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1. The OPTIMIST study: optimisation of cost effectiveness through individualised FSH stimulation dosages for IVF treatment. A randomised controlled trial

Author

van Tilborg Theodora C, Eijkemans Marinus JC, Laven Joop SE, Koks Carolien AM, de Bruin Jan, Scheffer Gabrielle J, van Golde Ron JT, Fleischer Kathrin, Hoek Annemieke, Nap Annemiek W, Kuchenbecker Walter KH, Manger Petra A, Brinkhuis Egbert A, van Heusden Arne M, Sluijmer Alexander V, Verhoeff Arie, van Hooff Marcel HA, Friederich Jaap, Smeenk Jesper MJ, Kwee Janet, Verhoeve Harold R, Lambalk Cornelis B, Helmerhorst Frans M, van der Veen Fulco, Mol Ben Willem J, Torrance Helen L, and Broekmans Frank JM

Subjects
Ovarian reserve, Antral follicle count, IVF, Individualised FSH stimulation dosages, Live birth rate, Gynecology and obstetrics, RG1-991, Public aspects of medicine, RA1-1270
Abstract

Abstract Background Costs of in vitro fertilisation (IVF) are high, which is partly due to the use of follicle stimulating hormone (FSH). FSH is usually administered in a standard dose. However, due to differences in ovarian reserve between women, ovarian response also differs with potential negative consequences on pregnancy rates. A Markov decision-analytic model showed that FSH dose individualisation according to ovarian reserve is likely to be cost-effective in women who are eligible for IVF. However, this has never been confirmed in a large randomised controlled trial (RCT). The aim of the present study is to assess whether an individualised FSH dose regime based on an ovarian reserve test (ORT) is more cost-effective than a standard dose regime. Methods/Design Multicentre RCT in subfertile women indicated for a first IVF or intracytoplasmic sperm injection cycle, who are aged Discussion The results of this study will be integrated into a decision model that compares cost-effectiveness of the three dose-adjustment strategies to a standard dose strategy. The study outcomes will provide scientific foundation for national and international guidelines. Trial registration NTR2657

Published
2012
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2. The long-term costs and effects of tubal flushing with oil-based versus water-based contrast during hysterosalpingography

Author

van Welie, Nienke, Pham, Clarabelle T., van Rijswijk, Joukje, Dreyer, Kim, Verhoeve, Harold R., Hoek, Annemieke, de Bruin, Jan Peter, Nap, Annemiek W., van Hooff, Machiel H.A., Goddijn, Mariëtte, Hooker, Angelo B., Gijsen, Anna P., Traas, Maaike A.F., Smeenk, Jesper M.J., Sluijmer, Alexander V., Lambers, Marieke J., van Unnik, Gijsbertus A., de Koning, Cornelia H., Mozes, Alexander, Timmerman, Catharina C.M., Lambalk, Cornelis B., Karnon, Jonathan D., Mijatovic, Velja, and Mol, Ben Willem J.

Published
2021
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3. Individualized versus standard FSH dosing in women starting IVF/ICSI: an RCT. Part 1: The predicted poor responder

Author

van Tilborg, Theodora C, Torrance, Helen L, Oudshoorn, Simone C, Eijkemans, Marinus J C, Koks, Carolien A M, Verhoeve, Harold R, Nap, Annemiek W, Scheffer, Gabrielle J, Manger, A Petra, Schoot, Benedictus C, Sluijmer, Alexander V, Verhoeff, Arie, Groen, Henk, Laven, Joop S E, Mol, Ben Willem J, Broekmans, Frank J M, van Tilborg, Theodora C, Oudshoorn, Simone C, Eijkemans, Marinus J C, Mochtar, Monique H, Koks, Carolien A M, van Golde, Ron J T, Verhoeve, Harold R, Nap, Annemiek W, Scheffer, Gabrielle J, Manger, A Petra, Hoek, Annemieke, Schoot, Bendictus C, Oosterhuis, G Jur E, Kuchenbecker, Walter K H, Fleischer, Kathrin, de Bruin, Jan Peter, Sluijmer, Alexander V, Friederich, Jaap, Verhoeff, Arie, van Hooff, Marcel H A, van Santbrink, Evert J P, Brinkhuis, Egbert A, Smeenk, Jesper M J, Kwee, Janet, de Koning, Corry H, Groen, Henk, van Wely, Madelon, Lambalk, Cornelis B, Laven, Joop S E, Mol, Ben Willem J, Broekmans, Frank J M, and Torrance, Helen L

Published
2017
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4. Individualized versus standard FSH dosing in women starting IVF/ICSI: an RCT. Part 2: The predicted hyper responder

Author

Oudshoorn, Simone C, van Tilborg, Theodora C, Eijkemans, Marinus J C, Oosterhuis, G Jur E, Friederich, Jaap, van Hooff, Marcel H A, van Santbrink, Evert J P, Brinkhuis, Egbert A, Smeenk, Jesper M J, Kwee, Janet, de Koning, Corry H, Groen, Henk, Lambalk, Cornelis B, Mol, Ben Willem J, Broekmans, Frank J M, Torrance, Helen L, van Tilborg, Theodora C, Oudshoorn, Simone C, Eijkemans, Marinus J C, Mochtar, Monique H, Koks, Carolien A M, van Golde, Ron J T, Verhoeve, Harold R, Nap, Annemiek W, Scheffer, Gabrielle J, Manger, A Petra, Hoek, Annemieke, Schoot, Bendictus C, Oosterhuis, G Jur E, Kuchenbecker, Walter K H, Fleischer, Kathrin, de Bruin, Jan Peter, Sluijmer, Alexander V, Friederich, Jaap, Verhoeff, Arie, van Hooff, Marcel H A, van Santbrink, Evert J P, Brinkhuis, Egbert A, Smeenk, Jesper M J, Kwee, Janet, de Koning, Corry H, Groen, Henk, van Wely, Madelon, Lambalk, Cornelis B, Laven, Joop S E, Mol, Ben Willem J, Broekmans, Frank J M, and Torrance, Helen L

Published
2017
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5. Individualized FSH dosing based on ovarian reserve testing in women starting IVF/ICSI: a multicentre trial and cost-effectiveness analysis

Author

van Tilborg, Theodora C, Oudshoorn, Simone C, Eijkemans, Marinus J C, Mochtar, Monique H, van Golde, Ron J T, Hoek, Annemieke, Kuchenbecker, Walter K H, Fleischer, Kathrin, de Bruin, Jan Peter, Groen, Henk, van Wely, Madelon, Lambalk, Cornelis B, Laven, Joop S E, Mol, Ben Willem J, Broekmans, Frank J M, Torrance, Helen L, van Tilborg, Theodora C, Oudshoorn, Simone C, Eijkemans, Marinus J C, Mochtar, Monique H, Koks, Carolien A M, van Golde, Ron J T, Verhoeve, Harold R, Nap, Annemiek W, Scheffer, Gabrielle J, Manger, A Petra, Hoek, Annemieke, Schoot, Bendictus C, Oosterhuis, G Jur E., Kuchenbecker, Walter K H, Fleischer, Kathrin, de Bruin, Jan Peter, Sluijmer, Alexander V, Friederich, Jaap, Verhoeff, Arie, van Hooff, Marcel H A, van Santbrink, Evert J P, Brinkhuis, Egbert A, Smeenk, Jesper M J, Kwee, Janet, de Koning, Corry H, Groen, Henk, van Wely, Madelon, Lambalk, Cornelis B, Laven, Joop S E, Mol, Ben Willem J, Broekmans, Frank J M, and Torrance, Helen L

Published
2017
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8. Oil-Based or Water-Based Contrast for Hysterosalpingography in Infertile Women.

Author

Dreyer, Kim, van Rijswijk, Joukje, Mijatovic, Velja, Goddijn, Mariëtte, Verhoeve, Harold R., van Rooij, Ilse A. J., Hoek, Annemieke, Bourdrez, Petra, Nap, Annemiek W., Rijnsaardt-Lukassen, Henrike G. M., Timmerman, Catharina C. M., Kaplan, Mesrure, Hooker, Angelo B., Gijsen, Anna P., van Golde, Ron, van Heteren, Cathelijne F., Sluijmer, Alexander V., de Bruin, Jan-Peter, Smeenk, Jesper M. J., and de Boer, Jacoba A. M.

Subjects
*HYSTEROSALPINGOGRAPHY, *FEMALE infertility, *PREGNANCY, *CLINICAL trials, *HUMAN fertility, *THERAPEUTICS
Abstract

Background: Pregnancy rates among infertile women have been reported to increase after hysterosalpingography, but it is unclear whether the type of contrast medium used (oil-based or water-soluble contrast) influences this potential therapeutic effect.Methods: We performed a multicenter, randomized trial in 27 hospitals in the Netherlands in which infertile women who were undergoing hysterosalpingography were randomly assigned to undergo this procedure with the use of oil-based or water-based contrast. Subsequently, couples received expectant management or the women underwent intrauterine insemination. The primary outcome was ongoing pregnancy within 6 months after randomization. Outcomes were analyzed according to the intention-to-treat principle.Results: A total of 1119 women were randomly assigned to hysterosalpingography with oil contrast (557 women) or water contrast (562 women). A total of 220 of 554 women in the oil group (39.7%) and 161 of 554 women in the water group (29.1%) had an ongoing pregnancy (rate ratio, 1.37; 95% confidence interval [CI], 1.16 to 1.61; P<0.001), and 214 of 552 women in the oil group (38.8%) and 155 of 552 women in the water group (28.1%) had live births (rate ratio, 1.38; 95% CI, 1.17 to 1.64; P<0.001). Rates of adverse events were low and similar in the two groups.Conclusions: Rates of ongoing pregnancy and live births were higher among women who underwent hysterosalpingography with oil contrast than among women who underwent this procedure with water contrast. (Netherlands Trial Register number, NTR3270 .). [ABSTRACT FROM AUTHOR]

Published
2017
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