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309 results on '"Saffi, Jenifer"'

9. DNA damage response in patients with pediatric Acute Lymphoid Leukemia during induction therapy

Author

Portich, Júlia Plentz, dos Santos, Rafael Pereira, Kersting, Nathalia, Jorge, Karolina Brochado, Casagrande, Pietro Rebelo, dos Santos Costa, Gabriela, Dias Cionek, Jéssica Maria Gonçalves, Olguins, Danielly Brufatto, Sinigaglia, Marialva, Busatto, Franciele Faccio, Saffi, Jenifer, Maluf, Sharbel Weidner, Loss, Jiseh Fagundes, Brunetto, Algemir Lunardi, Roesler, Rafael, and de Farias, Caroline Brunetto

Published
2017
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15. High Expression of MRE11A Is Associated with Shorter Survival and a Higher Risk of Death in CRC Patients.

Author

Azambuja, Daniel de Barcellos, e Gloria, Helena de Castro, Montenegro, Gabriel e Silva, Kalil, Antonio Nocchi, Hoffmann, Jean-Sébastien, Leguisamo, Natalia Motta, and Saffi, Jenifer

Subjects
GENE expression, DOUBLE-strand DNA breaks, DNA repair, DEATH rate, PROGRESSION-free survival, NUCLEOTIDE sequence, COLORECTAL cancer
Abstract

Background: Homologous recombination repair (HR) is the most accurate repair pathway for double-strand breaks and replication fork disruption that is capable of faithfully restoring the original nucleotide sequence of the broken DNA. The deficiency of this mechanism is a frequent event in tumorigenesis. Therapies that exploit defects in HR have been explored essentially in breast, ovarian, pancreatic, and prostate cancers, but poorly in colorectal cancers (CRC), although CRC ranks second in mortality worldwide. Methods: Tumor specimens and matched healthy tissues from 63 patients with CRC were assessed for gene expression of key HR components and mismatch repair (MMR) status, which correlated with clinicopathological features, progression-free survival, and overall survival (OS). Results: Enhanced expression of MRE11 homolog (MRE11A), the gene encoding a key molecular actor for resection, is significantly overexpressed in CRC, is associated with the occurrence of primary tumors, particularly T3-T4, and is found in more than 90% of the right-side of CRC, the location with the worst prognosis. Importantly, we also found that high MRE11A transcript abundance is associated with 16.7 months shorter OS and a 3.5 higher risk of death. Conclusion: Monitoring of MRE11 expression could be used both as a predictor of outcome and as a marker to select CRC patients for treatments thus far adapted for HR-deficient cancers. [ABSTRACT FROM AUTHOR]

Published
2023
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17. Antioxidant and Anticancer Potential of the New Cu(II) Complexes Bearing Imine-Phenolate Ligands with Pendant Amine N-Donor Groups.

Author

Pinheiro, Adriana Castro, Nunes, Ianka Jacondino, Ferreira, Wesley Vieira, Tomasini, Paula Pellenz, Trindade, Cristiano, Martins, Carolina Cristóvão, Wilhelm, Ethel Antunes, Oliboni, Robson da Silva, Netz, Paulo Augusto, Stieler, Rafael, Casagrande Jr., Osvaldo de Lazaro, and Saffi, Jenifer

Subjects
COPPER, COPPER compounds, LIGANDS (Biochemistry), DENSITY functional theory, COLORECTAL cancer, DNA damage
Abstract

Cu(II) complexes bearing NNO-donor Schiff base ligands (2a, b) have been synthesized and characterized. The single crystal X-ray analysis of the 2a complex revealed that a mononuclear and a dinuclear complex co-crystallize in the solid state. The electronic structures of the complexes are optimized by Density Functional Theory (DFT) calculations. The monomeric nature of 2a and 2b species is maintained in solution. Antioxidant activities of the ligands (1a, b) and Cu(II) complexes (2a, b) were determined by in vitro assays such as 1,1-diphenyl-2-picrylhydrazyl free radicals (DPPH.) and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) radicals (ABTS+). Our results demonstrated that 2a showed better antioxidant activity. MTT assays were performed to assess the toxicity of ligands and Cu(II) complexes in V79 cells. The antiproliferative activity of compounds was tested against two human tumor cell lines: MCF-7 (breast adenocarcinoma) and SW620 (colorectal carcinoma) and on MRC-5 (normal lung fibroblast). All compounds showed high cytotoxicity in the all-cell lines but showed no selectivity for tumor cell lines. Antiproliferative activity by clonogenic assay 2b showed a more significant inhibitory effect on the MCF-7 cell lines than on MRC-5. DNA damage for the 2b compound at 10 µM concentration was about three times higher in MCF-7 cells than in MRC-5 cells. [ABSTRACT FROM AUTHOR]

Published
2023
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32. Evaluation of the cytotoxic and antimutagenic effects of biflorin, an antitumor 1,4 o-naphthoquinone isolated from Capraria biflora L

Author

Vasconcellos, Marne C., Moura, Dinara J., Rosa, Renato M., Machado, Miriana S., Guecheva, Temenouga N., Villela, Izabel, Immich, Bruna F., Montenegro, Raquel C., Fonseca, Aluísio M., Lemos, Telma L. G., Moraes, Maria Elisabete A., Saffi, Jenifer, Costa-Lotufo, Letícia V., Moraes, Manoel O., and Henriques, João A. P.

Published
2010
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40. Genotoxicity of 15-deoxygoyazensolide in bacteria and yeast

Author

Vasconcellos, Marne C., Rosa, Renato M., Machado, Miriana S., Villela, Izabel V., Crotti, Antônio Eduardo Miller, Lopes, João Luis Callegari, Pessoa, Cláudia, de Moraes, Manoel Odorico, Lopes, Norberto Peporine, Costa-Lotufo, Letícia V., Saffi, Jenifer, and Henriques, João Antônio Pegas

Published
2007
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