35 results on '"Sean Lang"'
Search Results
2. Impaired Atrial Function in Pediatric Pulmonary Hypertension Patients Using Cardiac MRI
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Kimberley Miles, MD, Hieu Ta, MD, Kurt Bjorkman, MD, Russel Hirsch, MD, Sean Lang, MD, Michelle Cash, Melissa Magness, RN, Meredith O'Neil, Kimberly Luebbe, RN, and Paul Critser, MD
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2024
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3. A Rare Diagnosis of an Asymptomatic Pediatric Cardiac Lipoma of the Interventricular Septum
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Stefanie Cheang and Sean Lang, MD
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2024
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4. Association of Acute Anti-inflammatory Treatment With Medium-term Outcomes for Coronary Artery Aneurysms in Kawasaki Disease
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Kevin G. Friedman, MD, Brian W. McCrindle, MD, MPH, Kyle Runeckles, MSc, Nagib Dahdah, MD, Ashraf S. Harahsheh, MD, Michael Khoury, MD, Sean Lang, MD, Cedric Manlhiot, PhD, Adriana H. Tremoulet, MD, MAS, Geetha Raghuveer, MD, Elif Seda Selamet Tierney, MD, Pei-Ni Jone, MD, Jennifer S. Li, MD, MHS, Jacqueline R. Szmuszkovicz, MD, Kambiz Norozi, MD, PhD, Supriya S. Jain, MD, Angela T. Yetman, MD, Jane W. Newburger, MD, MPH, Carolyn A. Altman, MD, Brett R. Anderson, MD, MBA, MS, Mikayla Beckley, BS, Elizabeth Braunlin, MD, PhD, Jane C. Burns, MD, Michael R. Carr, MD, Nadine F. Choueiter, MD, Jessica H. Colyer, MD, MBA, Frederic Dallaire, MD, PhD, Sarah D. De Ferranti, MD, MPH, Laurent Desjardins, MD, Matthew D. Elias, MD, Anne Ferris, MBBS, Michael Gewitz, MD, Therese M. Giglia, MD, Steven C. Greenway, MD, Kevin C. Harris, MD, MHSc, Kevin D. Hill, MD, MSc, Michelle Hite, Thomas R. Kimball, MD, Shelby Kutty, MD, Lillian Lai, MD, MHA, Simon Lee, MD, Ming-Tai Lin, MD, PhD, Tisiana Low, MD, MSc, Andrew S. Mackie, MD, MSc, Wadi Mawad, MD, Mathew, MSc, Kimberly E. McHugh, MD, Tapas Mondal, MD, Kimberly Myers, MD, Michael A. Portman, MD, Claudia Renaud, MD, Rosie Scuccimarri, MD, S. Kristen Sexson Tejitel, MD, PhD, MPH, Karen M. Texter, MD, Deepika Thacker, MD, Sharon Wagner-Lees, RN-BC, BSN, Kenny Wong, MD, Mei-Hwan Wu, MD, PhD, and Varsha Zadokar, MBBS
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: The impact of adjunctive anti-inflammatory treatment on outcomes for patients with Kawasaki disease (KD) and coronary artery aneurysms (CAAs) is unknown. Methods: Using data from the International KD Registry in patients with ≥ medium CAA we evaluate associations of treatment with outcomes and major adverse cardiac events (MACE). Results: Medium or large CAA was present in 527 (32%) patients. All were treated with intravenous immunoglobulin (IVIG), 70% were male, and the median age was 1.3 years (interquartile range: 0.4-4.0 years). The most common acute therapies included single IVIG alone in 243 (46%), multiple IVIG in 100 (19%), multiple IVIG + corticosteroids in 75 (14%), and multiple IVIG + infliximab + corticosteroids in 44 (8%) patients. Patients who received therapy beyond single IVIG had a larger CA z-score at baseline (P < 0.001) and a higher rate of bilateral CAA (P < 0.001). Compared with IVIG alone, early adjunctive treatments (within 3 days of initial IVIG) were not associated with time to CAA regression or MACE, whereas later adjunctive therapy was associated with MACE and longer time to CAA regression. Patients receiving IVIG plus steroids vs IVIG alone had a trend towards shorter time to CAA regression and lower risk of MACE (P = 0.07). A larger CAA z-score at baseline was the strongest predictor of an increase in the CAA z-score over follow-up, lower likelihood of CAA regression, and higher risk of MACE. Conclusions: Persistence of CAA and MACE are more strongly associated with baseline severity CAA than with acute adjuvant anti-inflammatory therapy. Patients who received late adjunctive therapy are at higher risk for worse outcomes. Résumé: Contexte: L’incidence d’un traitement anti-inflammatoire d’appoint chez les patients atteints de la maladie de Kawasaki (MK) compliquée d’anévrismes coronariens est inconnue. Méthodologie: À partir de données provenant du registre international de la maladie de Kawasaki portant sur les patients ayant subi des anévrismes coronariens modérés ou importants, nous avons évalué l’incidence des différents traitements sur les résultats cliniques et les événements cardiovasculaires indésirables majeurs (ECIM). Résultats: Des anévrismes coronariens modérés ou importants ont été relevés chez 527 patients (32 %). Tous les patients recevaient des immunoglobulines administrées par voie intraveineuse (IgIV); 70 % d’entre eux étaient de sexe masculin, et leur âge médian était de 1,3 an (écart interquartile : de 0,4 an à 4,0 ans). Les traitements d’urgence les plus fréquents comprenaient un seul traitement par IgIV chez 243 patients (46 %), plusieurs traitements par IgIV chez 100 patients (19 %), une association de plusieurs traitements IgIV et de corticostéroïdes chez 75 patients (14 %) et une association de plusieurs traitements IgIV, de corticostéroïdes et d’infliximab chez 44 patients (8 %). Les patients ayant reçu un traitement autre qu’un seul traitement IgIV présentaient des scores z initiaux plus élevés pour le diamètre des artères coronaires (P < 0,001) et un taux plus élevé d’anévrismes coronariens bilatéraux (P < 0,001). En comparaison d’un traitement par IgIV seulement, les traitements d’appoint précoces (administrés dans les trois jours suivant le début du traitement par IgIV) n’ont pas eu d’incidence sur la durée avant la régression des anévrismes coronariens ni sur la survenue d’ECIM, alors que les traitements d’appoint plus tardifs ont été associés à un risque plus élevé d’ECIM et à une régression plus tardive des anévrismes coronariens. Les patients ayant reçu une association d’IgIV et de corticostéroïdes avaient tendance à présenter une régression plus rapide des anévrismes coronariens et un plus faible risque d’ECIM que ceux recevant uniquement un traitement par IgIV (P = 0,07). Un score z initial plus élevé pour un anévrisme coronarien était le facteur prédictif le plus puissant d’une augmentation du score z pendant la période de suivi, d’une probabilité plus faible de régression de l’anévrisme et d’un risque plus élevé d’ECIM. Conclusions: La gravité initiale de l’anévrisme coronarien est plus fortement associée à la persistance de l’anévrisme et à la survenue d’ECIM que le recours à un traitement anti-inflammatoire d’urgence en appoint. Les patients recevant un traitement d’appoint tardif étaient par ailleurs plus susceptibles de présenter des résultats défavorables.
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- 2022
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5. Epigenetic inactivation of the autophagy–lysosomal system in appendix in Parkinson’s disease
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Juozas Gordevicius, Peipei Li, Lee L. Marshall, Bryan A. Killinger, Sean Lang, Elizabeth Ensink, Nathan C. Kuhn, Wei Cui, Nazia Maroof, Roberta Lauria, Christina Rueb, Juliane Siebourg-Polster, Pierre Maliver, Jared Lamp, Irving Vega, Fredric P. Manfredsson, Markus Britschgi, and Viviane Labrie
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Science - Abstract
Dysfunction of the gastrointestinal system, and to the autophagy lysososmal pathway (ALP) have been reported in Parkinson’s disease. Here the authors report epigenetic disruption of ALP related genes in the appendix of individuals with Parkinson’s disease.
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- 2021
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6. Hemispheric asymmetry in the human brain and in Parkinson’s disease is linked to divergent epigenetic patterns in neurons
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Peipei Li, Elizabeth Ensink, Sean Lang, Lee Marshall, Meghan Schilthuis, Jared Lamp, Irving Vega, and Viviane Labrie
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Hemisphere asymmetry ,Parkinson’s disease ,Aging ,Enhancer ,Neurons ,Epigenetics ,Biology (General) ,QH301-705.5 ,Genetics ,QH426-470 - Abstract
Abstract Background Hemispheric asymmetry in neuronal processes is a fundamental feature of the human brain and drives symptom lateralization in Parkinson’s disease (PD), but its molecular determinants are unknown. Here, we identify divergent epigenetic patterns involved in hemispheric asymmetry by profiling DNA methylation in isolated prefrontal cortex neurons from control and PD brain hemispheres. DNA methylation is fine-mapped at enhancers and promoters, genome-wide, by targeted bisulfite sequencing in two independent sample cohorts. Results We find that neurons of the human prefrontal cortex exhibit hemispheric differences in DNA methylation. Hemispheric asymmetry in neuronal DNA methylation patterns is largely mediated by differential CpH methylation, and chromatin conformation analysis finds that it targets thousands of genes. With aging, there is a loss of hemispheric asymmetry in neuronal epigenomes, such that hemispheres epigenetically converge in late life. In neurons of PD patients, hemispheric asymmetry in DNA methylation is greater than in controls and involves many PD risk genes. Epigenetic, transcriptomic, and proteomic differences between PD hemispheres correspond to the lateralization of PD symptoms, with abnormalities being most prevalent in the hemisphere matched to side of symptom predominance. Hemispheric asymmetry and symptom lateralization in PD is linked to genes affecting neurodevelopment, immune activation, and synaptic transmission. PD patients with a long disease course have greater hemispheric asymmetry in neuronal epigenomes than those with a short disease course. Conclusions Hemispheric differences in DNA methylation patterns are prevalent in neurons and may affect the progression and symptoms of PD.
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- 2020
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7. Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia
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Issaka Yougbaré, Wei-She Tai, Darko Zdravic, Brigitta Elaine Oswald, Sean Lang, Guangheng Zhu, Howard Leong-Poi, Dawei Qu, Lisa Yu, Caroline Dunk, Jianhong Zhang, John G. Sled, Stephen J. Lye, Jelena Brkić, Chun Peng, Petter Höglund, B. Anne Croy, S. Lee Adamson, Xiao-Yan Wen, Duncan J. Stewart, John Freedman, and Heyu Ni
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Science - Abstract
Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is a gestational disease caused by maternal immune responses against fetal platelets. Using a FNAIT mouse model and human trophoblast cell lines, here the authors show that uterine natural killer cell-mediated trophoblast apoptosis contributes to FNAIT pathogenesis.
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- 2017
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8. Crosstalk between Platelets and the Immune System: Old Systems with New Discoveries
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Conglei Li, June Li, Yan Li, Sean Lang, Issaka Yougbare, Guangheng Zhu, Pingguo Chen, and Heyu Ni
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Platelets are small anucleate cells circulating in the blood. It has been recognized for more than 100 years that platelet adhesion and aggregation at the site of vascular injury are critical events in hemostasis and thrombosis; however, recent studies demonstrated that, in addition to these classic roles, platelets also have important functions in inflammation and the immune response. Platelets contain many proinflammatory molecules and cytokines (e.g., P-selectin, CD40L, IL-1β, etc.), which support leukocyte trafficking, modulate immunoglobulin class switch, and germinal center formation. Platelets express several functional Toll-like receptors (TLRs), such as TLR-2, TLR-4, and TLR-9, which may potentially link innate immunity with thrombosis. Interestingly, platelets also contain multiple anti-inflammatory molecules and cytokines (e.g., transforming growth factor-β and thrombospondin-1). Emerging evidence also suggests that platelets are involved in lymphatic vessel development by directly interacting with lymphatic endothelial cells through C-type lectin-like receptor 2. Besides the active contributions of platelets to the immune system, platelets are passively targeted in several immune-mediated diseases, such as autoimmune thrombocytopenia, infection-associated thrombocytopenia, and fetal and neonatal alloimmune thrombocytopenia. These data suggest that platelets are important immune cells and may contribute to innate and adaptive immunity under both physiological and pathological conditions.
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- 2012
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9. Epigenetic inactivation of the autophagy–lysosomal system in appendix in Parkinson’s disease
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Markus Britschgi, Viviane Labrie, Irving E. Vega, Lee Marshall, Nazia Maroof, Juliane Siebourg-Polster, Nathan C. Kuhn, Peipei Li, Wei Cui, Juozas Gordevičius, Jared Lamp, Sean Lang, Fredric P. Manfredsson, Roberta Lauria, Christina Rueb, Elizabeth Ensink, Bryan A. Killinger, and Pierre Maliver
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Male ,musculoskeletal diseases ,Parkinson's disease ,Science ,General Physics and Astronomy ,Biology ,Epigenetic inactivation ,autophagy ,Appendix ,digestive system ,General Biochemistry, Genetics and Molecular Biology ,Deep sequencing ,Article ,Epigenesis, Genetic ,Mice ,Protein Aggregates ,stomatognathic system ,medicine ,Autophagy ,Animals ,Humans ,Epigenetics ,Epigenetics in the nervous system ,Gene ,Epigenesis ,Gastrointestinal tract ,Multidisciplinary ,musculoskeletal, neural, and ocular physiology ,Brain ,Parkinson Disease ,General Chemistry ,DNA Methylation ,medicine.disease ,musculoskeletal system ,Mice, Inbred C57BL ,DNA methylation ,Cancer research ,alpha-Synuclein ,Female ,Lysosomes ,Neuroscience - Abstract
The gastrointestinal tract may be a site of origin for α-synuclein pathology in idiopathic Parkinson’s disease (PD). Disruption of the autophagy-lysosome pathway (ALP) may contribute to α-synuclein aggregation. Here we examined epigenetic alterations in the ALP in the appendix by deep sequencing DNA methylation at 521 ALP genes. We identified aberrant methylation at 928 cytosines affecting 326 ALP genes in the appendix of individuals with PD and widespread hypermethylation that is also seen in the brain of individuals with PD. In mice, we find that DNA methylation changes at ALP genes induced by chronic gut inflammation are greatly exacerbated by α-synuclein pathology. DNA methylation changes at ALP genes induced by synucleinopathy are associated with the ALP abnormalities observed in the appendix of individuals with PD specifically involving lysosomal genes. Our work identifies epigenetic dysregulation of the ALP which may suggest a potential mechanism for accumulation of α-synuclein pathology in idiopathic PD., Dysfunction of the gastrointestinal system, and to the autophagy lysososmal pathway (ALP) have been reported in Parkinson’s disease. Here the authors report epigenetic disruption of ALP related genes in the appendix of individuals with Parkinson’s disease.
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- 2021
10. Changing Characteristics of Children With COVID-19 in Colorado Admitted During Different Variant Periods.
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Jelic, Monika, Silveira, Lori, Sean Lang, Curran-Hays, Shane, Boyer, Shea, Carter, Brian, Ye Ji Choi, Fresia, Joellen, Maeda, Lilia C., Nerguizian, David, Graff, Kelly, Abuogi, Lisa, and Smith, Christiana
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- 2023
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11. Density profile of 3He in a nanoscale 3He-4He superfluid film determined by neutron scattering
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Oleg Kirichek, Christopher R. Lawson, Christy J. Kinane, Andrew J. Caruana, Sean Langridge, Timothy R. Charlton, and Peter V. E. McClintock
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Astrophysics ,QB460-466 ,Physics ,QC1-999 - Abstract
Abstract For decades, superfluid helium has attracted the interest of the scientific community as an extremely pure realisation of a quantum liquid, only accessible at temperatures close to absolute zero. Previously, helium films have only been observed directly using X-rays. However, this method is limited to temperatures above 1 K due to the high levels of energy deposition, and it also suffers from an inability to distinguish between helium isotopes. Here we show that a 3He layer on top of a phase separated mixture film at 170 mK gradually dissolves into the 4He with increasing temperature. We also observe an anomaly in film behaviour near 300 mK and unexpected restoration of the layered structure at 1.5 K which is consistent with a re-entrant phase transition leading to the suppression of superfluidity in the film near 300 mK. Our successful application of neutron scattering to study helium films at ultra-low temperatures opens up new possibilities for future research.
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- 2024
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12. Bending skyrmion strings under two-dimensional thermal gradients
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Kejing Ran, Wancong Tan, Xinyu Sun, Yizhou Liu, Robert M. Dalgliesh, Nina-Juliane Steinke, Gerrit van der Laan, Sean Langridge, Thorsten Hesjedal, and Shilei Zhang
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Science - Abstract
Abstract Magnetic skyrmions are topologically protected magnetization vortices that form three-dimensional strings in chiral magnets. With the manipulation of skyrmions being key to their application in devices, the focus has been on their dynamics within the vortex plane, while the dynamical control of skyrmion strings remained uncharted territory. Here, we report the effective bending of three-dimensional skyrmion strings in the chiral magnet MnSi in orthogonal thermal gradients using small angle neutron scattering. This dynamical behavior is achieved by exploiting the temperature-dependent skyrmion Hall effect, which is unexpected in the framework of skyrmion dynamics. We thus provide experimental evidence for the existence of magnon friction, which was recently proposed to be a key ingredient for capturing skyrmion dynamics, requiring a modification of Thiele’s equation. Our work therefore suggests the existence of an extra degree of freedom for the manipulation of three-dimensional skyrmions.
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- 2024
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13. Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia
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Lisa Yu, Issaka Yougbaré, Jelena Brkić, Brigitta Elaine Oswald, Heyu Ni, Darko Zdravic, John Freedman, Howard Leong-Poi, Guangheng Zhu, S. Lee Adamson, Caroline Dunk, Jianhong Zhang, Dawei Qu, Duncan J. Stewart, Sean Lang, Chun Peng, Xiao-Yan Wen, Stephen J. Lye, John G. Sled, Petter Höglund, Wei-She Tai, and B. Anne Croy
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0301 basic medicine ,Male ,Spiral artery ,Placenta ,Science ,General Physics and Astronomy ,Intrauterine growth restriction ,Apoptosis ,Biology ,General Biochemistry, Genetics and Molecular Biology ,Article ,Miscarriage ,Cell Line ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Immune system ,Pregnancy ,medicine ,Animals ,Humans ,reproductive and urinary physiology ,Fetus ,Multidisciplinary ,Fetal Growth Retardation ,Natural Cytotoxicity Triggering Receptor 1 ,Integrin beta3 ,Trophoblast ,General Chemistry ,medicine.disease ,3. Good health ,Abortion, Spontaneous ,Killer Cells, Natural ,Thrombocytopenia, Neonatal Alloimmune ,Disease Models, Animal ,030104 developmental biology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Neonatal alloimmune thrombocytopenia ,Immunology ,embryonic structures ,Female - Abstract
Miscarriage and intrauterine growth restriction (IUGR) are devastating complications in fetal/neonatal alloimmune thrombocytopenia (FNAIT). We previously reported the mechanisms for bleeding diatheses, but it is unknown whether placental, decidual immune cells or other abnormalities at the maternal–fetal interface contribute to FNAIT. Here we show that maternal immune responses to fetal platelet antigens cause miscarriage and IUGR that are associated with vascular and immune pathologies in murine FNAIT models. Uterine natural killer (uNK) cell recruitment and survival beyond mid-gestation lead to elevated NKp46 and CD107 expression, perforin release and trophoblast apoptosis. Depletion of NK cells restores normal spiral artery remodeling and placental function, prevents miscarriage, and rescues hemorrhage in neonates. Blockade of NK activation receptors (NKp46, FcɣRIIIa) also rescues pregnancy loss. These findings shed light on uNK antibody-dependent cell-mediated cytotoxicity of invasive trophoblasts as a pathological mechanism in FNAIT, and suggest that anti-NK cell therapies may prevent immune-mediated pregnancy loss and ameliorate FNAIT., Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is a gestational disease caused by maternal immune responses against fetal platelets. Using a FNAIT mouse model and human trophoblast cell lines, here the authors show that uterine natural killer cell-mediated trophoblast apoptosis contributes to FNAIT pathogenesis.
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- 2017
14. Hypoglycemia in Hospice Patients With Type 2 Diabetes in a National Sample of Nursing Homes
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Siqi Gan, W. John Boscardin, Sean Lang-Brown, Sei J. Lee, Bocheng Jing, and Laura A. Petrillo
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Male ,medicine.medical_specialty ,endocrine system diseases ,medicine.medical_treatment ,MEDLINE ,030209 endocrinology & metabolism ,Type 2 diabetes ,Hypoglycemia ,03 medical and health sciences ,0302 clinical medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,Research Letter ,Humans ,030212 general & internal medicine ,Aged ,Retrospective Studies ,Veterans ,business.industry ,Insulin ,Incidence (epidemiology) ,Incidence ,nutritional and metabolic diseases ,Retrospective cohort study ,medicine.disease ,United States ,Nursing Homes ,Hospice Care ,Diabetes Mellitus, Type 2 ,Emergency medicine ,Female ,Nursing homes ,business - Abstract
This retrospective cohort study examines whether patients with type 2 diabetes on hospice are assessed for dysglycemia, receive insulin or oral hypoglycemic medications, or experience hypoglycemia and hyperglycemia in the nursing home setting.
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- 2017
15. PARALLELS ACROSS THE POND: WEALTH ASSOCIATED DISPARITY IN DEATH AND DISABILITY IN THE U.S. AND ENGLAND
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Cyrus Ahalt, Sean Lang-Brown, Rebecca T. Brown, Lena K. Makaroun, Sei J. Lee, L. Diaz-Ramirez, and John Boscardin
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Abstracts ,Health (social science) ,Geography ,Development economics ,Life-span and Life-course Studies ,Health Professions (miscellaneous) ,Parallels - Abstract
Low income is strongly associated with adverse health outcomes. Wealth may be a better marker of resources in late life than income. Our objective was to determine the relationship of wealth with mortality and disability (defined as activity of daily living difficulty) among older adults in the US and England. The US Health and Retirement Study (HRS) and English Longitudinal Study on Ageing (ELSA) are nationally representative cohorts of community-dwelling older adults. We examined participants enrolled in HRS (N = 13,533) and ELSA (N = 8,886) in 2002, stratifying our analyses by age (50–64 vs 66–80) as many safety-net programs commence around age 65. Wealth quintile was based on total net-worth in 2002. Participants were followed until 2012 for mortality and disability. We found increased risk of both death and disability as wealth decreased. In the US, participants age 50–64 in the lowest wealth quintile (Q1) ($553,000) had a 6% risk of mortality and 15% risk of disability. In England, 50–64 year olds in Q1 (£303,000) had a 4% risk of mortality and 11% risk of disability. In 66–80 year olds, the absolute risks of mortality and disability were higher, but the risk gradient across wealth quintiles did not differ. Low wealth was similarly associated with death and disability in both the US and England.
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- 2017
16. Web Development with Jade : Knowing Jade Makes Life Simpler and More Productive for Web Developers, and This Book Will Teach You the Language Concisely and Thoroughly Using Lots of Practical Examples and Best Practices for a Solid Grounding.
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Sean Lang and Sean Lang
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- Web site development, Jade (Computer file), Document markup languages
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Key FeaturesBook DescriptionThis is a step-by step, tutorial-based book which will enable web developers to explore the functionalities of Jade and learn how to use it to write certain functions and processes for web development. This book is for web developers with at least a basic understanding of HTML and JavaScript. It will enable you to write an easier form of language that then compiles into HTML.What you will learnWrite cleaner, indentationbased markupUse logical statements to format data for display on the WebAvoid repetition by eliminating redundant operationsDivide your templates into logical sections with blocksAvoid common organizational pitfalls when designing Jadebased projectsApply shorthand for brevityUtilize Jade for clientside templatesEmploy techniques like filters to quickly mockup web pages in higher level languages like stylus or coffeescriptWho this book is for
- Published
- 2014
17. First World War For Dummies
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Seán Lang and Seán Lang
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- World War, 1914-1918--Campaigns, World War, 1914-1918--Pictorial works, World War, 1914-1918
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From the Somme to Gallipoli to the home front, First World War For Dummies provides an authoritative, accessible, and engaging introduction to the War to End All Wars. It takes a global perspective of this global conflict, proving insight into the actions and motivations of the participants and how each nation's story fits into the wider one. Coverage also includes: The origins of the war and a snapshot of what the world looked like at the beginning of the 20th century The battles of Western Europe, and action in the Southern and Eastern Fronts The war at home — the civilian war, propaganda, opposition, politics, protests, and more 1918: The German spring offensive, the Allied success and the beginning of the end The Treaty of Versailles, the League of Nations, and the effect on the future First World War For Dummies is the go-to source for readers seeking to learn more about the fundamental event of the 20th century.
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- 2014
18. Maternal anti-platelet β3 integrins impair angiogenesis and cause intracranial hemorrhage
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Bjørn Skogen, Howard Leong-Poi, Darko Zdravic, Xiao-Yan Wen, John Freedman, Heyu Ni, S. Lee Adamson, Conglei Li, Issaka Yougbaré, Sean Lang, Pingguo Chen, Wei-She Tai, Mette Kjaer Killie, Xu Zhao, Hong Yang, Guangheng Zhu, Alexandra H. Marshall, Brian Vadasz, Siavash Piran, Shelley R. Boyd, and Heidi Tiller
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Male ,Angiogenesis ,Apoptosis ,030204 cardiovascular system & hematology ,Autoantigens ,Immunoglobulin G ,Neovascularization ,Mice ,0302 clinical medicine ,Antibody Specificity ,Pregnancy ,Medicine ,Platelet ,Maternal-Fetal Exchange ,Mice, Knockout ,0303 health sciences ,biology ,Neovascularization, Pathologic ,Integrin beta3 ,Brain ,Immunoglobulins, Intravenous ,Platelet Glycoprotein GPIb-IX Complex ,General Medicine ,Fetal Blood ,3. Good health ,Neonatal alloimmune thrombocytopenia ,Female ,medicine.symptom ,Intracranial Hemorrhages ,Research Article ,Blood Platelets ,Neovascularization, Physiologic ,03 medical and health sciences ,Human Umbilical Vein Endothelial Cells ,Animals ,Humans ,Antigens, Human Platelet ,030304 developmental biology ,Fetus ,business.industry ,Immune Sera ,Retinal Vessels ,medicine.disease ,Thrombocytopenia, Neonatal Alloimmune ,Disease Models, Animal ,Hemostasis ,Immunology ,biology.protein ,business ,Immunity, Maternally-Acquired ,Proto-Oncogene Proteins c-akt - Abstract
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a life-threatening disease in which intracranial hemorrhage (ICH) is the major risk. Although thrombocytopenia, which is caused by maternal antibodies against β3 integrin and occasionally by maternal antibodies against other platelet antigens, such as glycoprotein GPIbα, has long been assumed to be the cause of bleeding, the mechanism of ICH has not been adequately explored. Utilizing murine models of FNAIT and a high-frequency ultrasound imaging system, we found that ICH only occurred in fetuses and neonates with anti-β3 integrin-mediated, but not anti-GPIbα-mediated, FNAIT, despite similar thrombocytopenia in both groups. Only anti-β3 integrin-mediated FNAIT reduced brain and retina vessel density, impaired angiogenic signaling, and increased endothelial cell apoptosis, all of which were abrogated by maternal administration of intravenous immunoglobulin (IVIG). ICH and impairment of retinal angiogenesis were further reproduced in neonates by injection of anti-β3 integrin, but not anti-GPIbα antisera. Utilizing cultured human endothelial cells, we found that cell proliferation, network formation, and AKT phosphorylation were inhibited only by murine anti-β3 integrin antisera and human anti-HPA-1a IgG purified from mothers with FNAIT children. Our data suggest that fetal hemostasis is distinct and that impairment of angiogenesis rather than thrombocytopenia likely causes FNAIT-associated ICH. Additionally, our results indicate that maternal IVIG therapy can effectively prevent this devastating disorder.
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- 2015
19. Measurement of the Induced Magnetic Polarisation of Rotated-Domain Graphene Grown on Co Film with Polarised Neutron Reflectivity
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Razan Omar M. Aboljadayel, Christy John Kinane, Carlos Antonio Fernandes Vaz, David Michael Love, Marie-Blandine Martin, Andrea Cabrero-Vilatela, Philipp Braeuninger-Weimer, Adrian Ionescu, Andrew John Caruana, Timothy Randall Charlton, Justin Llandro, Pedro Manuel da Silva Monteiro, Crispin Henry William Barnes, Stephan Hofmann, and Sean Langridge
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graphene ,PNR ,XMCD ,magnetism ,heterostructures ,Chemistry ,QD1-999 - Abstract
In this paper, we determine the magnetic moment induced in graphene when grown on a cobalt film using polarised neutron reflectivity (PNR). A magnetic signal in the graphene was detected by X-ray magnetic circular dichroism (XMCD) spectra at the C K-edge. From the XMCD sum rules an estimated magnetic moment of 0.3 μB/C atom, while a more accurate estimation of 0.49 μB/C atom was obtained by carrying out a PNR measurement at 300 K. The results indicate that the higher magnetic moment in Co is counterbalanced by the larger lattice mismatch between the Co-C (1.6%) and the slightly longer bond length, inducing a magnetic moment in graphene that is similar to that reported in Ni/graphene heterostructures.
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- 2023
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20. European History For Dummies
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Seán Lang and Seán Lang
- Abstract
Read about the world's smallest continent's incredible history: From Greek gods and mad Roman emperors to kings, queens, Visigoths, and Normans You meet Visigoths in Africa and Normans in Sicily; an Italian who talked to his books and another who conquered a kingdom and gave it away; Roman emperors who weren't Roman; and Holy Roman Emperors who weren't holy (or Roman). This is the story of Europe's rich history rolled into one thrilling account in plain English. European History For Dummies takes you on a fascinating journey through the disasters, triumphs, people, power, and politics that have shaped the Europe we know today - and you'll meet some incredible characters along the way! From Roman relics to the Renaissance, World Wars, and Eurovision, this accessible guide packs in the facts alongside fun tidbits and brings the past alive. You meet the two Catholic kings of Spain (one was a woman) and the Spanish king who never smiled. You discover a German monk who split Europe in two because he was so afraid of going to hell. And what about the great European war that started when two nobles were thrown out of a window onto a dungheap? Well, at least they had a soft landing. If you don't remember much of what you learned about European history at school, if you didn't like those dry school textbooks, if you think European history sounds a bit hard, but you're interested anyway, this is the book for you. Inside you'll discover: The varied history of the world's smallest continent, its origins, and its huge impact on the world How the Romans shaped the ancient world, what they learned from the Greeks, and what they lost to the barbarian tribes The many battles of the Middle Ages and the leaders who waged them The medieval people's great achievements in building and learning Europeans'world explorers, including Columbus and Vasco da Gama Unfortunate religious wars and the persecution of witches Europe's world domination in the 18th and 19th centuries The world wars of the 20th century European life today Get your own copy of European History For Dummies to learn all of that and more -- including the ten Europeans who dominated the continent, ten unforgettable dates, and ten European locales you'll absolutely want to visit.
- Published
- 2011
21. British History For Dummies
- Author
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Seán Lang and Seán Lang
- Abstract
Royally confused about kings and queens? Never sure what happened when? Or where — England, Scotland, Ireland, or Wales? Learn the people and events that shaped British history British History For Dummies, 3rd Edition is full of rip-roaring stories of power-mad kings, executions, invasions, high treason, global empire building, and forbidden love — not bad for a nation of stiff upper lips. Engaged travelers, lifelong learners, history buffs, and students will all enjoy this friendly and accessible guide written in, well, plain English. This book is for you if you studied British History in school (perhaps a while ago) or learned only a bit about Wales or Scotland or Ireland and want to know more. And if you've ever asked yourself,'What kingdoms are part of the United Kingdom?'or'Exactly how was the UK formed?'or'Which people make up the UK?'— you've come to the right place, to get those answers and so much more. With an 8-page color insert so you can see who, what, and where the ensuing historical action takes place, you'll learn about the following people and events (and more): What led to the Roman invasion and about the Britons who resisted it How Britain was divided into Saxon and Celtic kingdoms How the Roman Church converted Celtic and British Christians When the Vikings arrived, and what other invaders followed The many battles of Henry II The forming of England's parliament How the Black Death affected Britain The Tudors vs. The Stuarts How the Industrial Revolution helped push advancements in farming and infrastructure All about the Victorians — everyone's favorite Britain's involvement in the Great War and World War II Additionally, this edition is revised and expanded to include the historical parliamentary elections of 2010 and the British mission in Afghanistan, and you don't want to miss out. Pick up your copy of British History For Dummies, 3rd Edition today.
- Published
- 2011
22. Crosstalk between Platelets and the Immune System: Old Systems with New Discoveries
- Author
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Sean Lang, Issaka Yougbaré, Yan-Yan Li, Guangheng Zhu, Pingguo Chen, June Li, Conglei Li, and Heyu Ni
- Subjects
0303 health sciences ,Innate immune system ,business.industry ,Germinal center ,Inflammation ,Review Article ,Hematology ,030204 cardiovascular system & hematology ,medicine.disease ,Acquired immune system ,3. Good health ,Proinflammatory cytokine ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Neonatal alloimmune thrombocytopenia ,Immunology ,medicine ,Platelet ,Diseases of the blood and blood-forming organs ,medicine.symptom ,RC633-647.5 ,business ,030304 developmental biology - Abstract
Platelets are small anucleate cells circulating in the blood. It has been recognized for more than 100 years that platelet adhesion and aggregation at the site of vascular injury are critical events in hemostasis and thrombosis; however, recent studies demonstrated that, in addition to these classic roles, platelets also have important functions in inflammation and the immune response. Platelets contain many proinflammatory molecules and cytokines (e.g., P-selectin, CD40L, IL-1β, etc.), which support leukocyte trafficking, modulate immunoglobulin class switch, and germinal center formation. Platelets express several functional Toll-like receptors (TLRs), such as TLR-2, TLR-4, and TLR-9, which may potentially link innate immunity with thrombosis. Interestingly, platelets also contain multiple anti-inflammatory molecules and cytokines (e.g., transforming growth factor-βand thrombospondin-1). Emerging evidence also suggests that platelets are involved in lymphatic vessel development by directly interacting with lymphatic endothelial cells through C-type lectin-like receptor 2. Besides the active contributions of platelets to the immune system, platelets are passively targeted in several immune-mediated diseases, such as autoimmune thrombocytopenia, infection-associated thrombocytopenia, and fetal and neonatal alloimmune thrombocytopenia. These data suggest that platelets are important immune cells and may contribute to innate and adaptive immunity under both physiological and pathological conditions.
- Published
- 2012
23. Spin-singlet to triplet Cooper pair converter interface
- Author
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Matthew Rogers, Alistair Walton, Machiel G. Flokstra, Fatma Al Ma’Mari, Rhea Stewart, Stephen L. Lee, Thomas Prokscha, Andrew J. Caruana, Christian J. Kinane, Sean Langridge, Harry Bradshaw, Timothy Moorsom, Mannan Ali, Gavin Burnell, Bryan J. Hickey, and Oscar Cespedes
- Subjects
Astrophysics ,QB460-466 ,Physics ,QC1-999 - Abstract
Magnetic molecules deposited on a metallic substrate constitute a method to engineer the spin properties of the molecule and has potential application in low-power information storage devices. Here, the authors investigate a superconductor/molecule/normal metal heterostructure and demonstrate spin-ordering and proximity induced superconducting properties at the metallo-molecular interface.
- Published
- 2021
- Full Text
- View/download PDF
24. Twentieth Century History For Dummies
- Author
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Seán Lang and Seán Lang
- Subjects
- History, Modern--20th century
- Abstract
The 20th Century brought revolutionary changes to our world and our lives: the human population of the world tripled, space travel became reality, two world wars and a host of other conflicts were fought, and huge advances in science, technology and communication resulted in the globalised world we know today. Enormous steps were made in wiping out widespread discrimination, from the women's suffrage movement leading to women's right to vote in western countries, to the civil rights movement in the US challenging racial segregation. The political landscape has provided lots of excitement, with charismatic and scandalous presidents in the White House, the first female prime minister in the UK, dictators working to various manifestoes across the world, the Middle East conflict and the changing balance of political and economic “superpowers”. Technological advances have resulted in nigh on universal adoption and dependence on automobiles, computers, mobiles and other wireless technology. The exponential rate at which technology is evolving is one of the variables that make the twentieth century so fascinating. All this and much, much more happened in a mere one hundred years – where did we find the time to do so much?! Twentieth Century History For Dummies tells all...
- Published
- 2008
25. British History For Dummies
- Author
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Seán Lang and Seán Lang
- Abstract
History is always a popular subject and British history has created some of the most lively and fascinating stories there are! Britain as we know it today has been shaped by centuries of political turmoil between state and church, as well as international conflicts, making its history a fascinating insight into how modern Britain has emerged. For this special, hardback edition of British History For Dummies, we've added over 100 black and white and colour photos for an even more explosive experience of British history. British History For Dummies Illustrated Edition: British history is still a major topic of interest, emphasised by the continual TV coverage and documentaries Inside you'll find rip-roaring stories of power-mad kings, executions, invasions, high treason, global empire-building and forbidden love- not bad for a nation of stiff upper lips! Includes fascinating information in the fun For Dummies style- from the Stone Age right through to modern day Britain and everything in between! Provides the ultimate British history experience and the hardback format with over 100 illustrations make it the perfect gift for amateur historians
- Published
- 2008
26. European History for Dummies
- Author
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Seán Lang and Seán Lang
- Subjects
- National characteristics, European
- Abstract
A fun, informative guide to Europe's past and present. The history of Europe is rich, complex, vibrant, and at times violent; it has influenced many countries throughout the world and has itself been influenced by many countries. In the light-hearted European History For Dummies, historian Sean Lang explores the countries, conflicts, people, institutions, disasters, and triumphs that have helped shape modern-day Europe, packing in tons of facts alongside the fun. Chapters range from'Celts without Kilts'and'What a Way to Run a Republic!'to'I Capture Quite a Few Castles,''Reformation Ruckus,'and'The War to End All Wars.'Sean Lang, the author of British History For Dummies (0-7645-7021-8), is also a history lecturer, examiner, and writer.
- Published
- 2006
27. British History for Dummies
- Author
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Seán Lang and Seán Lang
- Abstract
Bestseller! Now with extended coverage of modern British history Britain's past brought right up to date This book is a riotous, irreverent account of the people and events that have shaped Britain. Always get those kings and queens confused? Never sure what happened when? You need this book. Inside you'll find rip-roaring stories of power-mad kings, executions, invasions, high treason, global empire-building, and forbidden love - not bad for a nation of stiff upper lips. Praise for British History For Dummies'It puts the history of Britain into the sort of perspective I've always hoped for.'—Terry Jones, Monty Python star and co-author of Who Murdered Chaucer?'Honestly—you can't beat British History For Dummies.'—Bernard Cornwell, author of the Sharpe novels Discover how to Famous and infamous Britons Key royal, military, and cultural eras Power in Britain: Who lost it, who took it The rise and fall of Britain's global empire History as it connects to Britain today
- Published
- 2006
28. Emergent Interfacial Ferromagnetism and Exchange Bias Effect in Paramagnetic/Ferromagnetic Oxide Heterostructures
- Author
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Harsh Bhatt, Yogesh Kumar, Champa Lal Prajapat, Christy J. Kinane, Andrew Caruana, Sean Langridge, Saibal Basu, and Surendra Singh
- Subjects
emergent interfacial ferromagnetism ,exchange bias ,interfacial exchange coupling ,polarized neutron reflectometry ,Physics ,QC1-999 ,Technology - Abstract
Abstract The experimental evidence of the exchange bias (EB) effect in epitaxial heterostructures of ferromagnetic La0.67Sr0.33MnO3 (LSMO) and paramagnetic LaNiO3 (LNO) grown on MgO(001) substrates is reported. The macroscopic magnetization measurements show a clear indication of EB in LNO/LSMO and LSMO/LNO/LSMO heterostructures. The strength of the exchange coupling rapidly reduces as the temperature is increased and almost vanishes above 50 K. Using spin dependent polarized neutron reflectometry (PNR) detailed depth dependent magnetization profiles of the heterostructures are investigated to understand the role of interface magnetism in the observed EB. PNR results establish the emergence of the interfacial ferromagnetic LNO layer of thickness ≈22–35 Å (≈6–9 unit cell) and magnetization ≈80 emu cc−1 at the LNO/LSMO interface for T
- Published
- 2020
- Full Text
- View/download PDF
29. Co-stimulation with LPS or Poly I:C markedly enhances the anti- platelet immune response and severity of fetal and neonatal alloimmune thrombo cytopenia.
- Author
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Conglei Li, Pingguo Chen, Vadasz, Brian, Li Ma, Hui Zhou, Sean Lang, Freedman, John, and Heyu Ni
- Published
- 2013
- Full Text
- View/download PDF
30. Novel Characterization Techniques for Additive Manufacturing Powder Feedstock
- Author
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Benjamin Young, Joseph Heelan, Sean Langan, Matthew Siopis, Caitlin Walde, and Aaron Birt
- Subjects
additive manufacturing ,metal powders ,cermet powders ,characterization ,cold spray ,Mining engineering. Metallurgy ,TN1-997 - Abstract
Additive manufacturing is a rapidly expanding field, encompassing many methods to manufacture parts and coatings with a wide variety of feedstock. Metal powders are one such feedstock, with a range of compositions and morphologies. Understanding subtle changes in the feedstock is critical to ensure successful consolidation and quality control of both the feedstock and manufactured part. Current standards lack the ability to finely distinguish almost acceptable powders from barely acceptable ones. Here, novel means of powder feedstock characterization for quality control are demonstrated for the solid-state AM process of cold spray, though similar methods may be extrapolated to other additive methods as well. These characterization methods aim to capture the physics of the process, which in cold spray consists of high strain rate deformation of solid-state feedstock. To capture this, in this effort powder compaction was evaluated via rapidly applied loads, flowability of otherwise non-flowable powders was evaluated with the addition of vibration, and powder electrical resistivity was evaluated through compaction between two electrodes. Several powders, including aluminum alloys, chromium, and cermet composites, were evaluated in this effort, with each case study demonstrating the need for non-traditional characterization metrics as a means of quality control and classification of these materials.
- Published
- 2021
- Full Text
- View/download PDF
31. Origin of superconductivity at nickel-bismuth interfaces
- Author
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Matthew Vaughan, Nathan Satchell, Mannan Ali, Christian J. Kinane, Gavin B. G. Stenning, Sean Langridge, and Gavin Burnell
- Subjects
Physics ,QC1-999 - Abstract
Unconventional superconductivity has been suggested to be present at the interface between bismuth and nickel in thin-film bilayers. In this work, we study the structural, magnetic, and superconducting properties of sputter deposited Bi/Ni bilayers. As-grown, our films do not display a superconducting transition; however, when stored at room temperature, after about 14 days our bilayers develop a superconducting transition up to 3.8 K. To systematically study the effect of low temperature annealing on our bilayers, we perform structural characterization with x-ray diffraction and polarized neutron reflectometry, along with magnetometry and low-temperature electrical transport measurements on samples annealed at 70^{∘}C. We show that the onset of superconductivity in our samples is coincident with the formation of ordered NiBi_{3} intermetallic alloy, a known s-wave superconductor. We calculate that the annealing process has an activation energy of (0.86±0.06)eV. As a consequence, gentle heating of the bilayers will cause formation of the superconducting NiBi_{3} at the Ni/Bi interface, which poses a challenge to studying any distinct properties of Bi/Ni bilayers without degrading that interface.
- Published
- 2020
- Full Text
- View/download PDF
32. Parliamentary Reform 1785-1928
- Author
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Sean Lang and Sean Lang
- Subjects
- JN543
- Abstract
Parliamentary Reform 1785–1928 surveys the dynamically changing role of the British Parliament from the pre-reformed Parliament through: the 1832 Great Reform Act Chartism the campaign for working class suffrage Catholic emancipation the long struggle for the granting of female suffrage. Beginning with a wide survey of the origins and nature of Parliament, the author offers a detailed context for the campaigns for its reformation of in the nineteenth century and the attitude of Victorians towards it. This comprehensive approach promotes understanding of the wider issues of parliamentary reform and provides an essential aid and context to students studying this topic.
- Published
- 1999
33. Observation of a temperature dependent asymmetry in the domain structure of a Pd-doped FeRh epilayer
- Author
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C J Kinane, M Loving, M A de Vries, R Fan, T R Charlton, J S Claydon, D A Arena, F Maccherozzi, S S Dhesi, D Heiman, C H Marrows, L H Lewis, and Sean Langridge
- Subjects
FeRh ,magnetic thin films ,magnetic phase transitions ,nucleation ,ferromagnetism ,antiferromagnetism ,Science ,Physics ,QC1-999 - Abstract
Using x-ray photoelectron emission microscopy we have observed the coexistence of ferromagnetic and antiferromagnetic phases in a (3 at%)Pd-doped FeRh epilayer. By quantitatively analyzing the resultant images we observe that as the epilayer transforms there is a change in magnetic domain symmetry from predominantly twofold at lower temperatures through to an equally weighted combination of both four and twofold symmetries at higher temperature. It is postulated that the lowered symmetry Ising-like nematic phase resides at the near-surface of the epilayer. This behavior is different to that of undoped FeRh suggesting that the variation in symmetry is driven by the competing structural and electronic interactions in the nanoscale FeRh film coupled with the effect of the chemical doping disorder.
- Published
- 2014
- Full Text
- View/download PDF
34. Holographic imaging of interlayer coupling in Co/Pt/NiFe
- Author
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Thomas A Duckworth, Feodor Y Ogrin, Guillaume Beutier, Sarnjeet S Dhesi, Stuart A Cavill, Sean Langridge, Amy Whiteside, Thomas Moore, Maxime Dupraz, Flora Yakhou, and Gerrit van der Laan
- Subjects
Science ,Physics ,QC1-999 - Abstract
We present a method to determine the magnetic configuration of an in-plane magnetized permalloy layer using Fourier transform holography with extended references in an off-normal geometry. We use a narrow slit as an extended holographic reference to record holograms with the sample surface orthogonal to the incident x-ray beam, as well as rotated by 30° and 45° with respect to the beam. To demonstrate the sensitivity of the technique to in-plane magnetization, we present images of flux closed ground states in thin (∼50 nm) permalloy elements, less than 1 μ m in lateral size. Images of the in-plane domain pattern which is magnetostatically imprinted into a permalloy film by the stray fields generated by an adjacent Co/Pt multilayer were obtained. It is found that, whilst the domain patterns within the two magnetic layers show a strong resemblance at remanence within a pristine sample, the similarities disappear after the sample is exposed to a saturating magnetic field.
- Published
- 2013
- Full Text
- View/download PDF
35. The maternal immune response to fetal platelet GPIbα causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies.
- Author
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Conglei Li, Piran, Siavash, Pingguo Chen, Sean Lang, Zarpellon, Alessandro, Jin, Joseph W., Guangheng Zhu, Reheman, Adili, van der Wal, Dianne E., Simpson, Elisa K., Ran Ni, Gross, Peter L., Ware, Jerry, Ruggeri, Zaverio M., Freedman, John, Heyu Ni, Li, Conglei, Chen, Pingguo, Lang, Sean, and Zhu, Guangheng
- Subjects
- *
LABORATORY mice , *IMMUNE response , *THROMBOCYTOPENIA , *RECURRENT miscarriage , *PATHOLOGY , *GENES - Abstract
Fetal and neonatal immune thrombocytopenia (FNIT) is a severe bleeding disorder caused by maternal antibody-mediated destruction of fetal/neonatal platelets. It is the most common cause of severe thrombocytopenia in neonates, but the frequency of FNIT-related miscarriage is unknown, and the mechanism(s) underlying fetal mortality have not been explored. Furthermore, although platelet αIIbβ3 integrin and GPIbα are the major antibody targets in immune thrombocytopenia, the reported incidence of anti-GPIbα-mediated FNIT is rare. Here, we developed mouse models of FNIT mediated by antibodies specific for GPIbα and β3 integrin and compared their pathogenesis. We found, unexpectedly, that miscarriage occurred in the majority of pregnancies in our model of anti-GPIbα-mediated FNIT, which was far more frequent than in anti-β3-mediated FNIT. Dams with anti-GPIbα antibodies exhibited extensive fibrin deposition and apoptosis/necrosis in their placentas, which severely impaired placental function. Furthermore, anti-GPIbα (but not anti-β3) antiserum activated platelets and enhanced fibrin formation in vitro and thrombus formation in vivo. Importantly, treatment with either intravenous IgG or a monoclonal antibody specific for the neonatal Fc receptor efficiently prevented anti-GPIbα-mediated FNIT. Thus, the maternal immune response to fetal GPIbα causes what we believe to be a previously unidentified, nonclassical FNIT (i.e., spontaneous miscarriage but not neonatal bleeding) in mice. These results suggest that a similar pathology may have masked the severity and frequency of human anti-GPIbα-mediated FNIT, but also point to possible therapeutic interventions. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
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