Search

Background: For a periodontist, treating recession is always a proud moment and a challenging task. The current trial aimed at comparing and clinically evaluating semilunar coronally repositioned flap (SCRF) and coronally advanced flap (CAF) procedures combined with platelet-rich fibrin (PRF) in the management of Miller’s Class I recession defects. Materials and Methods: Thirty-six recession sites were randomly divided into the CAF or SCRF groups. Gingival thickness (GT), root coverage percentage (%RC), plaque index (PI), gingival bleeding index (GBI), and clinical attachment level (CAL) were measured at baseline and 3 and 6 months. Recession height (RH), recession width (RW), and width of keratinized tissue (WKT) were also measured. With significance set at p=/ 0.05). Further, intergroup comparison showed no significant difference in both the groups for all the parameters except for %RC where significance was reported at 1 month (P = 0.015*) and 3 months (P = 0.013*) when compared from baseline to 6 months. Conclusion: Root coverage is better in CAF with PRF than SCRF with PRF, in the treatment of gingival recession. PRF helped in soft-tissue healing and increased in GT.

Snow-induced disasters pose significant risks in mountainous regions. Accurate visibility assessment is crucial for informed decision-making and disaster preparedness. This paper presents an innovative approach that integrates theoretical literature with practical application using augmented reality (AR) to address this challenge. The proposed system, named Him-Drishti, harnesses the established correlation between snowfall intensity and visibility to create a predictive model. By incorporating user-input snowfall intensity predictions, the Him-Drishti AR application dynamically overlays real-time visibility simulations onto the physical environment. Moreover, the use of smartphones further amplifies the practicality of this innovative solution, making the AR application a handy tool, even in the most challenging terrain. This intuitive visualization empowers stakeholders with a comprehensive understanding of potential risks, facilitating informed decisions and optimized disaster response strategies. Through AR visualization, stakeholders, emergency responders, and local authorities gain valuable insights into visibility conditions, enabling them to make informed decisions, take proactive measures, and allocate resources effectively. This study not only enhances the understanding of snow-related disasters but also demonstrates the capacity of AR in disaster management and risk reduction.

Abstract Background Endogenous substances of krill oil (KO) are lipophilic in nature and have clinical significance viz. DHA/EPA, phospholipids and astaxanthin. To improve the nanodispersibility of endogenous substances of KO, a self-nanoemulsifying system (SNE) was developed. Results Ternary phase behaviour of KO was explored in ethanol (ET); propylene glycol, (PG); and PEG600 using Tween80 and Tween20 as surfactants. PEG600 induced the self-nanoemulsification of KO and yielded one phase region (OPR); dilution lines (KO/Smix fraction containing PEG600) traversed across OPR, produced a fully dilutable nanoemulsion system. PEG600-based nanoformulations (NFs) of KO underwent phase transformation via percolation behaviour in nanostructure domains (86–207 nm). PEG600 induced ternary phase behaviour of KO as revealed from rheological data (higher eta values), refractive index (nonlinear) and conductivity (bimodal) patterns. Induced phase transformation could be an interaction between aqueous phase and KO/Tween20 in PEG600 environment; generating highly viscous domains of low electrical conductivity. NFs offered antioxidant activity over corresponding coarse systems (p

Ultrasonography (USG) is utilized for the diagnostic and interventional management of patients with carpal tunnel syndrome (CTS). The management of patients with severe and/or refractory CTS includes the surgical (open/endoscopic) release of transverse carpal ligament. With the advancements in the resolution of USG, the release of transverse carpal ligament can be done safely with the help of transecting/cutting devices. We discuss the technical report on the principle of percutaneous thread carpal tunnel release with the help of surgical grade thread.

Abstract The swift progress in wearable technology has accentuated the need for flexible power systems. Such systems are anticipated to exhibit high efficiency, robust durability, consistent power output, and the potential for effortless integration. Integrating ultraflexible energy harvesters and energy storage devices to form an autonomous, efficient, and mechanically compliant power system remains a significant challenge. In this work, we report a 90 µm-thick energy harvesting and storage system (FEHSS) consisting of high-performance organic photovoltaics and zinc-ion batteries within an ultraflexible configuration. With a power conversion efficiency surpassing 16%, power output exceeding 10 mW cm–2, and an energy density beyond 5.82 mWh cm–2, the FEHSS can be tailored to meet the power demands of wearable sensors and gadgets. Without cumbersome and rigid components, FEHSS shows immense potential as a versatile power source to advance wearable electronics and contribute toward a sustainable future.

Extramedullary plasmacytoma (EMP) is an uncommon tumor marked by the monoclonal growth of plasma cells without the characteristics of multiple myeloma. EMP represents 3% of all plasma cell tumors. An 89-year-old male patient with hypertension was admitted to our tertiary care hospital with uncontrolled unilateral epistaxis. After a year and a half of recurring epistaxis, the patient's bleeding became more frequent and could no longer be controlled with nasal packing. Angiofibroma was suspected as the initial differential diagnosis, and angiofibroma embolization was performed. The patient experienced difficulty swallowing and slurred speech and was diagnosed with an ischemic stroke. However, antiplatelet and tranexamic acid medications were contraindicated due to bleeding risks. The patient underwent functional endoscopic sinus surgery, and unexpectedly, histology results revealed a plasmacytoma. After surgery, the patient remained stable and was discharged for further management.

Background Liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, has demonstrated efficacy in improving glycemic control and promoting weight loss in clinical trials. However, real-world data from diverse populations, particularly from South Asia, are limited. The study aims to evaluate the long-term efficacy and safety of liraglutide in a real-world setting among Pakistani patients with type 2 diabetes mellitus (T2DM).Methodology A retrospective cohort study of 624 patients initiated on liraglutide was conducted. Data were collected at baseline and 6, 12, 18, and 24 months. Primary outcomes were HbA1c and weight changes. Secondary outcomes included fasting plasma glucose, lipid profile, and blood pressure. Statistical analyses were performed using appropriate methods.Results In study population the mean HbA1c reduction of −1.45 ± 0.67% was observed at 24 months, with 30.6% achieving HbA1c ≤ 7.5%. A rapid and sustained weight loss of −7.51 kg was achieved, with 27.2% experiencing ≥5% weight loss. Additionally, liraglutide led to a significant reduction in LDL cholesterol, with 46.7% of patients achieving a ≥ 10% reduction at 24 months. Liraglutide was well-tolerated, with a low discontinuation rate of 4.6%.Conclusion Liraglutide demonstrated sustained efficacy and safety in a diverse Pakistani population with T2DM, regardless of baseline characteristics. These findings support the use of liraglutide as an effective treatment option for T2DM in real-world clinical practice.

Adherence of Bacillus cereus spores to dairy industry equipment is a serious problem, causing food spoilage and, occasionally, outbreaks of foodborne diseases. Antimicrobial essential oils (EOs) have been proposed as an alternative to synthetic disinfectants due to their environmentally friendly properties. The aim of this study was to assess the effect of Cymbopogon winterianus and Juniperus phoenicea EOs on planktonic and adherent B. cereus spores to stainless steel surfaces. Eleven strains of B. cereus were used in this study. The chemical composition of the C. winterianus and J. phoenicea oils was analyzed by gas chromatography (GC)/mass spectrometry (MS). Ninety components were identified for C. winterianus, being geranial (37 %), neral (29 %), beta-myrcene (16 %) and geraniol (4 %) the most abundant constituents. Twelve components were identified for J. phoenicea, being alpha-pinene (65 %) the most abundant constituent. The results of the minimal inhibitory concentration and minimal bactericidal concentration revealed that C. winterianus was the most effective EO (p

This study investigates how the Global Financial Crisis has affected the weak-form Efficient Market Hypothesis (EMH) on the stock prices of sixteen nations throughout the globe based on a suite of Fourier unit root tests. Considering the smooth structural breaks, we employed the Fourier-based unit root tests to assess the weak-form efficient market hypothesis. We used multiple frequency datasets of global financial stock market indexes that span over 20 years to have comprehensive analysis and robustness in the results. The study is performed from distinct sub-sample periods of the global financial crisis, including the pre-crisis period (2000–2007), the crisis and post-crisis period (2008–2020), and the overall sample period (2000–2020). We observed seven stock markets in the total sample period and twelve in the pre-crisis period, which were weak-form efficient across different frequency data sets. During the crisis and post-crisis period, just four out of sixteen stock market indexes were found to be weak in efficiency based on Fourier unit root tests. Given the superior properties of the Fourier unit root tests, this study reiterates that investors may receive a stream of arbitrage benefits in all markets due to the inefficiency of these countries. We offer investment implications that enable forecasting future stock price changes based on past performance and creating trading methods that produce anomalous profits.

The COVID-19 crisis has significantly impacted the global economy, instantly triggering an effect on stock market stability forcing companies to adapt to the uncertainty of economic conditions to survive. Implementing enterprise risk management (ERM), corporate governance (CG), and sustainability can help companies improve or maintain their performance. Companies faced the prospect of a stock market crash amid the crisis' chaos. This study aims to analyze the effect of ERM, CG, and sustainability on performance moderated by market crashes in companies listed on the LQ45 Index Indonesia Stock Exchange (IDX) during the 2020 period when the composite stock price index (IHSG) crashed. Thirty-three companies served as the study's samples, while secondary data from partial least squares (PLS) and descriptive analysis were employed. The findings suggest that ERM and CG have a significant impact on sustainability and also have an insignificant impact on performance. Furthermore, sustainability has a significant effect on performance, and market crashes have a moderating effect that improves the impact of ERM on performance.

This research aims to explore the influence of Green Banking and Corporate Governance on Company Value through the mediation of Competitive Advantage in Conventional Commercial Banks listed on the Indonesia Stock Exchange (IDX) from 2017-2022. The study employs a quantitative method with a positivistic approach, involving a sample of 41 Conventional Commercial Banks listed on the IDX. This research uses a purposive sampling technique with inclusion criteria involving banks registered on the IDX, publishing financial reports, and providing the necessary data. Secondary data is in the form of banking financial reports for 2017-2022. Hypothesis testing uses quantitative statistical analysis with Structural Equation Modeling (SEM). The research results show that Green Banking and Corporate Governance significantly affect Competitive Advantage and Company Value. Competitive advantage and company value have a significant favourable influence. The findings of this research can contribute to a deeper understanding of the relationship between Green Banking, Corporate Governance, Competitive Advantage and Company Value in the context of the conventional banking industry in Indonesia.

The growing population and rapid urbanization are significant challenges for Indian cities. Pune City generates nearly 2,258 tonnes of waste per day. Pune’s informal waste sector has demonstrated remarkable efficiency, cost-effectiveness, and self-sustainability. Moreover, it contributes to favorable economic and social outcomes for the city. With the support of the self-help group SWaCH Seva Sahakari Sanstha Maryadit, Pune, the municipal solid waste management model has successfully achieved a remarkable 95 percent segregation rate. Implementing the Pune municipal solid waste management model showcases the active and efficient engagement of informal waste workers in the collection and resource utilization process. This underscores the possibility of favorable economic, social, and environmental results stemming from collaborations between municipalities and waste pickers. This paper looks at the role of SWaCH in line with Pune Municipal Corporation towards the present waste management system. Primarily reliant on labor, this model accomplishes recycling tasks at a notably lower cost compared to conventional mechanized and centralized waste management approaches. It can also accomplish high recycling levels and relatively considerable plastic waste segregation. Promoting the retrieval of valuable materials, especially plastics, for local and global recycling enterprises actively contributes to the advancement of a circular urban waste management approach. The objective of this research is to explore and provide a realistic understanding of Pune’s current status of waste generation, collection, transportation, and disposal. Apart from the SwaCH-PMC model, the paper also focuses on plastic waste recycling, the Red Dot Campaign towards sanitary waste, and household e-waste management in Pune.

Abstract Bacteria employ quorum sensing as a remarkable mechanism for coordinating behaviors and communicating within their communities. In this study, we introduce a MATLAB Graphical User Interface (GUI) that offers a versatile platform for exploring the dynamics of quorum sensing. Our computational framework allows for the assessment of quorum sensing, the investigation of parameter dependencies, and the prediction of minimum biofilm thickness required for its initiation. A pivotal observation from our simulations underscores the pivotal role of the diffusion coefficient in quorum sensing, surpassing the influence of bacterial cell dimensions. Varying the diffusion coefficient reveals significant fluctuations in autoinducer concentration, highlighting its centrality in shaping bacterial communication. Additionally, our GUI facilitates the prediction of the minimum biofilm thickness necessary to trigger quorum sensing, a parameter contingent on the diffusion coefficient. This feature provides valuable insights into spatial constraints governing quorum sensing initiation. The interplay between production rates and cell concentrations emerges as another critical facet of our study. We observe that higher production rates or cell concentrations expedite quorum sensing, underscoring the intricate relationship between cell communication and population dynamics in bacterial communities. While our simulations align with mathematical models reported in the literature, we acknowledge the complexity of living organisms, emphasizing the value of our GUI for standardizing results and facilitating early assessments of quorum sensing. This computational approach offers a window into the environmental conditions conducive to quorum sensing initiation, encompassing parameters such as the diffusion coefficient, cell concentration, and biofilm thickness. In conclusion, our MATLAB GUI serves as a versatile tool for understanding the diverse aspects of quorum sensing especially for non-biologists. The insights gained from this computational framework advance our understanding of bacterial communication, providing researchers with the means to explore diverse ecological contexts where quorum sensing plays a pivotal role.

This study investigates the impact of corporate governance attributes, particularly the board of directors and audit committee, on the firm value of property and real estate companies in Indonesia. Additionally, this study introduces the novel exploration of audit report lag as a mediating factor in the relationship between corporate governance and firm value. Utilizing a quantitative approach, secondary data were extracted from the financial statements of property and real estate companies. The study employed a purposive sampling technique, resulting in a sample of 26 companies listed on the IDX for 2018-2022. In this study, inferential statistical analysis is conducted using the Partial Least Squares (PLS) based Structural Equation Modeling (SEM) technique. The findings reveal that corporate governance attributes, including the board of directors and audit committee, significantly enhance firm value. Furthermore, audit report lag mediates the effect of the audit committee on firm value but does not mediate the effect of the board of directors. This implies that while the audit committee plays a crucial role in reducing audit report lag, thereby enhancing firm value, the board of directors may influence firm value through different mechanisms not captured by audit report lag.

Shaylen Foley,1 Danya E Keene,1 Roman Shrestha,2– 4 Shan-Estelle Brown,5 Kamal Gautam,2 Ryan A Sutherland,3 Francesca Maviglia,3 Rumana Saifi,4 Jeffrey A Wickersham3,4 1Department of Social and Behavioral Sciences, Yale School of Public Health, Yale University, New Haven, CT, USA; 2Department of Allied Health Sciences, University of Connecticut, Storrs, CT, USA; 3Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, CT, USA; 4Centre of Excellence for Research in AIDS (CERiA), Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 5Department of Anthropology, Rollins College, Winter Park, FL, USACorrespondence: Shaylen Foley, 135 College Street, Suite 323, New Haven, CT, 06510, USA, Tel +419 343-4606, Email shaysf@gmail.comIntroduction: Pre-exposure prophylaxis (PrEP) is an effective method for prevention of HIV transmission. Female sex workers (FSW) in Malaysia are at substantially increased risk of acquiring HIV compared to the general female population, yet little is known about this population’s current HIV prevention practices or acceptance of PrEP. This study aims to inform the culturally relevant implementation of PrEP through the qualitative exploration of (1) the potential need for PrEP in this population and (2) the factors that determine FSW willingness to use oral PrEP.Methods: In-depth, semi-structured interviews (n = 30) were conducted with FSW in English, Malay, or Tamil. Transcribed and translated interviews were analyzed using a grounded theory approach.Results: FSW express positive interest in PrEP but prefer it as a supplement to condoms, not a replacement. Perceived challenges to PrEP use include cost, adherence, and side effects.Conclusion: The findings suggest that in combination with condom use, PrEP may be an acceptable method of HIV prevention. Effective PrEP rollout may also include condom promotion using a peer-driven model, cost subsidies, and sex work harm reduction and empowerment components.Keywords: sex work, HIV, pre-exposure prophylaxis, Malaysia

Power systems protection has become more vital in recent years to ensure stability, reliability, security, and power quality due to the exponential growth of grid-connected photovoltaic (GCPV) systems. As a result, several nations have set new grid codes for the grid integration of PV plant installations to overcome these concerns. Investigating Fault Ride Through (FRT) capacity is one of the primary criteria for grid codes. For 3-phase GCPV systems, fault detection and classification approaches are proposed in this study. Firstly, different faults that occurred in the GCPV system are categorized and compared, with the critical and analytical evaluation of grid codes, particularly FRT requirements such as Low Voltage Ride Through (LVRT) and High Voltage Ride Through (HVRT) for different nations. Further, a detailed classification and a comparison of the existing FRT techniques are presented for better control methods based on system complexity, detection accuracy, and other evolutionary criteria. To ensure smooth grid operation, accurate fault detection and condition monitoring of the systems are required. This paper discusses a machine learning (ML) based technique for detecting faults in 3-phase GCPV systems. Multi-peak phenomena caused by FRT capabilities and anti-islanding detection are the main problems experienced while integrating a PV system into the local grid. The fault classification technique is developed using weighted K-nearest neighbor (WKNN) and fine Gaussian support vector machine (FGSVM) based ML approaches utilizing Wavelet Transform. The proposed ML-based findings show that the fault detection algorithm-based classification accuracy has significantly improved.

This study investigates the impact of company size on financial performance and company value, with a particular focus on the moderating role of IT innovation in the Indonesian commercial banking sector. Utilizing data from Category 4 commercial banks listed on the Indonesia Stock Exchange from 2016 to 2022, the study employs the Partial Least Squares (PLS) method facilitated by the WarpPLS package to analyze these relationships. The results demonstrate that both company size significantly enhance financial performance and company value. Furthermore, IT innovation is found to significantly moderate these effects, amplifying the positive impacts on company value. Specifically, IT innovation strengthens the relationship between financial performance and company value, reflecting its crucial role in modern banking operations. This research provides empirical evidence on the strategic importance of IT innovation in enhancing financial determinants and offers recommendations for integrating technological advancements in banking strategies to improve overall performance and value. The findings underscore the transformative potential of IT innovation in the financial sector, particularly in emerging markets like Indonesia. Recommendations for future research include exploring the long-term impacts of IT innovation on banking performance and its broader economic implications.

A key challenge in controlling deteriorating urban air quality is a lack of clear understanding of the regional emissions characteristics and their impact on human health. COVID-19 lockdown provided an opportunity to enhance understanding of background air quality. Towards this, we studied the effect of the lockdown on air pollutants level and associated health benefits in two contrasting urban cities of Eastern IGP, Asansol (industrial) and Kolkata (metropolitan), by analyzing data from 2019 to 2021. The outcomes revealed that the level of exceedance of air pollutants is usually higher in Asansol but significantly decreased in both cities during the lockdown period. Particle concentrations were reduced by 50–70 % compared to Pre-Lockdown and by 20–35 % against the same period in 2019. Kolkata witnessed a higher reduction in PM levels than Asansol. Diurnal variation comparison showed a higher reduction of particle levels during lockdown in the morning at Asansol while in the evening at Kolkata. The health benefits associated with the reduction in PM2.5 concentration were quantified using the BenMAP-CE model, which revealed that improving air quality, like during the lockdown period, would save annually 0.46 and 2.91 deaths per 100,000 persons in Asansol and Kolkata, respectively. Altogether, this study's outcomes provide essential insights to policymakers for regional factors associated to varying air quality and health benefits associated to improvement in air quality.

BackgroundGlobally, transgender women have been disproportionately affected by the HIV epidemic, including in Malaysia, where an estimated 11% of transgender women are living with HIV. Available interventions designed specifically to meet transgender women’s needs for HIV prevention are limited. Mobile health, particularly smartphone mobile apps, is an innovative and cost-effective strategy for reaching transgender women and delivering interventions to reduce HIV vulnerability. ObjectiveThis study aims to adapt a theory-based mobile health HIV prevention smartphone app, HealthMindr, to meet the unique needs of transgender women in Malaysia. We conducted theater testing of the HealthMindr app with transgender women and key stakeholders and explored barriers to transgender women’s uptake of HIV pre-exposure prophylaxis (PrEP). MethodsFrom February to April 2022, a total of 6 focus group (FG) sessions were conducted with 29 participants: 4 FG sessions with transgender women (n=18, 62%) and 2 FG sessions with stakeholders (n=11, 38%) providing HIV prevention services to transgender women in Malaysia. Barriers to PrEP uptake and gender-affirming care services among transgender women in Malaysia were explored. Participants were then introduced to the HealthMindr app and provided a comprehensive tour of the app’s features and functions. Participants provided feedback on the app and on how existing features should be adapted to meet the needs of transgender women, as well as any features that should be removed or added. Each FG was digitally recorded and transcribed. Transcripts were coded inductively using Dedoose software (version 9.0.54; SocioCultural Research Consultants, LLC) and analyzed to identify and interpret emerging themes. ResultsSix subthemes related to PrEP barriers were found: stigma and discrimination, limited PrEP knowledge, high PrEP cost, accessibility concerns, alternative prevention methods, and perceived adverse effects. Participants suggested several recommendations regarding the attributes and app features that would be the most useful for transgender women in Malaysia. Adaptation and refinement of the app were related to the attributes of the app (user interface, security, customizable colors, themes, and avatars), feedback, and requests for additional mobile app functional (appointment booking, e-consultation, e-pharmacy, medicine tracker, mood tracker, resources, and service site locator) and communication (peer support group, live chat, and discussion forum) features. ConclusionsThe results reveal that multifaceted barriers hinder PrEP uptake and use among transgender women in Malaysia. The findings also provide detailed recommendations for successfully adapting the HealthMindr app to the context of Malaysian transgender women, with a potential solution for delivering tailored HIV prevention, including PrEP, and increasing accessibility to gender-affirming care services.

In this case report, a 33-year-old male with a history of smoking presented with recurrent palpitations and chest discomfort. Holter monitoring revealed atrial flutter, and imaging showed a giant left atrial appendage aneurysm. Due to the risk of arrhythmias and thromboembolic events, surgical resection was performed successfully. This case underscores the importance of considering uncommon structural cardiac abnormalities in the evaluation of arrhythmia symptoms in young patients.

Abstract Introduction Mpox is a zoonotic viral disease that emerged in May 2022 and has since shown a high prevalence in non-mpox-endemic areas, resulting in an outbreak that caused more than 84,000 cases in 110 countries around the globe. Several vaccines are available to prevent the disease, and multiple studies have been conducted to assess the attitudes of different populations toward receiving the mpox vaccine. This study systematically reviews all the studies conducted on mpox vaccine acceptance/hesitancy among healthcare workers. Methods A systematic literature search was conducted through four electronic databases, including PubMed, Scopus, Web of Science, and Google Scholar, up to March 2023. Studies that described mpox vaccine acceptance/hesitancy among healthcare workers were included, and the data were extracted using a uniform extraction sheet. Following the extraction, the meta-analysis included ten studies with 7322 healthcare workers. Three researchers independently assessed the risk of bias in the included study using the Newcastle–Ottawa Scale (NOS). Results Ten studies were included in the review. This review indicates that the prevalence of mpox vaccine acceptance was 58.5%, and the prevalence of mpox vaccine hesitancy was 41.5%. There was a higher prevalence of acceptance in countries located in Asian and African areas compared to those in North America and Europe, estimated at 68% and 44.3%, respectively. Among the studies conducted solely among physicians, there was a high prevalence of mpox vaccine acceptance, at 77.1%, compared to 49% in studies that included all healthcare workers. Conclusion There is a significant variation in the prevalence of mpox vaccine acceptance among different populations. Further research is needed to identify the factors that contribute to this variation and to develop interventions to increase vaccine acceptance. In addition, it is important to promote research on mpox vaccine acceptance and hesitancy among healthcare workers in countries where data is limited. This research will help policymakers develop effective policies to increase acceptance and reduce the disease burden.

The demographic growth in East-Jerusalem and limited land availability due to Israeli planning policies have led to the emergance of haphazardly designed housing developments that prioritize profit over culturally and climatically responsive design solutions. As a result, traditional values are lost, and the impact of climate change is exacerbated. This study evaluates the housing environment in Jerusalem from social and climatic perspectives, using locally produced architectural design solutions to identify sustainable indicators. The study emphasizes the importance of building layouts and design principles that were developed by Jerusalemites in their early attempts to modernize while rooted in traditional values. Field and ethnographic research provides a comprehensive understanding of layout designs, decisions related to thermal comfort, and cultural values associated with the living environment during the early modernity phase. Morphological analysis of plan layouts identifies common design principles frequently employed in relation to climatic, social, and environmental factors. Additionally, the study conducts a systematic literature review of previous research to identify the approaches and methodologies used in detecting indicators of climate-responsive architectural design. These indicators are used alongside field analysis to evaluate and compare cases and identify problematic issues in contemporary housing development designs. The study presents guidelines for future sustainable developments based on locality.

Non-alcoholic fatty liver disease (NAFLD) is a significant consequence of metabolic dysfunction, often associated with changes in the intestinal microbiota. Prebiotics and probiotics have shown promise in NAFLD management. This study evaluated a silymarin-based herbal remedy with piperine and fulvic acid, alongside a probiotic blend of Bifidobacterium adolescentis, Bifidobacterium bifidum, Lactobacillus casei, and Lactobacillus rhamnosus. Using a NAFLD mouse model induced by a high-fat and high-fructose diet, we assessed biochemical parameters, liver function, glucose levels, and conducted histological analysis. Stool samples underwent 16S rRNA metagenomic analysis to explore changes in microbiota composition. Mice on the high-fat diet exhibited elevated lipids, liver enzymes, and glucose, with reduced high-density lipoprotein levels (with p value

The incidence of venous thromboembolism (VTE) in cancer patients is 4–9 fold higher compared with the general population. The mortality rate of patients with cancer and VTE is more than 2-fold greater versus cancer patients without VTE. Given that the pathophysiology of thrombosis in cancer is multi-faceted, investigations of the mechanisms that regulate cancer-associated thrombosis (CAT) could improve the understanding and treatment of CAT. These mechanisms include activation of the coagulation and fibrinolytic systems. Tumor cells activate coagulation by expressing procoagulant molecules, releasing pro-inflammatory and pro-angiogenic cytokines, and adhering to vascular and blood cells. Tumor-secreted and tissue factor-positive extracellular vesicles are another major driver of CAT, while emerging studies have discovered a role for podoplanin (PDPN) in intratumoral thrombosis, hyper-coagulation, and enhanced VTE risk. In this article, we will review studies of PDPN in CAT, which together suggest that PDPN contributes not only to cancer progression and metastasis, but also to CAT. PDPN may therefore represent an attractive putative target for therapies that aim to simultaneously reduce cancer progression and associated VTE.

Abstrak – Apakah Pelaporan Terintegrasi Membawa Berkah ketika Covid-19? Tujuan Utama – Penelitian ini bertujuan menguji reaksi pelaporan terintegrasi ketika Covid-19. Metode – Penelitian ini menggunakan analisis regresi berganda. Sampel penelitian ini adalah perusahaan sektor kesehatan yang terdaftar di BEI selama tahun 2020-2021. Temuan Utama – Hasil pengujian menunjukkan sebagian besar perusahaan sektor kesehatan hanya melaporakan pengungkapan umum saja dari empat unsur pelaporan terintegrasi. Pengungkapan yang tidak banyak dilaporkan terkait dengan ekonomi, lingkungan, dan sosial. Implikasinya, pelaporan keuangan terintegrasi belum bisa menjadi berkah atau tidak menunjukkan reaksi yang berarti ketika Covid-19. Implikasi Teori dan Kebijakan – Penelitian ini menunjukkan teori agensi juga terjadi dalam perusahaan sektor kesehatan. Selain itu, penelitian ini juga merekomendasikan pembenahan dalam mekanisme pelaporan keuangan terintegrasi. Kebaruan Penelitian – Penelitian ini memfokuskan relevansi pelaporan terintegrasi pada saat kondisi Covid-19 khususnya sektor kesehatan. Abstract – Does Integrated Reporting Bring Blessings during Covid-19? Main Purpose – This research tests the reaction to integrated reporting during Covid-19. Method – This research uses multiple regression analysis. The sample for this research is healthcare sector companies listed on the IDX during 2020-2021. Main Findings – The test results show that most health sector companies only report general disclosures of the four elements of integrated reporting. Less reported disclosures relate to the economy, environment, and society. The implication is that integrated reporting cannot be a blessing or does not show a meaningful reaction during Covid-19. Theory and Practical Implications – This research shows agency theory also occurs in health sector companies. Apart from that, this research also recommends improvements to the integrated reporting mechanism. Novelty - This research focuses on the relevance of integrated reporting during Covid-19, especially in the healthcare sector.

Background: The Unani formulation Majun Brahmi (MB), a combination of herbs, is used in India as a brain tonic and memory enhancer. Aluminium deposition in the brain is associated with the development of neurodegenerative diseases. Aims and Objectives: The present study was designed to observe that the effects of MB have been evaluated on aluminium trichloride or aluminium chloride (AlCl3)-induced cognitive impairment in an experimental rat model. Materials and Methods: Twenty male Wistar albino rats were divided into four groups of five rats each. AlCl3 was administered orally for 30 days to induce cognitive impairment. Group I received saline, Group II-AlCl3 (100 mg/kg b.wt), Group III-MB (1027.77 mg/kg b.wt), and Group IV-AlCl3 + MB (100 mg/kg b.wt+1027.77 mg/kg b.wt). At the end of the experiment, rats were subjected to behavioral and biochemical assessments. Results: Animals treated with AlCl3 showed a significant increase in time to reach the platform in the Morris water maze test (MWM), prolonged transfer latency (TL) in the elevated plus maze, and decreased step-down latency in the passive avoidance test, as compared to controls (P

Senescence is a complicated, multi-factorial, irreversible cell cycle halt that has a tumor-suppressing effect in addition to being a significant factor in aging and neurological diseases. Damaged DNA, neuroinflammation, oxidative stress and disrupted proteostasis are a few of the factors that cause senescence. Senescence is triggered by DNA damage which initiates DNA damage response. The DNA damage response, which includes the formation of DNA damage foci containing activated H2AX, which is a key factor in cellular senescence, is provoked by a double strand DNA break. Oxidative stress impairs cognition, inhibits neurogenesis, and has an accelerated aging effect. Senescent cells generate pro-inflammatory mediators known as senescence-associated secretory phenotype (SASP). These pro-inflammatory cytokines and chemokines have an impact on neuroinflammation, neuronal death, and cell proliferation. While it is tempting to think of neurodegenerative diseases as manifestations of accelerated aging and senescence, this review will present information on brain ageing and neurodegeneration as a result of senescence and DNA damage response.

BackgroundChatbots have the potential to increase people’s access to quality health care. However, the implementation of chatbot technology in the health care system is unclear due to the scarce analysis of publications on the adoption of chatbot in health and medical settings. ObjectiveThis paper presents a protocol of a bibliometric analysis aimed at offering the public insights into the current state and emerging trends in research related to the use of chatbot technology for promoting health. MethodsIn this bibliometric analysis, we will select published papers from the databases of CINAHL, IEEE Xplore, PubMed, Scopus, and Web of Science that pertain to chatbot technology and its applications in health care. Our search strategy includes keywords such as “chatbot,” “virtual agent,” “virtual assistant,” “conversational agent,” “conversational AI,” “interactive agent,” “health,” and “healthcare.” Five researchers who are AI engineers and clinicians will independently review the titles and abstracts of selected papers to determine their eligibility for a full-text review. The corresponding author (ZN) will serve as a mediator to address any discrepancies and disputes among the 5 reviewers. Our analysis will encompass various publication patterns of chatbot research, including the number of annual publications, their geographic or institutional distribution, and the number of annual grants supporting chatbot research, and further summarize the methodologies used in the development of health-related chatbots, along with their features and applications in health care settings. Software tool VOSViewer (version 1.6.19; Leiden University) will be used to construct and visualize bibliometric networks. ResultsThe preparation for the bibliometric analysis began on December 3, 2021, when the research team started the process of familiarizing themselves with the software tools that may be used in this analysis, VOSViewer and CiteSpace, during which they consulted 3 librarians at the Yale University regarding search terms and tentative results. Tentative searches on the aforementioned databases yielded a total of 2340 papers. The official search phase started on July 27, 2023. Our goal is to complete the screening of papers and the analysis by February 15, 2024. ConclusionsArtificial intelligence chatbots, such as ChatGPT (OpenAI Inc), have sparked numerous discussions within the health care industry regarding their impact on human health. Chatbot technology holds substantial promise for advancing health care systems worldwide. However, developing a sophisticated chatbot capable of precise interaction with health care consumers, delivering personalized care, and providing accurate health-related information and knowledge remain considerable challenges. This bibliometric analysis seeks to fill the knowledge gap in the existing literature on health-related chatbots, entailing their applications, the software used in their development, and their preferred functionalities among users. International Registered Report Identifier (IRRID)PRR1-10.2196/54349

The current study aimed to investigate the effect of using a community-based learning approach (CBL) on the educational achievement of science students with different learning styles compared to the usual way of learning. The study sample consisted of 58 students studying science at An-Najah National University, students were studying different science strategies based on social interaction in the science teaching methods course. The study used an experimental approach with a semi-experimental design, and to achieve the objectives of the study, four achievement tests were prepared, and the modified Kolb test was used for the learning style. The results of a one-way ANOVA showed that there was a statistically significant difference between the mean scores of students on the educational achievement test in favour of the experimental group, while there was no difference due to the interaction between the method used in teaching and the learning style. In light of these results, the study recommended the use of the educational method (CBL) in teaching the course of methods of teaching science because of its role in raising the scientific achievement of students, its compatibility with different learning styles towards using it in learning, and the importance of training science students in preparing and qualifying them on how to use this strategy. The study also recommended conducting other studies in other educational subjects and stages of science and studying other variables in addition to the variables that the study dealt with.

ObjectiveThis study aims to examine the impact of e-WOM on customer purchase intentions in Facebook fan pages using theories of trust, value co-creation and brand attitude. The present research has set out to explore this emerging domain of study and has thus developed & tested propositions which attempt to establish a relationship between e-WOM and customer's purchase intentions. A deeper understanding of this possible association is obtained by studying the mediating roles of Trust, Value Co-Creation, Brand Image and Brand Attitude.MethodologyThe context for exploring this phenomenon is chosen to be the fan pages of smartphone brands on Facebook. The study involved conducting a sample survey of 490 respondents, comprising of both male and female, who belong to 5 smartphone brands Facebook fan pages-Samsung, Moto G, Lenovo, MI and ASUS are considered for the study. Out of which sample of 100 each has been targeted individually.FindingsThe findings suggested that e-WOM significantly predicts the purchase intentions of the customers of a specific product and considerable impacted on the purchase decision. The findings of the study also reveal that customer 's trust beliefs, perceived value co-creation, brand image and brand attitude partially mediate in between relationships of e-WOM and purchase intention.ConclusionThe actual presence of different types of consumer electronics brands on the social media, more prominently, the smartphones, which undoubtedly are the most ubiquitous product of this segment. In fact, this indicates that presence on social media is a well- thought organizational strategy developed by companies to gain partial control over the customer 's decision- making process by establishing a close connect with the customers for a long period.ImplicationThis consequence will significantly impact the decision-making process of marketers or practitioners in relation to their marketing tactics. This research also indicates that marketers could devise more effective methods for distributing marketing content through social networking sites, while corporations can cultivate favorable electronic word-of-mouth for their products or services. Through the implementation of social media marketing strategies, companies can increase their sales volume and generate higher revenue. The study examined the role of trust, virtual community participation, and desire to purchase as mediators on smartphone brand fan sites on Facebook. It was observed that these factors had a partial influence on customer purchase intention.

The rise of fine particulate matter (PM2.5) levels in urban areas, driven by traffic, construction, and combustion emissions, has prompted urgent air quality concerns. Understanding source-specific PM2.5 chemical characteristics and developing associated source markers is essential for knowing their accurate contribution to atmospheric PM2.5. This study focuses on developing PM2.5 chemical source profiles from nine different emissions, primarily categorized under traffic and combustion sources. The chemical characterization included the carbonaceous thermal fractions, inorganic ions, and elemental composition. Heterogeneity in chemical composition across emission sources was examined using the coefficient of divergence and diagnostic ratio, and finally, source-specific chemical fingerprints were developed using the ratio normalization approach. The finding revealed significant inter and intra-variation in the chemical composition among traffic and combustion emission sources. Organic matter is observed significantly higher in combustion sources (84%–92%) than in traffic sources (22%–45%). Both OC/EC and char-EC/soot-EC values showed much higher values for combustion sources than traffic emissions, with cow dung cake burning emissions displaying the largest values. Also, char-EC/soot-EC values showed a similar trend with OC/EC values and thus can be used as an additional marker for deciphering emission sources. The ion-balance ratio revealed particle emissions from coal, cow dung, and garbage burning to be highly acidic, while traffic and construction sources were alkaline. Source marker results provide new insights into differences in the chemical fingerprint of specific emission sources. A new set of source markers was seen for garbage burning while coal-burning emissions showed varying chemical fingerprints and were found to be dependent on coal processing. Among elements, bromine and chlorine are found to be the unique markers for cow dung cake-burning emissions. Receptor models can use the database developed from the current work to demarcate the emission sources accurately and benefit the regulatory bodies in developing efficient control measures.

Abstract This paper presents a simple method for detecting both biotic and abiotic stress in plants. Stress levels are measured based on the increase in nutrient uptake by plants as a mechanism of self-defense when under stress. A continuous electrical resistance measurement was used to estimate the rate of change of nutrients in agarose as the growth medium for Cicer arietinum (Chickpea) seeds. To determine the concentration of charge carriers in the growth medium, Drude’s model was used. For identifying anomalies and forecasting plant stress, two experiments were conducted and outliers were found in electrical resistance and relative changes in carrier concentration. Anomaly in the first iteration was detected by applying k-Nearest Neighbour, One Class Support Vector Machine and Local Outlier Factor in unsupervised mode on electrical resistance data. In the second iteration, the neural network-based Long Short Term Memory method was used on the relative change in the carrier concentration data. As a result of the change in resistance of growth media during stress, nutrient concentrations shifted by 35%, as previously reported. Farmers who cater to small communities around them and are most affected by local and global stress factors can use this method of forecasting.

Background: Present study was performed to assess the biologic width relocation by performing aesthetic crown lengthening with the help of Chu aesthetic gauges. Methods: The study included 192 teeth from 17 individuals, of which 64 teeth underwent crown lengthening (Treated site- TS) and 128 of which shared a proximal surface (Adjacent site –AS, Non-Adjacent site- NAS) with the surgery site. The clinical parameters Plaque index (PI), gingival index (GI), gingival margin position (PGM), relative attachment level (RAL), bone sounding (BS), biological width (BW), and probing depth (PD) were recorded. The clinical recordings were made at three different times: at baseline, 3 and 6 months post-operatively. Statistical analysis was performed using one way ANOVA and for pair wise comparisons post hoc Tukey test was used. Data was expressed in mean and standard deviations. P 0.05) was recorded at 3–6 months comparison for PGM, RAL, BS, BW and PD. Conclusion: Present study concluded that usage of Chu Aesthetic gauges help in controlled removal of soft and hard tissues, biologic width and gingival margin position got stabilized within 3 months and final prosthesis can be advised after 3 months of surgery.

Introduction. In order to realize an efficient speed control of induction motor, speed sensors, such as encoder, resolver or tachometer may be utilized. However, some problems appear such as, need of shaft extension, which decreases the mechanical robustness of the drive, reduce the reliability, and increase in cost. Purpose. In order to eliminate of speed sensors without losing. Several solutions to solve this problem have been suggested. Based on the motor fundamental excitation model, high frequency signal injection methods. The necessity of external hardware for signal injection and the adverse influence of injecting signal on the motor performance do not constitute an advantage for this technique. Fundamental model-based strategies method using instantaneous values of stator voltages and currents to estimate the rotor speed has been investigate. Several other methods have been proposed, such as model reference adaptive system, sliding mode observers, Luenberger observer and Kalman filter. The novelty of the proposed work consists in presenting a model reference adaptive system based speed estimator for sensorless direct torque control modified for induction motor drive. The model reference adaptive system is formed with flux rotor and the estimated stator current vector. Methods. The reference model utilizes measured current vector. On the other hand, the adjustable model uses the estimated stator current vector. The current is estimated through the solution of machine state equations. Practical value. The merits of the proposed estimator are demonstrated experimentally through a test-rig realized via the dSPACE DS1104 card in various operating conditions. The experimental results show the efficiency of the proposed speed estimation technique. Experimental results show the effectiveness of the proposed speed estimation method at nominal speed regions and speed reversal, and good results with respect to measurement speed estimation errors obtained.

Abstract This paper presents the evaluation of air quality in different districts of Haryana. Geo-spatial techniques were used to estimate gaseous and particulate pollutant's spatial and temporal variation during complete nationwide lockdown period and same month of previous year 2019 (March to May). Data of six fixed pollutants were collected from Central Pollution Control Board (CPCB). In this context, the data of air pollutants (PM10, PM2.5, O3, NOx, SO2, and CO) were analyzed for 2019 and 2020. The Spatio-temporal distribution of the Air Quality Index (AQI) clearly depicts difference in lockdown and unlock period. The result was showed that the air quality was very poor to satisfactory in 2019 and an improvement was observed from satisfactory to good in 2020 due to COVID-19 lockdown. On the basis of result, it will be concluded that automobile and industry are the major contributor in increase the pollutant concentration.

BackgroundChemsex—the use of psychoactive drugs to enhance the sexual experience—is an increasing phenomenon globally. Despite the increasing burden and associated harms of chemsex, evidence-based interventions (ie, behavioral and pharmacological) for chemsex users are nonexistent. ObjectiveIn this study, we assessed the usability and acceptability of a mobile health (mHealth)–delivered safer chemsex package (“PartyPack”) as a sexual harm reduction strategy among men who have sex with men in Malaysia—a setting where chemsex is becoming increasingly prevalent. MethodsThis study is part of a larger smartphone app-based intervention (ie, JomPrEP; University of Connecticut) designed to improve access to HIV prevention services among Malaysian men who have sex with men. A total of 50 participants were recruited from the Greater Kuala Lumpur region of Malaysia to use the JomPrEP app, which included a feature allowing participants to order PartyPack, for 30 days (March-April 2022). The usability and acceptability of the PartyPack were assessed using self-report, app analytics, and exit interviews (n=20). ResultsOverall, 8% (4/50) of participants reported having engaged in chemsex in the past 6 months; however, engagement in condomless sex (34/50, 68%) and group sex (9/50, 18%) was much higher. A total of 43 (86%) participants ordered PartyPack, of which 27 (63%) made multiple orders during the 30 days. Most participants (41/43, 95%) reported being satisfied with the PartyPack order feature in the app, with 91% (39/43) indicating the order and tracking process was easy. Thematic data exploration further revealed important information for understanding (eg, items included in the package, use of mHealth platform to order package, and discreetness of the PartyPack box and order and delivery) and refining the logistical preferences (eg, using branded items and allowing customization during order). ConclusionsOur findings provide strong evidence of the usability and acceptability of a mHealth-delivered safer chemsex package as a potential sexual harm reduction tool among this underserved population. Replication in a study with a larger sample size to test the efficacy of the PartyPack is warranted.

MicroRNAs (miRNAs) are single-stranded RNA molecules of 18-27 nucleotides that regulate gene expression after transcription. The great stability of detectable miRNAs in tissue, blood, and other body fluids provides a rich supply of miRNA-based biomarkers in human malignancies. miRNA dysregulation has been linked to cancer often, especially since they are commonly involved in mechanisms such as transcriptional control, epigenetic regulation and genomic instabilities. Despite the fact that a growing number of potential miRNA biomarkers have been identified, the translation of miRNA-based biomarkers from bench to bedside still faces a number of obstacles. miR-96 is encoded by conserved & paralogous miR-183/-96/-182 cluster that is widely studied in cancer. miR-96 is one of the most important miRNAs that is fast emerging as a novel biomarker with great potential as a diagnostic and therapeutic target in all types of cancers of the body. miR-96 plays a direct or indirect role as an oncogene in various cancers. miR-96 was believed to suppress Epithelial-mesenchymal transition, Osteosarcoma, Gastric adenocarcinoma and Bladder cancer. The miR-96 is also considered to have the function to promote malignancy as well as chemoresistance in Breast cancer. We present the most recent research findings on miR-96's clinicopathological relevance, development, and progress in this review, highlighting its oncogenic and tumor suppressive capabilities and an intermediate role in progressing the development of cancer, being a part of some cancer promoting pathways.

This research employs advanced numerical analysis using the Coupled Eulerian-Lagrangian Finite-Element method to evaluate the blast resistance of an underground steel pipeline subjected to surface and subsurface detonations. A pipeline model, reflecting standard gas and oil infrastructure, was created in Abaqus with a 1-meter external diameter, 10-millimeter wall thickness, and 12-meter length, buried 2 meters deep in brown clayey soil. The study applies various constitutive models, including Simplified Johnson-Cook Plasticity for the pipeline, Jones-Wilkins-Lee EOS for TNT, ideal gas EOS for air, and Mohr-Coulomb Plasticity for the soil. Results reveal that subsurface explosions severely compromise the pipeline's structural integrity, causing concentrated stress and displacement, while surface explosions produce broader, less severe effects. The study highlights the need for further research on the impact of water on pipeline resilience in different environments.

Objectives: The American Joint Committee on Cancer (AJCC) proposed staging system in order to stratify patients with oral cancer. The tumor-nodal-metastasis (TNM) classification is widely used to plan treatment and to estimate the prognosis of patients. The 8th edition staging system incorporated two major prognostic factors; depth of invasion (DOI) and extra-nodal extension (ENE). This study was done to evaluate and assess the difference in staging of AJCC 8th edition oral squamous cancer carcinoma (OSCC) when compared with AJCC 7th edition and to understand the pattern of stage migration due to these modifications. Materials and methods: Patients operated for OSCC with histopathology reports staged according to AJCC 8th edition were included in this single center, retrospective study between 2019 and 2022. Results: Out of total 200 patients, 9 cases were upstaged on the basis of DOI. 2 cases underwent stage migration from stage I to stage II, 4 cases from stage II to stage III, 2 cases from stage III to IV and 1 case underwent stage migration from II to IV. Likewise, 31 cases were upstaged on the basis of ENE and underwent upstaging from stage IVa to stage IVb. Conclusion: The AJCC 8th edition upstaged a total of 31% of patients with oral cavity cancers. 4.5% cases were upstaged on the basis of DOI. 26.5% patients were upstaged on the basis of presence of ENE. To conclude, the new classification has enabled us to adequately manage patients who were previously under-staged and under-treated.

Background: Oral cancer treatment consists of surgical resection, neck dissection and reconstruction. Postoperative complications influence overall surgical outcome, increase costs and hospital stay. Methods: A cohort study of 140 patients operated for oral cavity cancer, was undertaken. Patients were evaluated for 7 complications within the 30 day postoperative period. Complications included wound dehiscence, wound infection, partial flap loss, total flap loss, orocutaneous, wound bleeding and chyle leak. Results: Overall complication rate was 45% [n ​= ​63]. Most noted complication was wound dehiscence [30.71%]. Risk factors assessed were age, sex, stage of the lesion and flap used. Staging of the disease and reconstruction flap used were found to have statistically significant association with incidence of complications [p value ​

Majority of non-Hodgkin lymphoma (NHL) patients who achieve partial response (PR) or stable disease (SD) to CAR T-cell therapy (CAR T) on day +30 progress and only 30% achieve spontaneous complete response (CR). This study is the first to evaluate the role of consolidative radiotherapy (cRT) for residual fluorodeoxyglucose (FDG) activity on day +30 post- CAR T in NHL. We retrospectively reviewed 61 patients with NHL who received CAR T and achieved PR or SD on day +30. Progression-free survival (PFS), overall survival (OS), and local relapse-free survival (LRFS) were assessed from CAR T infusion. cRT was defined as comprehensive - treated all FDG-avid sites - or focal. Following day +30 positron emission tomography scan, 45 patients were observed and 16 received cRT. Fifteen (33%) observed patients achieved spontaneous CR, and 27 (60%) progressed with all relapses involving initial sites of residual FDG activity. Ten (63%) cRT patients achieved CR, and four (25%) progressed with no relapses in the irradiated sites. The 2-year LRFS was 100% in the cRT sites and 31% in the observed sites (P

Background: Rheumatoid arthritis (RA) is a chronic and systemic autoimmune disease that is characterized by severe synovial inflammation, cartilage erosion, bone loss, and generalized vasculopathy. Although the immunologic mechanism of RA is still unclear, it is now thought to be a primarily Th17-driven disease. Along with other factors, IL-23 stimulates the expansion of Th17 cells from naive CD4+ T cells. Objective: The objective of this study is to assess the circulating levels of interleukin (IL)-23 in rheumatoid arthritis (RA) and determine the correlation between plasma/serum IL-23 levels and disease activity. So, we performed a systematic review with meta-analysis comparing plasma/serum IL-23 levels between patients with RA and controls and examined correlation coefficients between circulating IL-23 levels and disease activity Subjects and Methods: Using the following keywords: lenterleukin-23, IL-23, and rheumatoid arthritis, a comprehensive literature search was carried out in the following databases: PubMed, Scopus, Google Scholar, and Web of Science. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses standards were followed, and the review was registered in the PROSPERO International prospective register of systematic reviews with registration number CRD42022345901. Results were reported as standardized mean differences (SMDs) with a 95% confidence interval. All statistical analysis was performed using StatsDirect statistical software version 3.0.0 (StatsDirect Ltd., Cheshire, UK). A sensitivity analysis was conducted using the leave-one-out approach to test the robustness of the results. Results: The total sample size for the RA group included in our review was 408 cases, while the control group sample size was 244 cases. The serum IL-23 level in the RA group was significantly higher than the control group (pooled SMD = 3.5, 95% CI; 2.1: 4.8, P < 0.0001) as compared to the control group. There were 8 studies with a total sample size of 402 that reported the correlation between IL-23 and DAS28-based RA activity. According to our findings, a significantly positive correlation between IL-23 and DAS28-based RA activity was found, with a weighted mean correlation of 0.57 (95% CI; 0.4: 0.75, P < 0.0001). Conclusion: Our meta-analysis has shown that IL-23 circulatory levels are higher in RA patients and that there is a significant positive correlation between IL-23 and disease activity. Our findings emphasize the role that IL-23 may have in RA. More studies may be required to fully comprehend the involvement of IL-23 in RA.

This study aims to analyze and explain the effect of competitive advantage (cost of capital, capital intensity, advertising expenses), profitability (ROA, ROE, NPM), dividend policy (DPR, DPS, Yield) on firm value (MBR, MBA, Tobin’s Q). The researcher uses explanatory research with a quantitative approach and the object of the research uses the company IDX LQ45 which is listed on the Indonesia Stock Exchange in 2015-2020. The total sample in this study was 4 companies from a population of 45 companies that met the sampling criteria and this study uses Partial Least Squares (PLS) as research data management. The results show that the effect of competitive advantage has a significant effect on profitability, profitability has no significant effect on firm value, competitive advantage has a significant effect on dividend policy, dividend policy has no significant effect on firm value and competitive advantage has a significant effect on firm value

Background: Nonmedical use of prescription drugs for recreational purposes is a major health problem that raises high concerns for public health. Recently, several laboratory studies have reported the misuse of pentazocine, an agonist-antagonist opioid in combination with antihistamines in opioid addicts. Illicit self administration of prescription drugs has been increasingly reported in India. Urinalysis as an adjunct to self report plays a key role in providing additional information in the treatment of drug users. This paper aims to discuss a simple, convenient, and rapid capillary column gas-liquid chromatography method for simultaneous detection of pentazocine, pheniramine, and cotinine in urine.Methods: The sample was extracted with chloroform and isopropanol (3:1,v/v) and evaporated to dryness. After reconstitution with methanol, it was directly subjected to gas chromatography analysis. Method performance was evaluated and validated in terms of sensitivity, precision, the limit of detection (LOD), and the limit of quantification (LOQ).Findings: The linearity obtained was in the range of 50–1000 ng/ml with a correlation coefficient (r) above 0.999 for each drug. Good LOQ (50ng/ml) was obtained with each drug. Also, the developed method was effective in analyzing samples from patients with suspected abuse of these drugs.Conclusion: The technique was found to be simple, robust, sensitive, and precise in the simultaneous analysis of drugs (pentazocine, pheniramine, and cotinine). This method was proved to be useful and cost-effective in treating and monitoring patients seeking help for addiction in clinical settings.

Purpose: Compare overall survival (OS) and breast cancer-specific survival (BCSS) outcomes of breast conservative therapy (BCT) and mastectomy in a large cohort of patients with early-stage triple negative breast cancer (TNBC), using a propensity score-based matching approach. Methods: Surveillance, Epidemiology, and End Results (SEER) database was used to study the role of RT in early stage TNBC. Primary end points were OS and BCSS. Cox proportional hazard regression models and Kaplan-Meier plots were used to generate the desired outcomes. Propensity score matching was done to minimize bias. Results: 12,761 patients with T1-2N0M0 TNBC as their first malignancy were retrieved. Of these 7237 had lumpectomy with RT, and 5524 had mastectomy only. Age, race, marital status, tumor laterality, grade and stage, and receipt of chemotherapy were prognostic variables for OS and BCSS. Among 4848 matched subjects, the 5-year OS was significantly higher in patients with lumpectomy and RT (89%) compared to mastectomy alone (84.5%) (p-value

Risedronate sodium (RIS) exhibits limited bioavailability and undesirable gastrointestinal effects when administered orally, necessitating the development of an alternative formulation. In this study, mPEG-coated nanoparticles loaded with RIS-HA-TCS were created for osteoporosis treatment. Thiolated chitosan (TCS) was synthesized using chitosan and characterized using DSC and FTIR, with thiol immobilization assessed using Ellman’s reagent. RIS-HA nanoparticles were fabricated and conjugated with synthesized TCS. Fifteen batches of RIS-HA-TCS nanoparticles were designed using the Box–Behnken design process. The nanoparticles were formulated through the ionic gelation procedure, employing tripolyphosphate (TPP) as a crosslinking agent. In silico activity comparison of RIS and RIS-HA-TCS for farnesyl pyrophosphate synthetase enzyme demonstrated a higher binding affinity for RIS. The RIS-HA-TCS nanoparticles exhibited 85.4 ± 2.21% drug entrapment efficiency, a particle size of 252.1 ± 2.44 nm, and a polydispersity index of 0.2 ± 0.01. Further conjugation with mPEG resulted in a particle size of 264.9 ± 1.91 nm, a PDI of 0.120 ± 0.01, and an encapsulation efficiency of 91.1 ± 1.17%. TEM confirmed the spherical particle size of RIS-HA-TCS and RIS-HA-TCS-mPEG. In vitro release studies demonstrated significantly higher release for RIS-HS-TCS-mPEG (95.13 ± 4.64%) compared to RIS-HA-TCS (91.74 ± 5.13%), RIS suspension (56.12 ± 5.19%), and a marketed formulation (74.69 ± 3.98%). Ex vivo gut permeation studies revealed an apparent permeability of 0.5858 × 10−1 cm/min for RIS-HA-TCS-mPEG, surpassing RIS-HA-TCS (0.4011 × 10−4 cm/min), RIS suspension (0.2005 × 10−4 cm/min), and a marketed preparation (0.3401 × 10−4 cm/min).

Objectives: Nine strong cyclones have been recorded in Oman in the last 50 years, the last being tropical cyclone Shaheen in October 2021, in the northern Oman area. The aim of our study was to determine the relationship between property loss and the mental health of residents after cyclone Shaheen. Methods: We conducted a cross-sectional study among Omani citizens living in areas affected by cyclone Shaheen three to six months post-cyclone. In an online, self-reported questionnaire, we assessed the loss of participants’ properties due to the cyclone and the impact on their perceived mental health. Descriptive statistics, chi-square tests, and associations between demographics, loss of properties, and mental health were performed. Results: Of 440 participants, 79.3% had their houses directly damaged by the cyclone and 90.7% had their outside properties damaged. Most of the respondents reported that they suffered from mental health symptoms in the months following the cyclone. Women, people with a lower socioeconomic status, the unemployed, and those without a university degree were associated with poorer mental health outcomes. Mental health was significantly lower for respondents whose properties were mostly affected by the cyclone. Conclusions: With scant knowledge about how cyclones directly affect Omanis’ mental health, the results of this study are paramount for the planning of psychological care services to improve the country’s response to extreme weather events.