Search

Your search keyword '"Siontis, Konstantinos"' showing total 525 results
Start Over Author "Siontis, Konstantinos" Language english
525 results on '"Siontis, Konstantinos"'

3. Substrate Characterization and Outcomes of Ventricular Tachycardia Ablation in Amyloid Cardiomyopathy: A Multicenter Study

Author

Compagnucci, Paolo, Dello Russo, Antonio, Gasperetti, Alessio, Schiavone, Marco, Sehrawat, Ojasav, Hasegawa, Kanae, Mohanty, Sanghamitra, Liang, Jackson J., Kapa, Suraj, La Fazia, Vincenzo Mirco, Bogun, Frank, Stevenson, William G., Tondo, Claudio, Siontis, Konstantinos C., Tandri, Harikrishna, Santangeli, Pasquale, Natale, Andrea, and Casella, Michela

Published
2024
Full Text
View/download PDF

11. Patient-Level Artificial Intelligence–Enhanced Electrocardiography in Hypertrophic Cardiomyopathy: Longitudinal Treatment and Clinical Biomarker Correlations

Author

Siontis, Konstantinos C., Abreau, Sean, Attia, Zachi I., Barrios, Joshua P., Dewland, Thomas A., Agarwal, Priyanka, Balasubramanyam, Aarthi, Li, Yunfan, Lester, Steven J., Masri, Ahmad, Wang, Andrew, Sehnert, Amy J., Edelberg, Jay M., Abraham, Theodore P., Friedman, Paul A., Olgin, Jeffrey E., Noseworthy, Peter A., and Tison, Geoffrey H.

Published
2023
Full Text
View/download PDF

24. Artificial intelligence-guided screening for atrial fibrillation using electrocardiogram during sinus rhythm: a prospective non-randomised interventional trial

Author

Noseworthy, Peter A, Attia, Zachi I, Behnken, Emma M, Giblon, Rachel E, Bews, Katherine A, Liu, Sijia, Gosse, Tara A, Linn, Zachery D, Deng, Yihong, Yin, Jun, Gersh, Bernard J, Graff-Radford, Jonathan, Rabinstein, Alejandro A, Siontis, Konstantinos C, Friedman, Paul A, and Yao, Xiaoxi

Published
2022
Full Text
View/download PDF

25. Artificial Intelligence–Enabled Electrocardiogram for Atrial Fibrillation Identifies Cognitive Decline Risk and Cerebral Infarcts

Author

Weil, Erika L., Noseworthy, Peter A., Lopez, Camden L., Rabinstein, Alejandro A., Friedman, Paul A., Attia, Zachi I., Yao, Xiaoxi, Siontis, Konstantinos C., Kremers, Walter K., Christopoulos, Georgios, Mielke, Michelle M., Vemuri, Prashanthi, Jack, Clifford R., Jr., Gersh, Bernard J., Machulda, Mary M., Knopman, David S., Petersen, Ronald C., and Graff-Radford, Jonathan

Published
2022
Full Text
View/download PDF

26. When to replicate systematic reviews of interventions : consensus checklist

Author

Tugwell, Peter, Welch, Vivian Andrea, Karunananthan, Sathya, Maxwell, Lara J, Akl, Elie A, Avey, Marc T, Bhutta, Zulfiqar A, Brouwers, Melissa C, Clark, Jocalyn P, Cook, Sophie, Cuervo, Luis Gabriel, Curran, Janet Agnes, Ghogomu, Elizabeth Tanjong, Graham, Ian G, Grimshaw, Jeremy M, Hutton, Brian, Ioannidis, John P A, Jordan, Zoe, Jull, Janet Elizabeth, Kristjansson, Elizabeth, Langlois, Etienne V, Little, Julian, Lyddiatt, Anne, Martin, Janet E, Marušić, Ana, Mbuagbaw, Lawrence, Moher, David, Morton, Rachael L, Nasser, Mona, Page, Matthew J, Pardo, Jordi Pardo, Petkovic, Jennifer, Petticrew, Mark, Pigott, Terri, Pottie, Kevin, Rada, Gabriel, Rader, Tamara, Riddle, Alison Y, Rothstein, Hannah, Schüneman, Holger J, Shamseer, Larissa, Shea, Beverley J, Simeon, Rosiane, Siontis, Konstantinos C, Smith, Maureen, Soares-Weiser, Karla, Thavorn, Kednapa, Thavorn, David Tovey, Vachon, Brigitte, Valentine, Jeffery, Villemaire, Rebecca, Walker, Peter, Weeks, Laura, Wells, George, Wilson, David B, and White, Howard

Published
2020

29. The precordial R′ wave: A novel discriminator between cardiac sarcoidosis and arrhythmogenic right ventricular cardiomyopathy in patients presenting with ventricular tachycardia

Author

Hoogendoorn, Jarieke C., Venlet, Jeroen, Out, Yannick N.J., Man, Sumche, Kumar, Saurabh, Sramko, Marek, Dechering, Dirk G., Nakajima, Ikutaro, Siontis, Konstantinos C., Watanabe, Masaya, Nakamura, Yoshinori, Tedrow, Usha B., Bogun, Frank, Eckardt, Lars, Peichl, Petr, Stevenson, William G., and Zeppenfeld, Katja

Published
2021
Full Text
View/download PDF

36. Abstract 13567: Impact of Mavacamten on Artificial Intelligence Electrocardiographic Diagnosis of Hypertrophic Cardiomyopathy in the EXPLORER-HCM Trial

Author

Siontis, Konstantinos C, Barrios, Joshua P, Attia, Zachi I, Abreau, Sean A, Abraham, Theodore P, Olivotto, Iacopo, Oreziak, Artur, Barriales-Villa, Roberto, Masri, Ahmad, Lakdawala, Neal K, Agarwal, Priyanka, Balasubramanyam, Aarthi, Sehnert, Amy J, Friedman, Paul A, Olgin, Jeff E, Noseworthy, Peter A, and Tison, Geoffrey H

Published
2022
Full Text
View/download PDF

43. Artificial intelligence–enabled electrocardiograms for identification of patients with low ejection fraction: a pragmatic, randomized clinical trial

Author

Yao, Xiaoxi, Rushlow, David R., Inselman, Jonathan W., McCoy, Rozalina G., Thacher, Thomas D., Behnken, Emma M., Bernard, Matthew E., Rosas, Steven L., Akfaly, Abdulla, Misra, Artika, Molling, Paul E., Krien, Joseph S., Foss, Randy M., Barry, Barbara A., Siontis, Konstantinos C., Kapa, Suraj, Pellikka, Patricia A., Lopez-Jimenez, Francisco, Attia, Zachi I., Shah, Nilay D., Friedman, Paul A., and Noseworthy, Peter A.

Published
2021
Full Text
View/download PDF

45. Secondary tricuspid regurgitation: incidence, types, and outcomes in atrial fibrillation vs. sinus rhythm.

Author

Naser, Jwan A, Castrichini, Matteo, Ibrahim, Hossam H, Scott, Christopher G, Lin, Grace, Lee, Eunjung, Mankad, Rekha, Siontis, Konstantinos C, Eleid, Mackram F, Pellikka, Patricia A, Michelena, Hector I, Pislaru, Sorin V, and Nkomo, Vuyisile T

Subjects
TRICUSPID valve insufficiency, RIGHT heart atrium, ATRIAL fibrillation, HEART diseases, PULMONARY hypertension
Abstract

Background and Aims Incidence and types of secondary tricuspid regurgitation (TR) are not well defined in atrial fibrillation (AFib) and sinus rhythm (SR). Atrial secondary TR (A-STR) is associated with pre-existing AFib; however, close to 50% of patients with A-STR do not have AFib. The aim of this study was to assess incidence, types, and outcomes of ≥ moderate TR in AFib vs. SR. Methods Adults with and without new-onset AFib without structural heart disease or ≥ moderate TR at baseline were followed for the development of ≥ moderate TR. Tricuspid regurgitation types were pacemaker, left-sided valve disease, left ventricular (LV) dysfunction, pulmonary hypertension (PH), isolated ventricular, and A-STR. Results Among 1359 patients with AFib and 20 438 in SR, 109 and 378 patients developed ≥ moderate TR, respectively. The individual types of TR occurred more frequently in AFib related to the higher pacemaker implantation rates (1.12 vs. 0.19 per 100 person-years, P <.001), larger right atrial size (median 78 vs. 53 mL, P <.001), and higher pulmonary pressures (median 30 vs. 28 mmHg, P <.001). The most common TR types irrespective of rhythm were LV dysfunction-TR and A-STR. Among patients in SR, those with A-STR were older, predominantly women with more diastolic abnormalities and higher pulmonary pressures. All types of secondary TR were associated with all-cause mortality, highest in PH-TR and LV dysfunction-TR. Conclusions New-onset AFib vs. SR conferred a higher risk of the individual TR types related to sequelae of AFib and higher pacemaker implantation rates, although the distribution of TR types was similar. Secondary TR was universally associated with increased mortality. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

46. A Clinical Diagnostic Test for Calcium Release Deficiency Syndrome.

Author

Ni, Mingke, Dadon, Ziv, Ormerod, Julian O. M., Saenen, Johan, Hoeksema, Wiert F., Antiperovitch, Pavel, Tadros, Rafik, Christiansen, Morten K., Steinberg, Christian, Arnaud, Marine, Tian, Shanshan, Sun, Bo, Estillore, John Paul, Wang, Ruiwu, Khan, Habib R., Roston, Thomas M., Mazzanti, Andrea, Giudicessi, John R., Siontis, Konstantinos C., and Alak, Aiman

Subjects
ARRHYTHMIA, SUPRAVENTRICULAR tachycardia, DIAGNOSIS methods, VENTRICULAR tachycardia, CARDIAC pacing, CARDIAC arrest
Abstract

Key Points: Question: Cardiac arrest frequently occurs without explanation, even after a thorough clinical evaluation. Can a simple maneuver clinically diagnose calcium release deficiency syndrome (CRDS), a newly described cause of sudden death? Findings: In this international, multicenter, case-control study, a provoked measure of T-wave amplitude on an electrocardiogram ascertained cases of CRDS with high accuracy. The genetic mouse models recapitulated the human findings and suggested a pathologically large systolic calcium release from the sarcoplasmic reticulum was responsible. Meaning: These preliminary results suggest that the repolarization response on an electrocardiogram to brief tachycardia followed by a pause may effectively diagnose CRDS. Given the frequency of unexplained cardiac arrest, should these findings be confirmed in larger studies, this readily available maneuver may provide clinically actionable information. Importance: Sudden death and cardiac arrest frequently occur without explanation, even after a thorough clinical evaluation. Calcium release deficiency syndrome (CRDS), a life-threatening genetic arrhythmia syndrome, is undetectable with standard testing and leads to unexplained cardiac arrest. Objective: To explore the cardiac repolarization response on an electrocardiogram after brief tachycardia and a pause as a clinical diagnostic test for CRDS. Design, Setting, and Participants: An international, multicenter, case-control study including individual cases of CRDS, 3 patient control groups (individuals with suspected supraventricular tachycardia; survivors of unexplained cardiac arrest [UCA]; and individuals with genotype-positive catecholaminergic polymorphic ventricular tachycardia [CPVT]), and genetic mouse models (CRDS, wild type, and CPVT were used to define the cellular mechanism) conducted at 10 centers in 7 countries. Patient tracings were recorded between June 2005 and December 2023, and the analyses were performed from April 2023 to December 2023. Intervention: Brief tachycardia and a subsequent pause (either spontaneous or mediated through cardiac pacing). Main Outcomes and Measures: Change in QT interval and change in T-wave amplitude (defined as the difference between their absolute values on the postpause sinus beat and the last beat prior to tachycardia). Results: Among 10 case patients with CRDS, 45 control patients with suspected supraventricular tachycardia, 10 control patients who experienced UCA, and 3 control patients with genotype-positive CPVT, the median change in T-wave amplitude on the postpause sinus beat (after brief ventricular tachycardia at ≥150 beats/min) was higher in patients with CRDS (P <.001). The smallest change in T-wave amplitude was 0.250 mV for a CRDS case patient compared with the largest change in T-wave amplitude of 0.160 mV for a control patient, indicating 100% discrimination. Although the median change in QT interval was longer in CRDS cases (P =.002), an overlap between the cases and controls was present. The genetic mouse models recapitulated the findings observed in humans and suggested the repolarization response was secondary to a pathologically large systolic release of calcium from the sarcoplasmic reticulum. Conclusions and Relevance: There is a unique repolarization response on an electrocardiogram after provocation with brief tachycardia and a subsequent pause in CRDS cases and mouse models, which is absent from the controls. If these findings are confirmed in larger studies, this easy to perform maneuver may serve as an effective clinical diagnostic test for CRDS and become an important part of the evaluation of cardiac arrest. Case-control study including individual cases of calcium release deficiency syndrome (CRDS), 3 patient control groups, and genetic mouse models assesses the cardiac repolarization response on an electrocardiogram after brief tachycardia and a pause as a clinical diagnostic test for CRDS. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results