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137 results on '"Schultz M.J."'

2. High PEEP/low FiO2 ventilation is associated with lower mortality in COVID–19

Author

Ahuja, S., van Akkeren, J.P., Algera, A.G., Algoe, C.K., van Amstel, R.B., Artigas, A., Aydeniz, E., Bailey, M., van den Berg, A.E., van de Berg, P., Bergmans, D.C.J.J., van den Bersselaar, D.I., Bertens, F.A., Bevers, M., Bindels, A.J.G.H., Breel, J.S., de Bruin, S., Bruna, C.L., de Boer, M., Boer, D.P., den Boer, S., Boers, L.S., Bogerd, M.B., Bos, L.D., Bosman, B., Botta, M., de Bie, A.J.R., Baur, O.L., Buiteman-Kruizinga, L.A., Coene, W., Cremer, O.L., Daenen, K., Delmte, M., Determann, R.M., Dieperink, W., Di Leo, V., van Dijk, J., Dongelmans, D.A., Dormans, T., Endeman, H., Elting, L.M., Esmeijer, A.A., Filippini, D., Flim, J.M., Franke, H.S., Galek-aldridge, M.S., de Abreu, M.G. Gama, Girbes, A.R., Go, D.M., Goossen, R.L., de Graaff, M.J., Hagens, L.A., Hansen, H.J., Haringman, J.J., van der Heide, S.T., van der Heiden, P.L.J., Heijnen, N.F.L., Hiel, S.J.P., Hoeijmakers, L.L., Hol, L., Hollmann, M.W., Hoogendoorn, M.E., Horn, J., van der Horst, I., van der Horst, R., Huijben, J.A., Ie, E.L.K., van Ingen, L.E., Ivanov, D.P., Juffermans, N.P., Kranen, H.T., Kho, E., de Klerk, E.S., Koek, N., Gemert, A.W.M.M. Koopman-van, Koopmans, M., Kucukcelebi, S., Kuiper, M.A., Kuipers, L.J., Koornstra, E., Lokhorst, A., de Lange, D.W., Martin-Loeches, I., van Meenen, D.M.P., Mazzinari, G., Moeniralam, H., van Mourik, N., Myatra, S.N., Nijbroek, S.G., van Oosten, P., Offermans, M., Onrust, M., Oostdijk, E.A.N., Paulus, F., Pennartz, C.J., Peršec, J., Peters, V.J.T., Pillay, J.J., Pisani, L., Pisters, T., Prins, A., Purmer, I.M., Rettig, T.C.D., Rezaee, A.S., Roca, O., Roozeman, J., Rozendaal, J., Rosenberg, N.M., Schavemaker, R., Sciascera, A., Schuijt, M.T.U., Schultz, M.J., Neto, A.S. Serpa, Shrestha, G.S., van Silfhout, B., Sjoding, M., Sleeswijk, M.E., van Smaalen, K.M., Smit, M.R., Spronk, P.E., Šribar, A., Strang, A.C., Stilma, W., Swart, P., Tuinman, P.R., Tsonas, A.M., den Uil, C.A., Valk, C.M.A., Veen-Schra, F.L., Vlaar, A.P.J., Veldhuis, L.I., van der Ven, W.H., van der Ven, F.L.I.M., van Velzen, P., Verboom, M., Verhoef, E.J., Vermeulen, T.D., van Vliet, P., van Vliet, R., Voorham, J.S., van der Voort, P.H.J., van Welie, L., Weller, D., Wentink, A.R., Wesselink, H.J.F.T., van der Wier-Lubbers, H., van Wijk, B., van Willigen, H., van der Woude, M.C.E., Weiner, J.J., Winters, T., Wong, W.Y., Yaali, N., Zandvliet, J.M., van Zanten, A.R.H., van Zijl, T.Z.I., Zonneveld, S.A., Goossen, Robin L., van Vliet, Relin, Bos, Lieuwe D.J., Buiteman-Kruizinga, Laura A., Hollman, Markus W., Myatra, Sheila N., Neto, Ary Serpa, Spronk, Peter E., van der Woude, Meta C.E., van Meenen, David M.P., Paulus, Frederique, and Schultz, Marcus J.

Published
2024
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4. Prolonged indoleamine 2,3-dioxygenase-2 activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infection

Author

van Agtmael, M.A., Algera, A.G., Appelman, B., van Baarle, F.E.H.P., Beudel, M., Bogaard, H.J., Bomers, M., Bonta, P.I., Bos, L.D.J., Botta, M., de Brabander, J., de Bree, G.J., de Bruin, S., Bugiani, M., Bulle, E.B., Chouchane, O., Cloherty, A.P.M., Buis, D., de Rotte, M.C.F.J., Dijkstra, M., Dongelmans, D.A., Dujardin, R.W.G., Elbers, P.E., Fleuren, L.M., Geerlings, S.E., Geijtenbeek, T.B.H., Girbes, A.R.J., Goorhuis, A., Grobusch, M.P., Hagens, L.A., Hamann, J., Harris, V.C., Hemke, R., Hermans, S.M., Heunks, L.M.A., Hollmann, M.W., Horn, J., Hovius, J.W., de Jong, M.D., Koing, R., Lim, E.H.T., van Mourik, N., Nellen, J.F., Nossent, E.J., Paulus, F., Peters, E., Piña-Fuentes, D., van der Poll, T., Preckel, B., Prins, J.M., Raasveld, S.J., Reijnders, T.D.Y., Schinkel, M., Schrauwen, F.A.P., Schultz, M.J., Schuurman, A.R., Schuurmans, J., Sigaloff, K., Slim, M.A., Smeele, P., Smit, M.R., Stijnis, C., Stilma, W., Teunissen, C.E., Thoral, P., Tsonas, A.M., Tuinman, P.R., van der Valk, M., Veelo, D.P., Volleman, C., de Vries, H., van Vught, L.A., van Vugt, M., Wouters, D., Zwinderman, A.H., Brouwer, M.C., Wiersinga, W.J., Vlaar, A.P.J., van de Beek, D., Guo, Lihui, Appelman, Brent, Mooij-Kalverda, Kirsten, Houtkooper, Riekelt H., van Weeghel, Michel, Vaz, Frédéric M., Dijkhuis, Annemiek, Dekker, Tamara, Smids, Barbara S., Duitman, Jan Willem, Bugiani, Marianna, Brinkman, Paul, Sikkens, Jonne J., Lavell, H.A. Ayesha, Wüst, Rob C.I., van Vugt, Michèle, and Lutter, René

Published
2023
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6. Prognostication using SpO2/FiO2 in invasively ventilated ICU patients with ARDS due to COVID-19 – Insights from the PRoVENT-COVID study

Author

Algera, A.G., Boers, L.S., Bos, L.D.J., Botta, M., Dongelmans, D.A., Hollmann, M.W., Horn, J., Paulus, F., Pillay, J., Schultz, M.J., Neto, A. Serpa, Tsonas, A.M., Vlaar, A.P.J., Ahuja, S., van Akkeren, J.P., Algoe, C.K., van Amstel, R.B., Artigas, A., Baur, O.L., van de Berg, P., van den Berg, A.E., Bergmans, D.C.J.J., van den Bersselaar, D.I., Bertens, F.A., Bindels, A.J.G.H., de Boer, M.M., den Boer, S., Bogerd, M., Breel, J.S., de Bruin, H., de Bruin, S., Bruna, C.L., Buiteman-Kruizinga, L.A., Cremer, O.L., Determann, R.M., Dieperink, W., Franke, H.S., Galek-Aldridge, M.S., de Graaff, M.J., Hagens, L.A., Haringman, J.J., van der Heide, S.T., van der Heiden, P.L.J., Heijnen, N.F.L., Hiel, S.J.P., Hoeijmakers, L.L., Hol, L., Hoogendoorn, M.E., van der Horst, R., Ie, E.L.K., Ivanov, D., Juffermans, N.P., Kho, E., de Klerk, E.S., Gemert, A.W.M.M. Koopman-van, Koopmans, M., Kucukcelebi, S., Kuiper, M.A., de Lange, D.W., van Mourik, N., Nijbroek, S.G., Onrust, M., Oostdijk, E.A.N., Pennartz, C.J., Pisani, L., Purmer, I.M., Rettig, T.C.D., Roozeman, J.P., Schuijt, M.T.U., Sleeswijk, M.E., Smit, M.R., Spronk, P.E., Stilma, W., Strang, A.C., Tuinman, P.R., Valk, C.M.A., Veen-Schra, F.L., Veldhuis, L.I., van Velzen, P., van der Ven, W.H., van Vliet, P., van der Voort, P.H.J., van Welie, L., Wesselink, H.J.F.T., van der Wier-Lubbers, H.H., van Wijk, B., Winters, T., Wong, W.Y., van Zanten, A.R.H., Roozeman, Jan-Paul, Mazzinari, Guido, Serpa Neto, Ary, Hollmann, Markus W., Paulus, Frederique, Schultz, Marcus J., and Pisani, Luigi

Published
2022
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9. Longitudinal respiratory subphenotypes in patients with COVID-19-related acute respiratory distress syndrome: results from three observational cohorts

Author

van Akkeren, J.P., Algera, A.G., Algoe, C.K., van Amstel, R.B., Artigas, A., Baur, O.L., van de Berg, P., van den Berg, A.E., Bergmans, D.C.J.J., van den Bersselaar, D.I., Bertens, F.A., Bindels, A.J.G.H., de Boer, M.M., den Boer, S., Boers, L.S., Bogerd, M., Bos, L.D.J., Botta, M., Breel, J.S., de Bruin, H., de Bruin, S., Bruna, C.L., Buiteman-Kruizinga, L.A., Cremer, O., Determann, R.M., Dieperink, W., Dongelmans, D.A., Franke, H.S., Galek-Aldridge, M.S., de Graaff, M.J., Hagens, L.A., Haringman, J.J., van der Heide, S.T., van der Heiden, P.L.J., Heijnen, N.F.L., Hiel, S.J.P., Hoeijmakers, L.L., Hol, L., Hollmann, M.W., Hoogendoorn, M.E., Horn, J., van der Horst, R., Ie, E.L.K., Ivanov, D., Juffermans, N.P., Kho, E., de Klerk, E.S., Koopman-van Gemert, A.W.M.M., Koopmans, M., Kucukcelebi, S., Kuiper, M.A., de Lange, D.W., Martin-Loeches, I., Mazzinari, G., van Meenen, D.M.P., Morales-Quinteros, L., van Mourik, N., Nijbroek, S.G., Onrust, M., Oostdijk, E.A.N., Paulus, F., Pennartz, C.J., Pillay, J., Pisani, L., Purmer, I.M., Rettig, T.C.D., Roozeman, J.P., Schuijt, M.T.U., Schultz, M.J., Serpa Neto, A., Sleeswijk, M.E., Smit, M.R., Spronk, P.E., Stilma, W., Strang, A.C., Tsonas, A.M., Tuinman, P.R., Valk, C.M.A., Veen-Schra, F.L., Veldhuis, L.I., van Velzen, P., van der Ven, W.H., Vlaar, A.P.J., van Vliet, P., van der Voort, P.H.J., van Welie, L., Wesselink, H.J.F.T., van der Wier-Lubbers, H.H., van Wijk, B., Winters, T., Wong, W.Y., van Zanten, A.R.H., Bos, Lieuwe D J, Sjoding, Michael, Sinha, Pratik, Bhavani, Sivasubramanium V, Lyons, Patrick G, Bewley, Alice F, Botta, Michela, Tsonas, Anissa M, Serpa Neto, Ary, Schultz, Marcus J, Dickson, Robert P, and Paulus, Frederique

Published
2021
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10. Mortality associated with early changes in ARDS severity in COVID–19 patients – Insights from the PRoVENT–COVID study

Author

van Akkeren, J.P., Algera, A.G., Algoe, C.K., van Amstel, R.B., Baur, O.L., van de Berg, P., van den Berg, A.E., Bergmans, D.C.J.J., van den Bersselaar, D.I., Bertens, F.A., Bindels, A.J.G.H., de Boer, M.M., den Boer, S., Boers, L.S., Bogerd, M., Bos, L.D.J., Botta, M., Breel, J.S., de Bruin, H., de Bruin, S., Bruna, C.L., Buiteman-Kruizinga, L.A., Cremer, O., Determann, R.M., Dieperink, W., Dongelmans, D.A., Franke, H.S., Aldridge, M.S. Galek, de Graaff, M.J., Hagens, L.A., Haringman, J.J., Heijnen, N.F.L., Hiel, S., van der Heide, S.T., van der Heiden, P.L.J., Hoeijmakers, L.L., Hol, L., Hollmann, M.W., Hoogendoorn, M.E., Horn, J., van der Horst, R., Ie, E.L.K., Ivanov, D., Juffermans, N.P., Kho, E., de Klerk, E.S., Koopman, A.W.M., Koopmans, M., Kucukcelebi, S., Kuiper, M.A., de Lange, D.W., van Mourik, N., Martin-Loeches, I., Nijbroek, S.G., Onrust, M., Oostdijk, E.A.N., Paulus, F., Pennartz, C.J., Pillay, J., Pisani, L., Purmer, I.M., Rettig, T.C.D., Roozeman, J.P., Schuijt, M.T.U., Schultz, M.J., Neto, A. Serpa, Sleeswijk, M.E., Smit, M.R., Spronk, P.E., Stilma, W., Strang, A.C., Tsonas, A.M., Tuinman, P.R., Valk, C.M.A., Veen, F.L., Vlaar, A.P.J., Veldhuis, L.I., van Velzen, P., van der Ven, W.H., van Vliet, P., van der Voort, P., van der Wier, H.H., van Welie, L., Wesselink, H.J.F.T., van Wijk, B., Winters, T., Wong, W.Y., van Zanten, A.R.H., Schuijt, Michiel T.U., Martin-Loeches, Ignacio, Schultz, Marcus J., Paulus, Frederique, and Neto, Ary Serpa

Published
2021
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11. Head-to-head validation of six immunoassays for SARS-CoV-2 in hospitalized patients

Author

van Agtmael, M., Algera, A.G., van Baarle, F., Bax, D., Beudel, M., Bogaard, H.J., Bomers, M., Bos, L., Botta, M., de Brabander, J., Brouwer, M.C., de Bruin, S., Bugiani, M., Bulle, E., Chouchane, O., Cloherty, A., Elbers, P., Fleuren, L., Geerlings, S., Geerts, B., Geijtenbeek, T., Girbes, A., Goorhuis, A., Grobusch, M.P., Hafkamp, F., Hagens, L., Hamann, J., Harris, V., Hemke, R., Hermans, S.M., Heunks, L., Hollmann, M.W., Horn, J., Hovius, J.W., Koning, R., van Mourik, N., Nellen, J., Paulus, F., Peters, E., van der Poll, T., Preckel, B., Prins, J.M., Raasveld, J., Reijnders, T., Schinkel, M., Schultz, M.J., Schuurman, A., Sigaloff, K., Smit, M., Stijnis, C.S., Stilma, W., Thoral, P., Tsonas, A., van der Valk, M., Veelo, D., Vlaar, A.P.J., de Vries, H., Wiersinga, W.J., Wouters, D., Zwinderman, A.H., van de Beek, D., Zonneveld, Rens, Jurriaans, Suzanne, van Gool, Tom, Hofstra, Jorrit J., Hekker, Thecla A.M., Defoer, Pien, Broekhuizen-van Haaften, Patricia E., Wentink-Bonnema, Ellen M., Boonkamp, Lynn, Teunissen, Charlotte E., Heijboer, Annemieke C., Martens, Frans, de Bree, Godelieve, van Vugt, Michele, van Houdt, Robin, Schinkel, Janke, and de Jong, Menno D.

Published
2021
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12. Ventilation and outcomes following robotic-assisted abdominal surgery: an international, multicentre observational study

Author

Queiroz, Veronica N.F., da Costa, Luis Guilherme V., Takaoka, Flavio, Pelosi, Paolo, de Abreu, Marcelo Gama, Schultz, Marcus J., Serpa Neto, Ary, Barbosa, R.P., Canet, J., Cata, J.P., Cesar, D.S., Chaves, R.C.F., D’Orto, U.C., Da Costa, L.G.V., De Baerdemaeker, L., Galdi, J.R., Gama de Abreu, M., Gottumukkala, V., Hemmes, S.N.T., Hollmann, M.W., Kalmar, A.F., Mariano, R., Matot, I., Mazzinari, G., Mills, G.H., Pelosi, P., Posso, I.P., Queiroz, V.N.F., Schultz, M.J., Serpa Neto, A., Sprung, J., Takaoka, F., Teruya, A., Vidal Melo, M.F., Agarwala, Aalok V., Akeroyd, Louise, Andorlini, Francesco, Anicetti, Lisa, Antonelli, Massimo, Arantes, Bruno S., Ariño Irujo, Jose J., Artsi, Hanna, Babian, Renata, Barbosa, Rogerio P., Barker, Doug, Basagni, Diletta, Basso, Nicola, Beltran, Joan, Bocciero, Vittorio, Bonatti, Giulia, Boriati, Ernesto, Bravo, Mauro, Brazzi, Luca, Brearton, Chris, Brennan, Andrew, Bulinski, Adam M., Cafagna, Sara, Cardoni, Andrea, Castelló Mora, Paula, Cata, Juan P., Cesar, Daniel S., Chaves, Renato CF., Chen, Lee-Lynn, Chukkambotla, Srikanth, Ciccozzi, Alessandra, Cilia, Danae, Cope, Sean, D’Orto, Ulisses C., Da Costa, Luis Guilherme V., Dalton, Claire, Davi, Alessandra, De Bonis, Marina del Barrio, De Gaudio, Angelo Raffaele, De Luca, Lucilla, Delgado, Carlos C., Deljou, Atousa, Di Ruscio, Cecilia, Droger, Sijgje M., Duberley, Stephen, Eidelman, Leonid A., Evans, Alison, Fabiani, Constanza, Fasciano, Umberto, Firth-Gieben, Jennifer, Fitchett, Jillian, Fundarò, Angela, Galdi, Jose Roberto, Gallo, Verdiana, Gavagni, Mattia, Gottumukkala, Vijaya, Graham, Chris, Granell Gil, Manuel, Gratarola, Angelo, Grillandini, Chiara, Groeben, Harald-Thomas, Ismail, Nesrine, Jacob, Reni, Jones, Chris, Jones, Rebecca, Kalmar, Alain F., Kapoor, Ritoo, Kelliher, Leigh, Köhne, Wiebke, Koopman, Joseph SHA., Lanka, Prasad, Lee, Jae-Woo, Liban, Bernard, Livi, Francesca, Mariano, Renato, Martinez Plumed, Ruth, Matot, Idit, Mazzella, Marta, McClure, Stewart, McMonagle, Martina, Mills, Gary H., Mirabella, Lucia, Monsalve, Concepción, Moon, Angela, Morchio, Laura, Morris, Frances, Motroni, Lorenzo, Mura, Benedetta, Nerini, Alessandro, Noumedem Sonna, Elodia C., Oakes, Neil, Orlandi, Marina, Paladini, Antonella, Patil, Anita, Patil, Vishal, Patrone, Valentina, Pinder, Angela, Piroli, Alba, Posso, Irimar P., Queiroz, Veronica NF., Rabbu, Yosef S., Rabenalt, Robert, Romagnoli, Stefano, Ronen, Ariel, Rothman, Felipe, Rusagara, Patrick, Russo, Andrea, Sabov, Moldovan, Saitta, Thomas, Shah, Nirav, Smith, Neil, Sollazzi, Liliana, Sprung, Juraj, Stewart, Emma, Stones, Elizabeth, Storton, Kim, Tena, Beatriz, Terreni, Eleonora, Teruya, Alexandre, Travaglia, Chiara, Treschan, Tanja A., Vanoverschelde, Henk, Venkatesh, Harish, Vidal Melo, Marcos F., Villa, Gianluca, Vossen, Robbert, Webber, Stephen, Weingarten, Toby N., Willcocks, Matt, Winslow, Luke, and Woods, Lindsey

Published
2021
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13. Re–evaluation of the effects of high PEEP with recruitment manoeuvres versus low PEEP without recruitment manoeuvres during general anaesthesia for surgery – Protocol and statistical analysis plan for an individual patient data meta–analysis of PROVHILO, iPROVE and PROBESE

Author

Campos, N.S., Bluth, T., Hemmes, S.N.T., Librero, J., Pozo, N., Ferrando, C., Ball, L., Mazzinari, G., Pelosi, P., Gama de Abreu, M., Schultz, M.J., and Serpa Neto, A.

Published
2020
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14. Association between night-time surgery and occurrence of intraoperative adverse events and postoperative pulmonary complications

Author

Kroell, W., Metzler, H., Struber, G., Wegscheider, T., Gombotz, H., Hiesmayr, M., Schmid, W., Urbanek, B., Kahn, D., Momeni, M., Pospiech, A., Lois, F., Forget, P., Grosu, I., Poelaert, J., Mossevelde, V., van Malderen, M.C., Dylst, D., Melkebeek, J.V., Beran, M., Hert, S.D., Baerdemaeker, L.D., Heyse, B., Limmen, J.V., Wyffels, P., Jacobs, T., Roels, N., Bruyne, A.D., Velde, S.V.D., Marina, J.Z., Dejana, D.O., Pernar, S., Zunic, J., Miskovic, P., Zilic, A., Kvolik, S., Ivic, D., Darija, A.V., Skiljic, S., Vinkovic, H., Oputric, I., Juricic, K., Frkovic, V., Kopic, J., Mirkovic, I., Saric, J.P., Erceg, G., Dvorscak, M.B., Branka, M.S., Pavicic, A.M., Goranovic, T., Maldini, B., Radocaj, T., Gavranovic, Z., Inga, M.B., Sehovic, M., Stourac, P., Harazim, H., Smekalova, O., Kosinova, M., Kolacek, T., Hudacek, K., Drab, M., Brujevic, J., Vitkova, K., Jirmanova, K., Volfova, I., Dzurnakova, P., Liskova, K., Dudas, R., Filipsky, R., Kafrawy, S.E., Abdelwahab, H.H., Metwally, T., Ahmed, A.R., Ahmed Mostafa, E.S., Hasan, W.F., Ahmed, A.G., Yassin, H., Magdy, M., Abdelhady, M., Mahran, M., Herodes, E., Kivik, P., Oganjan, J., Aun, A., Sormus, A., Sarapuu, K., Mall, M., Karjagin, J., Futier, E., Petit, A., Gerard, A., Marret, E., Solier, M., Jaber, S., Prades, A., Krassler, J., Merzky, S., Abreu, M.G.D., Uhlig, C., Kiss, T., Bundy, A., Bluth, T., Gueldner, A., Spieth, P., Scharffenberg, M., Thiem, D.T., Koch, T., Treschan, T., Schaefer, M., Bastin, B., Geib, J., Weiss, M., Kienbaum, P., Pannen, B., Gottschalk, A., Konrad, M., Westerheide, D., Schwerdtfeger, B., Wrigge, H., Simon, P., Reske, A., Nestler, C., Valsamidis, D., Stroumpoulis, K., Antholopoulos, G., Andreou, A., Karapanos, D., Theodoraki, K., Gkiokas, G., Tasoulis, M.K., Sidiropoulou, T., Zafeiropoulou, F., Florou, P., Pandazi, A., Tsaousi, G., Nouris, C., Pourzitaki, C., Bystritski, D., Pizov, R., Eden, A., Pesce, C.V., Campanile, A., Marrella, A., Grasso, S., Michele, M.D., Bona, F., Giacoletto, G., Sardo, E., Sottosanti, L.G.V., Solca, M., Volta, C.A., Spadaro, S., Verri, M., Ragazzi, R., Zoppellari, R., Cinnella, G., Raimondo, P., Bella, D.L., Mirabella, L., D'antini, D., Pelosi, P., Molin, A., Brunetti, I., Gratarola, A., Pellerano, G., Sileo, R., Pezzatto, S., Montagnani, L., Pasin, L., Landoni, G., Zangrillo, A., Beretta, L., Parma, A.L.D., Tarzia, V., Dossi, R., Sassone, M.E., Sances, D., Tredici, S., Spano, G., Castellani, G., Delunas, L., Peradze, S., Venturino, M., Arpino, I., Sher, S., Tommasino, C., Rapido, F., Morelli, P., Vargas, M., Servillo, G., Cortegiani, A., Raineri, S.M., Montalto, F., Russotto, V., Giarratano, A., Baciarello, M., Generali, M., Cerati, G., Leykin, Y., Bressan, F., Bartolini, V., Zamidei, L., Brazzi, L., Liperi, C., Sales, G., Pistidda, L., Severgnini, P., Brugnoni, E., Musella, G., Bacuzzi, A., Muhardri, D., Agreta, G.G., Sada, F., Bytyqi, A., Karbonskiene, A., Aukstakalniene, R., Teberaite, Z., Salciute, E., Tikuisis, R., Miliauskas, P., Jurate, S., Kontrimaviciute, E., Tomkute, G., Xuereb, J., Bezzina, M., Borg, F. Joseph, Hemmes, S., Schultz, M., Hollmann, M., Wiersma, I., Binnekade, J., Bos, L., Boer, C., Duvekot, A., Veld, B.I ‘t, Werger, A., Dennesen, P., Severijns, C., Jong, J.D., Hering, J., Beek, R.V., Ivars, S., Jammer, I.B., Breidablik, A., Hodt, K.S., Fjellanger, F., Avalos, M.V., Jannicke, M.O., Andersson, E., Amir, S.K., Molina, R., Wutai, S., Morais, E., Tareco, G., Ferreira, D., Amaral, J., Castro, M.D.L.G., Cadilha, S., Appleton, S., Parente, S., Correia, M., Martins, D., Monteirosa, A., Ricardo, A., Rodrigues, S., Horhota, L., Grintescu, I.M., Mirea, L., Grintescu, I.C., Corneci, D., Negoita, S., Dutu, M., Popescu Garotescu, I., Filipescu, D., Prodan, A.B., Droc, G., Fota, R., Popescu, M., Tomescu, D., Petcu, A.M., Tudoroiu, M.I., Moise, A., Guran, C.T., Gherghina, I., Costea, D., Cindea, I., Copotoiu, S.M., Copotoiu, R., Barsan, V., Tolcser, Z., Riciu, M., Moldovan, S.G., Veres, M., Gritsan, A., Kapkan, T., Gritsan, G., Korolkov, O., Kulikov, A., Lubnin, A., Ovezov, A., Prokoshev, P., Lugovoy, A., Anipchenko, N., Babayants, A., Komissarova, I., Zalina, K., Likhvantsev, V., Fedorov, S., Lazukic, A., Pejakovic, J., Mihajlovic, D., Kusnierikova, Z., Zelinkova, M., Bruncakova, K., Polakovicova, L., Sobona, V., Barbka, N.S., Ana, P.G., Jovanov, M., Strazisar, B., Jasmina, M.B., Vesna, N.J., Voje, M., Grynyuk, A., Kostadinov, I., Alenka, S.V., Moral, V., Unzueta, M.C., Puigbo, C., Fava, J., Canet, J., Moret, E., Nunez, M.R., Sendra, M., Brunelli, A., Rodenas, F., Monedero, P., Hidalgo, F., Yepes, M.J., Martinez-Simon, A., Abajo, A., Lisi, A., Perez, G., Martinez, R., Granell, M., Vivo, J.T., Ruiz, C.S., Andrés Ibañez, J.A.D., Pastor, E., Soro, M., Ferrando, C., Defez, M., Cesar Aldecoa, A.S., Perez, R., Rico, J., Jawad, M., Saeed, Y., Gillberg, L., Bengisun, Z.K., Kazbek, B.K., Coskunfirat, N., Boztug, N., Sanli, S., Yilmaz, M., Hadimioglu, N., Senturk, N.M., Camci, E., Kucukgoncu, S., Sungur, Z., Sivrikoz, N., Ozgen, S.U., Toraman, F., Selvi, O., Senturk, O., Yildiz, M., Kuvaki, B., Gunenc, F., Kucukguclu, S., Ozbilgin, S., Maral, J., Canli, S., Arun, O., Saltali, A., Aydogan, E., Akgun, F.N., Sanlikarip, C., Karaman, F.M., Mazur, A., Vorotyntsev, S., Rousseau, G., Barrett, C., Stancombe, L., Shelley, B., Scholes, H., Limb, J., Rafi, A., Wayman, L., Deane, J., Rogerson, D., Williams, J., Yates, S., Rogers, E., Pulletz, M., Moreton, S., Jones, S., Venkatesh, S., Burton, M., Brown, L., Goodall, C., Rucklidge, M., Fuller, D., Nadolski, M., Kusre, S., Lundberg, M., Everett, L., Nutt, H., Zuleika, M., Carvalho, P., Clements, D., Ben, C.B., Watt, P., Raymode, P., Pearse, R., Mohr, O., Raj, A., Creary, T., Chishti, A., Bell, A., Higham, C., Cain, A., Gibb, S., Mowat, S., Franklin, D., West, C., Minto, G., Boyd, N., Mills, G., Calton, E., Walker, R., Mackenzie, F., Ellison, B., Roberts, H., Chikungwa, M., Jackson, C., Donovan, A., Foot, J., Homan, E., Montgomery, J., Portch, D., Mercer, P., Palmer, J., Paddle, J., Fouracres, A., Datson, A., Andrew, A., Welch, L., Rose, A., Varma, S., Simeson, K., Rambhatla, M., Susarla, J., Marri, S., Kodaganallur, K., Das, A., Algarsamy, S., Colley, J., Davies, S., Szewczyk, M., Smith, T., Ana, F.B., Luzier, E., Almagro, A., Melo, M.V., Fernando, L., Sulemanji, D., Sprung, J., Weingarten, T., Kor, D., Scavonetto, F., Tze, Y., Gregoretti, C., Neto, A.S., Hemmes, S.N.T., Ball, L., Hollmann, M.W., Mills, G.H., Melo, M.F.V., Putensen, C., Gama de Abreu, M., and Schultz, M.J.

Published
2019
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16. A systematic review and consensus definitions for standardised end-points in perioperative medicine: pulmonary complications

Author

Myles, P., Gan, T.J., Kurz, A., Peyton, P., Sessler, D., Tramèr, M., Cyna, A., De Oliveira, G.S., Jr., Wu, C., Jensen, M., Kehlet, H., Botti, M., Boney, O., Haller, G., Grocott, M., Cook, T., Fleisher, L., Neuman, M., Story, D., Gruen, R., Bampoe, S., Evered, Lis, Scott, D., Silbert, B., van Dijk, D., Kalkman, C., Chan, M., Grocott, H., Eckenhoff, R., Rasmussen, L., Eriksson, L., Beattie, S., Wijeysundera, D., Landoni, G., Leslie, K., Biccard, B., Howell, S., Nagele, P., Richards, T., Lamy, A., Gabreu, M., Klein, A., Corcoran, T., Jamie Cooper, D., Dieleman, S., Diouf, E., McIlroy, D., Bellomo, R., Shaw, A., Prowle, J., Karkouti, K., Billings, J., Mazer, D., Jayarajah, M., Murphy, M., Bartoszko, J., Sneyd, R., Morris, S., George, R., Moonesinghe, R., Shulman, M., Lane-Fall, M., Nilsson, U., Stevenson, N., van Klei, W., Cabrini, L., Miller, T., Pace, N., Jackson, S., Buggy, D., Short, T., Riedel, B., Gottumukkala, V., Alkhaffaf, B., Johnson, M., Abbott, T.E.F., Fowler, A.J., Pelosi, P., Gama de Abreu, M., Møller, A.M., Canet, J., Creagh-Brown, B., Mythen, M., Gin, T., Lalu, M.M., Futier, E., Grocott, M.P., Schultz, M.J., and Pearse, R.M.

Published
2018
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25. Infection control in the intensive care unit: expert consensus statements for SARS-CoV-2 using a Delphi method

Author

Nasa, P. Azoulay, E. Chakrabarti, A. Divatia, J.V. Jain, R. Rodrigues, C. Rosenthal, V.D. Alhazzani, W. Arabi, Y.M. Bakker, J. Bassetti, M. De Waele, J. Dimopoulos, G. Du, B. Einav, S. Evans, L. Finfer, S. Guérin, C. Hammond, N.E. Jaber, S. Kleinpell, R.M. Koh, Y. Kollef, M. Levy, M.M. Machado, F.R. Mancebo, J. Martin-Loeches, I. Mer, M. Niederman, M.S. Pelosi, P. Perner, A. Peter, J.V. Phua, J. Piquilloud, L. Pletz, M.W. Rhodes, A. Schultz, M.J. Singer, M. Timsit, J.-F. Venkatesh, B. Vincent, J.-L. Welte, T. Myatra, S.N.

Abstract

During the current COVID-19 pandemic, health-care workers and uninfected patients in intensive care units (ICUs) are at risk of being infected with SARS-CoV-2 as a result of transmission from infected patients and health-care workers. In the absence of high-quality evidence on the transmission of SARS-CoV-2, clinical practice of infection control and prevention in ICUs varies widely. Using a Delphi process, international experts in intensive care, infectious diseases, and infection control developed consensus statements on infection control for SARS-CoV-2 in an ICU. Consensus was achieved for 31 (94%) of 33 statements, from which 25 clinical practice statements were issued. These statements include guidance on ICU design and engineering, health-care worker safety, visiting policy, personal protective equipment, patients and procedures, disinfection, and sterilisation. Consensus was not reached on optimal return to work criteria for health-care workers who were infected with SARS-CoV-2 or the acceptable disinfection strategy for heat-sensitive instruments used for airway management of patients with SARS-CoV-2 infection. Well designed studies are needed to assess the effects of these practice statements and address the remaining uncertainties. © 2022 Elsevier Ltd

Published
2022

28. Imatinib in patients with severe COVID-19: a randomised, doubleblind, placebo-controlled, clinical trial (vol 9, pg 957, 2021)

Author

Aman, J., Duijvelaar, E., Botros, L., Kianzad, A., Schippers, J.R., Smeele, P.J., Azhang, S., Bartelink, I.H., Bayoumy, A.A., Bet, P.M., Boersma, W., Bonta, P.I., Boomars, K.A.T., Bos, L.D.J., Bragt, J.J.M.H. van, Braunstahl, G.J., Celant, L.R., Eger, K.A.B., Geelhoed, J.J.M., Glabbeek, Y.L.E. van, Grotjohan, H.P., Hagens, L.A., Happe, C.M., Hazes, B.D., Heunks, L.M.A., Heuvel, M. van den, Hoefsloot, W., Hoek, R.J.A., Hoekstra, R., Hofstee, H.M.A., Juffermans, N.P., Kemper, E.M., Kos, R., Kunst, P.W.A., Lammers, A., Lee, I. van der, Lee, E.L. van der, Maitland-van der Zee, A.H., Asam, P.F.M.M., Mieras, A., Muller, M., Neefjes, E.C.W., Nossent, E.J., Oswald, L.M.A., Overbeek, M.J., Pamplona, C.C., Paternotte, N., Pronk, N., Raaf, M.A. de, Raaij, B.F.M. van, Reijrink, M., Schultz, M.J., Neto, A.S., Slob, E.M.A., Smeenk, F.W.J.M., Smit, M.R., Smits, A.J., Stalenhoef, J.E., Tuinman, P.R., Vanhov, A.L.E.M., Wessels, J.N., Wezenbeek, J.C.C. van, Noordegraaf, A.V., Ma, F.S. de, and Bogaard, H.J.

Published
2021

30. Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

Author

Bastard, P. Gervais, A. Voyer, T.L. Rosain, J. Philippot, Q. Manry, J. Michailidis, E. Hoffmann, H.-H. Eto, S. Garcia-Prat, M. Bizien, L. Parra-Martínez, A. Yang, R. Haljasmägi, L. Migaud, M. Särekannu, K. Maslovskaja, J. De Prost, N. Tandjaoui-Lambiotte, Y. Luyt, C.-E. Amador-Borrero, B. Gaudet, A. Poissy, J. Morel, P. Richard, P. Cognasse, F. Troya, J. Trouillet-Assant, S. Belot, A. Saker, K. Garçon, P. Rivière, J.G. Lagier, J.-C. Gentile, S. Rosen, L.B. Shaw, E. Morio, T. Tanaka, J. Dalmau, D. Tharaux, P.-L. Sene, D. Stepanian, A. Megarbane, B. Triantafyllia, V. Fekkar, A. Heath, J.R. Franco, J.L. Anaya, J.-M. Solé-Violán, J. Imberti, L. Biondi, A. Bonfanti, P. Castagnoli, R. Delmonte, O.M. Zhang, Y. Snow, A.L. Holland, S.M. Biggs, C.M. Moncada-Vélez, M. Arias, A.A. Lorenzo, L. Boucherit, S. Coulibaly, B. Anglicheau, D. Planas, A.M. Haerynck, F. Duvlis, S. Nussbaum, R.L. Ozcelik, T. Keles, S. Bousfiha, A.A. El Bakkouri, J. Ramirez-Santana, C. Paul, S. Pan-Hammarström, Q. Hammarström, L. Dupont, A. Kurolap, A. Metz, C.N. Aiuti, A. Casari, G. Lampasona, V. Ciceri, F. Barreiros, L.A. Dominguez-Garrido, E. Vidigal, M. Zatz, M. Van De Beek, D. Sahanic, S. Tancevski, I. Stepanovskyy, Y. Boyarchuk, O. Nukui, Y. Tsumura, M. Vidaur, L. Tangye, S.G. Burrel, S. Duffy, D. Quintana-Murci, L. Klocperk, A. Kann, N.Y. Shcherbina, A. Lau, Y.-L. Leung, D. Coulongeat, M. Marlet, J. Koning, R. Reyes, L.F. Chauvineau-Grenier, A. Venet, F. Monneret, G. Nussenzweig, M.C. Arrestier, R. Boudhabhay, I. Baris-Feldman, H. Hagin, D. Wauters, J. Meyts, I. Dyer, A.H. Kennelly, S.P. Bourke, N.M. Halwani, R. Sharif-Askari, N.S. Dorgham, K. Sallette, J. Sedkaoui, S.M. AlKhater, S. Rigo-Bonnin, R. Morandeira, F. Roussel, L. Vinh, D.C. Ostrowski, S.R. Condino-Neto, A. Prando, C. Bondarenko, A. Spaan, A.N. Gilardin, L. Fellay, J. Lyonnet, S. Bilguvar, K. Lifton, R.P. Mane, S. Anderson, M.S. Boisson, B. Béziat, V. Zhang, S.-Y. Andreakos, E. Hermine, O. Pujol, A. Peterson, P. Mogensen, T.H. Rowen, L. Mond, J. Debette, S. De Lamballerie, X. Duval, X. Mentré, F. Zins, M. Soler-Palacin, P. Colobran, R. Gorochov, G. Solanich, X. Susen, S. Martinez-Picado, J. Raoult, D. Vasse, M. Gregersen, P.K. Piemonti, L. Rodríguez-Gallego, C. Notarangelo, L.D. Su, H.C. Kisand, K. Okada, S. Puel, A. Jouanguy, E. Rice, C.M. Tiberghien, P. Zhang, Q. Cobat, A. Abel, L. Casanova, J.-L. Alavoine, L. Behillil, S. Burdet, C. Charpentier, C. Dechanet, A. Descamps, D. Ecobichon, J.-L. Enouf, V. Frezouls, W. Houhou, N. Kafif, O. Lehacaut, J. Letrou, S. Lina, B. Lucet, J.-C. Manchon, P. Nouroudine, M. Piquard, V. Quintin, C. Thy, M. Tubiana, S. Van Der Werf, S. Vignali, V. Visseaux, B. Yazdanpanah, Y. Chahine, A. Waucquier, N. Migaud, M.-C. Deplanque, D. Djossou, F. Mergeay-Fabre, M. Lucarelli, A. Demar, M. Bruneau, L. Gerardin, P. Maillot, A. Payet, C. Laviolle, B. Laine, F. Paris, C. Desille-Dugast, M. Fouchard, J. Malvy, D. Nguyen, D. Pistone, T. Perreau, P. Gissot, V. Le Goas, C. Montagne, S. Richard, L. Chirouze, C. Bouiller, K. Desmarets, M. Meunier, A. Lefevre, B. Jeulin, H. Legrand, K. Lomazzi, S. Tardy, B. Gagneux-Brunon, A. Bertholon, F. Botelho-Nevers, E. Christelle, K. Nicolas, L. Roufai, L. Amat, K. Couffin-Cadiergues, S. Esperou, H. Hendou, S. Townsend, L. Cheallaigh, C.N. Bergin, C. Martin-Loeches, I. Dunne, J. Conlon, N. O'Farrelly, C. Abad, J. Accordino, G. Achille, C. Aguilera-Albesa, S. Aguilo-Cucurull, A. Ozkan, E.A. Darazam, I.A. Albisures, J.A.R. Aldave, J.C. Ramos, M.A. Khan, T.A. Aliberti, A. Nadji, S.A. Alkan, G. AlKhater, S.A. Allardet-Servent, J. Allende, L.M. Alonso-Arias, R. Alshahrani, M.S. Alsina, L. Alyanakian, M.-A. Borrero, B.A. Amoura, Z. Antoli, A. Aubart, M. Auguet, T. Avramenko, I. Aytekin, G. Azot, A. Bahram, S. Bajolle, F. Baldanti, F. Baldolli, A. Ballester, M. Feldman, H.B. Barrou, B. Barzaghi, F. Basso, S. Bayhan, G.I. Bezrodnik, L. Bilbao, A. Blanchard-Rohner, G. Blanco, I. Blandinieres, A. Blazquez-Gamero, D. Bleibtreu, A. Bloomfield, M. Bolivar-Prados, M. Borghesi, A. Borie, R. Botdhlo-Nevers, E. Bousquet, A. Boutolleau, D. Bouvattier, C. Bravais, J. Briones, M.L. Brunner, M.-E. Bruno, R. Bueno, M.R.P. Bukhari, H. Bustamante, J. Agra, J.J.C. Capra, R. Carapito, R. Carrabba, M. Casasnovas, C. Caseris, M. Cassaniti, I. Castelle, M. Castelli, F. De Vera, M.C. Castro, M.V. Catherinot, E. Celik, J.B. Ceschi, A. Chalumeau, M. Charbit, B. Cheng, M.P. Clave, P. Clotet, B. Codina, A. Cohen, Y. Comarmond, C. Combes, A. Comoli, P. Corsico, A.G. Coşkuner, T. Cvetkovski, A. Cyrus, C. Danion, F. Darley, D.R. Das, V. Dauby, N. Dauger, S. De Munter, P. De Pontual, L. Dehban, A. Delplancq, G. Demoule, A. Desguerre, I. Di Sabatino, A. Diehl, J.-L. Dobbelaere, S. Dubost, C. Ekwall, O. Bozdemir, Ş.E. Elnagdy, M.H. Emiroglu, M. Endo, A. Erdeniz, E.H. Aytekin, S.E. Lasa, M.P.E. Euvrard, R. Fabio, G. Faivre, L. Falck, A. Fartoukh, M. Faure, M. Arquero, M.F. Ferrer, R. Ferreres, J. Flores, C. Francois, B. Fumado, V. Fung, K.S.C. Fusco, F. Gagro, A. Solis, B.G. Gaussem, P. Gayretli, Z. Gil-Herrera, J. Gatineau, A.G. Girona-Alarcon, M. Godinez, K.A.C. Goffard, J.-C. Gonzales, N. Gonzalez-Granado, L.I. Gonzalez-Montelongo, R. Guerder, A. Gulhan, B. Gumucio, V.D. Hanitsch, L.G. Gunst, J. Gut, M. Hadjadj, J. Hancerli, S. Hariyan, T. Hatipoglu, N. Heppekcan, D. Hernandez-Brito, E. Ho, P.-K. Holanda-Pena, M.S. Horcajada, J.P. Hraiech, S. Humbert, L. Hung, I.F.N. Iglesias, A.D. Inigo-Campos, A. Jamme, M. Arranz, M.J. Jimeno, M.-T. Jordan, I. Kanik-Yuksek, S. Kara, Y.B. Karahan, A. Karbuz, A. Yasar, K.K. Kasapcopur, O. Kashimada, K. Demirkol, Y.K. Kido, Y. Kizil, C. Kilic, A.O. Koutsoukou, A. Krol, Z.J. Ksouri, H. Kuentz, P. Kwan, A.M.C. Kwan, Y.W.M. Kwok, J.S.Y. Lam, D.S.Y. Lampropoulou, V. Lanternier, F. Le Bourgeois, F. Leo, Y.-S. Lopez, R.L. Levin, M. Levy, M. Levy, R. Li, Z. Lilleri, D. Lima, E.J.A.B. Linglart, A. Lopez-Collazo, E. Lorenzo-Salazar, J.M. Louapre, C. Lubetzki, C. Lung, K.-C. Lye, D.C. Magnone, C. Mansouri, D. Marchioni, E. Marioli, C. Marjani, M. Marques, L. Pereira, J.M. Martin-Nalda, A. Pueyo, D.M. Marzana, I. Mata-Martinez, C. Mathian, A. Matos, L.R.B. Matthews, G.V. Mayaux, J. McLaughlin-Garcia, R. Meersseman, P. Mege, J.-L. Mekontso-Dessap, A. Melki, I. Meloni, F. Meritet, J.-F. Merlani, P. Akcan, O.M. Mezidi, M. Migeotte, I. Millereux, M. Million, M. Mirault, T. Mircher, C. Mirsaeidi, M. Mizoguchi, Y. Modi, B.P. Mojoli, F. Moncomble, E. Melian, A.M. Martinez, A.M. Morange, P.-E. Mordacq, C. Morelle, G. Mouly, S.J. Munoz-Barrera, A. Nafati, C. Nagashima, S. Nakagama, Y. Neven, B. Neves, J.F. Ng, L.F.P. Ng, Y.-Y. Nielly, H. Medina, Y.N. Cuadros, E.N. Ocejo-Vinyals, J.G. Okamoto, K. Oualha, M. Ouedrani, A. Ozkaya-Parlakay, A. Pagani, M. Papadaki, M. Parizot, C. Parola, P. Pascreau, T. Paz-Artal, E. Pedraza, S. Pellecer, N.C.G. Pellegrini, S. De Diego, R.P. Perez-Fernandez, X.L. Philippe, A. Picod, A. De Chambrun, M.P. Piralla, A. Planas-Serra, L. Ploin, D. Poncelet, G. Poulakou, G. Pouletty, M.S. Pourshahnazari, P. Qiu-Chen, J.L. Quentric, P. Rambaud, T. Raoult, V. Rebillat, A.-S. Redin, C. Resmini, L. Ricart, P. Richard, J.-C. Rivet, N. Rocamora-Blanch, G. Rodero, M.P. Rodrigo, C. Rodriguez, L.A. Rodriguez-Palmero, A. Romero, C.S. Rothenbuhler, A. Roux, D. Rovina, N. Rozenberg, F. Ruch, Y. Ruiz, M. Del Prado, M.Y.R. Ruiz-Rodriguez, J.C. Sabater-Riera, J. Saks, K. Salagianni, M. Sanchez, O. Sanchez-Montalva, A. Sanchez-Ramon, S. Schidlowski, L. Schluter, A. Schmidt, J. Schmidt, M. Schuetz, C. Schweitzer, C.E. Scolari, F. Sediva, A. Seijo, L. Seminario, A.G. Seng, P. Senoglu, S. Seppanen, M. Llovich, A.S. Shahrooei, M. Siguret, V. Siouti, E. Smadja, D.M. Smith, N. Sobh, A. Soler, C. Sozeri, B. Stella, G.M. Stepanovskiy, Y. Stoclin, A. Taccone, F. Taupin, J.-L. Tavernier, S.J. Terrier, B. Thiery, G. Thorball, C. Thorn, K. Thumerelle, C. Tipu, I. Tolstrup, M. Tomasoni, G. Toubiana, J. Alvarez, J.T. Tsang, O.T.Y. Tserel, L. Tso, E.Y.K. Tucci, A. Oz, Ş.K.T. Ursini, M.V. Utsumi, T. Uzunhan, Y. Vabres, P. Valencia-Ramos, J. Van Den Rym, A.M. Vandernoot, I. Velez-Santamaria, V. Veliz, S.P.Z. Vidigal, M.C. Viel, S. Vilain, C. Vilaire-Meunier, M.E. Villar-Garcia, J. Vincent, A. Vogt, G. Voiriot, G. Volokha, A. Vuotto, F. Wauters, E. Wu, A.K.L. Wu, T.-C. Yahşi, A. Yesilbas, O. Yildiz, M. Young, B.E. Yukselmiş, U. Zecca, M. Zuccaro, V. Van Praet, J. Lambrecht, B.N. Van Braeckel, E. Bosteels, C. Hoste, L. Hoste, E. Bauters, F. De Clercq, J. Heijmans, C. Slabbynck, H. Naesens, L. Florkin, B. Boulanger, C. Vanderlinden, D. Allavena, C. Andrejak, C. Angoulvant, F. Azoulay, C. Bachelet, D. Bartoli, M. Basmaci, R. Behillill, S. Beluze, M. Benech, N. Benkerrou, D. Bhavsar, K. Bitker, L. Bouadma, L. Bouscambert-Duchamp, M. Paz, P.C. Cervantes-Gonzalez, M. Chair, A. Coelho, A. Cordel, H. Couffignal, C. D'Ortenzio, E. De Montmollin, E. Debard, A. Debray, M.-P. Desvallee, M. Diallo, A. Diouf, A. Dorival, C. Dubos, F. Eloy, P. Epaulard, O. Esposito-Farase, M. Etienne, M. Garot, D. Gault, N. Gaymard, A. Ghosn, J. Gigante, T. Gilg, M. Goehringer, F. Guedj, J. Hoctin, A. Hoffmann, I. Houas, I. Hulot, J.-S. Jaafoura, S. Kaguelidou, F. Kali, S. Kerroumi, Y. Khalil, A. Khan, C. Kimmoun, A. Laouenan, C. Laribi, S. Le, M. Le Bris, C. Le Gac, S. Le Hingrat, Q. Le Mestre, S. Le Nagard, H. Lemaignen, A. Lemee, V. Lescure, F.-X. Levy, Y. Lingas, G. Lucet, J.C. MacHado, M. Mambert, M. Manuel, A. Meziane, A. Mouquet, H. Mullaert, J. Neant, N. Noret, M. Papadopoulos, A. Paul, C. Peiffer-Smadja, N. Peigne, V. Petrov-Sanchez, V. Peytavin, G. Pham, H. Picone, O. Puechal, O. Rosa-Calatrava, M. Rossignol, B. Rossignol, P. Roy, C. Schneider, M. Su, R. Tardivon, C. Tellier, M.-C. Teoule, F. Terrier, O. Timsit, J.F. Tual, C. Vanel, N. Veislinger, A. Wiedemann, A. Danielson, J.J. Dobbs, K. Kashyap, A. Ding, L. Dalgard, C.L. Sottini, A. Quaresima, V. Quiros-Roldan, E. Rossi, C. Bettini, L.R. D'Angio, M. Beretta, I. Montagna, D. Licari, A. Marseglia, G.L. Storgaard, M. Jorgensen, S. Al-Muhsen, S. Al-Mulla, F. Arias, A.A. Bogunovic, D. Bolze, A. Brodin, P. Bryceson, Y. Bustamante, C.D. Butte, M.J. Chakravorty, S. Christodoulou, J. Constantinescu, S.N. Cooper, M.A. Desai, M. Drolet, B.A. El Baghdadi, J. Espinosa-Padilla, S. Froidure, A. Henrickson, S.E. Hsieh, E.W.Y. Husebye, E.S. Imai, K. Itan, Y. Jarvis, E.D. Karamitros, T. Ku, C.-L. Ling, Y. Lucas, C.L. Maniatis, T. Marodi, L. Milner, J.D. Mironska, K. Novelli, A. Novelli, G. Renia, L. Resnick, I. Sancho-Shimizu, V. Seppanen, M.R.J. Shahrooei, M. Slaby, O. Tayoun, A.A. Ramaswamy, S. Turvey, S.E. Furkan Uddin, K.M. Uddin, M.J. Von Bernuth, H. Zawadzki, P. Bigio, B. De La Chapelle, A. Chen, J. Chrabieh, M. Liu, D. Nemirowskaya, Y. Cruz, I.M. Materna, M. Pelet, S. Seeleuthner, Y. Thibault, C. Liu, Z. Foti, G. Bellani, G. Citerio, G. Contro, E. Pesci, A. Valsecchi, M.G. Cazzaniga, M. Batten, I. Reddy, C. McElheron, M. Noonan, C. Connolly, E. Fallon, A. Erikstrup, C. Pedersen, O.B. Sorensen, E. Mikkelsen, S. Dinh, K.M. Larsen, M.A.H. Paulsen, I.W. Von Stemann, J.H. Hansen, M.B. Annereau, J.-P. Briseno-Roa, L. Gribouval, O. Pelet, A. Alcover, A. Aschard, H. Bousso, P. Bruhns, P. Cerf-Bensussan, N. Cumano, A. D'Enfert, C. Deriano, L. Dillies, M.-A. Di Santo, J. Dromer, F. Eberl, G. Enninga, J. Gomperts-Boneca, I. Hasan, M. Hedestam, G.K. Hercberg, S. Ingersoll, M.A. Lantz, O. Kenny, R.A. Menager, M. Michel, F. Patin, E. Pellegrini, S. Rausell, A. Rieux-Laucat, F. Rogge, L. Fontes, M. Sakuntabhai, A. Schwartz, O. Schwikowski, B. Shorte, S. Tangy, F. Toubert, A. Touvier, M. Ungeheuer, M.-N. Zimmer, C. Albert, M.L. Van Agtmael, M. Algera, A.G. Appelman, B. Van Baarle, F. Bax, D. Beudel, M. Bogaard, H.J. Bomers, M. Bonta, P. Bos, L. Botta, M. De Brabander, J. De Bree, G. De Bruin, S. Buis, D.T.P. Bugiani, M. Bulle, E. Chouchane, O. Cloherty, A. Dijkstra, M. Dongelmans, D.A. Dujardin, R.W.G. Elbers, P. Fleuren, L. Geerlings, S. Geijtenbeek, T. Girbes, A. Goorhuis, B. Grobusch, M.P. Hafkamp, F. Hagens, L. Hamann, J. Harris, V. Hemke, R. Hermans, S.M. Heunks, L. Hollmann, M. Horn, J. Hovius, J.W. De Jong, M.D. Lim, E.H.T. Van Mourik, N. Nellen, J. Nossent, E.J. Paulus, F. Peters, E. Pina-Fuentes, D.A.I. Van Der Poll, T. Preckel, B. Prins, J.M. Raasveld, J. Reijnders, T. De Rotte, M.C.F.J. Schinkel, M. Schultz, M.J. Schrauwen, F.A.P. Schuurman, A. Schuurmans, J. Sigaloff, K. Slim, M.A. Smeele, P. Smit, M. Stijnis, C.S. Stilma, W. Teunissen, C. Thoral, P. Tsonas, A.M. Tuinman, P.R. Van Der Valk, M. Veelo, D. Volleman, C. De Vries, H. Vught, L.A. Van Vugt, M. Wouters, D. Zwinderman, A.H. Brouwer, M.C. Joost Wiersinga, W. Vlaar, A.P.J. Nadif, R. Goldberg, M. Ozguler, A. Henny, J. Lemonnier, S. Coeuret-Pellicer, M. Le Got, S. Tzourio, C. Dufouil, C. Soumare, A. Lachaize, M. Fievet, N. Flaig, A. Martin, F. Bonneaudeau, B. Cannet, D. Gallian, P. Jeanne, M. Perroquin, M. Hamzeh-Cognasse, H. CoV-Contact Cohort St James's Hospital, SARS CoV2 Interest group COVID Clinicians French COVID Cohort Study Group NIAID Immune Response to COVID Group Danish CHGE COVID Human Genetic Effort HGID Lab COVID-STORM Clinicians NH-COVAIR Study Group The Danish Blood Donor Study (DBDS) Imagine COVID-Group The Milieu Interieur Consortium Amsterdam UMC Covid-19 Biobank CONSTANCES cohort 3C-Dijon Study Cerba HealthCare Etablissement du Sang study group

Abstract

Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma diluted 1:10) of IFN-α and/or IFN-ω are found in about 10% of patients with critical COVID-19 (coronavirus disease 2019) pneumonia but not in individuals with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or IFN-ω (100 pg/ml; in 1:10 dilutions of plasma) in 13.6% of 3595 patients with critical COVID-19, including 21% of 374 patients >80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1124 deceased patients (aged 20 days to 99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-β. We also show, in a sample of 34,159 uninfected individuals from the general population, that auto-Abs neutralizing high concentrations of IFN-α and/or IFN-ω are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of individuals carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals 80 years. By contrast, auto-Abs neutralizing IFN-β do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over 80s and total fatal COVID-19 cases. © 2021 The Authors, some rights reserved.

Published
2021

34. How doctors actually (do not) involve families in decisions to continue or discontinue life-sustaining treatment in neonatal, pediatric, and adult intensive care: A qualitative study.

Author

Akkermans, A., Lamerichs, J.M.W.J., Schultz, M.J., Cherpanath, T.G.V., van Woensel, J.B.M., van Heerde, M., van Kaam, A.H.L.C., van de Loo, M.D., Stiggelbout, A.M., Smets, E.M.A., and de Vos, M.A.

Subjects
RESEARCH, LIFE support systems in critical care, NEONATAL intensive care, ACADEMIC medical centers, PHYSICIAN-patient relations, CONVERSATION, FAMILIES, QUALITATIVE research, DECISION making, CRITICAL care medicine, TERMINATION of treatment, THEMATIC analysis
Abstract

Background: Intensive care doctors have to find the right balance between sharing crucial decisions with families of patients on the one hand and not overburdening them on the other hand. This requires a tailored approach instead of a model based approach. Aim: To explore how doctors involve families in the decision-making process regarding life-sustaining treatment on the neonatal, pediatric, and adult intensive care. Design: Exploratory inductive thematic analysis of 101 audio-recorded conversations. Setting/participants: One hundred four family members (61% female, 39% male) and 71 doctors (60% female, 40% male) of 36 patients (53% female, 47% male) from the neonatal, pediatric, and adult intensive care of a large university medical center participated. Results: We identified eight relevant and distinct communicative behaviors. Doctors' sequential communicative behaviors either reflected consistent approaches—a shared approach or a physician-driven approach—or reflected vacillating between both approaches. Doctors more often displayed a physician-driven or a vacillating approach than a shared approach, especially in the adult intensive care. Doctors did not verify whether their chosen approach matched the families' decision-making preferences. Conclusions: Even though tailoring doctors' communication to families' preferences is advocated, it does not seem to be integrated into actual practice. To allow for true tailoring, doctors' awareness regarding the impact of their communicative behaviors is key. Educational initiatives should focus especially on improving doctors' skills in tactfully exploring families' decision-making preferences and in mutually sharing knowledge, values, and treatment preferences. [ABSTRACT FROM AUTHOR]

Published
2021
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37. A multifaceted individualized pneumoperitoneum strategy for laparoscopic colorectal surgery: a multicenter observational feasibility study

Author

Diaz-Cambronero, O., Lorente, B. Flor, Mazzinari, G., Montanes, M. Vila, Gregorio, N. de, Hernandez, D., Arnal, L.E. Olmedilla, Navarro, M.P. Argente, Warle, M.C., Schultz, M.J., Errando, C.L., Intensive Care Medicine, ACS - Diabetes & metabolism, ACS - Pulmonary hypertension & thrombosis, and ACS - Microcirculation

Subjects
Male, medicine.medical_specialty, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Abdominal wall, 03 medical and health sciences, Colonic Diseases, 0302 clinical medicine, Pneumoperitoneum, medicine, Clinical endpoint, Pressure, Humans, Prospective Studies, Laparoscopy, Prospective cohort study, Colectomy, medicine.diagnostic_test, business.industry, Abdominal Cavity, Middle Aged, medicine.disease, Colorectal surgery, Surgery, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Feasibility Studies, 030211 gastroenterology & hepatology, Observational study, Female, business, Pneumoperitoneum, Artificial, Abdominal surgery
Abstract

Item does not contain fulltext BACKGROUND: While guidelines for laparoscopic abdominal surgery advise using the lowest possible intra-abdominal pressure, commonly a standard pressure is used. We evaluated the feasibility of a predefined multifaceted individualized pneumoperitoneum strategy aiming at the lowest possible intra-abdominal pressure during laparoscopic colorectal surgery. METHODS: Multicenter prospective study in patients scheduled for laparoscopic colorectal surgery. The strategy consisted of ventilation with low tidal volume, a modified lithotomy position, deep neuromuscular blockade, pre-stretching of the abdominal wall, and individualized intra-abdominal pressure titration; the effect was blindly evaluated by the surgeon. The primary endpoint was the proportion of surgical procedures completed at each individualized intra-abdominal pressure level. Secondary endpoints were the respiratory system driving pressure, and the estimated volume of insufflated CO2 gas needed to perform the surgical procedure. RESULTS: Ninety-two patients were enrolled in the study. Fourteen cases were converted to open surgery for reasons not related to the strategy. The intervention was feasible in all patients and well-accepted by all surgeons. In 61 out of 78 patients (78%), surgery was performed and completed at the lowest possible IAP, 8 mmHg. In 17 patients, IAP was raised up to 12 mmHg. The relationship between IAP and driving pressure was almost linear. The mean estimated intra-abdominal CO2 volume at which surgery was performed was 3.2 L. CONCLUSION: A multifaceted individualized pneumoperitoneum strategy during laparoscopic colorectal surgery was feasible and resulted in an adequate working space in most patients at lower intra-abdominal pressure and lower respiratory driving pressure. ClinicalTrials.gov (Trial Identifier: NCT03000465).

Published
2019

38. A systematic review and consensus definitions for standardised end-points in perioperative medicine: pulmonary complications

Author

Abbott, T.E.F., Fowler, A.J., Pelosi, P., Gama de Abreu, M., Møller, A.M., Canet, J., Creagh-Brown, B., Mythen, M., Gin, T., Lalu, M.M., Futier, E., Grocott, M.P., Schultz, M.J., Pearse, R.M., Myles, P., Gan, T. J., Kurz, A., Peyton, P., Sessler, D., Tramèr, M., Cyna, A., De Oliveira, G. S., Wu, C., Jensen, M., Kehlet, H., Botti, M., Boney, O., Haller, G., Cook, T., Fleisher, L., Neuman, M., Story, D., Gruen, R., Bampoe, S., Evered, Lis, Scott, D., Silbert, B., van Dijk, D., Kalkman, C., Chan, M., Grocott, H., Eckenhoff, R., Rasmussen, L., Eriksson, L., Beattie, S., Wijeysundera, D., Landoni, G., Leslie, K., Biccard, B., and Howell, S.

Abstract

Background: There is a need for robust, clearly defined, patient-relevant outcome measures for use in randomised trials in perioperative medicine. Our objective was to establish standard outcome measures for postoperative pulmonary complications research. Methods: A systematic literature search was conducted using MEDLINE, Web of Science, SciELO, and the Korean Journal Database. Definitions were extracted from included manuscripts. We then conducted a three-stage Delphi consensus process to select the optimal outcome measures in terms of methodological quality and overall suitability for perioperative trials. Results: From 2358 records, the full texts of 81 manuscripts were retrieved, of which 45 met the inclusion criteria. We identified three main categories of outcome measure specific to perioperative pulmonary outcomes: (i) composite outcome measures of multiple pulmonary outcomes (27 definitions); (ii) pneumonia (12 definitions); and (iii) respiratory failure (six definitions). These were rated by the group according to suitability for routine use. The majority of definitions were given a low score, and many were imprecise, difficult to apply consistently, or both, in large patient populations. A small number of highly rated definitions were identified as appropriate for widespread use. The group then recommended four outcome measures for future use, including one new definition. Conclusions: A large number of postoperative pulmonary outcome measures have been used, but most are poorly defined. Our four recommended outcome measures include a new definition of postoperative pulmonary complications, incorporating an assessment of severity. These definitions will meet the needs of most clinical effectiveness trials of treatments to improve postoperative pulmonary outcomes.

Published
2018

39. Effect of a Low vs Intermediate Tidal Volume Strategy on Ventilator-Free Days in Intensive Care Unit Patients Without ARDS: A Randomized Clinical Trial

Author

Simonis, F.D., Neto, A.S., Binnekade, J.M., Braber, A., Bruin, K.C.M., Determann, R.M., Goekoop, G.J., Heidt, J., Horn, J., Innemee, G., Jonge, E. de, Juffermans, N.P., Spronk, P.E., Steuten, L.M., Tuinman, P.R., Wilde, R.B.P. de, Vriends, M., Abreu, M.G. de, Pelosi, P., Schultz, M.J., Writing Grp PReVENT Investigators, Intensive Care Medicine, Graduate School, ACS - Heart failure & arrhythmias, ANS - Neuroinfection & -inflammation, ACS - Diabetes & metabolism, ACS - Pulmonary hypertension & thrombosis, ACS - Microcirculation, Intensive care medicine, and VU University medical center

Subjects
Adult, Male, ARDS, Critical Illness, Ventilator-Induced Lung Injury, Atelectasis, law.invention, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, law, Intensive care, medicine, Tidal Volume, Humans, Hospital Mortality, Tidal volume, Aged, Respiratory Distress Syndrome, business.industry, Respiration, Medicine (all), Hazard ratio, Environmental air flow, 030208 emergency & critical care medicine, General Medicine, Middle Aged, Outcome and Process Assessment (Health Care), medicine.disease, Intensive care unit, Respiration, Artificial, Intensive Care Units, Editorial Commentary, Female, Respiratory Distress Syndrome, Adult, Respiratory Insufficiency, Ventilator Weaning, Outcome and Process Assessment, Health Care, 030228 respiratory system, Anesthesia, Artificial, business
Abstract

Importance It remains uncertain whether invasive ventilation should use low tidal volumes in critically ill patients without acute respiratory distress syndrome (ARDS). Objective To determine whether a low tidal volume ventilation strategy is more effective than an intermediate tidal volume strategy. Design, Setting, and Participants A randomized clinical trial, conducted from September 1, 2014, through August 20, 2017, including patients without ARDS expected to not be extubated within 24 hours after start of ventilation from 6 intensive care units in the Netherlands. Interventions Invasive ventilation using low tidal volumes (n = 477) or intermediate tidal volumes (n = 484). Main Outcomes and Measures The primary outcome was the number of ventilator-free days and alive at day 28. Secondary outcomes included length of ICU and hospital stay; ICU, hospital, and 28- and 90-day mortality; and development of ARDS, pneumonia, severe atelectasis, or pneumothorax. Results In total, 961 patients (65% male), with a median age of 68 years (interquartile range [IQR], 59-76), were enrolled. At day 28, 475 patients in the low tidal volume group had a median of 21 ventilator-free days (IQR, 0-26), and 480 patients in the intermediate tidal volume group had a median of 21 ventilator-free days (IQR, 0-26) (mean difference, –0.27 [95% CI, –1.74 to 1.19]; P = .71). There was no significant difference in ICU (median, 6 vs 6 days; 0.39 [–1.09 to 1.89]; P = .58) and hospital (median, 14 vs 15 days; –0.60 [–3.52 to 2.31]; P = .68) length of stay or 28-day (34.9% vs 32.1%; hazard ratio [HR], 1.12 [0.90 to 1.40]; P = .30) and 90-day (39.1% vs 37.8%; HR, 1.07 [0.87 to 1.31]; P = .54) mortality. There was no significant difference in the percentage of patients developing the following adverse events: ARDS (3.8% vs 5.0%; risk ratio [RR], 0.86 [0.59 to 1.24]; P = .38), pneumonia (4.2% vs 3.7%; RR, 1.07 [0.78 to 1.47]; P = .67), severe atelectasis (11.4% vs 11.2%; RR, 1.00 [0.81 to 1.23]; P = .94), and pneumothorax (1.8% vs 1.3%; RR, 1.16 [0.73 to 1.84]; P = .55). Conclusions and Relevance In patients in the ICU without ARDS who were expected not to be extubated within 24 hours of randomization, a low tidal volume strategy did not result in a greater number of ventilator-free days than an intermediate tidal volume strategy. Trial Registration ClinicalTrials.gov Identifier:NCT02153294

Published
2018
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40. Associations between positive end-expiratory pressure and outcome of patients without ARDS at onset of ventilation: a systematic review and meta-analysis of randomized controlled trials

Author

Neto, A.S., Rabello, R., Cherpanath, T.G.V., Determann, R., Dongelmans, D. A., Paulus, F., Tuinman, P. R., Pelosi, P., de Abreu, M.G., Schultz, M.J., Investigators, Prove Network, Intensive care medicine, ICaR - Circulation and metabolism, Graduate School, Intensive Care Medicine, AII - Amsterdam institute for Infection and Immunity, and Other Research

Subjects
medicine.medical_specialty, ARDS, medicine.medical_treatment, Hyperinflation, 030204 cardiovascular system & hematology, Critical Care and Intensive Care Medicine, law.invention, Hypoxemia, 03 medical and health sciences, 0302 clinical medicine, Mechanical ventilation, Randomized controlled trial, law, Acute respiratory distress syndrome, Atelectasis, Intensive care unit, Meta-analysis, Positive end-expiratory pressure, medicine, 030212 general & internal medicine, business.industry, Research, respiratory system, medicine.disease, Confidence interval, respiratory tract diseases, Anesthesia, Breathing, Physical therapy, medicine.symptom, business, circulatory and respiratory physiology
Abstract

Background The aim of this investigation was to compare ventilation at different levels of positive end-expiratory pressure (PEEP) with regard to clinical important outcomes of intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) at onset of ventilation. Methods Meta-analysis of randomized controlled trials (RCTs) comparing a lower level of PEEP with a higher level of PEEP was performed. The primary outcome was in-hospital mortality. Results Twenty-one RCTs (1393 patients) were eligible. PEEP ranged from 0 to 10 cmH2O and from 5 to 30 cmH2O in the lower PEEP and the higher PEEP arms of included RCTs, respectively. In-hospital mortality was not different between the two PEEP arms in seven RCTs (risk ratio [RR] 0.87; 95% confidence interval [CI] 0.62–1.21; I 2 = 26%, low quality of evidence [QoE]), as was duration of mechanical ventilation in three RCTs (standardized mean difference [SMD] 0.68; 95% CI −0.24 to 1.61; I 2 = 82%, very low QoE). PaO2/FiO2 was higher in the higher PEEP arms in five RCTs (SMD 0.72; 95% CI 0.10–1.35; I 2 = 86%, very low QoE). Development of ARDS and the occurrence of hypoxemia (2 RCTs) were lower in the higher PEEP arms in four RCTs and two RCTs, respectively (RR 0.43; 95% CI 0.21–0.91; I 2 = 56%, low QoE; RR 0.42; 95%–CI 0.19–0.92; I 2 = 19%, low QoE). There was no association between the level of PEEP and any hemodynamic parameter (four RCTs). Conclusion Ventilation with higher levels of PEEP in ICU patients without ARDS at onset of ventilation was not associated with lower in-hospital mortality or shorter duration of ventilation, but with a lower incidence of ARDS and hypoxemia, as well as higher PaO2/FiO2. These findings should be interpreted with caution, as heterogeneity was moderate to high, the QoE was low to very low, and the available studies prevented us from addressing the effects of moderate levels of PEEP. Electronic supplementary material The online version of this article (doi:10.1186/s13613-016-0208-7) contains supplementary material, which is available to authorized users.

Published
2016
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41. Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

Author

Cheng, S.-C. Scicluna, B.P. Arts, R.J.W. Gresnigt, M.S. Lachmandas, E. Giamarellos-Bourboulis, E.J. Kox, M. Manjeri, G.R. Wagenaars, J.A.L. Cremer, O.L. Leentjens, J. Van Der Meer, A.J. Van De Veerdonk, F.L. Bonten, M.J. Schultz, M.J. Willems, P.H.G.M. Pickkers, P. Joosten, L.A.B. Van Der Poll, T. Netea, M.G.

Abstract

The acute phase of sepsis is characterized by a strong inflammatory reaction. At later stages in some patients, immunoparalysis may be encountered, which is associated with a poor outcome. By transcriptional and metabolic profiling of human patients with sepsis, we found that a shift from oxidative phosphorylation to aerobic glycolysis was an important component of initial activation of host defense. Blocking metabolic pathways with metformin diminished cytokine production and increased mortality in systemic fungal infection in mice. In contrast, in leukocytes rendered tolerant by exposure to lipopolysaccharide or after isolation from patients with sepsis and immunoparalysis, a generalized metabolic defect at the level of both glycolysis and oxidative metabolism was apparent, which was restored after recovery of the patients. Finally, the immunometabolic defects in humans were partially restored by therapy with recombinant interferon-γ, which suggested that metabolic processes might represent a therapeutic target in sepsis. © 2016 Nature America, Inc.

Published
2016

43. Alveolar but Not Intravenous S-Ketamine Inhibits Alveolar Sodium Transport and Lung Fluid Clearance in Rats

Author

Berger, M.M., Pitzer, B., Zugel, S., Wieland, C.W., Vlaar, A.P., Schultz, M.J., Dahan, A., Bartsch, P., Hollmann, M.W., and Mairbaurl, H.

Subjects
fungi, respiratory-distress-syndrome epithelial sodium pulmonary-edema ion-transport guinea-pig blood-flow mechanisms anesthesia channels pharmacokinetics, respiratory system
Abstract

BACKGROUND: S-ketamine is frequently used for analgosedation, especially during sepsis and cardiovascular instability. Because S-ketamine blocks voltage-gated sodium (Na+) channels in neurons and skeletal muscle, it is conceivable that S-ketamine also blocks alveolar epithelial Na+ channels that are crucial for alveolar fluid clearance (AFC). We studied the effects of alveolar and IV S-ketamine on transalveolar Na+ transport and AFC, and investigated whether IV S-ketamine enters the alveolar space in response to endotoxemia-induced pulmonary inflammation. METHODS: Cultured rat alveolar type II (ATII) cells were exposed to S-ketamine and/or the Na+ channel blocker amiloride (100 mu M) and transepithelial transport indicated by short circuit current (ISC) was measured in Ussing chambers. AFC was measured in fluid-instilled lungs of anesthetized rats with or without amiloride added to the instillate. S-ketamine was either added to the instillate or injected IV. To induce mild lung injury that might favor the appearance of IV S-ketamine at the alveolar surface, endotoxemia was induced by IV lipopolysaccharide (7.5 mg/kg). RESULTS: In ATII cells, S-ketamine (25 mu g/mL) caused a decrease of ISC regardless of apical (-18.9%+/- 1.4%; P < 0.001) or basolateral (-20.4%+/- 3.7%; P < 0.001) application. In ATII cells pretreated with amiloride, addition of apical or basolateral S-ketamine did not decrease ISC. AFC was approximately 8% per 30 minutes in control rats. S-ketamine (5 mu g/mL) in the instillate reduced AFC to 1.1%+/- 1.5% (P = 0.04) by decreasing amiloride-sensitive transepithelial Na+ transport. Intravenous S-ketamine (20 mg/kg) did not affect AFC (P = 0.31). In the presence of lipopolysaccharide-induced inflammation, the concentration of IV-injected S-ketamine in bron-choalveolar lavage fluid remained below the concentration that inhibited AFC. CONCLUSIONS: Although exposure of the rat alveolar epithelium to S-ketamine decreases amiloride-sensitive transalveolar Na+ transport and AFC, IV S-ketamine at clinically relevant bolus concentrations does not affect AFC, even in the presence of mild lung injury. (Anesth Analg 2010;111:164-70)

Published
2010

44. Interference by new-generation mobile phones on critical care medical equipment

Author

Lieshout, E.J. van, Veer, S.N. van der, Hensbroek, R., Korevaar, J.C., Vroom, M.B., and Schultz, M.J.

Subjects
Critical Care, Hazards, Ventilators, Electromagnetic fields, Hospitals, Medical instrumentation, Electronics, Medical, Equipment Failure Analysis, Health, Antenna, Statistical analysis, Intensive care, Cellular Phone, Telecommunication, Mobile phone, Equipment and Supplies, Hospital
Abstract

GPRS, UMTS en medische apparatuur in het ziekenhuis

Published
2007

46. Innate immunity against respiratory pathogens

Author

Schultz, M.J., van Deventer, Sander J. H., Speelman, Pieter, van der Poll, Tom, Intensive Care Medicine, van Deventer, S.J.H., Speelman, P., van der Poll, T., and Faculteit der Geneeskunde

Published
2002

47. Protein C in pneumonia

Author

Choi, G., Schultz, M.J., Levi, M., van der Poll, T., Millo, J.L., and Garrard, C.S.

Subjects
Bacterial pneumonia -- Care and treatment, Pneumonia -- Care and treatment, Protein C -- Physiological aspects, Health
Published
2005

50. Transient versus Persistent Acute Kidney Injury and the Diagnostic Performance of Fractional Excretion of Urea in Critically Ill Patients.

Author

Wlodzimirow, K.a., abu-Hanna, a., Royakkers, a.a.N.M., Spronk, P.E., Hofstra, L.S., Kuiper, M.a., Schultz, M.J., and Bouman, C.S.C.

Subjects
CRITICAL care medicine, KIDNEY injuries, ACUTE kidney failure, TUMOR markers, BIOMARKERS, CRITICALLY ill
Abstract

Aims: To evaluate the performance of fractional excretion of urea (FeU) for differentiating transient (T) from persistent (P) acute kidney injury (AKI) and to assess performance of FeU in predicting AKI in patients admitted to the ICU. Methods: We performed secondary analysis of a multicenter prospective observational cohort study on the predictive performance of biological markers for AKI in critically ill patients. AKI was diagnosed according to RIFLE staging. Results: Of 150 patients, 51 and 41 patients were classified as having T-AKI and P-AKI, respectively. The diagnostic performance for FeU to discriminate T-AKI from P-AKI on the day of AKI was poor (AUC-ROC = 0.61; 95% CI: 0.49-0.73). The diagnostic performance of FeU to predict AKI 1 and 2 days prior to AKI was poor as well (AUC-ROC = 0.61; 95% CI: 0.47-0.74, and 0.58; 95% CI: 0.43-0.73, respectively). Conclusions: FeU does not seem to be helpful in differentiating T- from P-AKI in critically ill patients and it is a poor predictor of AKI. © 2014 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2014
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