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9. Ubiquitin specific peptidase 37 and PCNA interaction promotes osteosarcoma pathogenesis by modulating replication fork progression

Author

Chauhan, Ravi, Gupta, Ashna, Malhotra, Lakshay, Bhat, Ajaz A., Pandita, Raj K., Masoodi, Tariq, Dagar, Gunjan, Sadida, Hana Q., Al-Marzooqi, Sara K., Batra, Atul, Bakhshi, Sameer, Sharma, Mehar Chand, Tanwar, Pranay, Khan, Shah Alam, Samath, Ethayathulla Abdul, Uddin, Shahab, Akil, Ammira S. Al-Shabeeb, Haris, Mohammad, Macha, Muzafar A., Pandita, Tej K., and Singh, Mayank

Published
2023
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19. Utility of Simple and Non-Invasive Strategies Alternative to Inferior Petrosal Sinus Sampling and Peripheral CRH Stimulation in Differential Diagnosis of ACTH-Dependent Cushing Syndrome.

Author

Attri, Bhawna, Goyal, Alpesh, Kalaivani, Mani, Kandasamy, Devasenathipathy, Gupta, Yashdeep, Agarwal, Shipra, Shamim, Shamim A., Damle, Nishikant, Sharma, Mehar Chand, Jyotsna, Viveka P., Suri, Ashish, and Tandon, Nikhil

Subjects
CUSHING'S syndrome, DIFFERENTIAL diagnosis, ADRENOCORTICOTROPIC hormone, HYPOKALEMIA, HYDROCORTISONE, ADENOMATOUS polyps
Abstract

We aimed to evaluate the utility of simple, cost-effective, and non-invasive strategies alternative to BIPSS and peripheral CRH stimulation in differential diagnosis of ACTH-dependent CS. First, we performed ROC analysis to evaluate the performance of various tests for differential diagnosis of ACTH-dependent CS in our cohort (CD, n=76 and EAS, n=23) and derived their optimal cut-offs. Subsequently, combining various demographic (gender), clinical (hypokalemia), biochemical (plasma ACTH, HDDST, peripheral CRH stimulation) and imaging (MRI pituitary) parameters, we derived non-invasive models with 100% PPV for CD. Patients with pituitary macroadenoma (n=14) were excluded from the analysis involving non-invasive models. Relative percent ACTH (AUC: 0.933) and cortisol (AUC: 0.975) increase on peripheral CRH stimulation demonstrated excellent accuracy in discriminating CD from EAS. Best cut-offs for CD were plasma ACTH<97.3 pg/ml, HDDST≥57% cortisol suppression, CRH stimulation≥77% ACTH increase and≥11% cortisol increase. We derived six models that provided 100% PPV for CD and precluded the need for BIPPS in 35/85 (41.2%) patients with ACTH-dependent CS and no macroadenoma (in whom BIPSS would have otherwise been recommended). The first three models included basic parameters and avoided both peripheral CRH stimulation and BIPSS in 19 (22.4%) patients, while the next three models included peripheral CRH stimulation and avoided BIPSS in another 16 (18.8%) patients. Using simple and non-invasive alternative strategies, BIPSS can be avoided in 41% and peripheral CRH stimulation in 22% of patients with ACTH-dependent CS and no macroadenoma; such patients can be directly referred for a pituitary surgery. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Malignancy arising in adamantinomatous craniopharyngioma: Report of a rare case with unusual morphologic features.

Author

Das, Sumanta, Sharma, Mehar Chand, Suri, Vaishali, Sahu, Saumya, Garg, Ajay, and Laythalling, Rajinder Kumar

Subjects
*ADENOID cystic carcinoma, *SQUAMOUS cell carcinoma, *CRANIOPHARYNGIOMA, *CENTRAL nervous system, *TUMOR grading
Abstract

Adamantinomatous craniopharyngioma is a grade 1 tumor that arises in a sellar/suprasellar location. Despite being a grade 1 tumor, there is high recurrence and endocrinal insufficiency. Malignancy arising in craniopharyngioma is extremely rare, has a dismal prognosis, and is currently not included as a separate entity in the World Health Organization Classification of Central Nervous System 5th edition. Here we describe a case of adamantinomatous craniopharyngioma and its malignant counterpart. The malignant part had unique histomorphology and basaloid cells with pseudoglandular architecture and a myxoid background. It bore a striking resemblance to adenoid cystic carcinoma. Both the benign and malignant counterparts were beta‐catenin and SOX‐2 positive, providing proof of the malignant part arising from the benign part. Tumors like squamous cell carcinoma and odontogenic ghost cell carcinoma have been described in cranipharyngioma. This case study is the first to describe this unique morphology of adenoid cystic carcinoma‐like features. The possibility of adenoid cystic carcinoma was excluded by immunohistochemistry. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Spinal astroblastoma, MN1 altered in 3‐year‐old child: An uncommon tumor at an unusual site.

Author

Panda, Arun Kumar, Das, Sumanta, Singh, Anuj, Vaishya, Sandeep, Gupta, Rakesh Kumar, Sharma, Mehar Chand, and Ahlawat, Sunita

Subjects
FLUORESCENCE in situ hybridization, CEREBRAL hemispheres, TUMORS in children, EPENDYMOMA, MENINGIOMA
Abstract

Astroblastoma is an uncommon circumscribed glial tumor mostly involving the cerebral hemisphere. The characteristic molecular alteration is meningioma (disrupted in balanced translocation) 1 (MN1) rearrangement. No definite World Health Organization grade has been assigned as both low‐ and high‐grade tumors are known to occur. Tumors in the spine are extremely rare; to date only three cases have been reported in the literature. A vigilant microscopy and ancillary testing aid in diagnosis when the tumors present in unusual locations, as in our case. The prompt differentiation of this tumor from its mimickers is a mandate as modalities of management are different and not clearly established. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Comparative contribution of magnetoencephalography (MEG) and single-photon emission computed tomography (SPECT) in pre-operative localization for epilepsy surgery: A prospective blinded study

Author

Kaur, Kirandeep, Garg, Ajay, Tripathi, Madhavi, Chandra, Sarat P., Singh, Gaurav, Viswanathan, Vibhin, Bharti, Kamal, Singh, Vivek, Ramanujam, Bhargavi, Bal, Chandra Sekhar, Sharma, Mehar Chand, Pandey, Ravindra, Vibha, Deepti, Singh, Rajesh Kumar, Mandal, Pravat Kumar, and Tripathi, Manjari

Published
2021
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26. Combining ability effects and nature of gene action for grain yield and quality parameters in Pop corn (Zea mays var. everta)

Author

Goutam Rana, Preeti Sharma, Mehar Chand Kamboj and Narender Singh

Subjects
combining ability, gene effects, yield component traits, line x tester, Plant culture, SB1-1110
Abstract

The proficiency and efficacy of the parental selection programmes in most of the crops including popcorn can be significantly improved by estimating the combining ability and its effects. The present study was planned with an aim to assess the combining ability variances and effects in 28 cross combinations developed by crossing eight inbred lines of popcorn in half diallel fashion design (without reciprocals). The thirty eight genotypes including twenty eight hybrids along with their eight parents and two checks were evaluated in randomized complete block design to estimate the GCA and SCA of parents as well as crosses. Results for combining ability shown that mean sum of squares due to hybrids and parents vs. hybrids were significant, which in turn exhibits significant genotypic differences for all the characters under study except grain protein content. It was also apparent that both general combining ability and specific combining ability variances were significant for all the characters except grain protein content which indicated importance of both additive and non additive gene action in the inheritance of these traits. The inbred lines viz., HKI PC 1473-5, HKI PCBT 3, HKI PC 4B were found as good combiners and desirable for both grain yield and quality traits with high popping expansion. The cross combination HKI PC 1473-5 x HKI PCBT 3, HKI PC 4 x HKI PC 7 and HKI PC 4B x HKI PCBT 3 showed good SCA effects for grain yield, yield related traits and quality traits and thus indicated non additive gene effects is more pronounced and selection may prove reliable in maize hybridization programme for improvement of yield and other characters.

Published
2020
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30. Altered expression of activating transcription factor 3 in the hippocampus of patients with mesial temporal lobe epilepsy-hippocampal sclerosis (MTLE-HS).

Author

Paul, Debasmita, Dixit, Aparna Banerjee, Srivastava, Arpna, Banerjee, Jyotirmoy, Tripathi, Manjari, Suman, Priya, Doddamani, Ramesh, Lalwani, Sanjeev, Siraj, Fouzia, Sharma, Mehar Chand, Chandra, P. Sarat, and Singh, Rajesh Kumar

Subjects
HIPPOCAMPAL sclerosis, TRANSFORMING growth factors-beta, PROTEIN expression, TRANSCRIPTION factors, HIPPOCAMPUS (Brain)
Abstract

Aim of the study: Activating Transforming factor 3 (ATF3) is a stress induced gene and closely associated with neuro-inflammation while Transforming growth Factor Beta (TGFβ) signalling is also reported to be involved in neuro-inflammation and hyper-excitability associated with drug resistant epilepsy. Animal model studies indicate the involvement of ATF3 and TGFβ receptors to promote epileptogenesis. Human studies also show that TGFβ signalling is activated in MTLE-HS. However, lack of studies on ATF3 and TGFβRI expression in MTLE-HS patients exists. We hypothesize that ATF3 and TGFβRI might be expressed in hippocampi of patients with MTLE-HS and playing role in epileptogenesis. Materials & methods: Protein expression of ATF3 and TGFβRI was performed by western blotting. Localisation of ATF3 was performed by immunohistochemistry and immunoflorescence. Results: Protein expression of ATF3 and TGFβRI was significantly up-regulated in hippocampi of patients as compared to controls. Also ATF3 IR was significantly expressed in hippocampi of patients and ATF3 was expressed predominantly in cytoplasm as compared to nucleus. No correlation was found between ATF3 expression and epilepsy duration and seizure frequency. Conclusions: ATF3 and TGFβRI are both important players in neuro-inflammation and might potentiate epileptogenesis in these patients. [ABSTRACT FROM AUTHOR]

Published
2024
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39. A prospective phase II trial of response adapted whole brain radiotherapy after high dose methotrexate based chemotherapy in patients with newly diagnosed primary central nervous system lymphoma-analysis of acute toxicity profile and early clinical outcome

Author

Adhikari, Narayan, Biswas, Ahitagni, Gogia, Ajay, Sahoo, Ranjit Kumar, Garg, Ajay, Nehra, Ashima, Sharma, Mehar Chand, Bhasker, Suman, Singh, Manmohan, Sreenivas, Vishnubhatla, Chawla, Rohan, Joshi, Garima, Kumar, Lalit, and Chander, Subhash

Published
2018
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45. C11orf95-RELA, YAP1-MAMLD1, and YAP1-FAM118B Fusion Negative Anaplastic Ependymoma with Lipogenic Differentiation.

Author

Jha, Shilpy, Mulgulwar, Prit Benny, Sharma, Mehar Chand, Purkait, Suvendu, Pattnaik, Ashis, and Sable, Mukund Namdev

Subjects
EPENDYMOMA, CENTRAL nervous system cancer, CHIMERIC proteins
Abstract

Lipogenic differentiation in ependymoma is an infrequent occurrence with very few reported cases. The grading was done solely based on the histomorphology and molecular subtyping was not described in such ependymomas. New molecular classification divided ependymomas in nine different subgroups, of which supratentorial location tumor usually exhibits C11orf95-RELA, YAP1-MAMLD1, and YAP1-FAM118B fusion proteins. A 46-year-old female presented with headache and right-sided parapresis. Radilogy revealed a large intraxial left parietooccipital mass lesion, which histologically and immuohistochemically confirmed as anaplastic ependymoma with extensive lipogenic changes. The ependymal origin of the tumor was corroborated by the immunohistochemistry and ultrastructural studies. Molecular studies for C11orf95-RELA, YAP1-MAMLD1, and YAP1-FAM118B fusion proteins were negative. This is the first documentation of fusion negative supratentorial anaplastic ependymoma with lipogenic differentiation. This novel finding needs further reinforcement by similar studies to identify its impact on the disease outcome. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Metastatic alveolar soft part sarcoma of the kidney in a young female.

Author

Kumar, Shritosh, Nayak, Brusabhanu, Bharati, Vandna, Kaushal, Seema, and Sharma, Mehar Chand

Subjects
ULTRASONIC imaging of the abdomen, IMMUNOCHEMISTRY, NEPHRECTOMY, BACKACHE, METASTASIS, POSITRON emission tomography computed tomography, CANCER relapse, LUNG tumors, DIAGNOSTIC imaging, KIDNEY tumors, EDEMA, SARCOMA, SUNITINIB, RARE diseases, PELVIS
Abstract

A 19-year-old female presented with left flank discomfort and swelling. Imaging revealed a large mass arising from the left kidney, and radical nephrectomy confirmed the diagnosis of alveolar soft part sarcoma (ASPS) based on histopathological and ultrastructural examination. Postoperatively, positron emission tomography-computerized tomography showed lung metastasis and renal bed recurrence. Sunitinib was initiated for metastatic ASPS. This case underscores challenges in diagnosing and managing ASPS, highlighting the role of tyrosine kinase inhibitors. Multidisciplinary care and vigilant follow-up are crucial for rare tumors such as ASPS. [ABSTRACT FROM AUTHOR]

Published
2024
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