30 results on '"Smith, Emma Jane"'
Search Results
2. The Diagnostic Accuracy of Cystoscopy for Detecting Bladder Cancer in Adults Presenting with Haematuria: A Systematic Review from the European Association of Urology Guidelines Office
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Devlies, Wout, de Jong, Joep J., Hofmann, Fabian, Bruins, Harman Max, Zuiverloon, Tahlita C.M., Smith, Emma Jane, Yuan, Yuhong, van Rhijn, Bas W.G., Mostafid, Hugh, Santesso, Nancy, Violette, Phil, and Omar, Muhammad Imran
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- 2024
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3. Qualitative and quantitative approaches to modelling tyrosine kinase inhibitor treatment and resistance in non-small cell lung cancer
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Carrick Smith, Emma Jane, Byrne, Helen, Gaffney, Eamonn, and Yates, James
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Drug resistance in cancer cells ,Cancer cells--Growth ,Biology--Mathematical models - Abstract
Non-small cell lung cancer (NSCLC) affects 80-85% of lung cancer patients. Tyrosine kinase inhibitors (TKIs) are targeted therapies that bind to NSCLC cells with specific mutations and inhibit their growth. However, responses to these therapies generally fail due to the emergence of drug resistance and the onset of adverse events which can include; interstitial lung disease (ILD), edema, hypothyroidism, nausea and diarrhoea. Mathematical models can increase our understanding of the biological mechanisms that determine whether a tumour is likely to respond or become resistant to treatment. When combined with experimental studies, such models can provide mechanistic insight into factors which influence the evolution to resistance and how specific drugs act. They can also aid experimental design and generate testable hypotheses concerning, for example, optimal dose regimens, scheduling protocols and combination therapies. In this thesis, we develop mathematical models of tumour growth and treatment response, and use them to determine tumour-specific factors that influence drug resistance. Further, by combining the models with preclinical data, we infer the biological properties of different NSCLC cell lines and characterise their responses to different TKIs. In the first part of the thesis, we develop a mathematical model that describes the dynamics of four cell populations that differ in their levels of resistance to two TKIs. The model accounts for mutations, competition for resources and cellular interactions and is formulated as a system of time-dependent, ordinary differential equations. We use the model to show how tumour responses to TKI combinations depend on the rates at which the tumour cells mutate and proliferate. We then reformulate the model to account for stochastic effects that encapsulate the random nature of mutation events that occur with low probabilities. We find considerable variation in the predictions generated by the deterministic and stochastic modelling frameworks, highlighting the need for careful consideration of the modelling approach when predicting drug resistance and treatment response. The second part of the thesis focuses on integrating mathematical models with experimental data in order to uncover the mechanisms driving NSCLC cells' responses to TKI treatment. We develop a suite of increasingly complex models that describe in vitro cell growth data. We use parameter estimation, information criteria/goodness-of-fit metrics and parameter identifiability analysis to investigate the identifiability of the model parameters given the preclinical data and to guide model selection. We extend the selected model to describe the response of NSCLC cells to TKI treatment. While this model is structurally identifiable, the existence of practically non-identifiable model parameters given the in vitro treatment data leads to uncertainty in the predictions of hidden variables. We use synthetic data to evaluate how experimental design (i.e. what variables are measured) affects certainty in parameter estimates and to generate hypotheses about the likely mechanisms of action of TKIs on NSCLC cells. To summarise, in this thesis, we develop a series of mathematical models that increase our understanding of the biological mechanisms that drive the evolution to resistant tumours and determine tumour response to treatment. Our results highlight the benefit of theoretical approaches for distinguishing the growth dynamics of different NSCLC cell lines, providing mechanistic insight into the effects of different drugs on different cell lines and suggesting strategies for improving experimental design.
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- 2021
4. An exploration of the professional capital of authors who recontextualise knowledge about place in English A level geography textbooks
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Rawlings Smith, Emma-Jane K. C.
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910.71 ,Thesis - Abstract
Initiated in 2014, A level curriculum reform in England was driven by the government's desire to restore academic rigour, help bridge the school-academy divide and better prepare school leavers for the world of work, university and life in society. Reform provided the opportunity to revise A level textbooks and revive their position in the resource ecology of the classroom. Previous research on geography textbooks focuses on textbook perception and use, curriculum coverage and the representation of place. Yet, there is remarkably little research with the author, rather than textbook, as the central concern. My research fills this gap. Textbook authors are an important source of data. Drawing on communities of practice and their own accumulated knowledge and expertise, authors select, organise and transform knowledge created in the parent discipline (its methods, prevailing paradigm and knowledge) and society into a format that is appropriate for use at A level. As the discipline of geography is broad and multi-paradigmatic and the process of recontextualisation is complex, my research focuses on understanding the decisions authors make about place selection and knowledge. Place was selected as it is the most central of geographical concepts and a new core unit for the revised A level subject content. This idiographic case study research elicits the views of nine authors, with data generated using questionnaires, semistructured interviews and Q-sort. The latter is currently an under-used methodology in geography education research. By exploring themes developed through reflexive thematic analysis, findings suggest that authors draw on human, social and decisional capital developed through immersion in teaching, assessment and pedagogy. Furthermore, reflective practice is seen to play a key role in the recontextualisation of knowledge, helping authors to utilise opportunities and deal with constraints experienced during the writing process.
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- 2020
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5. Development of an international glossary for clinical guidelines collaboration
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Christensen, Rachel E., Yi, Michael D., Kang, Bianca Y., Ibrahim, Sarah A., Anvery, Noor, Dirr, McKenzie, Adams, Stephanie, Amer, Yasser S., Bisdorff, Alexandre, Bradfield, Lisa, Brown, Steve, Earley, Amy, Fatheree, Lisa A., Fayoux, Pierre, Getchius, Thomas, Ginex, Pamela, Graham, Amanda, Green, Courtney R., Gresele, Paolo, Hanson, Helen, Haynes, Norrisa, Hegedüs, Laszlo, Hussein, Heba, Jakhmola, Priya, Kantorova, Lucia, Krishnasamy, Rathika, Krist, Alex, Landry, Gregory, Lease, Erika D., Ley, Luis, Marsden, Gemma, Meek, Tim, Meremikwu, Martin, Moga, Carmen, Mokrane, Saphia, Mujoomdar, Amol, Newton, Skye, O'Flynn, Norma, Perkins, Gavin D., Smith, Emma-Jane, Prematunge, Chatura, Rychert, Jenna, Saraco, Mindy, Schünemann, Holger J., Senerth, Emily, Sinclair, Alan, Shwayder, James, Stec, Carla, Tanni, Suzana, Taske, Nichole, Temple-Smolkin, Robyn L., Thomas, Louise, Thomas, Sherene, Tonnessen, Britt, Turner, Amy S., Van Dam, Anne, van Doormaal, Mitchell, Wan, Yung Liang, Ventura, Christina B., McFarlane, Emma, Morgan, Rebecca L., Ogunremi, Toju, and Alam, Murad
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- 2023
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6. Mapping European Association of Urology Guideline Practice Across Europe: An Audit of Androgen Deprivation Therapy Use Before Prostate Cancer Surgery in 6598 Cases in 187 Hospitals Across 31 European Countries
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Heidegger, Isabel, Resch, Johannes Mischinger Irene, Turba, Simon, Zeder, Robin, Lodeta, Braninimir, Van Praet, Charles, Ghysel, Christophe, Arentsen, Harm C., Beysens, Matthias, Vinckier, Marie-Hélène, Mottrie, Alexandre, de Groote, Ruben, Timev, Aleksandar Ivanov, Georgiev, Marincho Ivanov, Yanev, Krassimir Prodanov, Mladenov, Boris, Ivanov, Atanas Slavchev, Antonov, Petar, Valkanov, Stanislav, Tomašković, Igor, Kulis, Tomislav, Bokarica, Pero, Pavlović, Oliver, Krajina, Vinko, Situm, Marijan, Boban, Toni, Soric, Tomislav, Vidic, Ivan, Benko, Goran, Peršec, Zoran, Sović, Tomislav, Zachoval, Roman, Stejskal, Jiri, Capoun, Otakar, Pitra, Tomáš, Gojdič, Marek, Babjuk, Marek, Novák, Vojtěch, Grepl, Michal, Broul, Marek, Novák, Jan, Lund, Lars, Nordström Joensen, Ulla, Borre, Michael, Veskimäe, Priit, Baum, Peep, Tamm, Toomas, Okas, Rauno, Jämsä, Pyry, Lahdensuo, Kanerva, Siltari, Sirkku, Seikkula, Heikki, Palmberg, Christian, Isotalo, Taina, Fiard, Gaelle, Verrier, Cecile, Wiedemann, Laura, Lecornet, Emilie, Leon, Priscilla, Millet, Clementine, Ponzio, Charles, Ploussard, Guillaume, Xylinas, Evanguelos, Ingels, Alexandre, Bigot, Pierre, Le Corre, Vincent, Audenet, François, Berg, Sebastian, Palisaar, Rein-Jueri, Heidenreich, Axel, Seelemeyer, Felix, Krege, Susanne, Leyh-Bannurah, Sami-Ramzi, Witt, Jörn H., Abdirahman, Ayanle, Truß, Michael C., Kranz, Jennifer, Andreas, Karagiannis, Vassileios, Tzortzis, Andreas, Andreou, Paparidis, Spyridon, Davis, Nikolaos Ferakis Niall F., Keane, Kevin G., Fuentes, Adrian, Scuderi, Simone, Barletta, Francesco, Manfredi, Matteo, Porpiglia, Francesco, Cerruto, Maria Angela, Antonelli, Alessandro, Esperto, Francesco, Rossanese, Marta, Veneziano, Domenico, Castelli, Tommaso, Mantica, Roberto La Rocca Marcello Scarcia Guglielmo, Rebuffo, Silvia, Pomara, Giorgio, Pavan, Nicola, Silvestri, Tommaso, Reale, Giulio Francesco, Polara, Andrea, Falagario, Ugo Giovanni, Carrieri, Giuseppe, Ferrari, Giovanni, Brausi, Maurizio, Orecchia, Luca, Annino, Filippo, Kazlauskas, Gražvydas, Stavridis, Sotir, Radovic, Nenad, Vukovic, Marko, van der Slot, Margaretha Adriana, Bruins, Harman Maxim, van Oort, Inge, Witjes, Fred, van der Poel, Henk, Beisland, Christian, Lilleåsenm, Gunder, Müller, Stig, Haug, Erik S., Dimmen, Magne, Czech, Anna K., Nyk, Lukasz, Jaskulski, Jaroslaw, Ratajczyk, Krzysztof, Azevedo, Nuno, Braga, Isaac, Pereira, João, Lúcio, Rui, Pina, João, da Silva, Edgar Miguel Calvo Loureiro Tavares, Furriel, Frederico, Mota, Paulo, Rodrigues, Miguel, Radavoi, George Daniel, Crisan, Nicolae, Andras, Iulia, Robert, Stoica, Bratu, Ovidiu, Surcel, Cristian, Kotov, Sergei, Malkhasyan, Vigen, Petrov, Sergei, Reva, Sergei, Bumbasirevic, Uros, Kováčik, Viktor, Perečinský, Ivan, Rybár, Ľuboš, Šulgan, Ján, Briš, Lukáš, Jursová, Katarína, Chovan, Miroslav, Kička, Tomáš, Taskovska, Milena, Kovačič, Rok, Miklavžina, Andraž, Alvarez-Maestro, Mario, De Castro, Javier Mayor, Aragón-Chamizo, Juan, Sutil, Raquel Sopeña, Perrello, Carmen Garau, Vilaseca, Antoni, Perez, Jorge Huguet, Ovide, Julia Aumatell, Planas, Jacques, Borque-Fernando, Angel, Sánchez-Izquierdo, Elena, Jimenez, Jose Luis Marenco, Lendínez-Cano, Guillermo, Puche-Sanz, Ignacio, Garcia-Baquero, Rodrigo, Esteban, Mario Domínguez, Pérez-Fentes, Daniel, Serván, Patricia Parra, Koskela, Lotta Renström, Stranne, Johan, Scholtz, Bianca, Torbrand, Christian, Wagenius, Magnus, Ugge, Henrik, Örtegren, Joakim, Langenauer, Janine, Zumstein, Valentin, Schmid, Hans Peter, Rieken, Malte, Saba, Karim, Strebel, Raeto T., Mortezavi, Ashkan, Rentsch, Cyrill, Roth, Beat, Eberli, Daniel, Pascal, Oechslin, Auer, Rebecca, John, Hubert, Thalmann, George N., Baltacı, Sümer, Mungan, Aydın, Sözen, Sinan, Cetin, Serhat, Aslan, Guven, Türkeri, Levent, İzol, Volkan, Demirdağ, Çetin, Ozden, Sami Berk, Toktaş, Gökhan, Sarikaya, Şaban, Tinay, İlker, Müezzinoğlu, Talha, Erbatu, Oguzcan, Sagnak, Levent, Akdoğan, Bülent, Can, Cavit, Şahin, Hayrettin, Yazıcı, Cenk Murat, Volkov, Serhii, Shulyak, Olexandr, Douglas, David, Hemmant, Joshua, El-Taji, Omar, Ahmad, Imran, Nalagatla, Sarika, Janebdar, Husay, Veeratterapillay, Rajan, Rai, Bhavan, Conroy, Samantha, Cumberbatch, Marcus, Malde, Sachin, MacLennan, Steven, Duncan, Eilidh, Dunsmore, Jennifer, Fullwood, Louise, Lumen, Nicolaas, Plass, Karin, Ribal, Maria J., Roobol, Monique J., Nieboer, Daan, Schouten, Natasha, Skolarus, Ted A., Smith, Emma Jane, N'Dow, James, Mottet, Nicolas, and Briganti, Alberto
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- 2023
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7. Improving Guideline Adherence in Urology
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MacLennan, Steven, Duncan, Eilidh, Skolarus, Ted A., Roobol, Monique J., Kasivisvanathan, Veeru, Gallagher, Kevin, Gandaglia, Giorgio, Sakalis, Vasileios, Smith, Emma Jane, Plass, Karin, Ribal, Maria J., N'Dow, James, and Briganti, Alberto
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- 2022
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8. The Key Role of Patient Involvement in the Development of Core Outcome Sets in Prostate Cancer
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Smith, Emma Jane, N'Dow, James, Plass, Karin, Ribal, Maria, Mottet, Nicolas, Shepherd, Robert, Moris, Lisa, Lardas, Michael, Van den Broeck, Thomas, Willemse, Peter-Paul, Campi, Riccardo, Gacci, Mauro, Bjartell, Anders, Evans-Axelsson, LU Susan, Briganti, Alberto, Gandaglia, Giorgio, Crosti, Daniele, Meoni, Massimiliano, Garzonio, Roberto, Bangma, Chris, Roobol, Monique, Remmers, Sebastiaan, Tilki, Derya, Auvinen, Anssi, Murtola, Teemu, Visakorpi, Tapio, Talala, Kirsi, Tammela, Teuvo, Siltari, Aino, Van Hemelrijck, Mieke, Beyer, Katharina, Lejeune, Stephane, van Diggelen, Femke, Byrne, Sophie, Fialho, Luz, Cardone, Antonella, Gono, Paulina, De Meulder, Bertrand, Auffray, Charles, Balaur, Irina-Afrodita, Taibi, Nesrine, Power, Shaun, Kermani, Nazanin Zounemat, van Bochove, Kees, Cirillo, Elisa, Moinat, Maxim, Voss, Emma, Horgan, Denis, Fullwood, Louise, Holtorf, Marc, Lancet, Doron, Bernstein, Gabi, Omar, Imran, MacLennan, Sara, MacLennan, Steven, Tripathee, Sheela, Huber, Johannes, Wirth, Manfred, Froehner, Michael, Brenner, Beate, Borkowetz, Angelika, Thomas, Christian, Horn, Friedemann, Reiche, Kristin, Kreuz, Markus, Josefsson, Andreas, Tandefelt, Delila Gasi, Hugosson, Jonas, Schalken, Jack, Huisman, Henkjan, Hofmarcher, Thomas, Lindgren, Peter, Andersson, Emelie, Fridhammar, Adam, Asiimwe, Alex, Verholen, Frank, Zong, Jihong, Butler-Ransohoff, John-Edward, Williamson, Todd, Chandrawansa, Kumari, Waldeck, Reg, Molnar, Megan, Bruno, Amanda, Herrera, Ronald, Nevedomskaya, Ekaterina, Fatoba, Samuel, Constantinovici, Niculae, Mohamed, Ateesha, Steinbeißer, Carl, Kedhagae, Siddhanth, Maass, Monika, Torremante, Patrizia, Voss, Marc Dietrich, Devecseri, Zsuzsanna, Abbott, Tom, Kiran, Amit, Dau, Chad, Papineni, Kishore, Wang-silvanto, Jing, Hass, Steve, Snijder, Robert, Doyé, Verena, Wang, Xuewei, Garnham, Andy, Lambrecht, Mark, Wolfinger, Russ, Rogiers, Stijn, Servan, Angela, Casariego, Joaquin, Samir, Mohamed, Pascoe, Katie, Robinson, Paul, Reich, Christian, Ratwani, Shilpa, Longden-Chapman, Elaine, Burke, Danny, Agapow, Paul, Derkits, Sahra, Licour, Muriel, Ang, Michelle, Payne, Sarah, Yong, Alan, Thompson, Lucy, Le Mare, Sophia, Bussmann, Michael, Köhler, Inken, Juckeland, Guido, Kotik, Daniel, MacLennan, Sara J., Mastris, Ken, Hooker, Gary, Greene, Robert, Briers, Erik, Omar, Muhammad Imran, Healey, Jemma, Venderbos, Lionne D.F., Smith, Emma J., Bjorkqvist, Josefine, Roobol, Monique J., and N’Dow, James
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- 2021
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9. Trends in incidence, prevalence, and survival of breast cancer in the United Kingdom from 2000 to 2021.
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Barclay, Nicola L., Burn, Edward, Delmestri, Antonella, Duarte-Salles, Talita, Golozar, Asieh, Man, Wai Yi, Tan, Eng Hooi, Tietzova, Ilona, N'Dow, James, Witjes, Wim, Smith, Emma Jane, Bezuidenhout, Carla, Collen, Sarah, Plass, Karin, Blum, Torsten Gerriet, Borkowetz, Angelika, Willemse, Peter-Paul, Cornford, Philip, Dabestani, Saeed, and Schlief, Maurice
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BREAST cancer ,MALE breast cancer ,YOUNG women ,OVERALL survival ,SURVIVAL rate - Abstract
Breast cancer is the most frequently diagnosed cancer in females globally. However, we know relatively little about trends in males. This study describes United Kingdom (UK) secular trends in breast cancer from 2000 to 2021 for both sexes. We describe a population-based cohort study using UK primary care Clinical Practice Research Datalink (CPRD) GOLD and Aurum databases. There were 5,848,436 eligible females and 5,539,681 males aged 18+ years, with ≥ one year of prior data availability in the study period. We estimated crude breast cancer incidence rates (IR), prevalence and survival probability at one-, five- and 10-years after diagnosis using the Kaplan–Meier method. Analyses were further stratified by age. Crude IR of breast cancer from 2000 to 2021 was 194.4 per 100,000 person-years for females and 1.16 for males. Crude prevalence in 2021 was 2.1% for females and 0.009% for males. Both sexes have seen around a 2.5-fold increase in prevalence across time. Incidence increased with age for both sexes, peaking in females aged 60–69 years and males 90+. There was a drop in incidence for females aged 70–79 years. From 2003–2019, incidence increased > twofold in younger females (aged 18–29: IR 2.12 in 2003 vs. 4.58 in 2018); decreased in females aged 50–69 years; and further declined from 2015 onwards in females aged 70–89 years. Survival probability for females after one-, five-, and ten-years after diagnosis was 95.1%, 80.2%, and 68.4%, and for males 92.9%, 69.0%, and 51.3%. Survival probability at one-year increased by 2.08% points, and survival at five years increased by 5.39% from 2000–2004 to 2015–2019 for females, particularly those aged 50–70 years. For males, there were no clear time-trends for short-term and long-term survival probability. Changes in incidence of breast cancer in females largely reflect the success of screening programmes, as rates rise and fall in synchronicity with ages of eligibility for such programmes. Overall survival from breast cancer for females has improved from 2000 to 2021, again reflecting the success of screening programmes, early diagnosis, and improvements in treatments. Male breast cancer patients have worse survival outcomes compared to females, highlighting the need to develop male-specific diagnosis and treatment strategies to improve long-term survival in line with females. [ABSTRACT FROM AUTHOR]
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- 2024
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10. Fighting the invisible enemy : being a parent of a child who has been given a diagnosis of Pervasive Refusal Syndrome
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Smith, Emma Jane
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150 - Abstract
Pervasive Refusal Syndrome was introduced to the child and adolescent psychiatric literature by Lask, Britten, Kroll, Magagna and Tranter in 1991. It is not a formal diagnosis classified within the DSM-V (APA, 2013) or ICD-10 (WHO, 1994). However, it is employed clinically as a descriptive label to denote a specific constellation of symptoms. It is understood to be characterised by a profound and pervasive refusal across different domains: eating, drinking, speech, mobilisation, and personal care (Lask et al., 1991). It is reported to be accompanied with an active rejection of help, social withdrawal and school refusal (Lask et al., 1991; Thompson & Nunn, 1997). A literature review highlighted that perspectives on PRS are predominantly based on expert professional opinion; the experiences and perspectives of children and their families are underrepresented. This exploratory study aimed to address this gap in the literature by examining how parents made sense of their child being given a diagnosis of PRS and what it was like to experience their child being unwell. Furthermore it aimed to explore how parents experienced and negotiated the treatment process. Semi-structured interviews were conducted with eight participants. The data generated from the interviews was analysed using Interpretative Phenomenological Analysis. Three superordinate themes were identified and represented: parents’ perspectives and experiences of PRS and its treatment; parents’ experiences of and relationships with professionals; and the personal “journey” that parents experienced. The findings suggested that parents’ experiences and meaning making processes were delineated by stages, which reflected the trajectory of their child’s difficulties. It seemed each stage brought new experiences, understandings and challenges. This study has provided a novel contribution to the literature and has offered new insights into the diagnosis from the perspective of a parent. The implications for clinical practice and recommendations for future research are outlined.
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- 2015
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11. Critical care admission following elective surgery was not associated with survival benefit: prospective analysis of data from 27 countries
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Kahan, Brennan C., Koulenti, Desponia, Arvaniti, Kostoula, Beavis, Vanessa, Campbell, Douglas, Chan, Matthew, Moreno, Rui, Pearse, Rupert M., Pearse, Rupert M., Beattie, Scott, Clavien, Pierre-Alain, Demartines, Nicolas, Fleisher, Lee A., Grocott, Mike, Haddow, James, Hoeft, Andreas, Holt, Peter, Moreno, Rui, Pritchard, Naomi, Rhodes, Andrew, Wijeysundera, Duminda, Wilson, Matt, Ahmed, Tahania, Everingham, Kirsty, Hewson, Russell, Januszewska, Marta, Pearse, Rupert M., Phull, Mandeep-Kaur, Halliwell, Richard, Shulman, Mark, Myles, Paul, Schmid, Werner, Hiesmayr, Michael, Wouters, Patrick, de Hert, Stefan, Lobo, Suzana, Beattie, Scott, Wijeysundera, Duminda, Fang, Xiangming, Rasmussen, Lars, Futier, Emmanuel, Biais, Matthieu, Venara, Aurélien, Slim, Karem, Sander, Michael, Koulenti, Despoina, Arvaniti, Kostoula, Chan, Mathew, Kulkarni, Atul, Chandra, Susilo, Tantri, Aida, Geddoa, Emad, Abbas, Muntadhar, Della Rocca, Giorgio, Sivasakthi, Datin, Mansor, Marzida, Luna, Pastor, Bouwman, Arthur, Buhre, Wolfgang, Beavis, Vanessa, Campbell, Douglas, Short, Tim, Osinaike, Tunde, Matos, Ricardo, Grigoras, Ioana, Kirov, Mikhail, Protsenko, Denis, Biccard, Bruce, Aldecoa, Cesar, Chew, Michelle, Hofer, Christoph, Hubner, Martin, Ditai, James, Szakmany, Tamas, Fleisher, Lee, Ferguson, Marissa, MacMahon, Michael, Shulman, Mark, Cherian, Ritchie, Currow, Helen, Kanathiban, Kathirgamanathan, Gillespie, David, Pathmanathan, Edward, Phillips, Katherine, Reynolds, Jenifer, Rowley, Joanne, Douglas, Jeanene, Kerridge, Ross, Currow, Helen, Garg, Sameer, Bennett, Michael, Jain, Megha, Alcock, David, Terblanche, Nico, Cotter, Rochelle, Leslie, Kate, Stewart, Marcelle, Zingerle, Nicolette, Clyde, Antony, Hambidge, Oliver, Rehak, Adam, Cotterell, Sharon, Binh QuanHuynh, Wilson, McCulloch, Timothy, Ben-Menachem, Erez, Egan, Thomas, Cope, Jennifer, Halliwell, Richard, Fellinger, Paul, Haselberger, Simone, Holaubek, Caroline, Lichtenegger, Paul, Scherz, Florian, Schmid, Werner, Hoffer, Franz, Cakova, Veronika, Eichwalder, Andreas, Fischbach, Norbert, Klug, Reinhold, Schneider, Elisabeth, Vesely, Martin, Wickenhauser, Reinhart, Grubmueller, Karl Gernot, Leitgeb, Marion, Lang, Friedrich, Toro, Nancy, Bauer, Marlene, Laengle, Friedrich, Mayrhofer, Thomas, Buerkle, Christian, Forstner, Karin, Germann, Reinhard, Rinoesl, Harald, Schindler, Elke, Trampitsch, Ernst, Fritsch, Gerhard, Szabo, Christian, Bidgoli, Jawad, Verdoodt, Hans, Forget, Patrice, Kahn, David, Lois, Fernande, Momeni, Mona, Prégardien, Caroline, Pospiech, Audrey, Steyaert, Arnaud, Veevaete, Laurent, De Kegel, Dirk, De Jongh, Karen, Foubert, Luc, Smitz, Carine, Vercauteren, Marcel, Poelaert, Jan, Van Mossevelde, Veerle, Abeloos, Jacques, Bouchez, Stefaan, Coppens, Marc, De Baerdemaeker, Luc, Deblaere, Isabel, De Bruyne, Ann, De Hert, Stefan, Fonck, Kristine, Heyse, Bjorn, Jacobs, Tom, Lapage, Koen, Moerman, Anneliese, Neckebroek, Martine, Parashchanka, Aliaksandra, Roels, Nathalie, Van Den Eynde, Nancy, Vandenheuvel, Michael, Van Limmen, Jurgen, Vanluchene, Ann, Vanpeteghem, Caroline, Wouters, Patrick, Wyffels, Piet, Huygens, Christel, Vandenbempt, Punitha, Van de Velde, Marc, Dylst, Dimitri, Janssen, Bruno, Schreurs, Evelien, Aleixo, Fábia Berganton, Candido, Keulle, Dias Batista, Hugo, Guimarães, Mario, Guizeline, Jaqueline, Hoffmann, João, Lobo, Suzana M., Lobo, Francisco Ricardo, Nascimento, Vinícius, Nishiyama, Katia, Pazetto, Lucas, Souza, Daniela, Souza Rodrigues, Rodrigo, Vilela dos Santos, Ana Maria, Jardim, Jaquelline, Silva, Joao, do NascimentoJunior, Paulo, Baio, Thalissa Hermínia, Pereira de Castro, Gabriel Isaac, Watanabe Oliveira, Henri Roger, Amendola, Cristina Prata, Cardoso, Gutemberg, Ortega, Daniela, Brotto, Ana Flavia, De Oliveira, Mirella Cristine, Réa-Neto, Álvaro, Dias, Fernando, Azambuja, Pedro, Knibel, Marcos Freitas, Martins, Antonio, Almeida, William, Neto, Calim Neder, Tardelli, Maria Angela, Caser, Eliana, Machado, Marcio, Aguzzoli, Crisitiano, Baldisserotto, Sérgio, Beck Tabajara, Fernanda, Bettega, Fernanda, Rodrigues Júnior, La Hore Correa, de Gasperi, Julia, Faina, Lais, Nolasco, Marcos Farias, da Costa Fischer, Bruna Ferreira, de Campos Ferreira, Mariana Fosch, Hartmann, Cristina, Kliemann, Marta, Ribeiro, Gustavo LuisHubert, Fraga, Julia Merladete, Netto, Thiago Motta, Pozza, Laura Valduga, Wendling, Paulo Rafael, Azevedo, Caroline, Garcia, Juliana, Lopes, Marcel, Maia, Bernardo, Maselli, Paula, Melo, Ralph, Mendes, Weslley, Neves, Matheus, Ney, Jacqueline, Piras, Claudio, Applewhaite, Christopher, Carr, Adrienne, Chow, Lorraine, Duttchen, Kaylene, Foglia, Julena, Greene, Michael, Hinther, Ashley, Houston, Kendra, McCormick, Thomas Jared, Mikhayel, Jennifer, Montasser, Sam, Ragan, Alex, Suen, Andrew, Woolsey, Adrianna, Yu, Hai Chuan, Funk, Duane, Kowalski, Stephen, Legaspi, Regina, McDonald, Heather, Siddiqui, Faisal, Pridham, Jeremy, Rowe, Bernadette, Sampson, Sonia, Thiessen, Barton, Zbitnew, Geoff, Bernard, Andre, George, Ronald, Jones, Philip, Moor, Rita, Siddiqui, Naveed, Wolfer, Alexandra, Tran, Diem, Winch, Denyse, Dobson, Gary, Hinther, Ashley, McCormick, Thomas, Montasser, Osama, Suen, Andrew, Woolsey, Adrianna, Bernard, Andre, George, Ronald, Hall, Richard, Bernard, Andre, George, Ronald, Hall, Richard, Applewhaite, Christopher, Baghirzada, Leyla, McCormick, Thomas Jared, Suen, Andrew, Dai, Si Yuan, Hare, Gregory, Lee, Esther, Shastri, Uma, Tsui, Albert, Yagnik, Anmol, Alvares, Danielle, Choi, Stephen, Dwyer, Heather, Flores, Kathrina, McCartney, Colin, Somascanthan, Priya, Beattie, Scott, Carroll, Jo, Pazmino-Canizares, Janneth, Wijeysundera, Duminda, Wolfer, Alexandra, Ami, Noam, Chan, Vincent, Perlas, Anahi, Argue, Ruth, Lavis, Katie, Mayson, Kelly, Cao, Ying, Gao, Hong, hu, tingju, Lv, Jie, Yang, Jian, Yang, Yang, Zhong, Yi, Zhou, Jing, Zou, Xiaohua, He, Miao, Li, Xiaoying, Luo, Dihuan, Wang, Haiying, Yu, Tian, Chen, Liyong, Wang, Lijun, Cai, Yunfei, Cao, Zhongming, Li, Yanling, Lian, 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Ikemefuna, Onuora, Elias, Onyeka, Tonia, Ugwu, Innocent, Umeh, Friday, Alagbe-Briggs, Olubusola, Dodiyi-Manuel, Amabra, Echem, Richard, Obasuyi, Bright, Onajin-Obembe, Bisola, Bandeira, Maria Expedito, Martins, Alda, Tomé, Miguel, Martins Costa, Ana Cristina Miranda, Krystopchuk, Andriy, Branco, Teresa, Esteves, Simao, Melo, Marco António, Monte, Júlia, Rua, Fernando, Martins, Isabel, Pinho-Oliveira, Vítor Miguel, Rodrigues, Carla Maria, Cabral, Raquel, Marques, Sofia, Rêgo, Sara, Teixeira Jesus, Joana Sofia, Conceição Marques, Maria, Romao, Cristina, Dias, Sandra, Santos, Ana Margarida, Alves, Maria Joao, Salta, Cristina, Cruz, Salome, Duarte, Célia, Furtado Paiva, António Armando, do Nascimento Cabral, Tiago, Fariae Maia, Dionisio, Correia da Silva, Rui Freitas Mendonça, Langner, Anuschka, Oliveira Resendes, Hernâni, da Conceição Soares, Maria, Abrunhosa, Alexandra, Faria, Filomena, Miranda, Lina, Pereira, Helena, Serra, Sofia, Ionescu, Daniela, Margarit, Simona, Mitre, Calin, Vasian, Horatiu, Manga, Gratiela, Stefan, Andreea, Tomescu, Dana, Filipescu, Daniela, Paunescu, Marilena-Alina, Stefan, Mihai, Stoica, Radu, Gavril, Laura, Pătrăşcanu, Emilia, Ristescu, Irina, Rusu, Daniel, Diaconescu, Ciresica, Iosep, Gabriel Florin, Pulbere, Dorin, Ursu, Irina, Balanescu, Andreea, Grintescu, Ioana, Mirea, Liliana, Rentea, Irina, Vartic, Mihaela, Lupu, Mary-Nicoleta, Stanescu, Dorin, Streanga, Lavinea, Antal, Oana, Hagau, Natalia, Patras, Dumitru, Petrisor, Cristina, Tosa, Flaviu, Tranca, Sebastian, Copotoiu, Sanda Maria, Ungureanu, Liviu Lucian, Harsan, Cristian Remus, Papurica, Marius, Cernea, Daniela Denisa, Dragoescu, Nicoleta Alice, Aflori, Laura, Vaida, Carmen, Ciobotaru, Oana Roxana, Aignatoaie, Mariana, Carp, Cristina Paula, Cobzaru, Isabelle, Mardare, Oana, Purcarin, Bianca, Tutunaru, Valentin, Ionita, Victor, Arustei, Mirela, Codita, Anisoara, Busuioc, Mihai, Chilinciuc, Ion, Ciobanu, Cristina, Belciu, Ioana, Tincu, Eugen, Blaj, Mihaela, Grosu, 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Bunwarie, Bimalshakth, Hernandez, Carlos B., Jeeraz, Mohammud A., Legutko, Dagmara A., Lopez, Acela G., De Meyer, Jenine N., Muzenda, Tanaka, Naidoo, Noel, Patel, Maryam, Pentela, Rao, Junge, Marina, Mansoor, Naj, Rademan, Lana, Scislowski, Pawel, Seedat, Ismail, van den Berg, Bianca, van der Merwe, Doreen, van Wyk, Steyn, Govender, Komalan, Naicker, Darshan, Ramjee, Rajesh, Saley, Mueen, Kuhn, Warren Paul, Matos-Puig, Roel, Moolla, Zaheer, Lisi, Alberto, Perez, Gisela, Valle Beltran, Anna, Lozano, Angels, Delgado Navarro, Carlos, Duca, Alejandro, Pastor Martinez, Ernesto, Ferrando, Carlos, Fuentes, Isabel, García-Pérez, Maria Luisa, Gracia, Estefania, Izquierdo Palomares, Ana, Katime, Antonio, Miñana, Amanda, Incertis, Raul, Romero, Esther, Romero Garcia, Carolina Soledad, Rubio, Concepcion, Socorro Artiles, Tania, Soro, Marina, Valls, Paola, Laguarda, Gisela Alaman, Benavent, Pau, Cuenca, Vicente Chisbert, Cueva, Andreu, Lafuente, Matilde, Parra, Asuncion Marques, Rodrigo, Alejandra 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Francisco, Gondo, Prisca, Hadebe, Bernard, Onie Hove, Mazvangu, khader, Ahamed, Krishnachetty, Bobby, Rhodes, Karen, Sokhi, Jagdish, Baker, Katie-Anne, Bertram, Wendy, Looseley, Alex, Mouton, Ronelle, Arnold, Glenn, Arya, Shobhit, Balfoussia, Danai, Baxter, Linden, Harris, James, Jones, Craig, Knaggs, Alison, Markar, Sheraz, Perera, Anisha, Scott, Alasdair, Shida, Asako, Sirha, Ravneet, Wright, Sally, Frost, Victoria, Gray, Catherine, MacGregor, Mark, Andrews, Emma, Arrandale, Lindsay, Barrett, Stephen, Bidd, Heena, Cifra, Elna, Cooper, Mariese, Dragnea, Dragos, Elna, Cifra, Maclean, Jennifer, Meier, Sonja, Milliken, Donald, Munns, Christopher, Ratanshi, Nadir, Salvana, Abegail, Watson, Anthony, Ali, Hani, Campbell, Gill, Critchley, Rebecca, Hicks, Catherine, Liddle, Alison, Pass, Marc, Ritchie, Charlotte, Thomas, Charlotte, Too, Lingxi, Welsh, Sarah, Gill, Talvinder, Johnson, Joanne, Reed, Joanne, Davis, Edward, Papadopoullos, Sam, Attwood, Clare, Biffen, Andrew, Boulton, Kerenza, Gray, Sophie, Hay, David, Mills, Sarah, Montgomery, Jane, Riddell, Rory, Simpson, James, Bhardwaj, Neeraj, Paul, Elaine, Uwubamwen, Nosakhare, Vohra, Akbar, Berntsen, Emer, Nolan, Tracey, Turner, Angus, Alexander, Maini, Arrich, James, Arumugam, Swarna, Blackwood, Douglas, Boggiano, Victoria, Brown, Robyn, Lam Chan, Yik, Chatterjee, Devnandan, Chhabra, Ashok, Christian, Rachel, Costelloe, Hannah, CoxwellMatthewman, Madeline, Dalton, Emma, Darko, Julia, Davari, Maria, Dave, Tejal, Deacon, Matthew, Deepak, Shantal, Edmond, Holly, Ellis, Jessica, El-Sayed, Ahmed, Eneje, Philip, English, Rose, Ewe, Renee, Foers, William, Franklin, John, Gallego, Laura, Garrett, Emily, Goldberg, Olivia, Goss, Harry, Greaves, Rosanna, Harris, Rudy, Hennings, Charles, Jones, Eleanor, Kamali, Nelson, Kokkinos, Naomi, Lewis, Carys, Lignos, Leda, Malgapo, Evaleen Victoria, Malik, Rizwana, Milne, Andrew, Mulligan, John-Patrick, Nicklin, Philippa, Palipane, Natasha, Parsons, Thomas, Piper, Rebecca, Prakash, Rohan, Ramesh, Byron, Rasip, Sarah, Reading, Jacob, Rela, Mariam, Reyes, Anna, Robert, Stephens, Rooms, Martin, Shah, Karishma, Simons, Henry, Solanki, Shalil, Spowart, Emma, Stevens, Amy, Thomas, Christopher, Waggett, Helena, Yassaee, Arrash, Kennedy, Anthony, Scott, Sara, Somanath, Sameer, Berg, Andrew, Hernandez, Miguel, Nanda, Rajesh, Tank, Ghanshyambhai, Wilson, Natalie, Wilson, Debbie, Al-Soudaine, Yassr, Baldwin, Matthew, Cornish, Julie, Davies, Zoe, Davies, Leigh, Edwards, Marc, Frewer, Natasha, Gallard, Sian, Glasbey, James, Harries, Rhiannon, Hopkins, Luke, Kim, Taeyang, Koompirochana, Vilavan, Lawson, Simon, Lewis, Megan, Makzal, Zaid, Scourfield, Sarah, Ahmad, Yousra, Bates, Sarah, Blackwell, Clare, Bryant, Helen, Coulter, Suzanne, Cruickshank, Ross, Daniel, Sonya, Daubeny, Thomas, Edwards, Mark, Golder, Kim, Hawkins, Lesley, Helen, Bryant, Hinxman, Honor, Levett, Denny, Skinner, Ben, Walsgrove, Joseph, Bradburn, Mike, Dickson, Jane, Constantin, Kathryn, Karen, Markwell, O’Brien, Peter, O’Donohoe, Lynn, Payne, Hannah, Sundayi, Saul, Walker, Elaine, Brooke, Jenny, Cardy, Jon, Humphreys, Sally, Kessack, Laura, Kubitzek, Christiane, Kumar, Suhas, Cotterill, Donna, Hodzovic, Emil, Hosdurga, Gurunath, Miles, Edward, Saunders, Glenn, Campbell, Marta, Chan, Peter, Jemmett, Kim, Raj, Ashok, Naik, Aditi, Ramamoorthy, Rajarajan, Shah, Nimesh, Sylvan, Axel, Blyth, Katharine, Burtenshaw, Andrew, Freeman, David, Johnson, Emily, Lo, Philip, Martin, Terry, Plunkett, Emma, Wollaston, Julie, Allison, Joanna, Carroll, Christine, Craw, Nicholas, Craw, Sarah, Pitt-Kerby, Tressy, Rowland-Axe, Rebecca, Spurdle, Katie, McDonald, Andrew, Simon, Davies, Sinha, Vivek, Smith, Thomas, Banner-Goodspeed, Valerie, Boone, Myles, Campbell, Kathleen, Lu, Fengxin, Scannell, Joseph, Sobol, Julia, Balajonda, Naraida, Clemmons, Karen, Conde, Carlos, Funk, Bonita, Hall, Roger, Hopkins, Thomas, Olaleye, Omowunmi, Omer, Omer, Pender, Michelle, Porto, Angelo, Stevens, Alice, Waweru, Peter, Yeh, Erlinda, Bodansky, Daniella, Evans, Adam, Kleopoulos, Steven, Maril, Robert, Mathney, Edward, Sanchez, Angela, Tinuoye, Elizabeth, Bateman, Brian, Eng, Kristen, Jiang, Ning, Ladha, Karim, Needleman, Joseph, Chen, Lee-lynn, Chen, Lee-lynn, Lane, Rondall, Robinowitz, David, Ghushe, Neil, Irshad, Mariam, Patel, Samir, Takemoto, Steven, Wallace, Art, Mazzeffi, Michael, Rock, Peter, Wallace, Karin, Zhu, Xiaomao, Chua, Pandora, Fleisher, Lee, Mattera, Matthew, Sharar, Rebecca, Thilen, Stephan, Treggiari, Miriam, Morgan, Angela, Sofjan, Iwan, Subramaniam, Kathirvel, Avidan, Michael, Maybrier, Hannah, Muench, Maxwell, Wildes, Troy, and The International Surgical Outcomes Study (ISOS) group
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- 2017
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12. IMAGINE—IMpact Assessment of Guidelines Implementation and Education : The Next Frontier for Harmonising Urological Practice Across Europe by Improving Adherence to Guidelines
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the Pan-European National Urological Society IMAGINE Collaborative, Cornford, Philip, Smith, Emma Jane, MacLennan, Steven, Lahdensuo, Kanerva, Taari, Kimmo, Seikkula, Heikki, Jämsä, Pyry, HUS Abdominal Center, Faculty of Medicine, Clinicum, Urologian yksikkö, and Department of Surgery
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education ,3126 Surgery, anesthesiology, intensive care, radiology - Abstract
Publisher Copyright: © 2020 European Association of Urology Adherence to national and international clinical practice guidelines is suboptimal throughout Europe. The European Association of Urology Guidelines Office project “IMAGINE” (IMpact Assessment of Guidelines Implementation and Education) has been developed to measure baseline adherence to urological guideline recommendations across Europe and to identify issues that drive nonadherence. Non
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- 2021
13. The immune evasion protein Sbi of Staphylococcus aureus occurs both extracellularly and anchored to the cell envelope by binding lipoteichoic acid
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Smith, Emma Jane, Corrigan, Rebecca M., van der Sluis, Tetje, Gründling, Angelika, Speziale, Pietro, Geoghegan, Joan A., and Foster, Timothy J.
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- 2012
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14. IMAGINE—IMpact Assessment of Guidelines Implementation and Education: The Next Frontier for Harmonising Urological Practice Across Europe by Improving Adherence to Guidelines.
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Cornford, Philip, Smith, Emma Jane, MacLennan, Steven, Pereira-Azevedo, Nuno, Roobol, Monique J., Lumen, Nicolaas, Fullwood, Louise, Duncan, Eilidh, Dunsmore, Jennifer, Plass, Karin, Ribal, Maria J., Knoll, Thomas, Bjartell, Anders, Van Poppel, Hendrick, N'Dow, James, and Briganti, Alberto
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GUIDELINES , *UROLOGY , *OFFICES - Abstract
Adherence to national and international clinical practice guidelines is suboptimal throughout Europe. The European Association of Urology Guidelines Office project "IMAGINE" (IMpact Assessment of Guidelines Implementation and Education) has been developed to measure baseline adherence to urological guideline recommendations across Europe and to identify issues that drive nonadherence. [ABSTRACT FROM AUTHOR]
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- 2021
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15. European Association of Urology Guidelines Office: How We Ensure Transparent Conflict of Interest Disclosure and Management.
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Smith, Emma Jane, Plass, Karin, Darraugh, Julie, Shepherd, Robert, Briganti, Alberto, Cornford, Philip, Knoll, Thomas, Lumen, Nicolaas, N'Dow, James, Ribal, Maria J., Sylvester, Richard, van Poppel, Hendrik, and Bjartell, Anders
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CONFLICT of interests , *GUIDELINES , *UROLOGY , *OFFICES , *DISCLOSURE - Abstract
Conflicts of interest (COIs) can potentially introduce a risk of bias into the assessment of evidence and the formulation of recommendations for guidelines. It is essential that a systematic process for the disclosure and management of COIs is adopted to minimise potential bias in the guideline development process. [ABSTRACT FROM AUTHOR]
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- 2020
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16. Ensuring Consistent European-Wide Urological Care by the Use of Evidence-Based Clinical Practice Guidelines: Can We Do Better?
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Smith, Emma Jane, MacLennan, Steven, Bjartell, Anders, Briganti, Alberto, Knoll, Thomas, Loch, Tillmann, Ribal, Maria J., Sylvester, Richard, Van Poppel, Hein, and N'Dow, James
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- 2017
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17. The Ayre's T‐piece turns 80: A 21st century review.
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Oswald, Lauren, Smith, Emma‐Jane, Mathew, Malcolm, and Goonasekera, Chulananda
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PEDIATRIC anesthesia , *ANESTHESIA , *PEDIATRIC surgery , *CONDUCTION anesthesia in children , *PHYSICIAN practice patterns - Abstract
Summary: Ayre's T‐piece, first introduced 80 years ago, continues to be widely used in pediatric anesthesia despite colossal advances in equipment and technology. We present a review of its history, advantages, and disadvantages, and place in modern‐day clinical practice. [ABSTRACT FROM AUTHOR]
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- 2018
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18. Decision-making in intensive care: Influence of DNACPR status.
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Smith, Emma-Jane
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- 2019
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19. Your Brainwaves... Our Bargains!
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Boyd, Joyce, Smith, Emma Jane, Moreno, Amy, Vida, Eva, Savage, Jan, Griffin, T., Smith, Lilian, Angus, Sue, and Baldwin, Paul
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- 2016
20. Ireland joins block aimed at cutting cost of medicines.
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Ronan Smith; Emma Jane Hade
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SIMON Harris is today to sign an agreement which will allow Ireland to join a negotiating bloc of European countries set up to cut the cost of medications. [ABSTRACT FROM PUBLISHER]
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- 2018
21. Mapping European Association of Urology Guideline Practice Across Europe: An Audit of Androgen Deprivation Therapy Use Before Prostate Cancer Surgery in 6598 Cases in 187 Hospitals Across 31 European Countries.
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MacLennan, Steven, Azevedo, Nuno, Duncan, Eilidh, Dunsmore, Jennifer, Fullwood, Louise, Lumen, Nicolaas, Plass, Karin, Ribal, Maria J., Roobol, Monique J., Nieboer, Daan, Schouten, Natasha, Skolarus, Ted A., Smith, Emma Jane, N'Dow, James, Mottet, Nicolas, and Briganti, Alberto
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ANDROGEN deprivation therapy , *MEDICAL personnel , *PROSTATE surgery , *ONCOLOGIC surgery , *PROSTATE cancer , *PATIENT surveys , *RADIOTHERAPY - Abstract
Adherence to European Association of Urology guidelines to refrain from giving neoadjuvant androgen deprivation therapy (ADT) before prostate cancer surgery is variable, especially in high-risk subgroups. Inappropriate ADT use may cause serious harm to patients and the consequences are burdensome and costly for health care providers and payers. Evidence-practice gaps exist in urology. We previously surveyed European Association of Urology (EAU) guidelines for strong recommendations underpinned by high-certainty evidence that impact patient experience for which practice variations were suspected. The recommendation "Do not offer neoadjuvant androgen deprivation therapy (ADT) before surgery for patients with prostate cancer" was prioritised for further investigation. ADT before surgery is neither clinically effective nor cost effective and has serious side effects. The first step in improving implementation problems is to understand their extent. A clear picture of practice regarding ADT before surgery across Europe is not available. To assess current ADT use before prostate cancer surgery in Europe. This was an observational cross-sectional study. We retrospectively audited recent ADT practices in a multicentre international setting. We used nonprobability purposive sampling, aiming for breadth in terms of low- versus high-volume, academic, versus community and public versus private centres. Our primary outcome was adherence to the ADT recommendation. Descriptive statistics and a multilevel model were used to investigate differences between countries across different factors (volume, centre type, and funding type). Subgroup analyses were performed for patients with low, intermediate, and high risk, and for those with locally advanced prostate cancer. We also collected reasons for nonadherence. We included 6598 patients with prostate cancer from 187 hospitals in 31 countries from January 1, 2017 to May 1, 2020. Overall, nonadherence was 2%, (range 0–32%). Most of the variability was found in the high-risk subgroup, for which nonadherence was 4% (range 0–43%). Reasons for nonadherence included attempts to improve oncological outcomes or preoperative tumour parameters; attempts to control the cancer because of long waiting lists; and patient preference (changing one's mind from radiotherapy to surgery after neoadjuvant ADT had commenced or feeling that the side effects were intolerable). Although we purposively sampled for variety within countries (public/private, academic/community, high/low-volume), a selection bias toward centres with awareness of guidelines is possible, so adherence rates may be overestimated. EAU guidelines recommend against ADT use before prostate cancer surgery, yet some guideline-discordant ADT use remains at the cost of patient experience and an additional payer and provider burden. Strategies towards discontinuation of inappropriate preoperative ADT use should be pursued. Androgen deprivation therapy (ADT) is sometimes used in men with prostate cancer who will not benefit from it. ADT causes side effects such as weight gain and emotional changes and increases the risk of cardiovascular disease, diabetes, and osteoporosis. Guidelines strongly recommend that men opting for surgery should not receive ADT, but it is unclear how well the guidance is followed. We asked urologists across Europe how patients in their institutions were treated over the past few years. Most do not use ADT before surgery, but this still happens in some places. More research is needed to help doctors to stop using ADT in patients who will not benefit from it. [ABSTRACT FROM AUTHOR]
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- 2023
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22. Corrigendum to “Development of an international glossary for clinical guidelines collaboration” “[Journal of Clinical Epidemiology 158 (2023) 84-91]”
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Christensen, Rachel E., Yi, Michael D., Kang, Bianca Y., Ibrahim, Sarah A., Anvery, Noor, Dirr, McKenzie, Adams, Stephanie, Amer, Yasser S., Bisdorff, Alexandre, Bradfield, Lisa, Brown, Steve, Earley, Amy, Fatheree, Lisa A., Fayoux, Pierre, Getchius, Thomas, Ginex, Pamela, Graham, Amanda, Green, Courtney R., Gresele, Paolo, Hanson, Helen, Haynes, Norrisa, Hegedüs, Laszlo, Hussein, Heba, Jakhmola, Priya, Kantorova, Lucia, Krishnasamy, Rathika, Krist, Alex, Landry, Gregory, Lease, Erika D., Ley, Luis, Marsden, Gemma, Meek, Tim, Meremikwu, Martin, Moga, Carmen, Mokrane, Saphia, Mujoomdar, Amol, Newton, Skye, O'Flynn, Norma, Perkins, Gavin D., Smith, Emma-Jane, Prematunge, Chatura, Rychert, Jenna, Saraco, Mindy, Schünemann, Holger J., Senerth, Emily, Sinclair, Alan, Shwayder, James, Stec, Carla, Tanni, Suzana, Taske, Nichole, Temple-Smolkin, Robyn L., Thomas, Louise, Thomas, Sherene, Tonnessen, Britt, Turner, Amy S., Van Dam, Anne, van Doormaal, Mitchell, Wan, Yung Liang, Ventura, Christina B., McFarlane, Emma, Morgan, Rebecca L., Ogunremi, Toju, and Alam, Murad
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23. Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries
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Ahmad, T, Bouwman, RA, Grigoras, I, Aldecoa, C, Hofer, C, Hoeft, A, Holt, P, Fleisher, LA, Buhre, W, Pearse, RM, Ferguson, M, MacMahon, M, Shulman, M, Cherian, R, Currow, H, Kanathiban, K, Gillespie, D, Pathmanathan, E, Phillips, K, Reynolds, J, Rowley, J, Douglas, J, Kerridge, R, Garg, S, Bennett, M, Jain, M, Alcock, D, Terblanche, N, Cotter, R, Leslie, K, Stewart, M, Zingerle, N, Clyde, A, Hambidge, O, Rehak, A, Cotterell, S, Huynh, WBQ, McCulloch, T, Ben-Menachem, E, Egan, T, Cope, J, Halliwell, R, Fellinger, P, Haisjackl, M, Haselberger, S, Holaubek, C, Lichtenegger, P, Scherz, F, Schmid, W, Hoffer, F, Cakova, V, Eichwalder, A, Fischbach, N, Klug, R, Schneider, E, Vesely, M, Wickenhauser, R, Grubmueller, KG, Leitgeb, M, Lang, F, Toro, N, Bauer, M, Laengle, F, Haberl, C, Mayrhofer, T, Trybus, C, Buerkle, C, Forstner, K, Germann, R, Rinoesl, H, Schindler, E, Trampitsch, E, Bogner, G, Dankl, D, Duenser, M, Fritsch, G, Gradwohl-Matis, I, Hartmann, A, Hoelzenbein, T, Jaeger, T, Landauer, F, Lindl, G, Lux, M, Steindl, J, Stundner, O, Szabo, C, Bidgoli, J, Verdoodt, H, Forget, P, Kahn, D, Lois, F, Momeni, M, Pregardien, C, Pospiech, A, Steyaert, A, Veevaete, L, De Kegel, D, De Jongh, K, Foubert, L, Smitz, C, Vercauteren, M, Poelaert, J, Van Mossevelde, V, Abeloos, J, Bouchez, S, Coppens, M, De Baerdemaeker, L, Deblaere, I, De Bruyne, A, De Hert, S, Fonck, K, Heyse, B, Jacobs, T, Lapage, K, Moerman, A, Neckebroek, M, Parashchanka, A, Roels, N, Van Den Eynde, N, Vandenheuvel, M, Van Limmen, J, Vanluchene, A, Vanpeteghem, C, Wouters, P, Wyffels, P, Huygens, C, Vandenbempt, P, Van de Velde, M, Dylst, D, Janssen, B, Schreurs, E, Aleixo, FB, Candido, K, Batista, HD, Guimaraes, M, Guizeline, J, Hoffmann, J, Lobo, S, Marques Lobo, FR, Nascimento, V, Nishiyama, K, Pazetto, L, Souza, D, Rodrigues, RS, Vilela dos Santos, AM, Jardim, J, Sa Malbouisson, LM, Silva, J, Do Nascimento Junior, P, Baio, TH, Pereira de Castro, GI, Watanabe Oliveira, HR, Amendola, CP, Cardoso, G, Ortega, D, Brotto, AF, De Oliveira, MC, Rea-Neto, A, Dias, F, Travi, ME, Zerman, L, Azambuja, P, Knibel, MF, Martins, A, Almeida, W, Neder Neto, C, Tardelli, MA, Caser, E, Machado, M, Aguzzoli, C, Baldisserotto, S, Tabajara, FB, Bettega, F, Rodrigues Junior, LHC, De Gasperi, J, Faina, L, Nolasco, MF, Da Costa Fischer, BF, De Campos Ferreira, MF, Hartmann, C, Kliemann, M, Ribeiro, GLH, Fraga, JM, Netto, TM, Pozza, LV, Wendling, PR, Azevedo, C, Garcia, J, Lopes, M, Maia, B, Maselli, P, Melo, R, Mendes, W, Neves, M, Ney, J, Piras, C, Applewhaite, C, Carr, A, Chow, L, Duttchen, K, Foglia, J, Greene, M, Hinther, A, Houston, K, McCormick, TJ, Mikhayel, J, Montasser, S, Ragan, A, Suen, A, Woolsey, A, Yu, HC, Funk, D, Kowalski, S, Legaspi, R, McDonald, H, Siddiqui, F, Pridham, J, Rowe, B, Sampson, S, Thiessen, B, Zbitnew, G, Bernard, A, George, R, Jones, P, Moor, R, Siddiqui, N, Wolfer, A, Tran, D, Winch, D, Dobson, G, McCormick, T, Montasser, O, Hall, R, Baghirzada, L, Curley, G, Dai, SY, Hare, G, Lee, E, Shastri, U, Tsui, A, Yagnik, A, Alvares, D, Choi, S, Dwyer, H, Flores, K, McCartney, C, Somascanthan, P, Beattie, S, Carroll, J, Pazmino-Canizares, J, Wijeysundera, D, Ami, N, Chan, V, Perlas, A, Argue, R, Huang, Y, Lavis, K, Mayson, K, Cao, Y, Gao, H, Hu, T, Lv, J, Yang, J, Yang, Y, Zhong, Y, Zhou, J, Zou, X, He, M, Li, X, Luo, D, Wang, H, Yu, T, Chen, L, Wang, L, Cai, Y, Cao, Z, Li, Y, Lian, J, Sun, H, Wang, S, Wang, Z, Wang, K, Zhu, Y, Du, X, Fan, H, Fu, Y, Huang, L, Hwan, H, Luo, H, Qu, P-S, Tao, F, Wang, G, Zhang, Y, Zhang, X, Chen, C, Wang, W, Liu, Z, Fan, L, Tang, J, Chen, Y, Han, Y, Huang, C, Liang, G, Shen, J, Wang, J, Yang, Q, Zhen, J, Zhou, H, Chen, J, Chen, Z, Meng, B, Ye, H, Bi, Y, Cao, J, Guo, F, Lin, H, Liu, Y, Lv, M, Shi, P, Song, X, Sun, C, Sun, Y, Wang, Y, Zhang, M, Chen, R, Hou, J, Leng, Y, Meng, Q-T, Qian, L, Shen, Z-Y, Xia, Z-Y, Xue, R, Zhao, B, Zhou, X-J, Chen, Q, Guo, H, Guo, Y, Qi, Y, Wei, J, Zhang, W, Zheng, L, Bao, Q, Fei, Y, Hu, N, Hu, X, Lei, M, Lv, X, Miao, F, Ouyang, L, Shen, C, Wang, D, Wu, C, Xu, L, Yuan, J, Zhang, L, Zhang, H, Zhao, J, Zhao, C, Zhao, L, Zheng, T, Zhou, D, Zhou, C, Lu, K, Zhao, T, He, C, Chen, H, Chen, S, Cheng, B, He, J, Jin, L, Li, C, Li, H, Pan, Y, Shi, Y, Wen, XH, Wu, S, Xie, G, Zhang, K, Lu, X, Chen, F, Liang, Q, Lin, X, Ling, Y, Liu, G, Tao, J, Yang, L, Cheng, Z, Dai, H, Feng, Y, Hou, B, Gong, H, Hu, CH, Huang, H, Huang, J, Jiang, Z, Li, M, Lin, J, Liu, M, Liu, W, Luo, F, Ma, L, Min, J, Shi, X, Song, Z, Wan, X, Xiong, Y, Yang, S, Zhang, Q, Zhao, W, Zhu, X, Bai, Y, Dai, Q, Geng, W, Han, K, He, X, Ji, B, Jia, D, Jin, S, Li, Q, Liang, D, Luo, S, Lwang, L, Mo, Y, Qi, X, Qian, M, Qin, J, Ren, Y, Xie, J, Yan, Y, Yao, Y, Zhuang, X, Ai, Y, Du, F, He, L, Li, Z, Li, L, Meng, S, Yuan, Y, Zhang, E, Zhang, J, Zhao, S, Ji, Z, Pei, L, Dong, B, Li, J, Miao, Z, Mu, H, Qin, C, Su, L, Wen, Z, Xie, K, Yu, Y, Yuan, F, Xiao, W, Zhu, Z, Fu, K, Hu, R, Huang, S, Liang, Y, Yu, S, Guo, Z, Jing, Y, Tang, N, Wu, J, Yuan, 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T., Loots, Emil, Madansein, Rajhmum, Madaree, Anil, Madiba, Thandinkosi E., Manzini, Vukani T., Mbuyisa, Mbali, Moodley, Rajan, Msomi, Mduduzi, Mukama, Innocent, Naidoo, Desigan, Naidoo, Rubeshan, Naidu, Tesuven K., Ntloko, Sindiswa, Padayachee, Eneshia, Padayachee, Lucelle, Phaff, Martijn, Pillay, Bala, Pillay, Desigan, Pillay, Lutchmee, Ramnarain, Anupa, Ramphal, Suren R., Ryan, Paul, Saloojee, Ahmed, Sebitloane, Motshedisi, Sigcu, Noluyolo, Taylor, Jenna L., Torborg, Alexandra, Visser, Linda, Anderson, Philip, Conradie, Alae, De Swardt, Mathew, De Villiers, Martin, Eikman, Johan, Liebenberg, Riaan, Mouton, Johan, Paton, Abbey, Van Der Merwe, Louwrence, Wilscott-Davids, Candice, Barrett, Wendy Joan, Bester, Marlet, De Beer, Johan, Geldenhuys, Jacque, Gouws, Hanni, Potgieter, Jan-Hendrik, Strydom, Magdel, Wilberforceturton, Edwin, Chetty, Rubendraj R., Chirkut, Subash, Cronje, Larissa, De Vasconcellos, Kim, Dube, Nokukhanya Z., Gama, N. Sibusiso, Green, Garyth M., Green-Thompson, Randolph, Kinoo, Suman Mewa, Kistnasami, Prenolin, Maharaj, Kapil, Moodley, Manogaran S., Mothae, Sibongile J., Naidoo, Ruvashni, Noorbhai, M. Aslam F., Rughubar, Vivesh, Reddy, Jenendhiran, Singh, Avesh, Skinner, David L., Smith, Murray J., Singh, Bhagwan, Misra, Ravi, Naidoo, Maheshwar, Ramdharee, Pireshin, Selibea, Yvonne, Sewpersad, Selina, Sham, Shailendra, Wessels, Joseph D., Africander, Cucu, Bejia, Tarek, Blakemore, Stephen P., Botes, Marisa, Bunwarie, Bimalshakth, Hernandez, Carlos B., Jeeraz, Mohammud A., Legutko, Dagmara A., Lopez, Acela G., De Meyer, Jenine N., Muzenda, Tanaka, Naidoo, Noel, Patel, Maryam, Pentela, Rao, Junge, Marina, Mansoor, Naj, Rademan, Lana, Scislowski, Pawel, Seedat, Ismail, Van Den Berg, Bianca, Van Der Merwe, Doreen, Van Wyk, Steyn, Govender, Komalan, Naicker, Darshan, Ramjee, Rajesh, Saley, Mueen, Kuhn, Warren Paul, Matos-Puig, Roel, Moolla, Zaheer, Lisi, Alberto, Perez, Gisela, Beltran, Anna Valle, Lozano, Angel, Navarro, Carlos Delgado, Duca, Alejandro, Ernesto, Ernesto Pastor Martinez, Ferrando, Carlo, Fuentes, Isabel, GarcÃa-Pérez, Maria Luisa, Gracia, Estefania, Palomares, Ana Izquierdo, Katime, Antonio, Miã±ana, Amanda, Incertis, Raul Raul, Romero, Esther, Garcia, Carolina Soledad Romero, Rubio, Concepcion, Artiles, Tania Socorro, Soro, Marina, Valls, Paola, Laguarda, Gisela Alaman, Benavent, Pau, Cuenca, Vicente Chisbert, Cueva, Andreu, Lafuente, Matilde, Parra, Asuncion Marque, Rodrigo, Alejandra Romero, Sanchez-Morcillo, Silvia, Tormo, Sergi, Redondo, Francisco Javier, De Andres, Jose, Diago, Lorena Gómez, Cã¡diz, Maria José Hernández, Manuel, Granell Gil, Peris, Raquel, Saiz, Cristina, Tatay, Jose, Soto, Maria Teresa Tebar, Brunete, Tamara, Cancho, David, Garcãa, David R. Delgado, Zamudio, Diana, Del Valle, Santiago Garcia, Serrano, M. Luz, Alonso, Eduardo, Anillo, Victor, Maseda, Emilio, Salgado, Patricia, Suarez, Lui, Suarez-De-La-Rica, Alejandro, Villagrã¡n, MarÃa José, Aldecoa, Cesar, Alonso, José Ignacio, Cabezuelo, Estefania, Garcia-Saiz, Irene, Del Moral, Olga Lopez, Martãn, Silvia, Gonzalez, Alba Perez, Doncel, Ma Sherezade Tovar, Vera, Martin Agüero, Sanchez, Francisco José à vila, Castaã±o, Beatriz, Moreira, Beatriz Castaño, Risco, Sahely Flore, Martãn, Daniel Paz, Martãn, Fernando Pérez, Poza, Paloma, Ruiz, Adela, Martãnez, Wilson Fabio Serna, Vicente, Bárbara Vázquez, Dominguez, Saul Velaz, Fernã¡ndez, Salvador, Munoz-López, Alfonso, Bernat, Maria Jose, Mas, Arantxa, Planas, Kenneth, Jawad, Monir, Saeed, Yousif, Hedin, Annika, Levander, Helena, Chew, Michelle, Holmstrã¶m, Sandra, Lonn, David, Zoerner, Frank, à kring, Irene, Widmark, Carl, Zettergren, Jan, Liljequist, Victor Aspelund, Nystrom, Lena, Odeberg-Wernerman, Suzanne, Oldner, Ander, Fagerlund, Malin Jonsson, Reje, Patrik, Lyckner, Sara, Sperber, Jesper, Adolfsson, Anne, Klarin, Bengt, à gren, Katrin, Barras, Jean-Pierre, Bã¼hrer, Thoma, Despotidis, Vasileio, Helmy, Naeder, Holliger, Stephan, Raptis, Dimitri Aristotle, Schmid, Roger, Meyer, Antoine, Jaquet, Yve, Kessler, Ulf, Muradbegovic, Mirza, Nahum, Solange R., Rotunno, Teresa, Schiltz, Bori, Voruz, Franã§oi, Worreth, Marc, Christoforidis, Dimitri, Popeskou, Sotirios Georgio, Furrer, Marku, Prevost, Gian Andrea, Stocker, Andrea, Lang, Klau, Breitenstein, Stefan, Ganter, Michael T., Geisen, Martin, Soll, Christopher, Korkmaz, Michelle, Lubach, Iri, Schmitz, Michael, Zu Schwabedissen, Moritz Meyer, Zu Schwabedissen Moritz, Meyer, Zingg, Ur, Hillermann, Thoma, Wildi, Stefan, Hofer, Christoph, Pinto, Bernardo Bollen, Walder, Bernhard, Hã¼bner, Martin, Mariotti, Giustina, Slankamenac, Ksenija, Namuyuga, Mirioce, Kyomugisha, Edward, Kituuka, Olivia, Shikanda, Anne Wesonga, Kakembo, Nasser, Tom, Charles Otim, Antonina, Webombesa, Bua, Emmanuel, Ditai, Jame, Ssettabi, Eden Michael, Epodoi, Joseph, Kabagenyi, Fiona, Kirya, Fred, Dempsey, Ged, Seasman, Colette, Khan, Raja Basit Nawaz, Kurasz, Claire, Macgregor, Mark, Shawki, Burhan, Francis, Daren, Hariharan, Vimal, Chau, Simon, Ellis, Kate, Butt, Georgina, Chicken, Dennis-Wayne, Christmas, Natasha, Allen, Samantha, Daniel, Gayatri Daniel, Dempster, Angie, Kemp, Juliette, Matthews, Lewi, Mcglone, Philip, Tambellini, Joanne, Trodd, Dawn, Freitas, Katie, Garg, Atul, Gupta, Janesh Kumar, Karpate, Shilpaja, Kulkarni, Aditi, O'Hara, Chloe, Troko, Jtroko, Angus, Kirsty, Bradley, Jacqueline, Brennan, Emma, Brooks, Carolyn, Brown, Janette, Brown, Gemma, Finch, Amanda, Gratrix, Karen, Hesketh, Sue, Hill, Gillian, Jeffs, Carol, Morgan, Maureen, Pemberton, Chri, Slawson, Nicola, Spickett, Helen, Swarbrick, Gemma, Thomas, Megan, Van Duyvenvoorde, Greta, Brennan, Andrew, Briscoe, Richard, Cooper, Sarah, Lawton, Tom, Northey, Martin, Senaratne, Rashmi, Stanworth, Helen, Burrows, Lorna, Cain, Helen, Craven, Rachael, Davies, Keith, Jonas, Attila, Pachucki, Marcin, Walkden, Graham, Davies, Helen, Gudaca, Mariethel, Hobrok, Maria, Arawwawala, Dilshan, Fergey, Lauren, Gardiner, Matthew, Gunn, Jacqueline, Johnson, Lyndsay, Lofting, Amanda, Lyle, Amanda, Mcneela, Fiona, Smolen, Susan, Topliffe, Joanne, Williams, Sarah, Bland, Martin, Balaji, Packianathaswamy, Kaura, Vika, Lanka, Prasad, Naylor, Charde, Smith, Neil, Ahmed, Ahmed, Myatt, John, Shenoy, Ravikiran, Soon, Wai Cheong, Tan, Jessica, Karadia, Sunny, Durant, Emma, Tripathi, Shiva, Bullock, Clare, Campbell, Debbie, Ghosh, Alison, Hughes, Thoma, Zsisku, Lajo, Bengeri, Sheshagiri, Cowton, Amanda, Khalid, Mohammed Shazad, Limb, Jame, Mcadam, Colin, Porritt, Mandy, Rafi, M. Amir, Shekar, Priya, Adams, David, Harden, Catherine, Hollands, Heidi, King, Angela, March, Linda, Minto, Gary, Patrick, Abigail, Squire, Rosalyn, Waugh, Darren, Kumara, Paramesh, Simeson, Karen, Yarwood, Jamie, Browning, Julie, Hatton, Jonathan, Julian, Howe, Mitra, Atideb, Newton, Maria, Pernu, Pawan Kootelu, Wilson, Alison, Commey, Thelma, Foot, Helen, Glover, Lyn, Gupta, Ajay, Lancaster, Nicola, Levin, Jill, Mackenzie, Felicity, Mestanza, Claire, Nofal, Emma, Pout, Lauren, Varden, Rosanna, Wild, Jonathan, Jones, Stephanie, Moreton, Sarah, Pulletz, Mark, Davies, Charlotte, Martin, Matthew, Thomas, Sian, Burns, Karen, Mcarthur, Carol, Patel, Panna, Lau, Gary, Rich, Natalie, Davis, Fiona, Self, Jame, Lyons, Rachel, Port, Beth, Prout, Rachel, Smith, Christopher, Adelaja, Yemi, Bennett, Victoria, Bidd, Heena, Dumitrescu, Alexandra, Murphy, Jacqui Fox, Keen, Abigail, Mguni, Nhlanhla, Cheng, Ong, Adams, George, Boshier, Pier, Brown, Richard, Butryn, Izabella, Chatterjee, Jayanta, Freethy, Alexander, Lockwood, Geoffrey, Tsakok, Maria, Tsiligiannis, Sophia, Peat, William, Stephenson, Lorraine, Bradburn, Mike, Pick, Sara, Cunha, Pedro, Olagbaiye, Olufemi, Tayeh, Salim, Packianathaswamy, Balaji, Abernethy, Caroline, Balasubramaniam, Madhu, Bennett, Rachael, Bolton, David, Martinson, Victoria, Bell, Stephanie, Heather, Blaylock, Kushakovsky, Vlad, Alcock, Liam, Alexander, Hazel, Anderson, Colette, Baker, Paul, Brookes, Morag, Cawthorn, Louise, Cirstea, Emanuel, Clarkson, Rachel, Colling, Kerry, Coulter, Ian, Das, Suparna, Haigh, Kathryn, Hamdan, Alhafidz, Hugill, Keith, Kottam, Lucksy, Lisseter, Emily, Mawdsley, Matthew, Mcgivern, Julie, Padala, Krishnaveni, Phelps, Victoria, Kumar, Vineshykaa Ramesh, Stewart, Kirsten, Towse, Kayley, Tregonning, Julie, Vahedi, Ali, Walker, Alycon, Baines, Duncan, Bilolikar, Anjali, Chande, Shiv, Copley, Edward, Dunk, Nigel, Kulkarni, Raghavendra, Kumar, Pawan, Metodiev, Yavor, Ncomanzi, Dumisani, Raithatha, Bhavesh, Raymode, Parizade, Szafranski, Jan, Twohey, Linda, Watt, Philip, Weatherall, Lucie, Weatherill, J., Whitman, Zoe, Wighton, Elinor, Abayasinghe, Chamika, Chan, Alexander, Darwish, Sharif, Gill, Jame, Glasgow, Emma, Hadfield, Daniel, Harris, Clair, Hopkins, Phil, Kochhar, Arun, Kunst, Gudrun, Mellis, Clare, Pool, Andrew, Riozzi, Paul, Selman, Andrew, Smith, Emma-Jane, Vele, Liana, Gercek, Yuksel, Guy, Kramer, Holden, Dougla, Watson, Nichola, Whysall, Karen, Andreou, Prematie, Hales, Dawn, Thompson, Jonathan, Bowrey, Sarah, Mcdonald, Shara, Gilmore, Jemma, Hills, Vicky, Kelly, Chan, Kelly, Sinead, Lloyd, Geraint, Abbott, Tom, Gall, Lewi, Torrance, Hew, Vivian, Mark, Berntsen, Emer, Nolan, Tracey, Turner, Angu, Vohra, Akbar, Brown, Andrew, Clark, Richard, Coughlan, Elaine, Daniel, Conway, Patvardhan, Chinmay, Pearson, Rachel, Predeep, Sheba, Saad, Hesham, Shanmugam, Mohanakrishnan, Varley, Simon, Wylie, Katharine, Cooper, Lucy, Makowski, Arystarch, Misztal, Beata, Moldovan, Eliza, Pegg, Claire, Donovan, Andrew, Foot, Jayne, Large, Simon, Claxton, Andrew, Netke, Bhagyashree, Armstrong, Richard, Calderwood, Claire, Kwok, Andy, Mohr, Otto, Oyeniyi, Peter, Patnaik, Lisa, Post, Benjamin, Ali, Sarah, Arshad, Homa, Baker, Gerard, Brenner, Laura, Brincat, Maximilian, Brunswicker, Annemarie, Cox, Hannah, Cozar, Octavian Ionut, Cheong, Edward, Durst, Alexander, Fengas, Lior, Flatt, Jim, Glister, Georgina, Narwani, Vishal, Photi, Evangelo, Rankin, Adeline, Rosbergen, Melissa, Tan, Mark, Beaton, Ceri, Horn, Rachel, Hunt, Jane, Rousseau, Guy, Stancombe, Lucia, Absar, Mohammed, Allsop, Joanne, Drinkwater, Zoe, Hodgkiss, Tracey, Smith, Kirsty, Brown, Jamie, Alexander-Sefre, Farhad, Campey, Lorraine, Dudgeon, Lucy, Hall, Kathryn, Hitchcock, Rachael, James, Lynne, Smith, Kate, Winstone, Ulrika, Ahmad, Norfaizan, Bauchmuller, Kri, Harrison, Jonathan, Jeffery, Holly, Miller, Duncan, Pinder, Angela, Pothuneedi, Sailaja, Rosser, Jonathan, Sanghera, Sumayer, Swift, Diane, Walker, Rachel, Bester, Delia, Cavanagh, Sarah, Cripps, Heather, Daniel, Harvey, Lynch, Julie, Paton, Alison, Pyke, Shirley, Scholefield, John, Whitworth, Helen, Bottrill, Fiona, Ramalingam, Ganesh, Webb, Stephen, Akerman, Nik, Antill, Philip, Bourner, Lynsey, Buckley, Sarah, Castle, Gail, Charles, Rob, Eggleston, Christopher, Foster, Rebecca, Gill, Satwant, Lindley, Kate, Lklouk, Mohamed, Lowery, Tracey, Martin, Oliver, Milne, David, O'Connor, Patrick, Ratcliffe, Andrew, Rose, Alastair, Smith, Annie, Varma, Sandeep, Ward, Jackie, Barcraft-Barnes, Helena, Camsooksai, Julie, Colvin, Carolyn, Reschreiter, Henrik, Tbaily, Lee, Venner, Nicola, Hamilton, Caroline, Kelly, Lewi, Toth-Tarsoly, Piroska, Dodsworth, Kerry, Foord, Denise, Gordon, Paul, Hawes, Elizabeth, Lamb, Nikki, Mouland, Johanna, Nightingale, Jeremy, Rose, Steve, Schrieber, Joe, Al'Amri, Khalid, Aladin, Hafiz, Arshad, Mohammed Asif, Barraclough, Jame, Bentley, Conor, Bergin, Colin, Carrera, Ronald, Clarkson, Aisling, Collins, Michelle, Cooper, Lauren, Denham, Samuel, Griffiths, Ewen, Peter, Ip, Jeyanthan, Somasundaram, Joory, Kavita, Kaur, Satwant, Marriott, Paul, Mitchell, Natalie, Nagaiah, Sukumar, Nilsson, Annette, Parekh, Nilesh, Pope, Martin, Seager, Joseph, Serag, Hosam, Tameem, Alifia, Thomas, Anna, Thunder, Joanne, Torrance, Andrew, Vohra, Ravinder, Whitehouse, Arlo, Wong, Tony, Blunt, Mark, Wong, Kate, Giles, Julian, Reed, Isabelle, Weller, Debbie, Bell, Gillian, Birch, Julie, Damant, Rose, Maiden, Jane, Mewies, Clare, Prince, Claire, Radford, Jane, Reynolds, Tim, Balain, Birender, Banerjee, Robin, Barnett, Andrew, Burston, Ben, Davies, Kirsty, Edwards, Jayne, Evans, Chri, Ford, David, Gallacher, Pete, Hill, Simon, Jaffray, David, Karlakki, Sudheer, Kelly, Cormac, Kennedy, Julia, Kiely, Nigel, Lewthwaite, Simon, Marquis, Chri, Ockendon, Matthew, Phillips, Stephen, Pickard, Simon, Richardson, Jame, Roach, Richard, Smith, Tony, Spencer-Jones, Richard, Steele, Niall, Steen, Julie, Van Liefland, Marck, White, Steve, Faulds, Matthew, Harris, Meredyth, Kelly, Carrie, Nicol, Scott, Pearson, Sally Anne, Chukkambotla, Srikanth, Andrew, Alyson, Attrill, Elizabeth, Campbell, Graham, Datson, Amanda, Fouracres, Anna, Graterol, Juan, Graves, Lynne, Hong, Bosun, Ishimaru, Alexander, Karthikeyan, Arvind, King, Helen, Lawson, Tom, Lee, Gregory, Lyons, Saoirse, Hall, Andrew Macalister, Mathoulin, Sophie, Mcintyre, Eilidh, Mclaughlin, Danny, Mulcahy, Kathleen, Paddle, Jonathan, Ratcliffe, Anna, Robbins, Jame, Sung, Weilin, Tayo, Adeoluwa, Trembath, Lisa, Venugopal, Suneetha, Walker, Robert, Wigmore, Geoffrey, Boereboom, Catherine, Downes, Charlotte, Humphries, Ryan, Melbourne, Susan, Smith, Coral, Tou, Samson, Ullah, Shafa, Batchelor, Nick, Boxall, Leigh, Broomby, Rupert, Deen, Tariq, Hellewell, Alistair, Helliwell, Laurence, Hutchings, Melanie, Hutchins, David, Keenan, Samantha, Mackie, Donna, Potter, Alison, Smith, France, Stone, Lucy, Thorpe, Kevin, Wassall, Richard, Woodgate, Andrew, Baillie, Shelley, Campbell, Tara, James, Sarah, King, Chri, De Araujo, Daniela Marque, Martin, Danial, Morkane, Clare, Neely, Julia, Rajendram, Rajkumar, Burton, Megan, James, Kathryn, Keevil, Edward, Minik, Orsolya, Morgan, Jenna, Musgrave, Anna, Rajanna, Harish, Roberts, Tracey, Szakmany, Tama, Adamson, Michael, Jumbe, Sandra, Kendall, Jennie, Muthuswamy, Mohan Babu, Anderson, Charlotte, Cruikshanks, Andrew, Wrench, Ian, Zeidan, Lisa, Ardern, Diane, Harris, Benjamin, Hellstrom, Johanna, Martin, Jane, Thomas, Richard, Varsani, Nimu, Brown, Caroline Wrey, Docherty, Philip, Gillies, Michael, Mcgregor, Euan, Usher, Helen, Craig, Jayne, Smith, Andrew, Ahmad, Tahania, Bodger, Phoebe, Creary, Thai, Everingham, Kirsty, Fowler, Alexander, Hewson, Russell, Ijuo, Eke, Januszewska, Marta, Jones, Timothy, Kantsedikas, Ilya, Lahiri, Sumitra, Mclean, Aaron Lawson, Niebrzegowska, Edyta, Phull, Mandeep-Kaur, Wang, Difei, Wickboldt, Nadine, Baldwin, Jacqueline, Doyle, Donna, Mcmullan, Sean, Oladapo, Michelle, Owen, Thoma, Williams, Alexandra, Daniel, Hull, Gregory, Peter, Husain, Tauqeer, Kirk-Bayley, Justin, Mathers, Edward, Montague, Laura, Harper, Mark, White, Stuart, Jack, Jame, Ridley, Carrie, Avis, Joanne, Cook, Tim, Dali-Kemmery, Lola, Kerslake, Ian, Lambourne, Victoria, Pearson, Annabel, Boyd, Christine, Callaghan, Mark, Lawson, Cathy, Mccrossan, Roopa, Nesbitt, Vanessa, O'Connor, Laura, Scott, Julia, Sinclair, Rhona, Farid, Nahla, Morgese, Ciro, Bhatia, Kailash, Karmarkar, Swati, Ahmed, Jamil, Branagan, Graham, Hutton, Monica, Swain, Andrew, Brookes, Jamie, Cornell, Jonathan, Dolan, Rachael, Hulme, Jonathan, Van Vuuren, Amanda Jansen, Jowitt, Tom, Kalashetty, Gunasheela, Lloyd, Fran, Patel, Kiran, Sherwood, Nichola, Brown, Lynne, Chandler, Ben, Deighton, Kerry, Emma, Temlett, Haunch, Kirsty, Cheeseman, Michelle, Dent, Kathy, Garg, Sanjeev, Gray, Carol, Hood, Marion, Jones, Dawn, Juj, Joanne, Rao, Roshan, Walker, Tara, Al Anizi, Mashel, Cheah, Clarissa, Cheing, Yushio, Coutinho, Francisco, Gondo, Prisca, Hadebe, Bernard, Hove, Mazvangu Onie, Khader, Ahamed, Krishnachetty, Bobby, Rhodes, Karen, Sokhi, Jagdish, Baker, Katie-Anne, Bertram, Wendy, Looseley, Alex, Mouton, Ronelle, Hanna, George, Arnold, Glenn, Arya, Shobhit, Balfoussia, Danai, Baxter, Linden, Harris, Jame, Jones, Craig, Knaggs, Alison, Markar, Sheraz, Perera, Anisha, Scott, Alasdair, Shida, Asako, Sirha, Ravneet, Wright, Sally, Frost, Victoria, Gray, Catherine, Andrews, Emma, Arrandale, Lindsay, Barrett, Stephen, Cifra, Elna, Cooper, Mariese, Dragnea, Drago, Elna, Cifra, Maclean, Jennifer, Meier, Sonja, Milliken, Donald, Munns, Christopher, Ratanshi, Nadir, Ramessur, Suneil, Salvana, Abegail, Watson, Anthony, Hani, Ali, Campbell, Gill, Critchley, Rebecca, Endersby, Simon, Hicks, Catherine, Liddle, Alison, Pass, Marc, Ritchie, Charlotte, Thomas, Charlotte, Too, Lingxi, Welsh, Sarah, Gill, Talvinder, Johnson, Joanne, Reed, Joanne, Davis, Edward, Papadopoullos, Sam, Attwood, Clare, Biffen, Andrew, Boulton, Kerenza, Gray, Sophie, Hay, David, Mills, Sarah, Montgomery, Jane, Riddell, Rory, Simpson, Jame, Bhardwaj, Neeraj, Paul, Elaine, Uwubamwen, Nosakhare, Alexander, Maini, Arrich, Jame, Arumugam, Swarna, Blackwood, Dougla, Boggiano, Victoria, Brown, Robyn, Chan, Yik Lam, Chatterjee, Devnandan, Chhabra, Ashok, Christian, Rachel, Costelloe, Hannah, Matthewman, Madeline Coxwell, Dalton, Emma, Darko, Julia, Davari, Maria, Dave, Tejal, Deacon, Matthew, Deepak, Shantal, Edmond, Holly, Ellis, Jessica, El-Sayed, Ahmed, Eneje, Philip, English, Rose, Ewe, Renee, Foers, William, Franklin, John, Gallego, Laura, Garrett, Emily, Goldberg, Olivia, Goss, Harry, Greaves, Rosanna, Harris, Rudy, Hennings, Charle, Jones, Eleanor, Kamali, Nelson, Kokkinos, Naomi, Lewis, Cary, Lignos, Leda, Malgapo, Evaleen Victoria, Malik, Rizwana, Milne, Andrew, Mulligan, John-Patrick, Nicklin, Philippa, Palipane, Natasha, Parsons, Thoma, Piper, Rebecca, Prakash, Rohan, Ramesh, Byron, Rasip, Sarah, Reading, Jacob, Rela, Mariam, Reyes, Anna, Robert, Stephen, Rooms, Martin, Shah, Karishma, Simons, Henry, Solanki, Shalil, Spowart, Emma, Stevens, Amy, Thomas, Christopher, Waggett, Helena, Yassaee, Arrash, Kennedy, Anthony, Scott, Sara, Somanath, Sameer, Berg, Andrew, Miguel, Hernandez, Nanda, Rajesh, Tank, Ghanshyambhai, Wilson, Natalie, Wilson, Debbie, Al-Soudaine, Yassr, Baldwin, Matthew, Cornish, Julie, Davies, Zoe, Davies, Leigh, Edwards, Marc, Frewer, Natasha, Gallard, Sian, Glasbey, Jame, Harries, Rhiannon, Hopkins, Luke, Kim, Taeyang, Koompirochana, Vilavan, Lawson, Simon, Lewis, Megan, Makzal, Zaid, Scourfield, Sarah, Ahmad, Yousra, Bates, Sarah, Blackwell, Clare, Bryant, Helen, Collins, Hannah, Coulter, Suzanne, Cruickshank, Ro, Daniel, Sonya, Daubeny, Thoma, Edwards, Mark, Golder, Kim, Hawkins, Lesley, Helen, Bryant, Hinxman, Honor, Levett, Denny, Salmon, Karen, Seaward, Leanne, Skinner, Ben, Tyrell, Bryony, Wadams, Beverley, Walsgrove, Joseph, Dickson, Jane, Constantin, Kathryn, Karen, Markwell, O'Brien, Peter, O'Donohoe, Lynn, Payne, Hannah, Sundayi, Saul, Walker, Elaine, Brooke, Jenny, Cardy, Jon, Humphreys, Sally, Kessack, Laura, Kubitzek, Christiane, Kumar, Suha, Cotterill, Donna, Hodzovic, Emil, Hosdurga, Gurunath, Miles, Edward, Saunders, Glenn, Campbell, Marta, Chan, Peter, Jemmett, Kim, Raj, Ashok, Naik, Aditi, Oshowo, Ayo, Ramamoorthy, Rajarajan, Shah, Nimesh, Sylvan, Axel, Blyth, Katharine, Burtenshaw, Andrew, Freeman, David, Johnson, Emily, Philip, Lo, Martin, Terry, Plunkett, Emma, Wollaston, Julie, Allison, Joanna, Carroll, Christine, Craw, Nichola, Craw, Sarah, Pitt-Kerby, Tressy, Rowland-Axe, Rebecca, Spurdle, Katie, Mcdonald, Andrew, Simon, Davie, Sinha, Vivek, Smith, Thoma, Banner-Goodspeed, Valerie, Boone, Myle, Campbell, Kathleen, Fengxin, Lu, Scannell, Joseph, Sobol, Julia, Balajonda, Naraida, Clemmons, Karen, Conde, Carlo, Elgasim, Magdi, Funk, Bonita, Hall, Roger, Hopkins, Thoma, Olaleye, Omowunmi, Omer, Omer, Pender, Michelle, Porto, Angelo, Stevens, Alice, Waweru, Peter, Yeh, Erlinda, Bodansky, Daniella, Evans, Adam, Kleopoulos, Steven, Maril, Robert, Mathney, Edward, Sanchez, Angela, Tinuoye, Elizabeth, Bateman, Brian, Eng, Kristen, Jiang, Ning, Ladha, Karim, Needleman, Joseph, Chen, Lee-Lynn, Lane, Rondall, Robinowitz, David, Ghushe, Neil, Irshad, Mariam, O'Connor, John, Patel, Samir, Myles, Paul, Hiesmayr, Michael, Fang, Xiangming, Slim, Karem, Sander, Michael, Koulenti, Despoina, Chan, Mathew, Abbas, Muntadhar, Sivasakthi, Datin, Osinaike, Tunde, Matos, Ricardo, Grigoras, Ioana, Hubner, Martyn, Other departments, The International Surgical Outcomes Study, Group, Beretta, L, Landoni, G, and Zangrillo, A
- Subjects
Critical Care/utilization ,Postoperative Complications/epidemiology ,Male ,cohort studies, critical care/utilisation, operative/mortality, postoperative care/methods, postoperative care/statistics and numerical data, surgery, surgical procedures ,Global Health ,law.invention ,surgery ,Postoperative Complications ,0302 clinical medicine ,Correction Notice ,cohort studies ,Anesthesiology ,030202 anesthesiology ,law ,cohort studiescritical care/utilisationoperative/mortalitypostoperative care/methodspostoperative care/statistics and numerical datasurgerysurgical procedures ,80 and over ,Hospital Mortality ,Prospective Studies ,030212 general & internal medicine ,Prospective cohort study ,Aged, 80 and over ,International Surgical Outcomes Study group ,Elective Surgical Procedures/mortality ,HCC NEF ,Middle Aged ,Elective Surgical Procedures/adverse effects ,Intensive care unit ,surgical procedure ,3. Good health ,Treatment Outcome ,Length of Stay/statistics & numerical data ,operative/mortality ,Elective Surgical Procedures ,Female ,Elective Surgical Procedure ,Life Sciences & Biomedicine ,Cohort study ,Adult ,medicine.medical_specialty ,Adolescent ,Critical Care ,critical care/utilisation ,postoperative care/methods ,postoperative care/statistics and numerical data ,surgical procedures ,Aged ,Humans ,Length of Stay ,Poverty ,Socioeconomic Factors ,Young Adult ,Anesthesiology and Pain Medicine ,NO ,Clinical Practice ,03 medical and health sciences ,Intensive care ,Journal Article ,medicine ,postoperative care/method ,Elective surgery ,Science & Technology ,business.industry ,Postoperative complication ,030208 emergency & critical care medicine ,1103 Clinical Sciences ,Surgery ,Global Health/statistics & numerical data ,Emergency medicine ,business ,cohort studie - Abstract
Background:As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. Methods:We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. Results:A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44814 patients with a median hospital stay of 4 (range 2–7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. Conclusions:Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. Study registration:ISRCTN51817007
- Published
- 2016
24. Corrigendum to "Development of an international glossary for clinical guidelines collaboration" "[Journal of Biomechanics 158 (2023) 84-91]".
- Author
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Christensen RE, Yi MD, Kang BY, Ibrahim SA, Anvery N, Dirr M, Adams S, Amer YS, Bisdorff A, Bradfield L, Brown S, Earley A, Fatheree LA, Fayoux P, Getchius T, Ginex P, Graham A, Green CR, Gresele P, Hanson H, Haynes N, Hegedüs L, Hussein H, Jakhmola P, Kantorova L, Krishnasamy R, Krist A, Landry G, Lease ED, Ley L, Marsden G, Meek T, Meremikwu M, Moga C, Mokrane S, Mujoomdar A, Newton S, O'Flynn N, Perkins GD, Smith EJ, Prematunge C, Rychert J, Saraco M, Schünemann HJ, Senerth E, Sinclair A, Shwayder J, Stec C, Tanni S, Taske N, Temple-Smolkin RL, Thomas L, Thomas S, Tonnessen B, Turner AS, Van Dam A, van Doormaal M, Wan YL, Ventura CB, McFarlane E, Morgan RL, Ogunremi T, and Alam M
- Published
- 2024
- Full Text
- View/download PDF
25. PIONEER big data platform for prostate cancer: lessons for advancing future real-world evidence research.
- Author
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Lawlor A, Beyer K, Russell B, Steinbeisser C, Bjartell A, De Meulder B, Omar MI, Hulsen T, Butler J, N'Dow J, Rivas JG, Gandaglia G, Nicoletti R, Sakalis V, Smith EJ, Maass M, Zong J, Fullwood L, Abbott T, Tafreshiha A, Papineni K, Snijder R, Horgan D, Seager S, Evans-Axelsson S, Ribal MJ, Roobol MJ, and Van Hemelrijck M
- Abstract
Prostate Cancer Diagnosis and Treatment Enhancement through the Power of Big Data in Europe (PIONEER) is a European network of excellence for big data in prostate cancer. PIONEER brings together 34 private and public stakeholders from 9 countries in one multidisciplinary research consortium with the aim of positively transforming the field of prostate cancer clinical care by answering pressing questions related to prostate cancer screening, diagnosis and treatment. PIONEER has developed a unique state-of-the-art big data analytic platform by integrating existing data sources from patients with prostate cancer. PIONEER leveraged this platform to address prioritized research questions, filling knowledge gaps in the characterization, management and core outcomes of prostate cancer across the different disease stages. The network has benefited from sustained patient and stakeholder involvement and engagement, but many challenges remain when using real-world data for big data projects. To continue to advance prostate cancer care, data need to be available, suitable methodologies should be selected and mechanisms for knowledge sharing must be in place. Now acting as the prostate cancer arm of the European Association of Urology's new endeavour, UroEvidenceHub, PIONEER maintains its goal of maximizing the potential of big data to improve prostate cancer care., (© 2024. Springer Nature Limited.)
- Published
- 2024
- Full Text
- View/download PDF
26. Author Correction: Introducing PIONEER: a project to harness big data in prostate cancer research.
- Author
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Omar MI, Roobol MJ, Ribal MJ, Abbott T, Agapow PM, Araujo S, Asiimwe A, Auffray C, Balaur I, Beyer K, Bernini C, Bjartell A, Briganti A, Butler-Ransohoff JE, Campi R, Cavelaars M, De Meulder B, Devecseri Z, Voss MD, Dimitropoulos K, Evans-Axelsson S, Franks B, Fullwood L, Horgan D, Smith EJ, Kiran A, Kivinummi K, Lambrecht M, Lancet D, Lindgren P, MacLennan S, MacLennan S, Nogueira MM, Moen F, Moinat M, Papineni K, Reich C, Reiche K, Rogiers S, Sartini C, van Bochove K, van Diggelen F, Van Hemelrijck M, Van Poppel H, Zong J, and N'Dow J
- Abstract
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
- Published
- 2020
- Full Text
- View/download PDF
27. European Association of Urology Guidelines Office Rapid Reaction Group: An Organisation-wide Collaborative Effort to Adapt the European Association of Urology Guidelines Recommendations to the Coronavirus Disease 2019 Era.
- Author
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Ribal MJ, Cornford P, Briganti A, Knoll T, Gravas S, Babjuk M, Harding C, Breda A, Bex A, Rassweiler JJ, Gözen AS, Pini G, Liatsikos E, Giannarini G, Mottrie A, Subramaniam R, Sofikitis N, Rocco BMC, Xie LP, Witjes JA, Mottet N, Ljungberg B, Rouprêt M, Laguna MP, Salonia A, Bonkat G, Blok BFM, Türk C, Radmayr C, Kitrey ND, Engeler DS, Lumen N, Hakenberg OW, Watkin N, Hamid R, Olsburgh J, Darraugh J, Shepherd R, Smith EJ, Chapple CR, Stenzl A, Van Poppel H, Wirth M, Sønksen J, and N'Dow J
- Subjects
- COVID-19, Coronavirus Infections complications, Europe, Humans, Pandemics, Pneumonia, Viral complications, SARS-CoV-2, Urologic Diseases complications, Urologic Diseases diagnosis, Betacoronavirus, Coronavirus Infections epidemiology, Disease Management, Pneumonia, Viral epidemiology, Practice Guidelines as Topic, Societies, Medical, Urologic Diseases therapy, Urology standards
- Abstract
The coronavirus disease 2019 (COVID-19) pandemic is unlike anything seen before by modern science-based medicine. Health systems across the world are struggling to manage it. Added to this struggle are the effects of social confinement and isolation. This brings into question whether the latest guidelines are relevant in this crisis. We aim to support urologists in this difficult situation by providing tools that can facilitate decision making, and to minimise the impact and risks for both patients and health professionals delivering urological care, whenever possible. We hope that the revised recommendations will assist urologist surgeons across the globe to guide the management of urological conditions during the current COVID-19 pandemic., (Copyright © 2020. Published by Elsevier B.V.)
- Published
- 2020
- Full Text
- View/download PDF
28. Introducing PIONEER: a project to harness big data in prostate cancer research.
- Author
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Omar MI, Roobol MJ, Ribal MJ, Abbott T, Agapow PM, Araujo S, Asiimwe A, Auffray C, Balaur I, Beyer K, Bernini C, Bjartell A, Briganti A, Butler-Ransohoff JE, Campi R, Cavelaars M, De Meulder B, Devecseri Z, Voss MD, Dimitropoulos K, Evans-Axelsson S, Franks B, Fullwood L, Horgan D, Smith EJ, Kiran A, Kivinummi K, Lambrecht M, Lancet D, Lindgren P, MacLennan S, MacLennan S, Nogueira MM, Moen F, Moinat M, Papineni K, Reich C, Reiche K, Rogiers S, Sartini C, van Bochove K, van Diggelen F, Van Hemelrijck M, Van Poppel H, Zong J, and N'Dow J
- Subjects
- Humans, Male, Big Data, Biomedical Research, Prostatic Neoplasms
- Abstract
Prostate Cancer Diagnosis and Treatment Enhancement Through the Power of Big Data in Europe (PIONEER) is a European network of excellence for big data in prostate cancer, consisting of 32 private and public stakeholders from 9 countries across Europe. Launched by the Innovative Medicines Initiative 2 and part of the Big Data for Better Outcomes Programme (BD4BO), the overarching goal of PIONEER is to provide high-quality evidence on prostate cancer management by unlocking the potential of big data. The project has identified critical evidence gaps in prostate cancer care, via a detailed prioritization exercise including all key stakeholders. By standardizing and integrating existing high-quality and multidisciplinary data sources from patients with prostate cancer across different stages of the disease, the resulting big data will be assembled into a single innovative data platform for research. Based on a unique set of methodologies, PIONEER aims to advance the field of prostate cancer care with a particular focus on improving prostate-cancer-related outcomes, health system efficiency by streamlining patient management, and the quality of health and social care delivered to all men with prostate cancer and their families worldwide.
- Published
- 2020
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- View/download PDF
29. The Ayre's T-piece turns 80: A 21 st century review.
- Author
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Oswald L, Smith EJ, Mathew M, and Goonasekera C
- Subjects
- Anesthesiology history, Anesthesiology instrumentation, Child, History, 20th Century, History, 21st Century, Humans, Anesthesia, Inhalation history, Anesthesia, Inhalation instrumentation
- Abstract
Ayre's T-piece, first introduced 80 years ago, continues to be widely used in pediatric anesthesia despite colossal advances in equipment and technology. We present a review of its history, advantages, and disadvantages, and place in modern-day clinical practice., (© 2018 John Wiley & Sons Ltd.)
- Published
- 2018
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30. The Sbi protein is a multifunctional immune evasion factor of Staphylococcus aureus.
- Author
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Smith EJ, Visai L, Kerrigan SW, Speziale P, and Foster TJ
- Subjects
- Antigens, Bacterial genetics, Antigens, Bacterial immunology, Bacterial Adhesion, Bacterial Capsules genetics, Bacterial Capsules immunology, Bacterial Proteins genetics, Bacterial Proteins immunology, Carrier Proteins genetics, Carrier Proteins immunology, Cells, Cultured, Coagulase genetics, Coagulase immunology, Complement C3 biosynthesis, Complement C3 immunology, Complement C3 metabolism, Humans, Immunoglobulin G metabolism, Phagocytosis, Protein Binding immunology, Protein Structure, Tertiary, Receptors, Cell Surface genetics, Receptors, Cell Surface immunology, Staphylococcal Infections immunology, Staphylococcal Protein A genetics, Staphylococcal Protein A immunology, Staphylococcus aureus genetics, Staphylococcus aureus metabolism, Bacterial Proteins metabolism, Carrier Proteins metabolism, Neutrophils immunology, Staphylococcus aureus immunology, Staphylococcus aureus pathogenicity
- Abstract
The second immunoglobulin-binding protein (Sbi) of Staphylococcus aureus has two N-terminal domains that bind the Fc region of IgG in a fashion similar to that of protein A and two domains that can bind to the complement protein C3 and promote its futile consumption in the fluid phase. It has been proposed that Sbi helps bacteria to avoid innate immune defenses. By comparing a mutant defective in Sbi with mutants defective in protein A, clumping factor A, iron-regulated surface determinant H, and capsular polysaccharide, it was shown that Sbi is indeed an immune evasion factor that promotes bacterial survival in whole human blood and the avoidance of neutrophil-mediated opsonophagocytosis. Sbi is present in the culture supernatant and is also associated with the cell envelope. S. aureus strains that expressed truncates of Sbi lacking N-terminal domains D1 and D2 (D1D2) or D3 and D4 (D3D4) or a C-terminal truncate that was no longer retained in the cell envelope were analyzed. Both the secreted and envelope-associated forms of Sbi contributed to immune evasion. The IgG-binding domains contributed only when Sbi was attached to the cell, while only the secreted C3-binding domains were biologically active.
- Published
- 2011
- Full Text
- View/download PDF
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