1. Neither an intronic CA repeat within the CD48 gene nor the HERV-K18 polymorphisms are associated with type 1 diabetes.
- Author
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Ramos-Lopez E, Ghebru S, Van Autreve J, Aminkeng F, Herwig J, Seifried E, Seidl C, Van der Auwera B, and Badenhoop K
- Subjects
- CD48 Antigen, Case-Control Studies, Child, Child, Preschool, Dinucleotide Repeats, Female, Genetic Predisposition to Disease, Genotype, Humans, Introns genetics, Linkage Disequilibrium, Male, Polymorphism, Genetic, Software, Antigens, CD genetics, Diabetes Mellitus, Type 1 genetics, Endogenous Retroviruses genetics, Membrane Proteins genetics, Superantigens genetics
- Abstract
Type 1 diabetes is an autoimmune heterogeneous disease that is determined by environmental and genetic factors. A possible retroviral etiology has been inferred from the observation that human endogenous retrovirus (HERV)-K18 encoding a superantigen (SAg) has a polymorphism associated with this disease. Type 1 diabetes families from Germany and Belgium were genotyped for the novel HERV-8914 (303 families) and for the known HERV-8594 (284 families) polymorphisms within the SAg-coding region on the HERV-K18. Case-control analysis was performed for the HERV-8914 polymorphism (506 patients) and for the HERV-8594 polymorphism (370 patients) and compared with 350 German controls. Haplotypes were constructed. Additionally, a microsatellite within the CD48 gene was analyzed in German type 1 diabetes families (n=125) as well as in patients (n=375) and in healthy controls (n=350). No association was found for HERV-K18 polymorphisms or the CA repeat within the CD48 gene with type 1 diabetes mellitus either in families or by comparing patients and controls. In conclusion, we cannot confirm a role of HERV-K18 polymorphisms -HERV-8914 and HERV-8594- or of the CD48 CA repeat for type 1 diabetes susceptibility.
- Published
- 2006
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