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1. Preclinical validation of human recombinant glutamate-oxaloacetate transaminase for the treatment of acute ischemic stroke

Author

Pérez-Mato, María, Dopico-López, Antonio, Akkoc, Yunus, López-Amoedo, Sonia, Correa-Paz, Clara, Candamo-Lourido, María, Iglesias-Rey, Ramón, López-Arias, Esteban, Bugallo-Casal, Ana, da Silva-Candal, Andrés, Bravo, Susana B., Chantada-Vázquez, María del Pilar, Arias, Susana, Santamaría-Cadavid, María, Estany-Gestal, Ana, Zaghmi, Ahlem, Gauthier, Marc A., Gutiérrez-Fernández, María, Martin, Abraham, Llop, Jordi, Rodríguez, Cristina, Almeida, Ángeles, Migliavacca, Martina, Polo, Ester, Pelaz, Beatriz, Gozuacik, Devrim, El Yamani, Naouale, SenGupta, Tanima, Rundén-Pran, Elise, Vivancos, José, Castellanos, Mar, Díez-Tejedor, Exuperio, Sobrino, Tomás, Rabinkov, Aharon, Mirelman, David, Castillo, José, and Campos, Francisco

Published
2024
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3. A multitrait genetic study of hemostatic factors and hemorrhagic transformation after stroke treatment

Author

Dehghan, Abbas, Heath, Adam S., Morrison, Alanna C., Reiner, Alex P., Johnson, Andrew, Richmond, Anne, Peters, Annette, van Hylckama Vlieg, Astrid, McKnight, Barbara, Psaty, Bruce M., Hayward, Caroline, Ward-Caviness, Cavin, O’Donnell, Christopher, Chasman, Daniel, Strachan, David P., Tregouet, David A., Mook-Kanamori, Dennis, Gill, Dipender, Thibord, Florian, Asselbergs, Folkert W., Leebeek, Frank W.G., Rosendaal, Frits R., Davies, Gail, Homuth, Georg, Temprano, Gerard, Campbell, Harry, Taylor, Herman A., Bressler, Jan, Huffman, Jennifer E., Rotter, Jerome I., Yao, Jie, Wilson, James F., Bis, Joshua C., Hahn, Julie M., Desch, Karl C., Wiggins, Kerri L., Díez-Ahijado, Laia, Raffield, Laura M., Bielak, Lawrence F., Yanek, Lisa R., Kleber, Marcus E., Sabater-Lleal, Maria, Mueller, Martina, Kavousi, Maryam, Mangino, Massimo, Conomos, Matthew P., Liu, Melissa, Brown, Michael R., Jhun, Min-A, Chen, Ming-Huei, de Maat, Moniek P.M., Pankratz, Nathan, Smith, Nicholas L., Peyser, Patricia A., Elliot, Paul, de Vries, Paul S., Wei, Peng, Wild, Philipp S., Morange, Pierre E., van der Harst, Pim, Yang, Qiong, Marioni, Riccardo, Li, Ruifang, Damrauer, Scott M., Cox, Simon R., Trompet, Stella, Felix, Stephan B., Völker, Uwe, Tang, Weihong, Koenig, Wolfgang, Jukema, J. Wouter, Guo, Xiuqing, Gallego-Fabrega, Cristina, Temprano-Sagrera, Gerard, Cárcel-Márquez, Jara, Muiño, Elena, Cullell, Natalia, Lledós, Miquel, Llucià-Carol, Laia, Martin-Campos, Jesús M., Sobrino, Tomás, Castillo, José, Millán, Mònica, Muñoz-Narbona, Lucía, López-Cancio, Elena, Ribó, Marc, Alvarez-Sabin, Jose, Jiménez-Conde, Jordi, Roquer, Jaume, Tur, Silvia, Obach, Victor, Arenillas, Juan F., Segura, Tomas, Serrano-Heras, Gemma, Marti-Fabregas, Joan, Freijo-Guerrero, Marimar, Moniche, Francisco, Castellanos, Maria del Mar, and Fernández-Cadenas, Israel

Published
2024
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8. The systemic impact of non‐surgical treatment of peri‐implantitis with or without adjunctive systemic metronidazole: Secondary analysis of a randomized clinical trial.

Author

Liñares, Antonio, Dopico, Jose, Blanco, Carlota, Pico, Alex, Sobrino, Tomás, Blanco, Juan, and Leira, Yago

Abstract

Objectives: The aim of this study was to evaluate the systemic effect of non‐surgical peri‐implantitis treatment (NSPIT) with or without the administration of systemic metronidazole. Methods: In this secondary analysis from a previously published clinical trial (NCT03564301), peri‐implantitis patients were randomized into two groups: test, receiving NSPIT plus 500 mg of oral systemic metronidazole three times a day for 7 days (n = 10); and control group, receiving NSPIT plus placebo (n = 11). Serum samples were obtained at baseline, 3 and 6 months after therapy to determine levels of inflammatory biomarkers, lipid fractions and complete blood counts. Results: Both treatment modalities produced improvements in clinical and radiographic parameters. After 6 months from NSPIT, a substantial reduction in C‐reactive protein (6.9 mg/dL; 95% CI: 3.7 to 9.9, p <.001) and low‐density lipoprotein cholesterol (21.8 mg/dL; 95% CI: −6.9 to 50.5, p =.013) as well as a modest increase in neutrophils counts (0.4 × 103/μL; 95% CI: −0.4 to 1.1, p =.010) was observed in the control group while the test group showed a significant reduction of TNF‐α (110.1; 95% CI: 38.9 to 181.4, p =.004). Conclusions: NSPIT showed a short‐term beneficial systemic effect regardless of adjunctive use of systemic metronidazole. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Sex-Stratified Genome-Wide Association Study in the Spanish Population Identifies a Novel Locus for Lacunar Stroke.

Author

Cárcel-Márquez, Jara, Muiño, Elena, Gallego-Fabrega, Cristina, Cullell, Natalia, Lledós, Miquel, Llucià-Carol, Laia, Martín-Campos, Jesús M., Sobrino, Tomás, Campos, Francisco, Castillo, José, Freijo, Marimar, Francisco Arenillas, Juan, Obach, Victor, Álvarez-Sabín, José, Molina, Carlos A., Ribó, Marc, Jiménez-Conde, Jordi, Roquer, Jaume, Muñoz-Narbona, Lucia, and Lopez-Cancio, Elena

Published
2024
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13. Small extracellular vesicle-mediated targeting of hypothalamic AMPKα1 corrects obesity through BAT activation

Author

Milbank, Edward, Dragano, Nathalia R. V., González-García, Ismael, Garcia, Marcos Rios, Rivas-Limeres, Verónica, Perdomo, Liliana, Hilairet, Grégory, Ruiz-Pino, Francisco, Mallegol, Patricia, Morgan, Donald A., Iglesias-Rey, Ramón, Contreras, Cristina, Vergori, Luisa, Cuñarro, Juan, Porteiro, Begoña, Gavaldà-Navarro, Aleix, Oelkrug, Rebecca, Vidal, Anxo, Roa, Juan, Sobrino, Tomás, Villarroya, Francesc, Diéguez, Carlos, Nogueiras, Rubén, García-Cáceres, Cristina, Tena-Sempere, Manuel, Mittag, Jens, Carmen Martínez, M., Rahmouni, Kamal, Andriantsitohaina, Ramaroson, and López, Miguel

Published
2021
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15. PSEN2 Mutations May Mimic Frontotemporal Dementia: Two New Case Reports and a Review.

Author

Minguillón Pereiro, Anxo Manuel, Quintáns Castro, Beatriz, Ouro Villasante, Alberto, Aldrey Vázquez, José Manuel, Cortés Hernández, Julia, Aramburu-Núñez, Marta, Arias Gómez, Manuel, Jiménez Martín, Isabel, Sobrino, Tomás, and Pías-Peleteiro, Juan Manuel

Subjects
ALZHEIMER'S disease, FRONTOTEMPORAL dementia, WHITE matter (Nerve tissue), CEREBROSPINAL fluid, GENETIC mutation
Abstract

Background: Monogenic Alzheimer's disease (AD) has severe health and socioeconomic repercussions. Its rarest cause is presenilin 2 (PSEN2) gene mutations. We present two new cases with presumed PSEN2-AD with unusual clinical and neuroimaging findings in order to provide more information on the pathophysiology and semiology of these patients. Methods: Women aged 69 and 62 years at clinical onset, marked by prominent behavioral and language dysfunction, progressing to severe dementia within three years were included. The complete study is depicted. In addition, a systematic review of the PSEN2-AD was performed. Results: Neuroimaging revealed pronounced frontal white matter hyperintensities (WMH) and frontotemporal atrophy/hypometabolism. The genetic study unveiled PSEN2 variants: c.772G>A (p.Ala258Thr) and c.1073-2_1073-1del. Both cerebrospinal fluid (CSF) and experimental blood biomarkers shouldered AD etiology. Conclusions: Prominent behavioral and language dysfunction suggesting frontotemporal dementia (FTD) may be underestimated in the literature as a clinical picture in PSEN2 mutations. Thus, it may be reasonable to include PSEN2 in genetic panels when suspecting FTDL. PSEN2 mutations may cause striking WMH, arguably related to myelin disruption induced by amyloid accumulation. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Random forest-based prediction of stroke outcome

Author

Fernandez-Lozano, Carlos, Hervella, Pablo, Mato-Abad, Virginia, Rodríguez-Yáñez, Manuel, Suárez-Garaboa, Sonia, López-Dequidt, Iria, Estany-Gestal, Ana, Sobrino, Tomás, Campos, Francisco, Castillo, José, Rodríguez-Yáñez, Santiago, and Iglesias-Rey, Ramón

Published
2021
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27. Precision Medicine for Blood Glutamate Grabbing in Ischemic Stroke.

Author

Hervella, Pablo, Sampedro-Viana, Ana, Fernández-Rodicio, Sabela, Rodríguez-Yáñez, Manuel, López-Dequidt, Iria, Pumar, José M., Mosqueira, Antonio J., Bazarra-Barreiros, Marcos, Abengoza-Bello, María Teresa, Ortega-Espina, Sara, Ouro, Alberto, Pérez-Mato, María, Campos, Francisco, Sobrino, Tomás, Castillo, José, Alonso-Alonso, Maria Luz, and Iglesias-Rey, Ramón

Subjects
ISCHEMIC stroke, ASPARTATE aminotransferase, GLUTAMIC acid, INDIVIDUALIZED medicine, TUMOR necrosis factors, PEARSON correlation (Statistics), BLOOD-brain barrier
Abstract

Glutamate grabbers, such as glutamate oxaloacetate transaminase (GOT), have been proposed to prevent excitotoxicity secondary to high glutamate levels in stroke patients. However, the efficacy of blood glutamate grabbing by GOT could be dependent on the extent and severity of the disruption of the blood–brain barrier (BBB). Our purpose was to analyze the relationship between GOT and glutamate concentration with the patient's functional status differentially according to BBB serum markers (soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and leukoaraiosis based on neuroimaging). This retrospective observational study includes 906 ischemic stroke patients. We studied the presence of leukoaraiosis and the serum levels of glutamate, GOT, and sTWEAK in blood samples. Functional outcome was assessed using the modified Rankin Scale (mRS) at 3 months. A significant negative correlation between GOT and glutamate levels at admission was shown in those patients with sTWEAK levels > 2900 pg/mL (Pearson's correlation coefficient: −0.249; p < 0.0001). This correlation was also observed in patients with and without leukoaraiosis (Pearson's correlation coefficients: −0.299; p < 0.001 vs. −0.116; p = 0.024). The logistic regression model confirmed the association of higher levels of GOT with lower odds of poor outcome at 3 months when sTWEAK levels were >2900 pg/mL (OR: 0.41; CI 95%: 0.28–0.68; p < 0.0001) or with leukoaraiosis (OR: 0.75; CI 95%: 0.69–0.82; p < 0.0001). GOT levels are associated with glutamate levels and functional outcomes at 3 months, but only in those patients with leukoaraiosis and elevated sTWEAK levels. Consequently, therapies targeting glutamate grabbing might be more effective in patients with BBB dysfunction. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Systemic biomarker associated with poor outcome after futile reperfusion.

Author

Hervella, Pablo, Sampedro‐Viana, Ana, Rodríguez‐Yáñez, Manuel, López‐Dequidt, Iria, Pumar, José M., Mosqueira, Antonio J., Fernández‐Rodicio, Sabela, Bazarra‐Barreiros, Marcos, Serena, Joaquín, Silva‐Blas, Yolanda, Gubern‐Merida, Carme, Rey‐Aldana, Daniel, Cinza, Sergio, Campos, Francisco, Sobrino, Tomás, Castillo, José, Alonso‐Alonso, Maria Luz, and Iglesias‐Rey, Ramón

Subjects
REPERFUSION, ISCHEMIC stroke, BIOMARKERS, STROKE, RECEIVER operating characteristic curves
Abstract

Background: Successful recanalization does not lead to complete tissue reperfusion in a considerable percentage of ischemic stroke patients. This study aimed to identify biomarkers associated with futile recanalization. Leukoaraiosis predicts poor outcomes of this phenomenon. Soluble tumour necrosis factor‐like weak inducer of apoptosis (sTWEAK), which is associated with leukoaraiosis degrees, could be a potential biomarker. Methods: This study includes two cohorts of ischemic stroke patients in a multicentre retrospective observational study. Effective reperfusion, defined as a reduction of ≥8 points in the National Institutes of Health Stroke Scale (NIHSS) within the first 24 h, was used as a clinical marker of effective reperfusion. Results: In the first cohort study, female sex, age, and high NIHSS at admission (44.7% vs. 81.1%, 71.3 ± 13.7 vs. 81.1 ± 6.7; 16 [13, 21] vs. 23 [17, 28] respectively; p <.0001) were confirmed as predictors of futile recanalization. ROC curve analysis showed that leukocyte levels (sensitivity of 99%, specificity of 55%) and sTWEAK level (sensitivity of 92%, specificity of 88%) can discriminate between poor and good outcomes. Both biomarkers simultaneously are higher associated with outcome after effective reperfusion (OR: 2.17; CI 95% 1.63–4.19; p <.0001) than individually (leukocytes OR: 1.38; CI 95% 1.00–1.64, p =.042; sTWEAK OR: 1.00; C I95% 1.00–1.01, p =.019). These results were validated using a second cohort, where leukocytes and sTWEAK showed a sensitivity of 100% and specificity of 66.7% and 75% respectively. Conclusions: Leukocyte and sTWEAK could be biomarkers of reperfusion failure and subsequent poor outcomes. Further studies will be necessary to explore its role in reperfusion processes. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Differential blood-based biomarkers of subcortical and deep brain small vessel disease.

Author

Hervella, Pablo, Alonso-Alonso, Maria Luz, Sampedro-Viana, Ana, Rodríguez-Yáñez, Manuel, López-Dequidt, Iria, Pumar, José M., Ouro, Alberto, Romaus-Sanjurjo, Daniel, Campos, Francisco, Sobrino, Tomás, Castillo, José, Leira, Yago, and Iglesias-Rey, Ramón

Subjects
CEREBRAL small vessel diseases, LACUNAR stroke, PATHOGENESIS, ALZHEIMER'S disease, BIOMARKERS
Abstract

Background: Cerebral small vessel disease is the most common cause of lacunar strokes (LS). Understanding LS pathogenesis is vital for predicting disease severity, prognosis, and developing therapies. Objectives: To research molecular profiles that differentiate LS in deep brain structures from those in subcortical white matter. Design: Prospective case–control study involving 120 patients with imaging-confirmed LS and a 120 control group. Methods: We examined the relationship between Alzheimer's disease biomarkers [amyloid beta (Aβ1–40, Aβ1–42)], serum inflammatory marker (interleukin-6, IL-6), and endothelial dysfunction markers [soluble tumor necrosis factor-like weak inducer of apoptosis, and pentraxin-3 (sTWEAK, PTX3)] with respect to LS occurring in deep brain structures and subcortical white matter. In addition, we investigated links between LS, leukoaraiosis presence (white matter hyperintensities, WMHs), and functional outcomes at 3 months. Poor outcome was defined as a modified Rankin scale >2 at 3 months. Results: Significant differences were observed in levels of IL-6, PTX3, and sTWEAK between patients with deep lacunar infarcts and those with recent small subcortical infarcts (20.8 versus 15.6 pg/mL, p < 0.001; 7221.3 versus 4624.4 pg/mL, p < 0.0001; 2528.5 versus 1660.5 pg/mL, p = 0.001). Patients with poor outcomes at 3 months displayed notably higher concentrations of these biomarkers compared to those with good outcomes. By contrast, Aβ1–40 and Aβ1–42 were significantly lower in patients with deep LS (p < 0.0001). Aβ1–42 levels were significantly higher in patients with LS in subcortical white matter who had poor outcomes. WMH severity only showed a significant association with deep LS and correlated with sTWEAK (p < 0.0001). Conclusion: The pathophysiological mechanisms of lacunar infarcts in deep brain structures seem different from those in the subcortical white matter. As a result, specific therapeutic and preventive strategies should be explored. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Early Neurological Change After Ischemic Stroke Is Associated With 90-Day Outcome

Author

Heitsch, Laura, Ibanez, Laura, Carrera, Caty, Binkley, Michael M., Strbian, Daniel, Tatlisumak, Turgut, Bustamante, Alejandro, Ribó, Marc, Molina, Carlos, Dávalos, Antoni, López-Cancio, Elena, Muñoz-Narbona, Lucia, Soriano-Tárraga, Carol, Giralt-Steinhauer, Eva, Obach, Victor, Slowik, Agnieszka, Pera, Joanna, Lapicka-Bodzioch, Katarzyna, Derbisz, Justyna, Sobrino, Tomás, Castillo, José, Campos, Francisco, Rodríguez-Castro, Emilio, Arias-Rivas, Susana, Segura, Tomas, Serrano-Heras, Gemma, Vives-Bauza, Cristófol, Díaz-Navarro, Rosa, Tur, Silva, Jimenez, Carmen, Martí-Fàbregas, Joan, Delgado-Mederos, Raquel, Arenillas, Juan, Krupinski, Jerzy, Cullell, Natalia, Torres-Aguila, Nuria P., Muiño, Elena, Cárcel-Márquez, Jara, Moniche, Francisco, Cabezas, Juan A., Ford, Andria L., Dhar, Rajat, Roquer, Jaume, Khatri, Pooja, Jiménez-Conde, Jordi, Fernandez-Cadenas, Israel, Montaner, Joan, Rosand, Jonathan, Cruchaga, Carlos, and Lee, Jin-Moo

Published
2021
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33. Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance

Author

Martínez-Sánchez, Noelia, Seoane-Collazo, Patricia, Contreras, Cristina, Varela, Luis, Villarroya, Joan, Rial-Pensado, Eva, Buqué, Xabier, Aurrekoetxea, Igor, Delgado, Teresa C., Vázquez-Martínez, Rafael, González-García, Ismael, Roa, Juan, Whittle, Andrew J., Gomez-Santos, Beatriz, Velagapudi, Vidya, Tung, Y.C. Loraine, Morgan, Donald A., Voshol, Peter J., Martínez de Morentin, Pablo B., López-González, Tania, Liñares-Pose, Laura, Gonzalez, Francisco, Chatterjee, Krishna, Sobrino, Tomás, Medina-Gómez, Gema, Davis, Roger J., Casals, Núria, Orešič, Matej, Coll, Anthony P., Vidal-Puig, Antonio, Mittag, Jens, Tena-Sempere, Manuel, Malagón, María M., Diéguez, Carlos, Martínez-Chantar, María Luz, Aspichueta, Patricia, Rahmouni, Kamal, Nogueiras, Rubén, Sabio, Guadalupe, Villarroya, Francesc, and López, Miguel

Published
2017
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38. Neuroprotection Afforded by an Enriched Mediterranean-like Diet Is Modified by Exercise in a Rat Male Model of Cerebral Ischemia.

Author

Romaus-Sanjurjo, Daniel, Castañón-Apilánez, María, López-Arias, Esteban, Custodia, Antía, Martin-Martín, Cristina, Ouro, Alberto, López-Cancio, Elena, and Sobrino, Tomás

Subjects
CEREBRAL ischemia, MEDITERRANEAN diet, MALE models, REDUCING diets, ISCHEMIC stroke, DIET, TREADMILL exercise
Abstract

Ischemic stroke is an important cause of mortality and disability worldwide. Given that current treatments do not allow a remarkably better outcome in patients after stroke, it is mandatory to seek new approaches to preventing stroke and/or complementing the current treatments or ameliorating the ischemic insult. Multiple preclinical and clinical studies highlighted the potential beneficial roles of exercise and a Mediterranean diet following a stroke. Here, we investigated the effects of a pre-stroke Mediterranean-like diet supplemented with hydroxytyrosol and with/without physical exercise on male rats undergoing transient middle cerebral artery occlusion (tMCAO). We also assessed a potential synergistic effect with physical exercise. Our findings indicated that the diet reduced infarct and edema volumes, modulated acute immune response by altering cytokine and chemokine levels, decreased oxidative stress, and improved acute functional recovery post-ischemic injury. Interestingly, while physical exercise alone improved certain outcomes compared to control animals, it did not enhance, and in some aspects even impaired, the positive effects of the Mediterranean-like diet in the short term. Overall, these data provide the first preclinical evidence that a preemptive enriched Mediterranean diet modulates cytokines/chemokines levels downwards which eventually has an important role during the acute phase following ischemic damage, likely mediating neuroprotection. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Genome-Wide Association Study of White Blood Cell Counts in Patients With Ischemic Stroke

Author

Torres-Aguila, Nuria P., Carrera, Caty, Giese, Anne-Katrine, Cullell, Natalia, Muiño, Elena, Cárcel-Márquez, Jara, Gallego-Fabrega, Cristina, González-Sánchez, Jonathan, del Mar Freijo, María, Álvarez-Sabín, José, Molina, Carlos, Ribó, Marc, Jimenez-Conde, Jordi, Roquer, Jaume, Sobrino, Tomás, Campos, Francisco, Castillo, José, Muñoz-Narbona, Lucia, Lopez-Cancio, Elena, Dàvalos, Antoni, Diaz-Navarro, Rosa, Tur, Silvia, Vives-Bauza, Cristòfol, Serrano-Heras, Gemma, Segura, Tomás, Krupinski, Jerzy, Delgado-Mederos, Raquel, Martí-Fàbregas, Joan, Heitsch, Laura, Ibañez, Laura, Cruchaga, Carlos, Rost, Natalia S., Montaner, Joan, Lee, Jin-Moo, and Fernandez-Cadenas, Israel

Published
2019
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47. Central nicotine induces browning through hypothalamic κ opioid receptor

Author

Seoane-Collazo, Patricia, Liñares-Pose, Laura, Rial-Pensado, Eva, Romero-Picó, Amparo, Moreno-Navarrete, José María, Martínez-Sánchez, Noelia, Garrido-Gil, Pablo, Iglesias-Rey, Ramón, Morgan, Donald A., Tomasini, Naoki, Malone, Samuel Andrew, Senra, Ana, Folgueira, Cintia, Medina-Gomez, Gema, Sobrino, Tomás, Labandeira-García, José L., Nogueiras, Rubén, Domingos, Ana I., Fernández-Real, José-Manuel, Rahmouni, Kamal, Diéguez, Carlos, and López, Miguel

Published
2019
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49. Association of periodontitis with cognitive decline and its progression: Contribution of blood‐based biomarkers of Alzheimer's disease to this relationship.

Author

Carballo, Álvaro, López‐Dequidt, Iria, Custodia, Antía, Botelho, João, Aramburu‐Núñez, Marta, Machado, Vanessa, Pías‐Peleteiro, Juan Manuel, Ouro, Alberto, Romaus‐Sanjurjo, Daniel, Vázquez‐Vázquez, Laura, Jiménez‐Martín, Isabel, Aguiar, Pablo, Rodríguez‐Yáñez, Manuel, Aldrey, José Manuel, Blanco, Juan, Castillo, José, Sobrino, Tomás, and Leira, Yago

Subjects
DISEASE progression, BIOMARKERS, HYPERTENSION, ALZHEIMER'S disease, CONFIDENCE intervals, PERIODONTITIS, TAU proteins, REGRESSION analysis, AMYLOID beta-protein precursor, NEUROPSYCHOLOGICAL tests, PSYCHOLOGICAL tests, GENE expression, AMBULATORY blood pressure monitoring, DESCRIPTIVE statistics, RESEARCH funding, COGNITION disorders in old age, LOGISTIC regression analysis, SECONDARY analysis, PROPORTIONAL hazards models, DISEASE complications, OLD age
Abstract

Aim: To assess whether periodontitis is associated with cognitive decline and its progression as well as with certain blood‐based markers of Alzheimer's disease. Materials and Methods: Data from a 2‐year follow‐up prospective cohort study (n = 101) was analysed. Participants with a previous history of hypertension and aged ≥60 years were included in the analysis. All of them received a full‐mouth periodontal examination and cognitive function assessments (Addenbrooke's Cognitive Examination (ACE) and Mini‐Mental State Examination [MMSE]). Plasma levels of amyloid beta (Aβ)1‐40, Aβ1‐42, phosphorylated and total Tau (p‐Tau and t‐Tau) were determined at baseline, 12 and 24 months. Results: Periodontitis was associated with poor cognitive performance (MMSE: β = −1.5 [0.6]) and progression of cognitive impairment (hazard ratio [HR] = 1.8; 95% confidence interval: 1.0–3.1). Subjects with periodontitis showed greater baseline levels of p‐Tau (1.6 [0.7] vs. 1.2 [0.2] pg/mL, p <.001) and Aβ1‐40 (242.1 [77.3] vs. 208.2 [73.8] pg/mL, p =.036) compared with those without periodontitis. Concentrations of the latter protein also increased over time only in the periodontitis group (p =.005). Conclusions: Periodontitis is associated with cognitive decline and its progression in elderly patients with a previous history of hypertension. Overexpression of p‐Tau and Aβ1‐40 may play a role in this association. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Prognostic value of blood interleukin-6 in the prediction of functional outcome after stroke: A systematic review and meta-analysis

Author

Bustamante, Alejandro, Sobrino, Tomás, Giralt, Dolors, García-Berrocoso, Teresa, Llombart, Victor, Ugarriza, Iratxe, Espadaler, Marc, Rodríguez, Noelia, Sudlow, Cathie, Castellanos, Mar, Smith, Craig J., Rodríguez-Yánez, Manuel, Waje-Andreassen, Ulrike, Tanne, David, Oto, Jun, Barber, Mark, Worthmann, Hans, Wartenberg, Katja E., Becker, Kyra J., Chakraborty, Baidarbhi, Oh, Seung-Hun, Whiteley, William N., Castillo, José, and Montaner, Joan

Published
2014
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