1. Antimicrobial silver-filled silica nanorattles with low immunotoxicity in dendritic cells
- Author
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Nina Suhartha Löwa, Priscilla S. Brunetto, Inès Mottas, Magdalena Priebe, Carole Bourquin, Sarah-Luise Abram, Nina Khanna, Anne-Kathrin Woischnig, Katharina M. Fromm, and Jérôme Widmer
- Subjects
Metal Nanoparticles ,Pharmaceutical Science ,Medicine (miscellaneous) ,02 engineering and technology ,Antibacterial effect ,medicine.disease_cause ,01 natural sciences ,Silver nanoparticle ,Mice ,chemistry.chemical_compound ,Silicon Dioxide/chemistry ,General Materials Science ,Cells, Cultured ,ddc:615 ,Escherichia coli/drug effects ,ddc:617 ,Absolute number ,Metal Nanoparticles/chemistry ,Silicon Dioxide ,021001 nanoscience & nanotechnology ,Antimicrobial ,Anti-Bacterial Agents ,3. Good health ,Staphylococcus aureus ,Dendritic Cells/drug effects/metabolism ,Drug delivery ,Molecular Medicine ,0210 nano-technology ,Silver ,Materials science ,Silicon dioxide ,Staphylococcus aureus/drug effects ,Biomedical Engineering ,Bioengineering ,Nanotechnology ,Microbial Sensitivity Tests ,010402 general chemistry ,Anti-Bacterial Agents/pharmacology ,Microbiology ,Silver/pharmacology ,Immune system ,Phagocytosis ,Escherichia coli ,medicine ,Animals ,Dendritic Cells ,0104 chemical sciences ,chemistry - Abstract
The progression in the use of orthopedic implants has led to an increase in the absolute number of implant infections, triggering a search for more effective antibacterial coatings. Nanorattles have recently gained interest in biomedical applications such as drug delivery, as encapsulation of the cargo inside the hollow structure provides a physical protection from the surrounding environment. Here, silver-containing silica nanorattles (Ag@SiO2) were evaluated for their antimicrobial potential and for their impact on cells of the immune system. We show that Ag@SiO2 nanorattles exhibited a clear antibacterial effect against Escherichia coli as well as Staphylococcus aureus found in post-operative infections. Immunotoxicological analyses showed that the particles were taken up through an active phagocytic process by dendritic cells of the immune system and did not affect their viability nor induce unwanted immunological effects. Silver-containing silica nanorattles thus fulfill several prerequisites for an antibacterial coating on surgical implants.
- Published
- 2017