1. 東北ジャーナル刊行会
- Author
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Hideaki Senjyu, Yuji Shiraishi, Mitsuru Tabusadani, Shunya Omatsu, and Yuki Kuroyama
- Subjects
Lung Diseases ,Male ,medicine.medical_specialty ,surgical treatment ,Mycobacterium Infections, Nontuberculous ,Disease ,Walking ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,0302 clinical medicine ,Postoperative Complications ,Quality of life ,Internal medicine ,Surveys and Questionnaires ,nontuberculous mycobacterial lung disease ,medicine ,Humans ,Clinical significance ,030212 general & internal medicine ,Respiratory system ,Exercise ,Lung ,business.industry ,Incidence (epidemiology) ,General Medicine ,Middle Aged ,Quadriceps femoris muscle ,health-related quality of life ,medicine.anatomical_structure ,Lung disease ,exertional tolerance ,030220 oncology & carcinogenesis ,Quality of Life ,Regression Analysis ,Female ,incremental shuttle walk distance ,business - Abstract
The incidence of nontuberculous mycobacterial lung disease (NTMLD) is increasing worldwide, the number of lung surgeries is increasing accordingly. The disease is progressive and is characterized by exertional intolerance, respiratory dysfunctions, and impaired health-related quality of life (HRQOL). Treatment comprises multidrug antibiotic treatment combined with lung resection. The incremental shuttle walk distance (ISWD) is a standard tool for assessing the patients' tolerance to lung resection. The exertional tolerance, physical functions and HRQOL among pre-surgical patients with NTMLD are clinically important, but not fully studied yet from the viewpoint of physiotherapy. The purpose of this study was to explore the clinical significance of ISWD for assessing the exercise capacity of pre-surgical patients with NTMLD. For peripheral muscle evaluation, the strength of the quadriceps femoris muscle was measured. HRQOL was evaluated using scores of the St. George's Respiratory Questionnaire (SGRQ). Thirty-three patients (mean age 54.9 ± 13 years) were enrolled. The mean ISWD was 505 ± 134 m, shorter than the reference values (ISWD %predicted: 96 ± 27%). Regression analysis showed significant associations between ISWD and percent-predicted vital capacity (r = 0.38, p = 0.03) and percent quadriceps force/body weight (r = 0.54, p = 0.001). HRQOL assessed by SGRQ scores was correlated with ISWD (r < -0.4, p < 0.05). Multiple regression analysis showed that ISWD was significantly associated with leg muscle strength and with HRQOL. In conclusion, ISWD is useful to evaluate the exercise capacity among pre-surgical patients with NTMLD, The Tohoku journal of experimental medicine, 250(1), pp.43-48; 2020
- Published
- 2020