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In this paper we analyse the impact of mothers’ employment status and formal child care attendance during early childhood on children’s school grades later in life, controlling for socio-demographic factors. We use the year 2008 of the Italian ISFOL-PLUS dataset. The dataset provides information on each respondent’s demographic characteristics, as well as a set of retrospective information on the individual’s school grades at the end of junior high school, high school, and university, along with (in the 2008 wave only) information about the respondent’s formal child care attendance and mother’s employment status when he or she was under age of three. We estimate the effects of maternal employment and child care attendance on the probability that the respondent would have high grades at the end of high school. Since maternal employment and child care attendance are likely to be endogenously determined, we use an instrumental variable approach. Our empirical results show that while having a mother who was working (during early childhood) had no significant effect on an individual’s high school grades, child care attendance had a positive and significant effect. These results have potential policy implications. As maternal employment does not seem to negatively affect the development process of children, while child care attendance appears to have a positive impact on academic achievement, policy makers should consider expanding the availability of child care and promoting women’s participation in the labour market. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10680-015-9370-0) contains supplementary material, which is available to authorized users.

Purpose: The aim of this study was to acquire further insights into the pathogenetic pathways of head and neck squamous cell carcinomas (HNSCC) that may be useful for identifying new biomarkers instrumental in developing more specific treatment approaches. Experimental Design: Cell cycle regulators and epidermal growth factor receptor (EGFR) and BRAF genes were analyzed in a series of 90 oropharyngeal SCCs of a cohort of surgically treated patients from a single institution, and the results were matched with the presence of high-risk human papillomavirus (HR-HPV) DNA and the TP53 status. Results: At least four distinct groups of tumors were identified sharing a common histology but displaying different molecular/cytogenetic patterns: (a) 19% were HPV-positive SCCs whose lack of alterations of the investigated genes could explain their particular natural history, which requires less aggressive treatment; (b) 37% were HPV-negative SCCs carrying TP53 mutations, which may be more effectively treated by drugs acting through p53-independent apoptosis; (c) 34% were HPV-negative SCCs carrying wild-type TP53 and loss of 9p21 (p16INK4a and p15INK4b) and/or cyclin D1 overexpression that justify treatment with DNA-damaging drugs followed by cell cycle inhibitors; and (d) 10% were HPV-negative lacking tumor suppressor genes and cell cycle alterations. The second, third, and fourth groups also showed an increased copy number of EGFR and chromosome 7 (43%) that might justify the additional or alternative use of EGFR inhibitors. Conclusions: Our findings suggest that assessing HPV, TP53, 9p21, and EGFR status may be crucial to finding more tailored and beneficial treatments for oropharyngeal SCCs.