baldini, L., Ballet, J., Barbiellini, G., Bastieri, D., Gonzalez, J. Becerra, Bellazzini, R., Bissaldi, E., Blandford, R. D., Bloom, E. D., Bonino, R., Bottacini, E., Brandt, T. J., Bregeon, J., Bruel, P., Buehler, R., Buson, S., Caliandro, G. A., Cameron, R. A., Caputo, R., Caragiulo, M., Caraveo, P. A., Cavazzuti, E., Cecchi, C., Charles, E., Chekhtman, A., Cheung, C. C., Chiang, J., Chiaro, G., Ciprini, S., Cohen, J. M., Cohen Tanugi, J., Cominsky, L. R., Conrad, J., Cuoco, A., Cutini, S., D'Ammando, F., Angelis, A. De, Palma, F. De, Desiante, R., Mauro, M. Di, Venere, L. Di, Domínguez, A., Drell, P. S., Favuzzi, C., Fegan, S. J., Ferrara, E. C., Focke, W. B., Fortin, P., Franckowiak, A., Fukazawa, Y., Funk, S., Furniss, A. K., Fusco, P., Gargano, F., Gasparrini, D., Giglietto, N., Giommi, P., Giordano, F., Giroletti, M., Glanzman, T., Godfrey, G., Grenier, I. A., Grondin, M. H., Guillemot, L., Guiriec, S., Harding, A. K., Hays, E., Hewitt, J. W., Hill, A. B., Horan, D., Iafrate, G., Hartmann, Dieter, Jogler, T., Jóhannesson, G., Johnson, A. S., Kamae, T., Kataoka, J., Knödlseder, J., Kuss, M., Mura, G. La, Larsson, S., Latronico, L., Lemoine Goumard, M., Li, J., Li, L., Longo, Francesco, Loparco, F., Lott, B., Lovellette, M. N., Lubrano, P., Madejski, G. M., Maldera, S., Manfreda, A., Mayer, M., Mazziotta, M. N., Michelson, P. F., Mirabal, N., Mitthumsiri, W., Mizuno, T., Moiseev, A. A., Monzani, M. E., Morselli, A., Moskalenko, I. V., Murgia, S., Nuss, E., Ohsugi, T., Omodei, N., Orienti, M., Orlando, E., Ormes, J. F., Paneque, D., Perkins, J. S., Pesce Rollins, M., Petrosian, V., Piron, F., Pivato, G., Porter, T. A., Rainò, S., Rando, R., Razzano, M., Razzaque, S., Reimer, A., Reimer, O., Reposeur, T., Romani, R. W., Sánchez Conde, M., Parkinson, P. M. Saz, Schmid, J., Schulz, A., Sgrò, C., Siskind, E. J., Spada, F., Spandre, G., Spinelli, P., Suson, D. J., Tajima, H., Takahashi, H., Takahashi, M., Takahashi, T., Thayer, J. B., Thompson, D. J., Tibaldo, L., Torres, D. F., Tosti, G., Troja, E., Vianello, G., Wood, K. S., Wood, M., Yassine, M., Zaharijas, G., Zimmer, S., and ITA

Subjects
catalog, Active galactic nucleus, Astrophysics::High Energy Astrophysical Phenomena, catalogs, gamma-rays: general, Astrophysics, 01 natural sciences, 7. Clean energy, law.invention, Telescope, law, 0103 physical sciences, Angular resolution, 010303 astronomy & astrophysics, Cherenkov radiation, Space and Planetary Science, Astronomy and Astrophysics, Physics, 010308 nuclear & particles physics, [SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Astronomy, Radius, catalogs – gamma-rays: general, gamma rays: general, Astronomy and Astrophysic, Galaxy, Wavelength, ddc:520, Astrophysics - High Energy Astrophysical Phenomena, Fermi Gamma-ray Space Telescope, general [gamma-rays]
Abstract

著者人数: 154名, Accepted: 2015-10-23, 資料番号: SA1150240000

Published
2016
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