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The glutamatergic N-methyl-D-aspartate receptor antagonist ketamine produces transient dissociative states and alters cognitive functioning in healthy humans, thus resembling the core symptoms of acute and chronic post-traumatic stress disorder (PTSD). First evidence exists that the common use of the analgesic and sedative properties of ketamine during emergency care correlates with sustained symptoms of PTSD in accident victims. The aim of the present study was to examine whether ketamine administration after moderate accidental trauma modulates dissociation and other symptoms of acute stress disorder (ASD) in the direct aftermath of the event. Accident victims were screened within the third day after admission to hospital for symptoms of ASD (Peritraumatic Dissociative Experiences Questionnaire, ASD Scale) and prior stressful life events (Traumatic Life Events Questionnaire). Subjects had received a single or fractionated dose of either racemic ketamine (n = 13), opioids (n = 24) or non-opioid analgesics (n = 13) during initial emergency treatment. There were no significant differences between medication groups in demographic and clinical characteristics such as injury severity or prior traumatization. With respect to ASD symptomatology three days post-event there were significant associations between ketamine analgosedation and increased symptoms of dissociation, reexperiencing, hyperarousal and avoidance relative to the comparison groups. Growing evidence exists that ketamine might modulate or aggravate early post-traumatic stress reactions when given in the acute trauma phase, which in turn might contribute to long-lasting symptomatology. [ABSTRACT FROM AUTHOR]

Background: Altered affective state recognition is assumed to be a root cause of aggressive behavior, a hallmark of psychopathologies such as psychopathy and antisocial personality disorder. However, the two most influential models make markedly different predictions regarding the underlying mechanism. According to the integrated emotion system theory (IES), aggression reflects impaired processing of social distress cues such as fearful faces. In contrast, the hostile attribution bias (HAB) model explains aggression with a bias to interpret ambiguous expressions as angry., Methods: In a set of four experiments, we measured processing of fearful and angry facial expressions (compared to neutral and other expressions) in a sample of 65 male imprisoned violent offenders rated using the Hare Psychopathy Checklist-Revised (PCL-R, Hare, R. D. (1991). The psychopathy checklist-revised . Toronto, ON: Multi-Health Systems) and in 60 age-matched control participants., Results: There was no evidence for a fear deficit in violent offenders or for an association of psychopathy or aggression with impaired processing of fearful faces. Similarly, there was no evidence for a perceptual bias for angry faces linked to psychopathy or aggression. However, using highly ambiguous stimuli and requiring explicit labeling of emotions, violent offenders showed a categorization bias for anger and this anger bias correlated with self-reported trait aggression (but not with psychopathy)., Conclusions: These results add to a growing literature casting doubt on the notion that fear processing is impaired in aggressive individuals and in psychopathy and provide support for the idea that aggression is related to a hostile attribution bias that emerges from later cognitive, post-perceptual processing stages.

Deficits in facial emotion recognition have frequently been established in temporal lobe epilepsy (TLE). However, static, rather than dynamic emotion recognition paradigms have been applied. Affective prosody has been insufficiently studied in TLE, and there is a lack of studies investigating associations between auditory and visual emotion recognition. We wished to investigate potential deficits in a dynamic morph task of facial emotion recognition and in an affective prosody recognition task, as well as associations between both tasks. 25 patients with TLE and 24 healthy controls (CG) performed a morph task with faces continuously changing in their emotional intensity. They had to press a button, as soon as they were able to recognize the emotion expressed, and label it accordingly. In the auditory task, subjects listened to neutral sentences spoken in varying emotional tones, and labeled the emotions. Correlation analyses were conducted across both tasks. TLE patients showed significantly reduced prosody recognition compared to CG, and in the morph task, there was a statistical trend towards significantly reduced performance for TLE. Recognition rates in both tasks were significantly associated. TLE patients show deficits in affective prosody recognition, and they may also be impaired in a morph task with dynamically changing facial expressions. Impairments in basic social-cognitive tasks in TLE seem to be modality-independent., (© 2024. The Author(s).)

Background: Eye-movement patterns during facial emotion recognition are under-researched in patients with focal epilepsy (PWFE). Previous studies including other neurological patients indicate that bilateral mesiotemporal damage could be associated with impaired emotion recognition and abnormal eye-movement patterns., Aims: The current study addresses the question whether PWFE, in whom fronto-(mesio-)temporal networks are often disturbed, also show abnormal eye-movement patterns during facial emotion recognition., Method: 24 PWFE and a group of 29 healthy controls (HC) performed a facial emotion recognition task and a gender recognition task while eye movements were recorded with an eye-tracker. For this purpose, Areas of Interest (AOI) were defined in the presented faces: the eye region and the mouth region. In addition to the proportion of correctly recognized emotions, the following eye-tracking parameters were recorded: Relative fixation duration (FD)/fixation count (FC) in the mouth region/eye region (relative to the FD/FC on the entire screen)., Results: PFWE showed an emotion recognition deficit compared to HC, whereas gender recognition performance did not differ between groups. In addition, PWFE showed significantly fewer and shorter fixations in the mouth region than HC, in both the emotion recognition task and the gender recognition task., Conclusions: When looking at faces, PFWE show eye-movement patterns different from those of healthy controls. Behaviorally, PWFE are only impaired in emotion recognition. Hence, PWFE possibly scan facial regions that are relevant to successful emotion recognition more diffusely and less efficiently than healthy control subjects. Future studies should investigate the etiology of such abnormal eye-movement patterns in PWFE., (Copyright © 2022 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.)

Objective: Social cognition comprises basic and more complex functions, such as theory of mind (ToM) and affective empathy. Although everyday social interactions may be impaired if such higher-order social cognitive functions are compromised, associations between social functioning and social cognition in people with focal epilepsy (PWFE) are still poorly understood. We used a novel, naturalistic approach to investigate ToM in PWFE by applying the Movie for the Assessment of Social Cognition (MASC). Furthermore, we studied affective empathy, the relationship between social cognitive parameters and measures of social functioning, as well as between epilepsy focus and ToM., Methods: Thirty patients with either temporal (TLE) or frontal lobe epilepsy (FLE) were compared to 29 healthy control subjects (HC). In addition to the MASC, we applied questionnaire measures assessing empathy and everyday social functioning., Results: PWFE, especially with FLE, performed significantly worse than HC on the MASC. Perceived social integration and social activities, but not affective empathy, were reduced in PWFE. Regression analyses revealed associations between perceived social integration, clinical group status, affective empathy and ToM., Conclusion: PWFE displayed ToM deficits during a naturalistic task, whereas affective empathy was unimpaired. FLE may be associated with especially compromised ToM performance. Social cognition and social functioning appear to be interrelated in PWFE, whose self-perceived levels of social integration and social activities are lower than those of HC. More research into the association between social cognition and social functioning in PWFE is needed, in order to develop tailored intervention programs for these patients., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Metternich, Wagner, Geiger, Schulze-Bonhage, Hirsch and Schönenberg.)

Affective state recognition and in particular the identification of fear is known to be impaired in psychopathy. It is unclear, however, whether this reflects a deficit in basic perception ('fear blindness') or a deficit in later cognitive processing. To test for a perceptual deficit, 63 male incarcerated offenders, assessed with the Hare Psychopathy Checklist-Revised (PCL-R), detected fearful, neutral, and happy facial expressions rendered invisible through continuous flash suppression (CFS). Fearful faces were detected faster than neutral and happy faces. There was no reduction of the fear advantage in the 20 offenders diagnosed with psychopathy according to the PCL-R, and there was no correlation between the fear advantage and PCL-R scores. Deficits in the processing of fearful facial expressions in psychopathy may thus not reflect fear blindness, but impairments at later postperceptual processing stages. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

While norm-violating behavior in antisocial individuals has been widely studied, little is known about how these people react to unfair behavior directed towards them. Previous research yields inconclusive results with some evidence for rational and strategic behavior in antisocial individuals. Electrophysiological correlates as well as socio-contextual factors such as group affiliation that may inform decision making on fairness considerations have not been investigated in previous studies. This study compared fairness considerations of antisocial violent offenders (N = 25) and controls (N = 26) by using the Ultimatum Game where one player proposes a split of resources and the other player has to respond by accepting or declining the offer. Group affiliation of the proposer (in- vs. out-group) and fairness of offers (fair vs. unfair) were manipulated. We found no difference between groups regarding decision behavior. However, healthy participants showed an electrophysiological response to group affiliation, which was attenuated in the violent offender group. This data suggests intact understanding of social norms in antisocial violent offenders while electrophysiological response pattern may be linked to impaired emotional reactions to expectancy violations., (Copyright © 2021 Elsevier Inc. All rights reserved.)

Antisocial and psychopathic individuals are characterized by a reduced responsivity to affective information. Yet, the role of attentional processes as possible modulator of these deficits is poorly understood. The current study investigated early and late processing of emotional stimuli in a sample of incarcerated offenders while manipulating the attentional focus. Twenty-seven male violent offenders with psychopathic traits and 27 healthy controls completed two experimental tasks while electroencephalography (EEG) data were collected. Task 1 assessed indirect processing of emotional or neutral distractors during a perceptual judgment task, while Task 2 measured direct processing of the emotional or neutral stimuli and required participants to rate the stimuli regarding valence and arousal. EEG data indicated no differences in early stage processing (early posterior negativity) between the experimental groups. However, we found significant group differences with regard to the late processing stage (late positive potential, LPP). Controls showed increased LPP amplitudes in Task 2 as compared to Task 1, indicating that task demands (i.e., attentional focus) had an effect on the processing of the emotional stimuli. In contrast, LPP amplitudes in the violent offender group were largely unaffected by task demands, suggesting specific late alterations in the neural processing of emotional stimuli. In sum, this study provides new evidence for a modulatory impact of attention on affective information processing in male violent offenders with psychopathic traits., (© 2021 The Authors. Journal of Neuroscience Research published by Wiley Periodicals LLC.)

Attention to the eyes and eye contact form an important basis for the development of empathy and social competences including prosocial behavior. Thus, impairments in attention to the eyes of an interaction partner might play a role in the etiology of antisocial behavior and violence. For the first time, the present study extends investigations of eye gaze to a large sample (N = 173) including not only male but also female violent offenders and a control group. We assessed viewing patterns during the categorization of emotional faces via eye tracking. Our results indicate a reduced frequency of initial attention shifts to the eyes in female and male offenders compared to controls, while there were no general group differences in overall attention to the eye region (i.e., relative dwell time). Thus, we conclude that violent offenders might be able to compensate for deficits in spontaneous attention orienting during later stages of information processing., (Copyright © 2021 Elsevier B.V. All rights reserved.)

In neurofeedback applications, neural activity is recorded, processed in real-time and fed back to the user in order to facilitate self-regulation of the putative neural mechanisms that underlie cognition and behavior. Numerous studies suggest that neurofeedback interventions are an efficacious treatment particularly for patients with attention-deficit/hyperactivity disorder (ADHD). In recent years, however, findings of several well-controlled studies raised doubts concerning the proposed mechanism of action behind the behavioral effect of neurofeedback. This study investigated the impact of expectation on the efficacy of a sensorimotor rhythm (SMR) training. In a within-subjects design 30 blinded volunteers with ADHD symptoms received a standard SMR training session after inducing no (no-expectancy condition), positive (placebo condition), and negative (nocebo condition) expectations regarding the effectiveness of neurofeedback (by telling them that they would train a specific frequency band that was previously shown to be either unrelated to attention, should improve attention, or interfere with attentional processes). After each training, participants were presented with a cognitive test and subsequently requested to rate their performance on it. We could show that participants were able to successfully modify their EEG signal during training. Further, we found an effect over trainings on objective attentional performance. Most importantly, we found that the expectancy of positive or negative treatment effects considerably changed participants' perception of neurofeedback's efficacy even in the absence of any objective evidence. This study presents strong first evidence for a substantial effect of self-confirming response expectancies as one factor underlying the efficacy of neurofeedback. Future research has to carefully consider the impact of such psychosocial mechanisms when evaluating the (specific) efficacy of neuromodulatory treatments., (Copyright © 2020 Elsevier Inc. All rights reserved.)

Psychopathy is characterized by a lack of empathy, callousness, and a range of severe antisocial behaviors. A deficit to accurately process social cues, which has been widely documented in psychopathic populations, is assumed to underlie their pathological development. Impaired attention to socially salient cues, such as the eyes of an interaction partner, is a possible mechanism compromising the development of social cognition. Preliminary evidence from static facial stimuli suggests that psychopathy is indeed linked to reduced eye gaze. However, no study to date has investigated whether these mechanisms apply to naturalistic interactions. This study is the first to examine patterns of visual attention during live social interactions and their association with symptom clusters of psychopathy. Eye contact was assessed in a sample of incarcerated offenders ( N = 30) during semistructured face-to-face interactions with a mobile eye-tracking headset and analyzed using a novel automated areas of interest (e.g., eye region) labeling technique. The interactions included an exchange on neutral predetermined topics and included a condition in which the participants were active (talking) and passive (listening). The data reveal that across both listening and talking conditions higher affective psychopathy is a significant predictor of reduced eye contact (listening: r = -.39; talking: r = -.43). The present findings are in line with previous research suggesting impaired attention to social cues in psychopathy. This study is the first to document these deficits in naturalistic, live social interaction and therefore provides important evidence for their relevance to real-life behavior. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Attention-deficit/hyperactivity disorder (ADHD) has been often referred to as an executive function deficit disorder with a specific electrophysiological signature. Although previous research suggests that individuals with subthreshold symptoms also suffer from severe impairments in daily life, only few studies have investigated cognitive and neural alterations in this group. Here, we explored impairments in executive functions and their electrophysiological correlates in a sample of adults with full syndrome (N = 113) and subthreshold (N = 46) ADHD compared to controls (N = 42). Results suggest that adults with full syndrome ADHD exhibit more executive function deficits than controls, while there were no electrophysiological differences found between groups. Also, we observed only small differences in neuropsychological variables between subthreshold ADHD and controls and no evidence for altered neural activity in the resting state. While subthreshold ADHD was not associated with altered executive functions or abnormal electrophysiological activity, this group reported significant psychological impairments and comorbidity., Competing Interests: Declaration of competing interest The authors also declare that they have no conflicts of interest., (Copyright © 2020 Elsevier Ltd. All rights reserved.)

Neurofeedback has begun to attract the attention and scrutiny of the scientific and medical mainstream. Here, neurofeedback researchers present a consensus-derived checklist that aims to improve the reporting and experimental design standards in the field., (© The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain.)

Antisocial personality disorder is characterized by a stable, lifelong pattern of disregard for and violation of others' rights. Disruptions in the representation of fairness norms may represent a key mechanism in the development and maintenance of this disorder. Here, we investigated fairness norm considerations and reactions to their violations. To examine electrophysiological correlates, we assessed the medial frontal negativity (MFN), an event-related potential previously linked to violations of social expectancy and norms. Incarcerated antisocial violent offenders (AVOs, n = 25) and healthy controls (CTLs, n = 24) acted as proposers in the dictator game (DG) and ultimatum game (UG) and received fair vs. unfair UG offers from either another human (social context) or a computer (non-social context). Results showed that AVOs made lower offers in the DG but not the UG, indicating more rational and strategic behavior. Most importantly, when acting as recipients in the UG, acceptance rates were modulated by social context in CTLs, while AVOs generally accepted more offers. Correspondingly, ERP data indicated pronounced MFN amplitudes following human offers in CTLs, whereas MFN amplitudes in AVOs were generally reduced. The current data suggest intact fairness norm representations but altered reactions to their violation in antisocial personality disorder.

In addition to impairments in cognitive functioning, attention-deficit/hyperactivity disorder (ADHD) is associated with deficits in interpersonal functioning as well which are assumed to stem from a distorted perception or interpretation of affective information. While previous research suggests that the decoding of negatively valenced facial stimuli is impaired, less is known about the potential interpretation biases in ADHD which are linked to other externalizing psychopathologies. The present study investigated interpretation biases in adults with ADHD (N = 65) and controls (N = 49) using ambiguous facial stimuli (angry/happy, angry/fearful, fearful/happy blends) with different proportions of each emotion. Participants indicated the dominant emotion and rated the perceived intensity of each image. While impaired processing of fearful expressions was evident in the ADHD group, the results of the current study do not provide support for an interpretation bias in adults with ADHD. These findings suggest that interpretation biases may be restricted to aggressive psychopathology and cannot be generalized to individuals with ADHD.

Objective: Functional abdominal pain (AP) is a prevalent issue in childhood and adolescence. The contribution of psychosocial factors in the development and maintenance of this health problem is rather unclear, and experimental studies about underlying mechanisms are lacking. This study investigates whether experimentally induced social exclusion decreases sensory and pain thresholds in children suffering from AP., Subjects: Twenty children/adolescents with AP and 22 healthy controls., Methods: Children/adolescents participated in the Cyberball paradigm, which affects an experience of social exclusion. Thermal sensory and pain thresholds were measured before and after Cyberball., Results: Children/adolescents with AP showed a divergent reaction regarding their sensory threshold after social exclusion: The control group exhibited a tendency toward a decreased sensory threshold whereas the AP group remained stable. Concerning the pain threshold, no effect of social exclusion could be identified. The increase of both thresholds ("numbing") after Cyberball was positively correlated with symptoms of mental health issues., Conclusions: This is the first study to investigate changes in sensory and pain thresholds following painful social interactions in a sample of children/adolescents with a chronic pain condition. Results suggest that AP and control children differ in their reaction of sensory thresholds, which might indicate an altered processing of social exclusion. Replication and further methodological improvements are needed., (© 2018 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Attention orienting to socially salient cues, such as the eyes of interaction partners, is assumed to be crucial for the development of intact social cognition. Dysfunctions in such basic processes that guide the perception of social cues have been suggested to play a role in the development of psychopathy. The present study investigated gaze patterns in two groups of incarcerated psychopathic and non-psychopathic offenders. While recording their eye movements, participants were asked to categorize either gender (task 1) or emotional expression (task 2) of facial images. Psychopaths exhibited significantly reduced attention orienting toward the eyes, as indicated by absolute dwell time as well as frequency of the initial fixation on the eye region. This pattern was evident across all emotional expressions and independent of the task. The present results suggest a pervasive impairment to attention orienting toward the eyes in psychopaths compared to non-psychopathic offenders. This impairment appears to affect not only general attention but also early attention shifts. Thus, our findings provide evidence that these dysfunctions might particularly contribute to the development of psychopathy instead of antisocial behavior per se. Future studies should further examine the origin, emergence, and consequences of these impairments in order to develop targeted interventions., (Copyright © 2019 Elsevier Ltd. All rights reserved.)

Objective: ADHD has been repeatedly linked to problems in social functioning. Although some theories assume that the emotion recognition deficits are explained by general attentional deficits, mounting evidence suggests that they may actually constitute a distinct impairment. However, it remains unclear whether the deficient processing affects specific emotional categories or may generalize to all basic emotions. The present study aims to investigate these questions by assessing the sensitivity to all six basic emotions in adults with ADHD., Method: The participants judged the emotion onset in animated morph clips displaying facial expressions that slowly changed from neutral to emotional., Results: ADHD participants exhibited an impaired recognition of sad and fearful facial expressions., Conclusion: The present findings indicate that ADHD is possibly associated with a specific deficit in the recognition of facial emotions signaling negative social feedback.

Conduct disorder is characterized by both habitual aggression as well as non-aggressive rule-breaking behavior. While a large body of research has focused on aggressive behavior to date, the subtype of non-aggressive rule-breaking behavior is poorly understood. The current study represents a first attempt to directly assess decision biases toward rule-breaking behavior, their motivational salience, and the association with interpersonal factors in conduct disorder. Participants (n = 20 children with conduct disorder and n = 20 healthy controls) played a video game with the goal to deliver a hot pizza by bicycle to a marked location on a two-dimensional city map. In each trial, participants decided whether to use the regular route (streets) or opt for a potential shortcut that was either permitted (bicycle lane) or prohibited (park). The efficiency of the shortcut was parametrically varied to assess individual decision functions. Consistent with our hypotheses, group differences emerged only when taking a shortcut represented a rule violation (park condition), with the conduct disorder group committing significantly more rule violations than controls. Furthermore, conduct disorder children showed a substantial frequency of rule violations even in the absence of shortcut related gains, indicating a pronounced insensitivity towards sanctions. Importantly, this tendency was associated with self-reported impulsivity and rule violations in real life., (Copyright © 2018. Published by Elsevier B.V.)

Background: Cognitive deficits including impaired information processing speed as assessed by the Symbol Digit Modalities Test (SDMT) are common in multiple sclerosis (MS). Oscillatory markers of processing speed may be extracted from magnetoencephalographic (MEG) and electroencephalographic (EEG) resting-state recordings. In this context, an increased proportion of frontal slow-wave (theta, 4-8 Hz) to fast-wave (beta, 13-30 Hz) EEG activity was indicative of impaired SDMT performance. Such an increased theta/beta ratio may reflect oscillatory slowing associated with deficits in attention control. Therapeutic approaches that consider atypical oscillatory activity in MS remain sparse., Objectives: In a cross-sectional design, we examined the relation between SDMT performance, the EEG theta/beta ratio and its components. We also explored longitudinally, whether EEG neurofeedback could be used to induce a putatively adaptive alteration in these EEG parameters, toward a pattern indicative of improved processing speed., Methods: N = 58 MS patients (RRMS/SPMS/PPMS N: 18/35/3, 2 cases excluded) participated in a neuropsychological examination and a resting-state EEG recording. Subsequently, N = 10 patients received neurofeedback training for two weeks in a hospitalized setting. The purpose was to reduce the frontal theta/beta ratio through operant conditioning., Results: In the cross-sectional examination, patients with slow SDMT speed displayed an increased theta/beta ratio, relative to those with normal speed. This involved increased frontal theta power, whereas beta power was equal across groups. The theta/beta ratio remained stable during neurofeedback across sessions of the two-week training period. In an exploratory secondary analysis, within sessions a reduction in the theta/beta ratio during active training blocks relative pre/post session resting-states was observed, driven by reduced theta power., Conclusions: These findings provide support for utilizing frontal EEG theta activity as an inverse marker of processing speed in MS. Across sessions, there was no support for successful operant conditioning of the theta/beta ratio during the two-week training period. The observed state-specific shift within sessions, involving a transient reduction in theta activity, nevertheless may provide a rationale for a further investigation of neurofeedback as a treatment approach in MS., (Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.)

Antisocial and psychopathic personality traits constitute a severe and treatment resistant form of externalizing psychopathology. While deficits in social information processing have been extensively investigated in these individuals, less is known about their capacity for altruism and cooperation. In particular, no studies to date have investigated whether established social-contextual determinants of cooperation, e.g., group affiliation and number of expected interactions, can motivate cooperative behaviour in antisocial individuals. The present study compared cooperative behaviour of incarcerated violent offenders (N = 52) and controls (N = 46) by using an established social interaction paradigm (Give Some Dilemma) where two players divide monetary units between themselves and the counterpart. Group affiliation (in- vs. out-group) and number of expected interactions (single-trial vs. repeated-trial interactions) were manipulated. Violent offenders as compared to controls shared less monetary units with their counterparts, indicating an overall reduced cooperation. Both groups showed increased cooperation rates towards in-group members and in repeated interactions. Higher psychopathic traits were associated with lower cooperation in single-trial interactions in the violent offender group. Although cooperation was comparably reduced in violent offenders, behaviour in both groups was determined by the number of expected interactions as well as group affiliation, thus providing evidence for equivalent social-contextual determinants.

Deficiencies in empathic functioning are considered a core characteristic of violent behavior. Enhancing empathy in aggressive populations may thus represent a promising intervention target. Hence, the aims of the present work were two-fold: First, we wanted to thoroughly assess empathic competencies and second, we aimed to investigate effects of an empathy induction on experienced empathy levels and prosocial behavior in a sample of violent offenders relative to matched controls. Empathy was assessed using both self-report as well as objective measures. For the empathy induction, participants were presented with empathy inducing and control videos. To assess the effects of the empathy induction on behavior, participants played a dictator game indicative of prosocial behavior after every video. Violent offenders showed no systematic impairment in empathy measures. Despite lower shares in the dictator game across conditions, the empathy induction led to a substantial increase in prosocial behavior in both groups. Importantly, high psychopathy scores were distinctively associated with lower self-reported empathy levels, an attenuated affective responsiveness to the empathy induction, and less altruistic behavior. Treatment programs aiming to improve empathy should take individual characteristics into account and may be applied to distinctive subgroups rather than to violent offenders per se., (Copyright © 2018. Published by Elsevier B.V.)

Attention deficit and hyperactivity disorder (ADHD) is a prevalent childhood disorder that is often maintained throughout the development and persists into adulthood. Established etiology models suggest that deficient inhibition underlies the core ADHD symptoms. While experimental evidence for impaired motor inhibition is overwhelming, little is known about the sensory inhibition processes, their changes throughout the development, and the relationship to ADHD symptoms. Here, we used the well-established binocular rivalry (BR) paradigm to investigate for the very first time the inhibitory processes related to visual perception in adults with ADHD. In BR, perception alternates between two dichoptically presented images throughout the viewing period, with shorter dominant percept durations and longer transition periods indicating poorer suppression/inhibition. Healthy controls (N = 28) and patients with ADHD (N = 32) were presented with two dissimilar images (orthogonal gratings) separately to each eye through a mirror stereoscope and asked to report their perceptual experiences. There were no differences between groups in any of the BR markers. However, an association between transition durations and symptom severity emerged in the ADHD group. Importantly, an exploratory multiple regression analysis revealed that inattention symptoms were the sole predictor for the duration of transition periods. The lack of impairments to sensory inhibition in adult, but not pediatric ADHD may reflect compensatory changes associated with development, while a correlation between inhibition and inattention symptoms may reveal an invariant core of the disorder.

The cognitive mechanisms of increased distractibility in attention-deficit/hyperactivity disorder (ADHD) are poorly understood. The current study investigated the influence of two major modulating factors (emotional saliency, task difficulty) on behavioral and electrophysiological parameters underlying distractibility in ADHD. In addition, the attentional focus (indirect and direct processing of distractors) was examined. Thirty-six adults with ADHD and 37 healthy controls completed two experimental tasks while electroencephalography (EEG) data was collected. Task 1 assessed indirect processing of emotional or neutral distractors during a perceptual judgment task with varying task difficulty. Task 2 measured direct processing of the emotional or neutral stimuli and required participants to rate the stimuli regarding valence and arousal. Results showed that adults with ADHD exhibited generally higher behavioral distractibility than healthy controls. Furthermore, the ADHD group exhibited an enhanced bottom-up processing [increased early posterior negativity (EPN) amplitudes] of distractors in trials with high task difficulty as well as enhanced top-down processing [increased late positive potential (LPP) amplitudes] in trials with low task difficulty. However, no group differences were evident in the neural processing of emotional content or between attentional focus conditions. These findings support the notion that distractibility in ADHD results from impairments to both top-down as well as bottom-up processes and underscore the importance of task difficulty as a modulating factor., (Copyright © 2018 Elsevier Ltd. All rights reserved.)

Based on the approach-withdrawal model of hemispheric asymmetry, anger and aggression have been linked to an approach-related pattern, characterized by stronger relative left-hemispheric anterior cortical activity. Recent work suggests that also in individuals with extremely violent tendencies, such as imprisoned offenders, approach-related asymmetry may be associated with self-reported trait anger and aggression. A putative association between alpha asymmetry and further characteristics relevant for aggression, such as callous-unemotional (CU) traits, remains to be explored. CU traits may increase the probability of aggressive behavior; nevertheless, they may also enable individuals to inhibit and postpone the overt display of aggression until circumstances grant its strongest impact. In the current exploratory study, we measured trait aggression, CU traits, and resting-state EEG asymmetry in the alpha band (8-13 Hz) in imprisoned violent offenders in a German high security prison. Results revealed that particularly trait callousness was associated with stronger relative right-hemispheric anterior cortical activity (i.e., a withdrawal-related pattern). An association between alpha asymmetry and aggression was not replicated. These preliminary findings suggest that, due to the involved emotional and interpersonal detachment, callousness might be withdrawal related, despite its potential to bring about aggressive behavior. They also imply that the identification of putative clinical subtypes in prisoners is required, as varying psychopathology might undermine an association between alpha asymmetry and aggression., (© 2017 Society for Psychophysiological Research.)

A growing body of literature suggests that ADHD is associated with emotion recognition impairments that may be linked to deficient interpersonal functioning. However, our understanding of the mechanisms underlying these recognition impairments is extremely limited. Here, we used dynamic stimuli to investigate whether impaired emotion recognition in children with ADHD may be associated with impairments in perceptual sensitivity. Participants (ADHD: N = 26; Controls: N = 26) viewed video sequences of neutral faces slowly developing into one of the six basic emotional expressions (angry, happy, fearful, sad, disgusted and surprised) and were instructed to indicate via a button press the precise moment at which they were able to correctly recognize the emotional expression. The results showed that compared to controls, children with ADHD exhibited lower accuracy rates across all emotional expressions while there was no evidence for impaired perceptual sensitivity. Thus, the study provides evidence for a generalized categorization impairment across all emotional categories and is consistent with developmental delay accounts of ADHD. Future studies are needed in order to further investigate the developmental course of social cognition deficits in ADHD., (Copyright © 2017 Elsevier B.V. All rights reserved.)

Objective: Neurophysiologic monitoring parameters related to cognition in Multiple Sclerosis (MS) are sparse. Previous work reported an association between magnetoencephalographic (MEG) alpha-1 activity and information processing speed. While this remains to be replicated by more available electroencephalographic (EEG) methods, also other established EEG markers, e.g. the slow-wave/fast-wave ratio (theta/beta ratio), remain to be explored in this context., Methods: Performance on standard tests addressing information processing speed and attention (Symbol-Digit Modalities Test, SDMT; Test of Attention Performance, TAP) was examined in relation to resting-state EEG alpha-1 and alpha-2 activity and the theta/beta ratio in 25MS patients., Results: Increased global alpha-1 and alpha-2 activity and an increased frontal theta/beta ratio (pronounced slow-wave relative to fast-wave activity) were associated with lower SDMT processing speed. In an exploratory analysis, clinically impaired attention was associated with a significantly increased frontal theta/beta ratio whereas alpha power did not show sensitivity to clinical impairment., Conclusions: EEG global alpha power and the frontal theta/beta ratio were both associated with attention. The theta/beta ratio involved potential clinical sensitivity., Significance: Resting-state EEG recordings can be obtained during the routine clinical process. The examined resting-state measures may represent feasible monitoring parameters in MS. This notion should be explored in future intervention studies., (Copyright © 2017 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.)

Classic findings on conformity and obedience document a strong and automatic drive of human agents to follow any type of rule or social norm. At the same time, most individuals tend to violate rules on occasion, and such deliberate rule violations have recently been shown to yield cognitive conflict for the rule-breaker. These findings indicate persistent difficulty to suppress the rule representation, even though rule violations were studied in a controlled experimental setting with neither gains nor possible sanctions for violators. In the current study, we validate these findings by showing that convicted criminals, i.e., individuals with a history of habitual and severe forms of rule violations, can free themselves from such cognitive conflict in a similarly controlled laboratory task. These findings support an emerging view that aims at understanding rule violations from the perspective of the violating agent rather than from the perspective of outside observer.

Background: Many studies suggest that electroencephalographic (EEG) neurofeedback might be beneficial in the treatment of attention-deficit hyperactivity disorder (ADHD). However, numbers of well controlled studies are low and neurofeedback techniques are regarded as highly controversial. The present trial examined the efficacy (compared with sham neurofeedback) and efficiency (compared with meta-cognitive therapy) of a standard EEG neurofeedback protocol in adults with ADHD., Methods: We did a concurrent, triple-blind, randomised, controlled trial using authorised deception in adults with ADHD from one centre (University of Tübingen) in Tübingen, Germany. Participants were eligible if they fulfilled the DSM-IV-TR criteria for ADHD, were aged between 18 years and 60 years, and had no or stable use of medication for at least 2 months with no intention to change. We excluded participants who had comorbid schizophrenia or schizoaffective disorder, bipolar disorder, borderline personality disorder, epilepsy, or traumatic brain injury; substance abuse or dependence; or current or planned other psychological treatment. Those eligible were randomly assigned to three groups: a neurofeedback group which received 30 verum θ-to-β neurofeedback sessions over 15 weeks, a sham neurofeedback group which received 15 sham followed by 15 verum θ-to-β neurofeedback sessions over 15 weeks, or a meta-cognitive group therapy group which received 12 sessions over 12 weeks. Participants were assigned equally to one of the three interventions through a computerised minimisation randomisation procedure stratified by sex, age, and baseline symptom severity of ADHD. Participants were masked as to whether they were receiving neurofeedback or sham neurofeedback, but those receiving meta-cognitive therapy were aware of their treatment. Clinical assessors (ie, those assessing outcomes) and research staff who did the neurofeedback training were masked to participants' randomisation status only for neurofeedback and sham neurofeedback. The primary outcome was symptom score on the Conners' adult ADHD rating scale, assessed before treatment, at midtreatment (after 8 weeks), after treatment (after 16 weeks), and 6 months later. All individuals with at least one observation after randomisation were included in the analyses. This trial is registered with ClinicalTrials.gov, number NCT01883765., Findings: Between Feb 1, 2013, and Dec 1, 2015, 761 people were assessed for eligibility. 656 (86%) were excluded and 118 (15%) were eligible for participation in this study. Eligible participants were randomly assigned to neurofeedback (38 [32%]), sham neurofeedback (39 [33%]), or meta-cognitive therapy (41 [35%]). 37 (97%) individuals for neurofeedback, 38 (97%) for sham neurofeedback, and 38 (93%) for meta-cognitive therapy were included in analyses. Self-reported ADHD symptoms decreased substantially for all treatment groups (B=-2·58 [95% CI -3·48 to -1·68]; p<0·0001) between pretreatment and the end of 6 month follow-up, independent of treatment condition (neurofeedback vs sham neurofeedback B=-0·89 [95% CI -2·14 to 0·37], p=0·168; neurofeedback vs meta-cognitive therapy -0·30 [-1·55 to 0·95], p=0·639). No treatment-related or trial-related serious adverse events were reported., Interpretation: Our findings suggest that neurofeedback training is not superior to a sham condition or group psychotherapy. All three treatments were equivalently effective in reducing ADHD symptoms. This first randomised, sham-controlled trial did not show any specific effects of neurofeedback on ADHD symptoms in adults., Funding: German Research Foundation., (Copyright © 2017 Elsevier Ltd. All rights reserved.)

Objective: Peer victimization (e.g. social exclusion) has been shown to be associated with physical health problems such as functional somatic complaints and especially symptoms of pain. To date, no study has investigated the mechanisms underlying this association in clinical pediatric samples. The aim of this study was to evaluate the parasympathetic activity during a social exclusion experience in adolescents with functional abdominal pain (FAP)., Methods: Twenty adolecents with FAP and 21 matched healthy participants were compared regarding parameters of parasympathetic activation before, during, and after participating in the Cyberball-game, a well-established paradigm to induce social exclusion., Results: Adolescents with FAP showed an increase in parasympathetic activation during both consecutive phases of the Cyberball game (inclusion as well as exclusion condition) whereas the healthy control group remained stable. There were no differences in subjective experience of in- and exclusion between the groups., Conclusion: The parasympathetic activation pattern may indicate altered processing of social stimuli in adolescents with FAP., (Copyright © 2017 Elsevier Inc. All rights reserved.)

A model of the main sequence is proposed based on the logistic function. The model's fit to the peak velocity-amplitude relation resembles an S curve, simultaneously allowing control of the curve's asymptotes at very small and very large amplitudes, as well as its slope over the mid-amplitude range. The proposed inverse-linear logistic model is also able to express the linear relation of duration and amplitude. We demonstrate the utility and robustness of the model when fit to aggregate data at the smalland mid-amplitude ranges, namely when fitting microsaccades, saccades, and superposition of both. We are confident the model will suitably extend to the largeamplitude range of eye movements., Competing Interests: The authors declare that there is no conflict of interest regarding the publication of this paper.

Aggressive behavior is assumed to be associated with certain patterns of social information processing. While some theories link aggression to a tendency to interpret ambiguous stimuli as hostile (i.e., enhanced sensitivity to anger), others assume an insufficient ability to perceive emotional expressions, particularly fear. Despite compelling evidence to support both theories, no previous study has directly investigated the predictions made by these two accounts in aggressive populations. The aim of the current study was to test processing patterns for angry and fearful facial expressions in violent offenders (VOs) and healthy controls (CTLs) and their association with self-reported aggression and psychopathy scores. In Experiment 1, we assessed perceptual sensitivity to neutral-emotional (angry, fearful, happy) blends in a task which did not require categorization, but an indication whether the stimulus is neutral or emotional. In Experiment 2, we assessed categorization performance for ambiguous fearful-happy and angry-happy blends. No group differences were revealed in Experiment 1, while Experiment 2 indicated a deficit in the categorization of ambiguous fearful blends in the VO group. Importantly, this deficit was associated with both self-reported psychopathy and aggression in the VO, but not the CTL group. The current study provides evidence for a deficient categorization of fearful expressions and its association with self-reported aggression and psychopathy in VOs, but no support for heightened sensitivity to anger. Furthermore, the current findings indicate that the deficit is tied to categorization but not detection stages of social information processing.

Prior studies provide evidence for impaired recognition of distress cues in individuals exhibiting antisocial behavior. However, it remains unclear whether this deficit is generally associated with antisociality or may be specific to violent behavior only. To examine whether there are meaningful differences between the two behavioral dimensions rule-breaking and aggression, violent and nonviolent incarcerated offenders as well as control participants were presented with an animated face recognition task in which a video sequence of a neutral face changed into an expression of one of the six basic emotions. The participants were instructed to press a button as soon as they were able to identify the emotional expression, allowing for an assessment of the perceived emotion onset. Both aggressive and nonaggressive offenders demonstrated a delayed perception of primarily fearful facial cues as compared to controls. These results suggest the importance of targeting impaired emotional processing in both types of antisocial behavior.

What are the determinants of altruism? While economists assume that altruism is mainly driven by fairness norms, social psychologists consider empathy to be a key motivator for altruistic behavior. To unite these two theories, we conducted an experiment in which we compared behavior in a standard economic game that assesses altruism (the so-called Dictator Game) with a Dictator Game in which participants' behavioral choices were preceded either by an empathy induction or by a control condition without empathy induction. The results of this within-subject manipulation show that the empathy induction substantially increased altruistic behavior. Moreover, the increase in experienced empathy predicted over 40% of the increase in sharing behavior. These data extend standard economic theories that altruism is based on fairness considerations, by showing that empathic feelings can be a key motivator for altruistic behavior in economic interactions.

Background: Psychogenic nonepileptic seizures (PNES) have been frequently linked to deficits in affect regulation and altered processing of emotionally salient information. However, less is known about how patients suffering from PNES actually process and interpret affective social stimuli. Thus, the present study aimed to investigate basal facial affect recognition as well as mind-reading skills in a sample of patients with PNES and matched control subjects., Methods: Patients with PNES (N=15) and healthy controls (N=15) completed self-report questionnaires that measured alexithymia and perceived stress vulnerability. Affect perception was tested using a series of computerized movies of models whose facial expressions slowly change from neutral to full-blown emotions (anger, fear, sadness, happiness, disgust, and surprise), allowing for a fine-grained assessment of facial emotion recognition impairments. Further, all participants were presented with the Movie for the Assessment of Social Cognition, a well-validated video-based test for the evaluation of subtle mind-reading deficits., Results: Data analyses revealed increased alexithymic traits and, impaired mentalizing skills in individuals with PNES, while basal facial expression recognition was not compromised., Discussion: The present findings are the first to demonstrate that patients with PNES exhibit several deficits in reasoning about their own and other people's mental states. Patients with PNES may benefit from psychotherapeutic interventions that focus on disturbed affect regulation and aim to enhance emotional awareness., (Copyright © 2015 Elsevier Inc. All rights reserved.)

Background and Objectives: Prior studies suggest that particularly negative emotional events tend to be experienced as temporally dilated. Perceptual characteristics of the threat cue (averted or directed angry face), state as well as individual anxiety levels have been shown to contribute to the temporal distortions, but the interplay between these factors is not well understood. The present study investigated the relative contributions of these factors in a first study using clinical sample with social anxiety disorder (SAD) and healthy controls (HC)., Methods: Participants performed a temporal bisection task (TBT) before and after a stress provocation phase, which served to induce state anxiety. During the TBT task, angry and neutral faces with averted vs. direct gaze were presented for the length of 600, 800, 1000, 1200, 1400, 1600 ms, and judged regarding their similarity to the standard durations., Results: A temporal overestimation effect for angry vs. neutral facial expressions was evident in both the HC and the SAD groups. An effect of experimentally induced state anxiety was evident solely in the SAD group, reflected in an overall increased temporal overestimation of angry vs. neutral expressions following the mood manipulation., Limitations: The clinical sample may represent a high-functioning group, as the study was conducted on college students. Replication in more heterogeneous SAD samples is needed in order to draw further conclusions., Conclusions: These results may be relevant for the understanding of the etiology and maintenance of SAD and potentially for the development of novel intervention methods., (Copyright © 2014 Elsevier Ltd. All rights reserved.)

Objective: Attention-deficit/hyperactivity disorder (ADHD) involves motivational dysfunction, characterized by excessive behavioral approach tendencies. Frontal brain asymmetry in the alpha band (8-13 Hz) in resting-state electroencephalogram (EEG) represents a neural correlate of global motivational tendencies, and abnormal asymmetry, indicating elevated approach motivation, was observed in pediatric and adult patients. To date, the relation between ADHD symptoms, depression and alpha asymmetry, its temporal metric properties and putative gender-specificity remain to be explored., Methods: Adult ADHD patients (n=52) participated in two resting-state EEG recordings, two weeks apart. Asymmetry measures were aggregated across recordings to increase trait specificity. Putative region-specific associations between asymmetry, ADHD symptoms and depression, its gender-specificity and test-retest reliability were examined., Results: ADHD symptoms were associated with approach-related asymmetry (stronger relative right-frontal alpha power). Approach-related asymmetry was pronounced in females, and also associated with depression. The latter association was mediated by ADHD symptoms. Test-retest reliability was sufficient., Conclusions: The association between reliably assessable alpha asymmetry and ADHD symptoms supports the motivational dysfunction hypothesis. ADHD symptoms mediating an atypical association between asymmetry and depression may be attributed to depression arising secondary to ADHD. Gender-specific findings require replication., Significance: Frontal alpha asymmetry may represent a new reliable marker of ADHD symptoms., (Copyright © 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.)

Socially anxious individuals have been shown to exhibit altered processing of facial affect, especially expressions signaling threat. Enhanced unaware processing has been suggested an important mechanism which may give rise to anxious conscious cognition and behavior. This study investigated whether individuals with social anxiety disorder (SAD) are perceptually more vulnerable to the biasing effects of subliminal threat cues compared to healthy controls. In a perceptual judgment task, 23 SAD and 23 matched control participants were asked to rate the affective valence of parametrically manipulated affective expressions ranging from neutral to angry. Each trial was preceded by subliminal presentation of an angry/neutral cue. The SAD group tended to rate target faces as "angry" when the preceding subliminal stimulus was angry vs. neutral, while healthy participants were not biased by the subliminal stimulus presentation. The perceptual bias in SAD was also associated with higher reaction time latencies in the subliminal angry cue condition. The results provide further support for enhanced unconscious threat processing in SAD individuals. The implications for etiology, maintenance, and treatment of SAD are discussed.

Facial affect is one of the most important information sources during the course of social interactions, but it is susceptible to distortion due to the complex and dynamic nature. Socially anxious individuals have been shown to exhibit alterations in the processing of social information, such as an attentional and interpretative bias toward threatening information. This may be one of the key factors contributing to the development and maintenance of anxious psychopathology. The aim of the current study was to investigate whether a threat-related interpretation bias is evident for ambiguous facial stimuli in a population of individuals with a generalized Social Anxiety Disorder (gSAD) as compared to healthy controls. Participants judged ambiguous happy/fearful, angry/fearful and angry/happy blends varying in intensity and rated the predominant affective expression. The results obtained in this study do not indicate that gSAD is associated with a biased interpretation of ambiguous facial affect., (Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.)

Background: Chronic depression and posttraumatic stress have been frequently observed in populations of accident victims with spinal cord injuries. Studies suggest that various risk factors contribute to the development and maintenance of these symptoms., Purpose: This study assessed psychopathology around 4 years post-discharge in a German sample of 102 participants with spinal cord injuries., Methods: A wide range of sociodemographic, clinical, and psychological variables was investigated with regard to their association with psychopathology., Results: Approximately half of the patients (46.1 %) retrospectively reported clinically relevant depressive symptoms immediately post-discharge and 12.7 % exhibited scores indicative of a present depressive disorder. In addition, 8.8 % retrospectively reported clinically relevant symptoms of posttraumatic stress disorder (PTSD) after discharge from the hospital and 2 % were currently identified with chronic PTSD symptomatology. Time since injury and negative trauma-related appraisals of the self were strongly related to current psychopathology., Conclusion: Depressive reactions and posttraumatic distress may commonly occur after spinal injuries but will usually improve over time. It might be useful to routinely arrange follow-up contacts post-discharge in order to timely identify patients who are at risk of developing chronic psychopathology and require intervention.

Aggressive individuals exhibit a strong tendency to attribute hostile intent to the behavior of others, which may lead to provocation and aggravation of socially inappropriate reactions. Limited research has investigated the hostile attribution bias in the perception of facial affect. This study examined a hostile response bias to emotionally ambiguous faces in a population of 55 incarcerated antisocial violent offenders as compared to matched control subjects. Results suggest that aggression is associated with a strong preference to interpret ambiguous stimuli containing proportions of an angry expression as hostile, while there was no evidence for a generally biased interpretation of distress cues under conditions of uncertainty. Thus, the tendency to misinterpret nonverbal cues in social interactions may at least partly underlie aggressive-impulsive behavior in susceptible individuals.

There is a wealth of evidence demonstrating an attentional bias to threat-related information in posttraumatic stress disorder (PTSD) and other anxiety disorders. However, there is an ongoing debate whether an enhanced identification of threatening information or rather difficulties to disengage from such signals of danger constitute this bias. The present study used a dual target rapid visual presentation paradigm to examine the temporal allocation of attention to facial expressions of anger and happiness in 16 Palestinian victims of torture with PTSD and 16 control subjects. Findings revealed that signals of threat seem to interfere with already processed information in individuals suffering from PTSD. In contrast, PTSD does not facilitate attention to threatening information. The data provide support for detrimental disengagement as an underlying mechanism of the attentional bias toward threat in PTSD, possibly contributing to symptom development and maintenance., (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.)