14 results on '"Scotti, Martina"'
Search Results
2. 2449: A loco-systemic score characterizing microvascular health predicts skin reactions after breast RT
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De Santis, Maria Carmen, Cicchetti, Alessandro, Catalano, Alessandra, Scotti, Martina, Materne, Sophie, Rocca, Eliana La, Colciago, Riccardo Ray, Pisani, Francesco, Badenchini, Fabio, Gioscio, Eliana, Possenti, Luca, and Rancati, Tiziana
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- 2024
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3. Epigenetic markers in inflammation-related genes associated with mood disorder: a cross-sectional and longitudinal study in high-risk offspring of bipolar parents
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Duffy, Anne, Goodday, Sarah M., Keown-Stoneman, Charles, Scotti, Martina, Maitra, Malosree, Nagy, Corina, Horrocks, Julie, and Turecki, Gustavo
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- 2019
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4. How Xylenol Orange and Ferrous Ammonium Sulphate Influence the Dosimetric Properties of PVA–GTA Fricke Gel Dosimeters: A Spectrophotometric Study.
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Scotti, Martina, Arosio, Paolo, Brambilla, Elisa, Gallo, Salvatore, Lenardi, Cristina, Locarno, Silvia, Orsini, Francesco, Pignoli, Emanuele, Pedicone, Luca, and Veronese, Ivan
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XYLENOL ,AMMONIUM sulfate ,SPECTROPHOTOMETRY ,RADIATION ,HYDROGELS - Abstract
The development of Fricke gel (FG) dosimeters based on poly(vinyl alcohol) (PVA) as the gelling agent and glutaraldehyde (GTA) as the cross-linker has enabled significant improvements in the dose response and the stability over time of spatial radiation dose distributions. However, a standard procedure for preparing FG in terms of reagent concentrations is still missing in the literature. This study aims to investigate, by means of spectrophotometric analyses, how the sensitivity to the radiation dose and the range of linearity of the dose–response curve of PVA-GTA-FG dosimeters loaded with xylenol orange sodium salt (XO) are influenced by ferrous ammonium sulphate (FAS) and XO concentrations. Moreover, the effect of different concentrations of such compounds on self-oxidation phenomena in the dosimeters was evaluated. PVA-GTA-FG dosimeters were prepared using XO concentrations in the range 0.04–0.80 mM and FAS in the range 0.05–5.00 mM. The optical absorbance properties and the dose response of FG were investigated in the interval 0.0–42.0 Gy. The results demonstrate that the amount of FAS and XO determines both the sensitivity to the absorbed dose and the interval of linearity of the dose–response curve. The study suggests that the best performances of FG dosimeters for spectrophotometric analyses can be obtained using 1.00–0.40 mM and 0.200–0.166 mM concentrations of FAS and XO, respectively. [ABSTRACT FROM AUTHOR]
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- 2022
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5. 2543: Characterization of the oxygen transport variation with dose on a cohort of breast cancer patients.
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Catalano, Alessandra, Cicchetti, Alessandro, Scotti, Martina, De Santis, Maria Carmen, Colciago, Riccardo Ray, Rocca, Eliana La, Badenchini, Fabio, Gioscio, Eliana, Possenti, Luca, Giandini, Tommaso, Materne, Sophie Veronique, and Rancati, Tiziana
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BREAST cancer , *CANCER patients , *OXYGEN - Published
- 2024
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6. Role of the homeodomain transcription factor Hoxa13 in embryonic development and formation of extra-embryonic structures
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Scotti, Martina and Kmita, Marie
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Hox genes ,placenta ,gènes Hox ,régulation transcriptionnelle ,allantois ,allantoïde ,transcriptional regulation ,muscles - Abstract
La famille des gènes Hox code pour des facteurs de transcription connus pour leur contribution essentielle à l’élaboration de l’architecture du corps et ce, au sein de tout le règne animal. Au cours de l’évolution chez les vertébrés, les gènes Hox ont été redéfinis pour générer toute une variété de nouveaux tissus/organes. Souvent, cette diversification s’est effectuée via des changements quant au contrôle transcriptionnel des gènes Hox. Chez les mammifères, la fonction de Hoxa13 n’est pas restreinte qu’à l’embryon même, mais s’avère également essentielle pour le développement de la vascularisation fœtale au sein du labyrinthe placentaire, suggérant ainsi que sa fonction au sein de cette structure aurait accompagné l’émergence des espèces placentaires. Au chapitre 2, nous mettons en lumière le recrutement de deux autres gènes Hoxa, soient Hoxa10 et Hoxa11, au compartiment extra-embryonnaire. Nous démontrons que l’expression de Hoxa10, Hoxa11 et Hoxa13 est requise au sein de l’allantoïde, précurseur du cordon ombilical et du système vasculaire fœtal au sein du labyrinthe placentaire. De façon intéressante, nous avons découvert que l’expression des gènes Hoxa10-13 dans l’allantoïde n’est pas restreinte qu’aux mammifères placentaires, mais est également présente chez un vertébré non-placentaire, indiquant que le recrutement des ces gènes dans l’allantoïde précède fort probablement l’émergence des espèces placentaires. Nous avons généré des réarrangements génétiques et utilisé des essais transgéniques pour étudier les mécanismes régulant l’expression des gènes Hoxa dans l’allantoïde. Nous avons identifié un fragment intergénique de 50 kb capable d’induire l’expression d’un gène rapporteur dans l’allantoïde. Cependant, nous avons trouvé que le mécanisme de régulation contrôlant l’expression du gène Hoxa au sein du compartiment extra-embryonnaire est fort complexe et repose sur plus qu’un seul élément cis-régulateur. Au chapitre 3, nous avons utilisé la cartographie génétique du destin cellulaire pour évaluer la contribution globale des cellules exprimant Hoxa13 aux différentes structures embryonnaires. Plus particulièrement, nous avons examiné plus en détail l’analyse de la cartographie du destin cellulaire de Hoxa13 dans les pattes antérieures en développement. Nous avons pu déterminer que, dans le squelette du membre, tous les éléments squelettiques de l’autopode (main), à l’exception de quelques cellules dans les éléments carpiens les plus proximaux, proviennent des cellules exprimant Hoxa13. En contraste, nous avons découvert que, au sein du compartiment musculaire, les cellules exprimant Hoxa13 et leurs descendantes (Hoxa13lin+) s’étendent à des domaines plus proximaux du membre, où ils contribuent à générer la plupart des masses musculaires de l’avant-bras et, en partie, du triceps. De façon intéressante, nous avons découvert que les cellules exprimant Hoxa13 et leurs descendantes ne sont pas distribuées uniformément parmi les différents muscles. Au sein d’une même masse musculaire, les fibres avec une contribution Hoxa13lin+ différente peuvent être identifiées et les fibres avec une contribution semblable sont souvent regroupées ensemble. Ce résultat évoque la possibilité que Hoxa13 soit impliqué dans la mise en place de caractéristiques spécifiques des groupes musculaires, ou la mise en place de connections nerf-muscle. Prises dans leur ensemble, les données ici présentées permettent de mieux comprendre le rôle de Hoxa13 au sein des compartiments embryonnaires et extra-embryonnaires. Par ailleurs, nos résultats seront d’une importance primordiale pour soutenir les futures études visant à expliquer les mécanismes transcriptionnels soutenant la régulation des gènes Hoxa dans les tissus extra-embryonnaires., The Hox family of transcription factors is well known for its key contribution in the establishment of the body architecture in all the animal kingdom. During vertebrate evolution, Hox genes have been co-opted to pattern a variety of novel tissues/organs. Often, this diversification has been achieved by changes in Hox transcriptional control. In mammals, Hoxa13 function is not restricted to the embryo proper, but is also essential for the proper development of the fetal vasculature within the placental labyrinth, suggesting that its function in this structure accompanied the emergence of placental species. In chapter 2, we report on the recruitment of two other Hoxa genes, namely Hoxa10 and Hoxa11, in the extra embryonic compartment. We show that Hoxa10, Hoxa11 and Hoxa13 expression is required in the allantois, the precursor of the umbilical cord and fetal vasculature within the placental labyrinth. Interestingly, we found that Hoxa10-13 gene expression in the allantois is not restricted to placental mammals, but is also present in a non-placental vertebrate, indicating that the recruitment of these genes in the allantois most likely predates the emergence of placental species. We generated genetic rearrangements and used transgenic assays to investigate the regulatory mechanisms underlying Hoxa gene expression in the allantois. We identified a 50 kb intergenic fragment able to drive reporter gene expression in the allantois. However, we found that the regulatory mechanism controlling Hoxa gene expression in the extra-embryonic compartment is very complex and relies on more than one cis-regulatory element. In chapter 3, we used genetic fate mapping to assess the overall contribution of Hoxa13 expressing cells to the different embryonic structures. In particular, we focused on Hoxa13 fate-mapping analysis in the developing forelimbs. We could determine that, in the limb skeleton, all autopod (hand) skeletal elements, with the exception of a few cells in the most proximal carpal elements, originate from Hoxa13 expressing cells. In contrast, we found that, in the muscle compartment, Hoxa13 expressing cells and their descendants extend to more proximal limb domains, where they contribute to most of the muscle masses of the forearm and, in part, to the triceps. Interestingly we found that Hoxa13 expressing cells and their descendants are not identically distributed among different muscles. Within the same muscular mass, fibres with different Hoxa13lin+ contribution can be identified, and fibers with similar contribution are often clustered together. This result raises the possibility that Hoxa13 might be involved in establishing specific features of muscle groups, or in establishing nerve-muscle connectivity. Altogether, the data presented herein provide a better understanding of the role of Hoxa13 in both the embryonic and extra-embryonic compartment. Moreover, our results will be of key importance for further investigations aimed at unravelling transcriptional mechanisms underlying Hoxa gene regulation in extra embryonic tissues.
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- 2012
7. A H oxa13:Cre mouse strain for conditional gene manipulation in developing limb, hindgut, and urogenital system.
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Scotti, Martina, Kherdjemil, Yacine, Roux, Marine, and Kmita, Marie
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- 2015
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8. Decoupling the function of Hox and Shh in developing limb reveals multiple inputs of Hox genes on limb growth.
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Sheth, Rushikesh, Grégoire, Damien, Dumouchel, Annie, Scotti, Martina, Trang Pham, Jessica My, Nemec, Stephen, Bastida, Maria Félix, Ros, Marian A., and Kmita, Marie
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HOMEOBOX genes ,GROWTH of the anatomical extremities ,HEDGEHOG signaling proteins ,FIBROBLAST growth factors ,CELL communication ,CELL proliferation ,MESENCHYMAL stem cells - Abstract
Limb development relies on an exquisite coordination between growth and patterning, but the underlying mechanisms remain elusive. Anterior-posterior and proximal-distal specification initiates in early limb bud concomitantly with the proliferative expansion of limb cells. Previous studies have shown that limb bud growth initially relies on fibroblast growth factors (FGFs) produced in the apical ectodermal ridge (AER-FGFs), the maintenance of which relies on a positive-feedback loop involving sonic hedgehog (Shh) and the BMP antagonist gremlin 1 (Grem1). The positive cross-regulation between Shh and the HoxA and HoxD clustered genes identified an indirect effect of Hox genes on the maintenance of AER-FGFs but the respective function of Shh and Hox genes in this process remains unknown. Here, by uncoupling Hox and Shh function, we show that HoxA and HoxD genes are required for proper AER-FGFs expression, independently of their function in controlling Shh expression. In addition, we provide evidence that the Hoxdependent control of AER-FGF expression is achieved through the regulation of key mesenchymal signals, namely Grem1 and Fgf10, ensuring proper epithelial-mesenchymal interactions. Notably, HoxA and HoxD genes contribute to both the initial activation of Grem1 and the subsequent anterior expansion of its expression domain. We propose that the intricate interactions between Hox genes and the FGF and Shh signaling pathways act as a molecular network that ensures proper limb bud growth and patterning, probably contributing to the coordination of these two processes. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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9. Sex‐specific contribution of DHEA‐cortisol ratio to prefrontal‐hippocampal structural development, cognitive abilities and personality traits.
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Farooqi, Nasr A. I., Scotti, Martina, Yu, Ally, Lew, Jimin, Monnier, Patricia, Botteron, Kelly N., Campbell, Benjamin C., Booij, Linda, Herba, Catherine M., Séguin, Jean R., Castellanos‐Ryan, Natalie, McCracken, James T, and Nguyen, Tuong‐Vi
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PERSONALITY , *PERSONALITY & intelligence , *HUMAN sexuality , *VERBAL memory , *CENTRAL nervous system , *YOUNG adults - Abstract
Although dehydroepiandrosterone (DHEA) may exert neuroprotective effects in the developing brain, prolonged or excessive elevations in cortisol may exert neurotoxic effects. The ratio between DHEA and cortisol (DC ratio) has been linked to internalising and externalising disorders, as well as cognitive performance, supporting the clinical relevance of this hormonal ratio during development. However, the brain mechanisms by which these effects may be mediated have not yet been identified. Furthermore, although there is evidence that the effects of cortisol in the central nervous system may be sexually dimorphic in humans, the opposite is true for DHEA, with human studies showing no sex‐specific associations in cortical thickness, cortico‐amygdalar or cortico‐hippocampal structural covariance. Therefore, it remains unclear whether sex moderates the developmental associations between DC ratio, brain structure, cognition and behaviour. In the present study, we examined the associations between DC ratio, structural covariance of the hippocampus with whole‐brain cortical thickness, and measures of personality, behaviour and cognition in a longitudinal sample of typically developing children, adolescents and young adults aged 6‐22 years (N = 225 participants [F = 128]; 355 scans [F = 208]), using mixed effects models that accounted for both within‐ and between‐subject variances. We found sex‐specific interactions between DC ratio and anterior cingulate cortex‐hippocampal structural covariance, with higher DC ratios being associated with a more negative covariance between these structures in girls, and a more positive covariance in boys. Furthermore, the negative prefrontal‐hippocampal structural covariance found in girls was associated with higher verbal memory and mathematical ability, whereas the positive covariance found in boys was associated with lower cooperativeness and reward dependence personality traits. These findings support the notion that the ratio between DHEA and cortisol levels may contribute, at least in part, to the development of sex differences in cognitive abilities, as well as risk for internalising/externalising disorders, via an alteration in prefrontal‐hippocampal structure during the transition from childhood to adulthood. [ABSTRACT FROM AUTHOR]
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- 2019
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10. Recruitment of 5' Hoxa genes in the allantois is essential for proper extra-embryonic function in placental mammals.
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Scotti, Martina and Kmita, Marie
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GENES , *MAMMALS - Abstract
An abstract of the article "Recruitment of 5' Hoxa genes in the allantois is essential for proper extra-embryonic function in placental mammals," by Marie Kmita and Martina Scotti is presented.
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- 2012
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11. 15-P016 Evolution of HoxA genes towards extra-embryonic functions
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Kmita, Marie and Scotti, Martina
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- 2009
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12. Hoxa13 regulation and function during embryonic development
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Scotti, Martina and Kmita, Marie
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- 2007
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13. GLI3 Constrains Digit Number by Controlling Both Progenitor Proliferation and BMP-Dependent Exit to Chondrogenesis
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Lopez-Rios, Javier, Speziale, Dario, Robay, Dimitri, Scotti, Martina, Osterwalder, Marco, Nusspaumer, Gretel, Galli, Antonella, Holländer, Georg A., Kmita, Marie, and Zeller, Rolf
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PROGENITOR cells , *CELL proliferation , *CELLULAR signal transduction , *CHONDROGENESIS , *HEDGEHOG signaling proteins , *MICE embryology , *GENE expression , *GENETIC regulation , *CELL differentiation - Abstract
Summary: Inactivation of Gli3, a key component of Hedgehog signaling in vertebrates, results in formation of additional digits (polydactyly) during limb bud development. The analysis of mouse embryos constitutively lacking Gli3 has revealed the essential GLI3 functions in specifying the anteroposterior (AP) limb axis and digit identities. We conditionally inactivated Gli3 during mouse hand plate development, which uncoupled the resulting preaxial polydactyly from known GLI3 functions in establishing AP and digit identities. Our analysis revealed that GLI3 directly restricts the expression of regulators of the G1–S cell-cycle transition such as Cdk6 and constrains S phase entry of digit progenitors in the anterior hand plate. Furthermore, GLI3 promotes the exit of proliferating progenitors toward BMP-dependent chondrogenic differentiation by spatiotemporally restricting and terminating the expression of the BMP antagonist Gremlin1. Thus, Gli3 is a negative regulator of the proliferative expansion of digit progenitors and acts as a gatekeeper for the exit to chondrogenic differentiation. [Copyright &y& Elsevier]
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- 2012
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14. A Hoxa13:Cre mouse strain for conditional gene manipulation in developing limb, hindgut, and urogenital system.
- Author
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Scotti M, Kherdjemil Y, Roux M, and Kmita M
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- Animals, Female, Forelimb cytology, Forelimb embryology, Forelimb metabolism, Gastrointestinal Tract cytology, Gastrointestinal Tract embryology, Homeodomain Proteins metabolism, Immunohistochemistry, In Situ Hybridization, Integrases genetics, Integrases metabolism, Limb Buds cytology, Limb Buds embryology, Male, Mice, Inbred C57BL, Mice, Transgenic, Muscles cytology, Muscles embryology, Muscles metabolism, Organogenesis genetics, Time Factors, Urogenital System cytology, Gastrointestinal Tract metabolism, Gene Expression Regulation, Developmental, Homeodomain Proteins genetics, Limb Buds metabolism, Urogenital System embryology, Urogenital System metabolism
- Abstract
The developing limb is a useful model for studying organogenesis and developmental processes. Although Cre alleles exist for conditional loss- or gain-of-function in limbs, Cre alleles targeting specific limb subdomains are desirable. Here we report on the generation of the Hoxa13:Cre line, in which the Cre gene is inserted in the endogenous Hoxa13 gene. We provide evidence that the Cre is active in embryonic tissues/regions where the endogenous Hoxa13 gene is expressed. Our results show that cells expressing Hoxa13 in developing limb buds contribute to the entire autopod (hand/feet) skeleton and validate Hoxa13 as a distal limb marker as far as the skeleton is concerned. In contrast, in the limb musculature, Cre-based fate mapping shows that almost all muscle masses of the zeugopod (forearm) and part of the triceps contain Hoxa13-expressing cells and/or their descendants. Besides the limb, the activity of the Cre is detectable in the urogenital system and the hindgut, primarily in the epithelium and smooth muscles. Together our data show that the Hoxa13:Cre allele is a useful tool for conditional gene manipulation in the urogenital system, posterior digestive tract, autopod and part of the limb musculature., (© 2015 Wiley Periodicals, Inc.)
- Published
- 2015
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