181 results on '"Salari R"'
Search Results
2. Circulating tumor DNA in neoadjuvant-treated breast cancer reflects response and survival
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Magbanua, M.J.M., Swigart, L.B., Wu, H.-T., Hirst, G.L., Yau, C., Wolf, D.M., Tin, A., Salari, R., Shchegrova, S., Pawar, H., Delson, A.L., DeMichele, A., Liu, M.C., Chien, A.J., Tripathy, D., Asare, S., Lin, C.-H.J., Billings, P., Aleshin, A., Sethi, H., Louie, M., Zimmermann, B., Esserman, L.J., and van ‘t Veer, L.J.
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- 2021
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3. Detection of ubiquitous and heterogeneous mutations in cell-free DNA from patients with early-stage non-small-cell lung cancer
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Jamal-Hanjani, M., Wilson, G.A., Horswell, S., Mitter, R., Sakarya, O., Constantin, T., Salari, R., Kirkizlar, E., Sigurjonsson, S., Pelham, R., Kareht, S., Zimmermann, B., and Swanton, C.
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- 2016
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4. Evaluating the safety and efficacy of wormwood vaginal cream on sexual satisfaction and quality of sexual life of postmenopausal women: a randomized, triple-blinds, placebo-controlled clinical trial
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Hajatpoor Niloufar, Babazadeh Raheleh, Salari Roshanak, Jamali Jamshid, and Izanlou Sharbanoo
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Wormwood ,Sexual satisfaction ,Quality of sexual life ,Postmenopausal ,Gynecology and obstetrics ,RG1-991 ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background The physical and mental changes created during menopause cause sexual dysfunction, which affects the quality of life, self-esteem, and emotional relationships. Wormwood cream contains tannins, terpenoids, flavonoids, phytosterols, and alkaloids. The purpose of this study is to evaluate the safety and effectiveness of wormwood vaginal cream on the sexual satisfaction and quality of sexual life of postmenopausal women. Method This study was a randomized, triple-blind, placebo-controlled clinical trial conducted on 112 postmenopausal women (45–65 years old) in 2021. The studied women were randomly assigned to two wormwood cream or placebo groups. Wormwood cream or placebo was used for 4 weeks and 3 times a week. The main data collection tools included the Larson Sexual Satisfaction Questionnaire (LSSQ) and the Sexual Quality of Life Questionnaire (SQOL-F). SPSS software version 26 and independent t, Mann–Whitney, paired t and Wilcoxon tests were used for statistical analysis. P
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- 2024
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5. Validity of Strengths and Difficulties Questionnaire in non-clinical samples of parents and teachers: Anton Dahlberg
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Dahlberg, A, Ghaderi, A, Sarkadi, A, and Salari, R
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- 2017
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6. Pilot study of a group intervention for unaccompanied refugee minors with symptoms of PTSD in Sweden: Anna Sarkadi
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Salari, R, Ssegonja, R, and Sarkadi, A
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- 2017
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7. Inter-rater agreement between parent and teacher SDQ ratings in Swedish 3–5-year-olds: Elisabet Fält
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Fält, E, Wallby, T, Sarkadi, A, Salari, R, and Fabian, H
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- 2017
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8. Detection of 793/B serotype of infectious bronchitis virus in tissue sample by indirect immunoperoxidase assay
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Shamsaddini-Bafti, Mehrdad, Vasfi-Marandi, M., Momayez, R., Toroghi, R., Pourbakhsh, S. A., Salari, R., and Tabrizchi, H.
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- 2014
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9. Comparison of different inoculation methods of H9N2 subtype avian influenza virus in broiler chickens
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Shamsaddini Bafti, Mehrdad, Momayez, R., Pourbakhsh, S. A., and Salari, R.
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- 2012
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10. O-8 Somatic and germline heterogeneity across colorectal cancer patient characteristics: Implications for early cancer detection
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Weitzel, J., Srinivasan, P., Gutman, B., Bristow, S., Wu, H., Salari, R., Swenerton, R., Kawli, T., Aleshin, A., Rabinowitz, M., Zimmermann, B., Mitchell, B., and Reiter, J.
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- 2023
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11. Analysis of F9 point mutations and their correlation to severity of haemophilia B disease
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Hamasaki-Katagiri, N., Salari, R., Simhadri, V. L., Tseng, S. C., Needlman, E., Edwards, N. C., Sauna, Z. E., Grigoryan, V., Komar, A. A., Przytycka, T. M., and Kimchi-Sarfaty, C.
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- 2012
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12. W–Ti–O layers for gas-sensing applications: Structure, morphology, and electrical properties
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Sangaletti, L., Bontempi, E., Depero, L. E., Salari, R., Zocchi, M., Nelli, P., Sberveglieri, G., Galinetto, P., Ferroni, M., Guidi, V., and Martinelli, G.
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- 1998
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13. 1762P Association of clonal hematopoiesis of indeterminate potential with higher risk of disease progression
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Klarin, D., Kalashnikova, E., Wu, H-T., Mehta, S., Salari, R., Sethi, H., Zimmermann, B., Billings, P.R., and Aleshin, A.
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- 2021
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14. Characterization of Encapsulated Berberine in Yeast Cells of Saccharomyces cerevisiae
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Salari, R., Rajabi, O., zahra khashyarmanesh, Najafi, M. F., and Fazly Bazzaz, B. S.
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yeast cells ,Berberine ,kinetic ,microencapsulation ,Original Article ,MIC - Abstract
Berberine was loaded in yeast cells of Saccharomyces cerevisiaeas a novel pharmaceutical carrier to improve the treatment ofmany diseases. The yeast-encapsulated active materialsshowedhigh stability and bioavailability due to the enhanced solubility and sustained releasing. In this study, different characteristics of prepared berberine loaded yeast cells (loading capacity, release kinetic order, MIC and stability) were evaluatedby different analytical methods (fluorescence spectroscopy, HPLC and SEM).The loading capacity was about 78% ± 0.6%.Berberine release patterns of microcapsules happened in two different stages and followed by zero and first-order kinetic,respectively. About 99% of all active material released during 34 h. MIC was improved by berberine loaded microcapsules in comparison withberberine powder. The microcapsules were completely stable. Berberine loaded Sac. Cerevisiae could be considered as a favorite sustained release drug delivery system. The yeast would be applied as an efficient carrier to improve various properties of different active materials.
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- 2015
15. Phylogenetic ctDNA analysis depicts early stage lung cancer evolution
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Abbosh, C, Birkbak, NJ, Wilson, GA, Jamal-Hanjani, M, Constantin, T, Salari, R, Quesne, JL, Moore, DA, Veeriah, S, Rosenthal, R, Marafioti, T, Kirkizlar, E, Watkins, TBK, McGranahan, N, Ward, S, Martinson, L, Riley, J, Fraioli, F, Bakir, MA, GrÖnroos, E, Zambrana, F, Endozo, R, Bi, WL, Fennessy, FM, Sponer, N, Johnson, D, Laycock, J, Shafi, S, Czyzewska-Khan, J, Rowan, A, Chambers, T, Matthews, N, Turajlic, S, Hiley, C, Lee, SM, Forster, MD, Ahmad, T, Falzon, M, Borg, E, Lawrence, D, Hayward, M, Kolvekar, S, Panagiotopoulos, N, Janes, SM, Thakrar, R, Ahmed, A, Blackhall, F, Summers, Y, Hafez, D, Naik, A, Ganguly, A, Kareht, S, Shah, R, Joseph, L, Quinn, AM, Crosbie, P, Naidu, B, Middleton, G, Langman, G, Trotter, S, Nicolson, M, Remmen, H, Kerr, K, Chetty, M, Gomersall, L, Fennell, DA, Nakas, A, Rathinam, S, Anand, G, Khan, S, Russell, P, Ezhil, V, Ismail, B, Irvin-sellers, M, Prakash, V, Lester, JF, Kornaszewska, M, Attanoos, R, Adams, H, Davies, H, Oukrif, D, Akarca, AU, Hartley, JA, Lowe, HL, Lock, S, Iles, N, Bell, H, Ngai, Y, Elgar, G, Szallasi, Z, Schwarz, RF, Herrero, J, Stewart, A, Quezada, SA, Van Loo, P, Dive, C, Lin, CJ, Rabinowitz, M, Aerts, HJWL, Hackshaw, A, Shaw, JA, Zimmermann, BG, Swanton, C, Bosshard-Carter, L, Goh, G, Gorman, P, Murugaesu, N, Hynds, RE, Wilson, G, Horswell, S, Al Bakir, M, Mitter, R, Escudero, M, Xu, H, Goldman, J, Stone, RK, Denner, T, Biggs, J, Costa, M, Begum, S, Phillimore, B, Nye, E, Graca, S, Joshi, K, Furness, A, Aissa, AB, Wong, YNS, Georgiou, A, Quezada, S, Simeon, C, Hector, G, Smith, A, Aranda, M, Novelli, M, Forster, M, Papadatos-Pastos, D, Carnell, D, Mendes, R, George, J, Navani, N, Taylor, M, Choudhary, J, Califano, R, Taylor, P, Krysiak, P, Rammohan, K, Fontaine, E, Booton, R, Evison, M, Moss, S, Idries, F, Bishop, P, Chaturved, A, Marie Quinn, A, Doran, H, leek, A, Harrison, P, Moore, K, Waddington, R, Novasio, J, Rogan, J, Smith, E, Tugwood, J, Brady, G, Rothwell, DG, Chemi, F, Pierce, J, Gulati, S, Bellamy, M, Bancroft, H, Kerr, A, Kadiri, S, Webb, J, Djearaman, M, Fennell, D, Le Quesne, J, Moore, D, Thomas, A, Walter, H, Monteiro, W, Marshall, H, Nelson, L, Bennett, J, Primrose, L, Amadi, A, Palmer, S, Miller, J, Buchan, K, Lester, J, Edwards, A, Morgan, F, Verjee, A, MacKenzie, M, Wilcox, M, Smith, S, Gower, N, Ottensmeier, C, Chee, S, Johnson, B, Alzetani, A, Shaw, E, Lim, E, De Sousa, P, Tavares Barbosa, M, Bowman, A, Jordan, S, Rice, A, Raubenheimer, H, Proli, C, Elena Cufari, M, Ronquillo, JC, Kwayie, A, Bhayani, H, Hamilton, M, Bakar, Y, Mensah, N, Ambrose, L, Devaraj, A, Buderi, S, Finch, J, Azcarate, L, Chavan, H, Green, S, Mashinga, H, Nicholson, AG, Lau, K, Sheaff, M, Schmid, P, Conibear, J, Light, T, Horey, T, Danson, S, Bury, J, Edwards, J, Hill, J, Matthews, S, Kitsanta, Y, Suvarna, K, Fisher, P, Keerio, AD, Shackcloth, M, Gosney, J, Postmus, P, Feeney, S, Asante-Siaw, J, Constatin, T, Zimmermann, B, Dentro, S, Dessimoz, C, Shiu, K-K, Bridgewater, J, Hochauser, D, Beck, S, Parker, P, Walczak, H, Enver, T, Proctor, I, Sinclair, R, Lok, C-W, Mitchison, M, Trevisan, G, Lynch, M, Brandner, S, Gishen, F, Tookman, A, Stone, P, Sterling, C, Larkin, J, Attard, G, Eeles, R, Foster, C, Bova, S, Sottoriva, A, Chowdhury, S, Ashish, C, Spicer, J, Stares, M, Lynch, J, Caldas, C, Brenton, J, Fitzgerald, R, Jimenez-Linan, M, Provenzano, E, Cluroe, A, Stewart, G, Watts, C, Gilbertson, R, McDermott, U, Tavare, S, Maughan, T, Tomlinson, I, Campbell, P, McNeish, I, Biankin, A, Chambers, A, Fraser, S, Oien, K, Krebs, M, Marais, R, Carter, L, Nonaka, D, Dhomen, N, Shaw, J, Baijal, S, Tanchel, B, Collard, M, Cockcroft, P, Taylor, J, Colloby, P, Olisemeke, B, Wilson, R, Harrison, D, Loda, M, Flanagan, A, McKenzie, M, Lederman, J, Sharp, A, and Farrelly, L
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0301 basic medicine ,Oncology ,Lung Neoplasms ,IMPACT ,Biopsy ,DNA Mutational Analysis ,Drug resistance ,Metastasis ,0302 clinical medicine ,Limit of Detection ,Carcinoma, Non-Small-Cell Lung ,Medicine ,Neoplasm Metastasis ,Early Detection of Cancer ,Multidisciplinary ,medicine.diagnostic_test ,Phylogenetic tree ,DNA, Neoplasm ,STATISTICS ,3. Good health ,Tumor Burden ,Multidisciplinary Sciences ,Cell Tracking ,PEACE consortium ,030220 oncology & carcinogenesis ,Disease Progression ,Science & Technology - Other Topics ,medicine.medical_specialty ,CARCINOMA ,Tumour heterogeneity ,General Science & Technology ,Early detection ,Evolution, Molecular ,03 medical and health sciences ,Internal medicine ,MD Multidisciplinary ,Carcinoma ,Humans ,Cell Lineage ,Lung cancer ,Postoperative Care ,Science & Technology ,MUTATIONS ,TRACERx consortium ,business.industry ,CIRCULATING TUMOR DNA ,Reproducibility of Results ,medicine.disease ,R1 ,NEGATIVE BREAST-CANCER ,Clone Cells ,030104 developmental biology ,Drug Resistance, Neoplasm ,UPTAKE RATIO ,Immunology ,FDG PET ,Neoplasm Recurrence, Local ,business ,Multiplex Polymerase Chain Reaction - Abstract
The early detection of relapse following primary surgery for non-small-cell lung cancer and the characterization of emerging subclones, which seed metastatic sites, might offer new therapeutic approaches for limiting tumour recurrence. The ability to track the evolutionary dynamics of early-stage lung cancer non-invasively in circulating tumour DNA (ctDNA) has not yet been demonstrated. Here we use a tumour-specific phylogenetic approach to profile the ctDNA of the first 100 TRACERx (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy (Rx)) study participants, including one patient who was also recruited to the PEACE (Posthumous Evaluation of Advanced Cancer Environment) post-mortem study. We identify independent predictors of ctDNA release and analyse the tumour-volume detection limit. Through blinded profiling of postoperative plasma, we observe evidence of adjuvant chemotherapy resistance and identify patients who are very likely to experience recurrence of their lung cancer. Finally, we show that phylogenetic ctDNA profiling tracks the subclonal nature of lung cancer relapse and metastasis, providing a new approach for ctDNA-driven therapeutic studies.
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- 2017
16. Lidocaine Cyclodextrin complex Ophthalmic Drop, a New Topical Anesthetic Choice
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Sabermoghadam Ranjbar, AA, Rajabi, O, Salari, R, and Ashraf, H
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Symblepharon ,Ophthalmicdrop ,Lidocaine ,Cyclodextrin ,Original Article ,Dysport ,Drug Delivery ,Pterygium - Abstract
Background Topical anesthesia is a safe and cost-effective method considered as the first-choice in many procedures. Due to the physiological characteristics of eye, most of the local anesthetics cannot efficiently penetrate through the conjunctiva deep to tenon. The aim of this pilot study was to find a new form of lidocaine to give a sufficient level of anesthesia. Methods: Lidocaine Cyclodextrin complex ophthalmic drop was produced and its pharmacological properties were studied [tested] in standard temperature and pressure. 30 patients (18 males, 12 females) with the mean age of 30.68±8.02 years enrolled in this clinical trial. All the patients were fully informed and signed the ethics committee consent forms. The patients were given tetracaine drop as the anesthetic: 3 drops separated 2 minute apart 10 min before the intervention. If we achieved a sufficient level of anesthesia, the procedure was done after. If the patient could not tolerate the procedure, the method was changed to lidocaine drop (administered after wash-out period like the first drop).The last option was conventional injection method if the patient could not tolerate the procedure with the second method either.We used this type of anesthesia for conventional procedures such as forced duction test, symblepharon, pterygium, and disport injection into extra-ocular muscles. All the procedures were done by one surgeon in a university hospital. We used a 0 to 10 visual analogue scale for pain and two 0 to 4 patient and physician satisfaction scales designed for this study. Results The mean pain score was 7.53±0.90 in group 1 and 3.03±1.83 in group 2 (P=0.00). Patient and surgeon satisfaction in group 1 were 1.33±0.48 and 1.40±0.56 respectively; while 3.23±1.00 and 3.56±0.77 for group 2 (P=0.00). Tetracaine drop could not induce sufficient anesthesia for none of the patients. Cyclodextrin based lidocaine drop was successful except For two patients for whom we changed the anesthesia to Sub-conjunctival injection method. Conclusion Our newly manufactured cyclodextrin based lidocaine eye drop could successfully induce sufficient anesthesia for 28 of 30 patients. Further studies with larger sample sizes are now being designed to find more clinical evidence about this method.
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- 2012
17. 166P - Analysis of circulating tumour DNA for early relapse detection in stage III colorectal cancer after adjuvant chemotherapy
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Jacobs, S.A., Sethi, H., Kolveska, T., George, T.J., Shchegrova, S., Tin, T., Lee, J., Olson, A., Renner, D., Kalashnikova, E., Yothers, G., Wolmark, N., Pogue-Geile, K.L., Srinivasan, A., Kortmansky, J., Louie, M., Salari, R., Zimmermann, B., Aleshin, A., and Allegra, C.J.
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- 2019
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18. 110P - Presence of circulating tumour DNA in surgically resected renal cell carcinoma is associated with advanced disease and poor patient prognosis
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Correa, A., Connolly, D.C., Balcioglu, M., Wu, H.-T., Dashner, S., Shchegrova, S., Kalashnikova, E., Pawar, H., Uzzo, R.G., Gong, Y., Kister, D., Collins, M., Donovan, M., Winters, R., Aleshin, A., Sethi, H., Salari, R., Louie, M., Zimmermann, B., and Abbosh, P.
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- 2019
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19. 456PD - Serial circulating tumor DNA analysis for detection of residual disease, assessment of adjuvant therapy efficacy and for early recurrence detection in colorectal cancer
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Reinert, T., Henriksen, T.V., Rasmussen, M.H., Sethi, H., Salari, R., Shchegrova, S., Swenerton, R., Wu, H.-T., Sharma, S., Christensen, E., Natarajan, P., Dashner, S., Tin, T., Olson, A., Pawar, H., Zimmermann, B., Iversen, L.H., Madsen, M.R., Lin, J., and Andersen, C.L.
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- 2018
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20. 86P - Longitudinal assessment of multiplex patient-specific ctDNA biomarkers in bladder cancer for diagnosis, surveillance and recurrence
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Birkenkamp-Demtröder, K., Christensen, E., Sethi, H., Sharma, S., Wu, H.-T., Taber, A., Agerbæk, M., Swenerton, R., Salari, R., Hafez, D., Nordentoft, I., Lamy, P., Srinivasan, R., Balcioglu, M., Navarro, S., Assaf, Z., Zimmermann, B., Lin, J., Bjerggaard Jensen, J., and Dyrskjøt, L.
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- 2018
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21. Assessment of the Microbiological Quality and Mycotoxin Contamination of Iranian Red Pepper Spice.
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Salari, R., Habibi Najafi, M. B., Boroushaki, M. T., Mortazavi, S. A., and Fathi Najafi, M.
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PEPPERS , *SPICES , *PRODUCT quality , *OCHRATOXINS , *MICROBIAL contamination , *MICROBIOLOGY , *PLANTS - Abstract
The objective of this study was to assess the microbial contamination of Razavi Khorasan (Iran) hot red pepper. The natural occurrence of aflatoxins and ochratoxin A in those samples was also investigated. For this purpose, 36 samples of this kind of pepper were collected from a farm and sun-dried. Standard and established methods were used for both microbiological analyses and mycotoxins identification. Total aerobic mesophilic counts of samples varied from 102 to 4×106 cfu g-1. Coliforms were present at high levels in all samples ranging from 1.9×102 to 3.52×106 cfu g-1that may indicate inappropriate hygienic quality of samples. 42% of the samples were of unsatisfactory quality due to the presence of E. coli. In all samples examined, sulphite-reducing clostridia (SRC) was below detection limit and Salmonella spp. was not detected. Fungi were found in all of the collected samples. Mold and yeast were generally high ranging from 2.4×103 to 4.6×106 cfu g-1and the most predominant fungal genera were Aspergillus spp., Penicillium spp and Rhizopus spp. Considering the results obtained, the samples analyzed contain a high level of microorganisms and only two samples (6%) had acceptable levels for all microbial factors according to EU Commission Recommendation (directive2004/24/EC). 69% and 17% of samples were found contaminated with total aflatoxins and ochratoxin A, respectively, that might contribute to health hazards for humans. Overall, The Razavi Khorasan hot red pepper samples collected for this study were contaminated with microorganisms and mycotoxins, which suggests that hygiene practice pre- and postharvesting must be improved if the region is to exploit fully the potential for this valuable product. [ABSTRACT FROM AUTHOR]
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- 2012
22. Sparsification of RNA structure prediction including pseudoknots
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Backofen Rolf, Will Sebastian, Salari Raheleh, Möhl Mathias, and Sahinalp S Cenk
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Biology (General) ,QH301-705.5 ,Genetics ,QH426-470 - Abstract
Abstract Background Although many RNA molecules contain pseudoknots, computational prediction of pseudoknotted RNA structure is still in its infancy due to high running time and space consumption implied by the dynamic programming formulations of the problem. Results In this paper, we introduce sparsification to significantly speedup the dynamic programming approaches for pseudoknotted RNA structure prediction, which also lower the space requirements. Although sparsification has been applied to a number of RNA-related structure prediction problems in the past few years, we provide the first application of sparsification to pseudoknotted RNA structure prediction specifically and to handling gapped fragments more generally - which has a much more complex recursive structure than other problems to which sparsification has been applied. We analyse how to sparsify four pseudoknot structure prediction algorithms, among those the most general method available (the Rivas-Eddy algorithm) and the fastest one (Reeder-Giegerich algorithm). In all algorithms the number of "candidate" substructures to be considered is reduced. Conclusions Our experimental results on the sparsified Reeder-Giegerich algorithm suggest a linear speedup over the unsparsified implementation.
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- 2010
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23. Fast prediction of RNA-RNA interaction
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Backofen Rolf, Salari Raheleh, and Sahinalp S Cenk
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Biology (General) ,QH301-705.5 ,Genetics ,QH426-470 - Abstract
Abstract Background Regulatory antisense RNAs are a class of ncRNAs that regulate gene expression by prohibiting the translation of an mRNA by establishing stable interactions with a target sequence. There is great demand for efficient computational methods to predict the specific interaction between an ncRNA and its target mRNA(s). There are a number of algorithms in the literature which can predict a variety of such interactions - unfortunately at a very high computational cost. Although some existing target prediction approaches are much faster, they are specialized for interactions with a single binding site. Methods In this paper we present a novel algorithm to accurately predict the minimum free energy structure of RNA-RNA interaction under the most general type of interactions studied in the literature. Moreover, we introduce a fast heuristic method to predict the specific (multiple) binding sites of two interacting RNAs. Results We verify the performance of our algorithms for joint structure and binding site prediction on a set of known interacting RNA pairs. Experimental results show our algorithms are highly accurate and outperform all competitive approaches.
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- 2010
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24. Evidence of Translational Disorder Generated by Oriented Defects in Magneli Phases
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Sangaletti, L., Depero, L.E., Bontempi, E., Salari, R., and Sberveglieri, G.
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- 1997
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25. Baker's cyst simulating deep vein thrombosis
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Chaudhuri, R. and Salari, R.
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- 1990
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26. Whole-genome progression of breast cancer from early neoplasia to invasive carcinoma.
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West, R. B., Kashef-Haghighi, D., Newburger, D., Weng, Z., Brunner, A., Salari, R., Guo, X., Troxell, M., Zhu, S., Varma, S., Sidow, A., and Batzoglou, S.
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CELL proliferation , *CANCER research , *GENOMES , *CANCER patients , *EPIGENETICS - Abstract
Cancer evolution involves cycles of genomic damage, epigenetic deregulation, and increased cellular proliferation that eventually culminate in the carcinoma phenotype. Early breast neoplasias include usual ductal hyperplasia, columnar cell lesions, and flat epithelial atypia and some are thought to represent precursor stages. To elucidate their role in cancer evolution we performed comparative whole genome sequencing of early neoplasias, matched normal tissue, and carcinomas from six patients. The identified somatic mutations served as lineage markers to build trees that relate the tissue samples. On the basis of the lineage trees we inferred the order, timing, and rates of mutational events. We find that in a subset of cases, the last common ancestor of an early neoplasm and a carcinoma was hypermutated and had several aneuploidies, and that evolution further accelerated in the carcinoma lineage. In contrast to highly advanced tumors that are the focus of much of current cancer genome sequencing, the early neoplasia genomes, and the carcinomas as well, harbor a striking paucity of potentially functional somatic point mutations. The earliest significant events we could detect, those changes that occurred in common ancestors of neoplastic and tumor cells, are aneuploidies. Several aneuploidies are recurrent, suggesting that they are among the earliest genomic events that predispose breast tissue to eventual development of invasive carcinoma. [ABSTRACT FROM AUTHOR]
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- 2012
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27. Using normalisation process theory to identify factors facilitating the scaling up of parenting programs for immigrant parents.
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Osman F, Schön UK, and Salari R
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Objective: As most studies focus on the initial adaptation of culturally tailored parenting programs in real-world settings, scalability and sustainability remain understudied. In this study, we used normalization process theory (NPT) as a conceptual framework to identify and understand the contextual factors impacting the scalability and sustainability of a culturally tailored parenting program, Ladnaan, in three Swedish municipalities., Method: Nineteen managers, coordinators, and group leaders completed a survey and participated in individual or focus group interviews., Results: Our analyses showed that participants agreed on the need for the Ladnaan intervention among immigrant families. However, they were concerned that insufficient resources may hinder the recruitment and retention of parents, particularly as certain resources were allocated to the delivery of other, non-evidence-based interventions. Both managers and coordinators emphasized that embedding Ladnaan into everyday practice is conditioned on the collective work and engagement of all stakeholders, which will occur only if local authorities feel they own the program. The recruitment and retention of group leaders was mentioned as a key challenge in sustaining Ladnaan as the need for the program fluctuated over time., Conclusion: These findings highlight the importance of promoting evidence-based programs within the services available for forcibly displaced parents, and of coordinating efforts to scale up and sustain these programs., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Osman, Schön and Salari.)
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- 2024
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28. Quality of couple relationship and associated factors in parents of NICU-cared infants during the first year after birth.
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Persson C, Ericson J, Eriksson M, Salari R, and Flacking R
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- Humans, Female, Male, Infant, Newborn, Longitudinal Studies, Adult, Depression, Parents psychology, Interpersonal Relations, Infant, Length of Stay statistics & numerical data, Surveys and Questionnaires, Intensive Care Units, Neonatal, Social Support
- Abstract
Objective: To describe factors associated with quality of couple relationships among parents of infants cared for in neonatal intensive care units (NICUs) 1 year after birth and examine the trajectory of the relationship quality compared to parents from maternity units (MUs)., Study Design: Longitudinally comparative cohort design. Parents answered surveys during the first year after discharge about the couple relationship, social support, and depressive symptoms., Results: Better social support and a hospital stay of 7-14 days were positively associated with the couple relationship in NICU mothers, whereas not having slept together with the partner and infant during hospitalization were negatively associated. Depressive symptoms were negatively associated with the relationship among NICU fathers. There were no differences in trajectory of the relationship quality between NICU and MU parents., Conclusion: To strengthen couple relationships, it could be important to improve social support, facilitate space and time for support, and enable togetherness during hospitalization., Competing Interests: Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: Informed consent was obtained from all participants. Ethical approval was obtained from the Swedish Ethical Review Authority, dnr: 2019-04367. The study was performed in accordance with the Declaration of Helsinki., (© 2024. The Author(s).)
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- 2024
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29. Preschool-level socio-economic deprivation in relation to emotional and behavioural problems among preschool children in Sweden.
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Durbeej N, Ssegonja R, Salari R, Dahlberg A, Fabian H, and Sarkadi A
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- Humans, Sweden epidemiology, Male, Female, Child, Preschool, Cross-Sectional Studies, Affective Symptoms epidemiology, Surveys and Questionnaires, Problem Behavior psychology, Socioeconomic Factors, Child Behavior Disorders epidemiology
- Abstract
Aims: The aim of this study was to explore the association between preschool-level socio-economic deprivation and emotional and behavioural problems among preschool children in Sweden using a multilevel approach., Methods: In this cross-sectional study, we used data on 2267 children whose parents and preschool teachers had responded to items measuring individual-level socio-economic deprivation and the Strengths and Difficulties Questionnaire (SDQ) for assessment of emotional and behavioural problems. Further, the Socioeconomic Structure Compensation Index (SSCI), collected from Uppsala municipality, was used to assess preschool-level socio-economic deprivation. Unadjusted and adjusted multilevel logistic regression models were used to explore the relations between preschool-level socio-economic deprivation and emotional and behavioural problems., Results: In unadjusted models, children who attended preschools classified as highly deprived had elevated odds for emotional symptoms (odds ratio (OR) 1.71) as rated by parents. However, this association did not remain significant after adjusting for individual-level socio-economic deprivation factors. In both unadjusted and adjusted models, children who attended preschools classified as moderately deprived had elevated odds for peer-relationship problems as rated by parents (OR 1.63; adjusted OR 1.48). There were no significant associations between preschool deprivation and emotional and behavioural problems as rated by preschool teachers., Conclusions: Swedish preschools may have a compensatory capacity in addressing children's emotional and behavioural problems, whereas preschool-level deprivation remained significantly associated with peer-relationship problems after controlling for individual-level socio-economic deprivation factors. This implies that peer-relationship problems in deprived preschools need to be addressed in a broader community context., Competing Interests: Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship and/or publication of this article.
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- 2024
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30. Not attending preschool was linked to challenges in peer relationships.
- Author
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Fabian H, Fält E, Dahlberg A, Salari R, and Durbeej N
- Subjects
- Humans, Child, Preschool, Female, Male, Cross-Sectional Studies, Sweden, Interpersonal Relations, Peer Group
- Abstract
Aim: There is limited research on the impact of preschool attendance on socio-emotional problems. This study aimed to investigate the association between not attending preschool and emotional and behavioural problems among children aged 3-5 years in Sweden., Methods: We analysed cross-sectional data from 9395 children, rated by both parents or by one parent. The dependent variable, emotional and behavioural problems, was measured using the Strengths and Difficulties Questionnaire (SDQ). Preschool attendance served as the independent variable. Single and multiple logistic regression analyses were conducted., Results: Only 1.2% of children did not attend preschool. Single logistic regression models, using SDQ subscales with scores at or above the cut-off point as outcomes, showed that not attending preschool was associated with peer relationship problems, rated by mothers, and with peer relationship problems and overall difficulties, rated by fathers. These associations remained significant when controlling for covariates. Children with parents born outside Sweden or with lower educational levels had higher odds of experiencing peer relationship problems and overall difficulties., Conclusion: Children who do not attend preschool are at heightened risk of experiencing peer relationship problems. It is important to ensure that children who may benefit most from preschool education receive adequate support., (© 2024 The Author(s). Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.)
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- 2024
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31. Correlation between variant allele frequency and mean tumor molecules with tumor burden in patients with solid tumors.
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Kalashnikova E, Aushev VN, Malashevich AK, Tin A, Krinshpun S, Salari R, Scalise CB, Ram R, Malhotra M, Ravi H, Sethi H, Sanchez S, Hagelstrom RT, Brevnov M, Rabinowitz M, Moshkevich S, Zimmermann BG, Liu MC, and Aleshin A
- Subjects
- Humans, Male, Female, Middle Aged, Aged, Biomarkers, Tumor genetics, Biomarkers, Tumor blood, Prognosis, Cohort Studies, Circulating Tumor DNA genetics, Circulating Tumor DNA blood, Neoplasms genetics, Neoplasms pathology, Neoplasms blood, Gene Frequency, Tumor Burden
- Abstract
Several studies have demonstrated the prognostic value of circulating tumor DNA (ctDNA); however, the correlation of mean tumor molecules (MTM)/ml of plasma and mean variant allele frequency (mVAF; %) with clinical parameters is yet to be understood. In this study, we analyzed ctDNA data in a pan-cancer cohort of 23 543 patients who had ctDNA testing performed using a personalized, tumor-informed assay (Signatera™, mPCR-NGS assay). For ctDNA-positive patients, the correlation between MTM/ml and mVAF was examined. Two subanalyses were performed: (a) to establish the association of ctDNA with tumor volume and (b) to assess the correlation between ctDNA dynamics and patient outcomes. On a global cohort, a positive correlation between MTM/ml and mVAF was observed. Among 18 426 patients with longitudinal ctDNA measurements, 13.3% had discordant trajectories between MTM/ml and mVAF at subsequent time points. In metastatic patients receiving immunotherapy (N = 51), changes in ctDNA levels expressed both in MTM/ml and mVAF showed a statistically significant association with progression-free survival; however, the correlation with MTM/ml was numerically stronger., (© 2023 Natera, Inc. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.)
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- 2024
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32. Development and Usability Evaluation of COVID-Iran: A Mobile Application for Mitigating COVID-19 Misinformation.
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Salari R, Fatehi F, and Mehdizadeh H
- Abstract
Objectives: The spread of misinformation through the internet can lead to dangerous behavioral changes and erode trust in reliable sources, especially during public health crises like coronavirus disease 2019 (COVID-19). To combat this issue, innovative strategies that leverage information technology are essential. This study focused on developing and evaluating a mobile application (app), COVID-Iran, aimed at countering COVID-19 misinformation by delivering accurate, reliable, and credible information., Methods: The development of the app involved a multi-step, user-centered approach that integrated qualitative expert consultations with quantitative survey research to pinpoint and validate key features. The app was initially prototyped using Enterprise Architect software and subsequently developed using Android Studio and MySQL. We conducted a usability evaluation using the System Usability Scale (SUS), where participants engaged in various tasks related to information seeking, self-assessment, and health management. Data were analyzed using descriptive statistics in SPSS version 19., Results: The findings revealed a high usability level (SUS score of 81.35), with participants reporting ease of use and learnability. The app effectively countered misinformation by providing access to trusted sources and evidence-based counterarguments. User feedback emphasized the app's strengths in clarity, accuracy, trustworthiness, and its comprehensive approach. Plans for future improvements include the integration of artificial intelligence to deliver personalized content., Conclusions: Despite limitations such as the small sample size and potential self-selection bias, this study highlights the significant potential of mHealth apps to provide reliable health information and combat misinformation.
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- 2024
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33. An efficient chemiluminescent probe based on Ni-doped CsPbBr 3 perovskite nanocrystals embedded in mesoporous SiO 2 for sensitive assay of L-cysteine.
- Author
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Salari R and Amjadi M
- Abstract
This study presents an efficient chemiluminescence (CL) probe based on perovskite nanocrystals (NCs) for detection of L-cysteine (L-Cys). It consists of nickel-doped CsPbBr
3 NCs embedded in the mesoporous SiO2 matrix as CL reagent and cerium (IV) as an oxidant in aqueous environment. The probe was designed for the highly selective determination of L-Cys based on its remarkable enhancing effect on the CL intensity. The colloidal nanocomposite of nickel-doped CsPbBr3 NCs@SiO2 with photoluminescence quantum yield of 58% was fabricated by ligand-assisted re-precipitation method and characterized by using UV-Vis absorption, FT-IR, X-ray diffraction, and transmission electron microscopy. The sensor was utilized to determine L-Cys in the linear concentration range of 20-300 nM with a detection limit of 12.8 nM. Direct chemical oxidation of Ni-doped CsPbBr3 NCs@SiO2 by Ce(IV) was the single cause of the formation of the excited-state NCs and subsequent production of CL. The developed probe provides outstanding selectivity towards L-Cys over structurally related compounds. Accurate determination of L-Cys in human serum samples was achieved without interference, and the results were confirmed by HPLC method., (© 2024. The Author(s).)- Published
- 2024
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34. La(FeCuMnMgTi)O 3 High-Entropy Oxide Nanoparticles as Highly Efficient Catalysts for Solvent-Free Aerobic Oxidation of Benzyl Alcohol.
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Ostovari Moghaddam A, Mehrabi-Kalajahi S, Qi X, Salari R, Fereidonnejad R, Abdollahzadeh A, Uchaev DA, Kazakova EA, Varfolomeev MA, Cabot A, Vasenko AS, and Trofimov EA
- Abstract
In this work, a solid-state method for the synthesis of perovskite La(FeCuMnMgTi)O
3 high-entropy oxide (HEO) nanoparticles is detailed. Additionally, the high performance of these nanoparticles as catalysts in the aerobic and solvent-free oxidation of benzyl alcohol is demonstrated. The structural features of HEO nanoparticles are studied by X-ray diffraction and high-resolution transmission electron microscopy. The La(FeCuMnMgTi)O3 nanoparticles demonstrate excellent benzyl alcohol conversion rates and selectivity for benzaldehyde, reaching 10.6% conversion and 52.8% selectivity after reaction for only 4 h and ≤75.6% conversion after 24 h. In addition, the as-prepared HEO catalyst displays robust stability in benzyl alcohol oxidation. Density functional theory calculations demonstrate that the adsorption energy of benzaldehyde on the HEO surface is lower than that of the benzoic acid. This, in turn, hinders the gradual conversion of benzaldehyde to benzoic acid on the surface of HEO and retains benzaldehyde as the main product.- Published
- 2024
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35. Evaluation of the Teaching Recovery Techniques intervention among newcomer students in Swedish schools: a randomised controlled trial turned into a feasibility study.
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Durbeej N, Salari R, Sarkadi A, Kankaanpä R, Derluyn I, Verelst A, and Osman F
- Subjects
- Humans, Sweden, Male, Female, Adolescent, Schools, Program Evaluation, Stress Disorders, Post-Traumatic, Feasibility Studies, Students psychology, Students statistics & numerical data
- Abstract
Background: During recent years, Europe has faced the arrival of migrants whereof a considerable group of youth present mental health problems, such as symptoms of post-traumatic stress disorder (PTSD). Schools offer a safe environment for mental health interventions to these groups, yet there is limited research on the impact of school-based interventions addressing mental health problems in newcomer youths, especially in the Swedish context. This cluster randomized controlled trial (RCT) aimed to explore the effectiveness of the Teaching Recovery Techniques (TRT) intervention among newcomer students with PTSD symptoms in Swedish secondary schools., Methods: Nine schools were randomly assigned to TRT or a wait list control group prior to the baseline assessment. Follow-up data were collected immediately following the intervention and three months post-intervention. In total, 531 students were approached, of which 61 gave consent and were eligible to be included in the study: 55 in TRT and 6 in the control condition. Given the low number of participants in the control condition, we merely analyzed students who had received TRT., Results: We report on feasibility of recruitment, data collection, intervention delivery and intervention effectiveness. In terms of intervention effectiveness, within subjects ANOVAs revealed significant reductions in PTSD symptoms and general mental health problems from baseline to the three months-follow-up (p < 0.001)., Conclusions: Our results indicate that TRT is a promising school-based intervention for newcomer students with PTSD symptoms. For a successful implementation of TRT in the school context, schools need to be engaged and the implementation should be managed by a local coordinator., Trial Registration: ISRCTN, ISRCTN48178969, Retrospectively registered 20/12/2019., (© 2024. The Author(s).)
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- 2024
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36. High-Entropy La(FeCuMnMgTi)O 3 Nanoparticles as Heterogeneous Catalyst for CO 2 Electroreduction Reaction.
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Ostovari Moghaddam A, Mehrabi-Kalajahi S, Abdollahzadeh A, Salari R, Qi X, Fereidonnejad R, Akaahimbe SA, Nangir M, Uchaev DA, Varfolomeev MA, Cabot A, Vasenko AS, and Trofimov EA
- Abstract
In this work, La(FeCuMnMgTi)O
3 HEO nanoparticles with a perovskite-type structure are synthesized and used in the electrocatalytic CO2 reduction reaction (CO2 RR). The catalyst demonstrates high performance as an electrocatalyst for the CO2 RR, with a Faradaic efficiency (FE) of 92.5% at a current density of 21.9 mA cm-2 under -0.75 V vs a saturated calomel electrode (SCE). Particularly, an FE above 54% is obtained for methyl isopropyl ketone (C5 H10 O, MIPK) at a partial current density of 16 mA cm-2 , overcoming all previous works. Besides, the as-prepared HEO catalyst displays robust stability in the CO2 RR. The excellent catalytic performance of La(FeCuMnMgTi)O3 is ascribed to the synergistic effect between the electronic effects associated with five cations occupying the high-entropy sublattice sites and the oxygen vacancies within the perovskite structure of the HEO. Finally, DFT calculations indicate that Cu plays a vital role in the catalytic activity of the La(FeCuMnMgTi)O3 HEO nanoparticles toward C2+ products.- Published
- 2024
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37. A smartphone-assisted fluorescent sensing platform for ochratoxin A using Mn-doped CsPbBr 3 perovskite quantum dots embedded in the mesoporous silica as a ratiometric probe.
- Author
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Salari R, Amjadi M, and Hallaj T
- Subjects
- Humans, Silicon Dioxide chemistry, Smartphone, Reproducibility of Results, Fluorescent Dyes chemistry, Limit of Detection, Quantum Dots chemistry, Ochratoxins, Oxides, Titanium, Calcium Compounds
- Abstract
Food sources are susceptible to contamination with ochratoxin A (OTA), which is a serious threat to human health. Thus, the construction of novel, simple sensing platforms for OTA monitoring is of utmost need. Manganese-doped lead halide perovskite quantum dots encapsulated with mesoporous SiO
2 (Mn-CsPbBr3 QDs@SiO2 ) were prepared here and used as a ratiometric fluorescent probe for OTA. Mn-CsPbBr3 QDs, synthesized at room temperature, exhibit dual emission with maximum wavelengths of 440 and 570 nm and, when embedded in the SiO2 layer, produce a stable and robust photoluminescence signal. By adding OTA to the probe, emission at 440 nm increases while emission at 570 nm decreases, so a ratiometric response is obtained. Experimental variables affecting the probe signal were studied and optimized and the mechanism of sensing was discussed. This ratiometric sensor demonstrated excellent selectivity and low detection limit (4.1 ng/ml) as well as a wide linear range from 5.0 to 250 ng/ml for OTA. A simple portable smartphone-based device was also constructed and applied for the fluorescence assay. With different OTA concentrations, the multicolor transition from pink to blue under a UV lamp led to simple visual and smartphone-assisted sensing of OTA by using a color analyzing application. Satisfactory recoveries in black tea, coffee, moldy fig and flour samples confirmed the reliability of the assay. The accuracy of the probe was proved by comparison of the results with high-performance liquid chromatography (HPLC)., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)- Published
- 2024
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38. Investigation the effect of a herbal composition based on blackseed on patients with primary hypothyroidism: A randomized controlled trial.
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Javidi N, Mazloum Khorasani Z, Salari R, Niroumand S, and Yousefi M
- Abstract
Objective: Hypothyroidism is characterized by insufficient production of thyroxine by the thyroid gland. Levothyroxine may not fully alleviate patients' symptoms. This study aimed to assess the impact of a herbal product on weight, body mass index (BMI), thyroid hormones, lipid profile, fasting blood sugar (FBS), depression, and quality-of-life scores in patients., Materials and Methods: 72 patients with primary hypothyroidism, aged between 20 and 65 years old, participated in the trial and they were randomly allocated into two groups. The intervention group received the herbal powder containing Trachyspermum ammi L., Nigella sativa L., and Citrus aurantifolia L. while the control group received Avicel for 8 weeks., Results: Treatment with the herbal product resulted in statistically significant reductions in anthropometric variables such as BMI (p=0.03), hip circumference (HC) (p=0.008), waist circumference (WC) (p<0.001), and waist-to-hip circumference ratio (WHR) (p=0.003) in the intervention group in comparison between intervention and control groups. However, the decrease in weight was not statistically significant (p=0.08) in the intervention group compared the control group. In comparison between two groups, the depression score exhibited a statistically significant decrease in the intervention (p=0.001) and control groups (p=0.01), while there was a statistically significant increase in the quality-of-life score only in the intervention group (p<0.001) in comparison between intervention and control groups., Conclusion: The results indicate the potential beneficial effects of the herbal product on anthropometric variables in patients. Furthermore, the intervention yielded significant improvements in depression symptoms and quality-of-life scores among the patients., Competing Interests: The authors have declared that there is no conflict of interest.
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- 2024
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39. Can extended health communication improve newly settled refugees' health literacy? A quasi-experimental study from Sweden.
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Al-Adhami M, Durbeej N, Daryani A, Wångdahl J, Larsson EC, and Salari R
- Subjects
- Humans, Sweden, Health Promotion, Health Literacy, Health Communication, Refugees psychology
- Abstract
Structural and contextual factors such as limited work and housing opportunities negatively affect the health and well-being of newly settled refugee migrants in receiving high-income countries. Health promotion initiatives aiming at strengthening health and integration have been tried out within the Swedish Introduction program for refugee migrants. However, longitudinal evaluations of these interventions are rare. The aim of the current study was to compare the effectiveness of a regular and an extended civic orientation course with added health communication and examine whether the latter would improve self-rated health and psychological well-being, health literacy and social capital among newly settled refugee migrants in Sweden. Pre- and post-assessment questionnaires were collected from the intervention group receiving the extended course (n = 143) and a control group receiving the regular course (n = 173). Linear mixed models and chi-square analyses showed a significant increase with a small effect size (0.21) in health literacy in the intervention group. However, there were no significant changes in emotional and practical support, general self-rated health or psychological well-being. The findings indicate that added health communication provided embedded in the civic orientation course can increase health literacy. However, further longitudinal studies are needed to confirm the sustainability of the observed effect and examine whether these short-term improvements in health literacy translate to long-term advances in health and integration., (© The Author(s) 2024. Published by Oxford University Press.)
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- 2024
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40. Attachment and trauma-informed programme to support forcibly displaced parents of youth in Sweden: feasibility and preliminary outcomes of the eConnect Online programme.
- Author
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Kristen A, Salari R, Moretti M, and Osman F
- Subjects
- Humans, Female, Adolescent, Child, Male, Sweden, Feasibility Studies, Afghanistan, Somalia, Parenting psychology, COVID-19
- Abstract
Objectives: To assess the feasibility, acceptability and the impact of an online parenting programme for forcibly displaced parents of adolescents., Design: The study was a single-arm feasibility study using pre-intervention post-intervention and follow-up assessments., Setting: Participants were recruited from municipality-based activities for refugee parents in a small city in the south of Sweden., Participants: Participants were forcibly displaced parents (n=23; 47.8% maternal figures) of youth (n=23; 8-17 years old; 26.1% female) from Syria, Afghanistan and Somalia participating in an online parenting programme ( eConnect )., Intervention: eConnect is an attachment-based and trauma-informed parenting intervention and was delivered over the course of 10 weekly sessions., Primary and Secondary Outcome Measures: Feasibility was assessed by programme enrolment, attendance, completion and acceptability of the online platform and cultural fit of the programme. Primary outcome measures were programme impact on youth mental health problems. Secondary outcome measures were programme impact on family functioning and parent-child attachment insecurity., Results: The eConnect programme was highly feasible in terms of overall enrolment (100%), attendance (89.6%) and retention rates (100%). The online platform was acceptable, with mixed feedback primarily related to the access and usage of technology. Cultural fit of the programme was acceptable. Youth mental health problems ( η
2 =0.29) and family functioning significantly improved ( η2 =0.18) over the course of the programme. Unexpectedly, parent reports of youth attachment insecurity significantly worsened ( η2 =0.16)., Conclusions: The findings suggest that the online delivery of Connect was a promising way to reduce barriers to service access and improve mental health problems and family functioning among forcibly displaced parents and their children during COVID-19. Future research is needed to explore the acceptability and impact of this programme post-COVID-19, and to develop culturally tailored and psychometrically sound measures for parent and youth reports of attachment., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)- Published
- 2023
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41. Efficacy of Herbal Medicines on Lung Function in Asthma: a systematic review and meta-analysis of randomized controlled trials.
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Derakhshan A, Sadeghi M, Asnaashari AM, Dehghani M, Salari R, Khadem-Rezaiyan M, Mirsadraee M, Saeidinejat S, Jalali S, and Jalali S
- Abstract
Objectives: The present study was designed to conduct a comprehensive systematic review and meta-analysis to assess the efficacy of herbal medicines as add-on therapy on lung function in asthmatic patients., Methods: A comprehensive search of online databases was performed up to December 2021 to identify randomized controlled trials that used orally herbal preparations for asthma as add-on therapy. Studies were assessed for methodological quality using the Cochrane Collaboration's Risk of Bias tool. The main outcome was percent predicted value of forced expiratory volume (% predicted FEV1). Pooled weighted mean difference (WMD) estimate with corresponding 95% confidence interval (CI) was calculated using inverse-variance weights method while random effects meta-analysis was used, taking into account clinical and conceptual heterogeneity., Results: As a result, 1,525 studies were identified. 169 studies were reviewed in-depth and 23 studies met our systematic review inclusion criteria. Finally, nine randomized controlled trials were included in the meta-analysis. Findings indicated that use of herbal medicines in patients with asthma significantly improved % predicted FEV1 (WMD 3.73, 95% CI 1.76-5.70), with no evidence for significant heterogeneity (p = 0.56 [Q statistic], I
2 = 0.0%). In subgroup analysis by age, improvement in % predicted FEV1 was higher and significant in adults (WMD 5.16; 95% CI 2.68-7.63) compared to children (WMD = 1.27; 95% CI -1.98-4.51). Sensitivity analysis showed the significant effect of herbal medicine consumption on improving FEV1 was consistently (range of summary WMDs 3.27-4.59), indicating that the meta-analysis model was robust. There was no evidence of publication bias both visually and statistically., Conclusion: Findings support, the complementary use of herbal medicines resulted in significant improvement in the lung function compared to standard treatment in asthmatic patients with no considerable adverse events. This improvement is more likely to be observed amongst adults., Competing Interests: CONFLICTS OF INTEREST The authors declared there were no conflicts of interest related to the study., (© 2023 Korean Pharmacopuncture Institute.)- Published
- 2023
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42. "Putting words to their feelings"- civic communicators' perceptions and experiences of an in-depth course on mental health for newly settled refugee migrants in Sweden.
- Author
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Al-Adhami M, Wångdahl J, Salari R, and Åkerman E
- Subjects
- Humans, Mental Health, Sweden, Emotions, Transients and Migrants, Refugees psychology
- Abstract
Background: Newly settled refugee migrants face psychological stressors stemming from pre-, during- and post-migration experiences. In Sweden, mental health promotion is part of the health module in the civic orientation classes for newly settled refugee migrants. Training courses are offered to civic communicators and workshop leaders to facilitate communication about mental health; however, the training is seldom evaluated. In the current study, we aim to explore civic communicators' perceptions and experiences of an in-depth mental health training course in relation to observed needs among newly settled refugee migrants., Method: We interviewed ten civic communicators that had partaken in the in-depth training course on mental health. All respondents had prior migratory experience and worked as civic communicators in their native languages. The interviews were semi-structured and data were analyzed using thematic analysis., Results: Three themes were identified: (1) Intertwined mental health needs related to migration, (2) Multi-layered barriers to addressing mental health, and (3) Becoming aware of the mental health journey. One overarching theme was arrived at through synthesizing the three themes 'Acquired new tools to lead reflective conversations about mental health and well-being'., Conclusion: The in-depth mental health training course led to the attainment of new knowledge and new tools enabling civic communicators to lead reflective conversations about mental health and well-being with newly settled refugee migrants. Mental health needs were related to pre- and post-migration experiences. Barriers to talking about mental health included stigma and a lack of arenas to promote the mental health of refugee migrants. Increasing knowledge among civic communicators can facilitate the promotion of mental self-help capacity and resilience among newly settled refugee migrants., (© 2023. The Author(s).)
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- 2023
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43. NICU parents' mental health: A comparative study with parents of term and healthy infants.
- Author
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Persson C, Ericson J, Salari R, Eriksson MH, and Flacking R
- Subjects
- Female, Humans, Infant, Infant, Newborn, Pregnancy, Infant, Premature, Mothers psychology, Male, Adult, Infant Care, Intensive Care Units, Neonatal, Mental Health, Parents psychology
- Abstract
Aim: To compare mental health in parents of preterm/ill infants and parents of term and healthy infants before birth and 1 month after hospital discharge., Methods: A comparative cohort design was used. In total 439 parents from six neonatal intensive care units (NICUs) and 484 parents from four maternity units (MUs) in Sweden answered a survey 1 month after discharge., Results: Parents in neonatal units experienced significantly more psychologically traumatic births and rated their health and the health of their infants less favourably the first week after delivery than parents in MUs. In the neonatal units, both parents had better possibilities to stay together with the infant during hospital stay. There was no difference between the NICU and MU groups in postpartum depressive symptoms 1 month after discharge. Experiencing a traumatic birth was not related to an increased risk of perinatal depressive symptoms (Edinburgh Postnatal Depression Scale ≥13) for mothers in NICUs. In contrast, the risk of depression increased for mothers in MUs., Conclusion: Family togetherness, parent-infant closeness and emotional support at NICUs may contribute to the positive outcome. Further studies are needed to assess the long-term effects of how family togetherness and closeness influence families long term., (© 2023 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.)
- Published
- 2023
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44. Perovskite quantum dots as a chemiluminescence platform for highly sensitive assay of cefazolin.
- Author
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Salari R, Amjadi M, and Hallaj T
- Subjects
- Luminescence, Cefazolin, Ferrous Compounds, Quantum Dots
- Abstract
This paper reports on a chemiluminescence (CL) probe consist of CsPbBr
3 quantum dots (QDs) in organic phase together with Fe(II) and K2 S2 O8 in aqueous medium for the highly selective and sensitive determination of the antibiotic, cefazolin (CFZ). The CsPbBr3 perovskite QDs prepared by the ligand assisted reprecipitation method, exhibit a narrow fluorescence at 533 nm under 460 nm excitation with a high quantum yield (42 %). The Fe(II) - S2 O8 2- as an ultra-weak CL system is converted to a rather strong CL sensing platform in the presence of organic-phase CsPbBr3 QDs. It was observed that CFZ exerts an enhancement effect on the CL signal of the designed probe in the linear range of 25 - 300 nM, with a low limit of detection (9.6 nM). The introduced sensor has broad application prospects in biosensing, food detection, and other fields with recovery ranging from 94 to 106 %., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier B.V. All rights reserved.)- Published
- 2023
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45. Herbal Therapies for Weight Gain and Metabolic Abnormalities Induced by Atypical Antipsychotics: A Review Article.
- Author
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Naghibi H, Salari R, Yousefi M, Khadem-Rezaiyan M, Ghanbarzadeh MR, and Fayyazi Bordbar MR
- Subjects
- Humans, Animals, Olanzapine therapeutic use, Weight Gain, Antipsychotic Agents adverse effects, Metabolic Syndrome chemically induced, Metabolic Syndrome drug therapy, Schizophrenia drug therapy
- Abstract
Psychosis is a state of mind that makes it difficult to determine what is real and what is not. Psychosis can have serious negative effects. Like many psychiatric phenomena, psychosis has a variety of causes, such as schizophrenia, bipolar disorder, and psychotic depression. Antipsychotic medications, psychotherapy, and social support are the most common treatments. Antipsychotic drugs reduce the symptoms of psychosis by changing brain chemistry. Based on the mechanism of action, antipsychotics have two groups, typical and atypical. Most people who take antipsychotics experience side effects. People taking typical antipsychotics tend to have higher rates of extrapyramidal side effects, but some atypical drugs, especially olanzapine, are associated with the risk of significant weight gain, diabetes, and metabolic syndrome, which, in turn, increases the risk of atherosclerotic cardiovascular disease and premature death. Physical exercise, diet regimen, psychoeducation, monotherapy, or switching to an alternative antipsychotic are strategies to correct metabolic aberrates in atypical antipsychotic users. In light of several successful studies on the use of medicinal plants to control metabolic syndrome, this article briefly reviews the studies on some herbal medications for the management of metabolic disorders associated with atypical antipsychotics and discusses probable mechanisms. Therefore, we searched the Cochrane, Scopus, PubMed, and Google Scholar databases for works published before July, 2022, on the effect of herbal medications on antipsychotic-related metabolic abnormalities in animals or humans. We recommend that some herbal medicines may be efficient for regulating the metabolic changes related to atypical antipsychotics due to their multipotential action, and more efforts should be made to make herbal drug treatments more effective. We hope this review will be a reference for research on developing herbal therapeutics for metabolic alterations in antipsychotic customers., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
- Published
- 2023
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46. Achievements in Hypothyroidism Treatment with Herbal Medicine: A Systematic Review of Randomized Controlled Trials.
- Author
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Javidi N, Khorasani ZM, Salari R, Niroumand S, and Yousefi M
- Subjects
- Humans, Randomized Controlled Trials as Topic, Plant Extracts therapeutic use, Thyrotropin therapeutic use, Cholesterol, Hypothyroidism drug therapy, Hypothyroidism diagnosis, Plants, Medicinal
- Abstract
Background: Hypothyroidism is a common endocrine disease in the world that causes morbidity and mortality due to its association with metabolic diseases, especially in old age, and longterm treatment with levothyroxine causes many side effects for patients. Treatment with herbal medicine can regulate thyroid hormones and prevent side effects., Objective: The purpose of this systematic review is the evaluation of the effect of herbal medicine on the signs and symptoms of primary hypothyroidism., Methods: PubMed, Embase, Google Scholar, Scopus, and Cochrane Central Register of Controlled Trials were searched until 4 May, 2021. We selected randomized clinical trials (RCTs) that have assessed the effect of herbal medicine on hypothyroidism., Results: Out of 771 articles, 4 trials with 186 participants were included. In one study, Nigella sativa L. caused a significant decrease in weight (P=0.004) and body mass index (BMI) (P=0.002). TSH levels were reported to be decreased and T3 increased in the treatment group (P =0.03) (P=0.008), respectively. In another study on Nigella sativa L., results did not show a significant difference between the two groups (p=0.02). A significant decrease in total cholesterol (CHL) and fasting blood sugar (FBS) was reported in participants with negative anti-thyroid peroxidase (anti-TPO) antibodies. In patients with positive anti-TPO antibodies, a significant increase in total cholesterol and FBS was observed in the intervention group (p=0.02). In the third RCT, T3 in the ashwagandha group at 4 and 8 weeks significantly increased by 18.6% (p=0.012) and 41.5% (p < 0.001), respectively. A noticeable increase was found in the T4 level from baseline by 9.3% (p= 0.002) and 19.6% (p < 0.001) at 4 and 8 weeks, respectively. TSH levels fell remarkably in the intervention group compared to placebo at 4 weeks (p <0.001) and 8 weeks (p <0.001), respectively. In the last article selected, Mentha x Piperita L. showed no significant difference in fatigue scores between intervention and control groups at the midpoint (day 7), while fatigue scores improved in the intervention group in all subscales compared to the control group on day 14., Conclusion: Some herbal remedies, including Nigella sativa L., ashwagandha, and Mentha x Piperita L., can improve the signs and symptoms of primary hypothyroidism, but using a more extensive and advanced methodology will provide us with more complete results., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
- Published
- 2023
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47. A cross-sectional study of health and well-being among newly settled refugee migrants in Sweden-The role of health literacy, social support and self-efficacy.
- Author
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Al-Adhami M, Berglund E, Wångdahl J, and Salari R
- Subjects
- Humans, Cross-Sectional Studies, Sweden, Self Efficacy, Social Support, Transients and Migrants, Health Literacy, Refugees psychology
- Abstract
Structural barriers such as inadequate housing, lack of employment opportunities, and discrimination are known to adversely affect the health of newly settled refugee migrants. However, these barriers remain largely unresolved and unaddressed. Thus, there is a need to better understand how other factors, such as individual-level health resources, may influence health and mitigate ill health in the early post-migration phase. In this study, we aimed to explore the relationship between health outcomes and individual health resources including health literacy, social support, and self-efficacy in newly settled refugee migrants. Survey data was collected from 787 refugee migrants in Sweden. Logistical regression analysis showed that limited health literacy, lack of emotional support, and low self-efficacy were consistently associated with poor health outcomes. Demographic variables such as gender, education, and type of residence permit were not as imperative. Individual-level health resources may play an important role in the general and psychological well-being of newly settled migrants. Promoting health literacy and facilitating the attainment of social support may buffer for structural challenges in the establishment phase and enhance the prospects of later health and social integration., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2022 Al-Adhami et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
- Published
- 2022
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48. Evaluation of a Polyherbal Formulation on the Management of Migraine Headaches due to Functional Dyspepsia: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial.
- Author
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Anushiravani M, Hosseini SM, Nikkhah K, Niroumand S, Derakhshan AR, Salari R, Gholampour A, and Askari VR
- Abstract
A holistic concept based on traditional Persian medicine (TPM) describes a headache with a gastrointestinal (GI) origin (gastric-headache). Although the neurological manifestations of this headache are similar to those of other headaches, its etiology is different. Considering its simultaneous effects on the brain and GI system, a formulation was designed based on this concept. This study aimed to determine the safety and efficacy of the designed formulation on migraine headache (MH) associated with functional dyspepsia (FD). A total of 75 diagnosed cases of MH patients with concurrent FD were randomly divided equally into 3 groups: (i) the polyherbal formulation, sodium valproate (VPA), and amitriptyline group, (ii) VPA, amitriptyline, and polyherbal formulation placebo group, and (iii) the polyherbal formulation and VPA placebo group. The primary outcomes, including frequency, duration, and severity of MH attacks, were measured at baseline and weeks 4, 8, and 12. However, secondary outcomes, including the Headache Impact Test 6 (HIT-6) Questionnaire and Parkman's score, were evaluated at baseline and end of treatment. The frequency, duration, and severity of migraine ( P < 0.001 for all cases), HIT-6 ( P < 0.001 for all cases), and FD ( P < 0.001 for all cases) scores at the end of treatment showed a significant decrease in the 3 groups compared to the baseline. However, the differences in those variables between the 3 groups were not significant at the end of the study. The polyherbal formulation alone may improve the symptoms of migraine patients and other groups. This effect could be due to improving digestion and FD in migraine patients., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2022 Majid Anushiravani et al.)
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- 2022
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49. Body MRI: Imaging Protocols, Techniques, and Lessons Learned.
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Shetty AS, Fraum TJ, Ludwig DR, Hoegger MJ, Zulfiqar M, Ballard DH, Strnad BS, Rajput MZ, Itani M, Salari R, Lanier MH, and Mellnick VM
- Subjects
- Humans, Contrast Media, Diffusion Magnetic Resonance Imaging, Liver pathology, Magnetic Resonance Imaging methods, Artifacts
- Abstract
Body MRI has evolved from a niche subspecialty to a standard modality in the practice of abdominal radiology. However, the practicing radiologist may feel uncomfortable interpreting body MRI studies owing to a lack of case volume and inconsistent exposure. The authors highlight teaching points and subtleties central to better acquisition and interpretation of body MRI studies. Appropriate contrast agent selection and arterial phase acquisition timing provide greater diagnostic certainty in answering common clinical questions at liver MRI, such as assessing cirrhosis and evaluating focal liver lesions. Clinically relevant artifacts and physiologic phenomena, such as magnetic susceptibility and transient hepatic intensity difference, must be recognized and appropriately used when reading a study. Fat within organs and lesions is commonly encountered at body MRI. The authors discuss the nuances of common and uncommon entities, how to address fat suppression failure, assessment of bone marrow at body MRI, and an organized approach to fat-containing renal and adrenal masses. Motion artifacts are more commonly encountered at body MRI than at MRI of other anatomic regions, and understanding the various techniques, their benefits, and trade-offs will aid the body imager in protocol design and moving beyond "nondiagnostic" examinations. Challenging anatomic sites to evaluate at body MRI are reviewed. Finally, the authors offer tips for accurate interpretation of diffusion-weighted imaging, hepatobiliary phase imaging, and posttreatment imaging studies. By reviewing this article, the abdominal imager will be better prepared to perform and interpret body MRI studies confidently and accurately. An invited commentary by Kalb is available online. Online supplemental material is available for this article.
© RSNA, 2022.- Published
- 2022
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50. The Effect of Glasthma Syrup in Asthma: a study protocol for a triple-blind randomized controlled trial.
- Author
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Derakhshan AR, Saeidinejat S, Khadem-Rezaiyan M, Asnaashari AM, Mirsadraee M, Salari R, Jabbari-Azad F, Jalali S, and Jalali S
- Abstract
Objectives: Asthma is a chronic disease, and the demand for herbal medicines in this field has increased in recent years. The new findings highlight the role of the gut-lung axis in the pathophysiology of asthma. Hence, this study will evaluate the safety and efficacy of Glasthma syrup, an herbal formula based on Persian medicine, in improving asthma and regulating intestinal permeability. The formula consists of five herbal ingredients that have anti-inflammatory effects on the respiratory tract, also known as gut tonics., Methods: The study will be conducted as a placebo-controlled, triple-blind, randomized trial. It will consist of a 4-week intervention followed by a 4-week follow-up period. The target sample size is 20 patients with moderate asthma aged 18 to 60 years. Eligible participants will be randomly assigned to either the experimental group or the control group in equal numbers. Patients in the experimental group will take Glasthma syrup (7.5 mL, twice a day), while patients in the control group will take a matching placebo. Both groups will receive a 4-week combination of a long-acting beta2 agonist and a leukotriene modulator as standard of care. Inhaled corticosteroids can be used as rescue medication as needed., Results: The primary outcomes are asthma symptom scale, lung function, and intestinal permeability. Secondary outcomes include quality of life, symptom recurrence rates, and blood tests. A safety assessment will also be conducted during the trial., Conclusion: In this trial, the effects of Glasthma syrup in patients with moderate asthma will be examined. The study will also assess the effects of the formulation on the gut-lung axis by simultaneously monitoring the gut permeability index, asthma symptoms, and lung function., Competing Interests: CONFLICT OF INTEREST The authors declare no conflict of interests., (© 2022 Korean Pharmacopuncture Institute.)
- Published
- 2022
- Full Text
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