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4 results on '"S. V. Shorunov"'

1. Correction: Genotoxic effect of 2,2'-bis(bicyclo[2.2.1] heptane) on bacterial cells

Author

Ilya V. Manukhov, Maxim V. Bermeshev, V. O. Samoilov, V G Pevgov, A. Kessenikh, Lev S. Yaguzhinsky, A. L. Maksimov, Sergey V. Bazhenov, E. Gnuchikh, and S. V. Shorunov

Subjects
Heptane, chemistry.chemical_compound, Multidisciplinary, chemistry, Bicyclic molecule, Science, Medicine, Medicinal chemistry
Abstract

[This corrects the article DOI: 10.1371/journal.pone.0228525.].

Published
2021

2. Toxic effect of 2,2’-bis(bicyclo[2.2.1] heptane) on bacterial cells

Author

A. G. Kessenikh, Lev S. Yaguzhinsky, S. V. Bazhenov, Ilya V. Manukhov, E. Y. Gnuchikh, S. V. Shorunov, A. L. Maksimov, V. O. Samoilov, Maxim V. Bermeshev, and V G Pevgov

Subjects
chemistry.chemical_classification, Reactive oxygen species, Heptane, DNA damage, Superoxide, Oxidative phosphorylation, medicine.disease_cause, SOXS, chemistry.chemical_compound, Biochemistry, chemistry, Toxicity, medicine, bacteria, Escherichia coli
Abstract

Here we present the study of the genotoxic effect of a 2,2’-bis(bicyclo[2.2.1]heptane) (BBH), which is promising as a fuel component for liquid rocket engines. The use ofEscherichia coli lux-biosensors showed that in addition to DNA damage causing SOS-response, there is also an oxidative effect on cells. The greatest toxicity is determined by the mechanism of formation of superoxide anion radical and is detected by the lux biosensorE. colipSoxS-lux, in which the genes of bacterial luciferases are transcriptionally crosslinked with the promoter of thesoxSgene. It is assumed that the oxidation of BBH leads to the formation of reactive oxygen species, which should give the main contribution to the toxicity of this substance.

Published
2020
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3. Genotoxic effect of 2,2'-bis(bicyclo[2.2.1] heptane) on bacterial cells

Author

V. O. Samoilov, S. V. Shorunov, A. Kessenikh, A. L. Maksimov, E. Gnuchikh, Ilya V. Manukhov, Lev S. Yaguzhinsky, Sergey V. Bazhenov, Maxim V. Bermeshev, and V G Pevgov

Subjects
0301 basic medicine, Luminescence, Alkylation, Biosensing Techniques, medicine.disease_cause, 01 natural sciences, Biochemistry, Physical Chemistry, chemistry.chemical_compound, Superoxides, SOS response, chemistry.chemical_classification, Multidisciplinary, Superoxide, Physics, Electromagnetic Radiation, Chemical Reactions, Detectors, Oxides, Peroxides, Nucleic acids, Chemistry, Physical Sciences, Engineering and Technology, Medicine, Research Article, Anions, Stereochemistry, DNA damage, Science, Equipment, Oxidative phosphorylation, 010402 general chemistry, Regulon, 03 medical and health sciences, Bridged Bicyclo Compounds, Oxidation, medicine, Genetics, Escherichia coli, Luciferase, Ions, Reactive oxygen species, Biology and life sciences, Dose-Response Relationship, Drug, Chemical Compounds, Correction, DNA, Hydrogen Peroxide, Hydrocarbons, 0104 chemical sciences, Oxidative Stress, 030104 developmental biology, Biosensors, chemistry, bacteria, Genotoxicity, DNA Damage, Mutagens
Abstract

The toxic effect of strained hydrocarbon 2,2'-bis (bicyclo[2.2.1]heptane) (BBH) was studied using whole-cell bacterial lux-biosensors based on Escherichia coli cells in which luciferase genes are transcriptionally fused with stress-inducible promoters. It was shown that BBH has the genotoxic effect causing bacterial SOS response however no alkylating effect has been revealed. In addition to DNA damage, there is an oxidative effect causing the response of OxyR/S and SoxR/S regulons. The most sensitive to BBH lux-biosensor was E. coli pSoxS-lux which reacts to the appearance of superoxide anion radicals in the cell. It is assumed that the oxidation of BBH leads to the generation of reactive oxygen species, which provide the main contribution to the genotoxicity of this substance.

Published
2020

4. Synthesis of 3,4-bis(2,5-dimethyl-3-thienyl)furan-2,5-dione from mucobromic acid.

Author

S. V. Shorunov, F. M. Stoyanovich, and M. M. Krayushkin

Abstract

Abstract Palladium-catalyzed cross-coupling between 2,5-dimethyl-3-thienylboronic and mucobromic acids under phase transfer catalysis (PTC) conditions gave the expected 3,4-bis(2,5-dimethyl-3-thienyl)-5-hydroxyfuran-2-one in 32% yield. The by-product was 2,2’,5,5’-tetramethyl-3,3’-bithiophene. The oxidation of the obtained hemiacylal with potassium permanganate under PTC conditions afforded 3,4-bis(2,5-dimethyl-3-thienyl)furan-2,5-dione in high yield. [ABSTRACT FROM AUTHOR]

Published
2004

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