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A palladium/chiral N,N′-disulfonyl bisimidazoline (Bim)-catalyzed asymmetric addition of arylboronic acids to isoquinoline-1,3,4-trione-derived ketimines is reported, leading to the generation of a series of functionalized isoquinoline-1,3(2H,4H)-diones bearing one quaternary carbon-amino functionality in good to excellent yields with ≥95% ee in most cases. The reaction has remarkable compatibility with both substrate scopes, providing a highly enantioselective entry to chiral heterocyclic α-tertiary amines.

Abstract Many researchers have explored the potential association between one neurosurgical disease and coronavirus disease 2019 (COVID-19), but few systematically analyzed the association and causality between COVID-19 and various neurosurgical diseases. A Mendelian randomization analysis was conducted to evaluate the causal association between COVID-19 (including critically ill COVID‐19, hospitalized COVID‐19, and respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection) and 30 neurosurgical diseases within European populations. The consequences of inverse variance weighted models suggest that genetic susceptibility of critically ill COVID-19 may increase the risk of cerebral infarction (odds ratio [OR] = 1.02; p‐value = 0.006), genetic susceptibility of SARS-CoV-2 infection may increase the risk of stroke (OR = 1.02; p‐value = 0.047), and conversely, genetic susceptibility of hospitalized COVID-19 may reduce the risk of pituitary adenoma and craniopharyngioma (OR = 0.90; p‐value = 0.032). In addition, evidences revealed potential associations between genetic susceptibility of COVID-19 and spinal stenosis (OR = 1.03; p‐value = 0.028), diffuse brain injury (OR = 1.21; p‐value = 0.040) and focal brain injury (OR = 1.12; p‐value = 0.040). By testing for heterogeneity and pleiotropy, the above causal conclusions are robust. In summary, our analysis shows that COVID-19 has an independent and powerful causal influence on multiple neurosurgical disorders.

Taking the Lower Permian Fengcheng Formation shale in Mahu Sag of Junggar Basin, NW China, as an example, core observation, test analysis, geological analysis and numerical simulation were applied to identify the shale oil micro-migration phenomenon. The hydrocarbon micro-migration in shale oil was quantitatively evaluated and verified by a self-created hydrocarbon expulsion potential method, and the petroleum geological significance of shale oil micro-migration evaluation was determined. Results show that significant micro-migration can be recognized between the organic-rich lamina and organic-poor lamina. The organic-rich lamina has strong hydrocarbon generation ability. The heavy components of hydrocarbon preferentially retained by kerogen swelling or adsorption, while the light components of hydrocarbon were migrated and accumulated to the interbedded felsic or carbonate organic-poor laminae as free oil. About 69% of the Fengcheng Formation shale samples in Well MY1 exhibit hydrocarbon charging phenomenon, while 31% of those exhibit hydrocarbon expulsion phenomenon. The reliability of the micro-migration evaluation results was verified by combining the group components based on the geochromatography effect, two-dimension nuclear magnetic resonance analysis, and the geochemical behavior of inorganic manganese elements in the process of hydrocarbon migration. Micro-migration is a bridge connecting the hydrocarbon accumulation elements in shale formations, which reflects the whole process of shale oil generation, expulsion and accumulation, and controls the content and composition of shale oil. The identification and evaluation of shale oil micro-migration will provide new perspectives for dynamically differential enrichment mechanism of shale oil and establishing a “multi-peak model in oil generation” of shale.

Background As a relatively novel approach to enhancing skeletal muscle health, mixed protein supplementation has shown similar responses to whey protein. However, no previous studies have examined its impact on golf swing performance. This study aimed to examine the effect of mixed protein supplementation on the swing performance and muscle strength of casual golfers.Methods Sixty participants with a handicap of less than 20 were recruited and randomly assigned to a double-blind, placebo-controlled study design. The participants were divided into two groups: a mixed protein group (MG, n = 30), and a placebo control group (CG, n = 30). They were instructed to ingest either a supplement containing casein calcium, whey protein, and isolated pea protein, or a placebo, once daily for 8 weeks. Pre- and posttests consisted of anthropometric measurements, muscle strength (isokinetic knee and trunk strength, and handgrip strength), 2-minute push-ups, balance, and golf swing performance using a driver and 7-iron.Results After the 8-week supplementation period, ANCOVA, using baseline values as covariates, revealed significant differences for driver distance (p = .004) and driver ball speed (p .05).Conclusion The intake of a mixed protein containing both animal and plant proteins had positive effects on golf performance and muscle function. Therefore, mixed proteins may represent a safe and effective approach to enhancing skeletal muscle health in golf players.

NAD(P)H:quinone oxidoreductase 1 (NQO1) is overexpressed in most solid cancers, emerging as a promising target for tumor-selective killing. β-Lapachone (β-Lap), an NQO1 bioactivatable drug, exhibits significant antitumor effects on NQO1-positive cancer cells by inducing immunogenic cell death (ICD) and enhancing tumor immunogenicity. However, the interaction between β-Lap-mediated antitumor immune responses and neutrophils, novel antigen-presenting cells (APCs), remains unknown. This study demonstrates that β-Lap selectively kills NQO1-positive murine tumor cells by significantly increasing intracellular ROS formation and inducing DNA double strand breaks (DSBs), resulting in DNA damage. Treatment with β-Lap efficiently eradicates immunocompetent murine tumors and significantly increases the infiltration of tumor-associated neutrophils (TANs) into the tumor microenvironment (TME), which plays a crucial role in the drug’s therapeutic efficacy. Further, the presence of β-Lap-induced antigen medium leads bone marrow-derived neutrophils (BMNs) to directly kill murine tumor cells, aiding in dendritic cells (DCs) recruitment and significantly enhancing CD8+ T cell proliferation. β-Lap treatment also drives the polarization of TANs toward an antitumor N1 phenotype, characterized by elevated IFN-β expression and reduced TGF-β cytokine expression, along with increased CD95 and CD54 surface markers. β-Lap treatment also induces N1 TAN-mediated T cell cross-priming. The HMGB1/TLR4/MyD88 signaling cascade influences neutrophil infiltration into β-Lap-treated tumors. Blocking this cascade or depleting neutrophil infiltration abolishes the antigen-specific T cell response induced by β-Lap treatment. Overall, this study provides comprehensive insights into the role of tumor-infiltrating neutrophils in the β-Lap-induced antitumor activity against NQO1-positive murine tumors.

Carbon catabolite repression (CCR) is a highly conserved mechanism that regulates carbon source utilization in Streptomyces. CCR has a negative impact on secondary metabolite fermentation, both in industrial and research settings. In this study, CCR was observed in the daunorubicin (DNR)-producing strain Streptomyces coeruleorubidus DM, which was cultivated in high concentration of carbohydrates. Unexpectedly, DM exhibited a high ability for anthraquinone glucuronidation biotransformation under CCR conditions with a maximum bioconversion rate of 95% achieved at pH 6, 30°C for 24 h. The co-utilization of glucose and sucrose resulted in the highest biotransformation rate compared to other carbon source combinations. Three novel anthraquinone glucuronides were obtained, with purpurin-O-glucuronide showing significantly improved water solubility, antioxidant activity, and antibacterial bioactivity. Comparative transcript analysis revealed that glucose and sucrose utilization were significantly upregulated as DM cultivated under CCR condition, which strongly enhance the biosynthetic pathway of the precursors Uridine diphosphate glucuronic acid (UDPGA). Meanwhile, the carbon metabolic flux has significantly enhanced the fatty acid biosynthesis, the exhaust of acetyl coenzyme A may lead to the complete repression of the biosynthesis of DNR, Additionally, the efflux transporter genes were simultaneously downregulated, which may contribute to the anthraquinones intracellular glucuronidation. Overall, our findings demonstrate that utilizing CCR can be a valuable strategy for enhancing the biotransformation efficiency of anthraquinone O-glucuronides by DM. This approach has the potential to improve the bioavailability and therapeutic potential of these compounds, opening up new possibilities for their pharmaceutical applications.

Abstract Glioblastoma multiforme (GBM) is recognized as the prevailing malignant and aggressive primary brain tumor, characterized by an exceedingly unfavorable prognosis. Cuproptosis, a recently identified form of programmed cell death, exhibits a strong association with cancer progression, therapeutic response, and prognostic outcomes. However, the specific impact of cuproptosis on GBM remains uncertain. To address this knowledge gap, we obtained transcriptional and clinical data pertaining to GBM tissues and their corresponding normal samples from various datasets, including TCGA, CGGA, GEO, and GTEx. R software was utilized for the analysis of various statistical techniques, including survival analysis, cluster analysis, Cox regression, Lasso regression, gene enrichment analysis, drug sensitivity analysis, and immune microenvironment analysis. Multiple assays were conducted to investigate the expression of genes related to cuproptosis and their impact on the proliferation, invasion, and migration of glioblastoma multiforme (GBM) cells. The datasets were obtained and prognostic risk score models were constructed and validated using differentially expressed genes (DEGs) associated with cuproptosis. To enhance the practicality of these models, a nomogram was developed.Patients with glioblastoma multiforme (GBM) who were classified as high risk exhibited a more unfavorable prognosis and shorter overall survival compared to those in the low risk group. Additionally, we specifically chose FDX1 from the differentially expressed genes (DEGs) within the high risk group to assess its expression, prognostic value, biological functionality, drug responsiveness, and immune cell infiltration. The findings demonstrated that FDX1 was significantly upregulated and associated with a poorer prognosis in GBM. Furthermore, its elevated expression appeared to be linked to various metabolic processes and the susceptibility to chemotherapy drugs. Moreover, FDX1 was found to be involved in immune cell infiltration and exhibited correlations with multiple immunosuppressive genes, including TGFBR1 and PDCD1LG2. The aforementioned studies offer substantial assistance in informing the chemotherapy and immunotherapy approaches for GBM. In summary, these findings contribute to a deeper comprehension of cuproptosis and offer novel perspectives on the involvement of cuproptosis-related genes in GBM, thereby presenting a promising therapeutic strategy for GBM patients.

The effects of ScCO2 on pore structure should be investigated in order to properly apply supercritical carbon dioxide (ScCO2) fracturing on tight sandstone. ScCO2 treatment was applied to three sets of tight sandstone samples. The pore structure was characterized using a combination of high-pressure mercury intrusion porosimetry and nuclear magnetic resonance. Furthermore, the pore size distribution’s multi-fractal dimensions were estimated. After SCCO2 treatment, the number of transitional pores decreased significantly, while the number of mesopores and macropores increased. At all scales, the fractal dimension characteristics indicate that pore structure gets more complicated and heterogeneous. Furthermore, due to their larger contact area, large pores have a higher fractal dimension than small pores. The accumulative pore volume of the calcite-rich group increases and a decreasing trend occurs for the calcite-rare group. The content of calcite sharply decreased while clay, feldspar, and plagioclase content have a slight drop after ScCO2 treatment, which affects the alternation of pore structure. Thus, the accumulative porosity volume and pore connectivity do not always increase after ScCO2 exposure because re-precipitation and fine migration can potentially clog pores and channels.

Abstract Few studies have discussed the disease nature and treatment outcomes for bilateral cavernous sinus dural arteriovenous fistula (CSDAVF). This study aimed to investigate the clinical features and treatment outcomes of bilateral CSDAVF. Embase, Medline, and Cochrane library were searched for studies that specified the outcomes of bilateral CSDAVF from inception to April 2022. The classification, clinical presentation, angiographic feature, surgical approach, and treatment outcomes were collected. Meta-analysis was performed using the random effects model. Eight studies reporting 97 patients were included. The clinical presentation was mainly orbital (n = 80), cavernous (n = 52) and cerebral (n = 5) symptoms. The most approached surgical route was inferior petrosal sinus (n = 80), followed by superior orbital vein (n = 10), and alternative approach (n = 7). Clinical symptoms of 88% of the patients (95% CI 80–93%, I2 = 0%) were cured, and 82% (95% CI 70–90%, I2 = 7%) had angiographic complete obliteration of fistulas during follow up. The overall complication rate was 18% (95% CI 11–27%, I2 = 0%). Therefore, endovascular treatment is an effective treatment for bilateral CSDAVF regarding clinical or angiographic outcomes. However, detailed evaluation of preoperative images and comprehensive surgical planning of the approach route are mandatory owing to complexity of the lesions.

Abstract Background Whether diet has beneficial effects on cardiovascular disease (CVD) in childhood cancer survivors as in the general population is unknown. Therefore, we examined associations between dietary patterns and risk of CVD in adult survivors of childhood cancer. Methods Childhood cancer survivors, 18–65 years old in the St Jude Lifetime Cohort (1882 men and 1634 women) were included in the analysis. Dietary patterns were defined by the adherence to the Healthy Eating Index (HEI)–2015, Dietary Approaches to Stop Hypertension (DASH), and alternate Mediterranean diet (aMED) based on a food frequency questionnaire at study entry. CVD cases (323 in men and 213 in women) were defined as participants with at least one grade 2 or higher CVD-related diagnosis at baseline. Multivariable logistic regression adjusted for confounders was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of CVD. Results Greater adherence to HEI-2015 (OR=0.88, 95% CI: 0.75–1.03, per 10 score increment), DASH (OR=0.85, 95% CI: 0.71–1.01, per 10 score increment), and aMED (OR=0.92, 95% CI: 0.84–1.00, each score increment) were, albeit trending towards significance, associated with a lower risk of CVD in women. HEI-2015 was associated with a non-significantly lower risk of CVD in men (ORQ5 vs. Q1=0.80, 95% CI: 0.50–1.28). These dietary patterns were also associated with a lower risk of CVD in survivors with high underlying CVD risk. Conclusions As recommended to the general population, a diet rich in plant foods and moderate in animal foods needs to be a part of CVD management and prevention in childhood cancer survivors.

Salinized lacustrine shale (SLS) represents a frontier in the global quest for unconventional hydrocarbon resources. The impact of terrigenous input, which includes terrigenous organic matter (OM) and detrital matter, on the deposition and hydrocarbon potential of SLS is still controversial. Here, we examine this issue using the newly discovered SLS within the Paleogene Biyang Depression, employing a combination of organic petrographic and geochemical analyses. A high influx of terrigenous input (terrigenous OM and detrital matter) promotes the formation of SLS. On the one hand, terrigenous higher plants emerge as the primary source of OM in the SLS, as indicated by the dominance of terrigenous macerals (e.g., terrigenous liptinite) and the abundance of plant-derived biomarkers (e.g., tricyclic terpanes). Additionally, a portion of the OM may originate from bacteria. On the other hand, the rapid input of detrital matter improves the preservation of OM, resulting in the deposition of SLS with high total organic carbon (TOC) contents and low hydrogen index (HI) values. The findings of this study contribute to a deeper understanding of SLS deposition and provide guidance for regional hydrocarbon exploration.

After the initial impoundment of the Baihetan Reservoir in April 2021, the water level in front of the dam rose about 200 m. The mechanical properties and effects of the bank slopes in the reservoir area changed significantly, resulting in many bank collapses. This study systematically analyzed the bank slope of the head section of the reservoir, spanning 30 km from the dam to Baihetan Bridge, through a comprehensive investigation conducted after the initial impoundment. The analysis utilized UAV flights and ground surveys to interpret the bank slope’s distribution characteristics and failure patterns. A total of 276 bank collapses were recorded, with a geohazard development density of 4.6/km. The slope gradient of 26% of the collapsed banks experienced an increase ranging from 5 to 20° after impoundment, whereas the remaining sites’ inclines remained unchanged. According to the combination of lithology and movement mode, the bank failure mode is divided into six types, which are the surface erosion type, surface collapse type, surface slide type, bedding slip type of clastic rock, toppling type of clastic rock, and cavity corrosion type of carbonate rock. It was found that the collapsed banks in the reservoir area of 85% developed in the reactivation of old landslide deposits, while 15% in the clastic and carbonate rock. This study offers guidance for the next phase of bank collapse regulations and future geohazards prevention strategies in the Baihetan Reservoir area.

In this paper, we investigate geothermal exploration and production in 189 hydrothermal projects and 42 hot dry rock projects around the world. The hydrothermal fields for a working hydrothermal system to generate electricity should have the elements of heat source, water-saturated porous or fractured reservoir, caprock, heat transfer pathway, and good heat preservation condition and geothermal power energy intensity of 10–20 MW per km2 within at least 5 km2 area in tectonically active region. The hot water or steam flow rate in this hydrothermal system is normally larger than 40 L/s with temperature of 150 °C or above. The power generated from enhanced geothermal system (EGS) in hot dry rock projects are generally less than 2 MW because the flow rate in most cases is much less than 40 L/s even with the hydraulic fractures using the modern stimulation technology learned from the oil and gas industry. The natural fracture in the subsurface is generally beneficial to the hydraulic fracturing and heat recovery in the hot dry rock. Moreover, the hydraulic fracture parameters, injection rate and well spacing, drilling strategy should be properly designed to avoid the short-circuit between injector and producer and low heat productivity. In the future, CO2 enhanced geothermal recovery associated with CO2 sequestration in the high temperature oil, gas, and geothermal fields maybe a good choice. On the other hand, both near-real-time seismic monitoring to limit the pumping rate and the closed-loop of the Eavor-Loop style system without hydraulic fracture can contribute greatly to heat recovery of hot dry rocks and mitigate the risks of the hydraulic fracturing induced earthquake. Furthermore, the hybrid solar and geothermal system performs better than the stand-alone geothermal system.

Fragaria nilgerrensis Schlechtendal ex J. Gay, a diploid wild strawberry, has many excellent characteristics such as fruit with white color and peach fragrance, and strong disease resistance. However, the lack of an efficient and stable regeneration and genetic transformation system for F. nilgerrensis has largely limited the functional studies of related genes governing excellent traits. In this study, a regeneration system for F. nilgerrensis leaf discs was developed by optimizing factors such as different hormone combinations, dark culture times and casein hydrolysate (CH) concentrations, with an average regeneration rate of 97.3% at 45 d of culture. By paraffin section observation of callus with different colors induced from the leaf disc regeneration, light yellow callus was determined to be embryogenic and the regenerative pathway was identified as indirect organogenesis. Based on this, an average transformation percentage of 8.67% was achieved by screening kanamycin concentration and referring to transformation procedures described by predecessors. PCR-positive transformants were obtained within 4−5 months by confirmation of PCR and histochemical GUS, and transgene integration was identified by transformants regeneration. The establishment of an efficient regeneration system provided a feasible platform for genetic transformation, which provided the foundation for further gene functional studies in F. nilgerrensis.

A planar wideband circularly polarized (CP) end-fire antenna is presented for millimeter-wave (mm-wave) applications. First, the antenna consists of an open-ended substrate integrated waveguide (SIW) feeding line in the middle, a pair of stacked substrates with shorted triangular patches on both upper and lower sides, and an offset parallel strip. The shorted triangular patch is viewed as a horizontally polarized electric dipole, while the open-ended SIW is equivalent to an enhanced magnetic dipole due to the stacked substrates. Wide axial ratio (AR) performance is achieved by simultaneously exciting the two dipoles with orthogonal phase supplied by the offset parallel strip. Then, working principle and parameter analysis are explained and discussed for a further understanding. Finally, a prototype is fabricated and measured to verify the design scheme, which demonstrates wide AR bandwidth performance of 38.6%, novel and efficient radiating structure, simple and compact antenna size, and easy fabrication and integration. This indicates that the proposed antenna is a promising candidate to design wideband end-fire CP antenna in the mm-wave frequency band.

Abstract Background Human epidermal growth factor receptor 2 (HER2) overexpression is an independent prognostic factor of poor prognosis and a predictor of efficacy of anti‐HER2 therapy. A limited number of patients can receive standard second‐line therapy (DS‐8201 or T‐DM1) for metastatic HER2‐positive in some parts of the world, including China, due to many factors, such as cost–benefit ratios. Case A 51‐year‐old premenopausal woman was diagnosed with HER2‐positive breast cancer. The pathological stage was ypT3N2M0 and stage IIIA. Trastuzumab targeted therapy combined with goserelin depot was started along with letrozole endocrine therapy. After eight courses of treatment, magnetic resonance imaging (MRI) examination revealed new multiple metastases in the liver, and progression disease (PD) was evaluated. Due to abnormal activation of the phosphatidylinositol 3‐kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway in the patient, treatment was changed to the mammalian target of rapamycin (mTOR) inhibitor combined with the anti‐HER‐2 agents inetetamab and paclitaxel, while partial response (PR) was evaluated after 6 cycles of treatment. As the patient was hormone receptor (HR) positive, treatment was changed to the inetetamab + rapamycin + exemestane regimen. The lesion continued to shrink and PR was evaluated for 8 cycles. The original regimen was continued, PR was evaluated after 12 courses of treatment. The abdominal MRI performed showed an increase in the volume of intrahepatic multiple metastatic tumor lesion. Efficacy was used to assess for PD and the progression‐free survival (PFS) was 317 days. Conclusion A phosphatidylinositol‐4, 5‐bisphosphate 3‐kinase catalytic subunit alpha (PIK3CA) mutation in trastuzumab‐treated metastatic HER2‐positive breast cancer female had a long PFS by treating with the mammalian target of rapamycin inhibitor in combination with the anti‐HER‐2 agent inetetamab.

Abstract This systematic review aimed to assess the methods used to classify mammographic breast parenchymal features in relation to the prediction of future breast cancer. The databases including Medline (Ovid) 1946-, Embase.com 1947-, CINAHL Plus 1937-, Scopus 1823-, Cochrane Library (including CENTRAL), and Clinicaltrials.gov were searched through October 2021 to extract published articles in English describing the relationship of parenchymal texture features with the risk of breast cancer. Twenty-eight articles published since 2016 were included in the final review. The identification of parenchymal texture features varied from using a predefined list to machine-driven identification. A reduction in the number of features chosen for subsequent analysis in relation to cancer incidence then varied across statistical approaches and machine learning methods. The variation in approach and number of features identified for inclusion in analysis precluded generating a quantitative summary or meta-analysis of the value of these features to improve predicting risk of future breast cancers. This updated overview of the state of the art revealed research gaps; based on these, we provide recommendations for future studies using parenchymal features for mammogram images to make use of accumulating image data, and external validation of prediction models that extend to 5 and 10 years to guide clinical risk management. Following these recommendations could enhance the applicability of models, helping improve risk classification and risk prediction for women to tailor screening and prevention strategies to the level of risk.

The Schmidt reaction enables nitrogen insertion across an aldehyde or ketone substrate by frequently using azide reagents. Here, the authors show a Schmidt reaction of aryldiazonium salts as a replacement of azide reagents to access skeletally diverse cyclic lactams.

In this research work, in order to solve the unadjustability of traditional noble metal absorbers to meet the complex application requirements in the actual electromagnetic environment, we designed a simple tunable absorber based on graphene with tunable Fermi level. The performance of the proposed absorber is theoretically simulated by the finite difference time domain (FDTD) method. The proposed absorber has two perfect absorption peaks with high efficiency of 99.51% and 99.548% in its working band (90–155 μm). We have performed an in-depth analysis of the causes of perfect absorption and focused on the tunability of the absorber. The absorption frequency can be adjusted by controlling the relaxation time and Fermi level of graphene, and the same purpose can be achieved by changing the refractive index (relative dielectric constant) of the medium. In addition, we also explored the influence of the change of the top structure parameters on the absorption performance. The proposed absorber has the ability to adapt to different electromagnetic environments. In general, it can be flexibly regulated in practical applications, which will provide new possibilities for the development of many fields such as detection and communication.

Abstract Aqueous zinc‐ion batteries (AZIBs) stand out among many monovalent/multivalent metal‐ion batteries as promising new energy storage devices because of their good safety, low cost, and environmental friendliness. Nevertheless, there are still many great challenges to exploring new‐type cathode materials that are suitable for Zn2+ intercalation. Vanadium‐based compounds with various structures, large layer spacing, and different oxidation states are considered suitable cathode candidates for AZIBs. Herein, the research advances in vanadium‐based compounds in recent years are systematically reviewed. The preparation methods, crystal structures, electrochemical performances, and energy storage mechanisms of vanadium‐based compounds (e.g., vanadium phosphates, vanadium oxides, vanadates, vanadium sulfides, and vanadium nitrides) are mainly introduced. Finally, the limitations and development prospects of vanadium‐based compounds are pointed out. Vanadium‐based compounds as cathode materials for AZIBs are hoped to flourish in the coming years and attract more and more researchers' attention.

Abstract The use of metal–organic frameworks (MOFs) in solid‐state electrolytes (SSEs) has been a very attractive research area that has received widespread attention in the modern world. SSEs can be divided into different types, some of which can be combined with MOFs to improve the electrochemical performance of the batteries by taking advantage of the high surface area and high porosity of MOFs. However, it also faces many serious problems and challenges. In this review, different types of SSEs are classified and the changes in these electrolytes after the addition of MOFs are described. Afterward, these SSEs with MOFs attached are introduced for different types of battery applications and the effects of these SSEs combined with MOFs on the electrochemical performance of the cells are described. Finally, some challenges faced by MOFs materials in batteries applications are presented, then some solutions to the problems and development expectations of MOFs are given.

Thin-slice methodology has provided us with abundant behavioral streams that self-reported measures would fail to capture, but traditional analytical paradigms in social and personality psychology cannot fully capture the temporal trajectories of person perception at zero acquaintance. At the same time, empirical investigations into how persons and situations jointly predict behavior enacted in situ are scarce, despite the importance of examining real-world behavior to understand any phenomenon of interest. To complement existing theoretical models and analyses, we propose the dynamic latent state-trait model blending dynamical systems theory and person perception. We present a data-driven case study using thin-slice methodology to demonstrate the model. This study provides direct empirical support for the proposed theoretical model on person perception at zero acquaintance highlighting the target, the perceiver, the situation, and time. The results of the study demonstrate that dynamical systems theory approaches can be leveraged to provide information about person perception at zero acquaintance above and beyond that of more traditional approaches. Classification code: 3040 (Social Perception & Cognition)

Abstract Background Solitary fibrous tumor (SFT) and hemangiopericytoma (HPC) are rare mesenchymal tumors in the central nervous system with a high tendency to relapse, having a significant impact on quality of life (QoL). Due to the rarity of intracranial SFT/HPC, the prognostic factors and optimal treatment remain to be elucidated. Meanwhile, quality of life in patients with intracranial SFT/HPC is seldomly concerned. Thus, we aim to survey about the quality of life and underline some aspects demanding concern in intracranial SFT/HPC treatment through summarizing our case series in recent ten years. Methods Patients with intracranial SFT/HPC who underwent surgical resection from January 2009 to June 2019 were included in the study. Clinical features, such as age, gender, and resection extent, were collected. The EuroQol Five Dimensions Questionnaire (EQ-5D) was used to assess the patients’ quality of life (QoL). Prognosis factors related to progression-free survival (PFS) and overall survival (OS) were also evaluated. Results Thirty-six patients with a mean follow-up period of 61.6 months (range 13–123 months) were included in this study. Sixteen (44.4%) patients achieved gross total resection (GTR). Fourteen patients (38.9%) with tumor progression experienced adjuvant radiotherapy (11.1%) or Gamma Knife surgery (GKS, 27.8%). According to the 2016 WHO classification, there were 6 (16.7%) grade I SFT/HPC, 11 (30.5%) grade II SFT/HPC, and 19 (52.8%) grade III SFT/HPC. The PFS and OS were 29 months (range 4–96 months) and 38 months (range 4–125 months). The median EQ5D-3 L tariff with or without progression was 0.617 (95% CI 0.470–0.756) and 0.939 (95% CI 0.772–0.977) respectively. Gross total resection (GTR, p = 0.024) and grade I SFT/HPC (p = 0.017) were significantly associated with longer PFS. In multivariate analysis, GTR (HR 0.378, 95% CI 0.154–0.927) and adjuvant therapy (HR 0.336, 95% CI 0.118–0.956) result in significantly longer PFS in patients with SFT/HPC. Conclusions Patients underwent GTR and adjuvant therapy had longer PFS. Similarly, patients with lower WHO grade had relatively longer PFS. Therefore, GTR is advocated for the treatment of SFT/HPC. And adjuvant therapy such as GKS could be an alternative treatment for patients who underwent STR or with tumor progression. Further, the QoL decreased in patients with tumor progression and metastasis, and more attention is demanded to the QoL of intracranial SFT/HPC patients.

A micro-nano pore three-dimensional visualized real-time physical simulation of natural gas charging, in-situ pore-scale computation, pore network modelling, and apparent permeability evaluation theory were used to investigate laws of gas and water flow and their distribution, and controlling factors during the gas charging process in low-permeability (tight) sandstone reservoir. By describing features of gas-water flow and distribution and their variations in the micro-nano pore system, it is found that the gas charging in the low permeability (tight) sandstone can be divided into two stages, expansion stage and stable stage. In the expansion stage, the gas flows continuously first into large-sized pores then small-sized pores, and first into centers of the pores then edges of pores; pore-throats greater than 20 μm in radius make up the major pathway for gas charging. With the increase of charging pressure, movable water in the edges of large-sized pores and in the centers of small pores is displaced out successively. Pore-throats of 20–50 μm in radius and pore-throats less than 20 μm in radius dominate the expansion of gas charging channels at different stages of charging in turn, leading to reductions in pore-throat radius, throat length and coordination number of the pathway, which is the main increase stage of gas permeability and gas saturation. Among which, pore-throats 30–50 μm in radius control the increase pattern of gas saturation. In the stable stage, gas charging pathways have expanded to the maximum, so the pathways keep stable in pore-throat radius, throat length, and coordination number, and irreducible water remains in the pore system, the gas phase is in concentrated clusters, while the water phase is in the form of dispersed thin film, and the gas saturation and gas permeability tend stable. Connected pore-throats less than 20 μm in radius control the expansion limit of the charging pathways, the formation of stable gas-water distribution, and the maximum gas saturation. The heterogeneity of connected pore-throats affects the dynamic variations of gas phase charging and gas-water distribution. It can be concluded that the pore-throat configuration and heterogeneity of the micro-nanometer pore system control the dynamic variations of the low-permeability (tight) sandstone gas charging process and gas-water distribution features.

Polymethyl methacrylate (PMMA) bone cement (PBC) is commonly used in orthopaedic surgery. However, polymerization volumetric shrinkage, exothermic injury, and low bioactivity prevent PBC from being an ideal material. The developed expandable P(MMA-AA-St) well overcomes the volumetric shrinkage of PBC. However, its biomechanical properties are unsatisfactory. Herein, graphene oxide (GO), a hydrophilic material with favourable biomechanics and osteogenic capability, was added to P(MMA-AA-St) to optimize its biomechanics and bioactivity. The GO-modified self-expandable P(MMA-AA-St)-GO nanocomposite (PGBCs) exhibited outstanding compressive strength (>70 ​MPa), water absorption, and volume expansion, as well as a longer handling time and a reduced setting temperature. The cytocompatibility of PGBCs was superior to that of PBC, as demonstrated by CCK-8 assay, live-dead cell staining, and flow cytometry. In addition, better osteoblast attachment was observed, which could be attributed to the effects of GO. The improved level of osteogenic gene and protein expression further illustrated the improved cell-material interactions between osteoblasts and PGBCs. The results of an in vivo study performed by filling bone defects in the femoral condyles of rabbits with PGBCs demonstrated promising intraoperative handling properties and convenient implantation. Blood testing and histological staining demonstrated satisfactory in vivo biosafety. Furthermore, bone morphological and microarchitecture analyses using bone tissue staining and micro-CT scanning revealed better bone-PGBCs contact and osteogenic capability. The results of this study indicate that GO modification improved the physiochemical properties, cytocompatibility, and osteogenic capability of P(MMA-AA-St) and overcame the drawbacks of PBC, allowing its material derivatives to serve as effective implantable biomaterials.

Microscopic pore structures are of great significance in evaluating shale gas reservoirs and understanding the occurrence state of shale gas. Integrating geochemical analysis, X-ray diffraction (XRD), low-temperature N2 adsorption (LTNA), mercury injection pressure (MIP), small-angle X-ray scattering (SAXS), and field emission scanning electron microscope (FE-SEM), this work systematically characterized microscopic pore structures and then discussed their controlling factors, for the Lower Carboniferous Luzhai (C1lz) shale in Guizhong Depression. The results show that pores in the Luzhai shale are generally shaped by ink bottles, parallel plates, and slits, which are characterized by a larger pore throat ratio, lower efficiency of mercury withdrawal, and poor connectivity. Micropores (

BackgroundImmunotherapy for lung cancer has been a hot research area for years. This bibliometric analysis was intended to present research trends on melanoma immunotherapy.MethodOn April 1, 2022, the authors identified 2,109 papers on melanoma immunotherapy using the Web of Science and extracted their general information and the total number of citations. The authors then conducted a bibliometric analysis to present the research landscape, clarify the research trends, and determine the most cited papers (top-papers) as well as major journals on melanoma immunotherapy. Subsequently, recent research hotspots were identified by analyzing the latest articles in major journals.ResultsThe total and median number of citations of these 2,109 papers on melanoma immunotherapy was 137,686 and 11, respectively. “Improved survival with ipilimumab in patients with metastatic melanoma” by Hodi et al. was the most cited paper (9,824 citations). Among the journals, the top-paper number (16), average citations per paper (2,510.7), and top-papers rate (100%) of New England Journal of Medicine were the highest. Corresponding authors represented the USA took part in most articles (784). Since 2016, the hottest research area has changed from CTLA-4 to PD-1.ConclusionsThis bibliometric analysis comprehensively and quantitatively presents the research trends and hotspots based on 2,109 relevant publications, and further suggests future research directions. The researchers can benefit in selecting journals and in finding potential collaborators. This study can help researchers gain a comprehensive impression of the research landscape, historical development, and current hotspots in melanoma immunotherapy and can provide inspiration for future research.

Abstract Tumors modify myeloid cell differentiation and induce an immunosuppressive microenvironment. Granulocytic myeloid-derived suppressor cells (G-MDSCs), the main subgroup of myeloid-derived suppressor cells (MDSCs), are immature myeloid cells (IMCs) with immunosuppressive activity and exist in tumor-bearing hosts. The reason why these cells diverge from a normal differentiation pathway and are shaped into immunosuppressive cells remains unclear. Here, we reported that the increase of granulocyte colony-stimulating factor (G-CSF) in mouse serum with tumor progression encouraged G-MDSCs to obtain immunosuppressive traits in peripheral blood through the PI3K-Akt/mTOR pathway. Importantly, we found that downregulation of type I interferon (IFN-I) signaling in G-MDSCs was a prerequisite for their immunosuppressive effects. Suppressor of cytokine signaling (SOCS1), the action of which is dependent on IFN-I signaling, inhibited the activation of the PI3K-Akt/mTOR pathway by directly interacting with Akt, indicating that the differentiation of immunosuppressive G-MDSCs involves a transition from immune activation to immune tolerance. Our study suggests that increasing IFN-I signaling in G-MDSCs may be a strategy for reprograming immunosuppressive myelopoiesis and slowing tumor progression.

The strawberry species Fragaria nilgerrensis Schlechtendal ex J. Gay, renowned for its distinctive white, fragrant peach-like fruits and strong disease resistance, is an exceptional research material. In a previous study, an ethyl methane sulfonate (EMS) mutant library was established for this species, resulting in various yellow leaf mutants. Leaf yellowing materials are not only the ideal materials for basic studies on photosynthesis mechanism, chloroplast development, and molecular regulation of various pigments, but also have important utilization value in ornamental plants breeding. The present study focused on four distinct yellow leaf mutants: mottled yellow leaf (MO), yellow green leaf (YG), light green leaf (LG), and buddha light leaf (BU). The results revealed that the flavonoid content and carotenoid-to-chlorophyll ratio exhibited a significant increase among these mutants, while experiencing a significant decrease in chlorophyll and carotenoid contents compared to the wild type (WT). To clarify the regulatory mechanisms and network relationships underlying these mutants, the RNA-seq and weighted gene coexpression network (WGCNA) analyses were employed. The results showed flavonoid metabolism pathway was enriched both in MO and YG mutants, while the chlorophyll biosynthesis pathway and carotenoid degradation pathway were only enriched in MO and YG mutants, respectively. Subsequently, key structural genes and transcription factors were identified on metabolic pathways of three pigments through correlation analyses and quantitative experiments. Furthermore, a R2R3-MYB transcription factor, FnMYB4, was confirmed to be positively correlated with flavonoid synthesis through transient overexpression, virus-induced gene silencing (VIGS), and RNA interference (RNAi), accompanying by reoccurrence and attenuation of mutant phenotype. Finally, dual-luciferase (LUC) and yeast one-hybrid assays confirmed the binding of FnMYB4 to the FnFLS and FnF3H promoters, indicating that FnMYB4 positively regulates flavonoid synthesis. In addition, correlation analyses suggested that FnMYB4 also might be involved in chlorophyll and carotenoid metabolisms. These findings demonstrated the pivotal regulatory role of FnMYB4 in strawberry leaf coloration. [ABSTRACT FROM AUTHOR]

Gossypol, a phenolic compound found in the cotton plant, is widely distributed in cottonseed by-products. Although ruminant animals are believed to be more tolerant of gossypol toxicity than monogastric animals due to rumen microbial fermentation, the actual mechanisms of detoxification remain unclear. In contrast, the metabolic detoxification of gossypol by Helicoverpa armigera (Lepidoptera: Noctuidae) larvae has achieved great advances. The present review discusses the clinical signs of gossypol in ruminant animals, as well as summarizing advances in the study of gossypol detoxification in the rumen. It also examines the regulatory roles of several key enzymes in gossypol detoxification and transformation known in H. armigera. With the rapid development of modern molecular biotechnology and -omics technology strategies, evidence increasingly indicates that research into the biological degradation of gossypol in H. armigera larvae and some microbes, in terms of these key enzymes, could provide scientific insights that would underpin future work on microbial gossypol detoxification in the rumen, with the ultimate aim of further alleviating gossypol toxicity in ruminant animals.

ObjectiveMyocardial fibrosis leads to systolic dysfunction in hypertrophic cardiomyopathy (HCM) patients. This study aims to investigate the relationship between cardiac magnetic resonance mechanical parameters for evaluating the left ventricular function in HCM with preserved left ventricular ejection fraction (LVEF ≥50%) and the association between myocardial fibrosis defined by late gadolinium enhancement (LGE).MethodsThis study was a retrospective analysis of CMR images of 93 patients with HCM with preserved ejection fraction (HCMpEF) and 96 controls diagnosed by cardiac magnetic resonance (CMR) at our hospital from July 2019 to January 2022. The myocardial contraction fraction (MCF) was calculated, and myocardial mechanical parameters, including global myocardial longitudinal strain (GLS), circumferential strain (GLS), and myocardial strain (GLS), were obtained by tissue tracking and LGE quantitative modules of dedicated software, respectively. The correlation between myocardial strain and LGE was analyzed, and a multivariate logistic regression model was developed to discuss the risk predictors of LGE.ResultsCompared to the control group, the left ventricular mechanical parameters GLS (−13.90 ± 3.80% versus −18.20 ± 2.10%, p < 0.001), GCS (−16.62 ± 3.50% versus −18.4 ± 2.69%, p < 0.001), GRS (28.99 ± 10.38% versus 33.02 ± 6.25%, p < 0.01), and MCF (64 ± 16% versus 99 ± 18%, p < 0.001) were found significantly lower in HCM group. Moreover, even in LGE-negative HCM patients, GLS (−16.3 ± 3.9%) and MCF (78 ± 19%) were significantly lower compared to the control group. Left ventricular GLS [OR = 1.61, (1.29, 2.02), p = 0.001] and MCF [OR = 0.90, (0.86, 0.94), p = 0.001] independently predicted myocardial late gadolinium enhancement (LGE).ConclusionIn participants of HCM with preserved ejection fraction, the early onset of reduced left ventricular GLS and MCF in patients with HCMpEF may provide new evidence for evaluating impaired myocardial systolic function. The reduction of myocardial mechanical indexes may reflect the presence and extent of myocardial fibrosis, and the more significant the reduction, the more severe the myocardial fibrosis; GLS and MCF may be ideal predictors for LGE.

AbstractThe existence and content of water will certainly affect the effective pore space of shales and therefore is a key point for the evaluation of in-situ gas content and gas flow capacity of shale reservoirs. In order to reasonably evaluate the gas storage and flow capacities of water-bearing shale reservoirs, the effect of water on the effective pore space of shales needs to be understood. In this study, the Upper Permian Longtan shale in the southeastern Sichuan Basin, China, was selected as an example to conduct nuclear magnetic resonance cryoporometry (NMRC) measurements under different water saturation levels. The gas-accessible effective pore spaces in shales under different water saturation levels were quantified, and the effect of water saturation on gas-accessible effective pore space in shales was investigated. The results show that water plays an important role in the gas-accessible effective pore space of shales. When the Longtan shale increases from a dry state to a water saturation of 65%, 75%, and 90%, the gas-accessible effective pore volume decreases by 35%-60% (average 46.3%), 50%-70% (average 58.8%), and 65%-82% (average 75.8%), respectively. Water has an effect on the gas-accessible effective pore space regardless of pore size, and the effect is the strongest in the 4-100 nm range, which may be mainly due to the high content of clay minerals in the Longtan shale. Our studies are of important theoretical significance and application prospects for accurately evaluating the gas-accessible effective pore space of gas shales under actual geological conditions.

​BackgroundImmunotherapy for lung cancer has been a hot research area for years. This bibliometric analysis aims to present the research trends on lung cancer immunotherapy.MethodOn 1 July, 2022, the authors identified 2,941 papers on lung cancer immunotherapy by the Web of Science and extracted their general information and the total number of citations. A bibliometric analysis was carried out to present the research landscape, demonstrate the research trends, and determine the most cited papers (top papers) as well as major journals on lung cancer immunotherapy. After that, recent research hotspots were analyzed based on the latest publications in major journals.ResultsThese 2,941 papers were cited a total of 122,467 times. “Nivolumab vs. docetaxel in advanced non–squamous non–small–cell lung cancer” published in 2015 by Borghaei H et al. was the most cited paper (5,854 citations). Among the journals, New England Journal of Medicine was most influential. Corresponding authors represented China took part in most articles (904) and papers with corresponding authors from the USA were most cited (139.46 citations per paper). Since 2015, anti–PD–(L)1 has become the hottest research area.ConclusionsThis bibliometric analysis comprehensively and quantitatively presents the research trends and hotspots based on thousands of publications, and further suggests future research directions. Moreover, the results can benefit researchers to select journals and find potential collaborators. This study can help researchers get a comprehensive impression of the research landscape, historical development, and recent hotspots in lung cancer immunotherapy and provide inspiration for further research.

Backgroundradiotherapy is one of the major treatments for lung cancer and has been a hot research area for years. This bibliometric analysis aims to present the research trends on lung cancer radiotherapy.MethodOn August 31, 2022, the authors identified 9868 articles on lung cancer radiotherapy by the Web of Science (Science Citation Indexing Expanded database) and extracted their general information and the total number of citations. A bibliometric analysis was carried out to present the research landscape, demonstrate the research trends, and determine the most cited papers (top-papers) as well as top-journals on lung cancer radiotherapy. After that, the authors analyzed the recent research hotspots based on the latest publications in top-journals.ResultsThese 9868 papers were cited a total of 268,068 times. “Durvalumab after chemoradiotherapy in stage III non–small-cell lung cancer” published in 2017 by Antonia et al.was the most cited article (2110 citations). Among the journals, New England Journal of Medicine was most influential. Moreover, J. Clin. Oncol. and Int. J. Radiat. Oncol. Biol. Phys. was both influential and productive. Corresponding authors represented the USA (2610 articles) and China mainland (2060 articles) took part in most publications and articles with corresponding authors from Netherlands were most cited (46.12 citations per paper). Chemoradiotherapy was the hottest research area, and stereotactic body radiotherapy has become a research hotspot since 2006. Radiotherapy plus immunotherapy has been highly focused since 2019.ConclusionsThis bibliometric analysis comprehensively and quantitatively presents the research trends and hotspots based on 9868 relevant articles, and further suggests future research directions. The researchers can benefit in selecting journals and in finding potential collaborators. This study can help researchers gain a comprehensive picture of the research landscape, historical development, and recent hotspots in lung cancer radiotherapy and can provide inspiration for future research.

Introduction: The herbal preparation HemoHIM, which is a mixture of traditional Korean medicinal plants, has been proven effective in enhancing exercise performance and reducing fatigue levels in mice. Therefore, this study aimed to evaluate the effect of HemoHIM on fatigue levels and exercise performance in healthy human adults. Methods: Ninety-six adults with fatigue were recruited for this study. In visit 1, maximal oxygen consumption was measured using a cycle ergometer test to assess eligibility. Participants were randomly assigned to the HemoHIM group (HG, n = 48) or the placebo group (PG, n = 48) in visit 2. Each participant consumed HemoHIM or a placebo twice per day for 8 weeks and visited the laboratory four times. Body composition, vital signs, dietary intake, fatigue level (fatigue severity scale, [FSS]), cardiorespiratory endurance, muscle strength, blood biomarkers, and adverse events were measured at each visit. Results: HemoHIM significantly decreased the FSS scores compared to that of the PG at visit 3 (P=.019); this decrease was maintained until visit 4 (P=.002). The exercise distance to exhaustion in the HG significantly increased compared to that in the PG (P=.040). HemoHIM significantly increased lactate and creatinine levels immediately after the ergometer test (lactate P=.011, creatinine P=.019) and 30 min after the test (lactate P=.036, creatinine P=.002) compared to that in the PG. Conclusion: This study demonstrated that HemoHIM reduced fatigue levels and improved exercise duration. The findings may have potential applications in the nutritional supplement industry in the future. Trial registration: This study was registered at the Clinical Research Information Service: KCT0004905.

ObjectivesThis study aimed to determine whether texture analysis (TA) and machine learning-based classifications can be applied in differential diagnosis of cardiac amyloidosis (CA) and hypertrophic cardiomyopathy (HCM) using non-contrast cine cardiac magnetic resonance (CMR) images.MethodsIn this institutional review board-approved study, we consecutively enrolled 167 patients with CA (n = 85), HCM (n = 82), and 84 patients with normal CMR served as controls. All cases were randomized into training [119 patients (70%)] and validation [48 patients (30%)] groups. A total of 275 texture features were extracted from cine images. Based on regression analysis with the least absolute shrinkage and selection operator (LASSO), nine machine learning models were established and their diagnostic performance determined.ResultsNineteen radiomics texture features derived from cine images were used to differentiate CA and HCM. In the validation cohort, the support vector machine (SVM), which had an accuracy of 0.85, showed the best performance (MCC = 0.637). Gray level non-uniformity (GLevNonU) was the single most effective feature. The combined model of radiomics texture features and conventional MR metrics had superior discriminatory performance (AUC = 0.89) over conventional MR metrics model (AUC = 0.79). Moreover, results showed that GLevNonU levels in HCM patients were significantly higher compared with levels in CA patients and control groups (P < 0.001). A cut-off of GLevNonU ≥ 25 was shown to differentiate between CA and HCM patients, with an area under the curve (AUC) of 0.86 (CI:0.804–0.920). Multiple comparisons tests showed that GLevNonU was significantly greater in LGE+, relative to LGE-patient groups (CA+ vs. CA- and HCM+ vs. HCM-, P = 0.01, 0.001, respectively).ConclusionMachine learning-based classifiers can accurately differentiate between CA and HCM on non-contrast cine images. The radiomics-MR combined model can be used to improve the discriminatory performance. TA may be used to assess myocardial microstructure changes that occur during different stages of cardiomyopathies.