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1. Values and preferences towards the use of prophylactic low-molecular-weight heparin during pregnancy: a convergent mixed-methods secondary analysis of data from the decision analysis in shared decision making for thromboprophylaxis during pregnancy (DASH-TOP) study

Author

León‑García, Montserrat, Humphries, Brittany, Xie, Feng, Gravholt, Derek L., Golembiewski, Elizabeth, Eckman, Mark H., Bates, Shannon M., Hargraves, Ian, Pelayo, Irene, López, Sandra Redondo, Caño, Juan Antonio Millón, Alcántara, Milagros A. Suito, D’Souza, Rohan, Shehata, Nadine, Jack, Susan M., Guyatt, Gordon, Perestelo‑Perez, Lilisbeth, and Alonso‑Coello, Pablo

Published
2024
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4. Use of Intravenous Albumin: A Guideline From the International Collaboration for Transfusion Medicine Guidelines

Author

Flores, Jerome, Frappier, Stéfanie, Hou, Yvette, Jean-Pierre, Lilly, Jomaa, Danny, Kabir, Monisha, Kadota, Leo, Lam, Michelle, Ripsman, David A., Sandarage, Ryan, Staykov, Emiliyan, Venes, Angelica, Wan, Melissa, Al Riyami, Arwa, Allard, Shubha, Brouwers, Melissa, Callum, Jeannie, Daly, James, Denomme, Gregory A., Estcourt, Lise, Fergusson, Dean, Fung, Mark, Green, Laura, Greinacher, Andreas, Hume, Heather, Jug, Rachel, Kaufman, Richard, Kim, Hyungsuk, Louw, Vernon, Matsushita, Tadashi, Murphy, Michael, Pink, Joanne, Robinson, Susan, So-Osman, Cynthia, Stanworth, Simon, Szczepiorkowski, Zbigniew M., Tobian, Aaron, Wood, Erica, Skubas, Nikolaos J., Bathla, Aarti, Keshavarz, Homa, Clark, Edward G., Rochwerg, Bram, Arbous, Sesmu, Bauer, Seth R., China, Louise, Neill, Michael, Paine, Cary, Pavenski, Katerina, Shah, Prakesh S., Shan, Hua, Thevenot, Thierry, Wu, Bovey, and Shehata, Nadine

Published
2024
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7. Diagnosis and management of pyruvate kinase deficiency: international expert guidelines

Author

Al-Samkari, Hanny, Shehata, Nadine, Lang-Robertson, Kelly, Bianchi, Paola, Glenthøj, Andreas, Sheth, Sujit, Neufeld, Ellis J, Rees, David C, Chonat, Satheesh, Kuo, Kevin H M, Rothman, Jennifer A, Barcellini, Wilma, van Beers, Eduard J, Pospíšilová, Dagmar, Shah, Ami J, van Wijk, Richard, Glader, Bertil, Mañú Pereira, Maria Del Mar, Andres, Oliver, Kalfa, Theodosia A, Eber, Stefan W, Gallagher, Patrick G, Kwiatkowski, Janet L, Galacteros, Frédéric, Lander, Carl, Watson, Alejandra, Elbard, Riyad, Peereboom, Dore, and Grace, Rachael F

Published
2024
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12. Methemoglobin as a marker of acute anemic stress in cardiac surgery

Author

Mistry, Nikhil, Hare, Gregory M.T., Shehata, Nadine, Kramer, Robert S., Fawzy, Hosam F., Baker, Robert A., Carmona, Paula, Saczkowski, Richard, Filipescu, Daniela, Alphonsus, Christella S., Rochon, Antoine, Gregory, Alexander J., Khanykin, Boris, Leff, Jonathan D., Mateo, Eva, Karangelis, Dimos, Tellez, Juan C., Saha, Tarit, Ko, Dennis T., Wijeysundera, Duminda N., Verma, Subodh, and Mazer, C. David

Published
2023
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15. Correlation of the Transfusion Camp knowledge assessment test with clinical transfusion practice.

Author

Tordon, Bryan, Meirovich, Harley, Malkin, Amie, Pavenski, Katerina, Moorehead, Amy, Ginsborg, Lette, Saeed, Samia, Shehata, Nadine, Callum, Jeannie, Cserti‐Gazdewich, Christine, Lieberman, Lani, Pendergrast, Jacob, and Lin, Yulia

Abstract

Background: It is uncertain how transfusion knowledge translates to practice. The purpose of the study was to determine if higher scores on a validated Transfusion Camp knowledge assessment test were associated with transfusion order appropriateness. Study Design and Methods: Eligible participants included postgraduate trainees and faculty physicians who had prescribed at least four transfusion orders in the preceding 6 months at two hospitals. Participant data and knowledge were collected using a web‐based questionnaire with a validated Transfusion Camp knowledge assessment tool. The most recent 4–10 consecutive transfusion orders per prescriber were independently dually adjudicated for appropriateness based on published criteria. The primary outcome was the correlation between the score on six questions on red blood cells (RBCs), platelets (PLTs), and plasma from the validated test and the percentage order appropriateness. Generalized linear regression was conducted to determine if factors (sex, specialty, participation in Transfusion Camp, previous transfusion education, self‐rated knowledge) were associated with appropriate orders. Results: Seventy‐four participants (45 trainees, 29 faculty; 31 females, 43 males) completed the test. Median score was 66.7% (interquartile range [IQR]: 50.0, 83.3) for six questions on RBCs, PLTs, and plasma transfusions. Of 546 transfusion orders adjudicated, appropriateness was 90.7% (95% confidence interval [CI]: 87.9%–93.0%). The correlation between prescriber test scores and order appropriateness was very weak (r = −.08). In multivariable analysis, female prescribers (p =.02) and beginner (vs. intermediate) self‐rated knowledge (p =.01) were associated with higher transfusion appropriateness. Conclusion: Transfusion knowledge test scores did not correlate with order appropriateness. Factors other than knowledge are key to understanding how to improve appropriate blood use. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Author

Bégin, Philippe, Callum, Jeannie, Jamula, Erin, Cook, Richard, Heddle, Nancy M., Tinmouth, Alan, Zeller, Michelle P., Beaudoin-Bussières, Guillaume, Amorim, Luiz, Bazin, Renée, Loftsgard, Kent Cadogan, Carl, Richard, Chassé, Michaël, Cushing, Melissa M., Daneman, Nick, Devine, Dana V., Dumaresq, Jeannot, Fergusson, Dean A., Gabe, Caroline, Glesby, Marshall J., Li, Na, Liu, Yang, McGeer, Allison, Robitaille, Nancy, Sachais, Bruce S., Scales, Damon C., Schwartz, Lisa, Shehata, Nadine, Turgeon, Alexis F., Wood, Heidi, Zarychanski, Ryan, Finzi, Andrés, and Arnold, Donald M.

Published
2021
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20. Fetal/neonatal alloimmune thrombocytopenia: a systematic review of impact of HLA-DRB3*01:01 on fetal/neonatal outcome

Author

Kjeldsen-Kragh, Jens, Fergusson, Dean A., Kjaer, Mette, Lieberman, Lani, Greinacher, Andreas, Murphy, Michael F., Bussel, James, Bakchoul, Tamam, Corke, Stacy, Bertrand, Gérald, Oepkes, Dick, Baker, Jillian M., Hume, Heather, Massey, Edwin, Kaplan, Cecile, Arnold, Donald M., Baidya, Shoma, Ryan, Greg, Savoia, Helen F., Landry, Denise, and Shehata, Nadine

Published
2020
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22. Convalescent plasma for adults with acute COVID-19 respiratory illness (CONCOR-1): study protocol for an international, multicentre, randomized, open-label trial

Author

Bégin, Philippe, Callum, Jeannie, Heddle, Nancy M., Cook, Richard, Zeller, Michelle P., Tinmouth, Alan, Fergusson, Dean A., Cushing, Melissa M., Glesby, Marshall J., Chassé, Michaël, Devine, Dana V., Robitalle, Nancy, Bazin, Renée, Shehata, Nadine, Finzi, Andrés, McGeer, Allison, Scales, Damon C., Schwartz, Lisa, Turgeon, Alexis F., Zarychanski, Ryan, Daneman, Nick, Carl, Richard, Amorim, Luiz, Gabe, Caroline, Ellis, Martin, Sachais, Bruce S., Loftsgard, Kent Cadogan, Jamula, Erin, Carruthers, Julie, Duncan, Joanne, Lucier, Kayla, Li, Na, Liu, Yang, Armali, Chantal, Kron, Amie, Modi, Dimpy, Auclair, Marie-Christine, Cerro, Sabrina, Avram, Meda, and Arnold, Donald M.

Published
2021
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25. Transfusion Requirements in Cardiac Surgery III (TRICS III): Study Design of a Randomized Controlled Trial

Author

Shehata, Nadine, Whitlock, Richard, Fergusson, Dean A., Thorpe, Kevin E., MacAdams, Charlie, Grocott, Hilary P., Rubens, Fraser, Fremes, Stephen, Lellouche, Francois, Bagshaw, Sean, Royse, Alistair, Rosseel, Peter M., Hare, Greg, Medicis, Etienne De, Hudson, Christopher, Belley-Cote, Emilie, Bainbridge, Daniel, Kent, Blaine, Shaw, Andrew, Byrne, Kelly, Syed, Summer, Royse, Colin F., McGuiness, Shay, Hall, Judith, and Mazer, C. David

Published
2018
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27. Postnatal intervention for the treatment of FNAIT: a systematic review

Author

Baker, Jillian M., Shehata, Nadine, Bussel, James, Murphy, Michael F., Greinacher, Andreas, Bakchoul, Tamam, Massey, Edwin, Lieberman, Lani, Landry, Denise, Tanael, Susano, Arnold, Donald M., Baidya, Shoma, Bertrand, Gerald, Kjaer, Mette, Kaplan, Cécile, Kjeldsen-Kragh, Jens, Oepkes, Dick, Savoia, Helen, Ryan, Greg, Hume, Heather, and on behalf of the International Collaboration for Transfusion Medicine Guidelines (ICTMG)

Published
2019
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29. Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Author

Bégin, Philippe, Callum, Jeannie, Jamula, Erin, Cook, Richard, Heddle, Nancy M., Tinmouth, Alan, Zeller, Michelle P., Beaudoin-Bussières, Guillaume, Amorim, Luiz, Bazin, Renée, Loftsgard, Kent Cadogan, Carl, Richard, Chassé, Michaël, Cushing, Melissa M., Daneman, Nick, Devine, Dana V., Dumaresq, Jeannot, Fergusson, Dean A., Gabe, Caroline, Glesby, Marshall J., Li, Na, Liu, Yang, McGeer, Allison, Robitaille, Nancy, Sachais, Bruce S., Scales, Damon C., Schwartz, Lisa, Shehata, Nadine, Turgeon, Alexis F., Wood, Heidi, Zarychanski, Ryan, Finzi, Andrés, and Arnold, Donald M.

Published
2022
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31. How do we achieve blinding in modern electronic and paper medical records during the conduct of transfusion trials?

Author

Santos, Sean, Gupta, Akash, Tinmouth, Alan, Butt, Amir, Berry, Brian, Musuka, Charles, Cserti‐Gazdewich, Christine, Leung, Elaine, Duncan, Jennifer, Mack, Johnathan, Yan, Matthew T. S., Bahmanyar, Mohammad, Shehata, Nadine, Prokopchuk‐Gauk, Oksana, Onell, Rodrigo, Nahirniak, Susan, Covello, Thomas, Lin, Yulia, Solh, Ziad, and Callum, Jeannie

Subjects
ELECTRONIC health records, ELECTRONIC records, BLOOD transfusion, ELECTRONIC paper, PRODUCT coding, BLOOD platelet transfusion
Abstract

Background: Regulatory aspects of transfusion medicine add complexity in blinded transfusion trials when considering various electronic record keeping software and blood administration processes. The aim of this study is to explore strategies when blinding transfusion components and products in paper and electronic medical records. Methods: Surveys were collected and interviews were conducted for 18 sites across various jurisdictions in North America to determine solutions applied in previous transfusion randomized control trials. Results: Sixteen responses were collected of which 11 had previously participated in a transfusion randomized control trial. Various solutions were reported which were specific to the laboratory information system (LIS) and electronic medical record (EMR) combinations although solutions could be grouped into four categories which included the creation of a study product code in the LIS, preventing the transmission of data from the LIS to the EMR, utilizing specialized stickers and labels to conceal product containers and documents in the paper records, and modified bedside procedures and documentation. Discussion: LIS and EMR combinations varied across sites, so it was not possible to determine combination‐specific solutions. The study was able to highlight solutions that may be emphasized in future iterations of LIS and EMR software as well as procedural changes that may minimize the risk of unblinding. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Blood pressure thresholds for the diagnosis of hypertensive disorders of pregnancy in sickle cell disease.

Author

Early, Macy L., Raja, Maidah, Luo, Amy, Solow, Marissa, Matusiak, Kristine, Eke, Ahizechukwu C., Shehata, Nadine, Kuo, Kevin H. M., Lanzkron, Sophie, Malinowski, Ann Kinga, and Pecker, Lydia H.

Subjects
SICKLE cell anemia, SYSTOLIC blood pressure, BLOOD pressure, PREGNANT women, DIASTOLIC blood pressure, HYPERTENSION
Abstract

Summary: In this retrospective cohort study of singleton pregnancies in people with sickle cell disease (SCD) delivered at two academic centres between 1990 and 2021, we collected demographic and SCD‐related data, pregnancy outcomes, and the highest systolic and diastolic blood pressure (SBP and DBP) at seven time periods. We compared the characteristics of subjects with new or worsening proteinuria (NWP) during pregnancy to those without. We then constructed receiver operating characteristic (ROC) curves to determine the blood pressure (BP) that best identifies those with NWP. The SBP or DBP thresholds which maximized sensitivity and specificity were 120 mmHg SBP (sensitivity: 55.2%, specificity: 73.5%) and 70 mmHg DBP (sensitivity: 27.6%, specificity: 67.7%). The existing BP threshold of 140/90 mmHg lacked sensitivity in both genotype groups (HbSS/HbSβ0: SBP = 21% sensitive, DBP = 5.3% sensitive; HbSS/HbSβ+: SBP = 10% sensitive, DBP = 0% sensitive). Finally, percent change in SBP, DBP and MAP were all poor tests for identifying NWP. Existing BP thresholds used to diagnose hypertensive disorders of pregnancy (HDP) are not sensitive for pregnant people with SCD. For this population, lowering the BP threshold that defines HDP may improve identification of those who need increased observation, consideration of early delivery and eclampsia prophylaxis. [ABSTRACT FROM AUTHOR]

Published
2024
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33. The selection and preparation of red cell components for intrauterine transfusion: A national survey.

Author

Bodnar, Melanie, Lieberman, Lani, Arsenault, Valerie, Berardi, Philip, Duncan, Jennifer, Lane, Debra, Lavoie, Marianne, McCarthy, Joanna, Morrison, Douglas, Robitaille, Nancy, Shehata, Nadine, Wilson, Ann, and Clarke, Gwen

Subjects
ERYTHROCYTES, CELL anatomy, HOSPITAL laboratories, BLOOD banks, FETAL death
Abstract

Background and Objectives: The practice regarding the selection and preparation of red blood cells (RBCs) for intrauterine transfusion (IUT) is variable reflecting historical practice and expert opinion rather than evidence‐based recommendations. The aim of this survey was to assess Canadian hospital blood bank practice with respect to red cell IUT. Materials and Methods: A survey was sent to nine hospital laboratories known to perform red cell IUT. Questions regarding component selection, processing, foetal pre‐transfusion testing, transfusion administration, documentation and traceability were assessed. Results: The median annual number of IUTs performed in Canada was 109 (interquartile range, 103–118). RBC selection criteria included allogeneic, Cytomegalovirus seronegative, irradiated, fresh units with most sites preferentially providing HbS negative, group O, RhD negative, Kell negative and units lacking the corresponding maternal antibody without extended matching to the maternal phenotype. Red cell processing varied with respect to target haematocrit, use of saline reconstitution (n = 4), use of an automated procedure for red cell concentration (n = 1) and incorporation of a wash step (n = 2). Foetal pre‐transfusion testing uniformly included haemoglobin measurement, but additional serologic testing varied. A variety of strategies were used to link the IUT event to the neonate post‐delivery, including the creation of a unique foetal blood bank identifier at three sites. Conclusion: This survey reviews current practice and highlights the need for standardized national guidelines regarding the selection and preparation of RBCs for IUT. This study has prompted a re‐examination of priorities for RBC selection for IUT and highlighted strategies for transfusion traceability in this unique setting. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Natural history of blood pressure in sickle cell disease pregnancy.

Author

Early, Macy L., Luo, Amy, Solow, Marissa, Matusiak, Kristine, Eke, Ahizechukwu C., Shehata, Nadine, August, Phyllis, Kuo, Kevin H. M., Lanzkron, Sophie, Malinowski, Ann Kinga, and Pecker, Lydia H.

Subjects
SICKLE cell anemia, BLOOD pressure, PREGNANT women, DIASTOLIC blood pressure, SYSTOLIC blood pressure
Abstract

Summary: In this retrospective cohort study of singleton pregnancies in people with sickle cell disease (SCD) delivered at two academic centres between 1990 and 2021, we collected demographic and SCD‐related data, pregnancy outcomes, and the highest systolic and diastolic blood pressure (SBP and DBP) at seven time periods. We compared blood pressure values and trajectories in the composite cohort and in each genotype group to control values in a non‐SCD pregnancy dataset. There were 290 pregnancies among 197 patients with SCD. Sixteen per cent (n = 47) of pregnancies had a hypertensive disorder of pregnancy (HDP); the rates did not differ by genotype. The mean SBP and DBP were lower in the HbSS/HbSβ0 group than in the non‐SCD control group at all timepoints. Mean SBP and DBP trajectories were similar between the HbSS/HbSβ0 group and non‐SCD controls, whereas the mean SBP and DBP in the HbSC/HbSβ+ group decreased between the first and second trimesters and plateaued between the second and third trimesters. There were no differences in blood pressure trajectory by haemoglobin >/< 10 gm/dL or by chronic transfusion status. Overall, pregnant people with SCD have lower blood pressure than unaffected pregnant people, raising the possibility that HDP are underdiagnosed, particularly in people with HbSS/HbSβ0. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Effect of Empagliflozin on Erythropoietin Levels, Iron Stores, and Red Blood Cell Morphology in Patients With Type 2 Diabetes Mellitus and Coronary Artery Disease

Author

Mazer, C. David, Hare, Gregory M.T., Connelly, Philip W., Gilbert, Richard E., Shehata, Nadine, Quan, Adrian, Teoh, Hwee, Leiter, Lawrence A., Zinman, Bernard, Jüni, Peter, Zuo, Fei, Mistry, Nikhil, Thorpe, Kevin E., Goldenberg, Ronald M., Yan, Andrew T., Connelly, Kim A., and Verma, Subodh

Published
2020
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47. Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery

Author

Mazer, David C., Whitlock, Richard P., Fergusson, Dean A., Hall, Judith, Belley-Cote, Emilie, Connolly, Katherine, Khanykin, Boris, Gregory, Alexander J., de Médicis, Étienne, McGuinness, Shay, Royse, Alistair, Carrier, François M., Young, Paul J., Villar, Juan C., Grocott, Hilary P., Seeberger, Manfred D., Fremes, Stephen, Lellouche, François, Syed, Summer, Byrne, Kelly, Bagshaw, Sean M., Hwang, Nian C., Mehta, Chirag, Painter, Thomas W., Royse, Colin, Verma, Subodh, Hare, Gregory M.T., Cohen, Ashley, Thorpe, Kevin E., Jüni, Peter, and Shehata, Nadine

Published
2017
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