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537 results on '"Seliger, Stephen"'

7. Assessment of Biomarkers of Myocardial injury, Inflammation, and Renal Function in Heart Failure With Reduced Ejection Fraction: The VICTORIA Biomarker Substudy

Author

DEFILIPPI, CHRISTOPHER R., ALEMAYEHU, WENDIMAGEGN G., VOORS, ADRIAAN A., KAYE, DAVID, BLAUSTEIN, ROBERT O., BUTLER, JAVED, EZEKOWITZ, JUSTIN A., HERNANDEZ, ADRIAN F., LAM, CAROLYN S.P., ROESSIG, LOTHAR, SELIGER, STEPHEN, SHAH, PALAK, WESTERHOUT, CYNTHIA M., ARMSTRONG, PAUL W., and O'CONNOR, CHRISTOPHER M.

Published
2023
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13. Ten-Year Risk-Prediction Equations for Incident Heart Failure Hospitalizations in Chronic Kidney Disease: Findings from the Chronic Renal Insufficiency Cohort Study and the Multi-Ethnic Study of Atherosclerosis

Author

Mehta, Rupal, Ning, Hongyan, Bansal, Nisha, Cohen, Jordana, Srivastava, Anand, Dobre, Mirela, Michos, Erin D., Rahman, Mahboob, Townsend, Raymond, Seliger, Stephen, Lash, James P., Isakova, Tamara, Lloyd-Jones, Donald M., and Khan, Sadiya S.

Published
2022
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14. Upper Reference Limits for High-Sensitivity Cardiac Troponin T and N-Terminal Fragment of the Prohormone Brain Natriuretic Peptide in Patients With CKD

Author

Appel, Lawrence J., Feldman, Harold I., Lash, James P., Nelson, Robert G., Rao, Panduranga S., Rahman, Mahboob, Shah, Vallabh O., Townsend, Raymond R., Unruh, Mark L., Bansal, Nisha, Zelnick, Leila R., Ballantyne, Christie M., Chaves, Paulo H.M., Christenson, Robert H., Coresh, Josef, deFilippi, Christopher R., de Lemos, James A., Daniels, Lori B., Go, Alan S., He, Jiang, Hedayati, S. Susan, Matsushita, Kunihiro, Nambi, Vijay, Shlipak, Michael G., Taliercio, Jonathan J., and Seliger, Stephen L.

Published
2022
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20. Association Between Kidney Clearance of Secretory Solutes and Cardiovascular Events: The Chronic Renal Insufficiency Cohort (CRIC) Study

Author

Appel, Lawrence J., He, Jiang, Rao, Panduranga S., Rahman, Mahboob, Townsend, Raymond R., Chen, Yan, Zelnick, Leila R., Huber, Matthew P., Wang, Ke, Bansal, Nisha, Hoofnagle, Andrew N., Paranji, Rajan K., Heckbert, Susan R., Weiss, Noel S., Go, Alan S., Hsu, Chi-yuan, Feldman, Harold I., Waikar, Sushrut S., Mehta, Rupal C., Srivastava, Anand, Seliger, Stephen L., Lash, James P., Porter, Anna C., Raj, Dominic S., and Kestenbaum, Bryan R.

Published
2021
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22. Change in Cardiac Biomarkers and Risk of Incident Heart Failure and Atrial Fibrillation in CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study

Author

Appel, Lawrence J., Rao, Panduranga S., Rahman, Mahboob, Townsend, Raymond R., Bansal, Nisha, Zelnick, Leila R., Soliman, Elsayed Z., Anderson, Amanda, Christenson, Robert, DeFilippi, Christopher, Deo, Rajat, Feldman, Harold I., He, Jiang, Ky, Bonnie, Kusek, John, Lash, James, Seliger, Stephen, Shafi, Tariq, Wolf, Myles, Go, Alan S., and Shlipak, Michael G.

Published
2021
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24. Associations Between Cardiac Biomarkers and Cardiac Structure and Function in CKD

Author

Appel, Lawrence J., Feldman, Harold I., Go, Alan S., He, Jiang, Kusek, John W., Lash, James P., Rao, Panduranga S., Rahman, Mahboob, Townsend, Raymond R., Stein, Nathan R., Zelnick, Leila R., Anderson, Amanda H., Christenson, Robert H., deFilippi, Christopher R., Deo, Rajat, Ky, Bonnie, Seliger, Stephen L., Soliman, Elsayed Z., Shlipak, Michael G., and Bansal, Nisha

Published
2020
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25. Establishing Core Cardiovascular Outcome Measures for Trials in Hemodialysis: Report of an International Consensus Workshop

Author

Craig, Jonathan C., Tong, Allison, Manns, Braden, Pecoits-Filho, Roberto, Harris, Tess, Wheeler, David C., Winkelmayer, Wolfgang, Levin, Adeera, O'Lone, Emma, Herrington, William G., Herzog, Chuck A., Rocco, Michael V., Strippoli, Giovanni, Jardine, Meg, Kleinpeter, Myra, Ju, Angela, Cho, Yeoungjee, Gutman, Talia, Bernier-Jean, Amelie, James, Laura, Hamiwka, Lorraine, Viecelli, Andrea K., Jardine, Alan, Bello, Amino, Stengel, Benedicte, Schiller, Brigitte, Johnson, David, Bavlovlenkov, Elena, Caskey, Fergus, Gillespie, Barbara, Block, Geoffrey, Phan, Hai An, Heerspink, Hiddo Lambers, Madero, Magdalena, Ruospo, Marinella, Unruh, Mark, Laville, Maurice, Bansal, Nisha, Mark, Patrick, Blankestijn, P.J., Roy-Chaudhury, Prabir, Perlman, Rachel, Agarwal, Rajiv, Mehrotra, Rajnish, Seliger, Stephen, Shafi, Tariq, Hiemstra, Thomas, Jassal, Vanita, Perkovic, Vlado, Simplice, Amanda, White, David, Eilers, Denise, Alexander, Herbert, Landry, Yvonne, Landry, Gennifer, Wilkie, Caroline, Sautenet, Benedicte, Herzog, Charles A., Jafar, Tazeen H., Krane, Vera, Malyszko, Jolanta, Tonelli, Marcello, Wang, Angela Yee Moon, Wanner, Christoph, Zannad, Faiez, and Winkelmayer, Wolfgang C.

Published
2020
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27. Association of Continued Use of SGLT2 Inhibitors From the Ambulatory to Inpatient Setting With Hospital Outcomes in Patients With Diabetes: A Nationwide Cohort Study.

Author

Singh, Lakshmi G., Ntelis, Spyridon, Siddiqui, Tariq, Seliger, Stephen L., Sorkin, John D., and Spanakis, Elias K.

Subjects
CANAGLIFLOZIN, SODIUM-glucose cotransporter 2 inhibitors, HOSPITAL patients, PEOPLE with diabetes, COHORT analysis, ACUTE kidney failure
Abstract

OBJECTIVE: Limited data are available on the continuation of outpatient sodium glucose cotransporter 2 inhibitors (SGLT2is) during hospitalization. The objective was to evaluate associations of SGLT2i continuation in the inpatient setting with hospital outcomes. RESEARCH DESIGN AND METHODS: This nationwide cohort study used Veterans Affairs health care system data of acute care hospitalizations between 1 April 2013 and 31 August 2021. A total of 36,505 admissions of patients with diabetes with an outpatient prescription for an SGLT2i prior to hospitalization were included. The exposure was defined as SGLT2i continuation during hospitalization. Admissions where SGLT2i was continued were compared with admissions where it was discontinued. The primary outcome was in-hospital mortality. Secondary outcomes were acute kidney injury (AKI) and length of stay (LOS). Negative binomial propensity score–weighted and zero-truncated analyses were used to compare outcomes and adjusted for multiple covariates, including demographics and comorbidities. RESULTS: Mean (SE) age was 67.2 (0.1) and 67.5 (0.1) years (P = 0.03), 97.0% and 96.6% were male (P = 0.1), 71.3% and 72.1% were White, and 20.8% and 20.5% were Black (P = 0.52) for the SGLT2i continued and discontinued groups, respectively. After adjustment for covariates (age, sex, race, BMI, Elixhauser comorbidity index, procedures/surgeries, and insulin use), the SGLT2i continued group had a 45% lower mortality rate (incidence rate ratio [IRR] 0.55, 95% CI 0.42–0.73, P < 0.01), no difference in AKI (IRR 0.96, 95% CI 0.90–1.02, P = 0.17), and decreased LOS (4.7 vs. 4.9 days) (IRR 0.95, 95% CI 0.93–0.98, P < 0.01) versus the SGLT2i discontinued group. Similar associations were observed across multiple sensitivity analyses. CONCLUSIONS: Continued SGLT2i during hospitalization among patients with diabetes was associated with lower mortality, no increased AKI, and shorter LOS. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Cognitive Impairment in Non–Dialysis-Dependent CKD and the Transition to Dialysis: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study

Author

Appel, Lawrence J., Feldman, Harold I., Go, Alan S., He, Jiang, Kusek, John W., Rao, Panduranga, Rahman, Mahboob, Harhay, Meera N., Xie, Dawei, Zhang, Xiaoming, Hsu, Chi-yuan, Vittinghoff, Eric, Sozio, Stephen M., Blumenthal, Jacob, Seliger, Stephen, Chen, Jing, Deo, Rajat, Dobre, Mirela, Akkina, Sanjeev, Reese, Peter P., Lash, James P., Yaffe, Kristine, and Kurella Tamura, Manjula

Published
2018
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29. Unique metabolomic signature associated with hepatorenal dysfunction and mortality in cirrhosis

Author

Mindikoglu, Ayse L., Opekun, Antone R., Putluri, Nagireddy, Devaraj, Sridevi, Sheikh-Hamad, David, Vierling, John M., Goss, John A., Rana, Abbas, Sood, Gagan K., Jalal, Prasun K., Inker, Lesley A., Mohney, Robert P., Tighiouart, Hocine, Christenson, Robert H., Dowling, Thomas C., Weir, Matthew R., Seliger, Stephen L., Hutson, William R., Howell, Charles D., Raufman, Jean-Pierre, Magder, Laurence S., and Coarfa, Cristian

Published
2018
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37. Incorporation of Biomarkers Into Risk Assessment for Allocation of Antihypertensive Medication According to the 2017 ACC/AHA High Blood Pressure Guideline: A Pooled Cohort Analysis

Author

Pandey, Ambarish, Patel, Kershaw V., Vongpatanasin, Wanpen, Ayers, Colby, Berry, Jarett D., Mentz, Robert J., Blaha, Michael J., McEvoy, John W., Muntner, Paul, Vaduganathan, Muthiah, Correa, Adolfo, Butler, Javed, Shimbo, Daichi, Nambi, Vijay, deFilippi, Christopher, Seliger, Stephen L., Ballantyne, Christie M., Selvin, Elizabeth, de Lemos, James A., and Joshi, Parag H.

Published
2019
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43. Retinopathy and Cognitive Impairment in Adults With CKD

Author

Yaffe, Kristine, Ackerson, Lynn, Hoang, Tina D., Go, Alan S., Maguire, Maureen G., Ying, Gui-Shuang, Daniel, Ebenezer, Bazzano, Lydia A., Coleman, Martha, Cohen, Debbie L., Kusek, John W., Ojo, Akinlolu, Seliger, Stephen, Xie, Dawei, and Grunwald, Juan E.

Published
2013
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47. Development and validation of a decision support tool for the diagnosis of acute heart failure: systematic review, meta-analysis, and modelling study

Author

Lee, Kuan Ken, Doudesis, Dimitrios, Anwar, Mohamed, Astengo, Federica, Chenevier-Gobeaux, Camille, Claessens, Yann-Erick, Wussler, Desiree, Kozhuharov, Nikola, Strebel, Ivo, Sabti, Zaid, deFilippi, Christopher, Seliger, Stephen, Moe, Gordon, Fernando, Carlos, Bayes-Genis, Antoni, van Kimmenade, Roland R. J., Pinto, Yigal, Gaggin, Hanna K., Wiemer, Jan C., Möckel, Martin, Rutten, Joost H. W., van den Meiracker, Anton H., Gargani, Luna, Pugliese, Nicola R., Pemberton, Christopher, Ibrahim, Irwani, Gegenhuber, Alfons, Mueller, Thomas, Neumaier, Michael, Behnes, Michael, Akin, Ibrahim, Bombelli, Michele, Grassi, Guido, Nazerian, Peiman, Albano, Giovanni, Bahrmann, Philipp, Newby, David E., Japp, Alan G., Tsanas, Athanasios, Shah, Anoop S. V., Richards, A. Mark, McMurray, John J. V., Mueller, Christian, Januzzi, James L., Mills, Nicholas L., on behalf of the CoDE-HF investigators, Cardiology, ACS - Heart failure & arrhythmias, Internal Medicine, Lee, K, Doudesis, D, Anwar, M, Astengo, F, Chenevier-Gobeaux, C, Claessens, Y, Wussler, D, Kozhuharov, N, Strebel, I, Sabti, Z, Defilippi, C, Seliger, S, Moe, G, Fernando, C, Bayes-Genis, A, van Kimmenade, R, Pinto, Y, Gaggin, H, Wiemer, J, Möckel, M, Rutten, J, van den Meiracker, A, Gargani, L, Pugliese, N, Pemberton, C, Ibrahim, I, Gegenhuber, A, Mueller, T, Neumaier, M, Behnes, M, Akin, I, Bombelli, M, Grassi, G, Nazerian, P, Albano, G, Bahrmann, P, Newby, D, Japp, A, Tsanas, A, Shah, A, Richards, A, Mcmurray, J, Mueller, C, Januzzi, J, and Mills, N

Subjects
Heart Failure, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Predictive Value of Test, General Medicine, Biomarker, Peptide Fragments, Diagnosis, Differential, Prospective Studie, Observational Studies as Topic, Peptide Fragment, SDG 3 - Good Health and Well-being, Predictive Value of Tests, Natriuretic Peptide, Brain, Humans, Prospective Studies, Biomarkers, Human
Abstract

ObjectivesTo evaluate the diagnostic performance of N-terminal pro-B-type natriuretic peptide (NT-proBNP) thresholds for acute heart failure and to develop and validate a decision support tool that combines NT-proBNP concentrations with clinical characteristics.DesignIndividual patient level data meta-analysis and modelling study.SettingFourteen studies from 13 countries, including randomised controlled trials and prospective observational studies.ParticipantsIndividual patient level data for 10 369 patients with suspected acute heart failure were pooled for the meta-analysis to evaluate NT-proBNP thresholds. A decision support tool (Collaboration for the Diagnosis and Evaluation of Heart Failure (CoDE-HF)) that combines NT-proBNP with clinical variables to report the probability of acute heart failure for an individual patient was developed and validated.Main outcome measureAdjudicated diagnosis of acute heart failure.ResultsOverall, 43.9% (4549/10 369) of patients had an adjudicated diagnosis of acute heart failure (73.3% (2286/3119) and 29.0% (1802/6208) in those with and without previous heart failure, respectively). The negative predictive value of the guideline recommended rule-out threshold of 300 pg/mL was 94.6% (95% confidence interval 91.9% to 96.4%); despite use of age specific rule-in thresholds, the positive predictive value varied at 61.0% (55.3% to 66.4%), 73.5% (62.3% to 82.3%), and 80.2% (70.9% to 87.1%), in patients aged 75 years, respectively. Performance varied in most subgroups, particularly patients with obesity, renal impairment, or previous heart failure. CoDE-HF was well calibrated, with excellent discrimination in patients with and without previous heart failure (area under the receiver operator curve 0.846 (0.830 to 0.862) and 0.925 (0.919 to 0.932) and Brier scores of 0.130 and 0.099, respectively). In patients without previous heart failure, the diagnostic performance was consistent across all subgroups, with 40.3% (2502/6208) identified at low probability (negative predictive value of 98.6%, 97.8% to 99.1%) and 28.0% (1737/6208) at high probability (positive predictive value of 75.0%, 65.7% to 82.5%) of having acute heart failure.ConclusionsIn an international, collaborative evaluation of the diagnostic performance of NT-proBNP, guideline recommended thresholds to diagnose acute heart failure varied substantially in important patient subgroups. The CoDE-HF decision support tool incorporating NT-proBNP as a continuous measure and other clinical variables provides a more consistent, accurate, and individualised approach.Study registrationPROSPERO CRD42019159407.

Published
2022
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