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31 results on '"S, Chance"'

1. A framework for rigorous evaluation of human performance in human and machine learning comparison studies

Author

Hannah P. Cowley, Mandy Natter, Karla Gray-Roncal, Rebecca E. Rhodes, Erik C. Johnson, Nathan Drenkow, Timothy M. Shead, Frances S. Chance, Brock Wester, and William Gray-Roncal

Subjects
Medicine, Science
Abstract

Abstract Rigorous comparisons of human and machine learning algorithm performance on the same task help to support accurate claims about algorithm success rates and advances understanding of their performance relative to that of human performers. In turn, these comparisons are critical for supporting advances in artificial intelligence. However, the machine learning community has lacked a standardized, consensus framework for performing the evaluations of human performance necessary for comparison. We demonstrate common pitfalls in a designing the human performance evaluation and propose a framework for the evaluation of human performance, illustrating guiding principles for a successful comparison. These principles are first, to design the human evaluation with an understanding of the differences between human and algorithm cognition; second, to match trials between human participants and the algorithm evaluation, and third, to employ best practices for psychology research studies, such as the collection and analysis of supplementary and subjective data and adhering to ethical review protocols. We demonstrate our framework’s utility for designing a study to evaluate human performance on a one-shot learning task. Adoption of this common framework may provide a standard approach to evaluate algorithm performance and aid in the reproducibility of comparisons between human and machine learning algorithm performance.

Published
2022
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2. Random error propagation on electron beam dynamics for a 50 MeV S-band linac

Author

H Purwar, E Goutierre, H Guler, M Rossetti Conti, S Chance, A Gonnin, H Monard, A Bacci, M Sebag, J Cohen, and C Bruni

Subjects
electron beam dynamics, random error propagation, photoinjector, Science, Physics, QC1-999
Abstract

The stability and the quality of particle beams are of utmost importance for many emerging linac installations. The impact on beam properties damage of beam electromagnetic element misalignments and jitter/fluctuations in various accelerator sub-systems should be properly known, as usually such shot-to-shot fluctuations cannot be avoided. On top of that, knowing which parameters the machine is most sensitive to is of utmost to take precautionary measures to reduce the beam degradation and thus improve beam stability and quality. This simulation work focuses on a 50 MeV S-band linear accelerator based on RF photoinjector electron source. The sensitivity of the beam parameters towards several errors has been studied collectively as well as individually for each accelerator element. While the emittance at the end of the linac is dominated by the laminar behavior in the accelerating section, the main emittance degradation comes mainly from orbit errors located at the linac entrance.

Published
2023
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4. FCC Physics Opportunities

Author

A. Abada, M. Abbrescia, S. S. AbdusSalam, I. Abdyukhanov, J. Abelleira Fernandez, A. Abramov, M. Aburaia, A. O. Acar, P. R. Adzic, P. Agrawal, J. A. Aguilar-Saavedra, J. J. Aguilera-Verdugo, M. Aiba, I. Aichinger, G. Aielli, A. Akay, A. Akhundov, H. Aksakal, J. L. Albacete, S. Albergo, A. Alekou, M. Aleksa, R. Aleksan, R. M. Alemany Fernandez, Y. Alexahin, R. G. Alía, S. Alioli, N. Alipour Tehrani, B. C. Allanach, P. P. Allport, M. Altınlı, W. Altmannshofer, G. Ambrosio, D. Amorim, O. Amstutz, L. Anderlini, A. Andreazza, M. Andreini, A. Andriatis, C. Andris, A. Andronic, M. Angelucci, F. Antinori, S. A. Antipov, M. Antonelli, M. Antonello, P. Antonioli, S. Antusch, F. Anulli, L. Apolinário, G. Apollinari, A. Apollonio, D. Appelö, R. B. Appleby, Ara. Apyan, Arm. Apyan, A. Arbey, A. Arbuzov, G. Arduini, V. Arı, S. Arias, N. Armesto, R. Arnaldi, S. A. Arsenyev, M. Arzeo, S. Asai, E. Aslanides, R. W. Aßmann, D. Astapovych, M. Atanasov, S. Atieh, D. Attié, B. Auchmann, A. Audurier, S. Aull, S. Aumon, S. Aune, F. Avino, G. Avrillaud, G. Aydın, A. Azatov, G. Azuelos, P. Azzi, O. Azzolini, P. Azzurri, N. Bacchetta, E. Bacchiocchi, H. Bachacou, Y. W. Baek, V. Baglin, Y. Bai, S. Baird, M. J. Baker, M. J. Baldwin, A. H. Ball, A. Ballarino, S. Banerjee, D. P. Barber, D. Barducci, P. Barjhoux, D. Barna, G. G. Barnaföldi, M. J. Barnes, A. Barr, J. Barranco García, J. Barreiro Guimarães da Costa, W. Bartmann, V. Baryshevsky, E. Barzi, S. A. Bass, A. Bastianin, B. Baudouy, F. Bauer, M. Bauer, T. Baumgartner, I. Bautista-Guzmán, C. Bayındır, F. Beaudette, F. Bedeschi, M. Béguin, I. Bellafont, L. Bellagamba, N. Bellegarde, E. Belli, E. Bellingeri, F. Bellini, G. Bellomo, S. Belomestnykh, G. Bencivenni, M. Benedikt, G. Bernardi, J. Bernardi, C. Bernet, J. M. Bernhardt, C. Bernini, C. Berriaud, A. Bertarelli, S. Bertolucci, M. I. Besana, M. Besançon, O. Beznosov, P. Bhat, C. Bhat, M. E. Biagini, J.-L. Biarrotte, A. Bibet Chevalier, E. R. Bielert, M. Biglietti, G. M. Bilei, B. Bilki, C. Biscari, F. Bishara, O. R. Blanco-García, F. R. Blánquez, F. Blekman, A. Blondel, J. Blümlein, T. Boccali, R. Boels, S. A. Bogacz, A. Bogomyagkov, O. Boine-Frankenheim, M. J. Boland, S. Bologna, O. Bolukbasi, M. Bomben, S. Bondarenko, M. Bonvini, E. Boos, B. Bordini, F. Bordry, G. Borghello, L. Borgonovi, S. Borowka, D. Bortoletto, D. Boscherini, M. Boscolo, S. Boselli, R. R. Bosley, F. Bossu, C. Botta, L. Bottura, R. Boughezal, D. Boutin, G. Bovone, I. Božović Jelisavc̆ić, A. Bozbey, C. Bozzi, D. Bozzini, V. Braccini, S. Braibant-Giacomelli, J. Bramante, P. Braun-Munzinger, J. A. Briffa, D. Britzger, S. J. Brodsky, J. J. Brooke, R. Bruce, P. Brückman De Renstrom, E. Bruna, O. Brüning, O. Brunner, K. Brunner, P. Bruzzone, X. Buffat, E. Bulyak, F. Burkart, H. Burkhardt, J.-P. Burnet, F. Butin, D. Buttazzo, A. Butterworth, M. Caccia, Y. Cai, B. Caiffi, V. Cairo, O. Cakir, R. Calaga, S. Calatroni, G. Calderini, G. Calderola, A. Caliskan, D. Calvet, M. Calviani, J. M. Camalich, P. Camarri, M. Campanelli, T. Camporesi, A. C. Canbay, A. Canepa, E. Cantergiani, D. Cantore-Cavalli, M. Capeans, R. Cardarelli, U. Cardella, A. Cardini, C. M. Carloni Calame, F. Carra, S. Carra, A. Carvalho, S. Casalbuoni, J. Casas, M. Cascella, P. Castelnovo, G. Castorina, G. Catalano, V. Cavasinni, E. Cazzato, E. Cennini, A. Cerri, F. Cerutti, J. Cervantes, I. Chaikovska, J. Chakrabortty, M. Chala, M. Chamizo-Llatas, H. Chanal, D. Chanal, S. Chance, A. Chancé, P. Charitos, J. Charles, T. K. Charles, S. Chattopadhyay, R. Chehab, S. V. Chekanov, N. Chen, A. Chernoded, V. Chetvertkova, L. Chevalier, G. Chiarelli, G. Chiarello, M. Chiesa, P. Chiggiato, J. T. Childers, A. Chmielińska, A. Cholakian, P. Chomaz, M. Chorowski, W. Chou, M. Chrzaszcz, E. Chyhyrynets, G. Cibinetto, A. K. Ciftci, R. Ciftci, R. Cimino, M. Ciuchini, P. J. Clark, Y. Coadou, M. Cobal, A. Coccaro, J. Cogan, E. Cogneras, F. Collamati, C. Colldelram, P. Collier, J. Collot, R. Contino, F. Conventi, C. T. A. Cook, L. Cooley, G. Corcella, A. S. Cornell, G. H. Corral, H. Correia-Rodrigues, F. Costanza, P. Costa Pinto, F. Couderc, J. Coupard, N. Craig, I. Crespo Garrido, A. Crivellin, J. F. Croteau, M. Crouch, E. Cruz Alaniz, B. Curé, J. Curti, D. Curtin, M. Czech, C. Dachauer, R. T. D’Agnolo, M. Daibo, A. Dainese, B. Dalena, A. Daljevec, W. Dallapiazza, L. D’Aloia Schwartzentruber, M. Dam, G. D’Ambrosio, S. P. Das, S. DasBakshi, W. da Silva, G. G. da Silveira, V. D’Auria, S. D’Auria, A. David, T. Davidek, A. Deandrea, J. de Blas, C. J. Debono, S. De Curtis, N. De Filippis, D. de Florian, S. Deghaye, S. J. de Jong, C. Del Bo, V. Del Duca, D. Delikaris, F. Deliot, A. Dell’Acqua, L. Delle Rose, M. Delmastro, E. De Lucia, M. Demarteau, D. Denegri, L. Deniau, D. Denisov, H. Denizli, A. Denner, D. d’Enterria, G. de Rijk, A. De Roeck, F. Derue, O. Deschamps, S. Descotes-Genon, P. S. B. Dev, J. B. de Vivie de Régie, R. K. Dewanjee, A. Di Ciaccio, A. Di Cicco, B. M. Dillon, B. Di Micco, P. Di Nezza, S. Di Vita, A. Doblhammer, A. Dominjon, M. D’Onofrio, F. Dordei, A. Drago, P. Draper, Z. Drasal, M. Drewes, L. Duarte, I. Dubovyk, P. Duda, A. Dudarev, L. Dudko, D. Duellmann, M. Dünser, T. du Pree, M. Durante, H. Duran Yildiz, S. Dutta, F. Duval, J. M. Duval, Ya. Dydyshka, B. Dziewit, S. Eisenhardt, M. Eisterer, T. Ekelof, D. El Khechen, S. A. Ellis, J. Ellis, J. A. Ellison, K. Elsener, M. Elsing, Y. Enari, C. Englert, H. Eriksson, K. J. Eskola, L. S. Esposito, O. Etisken, E. Etzion, P. Fabbricatore, A. Falkowski, A. Falou, J. Faltova, J. Fan, L. Fanò, A. Farilla, R. Farinelli, S. Farinon, D. A. Faroughy, S. D. Fartoukh, A. Faus-Golfe, W. J. Fawcett, G. Felici, L. Felsberger, C. Ferdeghini, A. M. Fernandez Navarro, A. Fernández-Téllez, J. Ferradas Troitino, G. Ferrara, R. Ferrari, L. Ferreira, P. Ferreira da Silva, G. Ferrera, F. Ferro, M. Fiascaris, S. Fiorendi, C. Fiorio, O. Fischer, E. Fischer, W. Flieger, M. Florio, D. Fonnesu, E. Fontanesi, N. Foppiani, K. Foraz, D. Forkel-Wirth, S. Forte, M. Fouaidy, D. Fournier, T. Fowler, J. Fox, P. Francavilla, R. Franceschini, S. Franchino, E. Franco, A. Freitas, B. Fuks, K. Furukawa, S. V. Furuseth, E. Gabrielli, A. Gaddi, M. Galanti, E. Gallo, S. Ganjour, Jia. Gao, Jie. Gao, V. Garcia Diaz, M. García Pérez, L. García Tabarés, C. Garion, M. V. Garzelli, I. Garzia, S. M. Gascon-Shotkin, G. Gaudio, P. Gay, S.-F. Ge, T. Gehrmann, M. H. Genest, R. Gerard, F. Gerigk, H. Gerwig, P. Giacomelli, S. Giagu, E. Gianfelice-Wendt, F. Gianotti, F. Giffoni, S. S. Gilardoni, M. Gil Costa, M. Giovannetti, M. Giovannozzi, P. Giubellino, G. F. Giudice, A. Giunta, L. K. Gladilin, S. Glukhov, J. Gluza, G. Gobbi, B. Goddard, F. Goertz, T. Golling, D. Gonçalves, V. P. Goncalves, R. Gonçalo, L. A. Gonzalez Gomez, S. Gorgi Zadeh, G. Gorine, E. Gorini, S. A. Gourlay, L. Gouskos, F. Grancagnolo, A. Grassellino, A. Grau, E. Graverini, H. M. Gray, Ma. Greco, Mi. Greco, J.-L. Grenard, O. Grimm, C. Grojean, V. A. Gromov, J. F. Grosse-Oetringhaus, A. Grudiev, K. Grzanka, J. Gu, D. Guadagnoli, V. Guidi, S. Guiducci, G. Guillermo Canton, Y. O. Günaydin, R. Gupta, R. S. Gupta, J. Gutierrez, J. Gutleber, C. Guyot, V. Guzey, C. Gwenlan, Ch. Haberstroh, B. Hacışahinoğlu, B. Haerer, K. Hahn, T. Hahn, A. Hammad, C. Han, M. Hance, A. Hannah, P. C. Harris, C. Hati, S. Haug, J. Hauptman, V. Haurylavets, H-J. He, A. Hegglin, B. Hegner, K. Heinemann, S. Heinemeyer, C. Helsens, Ana. Henriques, And. Henriques, P. Hernandez, R. J. Hernández-Pinto, J. Hernandez-Sanchez, T. Herzig, I. Hiekkanen, W. Hillert, T. Hoehn, M. Hofer, W. Höfle, F. Holdener, S. Holleis, B. Holzer, D. K. Hong, C. G. Honorato, S. C. Hopkins, J. Hrdinka, F. Hug, B. Humann, H. Humer, T. Hurth, A. Hutton, G. Iacobucci, N. Ibarrola, L. Iconomidou-Fayard, K. Ilyina-Brunner, J. Incandela, A. Infantino, V. Ippolito, M. Ishino, R. Islam, H. Ita, A. Ivanovs, S. Iwamoto, A. Iyer, S. Izquierdo Bermudez, S. Jadach, D. O. Jamin, P. Janot, P. Jarry, A. Jeff, P. Jenny, E. Jensen, M. Jensen, X. Jiang, J. M. Jiménez, M. A. Jones, O. R. Jones, J. M. Jowett, S. Jung, W. Kaabi, M. Kado, K. Kahle, L. Kalinovskaya, J. Kalinowski, J. F. Kamenik, K. Kannike, S. O. Kara, H. Karadeniz, V. Karaventzas, I. Karpov, S. Kartal, A. Karyukhin, V. Kashikhin, J. Katharina Behr, U. Kaya, J. Keintzel, P. A. Keinz, K. Keppel, R. Kersevan, K. Kershaw, H. Khanpour, S. Khatibi, M. Khatiri Yanehsari, V. V. Khoze, J. Kieseler, A. Kilic, A. Kilpinen, Y.-K. Kim, D. W. Kim, U. Klein, M. Klein, F. Kling, N. Klinkenberg, S. Klöppel, M. Klute, V. I. Klyukhin, M. Knecht, B. Kniehl, F. Kocak, C. Koeberl, A. M. Kolano, A. Kollegger, K. Kołodziej, A. A. Kolomiets, J. Komppula, I. Koop, P. Koppenburg, M. Koratzinos, M. Kordiaczyńska, M. Korjik, O. Kortner, P. Kostka, W. Kotlarski, C. Kotnig, T. Köttig, A. V. Kotwal, A. D. Kovalenko, S. Kowalski, J. Kozaczuk, G. A. Kozlov, S. S. Kozub, A. M. Krainer, T. Kramer, M. Krämer, M. Krammer, A. A. Krasnov, F. Krauss, K. Kravalis, L. Kretzschmar, R. M. Kriske, H. Kritscher, P. Krkotic, H. Kroha, M. Kucharczyk, S. Kuday, A. Kuendig, G. Kuhlmann, A. Kulesza, Mi. Kumar, Mu. Kumar, A. Kusina, S. Kuttimalai, M. Kuze, T. Kwon, F. Lackner, M. Lackner, E. La Francesca, M. Laine, G. Lamanna, S. La Mendola, E. Lançon, G. Landsberg, P. Langacker, C. Lange, A. Langner, A. J. Lankford, J. P. Lansberg, T. Lari, P. J. Laycock, P. Lebrun, A. Lechner, K. Lee, S. Lee, R. Lee, T. Lefevre, P. Le Guen, T. Lehtinen, S. B. Leith, P. Lenzi, E. Leogrande, C. Leonidopoulos, I. Leon-Monzon, G. Lerner, O. Leroy, T. Lesiak, P. Lévai, A. Leveratto, E. Levichev, G. Li, S. Li, R. Li, D. Liberati, M. Liepe, D. A. Lissauer, Z. Liu, A. Lobko, E. Locci, E. Logothetis Agaliotis, M. P. Lombardo, A. J. Long, C. Lorin, R. Losito, A. Louzguiti, I. Low, D. Lucchesi, M. T. Lucchini, A. Luciani, M. Lueckhof, A. J. G. Lunt, M. Luzum, D. A. Lyubimtsev, M. Maggiora, N. Magnin, M. A. Mahmoud, F. Mahmoudi, J. Maitre, V. Makarenko, A. Malagoli, J. Malclés, L. Malgeri, P. J. Mallon, F. Maltoni, S. Malvezzi, O. B. Malyshev, G. Mancinelli, P. Mandrik, P. Manfrinetti, M. Mangano, P. Manil, M. Mannelli, G. Marchiori, F. Marhauser, V. Mariani, V. Marinozzi, S. Mariotto, P. Marquard, C. Marquet, T. Marriott-Dodington, R. Martin, O. Martin, J. Martin Camalich, T. Martinez, H. Martinez Bruzual, M. I. Martínez-Hernández, D. E. Martins, S. Marzani, D. Marzocca, L. Marzola, S. Masciocchi, I. Masina, A. Massimiliano, A. Massironi, T. Masubuchi, V. A. Matveev, M. A. Mazzoni, M. McCullough, P. A. McIntosh, P. Meade, L. Medina, A. Meier, J. Meignan, B. Mele, J. G. Mendes Saraiva, F. Menez, M. Mentink, E. Meoni, P. Meridiani, M. Merk, P. Mermod, V. Mertens, L. Mether, E. Métral, M. Migliorati, A. Milanese, C. Milardi, G. Milhano, B. L. Militsyn, F. Millet, I. Minashvili, J. V. Minervini, L. S. Miralles, D. Mirarchi, S. Mishima, D. P. Missiaen, G. Mitselmakher, T. Mitsuhashi, J. Mnich, M. Mohammadi Najafabadi, R. N. Mohapatra, N. Mokhov, J. G. Molson, R. Monge, C. Montag, G. Montagna, S. Monteil, G. Montenero, E. Montesinos, F. Moortgat, N. Morange, G. Morello, M. Moreno Llácer, M. Moretti, S. Moretti, A. K. Morley, A. Moros, I. Morozov, V. Morretta, M. Morrone, A. Mostacci, S. Muanza, N. Muchnoi, M. Mühlegger, M. Mulder, M. Mulders, B. Müller, F. Müller, A.-S. Müller, J. Munilla, M. J. Murray, Y. Muttoni, S. Myers, M. Mylona, J. Nachtman, T. Nakamoto, M. Nardecchia, G. Nardini, P. Nason, Z. Nergiz, A. V. Nesterenko, A. Nettsträter, C. Neubüser, J. Neundorf, F. Niccoli, O. Nicrosini, Y. Nie, U. Niedermayer, J. Niedziela, A. Niemi, S. A. Nikitin, A. Nisati, J. M. No, M. Nonis, Y. Nosochkov, M. Novák, A. Novokhatski, J. M. O’Callaghan, C. Ochando, S. Ogur, K. Ohmi, K. Oide, V. A. Okorokov, Y. Okumura, C. Oleari, F. I. Olness, Y. Onel, M. Ortino, J. Osborne, P. Osland, T. Otto, K. Y. Oyulmaz, A. Ozansoy, V. Özcan, K. Özdemir, C. E. Pagliarone, H. F. Pais da Silva, E. Palmieri, L. Palumbo, A. Pampaloni, R.-Q. Pan, M. Panareo, O. Panella, G. Panico, G. Panizzo, A. A. Pankov, V. Pantsyrny, C. G. Papadopoulos, A. Papaefstathiou, Y. Papaphilippou, M. A. Parker, V. Parma, M. Pasquali, S. K. Patra, R. Patterson, H. Paukkunen, F. Pauss, S. Peggs, J.-P. Penttinen, G. Peón, E. E. Perepelkin, E. Perez, J. C. Perez, G. Perez, F. Pérez, E. Perez Codina, J. Perez Morales, M. Perfilov, H. Pernegger, M. Peruzzi, C. Pes, K. Peters, S. Petracca, F. Petriello, L. Pezzotti, S. Pfeiffer, F. Piccinini, T. Pieloni, M. Pierini, H. Pikhartova, G. Pikurs, E. Pilicer, P. Piminov, C. Pira, R. Pittau, W. Płaczek, M. Plagge, T. Plehn, M.-A. Pleier, M. Płoskoń, M. Podeur, H. Podlech, T. Podzorny, L. Poggioli, A. Poiron, G. Polesello, M. Poli Lener, A. Polini, J. Polinski, S. M. Polozov, L. Ponce, M. Pont, L. Pontecorvo, T. Portaluri, K. Potamianos, C. Prasse, M. Prausa, A. Preinerstorfer, E. Premat, T. Price, M. Primavera, F. Prino, M. Prioli, J. Proudfoot, A. Provino, T. Pugnat, N. Pukhaeva, S. Puławski, D. Pulikowski, G. Punzi, M. Putti, A. Pyarelal, H. Quack, M. Quispe, A. Racioppi, H. Rafique, V. Raginel, M. Raidal, N. S. Ramírez-Uribe, M. J. Ramsey-Musolf, R. Rata, P. Ratoff, F. Ravotti, P. Rebello Teles, M. Reboud, S. Redaelli, E. Renner, A. E. Rentería-Olivo, M. Rescigno, J. Reuter, A. Ribon, A. M. Ricci, W. Riegler, S. Riemann, B. Riemann, T. Riemann, J. M. Rifflet, R. A. Rimmer, R. Rinaldesi, L. Rinolfi, O. Rios Rubiras, T. Risselada, A. Rivetti, L. Rivkin, T. Rizzo, T. Robens, F. Robert, A. J. Robson, E. Rochepault, C. Roda, G. Rodrigo, M. Rodríguez-Cahuantzi, C. Rogan, M. Roig, S. Rojas-Torres, J. Rojo, G. Rolandi, G. Rolando, P. Roloff, A. Romanenko, A. Romanov, F. Roncarolo, A. Rosado Sanchez, G. Rosaz, L. Rossi, A. Rossi, R. Rossmanith, B. Rousset, C. Royon, X. Ruan, I. Ruehl, V. Ruhlmann-Kleider, R. Ruiz, L. Rumyantsev, R. Ruprecht, A. I. Ryazanov, A. Saba, R. Sadykov, D. Saez de Jauregui, M. Sahin, B. Sailer, M. Saito, F. Sala, G. P. Salam, J. Salfeld-Nebgen, C. A. Salgado, S. Salini, J. M. Sallese, T. Salmi, A. Salzburger, O. A. Sampayo, S. Sanfilippo, J. Santiago, E. Santopinto, R. Santoro, A. Sanz Ull, X. Sarasola, I. H. Sarpün, M. Sauvain, S. Savelyeva, R. Sawada, G. F. R. Sborlini, A. Schaffer, M. Schaumann, M. Schenk, C. Scheuerlein, I. Schienbein, K. Schlenga, H. Schmickler, R. Schmidt, D. Schoerling, A. Schoning, T. Schörner-Sadenius, M. Schott, D. Schulte, P. Schwaller, C. Schwanenberger, P. Schwemling, N. Schwerg, L. Scibile, A. Sciuto, E. Scomparin, C. Sebastiani, B. Seeber, M. Segreti, P. Selva, M. Selvaggi, C. Senatore, A. Senol, L. Serin, M. Serluca, N. Serra, A. Seryi, L. Sestini, A. Sfyrla, M. Shaposhnikov, E. Shaposhnikova, B. Yu. Sharkov, D. Shatilov, J. Shelton, V. Shiltsev, I. P. Shipsey, G. D. Shirkov, A. Shivaji, D. Shwartz, T. Sian, S. Sidorov, A. Siemko, L. Silvestrini, N. Simand, F. Simon, B. K. Singh, A. Siódmok, Y. Sirois, E. Sirtori, R. Sirvinskaite, B. Sitar, T. Sjöstrand, P. Skands, E. Skordis, K. Skovpen, M. Skrzypek, E. Slade, P. Slavich, R. Slovak, V. Smaluk, V. Smirnov, W. Snoeys, L. Soffi, P. Sollander, O. Solovyanov, H. K. Soltveit, H. Song, P. Sopicki, M. Sorbi, L. Spallino, M. Spannowsky, B. Spataro, P. Sphicas, H. Spiesberger, P. Spiller, M. Spira, T. Srivastava, J. Stachel, A. Stakia, J. L. Stanyard, E. Starchenko, A. Yu. Starikov, A. M. Staśto, M. Statera, R. Steerenberg, J. Steggemann, A. Stenvall, F. Stivanello, D. Stöckinger, L. S. Stoel, M. Stöger-Pollach, B. Strauss, M. Stuart, G. Stupakov, S. Su, A. Sublet, K. Sugita, L. Sulak, M. K. Sullivan, S. Sultansoy, T. Sumida, K. Suzuki, G. Sylva, M. J. Syphers, A. Sznajder, M. Taborelli, N. A. Tahir, E. Tal Hod, M. Takeuchi, C. Tambasco, J. Tanaka, K. Tang, I. Tapan, S. Taroni, G. F. Tartarelli, G. Tassielli, L. Tavian, T. M. Taylor, G. N. Taylor, A. M. Teixeira, G. Tejeda-Muñoz, V. I. Telnov, R. Tenchini, H. H. J. ten Kate, K. Terashi, A. Tesi, M. Testa, C. Tetrel, D. Teytelman, J. Thaler, A. Thamm, S. Thomas, M. T. Tiirakari, V. Tikhomirov, D. Tikhonov, H. Timko, V. Tisserand, L. M. Tkachenko, J. Tkaczuk, J. Ph. Tock, B. Todd, E. Todesco, R. Tomás Garcia, D. Tommasini, G. Tonelli, F. Toral, T. Torims, R. Torre, Z. Townsend, R. Trant, D. Treille, L. Trentadue, A. Tricoli, A. Tricomi, W. Trischuk, I. S. Tropin, B. Tuchming, A. A. Tudora, B. Turbiarz, I. Turk Cakir, M. Turri, T. Tydecks, J. Usovitsch, J. Uythoven, R. Vaglio, A. Valassi, F. Valchkova, M. A. Valdivia Garcia, P. Valente, R. U. Valente, A.-M. Valente-Feliciano, G. Valentino, L. Vale Silva, J. M. Valet, R. Valizadeh, J. W. F. Valle, S. Vallecorsa, G. Vallone, M. van Leeuwen, U. H. van Rienen, L. van Riesen-Haupt, M. Varasteh, L. Vecchi, P. Vedrine, G. Velev, R. Veness, A. Ventura, W. Venturini Delsolaro, M. Verducci, C. B. Verhaaren, C. Vernieri, A. P. Verweij, O. Verwilligen, O. Viazlo, A. Vicini, G. Viehhauser, N. Vignaroli, M. Vignolo, A. Vitrano, I. Vivarelli, S. Vlachos, M. Vogel, D. M. Vogt, V. Völkl, P. Volkov, G. Volpini, J. von Ahnen, G. Vorotnikov, G. G. Voutsinas, V. Vysotsky, U. Wagner, R. Wallny, L.-T. Wang, R. Wang, K. Wang, B. F. L. Ward, T. P. Watson, N. K. Watson, Z. Wa̧s, C. Weiland, S. Weinzierl, C. P. Welsch, J. Wenninger, M. Widorski, U. A. Wiedemann, H.-U. Wienands, G. Wilkinson, P. H. Williams, A. Winter, A. Wohlfahrt, T. Wojtoń, D. Wollmann, J. Womersley, D. Woog, X. Wu, A. Wulzer, M. K. Yanehsari, G. Yang, H. J. Yang, W.-M. Yao, E. Yazgan, V. Yermolchik, Ay. Yilmaz, Al. Yilmaz, H.-D. Yoo, S. A. Yost, T. You, C. Young, T.-T. Yu, F. Yu, A. Zaborowska, S. G. Zadeh, M. Zahnd, M. Zanetti, L. Zanotto, L. Zawiejski, P. Zeiler, M. Zerlauth, S. M. Zernov, G. Zevi Dell Porta, Z. Zhang, Y. Zhang, C. Zhang, H. Zhang, Z. Zhao, Y.-M. Zhong, J. Zhou, D. Zhou, P. Zhuang, G. Zick, F. Zimmermann, J. Zinn-Justin, L. Zivkovic, A. V. Zlobin, M. Zobov, J. Zupan, J. Zurita, and The FCC Collaboration

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract We review the physics opportunities of the Future Circular Collider, covering its e+e-, pp, ep and heavy ion programmes. We describe the measurement capabilities of each FCC component, addressing the study of electroweak, Higgs and strong interactions, the top quark and flavour, as well as phenomena beyond the Standard Model. We highlight the synergy and complementarity of the different colliders, which will contribute to a uniquely coherent and ambitious research programme, providing an unmatchable combination of precision and sensitivity to new physics.

Published
2019
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5. Crossing the Cleft: Communication Challenges Between Neuroscience and Artificial Intelligence

Author

Frances S. Chance, James B. Aimone, Srideep S. Musuvathy, Michael R. Smith, Craig M. Vineyard, and Felix Wang

Subjects
artificial intelligence, neural-inspired algorithms, neuromorphic, deep learning, artificial neural network, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Historically, neuroscience principles have heavily influenced artificial intelligence (AI), for example the influence of the perceptron model, essentially a simple model of a biological neuron, on artificial neural networks. More recently, notable recent AI advances, for example the growing popularity of reinforcement learning, often appear more aligned with cognitive neuroscience or psychology, focusing on function at a relatively abstract level. At the same time, neuroscience stands poised to enter a new era of large-scale high-resolution data and appears more focused on underlying neural mechanisms or architectures that can, at times, seem rather removed from functional descriptions. While this might seem to foretell a new generation of AI approaches arising from a deeper exploration of neuroscience specifically for AI, the most direct path for achieving this is unclear. Here we discuss cultural differences between the two fields, including divergent priorities that should be considered when leveraging modern-day neuroscience for AI. For example, the two fields feed two very different applications that at times require potentially conflicting perspectives. We highlight small but significant cultural shifts that we feel would greatly facilitate increased synergy between the two fields.

Published
2020
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6. Measurement of the total cross section from elastic scattering in pp collisions at s=7 TeV with the ATLAS detector

Author

G. Aad, B. Abbott, J. Abdallah, S. Abdel Khalek, O. Abdinov, R. Aben, B. Abi, M. Abolins, O.S. AbouZeid, H. Abramowicz, H. Abreu, R. Abreu, Y. Abulaiti, B.S. Acharya, L. Adamczyk, D.L. Adams, J. Adelman, S. Adomeit, T. Adye, T. Agatonovic-Jovin, J.A. Aguilar-Saavedra, M. Agustoni, S.P. Ahlen, F. Ahmadov, G. Aielli, H. Akerstedt, T.P.A. Åkesson, G. Akimoto, A.V. Akimov, G.L. Alberghi, J. Albert, S. Albrand, M.J. Alconada Verzini, M. Aleksa, I.N. Aleksandrov, C. Alexa, G. Alexander, G. Alexandre, T. Alexopoulos, M. Alhroob, G. Alimonti, L. Alio, J. Alison, B.M.M. Allbrooke, L.J. Allison, P.P. Allport, J. Almond, A. Aloisio, A. Alonso, F. Alonso, C. Alpigiani, A. Altheimer, B. Alvarez Gonzalez, M.G. Alviggi, K. Amako, Y. Amaral Coutinho, C. Amelung, D. Amidei, S.P. Amor Dos Santos, A. Amorim, S. Amoroso, N. Amram, G. Amundsen, C. Anastopoulos, L.S. Ancu, N. Andari, T. Andeen, C.F. Anders, G. Anders, K.J. Anderson, A. Andreazza, V. Andrei, X.S. Anduaga, S. Angelidakis, I. Angelozzi, P. Anger, A. Angerami, F. Anghinolfi, A.V. Anisenkov, N. Anjos, A. Annovi, A. Antonaki, M. Antonelli, A. Antonov, J. Antos, F. Anulli, M. Aoki, L. Aperio Bella, R. Apolle, G. Arabidze, I. Aracena, Y. Arai, J.P. Araque, A.T.H. Arce, J-F. Arguin, S. Argyropoulos, M. Arik, A.J. Armbruster, O. Arnaez, V. Arnal, H. Arnold, M. Arratia, O. Arslan, A. Artamonov, G. Artoni, S. Asai, N. Asbah, A. Ashkenazi, B. Åsman, L. Asquith, K. Assamagan, R. Astalos, M. Atkinson, N.B. Atlay, B. Auerbach, K. Augsten, M. Aurousseau, G. Avolio, G. Azuelos, Y. Azuma, M.A. Baak, A.E. Baas, C. Bacci, H. Bachacou, K. Bachas, M. Backes, M. Backhaus, J. Backus Mayes, E. Badescu, P. Bagiacchi, P. Bagnaia, Y. Bai, T. Bain, J.T. Baines, O.K. Baker, P. Balek, F. Balli, E. Banas, Sw. Banerjee, A.A.E. Bannoura, V. Bansal, H.S. Bansil, L. Barak, S.P. Baranov, E.L. Barberio, D. Barberis, M. Barbero, T. Barillari, M. Barisonzi, T. Barklow, N. Barlow, B.M. Barnett, R.M. Barnett, Z. Barnovska, A. Baroncelli, G. Barone, A.J. Barr, F. Barreiro, J. Barreiro Guimarães da Costa, R. Bartoldus, A.E. Barton, P. Bartos, V. Bartsch, A. Bassalat, A. Basye, R.L. Bates, J.R. Batley, M. Battaglia, M. Battistin, F. Bauer, H.S. Bawa, M.D. Beattie, T. Beau, P.H. Beauchemin, R. Beccherle, P. Bechtle, H.P. Beck, K. Becker, S. Becker, M. Beckingham, C. Becot, A.J. Beddall, A. Beddall, S. Bedikian, V.A. Bednyakov, C.P. Bee, L.J. Beemster, T.A. Beermann, M. Begel, K. Behr, C. Belanger-Champagne, P.J. Bell, W.H. Bell, G. Bella, L. Bellagamba, A. Bellerive, M. Bellomo, K. Belotskiy, O. Beltramello, O. Benary, D. Benchekroun, K. Bendtz, N. Benekos, Y. Benhammou, E. Benhar Noccioli, J.A. Benitez Garcia, D.P. Benjamin, J.R. Bensinger, K. Benslama, S. Bentvelsen, D. Berge, E. Bergeaas Kuutmann, N. Berger, F. Berghaus, J. Beringer, C. Bernard, P. Bernat, C. Bernius, F.U. Bernlochner, T. Berry, P. Berta, C. Bertella, G. Bertoli, F. Bertolucci, C. Bertsche, D. Bertsche, M.I. Besana, G.J. Besjes, O. Bessidskaia, M. Bessner, N. Besson, C. Betancourt, S. Bethke, W. Bhimji, R.M. Bianchi, L. Bianchini, M. Bianco, O. Biebel, S.P. Bieniek, K. Bierwagen, J. Biesiada, M. Biglietti, J. Bilbao De Mendizabal, H. Bilokon, M. Bindi, S. Binet, A. Bingul, C. Bini, C.W. Black, J.E. Black, K.M. Black, D. Blackburn, R.E. Blair, J.-B. Blanchard, T. Blazek, I. Bloch, C. Blocker, W. Blum, U. Blumenschein, G.J. Bobbink, V.S. Bobrovnikov, S.S. Bocchetta, A. Bocci, C. Bock, C.R. Boddy, M. Boehler, T.T. Boek, J.A. Bogaerts, A.G. Bogdanchikov, A. Bogouch, C. Bohm, J. Bohm, V. Boisvert, T. Bold, V. Boldea, A.S. Boldyrev, M. Bomben, M. Bona, M. Boonekamp, A. Borisov, G. Borissov, M. Borri, S. Borroni, J. Bortfeldt, V. Bortolotto, K. Bos, D. Boscherini, M. Bosman, H. Boterenbrood, J. Boudreau, J. Bouffard, E.V. Bouhova-Thacker, D. Boumediene, C. Bourdarios, N. Bousson, S. Boutouil, A. Boveia, J. Boyd, I.R. Boyko, I. Bozic, J. Bracinik, A. Brandt, G. Brandt, O. Brandt, U. Bratzler, B. Brau, J.E. Brau, H.M. Braun, S.F. Brazzale, B. Brelier, K. Brendlinger, A.J. Brennan, R. Brenner, S. Bressler, K. Bristow, T.M. Bristow, D. Britton, F.M. Brochu, I. Brock, R. Brock, C. Bromberg, J. Bronner, G. Brooijmans, T. Brooks, W.K. Brooks, J. Brosamer, E. Brost, J. Brown, P.A. Bruckman de Renstrom, D. Bruncko, R. Bruneliere, S. Brunet, A. Bruni, G. Bruni, M. Bruschi, L. Bryngemark, T. Buanes, Q. Buat, F. Bucci, P. Buchholz, R.M. Buckingham, A.G. Buckley, S.I. Buda, I.A. Budagov, F. Buehrer, L. Bugge, M.K. Bugge, O. Bulekov, A.C. Bundock, H. Burckhart, S. Burdin, B. Burghgrave, S. Burke, I. Burmeister, E. Busato, D. Büscher, V. Büscher, P. Bussey, C.P. Buszello, B. Butler, J.M. Butler, A.I. Butt, C.M. Buttar, J.M. Butterworth, P. Butti, W. Buttinger, A. Buzatu, M. Byszewski, S. Cabrera Urbán, D. Caforio, O. Cakir, P. Calafiura, A. Calandri, G. Calderini, P. Calfayan, R. Calkins, L.P. Caloba, D. Calvet, S. Calvet, R. Camacho Toro, S. Camarda, D. Cameron, L.M. Caminada, R. Caminal Armadans, S. Campana, M. Campanelli, A. Campoverde, V. Canale, A. Canepa, M. Cano Bret, J. Cantero, R. Cantrill, T. Cao, M.D.M. Capeans Garrido, I. Caprini, M. Caprini, M. Capua, R. Caputo, R. Cardarelli, T. Carli, G. Carlino, L. Carminati, S. Caron, E. Carquin, G.D. Carrillo-Montoya, J.R. Carter, J. Carvalho, D. Casadei, M.P. Casado, M. Casolino, E. Castaneda-Miranda, A. Castelli, V. Castillo Gimenez, N.F. Castro, P. Catastini, A. Catinaccio, J.R. Catmore, A. Cattai, G. Cattani, J. Caudron, V. Cavaliere, D. Cavalli, M. Cavalli-Sforza, V. Cavasinni, F. Ceradini, B.C. Cerio, K. Cerny, A.S. Cerqueira, A. Cerri, L. Cerrito, F. Cerutti, M. Cerv, A. Cervelli, S.A. Cetin, A. Chafaq, D. Chakraborty, I. Chalupkova, S. Chance, P. Chang, B. Chapleau, J.D. Chapman, D. Charfeddine, D.G. Charlton, C.C. Chau, C.A. Chavez Barajas, S. Cheatham, A. Chegwidden, S. Chekanov, S.V. Chekulaev, G.A. Chelkov, M.A. Chelstowska, C. Chen, H. Chen, K. Chen, L. Chen, S. Chen, X. Chen, Y. Chen, H.C. Cheng, Y. Cheng, A. Cheplakov, R. Cherkaoui El Moursli, V. Chernyatin, E. Cheu, L. Chevalier, V. Chiarella, G. Chiefari, J.T. Childers, A. Chilingarov, G. Chiodini, A.S. Chisholm, R.T. Chislett, A. Chitan, M.V. Chizhov, S. Chouridou, B.K.B. Chow, D. Chromek-Burckhart, M.L. Chu, J. Chudoba, J.J. Chwastowski, L. Chytka, G. Ciapetti, A.K. Ciftci, R. Ciftci, D. Cinca, V. Cindro, A. Ciocio, P. Cirkovic, Z.H. Citron, M. Citterio, M. Ciubancan, A. Clark, P.J. Clark, R.N. Clarke, W. Cleland, J.C. Clemens, C. Clement, Y. Coadou, M. Cobal, A. Coccaro, J. Cochran, L. Coffey, J.G. Cogan, J. Coggeshall, B. Cole, S. Cole, A.P. Colijn, J. Collot, T. Colombo, G. Colon, G. Compostella, P. Conde Muiño, E. Coniavitis, M.C. Conidi, S.H. Connell, I.A. Connelly, S.M. Consonni, V. Consorti, S. Constantinescu, C. Conta, G. Conti, F. Conventi, M. Cooke, B.D. Cooper, A.M. Cooper-Sarkar, N.J. Cooper-Smith, K. Copic, T. Cornelissen, M. Corradi, F. Corriveau, A. Corso-Radu, A. Cortes-Gonzalez, G. Cortiana, G. Costa, M.J. Costa, D. Costanzo, D. Côté, G. Cottin, G. Cowan, B.E. Cox, K. Cranmer, G. Cree, S. Crépé-Renaudin, F. Crescioli, W.A. Cribbs, M. Crispin Ortuzar, M. Cristinziani, V. Croft, G. Crosetti, C.-M. Cuciuc, T. Cuhadar Donszelmann, J. Cummings, M. Curatolo, C. Cuthbert, H. Czirr, P. Czodrowski, Z. Czyczula, S. D'Auria, M. D'Onofrio, M.J. Da Cunha Sargedas De Sousa, C. Da Via, W. Dabrowski, A. Dafinca, T. Dai, O. Dale, F. Dallaire, C. Dallapiccola, M. Dam, A.C. Daniells, M. Dano Hoffmann, V. Dao, G. Darbo, S. Darmora, J. Dassoulas, A. Dattagupta, W. Davey, C. David, T. Davidek, E. Davies, M. Davies, O. Davignon, A.R. Davison, P. Davison, Y. Davygora, E. Dawe, I. Dawson, R.K. Daya-Ishmukhametova, K. De, R. de Asmundis, S. De Castro, S. De Cecco, N. De Groot, P. de Jong, H. De la Torre, F. De Lorenzi, L. De Nooij, D. De Pedis, A. De Salvo, U. De Sanctis, A. De Santo, J.B. De Vivie De Regie, W.J. Dearnaley, R. Debbe, C. Debenedetti, B. Dechenaux, D.V. Dedovich, I. Deigaard, J. Del Peso, T. Del Prete, F. Deliot, C.M. 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Zurzolo, V. Zutshi, and L. Zwalinski

Subjects
Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

A measurement of the total pp cross section at the LHC at s=7 TeV is presented. In a special run with high-β⋆ beam optics, an integrated luminosity of 80 μb−1 was accumulated in order to measure the differential elastic cross section as a function of the Mandelstam momentum transfer variable t. The measurement is performed with the ALFA sub-detector of ATLAS. Using a fit to the differential elastic cross section in the |t| range from 0.01 GeV2 to 0.1 GeV2 to extrapolate to |t|→0, the total cross section, σtot(pp→X), is measured via the optical theorem to be: σtot(pp→X)=95.35±0.38(stat.)±1.25(exp.)±0.37(extr.)mb, where the first error is statistical, the second accounts for all experimental systematic uncertainties and the last is related to uncertainties in the extrapolation to |t|→0. In addition, the slope of the elastic cross section at small |t| is determined to be B=19.73±0.14(stat.)±0.26(syst.) GeV−2.

Published
2014
Full Text
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7. HE-LHC: The High-Energy Large Hadron Collider Future Circular Collider Conceptual Design Report Volume 4

Author

Pushpalatha C Bhat, B. Seeber, C. Pagliarone, Marco Statera, Victor P. Goncalves, Daria Astapovych, W. Bartmann, S. Iwamoto, M. Mentink, Alessandro Tricoli, E. R. Bielert, Laurent Chevalier, Patrick Koppenburg, Marco Calviani, C. Montag, P. Spiller, Jan Uythoven, P. Di Nezza, G. Guillermo Canton, B. Sailer, Markus Elsing, Sara Khatibi, Luca Vecchi, Luigi Palumbo, J. P. Penttinen, T. Podzorny, Maneesh Kumar, J. M. Rifflet, C. Kotnig, Jean Zinn-Justin, Christopher B. Verhaaren, A. Chernoded, Alessandro Bertarelli, L. M. Tkachenko, C. Koeberl, P. J. Mallon, M. Takeuchi, W. Venturini Delsolaro, G. Lamanna, S. Weinzierl, J. Gao, W. Kaabi, David D'Enterria, D. Barna, Paolo Castelnovo, Rajat Gupta, Oliver Boine-Frankenheim, Adarsh Pyarelal, Andreas Salzburger, Tessa Charles, M.E. Biagini, O. Panella, M. Stuart, A. Kollegger, V. Garcia Diaz, Olcay Bolukbasi, Maurizio Pierini, H. Aksakal, Tord Riemann, Abhishek M. Iyer, V. Shiltsev, D. Buttazzo, J. Blümlein, Prateek Agrawal, L. Sestini, Martin Bauer, Felicitas Pauss, S. Fiorendi, F. Bossu, Marco Nardecchia, C. Leonidopoulos, Wojciech Kotlarski, A. Saba, I. Bautista-Guzmán, W. Hillert, Giorgio Ambrosio, T. Lehtinen, Michael Andrew Parker, Silvia Taroni, Gian F. Giudice, Ph. Lebrun, Johann A. Briffa, T. Risselada, Giuseppe Lerner, A. Lechner, L. S. Miralles, M. Kuze, J. M. Valet, P. S. B. Dev, S. Holleis, Ph. Schwemling, M. Biglietti, S. Banerjee, Thomas Schörner-Sadenius, A. Sanz Ull, V. Tikhomirov, S. Savelyeva, Jiayin Gu, D. Zhou, Federico Ravotti, S. A. Bogacz, Daniele Mirarchi, R. Tomás García, Yann Coadou, F. Yu, Y. Cai, T. Lari, F. Holdener, D. Shwartz, C. Bhat, Ramesh Gupta, Markus Klute, E. Palmieri, P. Collier, Branislav Sitar, Yves Sirois, Livio Fanò, S. Rojas-Torres, E. Locci, Ruben Garcia Alia, I. Božović Jelisavić, R. Chehab, J. A. Aguilar-Saavedra, M. Pasquali, A. Di Cicco, Bernhard Auchmann, Klaus Heinemann, Alessia Tricomi, D. Lucchesi, B. Haerer, M. Morrone, Paolo Giacomelli, Sonia Carra, A. Senol, Ivan Koop, Luca Silvestrini, Anna Stakia, Heather Gray, E. Skordis, A. D. Kovalenko, Paul Langacker, R. Li, Bernardo Bordini, R. Rata, Arjan Verweij, Shehu S. AbdusSalam, Andrey Karyukhin, U. van Rienen, Gianluigi Arduini, Bernhard Holzer, S. A. Nikitin, S. S. Kozub, Satoshi Mishima, B. Di Micco, S. Izquierdo Bermudez, N. Pukhaeva, Nigel Watson, F. Prino, Jean-Michel Sallese, Sotirios Vlachos, Alessandro Vicini, A. Valassi, Daniel Treille, F. Dordei, A. M. Fernandez Navarro, B. Dziewit, Marcello Abbrescia, J. M. Hauptman, I. Chaikovska, Paolo Giubellino, Michael J. Baker, V.V. Kashikhin, Friedrich Lackner, Filippo Sala, A. Langner, D. Pulikowski, H. Eriksson, Matteo Turri, Andrea Wulzer, M. Aiba, Lisa Borgonovi, I. Morozov, V. Haurylavets, J. F. Croteau, S. Boselli, L. A. Gonzalez Gomez, Claudia Tambasco, F. Mahmoudi, Sébastien Descotes-Genon, A. Luciani, Pavel Piminov, M. Varasteh, T. Herzig, Sandra Aumon, Cristina Bernini, Joseph Bramante, Roberta Arnaldi, G. Zick, Daniel Schulte, R. Santoro, Anna Kulesza, I. Turk Cakir, M. Nonis, Silvia Posada Arias, Livia Soffi, T. Wojtoń, E. Cennini, Florian Bauer, B. Rousset, J.-L. Grenard, C. Neubüser, Frederic Derue, Loukas Gouskos, Rainer Wallny, G. Calderini, M. Merk, M. Mühlegger, Roberto Cimino, M. Ramsey-Musolf, P. Rebello Teles, Mario Galanti, Mikhail Shaposhnikov, A. Andreazza, Maria Vittoria Garzelli, Masaya Ishino, José W. F. Valle, Colin Bernet, G. Velev, Cristina Botta, E. Fischer, J. Malclés, Giuseppe Montenero, Tripurari Srivastava, E. Renner, Shahnam Gorgi Zadeh, D. Cantore-Cavalli, Paul Laycock, J. Komppula, Simon C. Hopkins, Helmut Burkhardt, Eric Lancon, I. Aichinger, Andre Sznajder, F. Bordry, Massimo Giovannozzi, Aidan Robson, Anna Giunta, A. Carvalho, S. Farinon, Daniel Wollmann, M. Fouaidy, Martti Raidal, R. Gerard, Giovanni Volpini, U. Niedermayer, A. Alekou, Alexander J.G. Lunt, Vincenzo Cavasinni, Andrzej Siodmok, U. Kaya, Matthias Schott, Marumi Kado, S. A. Arsenyev, José Zurita, John Osborne, Patrick Meade, Gianmarco Bovone, G. Li, Klaus Schlenga, Antti Stenvall, D. Duellmann, Werner Riegler, I. Garzia, Yasuyuki Okumura, G. Pikurs, F. Maltoni, Massimo Sorbi, M. Arzeo, B. Strauss, Y. W. Baek, Mauro Chiesa, K. Ilyina-Brunner, Javier L. Albacete, R. Farinelli, C. Pes, Nicolas Morange, S. M. Zernov, U. Wagner, Emmanuelle Perez, G. G. Da Silveira, J. Neundorf, Néstor Armesto, T. Hahn, Roman N. Lee, Roderik Bruce, B. Y. Sharkov, T. du Pree, G. Cibinetto, Evelin Meoni, R. Rinaldesi, James A. Ellison, Radim Slovak, Silvia Franchino, Mikko Laine, T. Pugnat, S. P. Das, Yuji Enari, Emanuela Barzi, Cihan Bayindir, R. Boels, Jana Faltova, M. Moreno Llácer, Scott A. Yost, Michael Spannowsky, Florian Burkart, Marcin Chrzaszcz, K. Suzuki, Luca Trentadue, S. Masciocchi, Gilad Perez, Steve Peggs, K. Sugita, Eleonora Belli, Carmine Senatore, K. Y. Oyulmaz, Aldo Deandrea, Irakli Minashvili, Desmond P. Barber, M. I. Martínez-Hernández, A. Apyan, S. 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Kalinowski, Michele Cascella, Francesco Giffoni, Alessandro Polini, Georges Azuelos, M. Prioli, Wolfgang Altmannshofer, S. K. Patra, H. J. He, J. J. Aguilera-Verdugo, Hannu Paukkunen, P. Chomaz, Shoji Asai, Nicolas Magnin, Gavin P. Salam, R. Wang, F. Avino, Alexander Romanenko, A. Rossi, Steve Muanza, Richard Ruiz, Dmitry Teytelman, S. Klöppel, S. Atieh, M. Mohammadi Najafabadi, L. Apolinario, Andrea Tesi, M. Maggiora, A. Falkowski, Janusz Gluza, M. Sauvain, Hamzeh Khanpour, S. Chance, Ansgar Denner, Ma. Greco, Andreas Papaefstathiou, Manuela Boscolo, Joydeep Chakrabortty, E. Franco, R. R. Bosley, G. Peón, Fred Olness, Simone Alioli, Andrea Gaddi, M. K. Sullivan, M. Segreti, M. Panareo, Florian Goertz, Z. G. Zhao, H. Chanal, O. Martin, P. Azzurri, Agnieszka Chmielinska, M. Kordiaczyńska, O. Brunner, J. Von Ahnen, Jose Santiago, K. Foraz, Y. Alexahin, Marcello Mannelli, Christian Schwanenberger, S. Ganjour, Simone Marzani, T. M. Taylor, S. Di Vita, J. Womersley, I. 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Saez de Jauregui, Maria Rescigno, Stephan Eisenhardt, Andrea Dainese, Z. Drásal, G. H. Corral, J. M. Camalich, John Ellis, E. Gabrielli, L. Rumyantsev, A. Caliskan, K. Brunner, K. Tang, P. Sopicki, J. Fan, Marcin Kucharczyk, S. Gorgi Zadeh, Carlos A. Salgado, Simone Bologna, Y. Muttoni, A. Chancé, Patrick Jenny, Mark Boland, G. Yang, G. Wilkinson, Roger J. Hernández-Pinto, M. Novák, Gennady Stupakov, E. Jensen, Lance D. Cooley, Torbjörn Sjöstrand, S. Su, Matthew Luzum, J. Casas, Per Osland, T. Robens, Oscar A. Sampayo, Evgeny Levichev, P. N. Ratoff, G. Rolandi, M. A. Valdivia Garcia, Anthony Keith Morley, L. van Riesen-Haupt, A. Sublet, M. A. Mazzoni, J.L. Gutierrez, A. Abramov, Abbas Kenan Ciftci, A. Provino, L. Delle Rose, John Fox, Barry M. Dillon, V. Smirnov, G. N. Taylor, Anke-Susanne Müller, C. Pira, Fulvio Piccinini, A. Faus-Golfe, Pietro Antonioli, S. Sanfilippo, Julien Cogan, A. Ribon, Andrew Hutton, Frank Zimmermann, Lev Dudko, Erez Etzion, J. Polinski, G. Bencivenni, M. Gil Costa, L. K. Gladilin, Yannis Papaphilippou, Michael Spira, Maria Paola Lombardo, M. Fiascaris, Darius A. Faroughy, S. O. Kara, Peter Braun-Munzinger, A. Wohlfahrt, A. A. Krasnov, S.A. Gourlay, W. Da Silva, Jacqueline Keintzel, Radja Boughezal, Renat Sadykov, L. R. Sulak, Valentin V. Khoze, T. Tydecks, S. Puławski, Daniel de Florian, Pedro Schwaller, A. Akay, Nicola Serra, Sukanta Dutta, Christophe Royon, Alessandro Ricci, A. Kuendig, C. G. Honorato, K. Kołodziej, L. Deniau, Michael Kramer, J. Ferradas Troitino, A. Arbey, A. M. Staśto, Marcel Demarteau, Ralph Aßmann, O. Grimm, D. Forkel-Wirth, Owain Rhodri Jones, A. M. Kolano, G. Chiarello, William Trischuk, Andrea Dell'Acqua, Elisabetta Gallo, H. Song, Frank Petriello, N. Ibarrola, C. Colldelram, A. I. Ryazanov, A. Meier, Phillip Allport, J. de Blas, S. Chattopadhyay, Massimo Florio, X. Jiang, Bertrand Baudouy, T. Otto, Tevong You, Christoph Englert, Roberto Pittau, G. M. Bilei, Matthew McCullough, N. S. Ramírez-Uribe, J. Charles, Amalia Ballarino, Federico Antinori, A. V. Kotwal, P. Le Guen, Berndt Müller, Chiara Roda, Xavier Buffat, D. K. Hong, Matthias Liepe, G. Gorine, V. A. Okorokov, D. Bozzini, N. Simand, Giuseppe Francesco Tartarelli, C. Marquet, R. Contino, A. M. Teixeira, R. Trant, Roberto Losito, M. Quispe, Valery I. Telnov, Helga Timko, D. Lissauer, Giulio Aielli, Giorgio Chiarelli, M. J. Baldwin, A. Winter, X. Sarasola, E. E. Boos, Aleandro Nisati, Cedric Garion, Monica D'Onofrio, S. M. Gascon-Shotkin, Daniele Barducci, G. Rosaz, Nathaniel Craig, L. D’Aloia Schwartzentruber, A. Falou, A. Henriques, Tobias Hurth, Michael Eisterer, Andreas Grau, Austin Ball, D. Delikaris, P. A. McIntosh, E. Graverini, Kadri Ozdemir, F. Valchkova, Marco Zanetti, Guenakh Mitselmakher, S. Albergo, Peter Levai, Caterina Vernieri, F. Stivanello, Michael Barnes, Henri Bachacou, Daniel Fournier, L. T. Wang, D. Boutin, S. Moretti, B. Riemann, Michael Murray, Aleksandr Azatov, C. T. A. Cook, Valentina Maria Cairo, J. B. De Vivie De Regie, H. Schmickler, M. Schenk, Georgios Voutsinas, André Schöning, S. G. Bondarenko, Giorgio Bellomo, Andrei Seryi, Jane Nachtman, Clement Helsens, E. De Lucia, Jakob Salfeld-Nebgen, Lorenzo Pezzotti, Z. Townsend, B. Dalena, Mogens Dam, Yasar Onel, Yi-Ming Zhong, B. Curé, A. A. Kolomiets, A. M. Valente-Feliciano, Laurette Ponce, David Olivier Jamin, P. Krkotic, Alexandre Louzguiti, Marina Putti, Holger Podlech, Petr Volkov, M. Angelucci, F. Duval, I. Hiekkanen, W. M. Yao, Giancarlo Ferrera, C. Lorin, Y. Dydyshka, Kurt R. Peters, Gergely Gabor Barnafoldi, V. Vysotsky, V. Arı, E. Pilicer, M. Chamizo-Llatas, G. Kuhlmann, Hans Quack, R. Valizadeh, Tiina Salmi, Thomas Kramer, Adam Jeff, A. Abada, J. M. Duval, J. Abelleira Fernandez, A. Leveratto, E. Tal Hod, X. Wu, Laurent Serin, Sarah Aull, Samuele Mariotto, A. Poiron, Sabine Riemann, P. Selva, V. I. Pantsyrny, Gianluca Valentino, K. Kahle, S. Aune, K. Potamianos, Eros Cazzato, M. Giovannetti, Petr Mandrik, S. Sidorov, F. Collamati, Simone Gilardoni, S. Bertolucci, Alexander V. Zlobin, Mehmet Sahin, Marco Delmastro, G. Aydın, A. Doblhammer, Alan S. Cornell, S. J. De Jong, M. Caccia, M. Lueckhof, P. Sollander, Mauro Taborelli, J. Shelton, Frank Gerigk, Robert Rimmer, Ayres Freitas, Pierluigi Bruzzone, Brajesh K. Singh, K. Keppel, N. Alipour Tehrani, C. Prasse, Louis Rinolfi, Emma Slade, W. Flieger, Alexey Dudarev, H. J. Yang, T. Köttig, L. Mether, C. Weiland, Andrea Malagoli, Sunghoon Jung, F. Conventi, I. Tropin, G. H. A. Viehhauser, Tomas Davidek, Y. O. Günaydin, Daniel Andreas Britzger, F. Toral, James John Brooke, R. Steerenberg, G. Morello, Mauro Migliorati, Alexej Grudiev, C. Tetrel, Wolfgang Höfle, J. V. Minervini, L. García Tabarés, V. Yermolchik, Claude Guyot, D. Guadagnoli, Giorgio Vallone, N. De Filippis, Oleksii Beznosov, P. Charitos, N. Schwerg, Ahmed Hammad, P. Manil, F. Niccoli, Lydia Iconomidou-Fayard, R. Aleksan, K. Hahn, P. Meridiani, Peter Skands, Tobias Golling, Lucio Rossi, G. Gobbi, Michael Hance, A. J. Barr, V. Del Duca, V. Guzey, M. Pont, Michele Selvaggi, Oliver Brüning, J. Barreiro Guimarães da Costa, A. Drago, Y. Zhang, Giovanni Punzi, Viktor Matveev, Anadi Canepa, Clemens Lange, B. L. Militsyn, Martijn Mulders, Max Klein, V. D’Auria, M. Mylona, Valeria Braccini, S. DasBakshi, David Calvet, Sophia Borowka, David Marzocca, S. Jadach, A. A. Pankov, Christophe Ochando, A. A. Tudora, I. Masina, Jure Zupan, A. Preinerstorfer, Benjamin Fuks, H. K. Soltveit, G. Rolando, E.E. Perepelkin, T. G. Rizzo, Saleh Sultansoy, Federico Roncarolo, K. Elsener, R. Q. Pan, P. Zhuang, David Attié, Jac Perez, K. Kravalis, F. Anulli, V. Ruhlmann-Kleider, S. Malvezzi, Steffen A. Bass, E. La Francesca, Heinz Pernegger, K. Grzanka, M. T. Tiirakari, Alberto Ventura, Alessandro Cerri, Marco Peruzzi, Eric Montesinos, O. Etisken, F. Grancagnolo, S. Kartal, H. Humer, Oliver Fischer, M. Primavera, Marco Toliman Lucchini, P. Vedrine, Felix Kling, M. Altınlı, Sergio Calatroni, C. Han, Olivier Leroy, R. T. D’Agnolo, N. Klinkenberg, A. Audurier, Tatsushi Nakamoto, Ali Bozbey, Bernd A. Kniehl, Carl J. Debono, I. P. J. Shipsey, Gregorio Bernardi, Paolo Nason, William James Fawcett, J. M. Jiménez, D. Denisov, M. Serluca, David Curtin, Arif Akhundov, M. García Pérez, Iacopo Vivarelli, Emanuele Bacchiocchi, Markus Zerlauth, Julia Hrdinka, F. Butin, F. Müller, D. Tikhonov, Jorg Wenninger, A. Kilic, Fabrizio Ferro, J. Tanaka, S. A. Antipov, Miroslav Atanasov, S. Kuttimalai, A. Y. Starikov, F. R. Blánquez, S. V. Furuseth, G. Gaudio, L. Malgeri, J. Curti, B. Turbiarz, S. Li, A. Romanov, Costas G. Papadopoulos, Brennan Goddard, Frank Krauss, Lidija Zivkovic, Toms Torims, Michaela Lackner, D. A. Lyubimtsev, G. Borghello, J. F. Grosse-Oetringhaus, A. Bogomyagkov, H. Duran Yildiz, N. Foppiani, Arthur Schaffer, J. Zhou, D. Liberati, Vincenzo Guidi, Naeem A. Tahir, M. Besançon, Daniel Schoerling, Joe Incandela, Giacomo Polesello, O. Cakir, I. Ruehl, Ruggero Vaglio, Z. Zhang, Bruno Spataro, Davide Tommasini, F. Millet, H. D. Yoo, Carlo V. Fiorio, S. Deghaye, C. Bozzi, A. Shivaji, G. Corcella, I. Bellafont, Valentina Mariani, D. E. Martins, Michael Syphers, C. Hati, Peter Marquard, Nicola Bacchetta, Matthew Crouch, David Woog, Oliver Kortner, A. Milanese, Ricardo Gonçalo, Guido Montagna, Mikhail Zobov, F. Bedeschi, Eugene Bulyak, M. Aburaia, R. Tenchini, G. Marchiori, H. Rafique, G. Calderola, M. Antonello, Andrea Thamm, S. Glukhov, F. Hug, Robert Ruprecht, Veysi Erkcan Ozcan, K. Lee, Angelo Infantino, V. Makarenko, Z. Nergiz, Sergei Chekanov, Benjamin C. Allanach, C. Dachauer, H. Zhang, C. Biscari, A. J. Lankford, Scott Thomas, P. Kostka, Thomas Gehrmann, O. Azzolini, M. Ploskon, S. F. Ge, K. Oide, Andrea Bastianin, Daniela Bortoletto, Ingo Schienbein, J. L. Biarrotte, M. van Leeuwen, D. Stöckinger, Harald Ita, J. Katharina Behr, A. Cholakian, T. Kwon, L. Medina, Evgeny Starchenko, G. Mancinelli, L. Zanotto, F. Menez, L. Bellagamba, J. P. 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Béguin, Roberto Cardarelli, C. Milardi, G. Tassielli, Mario Campanelli, P. Fabbricatore, R. Rossmanith, Piergiulio Lenzi, D. P. Missiaen, R. Patterson, Sigve Haug, A. Farilla, Guilherme Milhano, D. El Khechen, Freya Blekman, O. B. Malyshev, Carlo Ferdeghini, A. Hannah, Michael Benedikt, E. Logothetis Agaliotis, M. Prausa, Maurizio Vignolo, M. Drewes, F. Marhauser, A. Ivanovs, M. Widorski, E. Santopinto, Javier Munilla, V. Mertens, Filip Moortgat, Salim Ogur, Michaela Schaumann, O. Rios Rubiras, Carsten Welsch, Fady Bishara, Michael Plagge, M. Czech, Giuseppe Iacobucci, I. Crespo Garrido, W. Dallapiazza, A. Moros, Wieslaw Placzek, A. E. Rentería-Olivo, M. Saito, H. U. Wienands, O. Verwilligen, L. Spallino, W. Snoeys, L. Duarte, A. Massimiliano, Greg Landsberg, Z. Liu, A. Ozansoy, Antonella Sciuto, T. Boccali, R. B. Appleby, M. Antonelli, J. A. Netto, Y. Nie, Johannes Gutleber, M. Skrzypek, N. Vignaroli, P. J. Clark, Emilio Bellingeri, Bennie F.L. Ward, P. Roloff, E. Perez Codina, Roman Martin, Elias Metral, B. Hegner, L. Zawiejski, Efe Yazgan, F. Couderc, G. Tonelli, G. Castorina, Patrizia Azzi, A. De Roeck, Jean-Philippe Lansberg, Riccardo Valente, A. David, F. Robert, Jeremi Niedziela, Anna Grassellino, Marie-Hélène Genest, V. Tisserand, A. Kilpinen, Y. K. Kim, A. Dominjon, Andrej Arbuzov, David Amorim, L. Kretzschmar, E. Bruna, Sergey Polozov, Vyacheslav Klyukhin, Hubert Kroha, O. Amstutz, A. Vitrano, Raymond Veness, Tilman Plehn, M. A. Mahmoud, Uşak Üniversitesi, Fen Edebiyat Fakültesi, Fizik Bölümü, FCC Collaboration (Ukupan broj autora: 1363), FCC Collaboration, Abada, A., Abbrescia, M., Abdussalam, S. S., Abdyukhanov, I., Abelleira Fernandez, J., Abramov, A., Aburaia, M., Acar, A. O., Adzic, P. R., Agrawal, P., Aguilar-Saavedra, J. A., Aguilera-Verdugo, J. J., Aiba, M., Aichinger, I., Aielli, G., Akay, A., Akhundov, A., Aksakal, H., Albacete, J. L., Albergo, S., Alekou, A., Aleksa, M., Aleksan, R., Alemany Fernandez, R. 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C., Hati, C., Haug, S., Hauptman, J., Haurylavets, V., He, H. -J., Hegglin, A., Hegner, B., Heinemann, K., Heinemeyer, S., Helsens, C., Henriques, A., Hernandez, P., Hernandez-Pinto, R. J., Hernandez-Sanchez, J., Herzig, T., Hiekkanen, I., Hillert, W., Hoehn, T., Hofer, M., Hofle, W., Holdener, F., Holleis, S., Holzer, B., Hong, D. K., Honorato, C. G., Hopkins, S. C., Hrdinka, J., Hug, F., Humann, B., Humer, H., Hurth, T., Hutton, A., Iacobucci, G., Ibarrola, N., Iconomidou-Fayard, L., Ilyina-Brunner, K., Incandela, J., Infantino, A., Ippolito, V., Ishino, M., Islam, R., Ita, H., Ivanovs, A., Iwamoto, S., Iyer, A., Izquierdo Bermudez, S., Jadach, S., Jamin, D. O., Janot, P., Jarry, P., Jeff, A., Jenny, P., Jensen, E., Jensen, M., Jiang, X., Jimenez, J. M., Jones, M. A., Jones, O. R., Jowett, J. M., Jung, S., Kaabi, W., Kado, M., Kahle, K., Kalinovskaya, L., Kalinowski, J., Kamenik, J. F., Kannike, K., Kara, S. 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C., Perez, G., Perez, F., Perez Codina, E., Perez Morales, J., Perfilov, M., Pernegger, H., Peruzzi, M., Pes, C., Peters, K., Petracca, S., Petriello, F., Pezzotti, L., Pfeiffer, S., Piccinini, F., Pieloni, T., Pierini, M., Pikhartova, H., Pikurs, G., Pilicer, E., Piminov, P., Pira, C., Pittau, R., Placzek, W., Plagge, M., Plehn, T., Pleier, M. -A., Ploskon, M., Podeur, M., Podlech, H., Podzorny, T., Poggioli, L., Poiron, A., Polesello, G., Poli Lener, M., Polini, A., Polinski, J., Polozov, S. M., Ponce, L., Pont, M., Pontecorvo, L., Portaluri, T., Potamianos, K., Prasse, C., Prausa, M., Preinerstorfer, A., Premat, E., Price, T., Primavera, M., Prino, F., Prioli, M., Proudfoot, J., Provino, A., Pugnat, T., Pukhaeva, N., Pulawski, S., Pulikowski, D., Punzi, G., Putti, M., Pyarelal, A., Quack, H., Quispe, M., Racioppi, A., Rafique, H., Raginel, V., Raidal, M., Ramirez-Uribe, N. S., Ramsey-Musolf, M. 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Zurita, J, Işık Üniversitesi, Mühendislik Fakültesi, İnşaat Mühendisliği Bölümü, Işık University, Faculty of Engineering, Department of Civil Engineering, Bayındır, Cihan, Universitat Politècnica de Catalunya. Departament de Teoria del Senyal i Comunicacions, Universitat Politècnica de Catalunya. RF&MW - Grup de Recerca de sistemes, dispositius i materials de RF i microones, Abada A., Abbrescia M., AbdusSalam S.S., Abdyukhanov I., Abelleira Fernandez J., Abramov A., Aburaia M., Acar A.O., Adzic P.R., Agrawal P., Aguilar-Saavedra J.A., Aguilera-Verdugo J.J., Aiba M., Aichinger I., Aielli G., Akay A., Akhundov A., Aksakal H., Albacete J.L., Albergo S., Alekou A., Aleksa M., Aleksan R., Alemany Fernandez R.M., Alexahin Y., Alia R.G., Alioli S., Alipour Tehrani N., Allanach B.C., Allport P.P., Altinli M., Altmannshofer W., Ambrosio G., Amorim D., Amstutz O., Anderlini L., Andreazza A., Andreini M., Andriatis A., Andris C., Andronic A., Angelucci M., Antinori F., Antipov S.A., Antonelli M., Antonello M., Antonioli P., Antusch S., Anulli F., Apolinario L., Apollinari G., Apollonio A., Appelo D., Appleby R.B., Apyan A., Arbey A., Arbuzov A., Arduini G., Ari V., Arias S., Armesto N., Arnaldi R., Arsenyev S.A., Arzeo M., Asai S., Aslanides E., Assmann R.W., Astapovych D., Atanasov M., Atieh S., Attie D., Auchmann B., Audurier A., Aull S., Aumon S., Aune S., Avino F., Avrillaud G., Aydin G., Azatov A., Azuelos G., Azzi P., Azzolini O., Azzurri P., Bacchetta N., Bacchiocchi E., Bachacou H., Baek Y.W., Baglin V., Bai Y., Baird S., Baker M.J., Baldwin M.J., Ball A.H., Ballarino A., Banerjee S., Barber D.P., Barducci D., Barjhoux P., Barna D., Barnafoldi G.G., Barnes M.J., Barr A., Barranco Garcia J., Barreiro Guimaraes da Costa J., Bartmann W., Baryshevsky V., Barzi E., Bass S.A., Bastianin A., Baudouy B., Bauer F., Bauer M., Baumgartner T., Bautista-Guzman I., Bayindir C., Beaudette F., Bedeschi F., Beguin M., Bellafont I., Bellagamba L., Bellegarde N., Belli E., Bellingeri E., Bellini F., Bellomo G., Belomestnykh S., Bencivenni G., Benedikt M., Bernardi G., Bernardi J., Bernet C., Bernhardt J.M., Bernini C., Berriaud C., Bertarelli A., Bertolucci S., Besana M.I., Besancon M., Beznosov O., Bhat P., Bhat C., Biagini M.E., Biarrotte J.-L., Bibet Chevalier A., Bielert E.R., Biglietti M., Bilei G.M., Bilki B., Biscari C., Bishara F., Blanco-Garcia O.R., Blanquez F.R., Blekman F., Blondel A., Blumlein J., Boccali T., Boels R., Bogacz S.A., Bogomyagkov A., Boine-Frankenheim O., Boland M.J., Bologna S., Bolukbasi O., Bomben M., Bondarenko S., Bonvini M., Boos E., Bordini B., Bordry F., Borghello G., Borgonovi L., Borowka S., Bortoletto D., Boscherini D., Boscolo M., Boselli S., Bosley R.R., Bossu F., Botta C., Bottura L., Boughezal R., Boutin D., Bovone G., Bozovic Jelisavic I., Bozbey A., Bozzi C., Bozzini D., Braccini V., Braibant-Giacomelli S., Bramante J., Braun-Munzinger P., Briffa J.A., Britzger D., Brodsky S.J., Brooke J.J., Bruce R., Bruckman De Renstrom P., Bruna E., Bruning O., Brunner O., Brunner K., Bruzzone P., Buffat X., Bulyak E., Burkart F., Burkhardt H., Burnet J.-P., Butin F., Buttazzo D., Butterworth A., Caccia M., Cai Y., Caiffi B., Cairo V., Cakir O., Calaga R., Calatroni S., Calderini G., Calderola G., Caliskan A., Calvet D., Calviani M., Camalich J.M., Camarri P., Campanelli M., Camporesi T., Canbay A.C., Canepa A., Cantergiani E., Cantore-Cavalli D., Capeans M., Cardarelli R., Cardella U., Cardini A., Carloni Calame C.M., Carra F., Carra S., Carvalho A., Casalbuoni S., Casas J., Cascella M., Castelnovo P., Castorina G., Catalano G., Cavasinni V., Cazzato E., Cennini E., Cerri A., Cerutti F., Cervantes J., Chaikovska I., Chakrabortty J., Chala M., Chamizo-Llatas M., Chanal H., Chanal D., Chance S., Chance A., Charitos P., Charles J., Charles T.K., Chattopadhyay S., Chehab R., Chekanov S.V., Chen N., Chernoded A., Chetvertkova V., Chevalier L., Chiarelli G., Chiarello G., Chiesa M., Chiggiato P., Childers J.T., Chmielinska A., Cholakian A., Chomaz P., Chorowski M., Chou W., Chrzaszcz M., Chyhyrynets E., Cibinetto G., Ciftci A.K., Ciftci R., Cimino R., Ciuchini M., Clark P.J., Coadou Y., Cobal M., Coccaro A., Cogan J., Cogneras E., Collamati F., Colldelram C., Collier P., Collot J., Contino R., Conventi F., Cook C.T.A., Cooley L., Corcella G., Cornell A.S., Corral G.H., Correia-Rodrigues H., Costanza F., Costa Pinto P., Couderc F., Coupard J., Craig N., Crespo Garrido I., Crivellin A., Croteau J.F., Crouch M., Cruz Alaniz E., Cure B., Curti J., Curtin D., Czech M., Dachauer C., D'Agnolo R.T., Daibo M., Dainese A., Dalena B., Daljevec A., Dallapiazza W., D'Aloia Schwartzentruber L., Dam M., D'Ambrosio G., Das S.P., DasBakshi S., da Silva W., da Silveira G.G., D'Auria V., D'Auria S., David A., Davidek T., Deandrea A., de Blas J., Debono C.J., De Curtis S., De Filippis N., de Florian D., Deghaye S., de Jong S.J., Del Bo C., Del Duca V., Delikaris D., Deliot F., Dell'Acqua A., Delle Rose L., Delmastro M., De Lucia E., Demarteau M., Denegri D., Deniau L., Denisov D., Denizli H., Denner A., d'Enterria D., de Rijk G., De Roeck A., Derue F., Deschamps O., Descotes-Genon S., Dev P.S.B., de Vivie de Regie J.B., Dewanjee R.K., Di Ciaccio A., Di Cicco A., Dillon B.M., Di Micco B., Di Nezza P., Di Vita S., Doblhammer A., Dominjon A., D'Onofrio M., Dordei F., Drago A., Draper P., Drasal Z., Drewes M., Duarte L., Dubovyk I., Duda P., Dudarev A., Dudko L., Duellmann D., Dunser M., du Pree T., Durante M., Duran Yildiz H., Dutta S., Duval F., Duval J.M., Dydyshka Y., Dziewit B., Eisenhardt S., Eisterer M., Ekelof T., El Khechen D., Ellis S.A., Ellis J., Ellison J.A., Elsener K., Elsing M., Enari Y., Englert C., Eriksson H., Eskola K.J., Esposito L.S., Etisken O., Etzion E., Fabbricatore P., Falkowski A., Falou A., Faltova J., Fan J., Fano L., Farilla A., Farinelli R., Farinon S., Faroughy D.A., Fartoukh S.D., Faus-Golfe A., Fawcett W.J., Felici G., Felsberger L., Ferdeghini C., Fernandez Navarro A.M., Fernandez-Tellez A., Ferradas Troitino J., Ferrara G., Ferrari R., Ferreira L., Ferreira da Silva P., Ferrera G., Ferro F., Fiascaris M., Fiorendi S., Fiorio C., Fischer O., Fischer E., Flieger W., Florio M., Fonnesu D., Fontanesi E., Foppiani N., Foraz K., Forkel-Wirth D., Forte S., Fouaidy M., Fournier D., Fowler T., Fox J., Francavilla P., Franceschini R., Franchino S., Franco E., Freitas A., Fuks B., Furukawa K., Furuseth S.V., Gabrielli E., Gaddi A., Galanti M., Gallo E., Ganjour S., Gao J., Garcia Diaz V., Garcia Perez M., Garcia Tabares L., Garion C., Garzelli M.V., Garzia I., Gascon-Shotkin S.M., Gaudio G., Gay P., Ge S.-F., Gehrmann T., Genest M.H., Gerard R., Gerigk F., Gerwig H., Giacomelli P., Giagu S., Gianfelice-Wendt E., Gianotti F., Giffoni F., Gilardoni S.S., Gil Costa M., Giovannetti M., Giovannozzi M., Giubellino P., Giudice G.F., Giunta A., Gladilin L.K., Glukhov S., Gluza J., Gobbi G., Goddard B., Goertz F., Golling T., Goncalves V.P., Goncalo R., Gonzalez Gomez L.A., Gorgi Zadeh S., Gorine G., Gorini E., Gourlay S.A., Gouskos L., Grancagnolo F., Grassellino A., Grau A., Graverini E., Gray H.M., Greco M., Grenard J.-L., Grimm O., Grojean C., Gromov V.A., Grosse-Oetringhaus J.F., Grudiev A., Grzanka K., Gu J., Guadagnoli D., Guidi V., Guiducci S., Guillermo Canton G., Gunaydin Y.O., Gupta R., Gupta R.S., Gutierrez J., Gutleber J., Guyot C., Guzey V., Gwenlan C., Haberstroh C., Hacisahinoglu B., Haerer B., Hahn K., Hahn T., Hammad A., Han C., Hance M., Hannah A., Harris P.C., Hati C., Haug S., Hauptman J., Haurylavets V., He H.-J., Hegglin A., Hegner B., Heinemann K., Heinemeyer S., Helsens C., Henriques A., Hernandez P., Hernandez-Pinto R.J., Hernandez-Sanchez J., Herzig T., Hiekkanen I., Hillert W., Hoehn T., Hofer M., Hofle W., Holdener F., Holleis S., Holzer B., Hong D.K., Honorato C.G., Hopkins S.C., Hrdinka J., Hug F., Humann B., Humer H., Hurth T., Hutton A., Iacobucci G., Ibarrola N., Iconomidou-Fayard L., Ilyina-Brunner K., Incandela J., Infantino A., Ippolito V., Ishino M., Islam R., Ita H., Ivanovs A., Iwamoto S., Iyer A., Izquierdo Bermudez S., Jadach S., Jamin D.O., Janot P., Jarry P., Jeff A., Jenny P., Jensen E., Jensen M., Jiang X., Jimenez J.M., Jones M.A., Jones O.R., Jowett J.M., Jung S., Kaabi W., Kado M., Kahle K., Kalinovskaya L., Kalinowski J., Kamenik J.F., Kannike K., Kara S.O., Karadeniz H., Karaventzas V., Karpov I., Kartal S., Karyukhin A., Kashikhin V., Katharina Behr J., Kaya U., Keintzel J., Keinz P.A., Keppel K., Kersevan R., Kershaw K., Khanpour H., Khatibi S., Khatiri Yanehsari M., Khoze V.V., Kieseler J., Kilic A., Kilpinen A., Kim Y.-K., Kim D.W., Klein U., Klein M., Kling F., Klinkenberg N., Kloppel S., Klute M., Klyukhin V.I., Knecht M., Kniehl B., Kocak F., Koeberl C., Kolano A.M., Kollegger A., Kolodziej K., Kolomiets A.A., Komppula J., Koop I., Koppenburg P., Koratzinos M., Kordiaczynska M., Korjik M., Kortner O., Kostka P., Kotlarski W., Kotnig C., Kottig T., Kotwal A.V., Kovalenko A.D., Kowalski S., Kozaczuk J., Kozlov G.A., Kozub S.S., Krainer A.M., Kramer T., Kramer M., Krammer M., Krasnov A.A., Krauss F., Kravalis K., Kretzschmar L., Kriske R.M., Kritscher H., Krkotic P., Kroha H., Kucharczyk M., Kuday S., Kuendig A., Kuhlmann G., Kulesza A., Kumar M., Kusina A., Kuttimalai S., Kuze M., Kwon T., Lackner F., Lackner M., La Francesca E., Laine M., Lamanna G., La Mendola S., Lancon E., Landsberg G., Langacker P., Lange C., Langner A., Lankford A.J., Lansberg J.P., Lari T., Laycock P.J., Lebrun P., Lechner A., Lee K., Lee S., Lee R., Lefevre T., Le Guen P., Lehtinen T., Leith S.B., Lenzi P., Leogrande E., Leonidopoulos C., Leon-Monzon I., Lerner G., Leroy O., Lesiak T., Levai P., Leveratto A., Levichev E., Li G., Li S., Li R., Liberati D., Liepe M., Lissauer D.A., Liu Z., Lobko A., Locci E., Logothetis Agaliotis E., Lombardo M.P., Long A.J., Lorin C., Losito R., Louzguiti A., Low I., Lucchesi D., Lucchini M.T., Luciani A., Lueckhof M., Lunt A.J.G., Luzum M., Lyubimtsev D.A., Maggiora M., Magnin N., Mahmoud M.A., Mahmoudi F., Maitre J., Makarenko V., Malagoli A., Malcles J., Malgeri L., Mallon P.J., Maltoni F., Malvezzi S., Malyshev O.B., Mancinelli G., Mandrik P., Manfrinetti P., Mangano M., Manil P., Mannelli M., Marchiori G., Marhauser F., Mariani V., Marinozzi V., Mariotto S., Marquard P., Marquet C., Marriott-Dodington T., Martin R., Martin O., Martin Camalich J., Martinez T., Martinez Bruzual H., Martinez-Hernandez M.I., Martins D.E., Marzani S., Marzocca D., Marzola L., Masciocchi S., Masina I., Massimiliano A., Massironi A., Masubuchi T., Matveev V.A., Mazzoni M.A., McCullough M., McIntosh P.A., Meade P., Medina L., Meier A., Meignan J., Mele B., Mendes Saraiva J.G., Menez F., Mentink M., Meoni E., Meridiani P., Merk M., Mermod P., Mertens V., Mether L., Metral E., Migliorati M., Milanese A., Milardi C., Milhano G., Militsyn B.L., Millet F., Minashvili I., Minervini J.V., Miralles L.S., Mirarchi D., Mishima S., Missiaen D.P., Mitselmakher G., Mitshuhashi T., Mnich J., Mohammadi Najafabadi M., Mohapatra R.N., Mokhov N., Molson J.G., Monge R., Montag C., Montagna G., Monteil S., Montenero G., Montesinos E., Moortgat F., Morange N., Morello G., Moreno Llacer M., Moretti M., Moretti S., Morley A.K., Moros A., Morozov I., Morretta V., Morrone M., Mostacci A., Muanza S., Muchnoi N., Muhlegger M., Mulder M., Mulders M., Muller B., Muller F., Muller A.-S., Munilla J., Murray M.J., Muttoni Y., Myers S., Mylona M., Nachtman J., Nakamoto T., Nardecchia M., Nardini G., Nason P., Nergiz Z., Nesterenko A.V., Netto J.A., Nettstrater A., Neubuser C., Neundorf J., Niccoli F., Nicrosini O., Nie Y., Niedermayer U., Niedziela J., Niemi A., Nikitin S.A., Nisati A., No J.M., Nonis M., Nosochkov Y., Novak M., Novokhatski A., O'Callaghan J.M., Ochando C., Ogur S., Ohmi K., Oide K., Okorokov V.A., Okumura Y., Oleari C., Olness F.I., Onel Y., Ortino M., Osborne J., Osland P., Otto T., Oyulmaz K.Y., Ozansoy A., Ozcan V., Ozdemir K., Pagliarone C.E., Pais da Silva H.F., Palmieri E., Palumbo L., Pampaloni A., Pan R.-Q., Panareo M., Panella O., Panico G., Panizzo G., Pankov A.A., Pantsyrny V., Papadopoulos C.G., Papaefstathiou A., Papaphilippou Y., Parker M.A., Parma V., Pasquali M., Patra S.K., Patterson R., Paukkunen H., Pauss F., Peggs S., Penttinen J.-P., Peon G., Perepelkin E.E., Perez E., Perez J.C., Perez G., Perez F., Perez Codina E., Perez Morales J., Perfilov M., Pernegger H., Peruzzi M., Pes C., Peters K., Petracca S., Petriello F., Pezzotti L., Pfeiffer S., Piccinini F., Pieloni T., Pierini M., Pikhartova H., Pikurs G., Pilicer E., Piminov P., Pira C., Pittau R., Placzek W., Plagge M., Plehn T., Pleier M.-A., Ploskon M., Podeur M., Podlech H., Podzorny T., Poggioli L., Poiron A., Polesello G., Poli Lener M., Polini A., Polinski J., Polozov S.M., Ponce L., Pont M., Pontecorvo L., Portaluri T., Potamianos K., Prasse C., Prausa M., Preinerstorfer A., Premat E., Price T., Primavera M., Prino F., Prioli M., Proudfoot J., Provino A., Pugnat T., Pukhaeva N., Pulawski S., Pulikowski D., Punzi G., Putti M., Pyarelal A., Quack H., Quispe M., Racioppi A., Rafique H., Raginel V., Raidal M., Ramirez-Uribe N.S., Ramsey-Musolf M.J., Rata R., Ratoff P., Ravotti F., Rebello Teles P., Reboud M., Redaelli S., Renner E., Renteria-Olivo A.E., Rescigno M., Reuter J., Ribon A., Ricci A.M., Riegler W., Riemann S., Riemann B., Riemann T., Rifflet J.M., Rimmer R.A., Rinaldesi R., Rinolfi L., Rios Rubiras O., Risselada T., Rivetti A., Rivkin L., Rizzo T., Robens T., Robert F., Robson A.J., Rochepault E., Roda C., Rodrigo G., Rodriguez-Cahuantzi M., Rogan C., Roig M., Rojas-Torres S., Rojo J., Rolandi G., Rolando G., Roloff P., Romanenko A., Romanov A., Roncarolo F., Rosado Sanchez A., Rosaz G., Rossi L., Rossi A., Rossmanith R., Rousset B., Royon C., Ruan X., Ruehl I., Ruhlmann-Kleider V., Ruiz R., Rumyantsev L., Ruprecht R., Ryazanov A.I., Saba A., Sadykov R., Saez de Jauregui D., Sahin M., Sailer B., Saito M., Sala F., Salam G.P., Salfeld-Nebgen J., Salgado C.A., Salini S., Sallese J.M., Salmi T., Salzburger A., Sampayo O.A., Sanfilippo S., Santiago J., Santopinto E., Santoro R., Sanz Ull A., Sarasola X., Sarpun I.H., Sauvain M., Savelyeva S., Sawada R., Sborlini G.F.R., Schaffer A., Schaumann M., Schenk M., Scheuerlein C., Schienbein I., Schlenga K., Schmickler H., Schmidt R., Schoerling D., Schoning A., Schorner-Sadenius T., Schott M., Schulte D., Schwaller P., Schwanenberger C., Schwemling P., Schwerg N., Scibile L., Sciuto A., Scomparin E., Sebastiani C., Seeber B., Segreti M., Selva P., Selvaggi M., Senatore C., Senol A., Serin L., Serluca M., Serra N., Seryi A., Sestini L., Sfyrla A., Shaposhnikov M., Shaposhnikova E., Sharkov B.Y., Shatilov D., Shelton J., Shiltsev V., Shipsey I.P., Shirkov G.D., Shivaji A., Shwartz D., Sian T., Sidorov S., Siemko A., Silvestrini L., Simand N., Simon F., Singh B.K., Siodmok A., Sirois Y., Sirtori E., Sirvinskaite R., Sitar B., Sjostrand T., Skands P., Skordis E., Skovpen K., Skrzypek M., Slade E., Slavich P., Slovak R., Smaluk V., Smirnov V., Snoeys W., Soffi L., Sollander P., Solovyanov O., Soltveit H.K., Song H., Sopicki P., Sorbi M., Spallino L., Spannowsky M., Spataro B., Sphicas P., Spiesberger H., Spiller P., Spira M., Srivastava T., Stachel J., Stakia A., Stanyard J.L., Starchenko E., Starikov A.Y., Stasto A.M., Statera M., Steerenberg R., Steggemann J., Stenvall A., Stivanello F., Stockinger D., Stoel L.S., Stoger-Pollach M., Strauss B., Stuart M., Stupakov G., Su S., Sublet A., Sugita K., Sulak L., Sullivan M.K., Sultansoy S., Sumida T., Suzuki K., Sylva G., Syphers M.J., Sznajder A., Taborelli M., Tahir N.A., Takeuchi M., Tal Hod E., Tambasco C., Tanaka J., Tang K., Tapan I., Taroni S., Tartarelli G.F., Tassielli G., Tavian L., Taylor T.M., Taylor G.N., Teixeira A.M., Tejeda-Munoz G., Telnov V.I., Tenchini R., ten Kate H.H.J., Terashi K., Tesi A., Testa M., Tetrel C., Teytelman D., Thaler J., Thamm A., Thomas S., Tiirakari M.T., Tikhomirov V., Tikhonov D., Timko H., Tisserand V., Tkachenko L.M., Tkaczuk J., Tock J.P., Todd B., Todesco E., Tomas Garcia R., Tommasini D., Tonelli G., Toral F., Torims T., Torre R., Townsend Z., Trant R., Treille D., Trentadue L., Tricoli A., Tricomi A., Trischuk W., Tropin I.S., Tuchming B., Tudora A.A., Turbiarz B., Turk Cakir I., Turri M., Tydecks T., Usovitsch J., Uythoven J., Vaglio R., Valassi A., Valchkova F., Valdivia Garcia M.A., Valente P., Valente R.U., Valente-Feliciano A.-M., Valentino G., Vale Silva L., Valet J.M., Valizadeh R., Valle J.W.F., Vallecorsa S., Vallone G., van Leeuwen M., van Rienen U.H., van Riesen-Haupt L., Varasteh M., Vecchi L., Vedrine P., Velev G., Veness R., Ventura A., Venturini Delsolaro W., Verducci M., Verhaaren C.B., Vernieri C., Verweij A.P., Verwilligen O., Viazlo O., Vicini A., Viehhauser G., Vignaroli N., Vignolo M., Vitrano A., Vivarelli I., Vlachos S., Vogel M., Vogt D.M., Volkl V., Volkov P., Volpini G., von Ahnen J., Vorotnikov G., Voutsinas G.G., Vysotsky V., Wagner U., Wallny R., Wang L.-T., Wang R., Wang K., Ward B.F.L., Watson T.P., Watson N.K., Ws Z., Weiland C., Weinzierl S., Welsch C.P., Wenninger J., Widorski M., Wiedemann U.A., Wienands H.-U., Wilkinson G., Williams P.H., Winter A., Wohlfahrt A., Wojton T., Wollmann D., Womersley J., Woog D., Wu X., Wulzer A., Yanehsari M.K., Yang G., Yang H.J., Yao W.-M., Yazgan E., Yermolchik V., Yilmaz A., Yoo H.-D., Yost S.A., You T., Young C., Yu T.-T., Yu F., Zaborowska A., Zadeh S.G., Zahnd M., Zanetti M., Zanotto L., Zawiejski L., Zeiler P., Zerlauth M., Zernov S.M., Zevi Dell Porta G., Zhang Z., Zhang Y., Zhang C., Zhang H., Zhao Z., Zhong Y.-M., Zhou J., Zhou D., Zhuang P., Zick G., Zimmermann F., Zinn-Justin J., Zivkovic L., Zlobin A.V., Zobov M., Zupan J., Zurita J., BAİBÜ, Fen Edebiyat Fakültesi, Fizik Bölümü, Denizli, Haluk, TOBB ETU, Faculty of Engineering, Department of Electrical & Electronics Engineering, TOBB ETU, Faculty of Engineering, Department of Material Science & Nanotechnology Engineering, TOBB ETÜ, Mühendislik Fakültesi, Elektrik ve Elektronik Mühendisliği Bölümü, TOBB ETÜ, Mühendislik Fakültesi, Malzeme Bilimi ve Nanoteknoloji Mühendisliği Bölümü, Bozbey, Ali, Sultansoy, Saleh, Özdemir, Kadri, Giresun Üniversitesi, UCL - SST/IRMP - Institut de recherche en mathématique et physique, and Ege Üniversitesi

Subjects
Beam losses, IMPACT, Physics::Instrumentation and Detectors, Physics beyond the Standard Model, EVENT BUILDER, hadron collider, General Physics and Astronomy, Mathematics and natural science: 400::Physics: 430::Nuclear and elementary particle physics: 431 [VDP], 01 natural sciences, 7. Clean energy, law.invention, Subatomär fysik, chemistry.chemical_compound, Conceptual design, Colliding beam accelerators, law, HE-LHC, Subatomic Physics, General Materials Science, Hadron colliders, Física::Física de partícules::Hadrons [Àrees temàtiques de la UPC], Large Hadron Collider, Acceleradors de partícules, Physics, Settore FIS/01 - Fisica Sperimentale, Beams (radiation), Settore FIS/02 - Fisica Teorica, Modelli e Metodi Matematici, Upgrade, Impact, collimators, partikkelfysikk, Future Circular Collider, High-Energy, Systems engineering, HE-LHC: The High-Energy Large Hadron Collider, Col·lisionadors d'hadrons, Applied physics, Collimators, Socio-culturale, Fizik, Hadrons, Accelerator Physics and Instrumentation, HE-LHC physics, Condensed Matter::Materials Science, 0103 physical sciences, Physics::Atomic and Molecular Clusters, beam losses, ddc:530, High Energy Physics, partikkelakselerator, Physical and Theoretical Chemistry, Niobium-tin, 010306 general physics, Collider, Particle Physics, Beams (radiation) | Collimators | Beam losses, Energies::Energia nuclear [Àrees temàtiques de la UPC], Large Hadron Collider HE-LHC, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Colliders (Nuclear physics), Acceleratorfysik och instrumentering, Event builder, Accelerators and Storage Rings, Particle accelerators, chemistry, Experimental High Energy Physics, Physics::Accelerator Physics, High Energy Physics::Experiment, Future Colliders
Abstract

Authors: A. AbadaM. AbbresciaS. S. AbdusSalamI. AbdyukhanovJ. Abelleira FernandezA. AbramovM. AburaiaA. O. AcarP. R. AdzicP. AgrawalJ. A. Aguilar-SaavedraJ. J. Aguilera-VerdugoM. AibaI. AichingerG. AielliA. AkayA. AkhundovH. AksakalJ. L. AlbaceteS. AlbergoA. AlekouM. AleksaR. AleksanR. M. Alemany FernandezY. AlexahinR. G. AlíaS. AlioliN. Alipour TehraniB. C. AllanachP. P. AllportM. AltınlıW. AltmannshoferG. AmbrosioD. AmorimO. AmstutzL. AnderliniA. AndreazzaM. AndreiniA. AndriatisC. AndrisA. AndronicM. AngelucciF. AntinoriS. A. AntipovM. AntonelliM. AntonelloP. AntonioliS. AntuschF. AnulliL. ApolinárioG. ApollinariA. ApollonioD. AppelöR. B. ApplebyA. ApyanA. ApyanA. ArbeyA. ArbuzovG. ArduiniV. ArıS. AriasN. ArmestoR. ArnaldiS. A. ArsenyevM. ArzeoS. AsaiE. AslanidesR. W. AßmannD. AstapovychM. AtanasovS. AtiehD. AttiéB. AuchmannA. AudurierS. AullS. AumonS. AuneF. AvinoG. AvrillaudG. AydınA. AzatovG. AzuelosP. AzziO. AzzoliniP. AzzurriN. BacchettaE. BacchiocchiH. BachacouY. W. BaekV. BaglinY. BaiS. BairdM. J. BakerM. J. BaldwinA. H. BallA. BallarinoS. BanerjeeD. P. BarberD. BarducciP. BarjhouxD. BarnaG. G. BarnaföldiM. J. BarnesA. BarrJ. Barranco GarcíaJ. Barreiro Guimarães da CostaW. BartmannV. BaryshevskyE. BarziS. A. BassA. BastianinB. BaudouyF. BauerM. BauerT. BaumgartnerI. Bautista-GuzmánC. BayındırF. BeaudetteF. BedeschiM. BéguinI. BellafontL. BellagambaN. BellegardeE. BelliE. BellingeriF. BelliniG. BellomoS. BelomestnykhG. BencivenniM. BenediktG. BernardiJ. BernardiC. BernetJ. M. BernhardtC. BerniniC. BerriaudA. BertarelliS. BertolucciM. I. BesanaM. BesançonO. BeznosovP. BhatC. BhatM. E. BiaginiJ. -L. BiarrotteA. Bibet ChevalierE. R. BielertM. BigliettiG. M. BileiB. BilkiC. BiscariF. BisharaO. R. Blanco-GarcíaF. R. BlánquezF. BlekmanA. BlondelJ. BlümleinT. BoccaliR. BoelsS. A. BogaczA. BogomyagkovO. Boine-FrankenheimM. J. BolandS. BolognaO. BolukbasiM. BombenS. BondarenkoM. BonviniE. BoosB. BordiniF. BordryG. BorghelloL. BorgonoviS. BorowkaD. BortolettoD. 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GuiducciG. Guillermo CantonY. O. GünaydinR. GuptaR. S. GuptaJ. GutierrezJ. GutleberC. GuyotV. GuzeyC. GwenlanC. HaberstrohB. HacışahinoğluB. HaererK. HahnT. HahnA. HammadC. HanM. HanceA. HannahP. C. HarrisC. HatiS. HaugJ. HauptmanV. HaurylavetsH. -J. HeA. HegglinB. HegnerK. HeinemannS. HeinemeyerC. HelsensA. HenriquesA. HenriquesP. HernandezR. J. Hernández-PintoJ. Hernandez-SanchezT. HerzigI. HiekkanenW. HillertT. HoehnM. HoferW. HöfleF. HoldenerS. HolleisB. HolzerD. K. HongC. G. HonoratoS. C. HopkinsJ. HrdinkaF. HugB. HumannH. HumerT. HurthA. HuttonG. IacobucciN. IbarrolaL. Iconomidou-FayardK. Ilyina-BrunnerJ. IncandelaA. InfantinoV. IppolitoM. IshinoR. IslamH. ItaA. IvanovsS. IwamotoA. IyerS. Izquierdo BermudezS. JadachD. O. JaminP. JanotP. JarryA. JeffP. JennyE. JensenM. JensenX. JiangJ. M. JiménezM. A. JonesO. R. JonesJ. M. JowettS. JungW. KaabiM. KadoK. KahleL. KalinovskayaJ. KalinowskiJ. F. KamenikK. KannikeS. O. KaraH. KaradenizV. KaraventzasI. KarpovS. KartalA. KaryukhinV. KashikhinJ. Katharina BehrU. KayaJ. KeintzelP. A. KeinzK. KeppelR. KersevanK. KershawH. KhanpourS. KhatibiM. Khatiri YanehsariV. V. KhozeJ. KieselerA. KilicA. KilpinenY. -K. KimD. W. KimU. KleinM. KleinF. KlingN. KlinkenbergS. KlöppelM. KluteV. I. KlyukhinM. KnechtB. KniehlF. KocakC. KoeberlA. M. KolanoA. KolleggerK. KołodziejA. A. KolomietsJ. KomppulaI. KoopP. KoppenburgM. KoratzinosM. KordiaczyńskaM. KorjikO. KortnerP. KostkaW. KotlarskiC. KotnigT. KöttigA. V. KotwalA. D. KovalenkoS. KowalskiJ. KozaczukG. A. KozlovS. S. KozubA. M. KrainerT. KramerM. KrämerM. KrammerA. A. KrasnovF. KraussK. KravalisL. KretzschmarR. M. KriskeH. KritscherP. KrkoticH. KrohaM. KucharczykS. KudayA. KuendigG. KuhlmannA. KuleszaM. KumarM. KumarA. KusinaS. KuttimalaiM. KuzeT. KwonF. LacknerM. LacknerE. La FrancescaM. LaineG. LamannaS. La MendolaE. LançonG. LandsbergP. LangackerC. LangeA. LangnerA. J. LankfordJ. P. LansbergT. LariP. J. LaycockP. LebrunA. LechnerK. LeeS. LeeR. LeeT. LefevreP. Le GuenT. LehtinenS. B. LeithP. LenziE. LeograndeC. LeonidopoulosI. Leon-MonzonG. LernerO. LeroyT. LesiakP. LévaiA. LeverattoE. LevichevG. LiS. LiR. LiD. LiberatiM. LiepeD. A. LissauerZ. LiuA. LobkoE. LocciE. Logothetis AgaliotisM. P. LombardoA. J. LongC. LorinR. LositoA. LouzguitiI. LowD. LucchesiM. T. LucchiniA. LucianiM. LueckhofA. J. G. LuntM. LuzumD. A. LyubimtsevM. MaggioraN. MagninM. A. MahmoudF. MahmoudiJ. MaitreV. MakarenkoA. MalagoliJ. MalclésL. MalgeriP. J. MallonF. MaltoniS. MalvezziO. B. MalyshevG. MancinelliP. MandrikP. ManfrinettiM. ManganoP. ManilM. MannelliG. MarchioriF. MarhauserV. MarianiV. MarinozziS. MariottoP. MarquardC. MarquetT. Marriott-DodingtonR. MartinO. MartinJ. Martin CamalichT. MartinezH. Martinez BruzualM. I. Martínez-HernándezD. E. MartinsS. MarzaniD. MarzoccaL. MarzolaS. MasciocchiI. MasinaA. MassimilianoA. MassironiT. MasubuchiV. A. MatveevM. A. MazzoniM. McCulloughP. A. McIntoshP. MeadeL. MedinaA. MeierJ. MeignanB. MeleJ. G. Mendes SaraivaF. MenezM. MentinkE. MeoniP. MeridianiM. MerkP. MermodV. MertensL. MetherE. MétralM. MiglioratiA. MilaneseC. MilardiG. MilhanoB. L. MilitsynF. MilletI. MinashviliJ. V. MinerviniL. S. MirallesD. MirarchiS. MishimaD. P. MissiaenG. MitselmakherT. MitshuhashiJ. MnichM. Mohammadi NajafabadiR. N. MohapatraN. MokhovJ. G. MolsonR. MongeC. MontagG. MontagnaS. MonteilG. MonteneroE. MontesinosF. MoortgatN. MorangeG. MorelloM. Moreno LlácerM. MorettiS. MorettiA. K. MorleyA. MorosI. MorozovV. MorrettaM. MorroneA. MostacciS. MuanzaN. MuchnoiM. MühleggerM. MulderM. MuldersB. MüllerF. MüllerA. -S. MüllerJ. MunillaM. J. MurrayY. MuttoniS. MyersM. MylonaJ. NachtmanT. NakamotoM. NardecchiaG. NardiniP. NasonZ. NergizA. V. NesterenkoJ. A. NettoA. NettsträterC. NeubüserJ. NeundorfF. NiccoliO. NicrosiniY. NieU. NiedermayerJ. NiedzielaA. NiemiS. A. NikitinA. NisatiJ. M. NoM. NonisY. NosochkovM. NovákA. NovokhatskiJ. M. O’CallaghanC. OchandoS. OgurK. OhmiK. OideV. A. OkorokovY. OkumuraC. OleariF. I. OlnessY. OnelM. OrtinoJ. OsborneP. OslandT. OttoK. Y. OyulmazA. OzansoyV. ÖzcanK. ÖzdemirC. E. PagliaroneH. F. Pais da SilvaE. PalmieriL. PalumboA. PampaloniR. -Q. PanM. PanareoO. PanellaG. PanicoG. PanizzoA. A. PankovV. PantsyrnyC. G. PapadopoulosA. PapaefstathiouY. PapaphilippouM. A. ParkerV. ParmaM. PasqualiS. K. PatraR. PattersonH. PaukkunenF. PaussS. PeggsJ. -P. PenttinenG. PeónE. E. PerepelkinE. PerezJ. C. PerezG. PerezF. PérezE. Perez CodinaJ. Perez MoralesM. PerfilovH. PerneggerM. PeruzziC. PesK. PetersS. PetraccaF. PetrielloL. PezzottiS. PfeifferF. PiccininiT. PieloniM. PieriniH. PikhartovaG. PikursE. PilicerP. PiminovC. PiraR. PittauW. PłaczekM. PlaggeT. PlehnM. -A. PleierM. PłoskońM. PodeurH. PodlechT. PodzornyL. PoggioliA. PoironG. PoleselloM. Poli LenerA. PoliniJ. PolinskiS. M. PolozovL. PonceM. PontL. PontecorvoT. PortaluriK. PotamianosC. PrasseM. PrausaA. PreinerstorferE. PrematT. PriceM. PrimaveraF. PrinoM. PrioliJ. ProudfootA. ProvinoT. PugnatN. PukhaevaS. PuławskiD. PulikowskiG. PunziM. PuttiA. PyarelalH. QuackM. QuispeA. RacioppiH. RafiqueV. RaginelM. RaidalN. S. Ramírez-UribeM. J. Ramsey-MusolfR. RataP. RatoffF. RavottiP. Rebello TelesM. ReboudS. RedaelliE. RennerA. E. Rentería-OlivoM. RescignoJ. ReuterA. RibonA. M. RicciW. RieglerS. RiemannB. RiemannT. RiemannJ. M. RiffletR. A. RimmerR. RinaldesiL. RinolfiO. Rios RubirasT. RisseladaA. RivettiL. RivkinT. RizzoT. RobensF. RobertA. J. RobsonE. RochepaultC. RodaG. RodrigoM. Rodríguez-CahuantziC. RoganM. RoigS. Rojas-TorresJ. RojoG. RolandiG. RolandoP. RoloffA. RomanenkoA. RomanovF. RoncaroloA. Rosado SanchezG. RosazL. RossiA. RossiR. RossmanithB. RoussetC. RoyonX. RuanI. RuehlV. Ruhlmann-KleiderR. RuizL. RumyantsevR. RuprechtA. I. RyazanovA. SabaR. SadykovD. Saez de JaureguiM. SahinB. SailerM. SaitoF. SalaG. P. SalamJ. Salfeld-NebgenC. A. SalgadoS. SaliniJ. M. SalleseT. SalmiA. SalzburgerO. A. SampayoS. SanfilippoJ. SantiagoE. SantopintoR. SantoroA. Sanz UllX. SarasolaI. H. SarpünM. SauvainS. SavelyevaR. SawadaG. F. R. SborliniA. SchafferM. SchaumannM. SchenkC. ScheuerleinI. SchienbeinK. SchlengaH. SchmicklerR. SchmidtD. SchoerlingA. SchoningT. Schörner-SadeniusM. SchottD. SchulteP. SchwallerC. SchwanenbergerP. SchwemlingN. SchwergL. ScibileA. SciutoE. ScomparinC. SebastianiB. SeeberM. SegretiP. SelvaM. SelvaggiC. SenatoreA. SenolL. SerinM. SerlucaN. SerraA. SeryiL. SestiniA. SfyrlaM. ShaposhnikovE. ShaposhnikovaB. Y. SharkovD. ShatilovJ. SheltonV. ShiltsevI. P. ShipseyG. D. ShirkovA. ShivajiD. ShwartzT. SianS. SidorovA. SiemkoL. SilvestriniN. SimandF. SimonB. K. SinghA. SiódmokY. SiroisE. SirtoriR. SirvinskaiteB. SitarT. SjöstrandP. SkandsE. SkordisK. SkovpenM. SkrzypekE. SladeP. SlavichR. SlovakV. SmalukV. SmirnovW. SnoeysL. SoffiP. SollanderO. SolovyanovH. K. SoltveitH. SongP. SopickiM. SorbiL. SpallinoM. SpannowskyB. SpataroP. SphicasH. SpiesbergerP. SpillerM. SpiraT. SrivastavaJ. StachelA. StakiaJ. L. StanyardE. StarchenkoA. Y. StarikovA. M. StaśtoM. StateraR. SteerenbergJ. SteggemannA. StenvallF. StivanelloD. StöckingerL. S. StoelM. Stöger-PollachB. StraussM. StuartG. StupakovS. SuA. SubletK. SugitaL. SulakM. K. SullivanS. SultansoyT. SumidaK. SuzukiG. SylvaM. J. SyphersA. SznajderM. TaborelliN. A. TahirM. TakeuchiE. Tal HodC. TambascoJ. TanakaK. TangI. TapanS. TaroniG. F. TartarelliG. TassielliL. TavianT. M. TaylorG. N. TaylorA. M. TeixeiraG. Tejeda-MuñozV. I. TelnovR. TenchiniH. H. J. ten KateK. TerashiA. TesiM. TestaC. TetrelD. TeytelmanJ. ThalerA. ThammS. ThomasM. T. TiirakariV. TikhomirovD. TikhonovH. TimkoV. TisserandL. M. TkachenkoJ. TkaczukJ. P. TockB. ToddE. TodescoR. Tomás GarciaD. TommasiniG. TonelliF. ToralT. TorimsR. TorreZ. TownsendR. TrantD. TreilleL. TrentadueA. TricoliA. TricomiW. TrischukI. S. TropinB. TuchmingA. A. TudoraB. TurbiarzI. Turk CakirM. TurriT. TydecksJ. UsovitschJ. UythovenR. VaglioA. ValassiF. ValchkovaM. A. Valdivia GarciaP. ValenteR. U. ValenteA. -M. Valente-FelicianoG. ValentinoL. Vale SilvaJ. M. ValetR. ValizadehJ. W. F. ValleS. VallecorsaG. ValloneM. van LeeuwenU. H. van RienenL. van Riesen-HauptM. VarastehL. VecchiP. VedrineG. VelevR. VenessA. VenturaW. Venturini DelsolaroM. VerducciC. B. VerhaarenC. VernieriA. P. VerweijO. VerwilligenO. ViazloA. ViciniG. ViehhauserN. VignaroliM. VignoloA. VitranoI. VivarelliS. VlachosM. VogelD. M. VogtV. VölklP. VolkovG. VolpiniJ. von AhnenG. VorotnikovG. G. VoutsinasV. VysotskyU. WagnerR. WallnyL. -T. WangR. WangK. WangB. F. L. WardT. P. WatsonN. K. WatsonZ. WsC. WeilandS. WeinzierlC. P. WelschJ. WenningerM. WidorskiU. A. WiedemannH. -U. WienandsG. WilkinsonP. H. WilliamsA. WinterA. WohlfahrtT. WojtońD. WollmannJ. WomersleyD. WoogX. WuA. WulzerM. K. YanehsariG. YangH. J. YangW. -M. YaoE. YazganV. YermolchikA. YilmazA. YilmazH. -D. YooS. A. YostT. YouC. YoungT. -T. YuF. YuA. ZaborowskaS. G. ZadehM. ZahndM. ZanettiL. ZanottoL. ZawiejskiP. ZeilerM. ZerlauthS. M. ZernovG. Zevi Dell PortaZ. ZhangY. ZhangC. ZhangH. ZhangZ. ZhaoY. -M. ZhongJ. ZhouD. ZhouP. ZhuangG. ZickF. ZimmermannEmail authorJ. Zinn-JustinL. ZivkovicA. V. ZlobinM. ZobovJ. ZupanJ. Zuritathe FCC Collaboration, In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the fourth volume of the FCC Conceptual Design Report, devoted to the High-Energy Large Hadron Collider HE-LHC. It summarizes the HE-LHC physics discovery opportunities, presents the HE-LHC accelerator design, performance reach, and operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the HE-LHC design aims at a hadron collider with about twice the centre-of-mass collision energy that the LHC can reach. Its performance aims at exploring physics beyond the Standard Model, signi cantly extending the LHC's direct and indirect sensitivity to new physics and discoveries.

Published
2020
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8. Prospective Lymphedema Surveillance in a Clinic Setting

Author

Rebecca Ewing, Maggie Van Loo, Bob R. Stewart, Jane M. Armer, Blake Anderson, Janet S. Chance-Hetzler, and Robin Harris

Subjects
medicine.medical_specialty, Pediatrics, Referral, Medicine (miscellaneous), lcsh:Medicine, Article, Breast cancer, cost, medicine, Retrospective analysis, Prospective cohort study, skin and connective tissue diseases, Potential impact, business.industry, lcsh:R, lymphedema, medicine.disease, humanities, Cost savings, Surgery, body regions, Lymphedema, Lower threshold, surveillance, referral, business
Abstract

The potential impact of breast cancer-related lymphedema (LE) is quite extensive, yet it often remains under-diagnosed until the later stages. This project examines the effectiveness of prospective surveillance in post-surgical breast cancer patients. A retrospective analysis of 49 out of 100 patients enrolled in a longitudinal prospective study at a Midwestern breast center evaluates: (1) time required for completion of bilateral limb measurements and Lymphedema Breast Cancer Questionnaire (LBCQ), (2) referral to LE management with limb volume increase (LVI) and/or LBCQ symptoms, and (3) cost of LE management at lower LVI (≥5%–≤10%) versus traditional (≥10%). Findings revealed a visit timeframe mean of 40.3 min (range = 25–60), 43.6% of visits were ≤30-min timeframe. Visit and measurement times decreased as clinic staff gained measurement experience, measurement time mean was 17.9 min (range = 16.9–18.9). LBCQ symptoms and LVI were significantly (p &lt, 0.001) correlated to LE referral, six of the nine patients referred (67%) displayed both LBCQ symptoms/LVI. Visits with no symptoms reported did not result in referral, demonstrating the importance of using both indicators when assessing early LE. Lower threshold referral provides compelling evidence of potential cost savings over traditional threshold referral with reported costs of: $3755.00 and $6353.00, respectively (40.9% savings).

Published
2015
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9. Control of timing, rate and bursts of hippocampal place cells by dendritic and somatic inhibition

Author

Frances S. Chance, Boris V. Zemelman, Jeffrey C. Magee, Jinhyun Kim, Sébastien Royer, Attila Losonczy, and György Buzsáki

Subjects
Optics and Photonics, Patch-Clamp Techniques, Time Factors, Interneuron, Light, Movement, Green Fluorescent Proteins, Biophysics, Action Potentials, Mice, Transgenic, Biology, Hippocampal formation, Optogenetics, Inhibitory postsynaptic potential, Hippocampus, Article, Bursting, Mice, medicine, Gene silencing, Animals, Humans, Patch clamp, Probability, Neurons, Behavior, Animal, General Neuroscience, musculoskeletal, neural, and ocular physiology, Spectrum Analysis, Neural Inhibition, Dendrites, Electric Stimulation, Mice, Inbred C57BL, medicine.anatomical_structure, Parvalbumins, nervous system, Touch, Time Perception, biology.protein, Exercise Test, Halorhodopsins, Somatostatin, Neuroscience, Parvalbumin, Photic Stimulation
Abstract

A consortium of inhibitory neurons control the firing patterns of pyramidal cells, but their specific roles in the behaving animal are largely unknown. We performed simultaneous physiological recordings and optogenetic silencing of either perisomatic (parvalbumin (PV) expressing) or dendrite-targeting (somatostatin (SOM) expressing) interneurons in hippocampal area CA1 of head-fixed mice actively moving a treadmill belt rich with visual-tactile stimuli. Silencing of either PV or SOM interneurons increased the firing rates of pyramidal cells selectively in their place fields, with PV and SOM interneurons having their largest effect during the rising and decaying parts of the place field, respectively. SOM interneuron silencing powerfully increased burst firing without altering the theta phase of spikes. In contrast, PV interneuron silencing had no effect on burst firing, but instead shifted the spikes’ theta phase toward the trough of theta. These findings indicate that perisomatic and dendritic inhibition have distinct roles in controlling the rate, burst and timing of hippocampal pyramidal cells.

Published
2012

10. Comprehensive control of resistive wall modes in DIII-D advanced tokamak plasmas

Author

Ming-Sheng Chu, T.C. Luce, R.J. La Haye, H. Reimerdes, Gerald Navratil, R. Hatcher, Yueqiang Liu, Piero Martin, E. J. Strait, M. Okabayashi, J.S. Kim, T. Bolzonella, A.M. Garofalo, M. S. Chance, G.L. Jackson, L. Marrelli, J. Manickam, M.J. Lanctot, I. N. Bogatu, A.S. Welander, R.V. Budny, Yongkyoon In, and H. Takahashi

Subjects
Physics, Nuclear and High Energy Physics, Resistive touchscreen, Tokamak, DIII-D, Cyclotron, Magnetic confinement fusion, Mechanics, Plasma, Condensed Matter Physics, law.invention, law, Beta (plasma physics), Magnetohydrodynamics, Atomic physics, HIGH-BETA, FEEDBACK STABILIZATION, TEARING MODE, STABILITY, CONFINEMENT, COILS
Abstract

The resistive wall mode (RWM) and neoclassical tearing mode (NTM) have been simultaneously suppressed in the DIII-D for durations of over 2 s at beta values 20% above the no-wall limit with modest electron cyclotron current drive and very low plasma rotation. The achieved plasma rotation was significantly lower than reported previously. However, in this regime where stable operation is obtained, it is not unconditionally guaranteed. Various MHD activities, such as edge localized modes (ELMs) and fishbones, begin to couple to the RWM branch near the no-wall limit; feedback has been useful in improving the discharge stability to such perturbations. Simultaneous operation of slow dynamic error field correction and fast feedback suppressed the pile-up of ELM-induced RWM at a series of ELM events. This result implies that successful feedback operation requires not only direct feedback against unstable RWM but also careful control of MHD-induced RWM aftermath, which is the dynamical response to a small-uncorrected error field near the no-wall beta limit. These findings are extremely useful in defining the challenge of control of the RWM and NTM in the unexplored physics territory of burning plasmas in ITER.

Published
2009
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11. Transient Responses to Rapid Changes in Mean and Variance in Spiking Models

Author

Peyman Khorsand and Frances S. Chance

Subjects
Population, Models, Neurological, lcsh:Medicine, Action Potentials, Signal, Membrane Potentials, medicine, Medicine and Health Sciences, Animals, Neuroscience/Theoretical Neuroscience, lcsh:Science, education, Physics, Neurons, education.field_of_study, Multidisciplinary, Quantitative Biology::Neurons and Cognition, Noise (signal processing), lcsh:R, Electric Conductivity, Computational Biology, Life Sciences, Function (mathematics), Electrophysiology, medicine.anatomical_structure, Step function, lcsh:Q, Neuron, Biological system, Constant (mathematics), Research Article, Neuroscience
Abstract

The mean input and variance of the total synaptic input to a neuron can vary independently, suggesting two distinct information channels. Here we examine the impact of rapidly varying signals, delivered via these two information conduits, on the temporal dynamics of neuronal firing rate responses. We examine the responses of model neurons to step functions in either the mean or the variance of the input current. Our results show that the temporal dynamics governing response onset depends on the choice of model. Specifically, the existence of a hard threshold introduces an instantaneous component into the response onset of a leaky-integrate-and-fire model that is not present in other models studied here. Other response features, for example a decaying oscillatory approach to a new steady-state firing rate, appear to be more universal among neuronal models. The decay time constant of this approach is a power-law function of noise magnitude over a wide range of input parameters. Understanding how specific model properties underlie these response features is important for understanding how neurons will respond to rapidly varying signals, as the temporal dynamics of the response onset and response decay to new steady-state determine what range of signal frequencies a population of neurons can respond to and faithfully encode.

Published
2008

12. Different weightings of input components to hippocampal CA1 place cells in young and aged rats

Author

Sara N. Burke, Andrew P. Maurer, Frances S. Chance, and Carol A. Barnes

Subjects
0303 health sciences, Theta rhythm, Perforant Pathway, Computer science, musculoskeletal, neural, and ocular physiology, General Neuroscience, Hippocampal formation, Entorhinal cortex, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, medicine.anatomical_structure, nervous system, Schaffer collateral, Poster Presentation, medicine, 10. No inequality, Neuroscience, 030217 neurology & neurosurgery, Aged rat, 030304 developmental biology
Abstract

Hippocampal place cells vary both their firing rate and also the timing of their action potentials relative to the theta rhythm as an animal moves through space, suggesting that these neurons utilize both these features to encode spatial information. Place cells within the CA1 subfield receive synaptic input from CA3 (via the Schaffer collateral pathway) and also EC3 (layer 3 of entorhinal cortex via the perforant pathway). These pathways are thought to carry different modalities of information, for example auto-associative memories from CA3 and more sensory-driven information from entorhinal cortex. We seek to understand how both modalities of information are represented in the spiking outputs of CA1 place cells. One model of CA1 phase precession [1] has proposed that these two input components drive CA1 spiking over spatially-offset but overlapping ranges of positions, and also over different ranges of theta phases. Because CA3 and EC3 inputs drive spiking at different theta phases in this model, changes in relative input strengths can be quantified by examining spike theta-phase distributions. For example, when one input component dominates CA1 spiking, the result is a unimodal theta-phase distribution, but if both input components drive CA1 spiking, their different theta-phase ranges produce a more bimodal theta-phase distribution. In this study, we examine the spike patterns of CA1 place cells recorded from young and aged rats. Aged rat brains show a decreased number of functional synapses from CA3 to CA1 pyramidal cells compared to brains from younger rats (for review, see [2,3]). This suggests that theta-phase distributions of CA1 place-cell spiking will change with aging. We find that place cells from aged rats are more strongly theta-modulated, suggesting that CA3 input plays an important role in either driving or facilitating a second spiking component of CA1 activity.

Published
2015

13. Synaptic Depression and the Temporal Response Characteristics of V1 Cells

Author

Larry F. Abbott, Frances S. Chance, and Sacha B. Nelson

Subjects
Neurons, Time Factors, Quantitative Biology::Neurons and Cognition, General Neuroscience, Response characteristics, Models, Neurological, Phase (waves), Cortical neurons, Simple cell, Summation, Adaptation, Physiological, Cutoff frequency, Article, Contrast Sensitivity, Nonlinear system, medicine.anatomical_structure, Synapses, medicine, Animals, Humans, Transient (oscillation), Psychology, Neuroscience, Visual Cortex
Abstract

We explore the effects of short-term synaptic depression on the temporal dynamics of V1 responses to visual images by constructing a model simple cell. Synaptic depression is modeled on the basis of previous detailed fits to experimental data. A component of synaptic depression operating in the range of hundreds of milliseconds can account for a number of the unique temporal characteristics of cortical neurons, including the bandpass nature of frequency-response curves, increases in response amplitude and in cutoff frequency for transient stimuli, nonlinear temporal summation, and contrast-dependent shifts in response phase. Synaptic depression also provides a mechanism for generating the temporal phase shifts needed to produce direction selectivity, and a model constructed along these lines matches both extracellular and intracellular data. A slower component of depression can reproduce the effects of contrast adaptation.

Published
1998

14. “Click”-Based Covalent Layer-by-Layer Assembly on Polyethylene Using Water-Soluble Polymeric Reagents.

Author

David E. Bergbreiter and Brandon S. Chance

Subjects
*COPPER, *POLYMERS, *NITROGEN compounds, *SPECTRUM analysis
Abstract

The use of copper(I)-catalyzed “click” reactions of azides and alkynes for covalent layer-by-layer grafting on polyethylene is described. Water-soluble poly(N-alkylacrylamide) copolymers that contain pendant azide or alkyne groups that can be thermally separated from aqueous solutions were used to alternately “click” together azide and alkyne polymers via 1,2,3-triazole formation onto a prefunctionalized alkyne-containing surface. The layer-by-layer self-assembly process proceeds under ambient conditions and was followed by ATR-IR spectroscopy using control reactions to show that azide groups and copper catalysis are required for the assembly process. Post-graft functionalization of the hyperbranched assembly is used to demonstrate that the functional interfaces so formed can be further derivatized for other functions. [ABSTRACT FROM AUTHOR]

Published
2007
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15. Receiver Operating Characteristic (ROC) Analysis for Characterizing Synaptic Efficacy.

Author

Frances S. Chance

Subjects
*NEURONS, *NEURAL circuitry, *MICROBIAL sensitivity tests, *NERVOUS system
Abstract

The role of background synaptic activity in cortical processing has recently received much attention. How do individual neurons extract information when embedded in a noisy background? When examining the impact of a synaptic input on postsynaptic firing, it is important to distinguish a change in overall firing probability from a true change in neuronal sensitivity to a particular input (synaptic efficacy) that corresponds to a change in detection performance. Here we study the impact of background synaptic input on neuronal sensitivity to individual synaptic inputs using receiver operating characteristic (ROC) analysis. We use the area under the ROC curve as a measure of synaptic efficacy, here defined as the ability of a postsynaptic action potential to identify a particular synaptic input event. An advantage of using ROC analysis to measure synaptic efficacy is that it provides a measure that is independent of postsynaptic firing rate. Furthermore, changes in mean excitation or inhibition, although affecting overall firing probability, do not modulate synaptic efficacy when measured in this way. Changes in overall conductance also affect firing probability but not this form of synaptic efficacy. Input noise, here defined as the variance of the input current, does modulate synaptic efficacy, however. This effect persists when the change in input variance is coupled with a change in conductance (as would result from changing background activity). [ABSTRACT FROM AUTHOR]

Published
2007
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16. Intracortical diffusion tensor imaging signature of microstructural changes in frontotemporal lobar degeneration.

Author

Torso M, Ridgway GR, Jenkinson M, and Chance S

Subjects
Brain, Diffusion Tensor Imaging, Humans, Frontotemporal Dementia diagnostic imaging, Frontotemporal Lobar Degeneration diagnostic imaging, Supranuclear Palsy, Progressive diagnostic imaging
Abstract

Background: Frontotemporal lobar degeneration (FTLD) is a neuropathological construct with multiple clinical presentations, including the behavioural variant of frontotemporal dementia (bvFTD), primary progressive aphasia-both non-fluent variant (nfvPPA) and semantic variant (svPPA)-progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS), characterised by the deposition of abnormal tau protein in the brain. A major challenge for treating FTLD is early diagnosis and accurate discrimination among different syndromes. The main goal here was to investigate the cortical architecture of FTLD syndromes using cortical diffusion tensor imaging (DTI) analysis and to test its power to discriminate between different clinical presentations., Methods: A total of 271 individuals were included in the study: 87 healthy subjects (HS), 31 semantic variant primary progressive aphasia (svPPA), 37 behavioural variant (bvFTD), 30 non-fluent/agrammatic variant primary progressive aphasia (nfvPPA), 47 PSP Richardson's syndrome (PSP-RS) and 39 CBS cases. 3T MRI T1-weighted images and DTI scans were analysed to extract three cortical DTI derived measures (AngleR, PerpPD and ParlPD) and mean diffusivity (MD), as well as standard volumetric measurements. Whole brain and regional data were extracted. Linear discriminant analysis was used to assess the group discrimination capability of volumetric and DTI measures to differentiate the FTLD syndromes. In addition, in order to further investigate differential diagnosis in CBS and PSP-RS, a subgroup of subjects with autopsy confirmation in the training cohort was used to select features which were then tested in the test cohort. Three different challenges were explored: a binary classification (controls vs all patients), a multiclass classification (HS vs bvFTD vs svPPA vs nfvPPA vs CBS vs PSP-RS) and an additional binary classification to differentiate CBS and PSP-RS using features selected in an autopsy confirmed subcohort., Results: Linear discriminant analysis revealed that PerpPD was the best feature to distinguish between controls and all patients (ACC 86%). PerpPD regional values were able to classify correctly the different FTLD syndromes with an accuracy of 85.6%. The PerpPD and volumetric values selected to differentiate CBS and PSP-RS patients showed a classification accuracy of 85.2%., Conclusions: (I) PerpPD achieved the highest classification power for differentiating healthy controls and FTLD syndromes and FTLD syndromes among themselves. (II) PerpPD regional values could provide an additional marker to differentiate FTD, PSP-RS and CBS., (© 2021. The Author(s).)

Published
2021
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17. Assessing the Effects of Observational Conditioning and Response-Contingent Pairing on the Vocalizations of Children With Autism Spectrum Disorder.

Author

Chance S, Cividini-Motta C, and Livingston C

Abstract

Children with autism spectrum disorder (ASD) often display impairments in communication, such as limited echoic behavior, few vocal-verbal responses, and a lack of functional communication. One potential way to foster the acquisition of vocal responses in individuals with disabilities is by conditioning vocalizations as reinforcers. Conditioning procedures include stimulus-stimulus pairing, response-contingent pairing (RCP), operant discrimination training, and observational conditioning (OC). However, previous research has not evaluated whether OC can be used to condition vocalizations as reinforcers. The current study assessed whether two conditioning procedures, RCP and OC, were effective in conditioning vocalizations as a reinforcer and also evaluated their effect on the rate of vocalizations. Participants included three children with ASD, ages 5-10 years old. During the conditioning phase, rates of vocalizations during the RCP and OC conditions and a control condition were compared within an adapted alternating-treatments design. Reinforcer assessments were completed in a multielement design, pre- and postconditioning, to assess whether the target vocalizations acquired reinforcing properties. A conditioning effect and an increase in the rate of vocalizations were observed for two of the three participants; however, the conditioning effect was minor for one participant. Overall, the results of this study indicate both the RCP and OC procedures may be beneficial in increasing vocalizations for some children and could be incorporated into clinical programs and further explored in future research., Competing Interests: Conflict of interestThe authors declare that they have no conflict of interest., (© Association for Behavior Analysis International 2021.)

Published
2021
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18. Cortical diffusivity investigation in posterior cortical atrophy and typical Alzheimer's disease.

Author

Torso M, Ahmed S, Butler C, Zamboni G, Jenkinson M, and Chance S

Subjects
Aged, Atrophy pathology, Cerebral Cortex diagnostic imaging, Cerebral Cortex pathology, Diffusion Tensor Imaging, Humans, Magnetic Resonance Imaging, Alzheimer Disease diagnostic imaging, Alzheimer Disease pathology
Abstract

Objectives: To investigate the global cortical and regional quantitative features of cortical neural architecture in the brains of patients with posterior cortical atrophy (PCA) and typical Alzheimer's disease (tAD) compared with elderly healthy controls (HC)., Methods: A novel diffusion MRI method, that has been shown to correlate with minicolumnar organization changes in the cerebral cortex, was used as a surrogate of neuropathological changes in dementia. A cohort of 15 PCA patients, 23 tAD and 22 healthy elderly controls (HC) were enrolled to investigate the changes in cortical diffusivity among groups. For each subject, 3 T MRI T1-weighted images and diffusion tensor imaging (DTI) scans were analysed to extract novel cortical DTI derived measures (AngleR, PerpPD and ParlPD). Receiver operating characteristics (ROC) curve analysis and the area under the curve (AUC) were used to assess the group discrimination capability of the method., Results: The results showed that the global cortical DTI derived measures were able to detect differences, in both PCA and tAD patients compared to healthy controls. The AngleR was the best measure to discriminate HC from tAD (AUC = 0.922), while PerpPD was the best measure to discriminate HC from PCA (AUC = 0.961). Finally, the best global measure to differentiate the two patient groups was ParlPD (AUC = 0.771). The comparison between PCA and tAD patients revealed a different pattern of damage within the AD spectrum and the regional comparisons identified significant differences in key regions including parietal and temporal lobe cortical areas. The best AUCs were shown by PerpPD right lingual cortex (AUC = 0.856), PerpPD right superior parietal cortex (AUC = 0.842) and ParlPD right lateral occipital cortex (AUC = 0.826)., Conclusions: Diagnostic group differences were found, suggesting that the new cortical DTI analysis method may be useful to investigate cortical changes in dementia, providing better characterization of neurodegeneration, and potentially aiding differential diagnosis and prognostic accuracy.

Published
2021
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19. Autism BrainNet: A network of postmortem brain banks established to facilitate autism research.

Author

Amaral DG, Anderson MP, Ansorge O, Chance S, Hare C, Hof PR, Miller M, Nagakura I, Pickett J, Schumann C, and Tamminga C

Subjects
Diagnosis, Humans, Tissue Banks supply & distribution, Autistic Disorder diagnosis, Autistic Disorder pathology, Autistic Disorder therapy, Biomedical Research methods, Brain pathology, Information Systems, Tissue Banks trends
Abstract

Autism spectrum disorder (ASD or autism) is a neurodevelopmental condition that affects over 1% of the population worldwide. Developing effective preventions and treatments for autism will depend on understanding the genetic perturbations and underlying neuropathology of the disorder. While evidence from magnetic resonance imaging and other noninvasive techniques points to altered development and organization of the autistic brain, these tools lack the resolution for identifying the cellular and molecular underpinnings of the disorder. Postmortem studies of high-quality human brain tissue currently represent the only viable option to pursuing these types of studies. However, the availability of high-quality ASD brain tissue has been extremely limited. Here we describe the establishment of a privately funded tissue bank, Autism BrainNet, a network of brain collection sites that work in a coordinated fashion to develop an adequate library of human postmortem brain tissues. Autism BrainNet was initiated as a collaboration between the Simons Foundation and Autism Speaks, and is currently funded by the Simons Foundation Autism Research Initiative. Autism BrainNet has collection sites (nodes) in California, Texas, New York, and Massachusetts; an affiliated, international node is located in Oxford, England. All donations to this network become part of a consolidated pool of tissue that is distributed to qualified investigators worldwide to carry out autism research. An essential component of this program is a widespread outreach program that highlights the need for postmortem brain donations to families affected by autism, led by the Autism Science Foundation. Challenges include an outreach campaign that deals with a disorder beginning in early childhood, collecting an adequate number of donations to deal with the high level of biologic heterogeneity of autism, and preparing this limited resource for optimal distribution to the greatest number of investigators., (Copyright © 2018 Elsevier B.V. All rights reserved.)

Published
2018
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20. Cerebral amyloid angiopathy, subcortical white matter disease and dementia: literature review and study in OPTIMA.

Author

Esiri M, Chance S, Joachim C, Warden D, Smallwood A, Sloan C, Christie S, Wilcock G, and Smith AD

Subjects
Aged, Aged, 80 and over, Animals, Apolipoproteins E genetics, Cerebral Amyloid Angiopathy complications, Cerebral Amyloid Angiopathy epidemiology, Cerebral Amyloid Angiopathy genetics, Dementia complications, Dementia epidemiology, Dementia therapy, Female, Humans, Leukoencephalopathies genetics, Longitudinal Studies, Male, Brain pathology, Cerebral Amyloid Angiopathy pathology, Dementia genetics, Dementia pathology, Leukoencephalopathies pathology
Abstract

Cerebral amyloid angiopathy (CAA) is of increasing clinical and research interest as the ability to detect it and its consequences by neuroimaging in living subjects has advanced. There is also increasing interest in understanding its possible role in the development of intracerebral hemorrhage, Alzheimer's disease (AD) and vascular dementia. In this article, the literature on this subject is reviewed and novel findings relating CAA to subcortical white matter damage in 224 subjects in the Oxford project to Investigate Memory and Ageing (OPTIMA) are reported. The relationship between CAA and subcortical tissue damage in the OPTIMA subjects was found to be critically dependent on ApoE genotype, there being a positive relationship between measures of CAA and subcortical small vessel disease in ApoEε4 carriers and a significant negative relationship in ApoEε2 carriers. These findings draw attention, as have many other studies, to the importance of ApoE genotype as a major risk factor not only for dementia but also for damage to blood vessels in the aging brain., (© 2014 International Society of Neuropathology.)

Published
2015
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21. Summary of the 1st Schizophrenia International Research Society Conference oral sessions, Venice, Italy, June 21-25, 2008: the rapporteur reports.

Author

Abubaker R, Alaerts M, Allman AA, Barnett J, Belujon P, Bittner RA, Burne TH, Cahn W, Chance S, Cherkerzian S, deSouza R, Di Forti M, du Bois T, Fatjó-Vilas M, Green M, Halperin D, John JP, Kemp A, Koelkebeck K, Lee J, Lodge DJ, Michalopoulou P, Mompremier L, Nelson B, Perälä J, Rotarska-Jagiela A, Schoeman R, Thakkar KN, Valuri G, Varambally S, Zai C, and DeLisi LE

Subjects
Humans, Italy, Societies, Medical, Congresses as Topic, Schizophrenia
Abstract

The Schizophrenia International Research Society held its first scientific conference in Venice, Italy, June 21 to 25th, 2008. A wide range of controversial topics were presented in overlapping and plenary oral sessions. These included new genetic studies, controversies about early detection of schizophrenia and the prodrome, treatment issues, clinical characteristics, cognition, neuropathology and neurophysiology, other etiological considerations, substance abuse co-morbidity, and animal models for investigating disease etiology and for use as targets in drug studies. Young investigators in the field were awarded travel grants to participate in the congress and one of their roles was to summarize the oral sessions and subsequent discussions. The reports that follow are the culmination of this work produced by 30 young investigators who attended the congress. It is hoped that these summaries will be useful synopses of what actually occurred at the congress for those who did not attend each session or were unable to be present. The abstracts of all presentations, as submitted by the authors a few months prior, were previously published as supplement 2 to volume 102/1-3, June 2008.

Published
2008
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23. Decisions and the evolution of memory: multiple systems, multiple functions.

Author

Klein SB, Cosmides L, Tooby J, and Chance S

Subjects
Humans, Task Performance and Analysis, Biological Evolution, Decision Making, Memory, Models, Theoretical
Abstract

Memory evolved to supply useful, timely information to the organism's decision-making systems. Therefore, decision rules, multiple memory systems, and the search engines that link them should have coevolved to mesh in a coadapted, functionally interlocking way. This adaptationist perspective suggested the scope hypothesis: When a generalization is retrieved from semantic memory, episodic memories that are inconsistent with it should be retrieved in tandem to place boundary conditions on the scope of the generalization. Using a priming paradigm and a decision task involving person memory, the authors tested and confirmed this hypothesis. The results support the view that priming is an evolved adaptation. They further show that dissociations between memory systems are not--and should not be--absolute: Independence exists for some tasks but not others.

Published
2002
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24. Risk factors for suicide attempts among African American women.

Author

Kaslow N, Thompson M, Meadows L, Chance S, Puett R, Hollins L, Jessee S, and Kellermann A

Subjects
Adaptation, Psychological, Adult, Case-Control Studies, Educational Status, Female, Ill-Housed Persons, Humans, Interpersonal Relations, Marital Status, Middle Aged, Models, Psychological, Multivariate Analysis, Risk Factors, Social Support, Spouse Abuse, Stress, Psychological complications, Substance-Related Disorders complications, Unemployment, United States epidemiology, Black or African American psychology, Suicide, Attempted ethnology, Suicide, Attempted psychology, Women psychology
Abstract

The aim of this study was to examine psychological and interpersonal risk factors for suicidal behavior in low income, African American women; 285 African American women who reported being in a relationship with a partner in the past year were studied, 148 presented to the hospital following a suicide attempt, and 137 presented for general medical care. Cases were compared to controls with respect to psychological symptoms, alcohol and drug abuse, family violence (intimate partner abuse, childhood trauma), relationship discord, and social support. Psychological risk factors for suicide attempts at the univariate level included psychological distress [Crude Odds Ratio (COR) = 6.5], post traumatic stress disorder (PTSD) symptoms (COR = 3.8), hopelessness (COR = 7.7), and drug abuse (COR = 4.2). Interpersonal risk factors at the univariate level included relationship discord (COR = 4.0), physical partner abuse (COR = 2.5), nonphysical partner abuse (COR = 2.8), childhood maltreatment (COR = 3.2), and low levels of social support (COR = 2.6). A multivariate logistic regression model identified four variables that were strongly and independently associated with an increased risk for suicide attempts: psychological distress, hopelessness, drug abuse, and relationship discord. The model predicted suicide attempt status correctly 77% of the time. The results reveal that African American women who report high levels of psychological distress, hopelessness, drug use, and relationship discord should be assessed carefully for suicidal ideation and referred for appropriate mental health care.

Published
2000
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25. Impact of antibody specificity and calibration material on the measure of agreement between methods for cardiac troponin I.

Author

Newman DJ, Olabiran Y, Bedzyk WD, Chance S, Gorman EG, and Price CP

Subjects
Antibodies, Monoclonal, Antibody Specificity, Blotting, Western, Calibration, Humans, Reagent Kits, Diagnostic, Reference Standards, Regression Analysis, Reproducibility of Results, Troponin I immunology, Myocardium metabolism, Troponin I blood
Abstract

Background: Available assays for cardiac troponin I (cTnI) yield numerically different results. The aim of this study was to compare patient values obtained from four cTnI immunoassays., Methods: We studied the Stratus(R) II assay, the Opus(R) II assay, the Access(R) assay, and a research-only cTnI heterogeneous immunoassay that uses the Dade Behring aca(R) plus immunoassay system equipped with two new noncommercial monoclonal antibodies. Because the aca plus cTnI assay is for research only, we first evaluated and analytically validated it for serum and citrated plasma. Initially, each method was calibrated using the method-specific calibrator supplied by each manufacturer; however, the aca plus cTnI assay was calibrated using patient serum pools containing cTnI and selected on the basis of increased creatine kinase MB isoenzyme and with values assigned by use of the Stratus cTnI assay. For method comparisons, individual patient sample cTnI values were determined and compared with the Stratus II assay., Results: Passing and Bablock regression analysis yielded slopes of 1.44 (r = 0.96; n = 72) for the Opus II vs Stratus II assays; 0.07 (r = 0.91; n = 72) for the Access vs Stratus II assays; and 0.90 (r = 0.91, n = 72) for the aca plus vs Stratus II assays. The recalibration of each method with a Stratus II-assigned serum pool improved, but did not entirely eliminate, the slope differences between the different assays (range, 1.00-1.16). The observed scatter in the correlation curves remained., Conclusion: There is a need to further explore the specificities of these assays with respect to the different circulating forms of cTnI.

Published
1999

26. Factors that mediate and moderate the link between partner abuse and suicidal behavior in African American women.

Author

Kaslow NJ, Thompson MP, Meadows LA, Jacobs D, Chance S, Gibb B, Bornstein H, Hollins L, Rashid A, and Phillips K

Subjects
Adolescent, Adult, Black or African American statistics & numerical data, Comorbidity, Female, Humans, Middle Aged, Risk Factors, Social Support, Spouse Abuse statistics & numerical data, Substance-Related Disorders epidemiology, Substance-Related Disorders psychology, Suicide, Attempted statistics & numerical data, Black or African American psychology, Spouse Abuse psychology, Suicide, Attempted psychology
Abstract

Findings from a study comparing partner abuse in African American women suicide attempters (n = 148) and nonattempters (n = 137) revealed higher rates of physical and nonphysical partner abuse among attempters than their demographically similar nonsuicidal counterparts. The partner abuse--suicidal behavior link was mediated by psychological distress, hopelessness, and drug use and moderated by social support. Results also revealed that nonphysical partner abuse accounted for unique variance in the prediction of suicide attempt status beyond that attributable to childhood maltreatment. Implications of the findings for assessing both suicidal and abused women are discussed, and recommendations for preventive interventions for women at risk for suicidal behavior are provided.

Published
1998
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27. Computerized drug-use evaluation.

Author

O'Connell HM, Chance S, and Bowman L

Subjects
Angioedema complications, Humans, Hyperkalemia chemically induced, Kidney Function Tests, Outpatient Clinics, Hospital, Pharmacy and Therapeutics Committee, Angiotensin-Converting Enzyme Inhibitors adverse effects, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Drug Utilization Review, Medical Records Systems, Computerized
Abstract

A drug-use evaluation (DUE) of angiotensin-converting-enzyme (ACE) inhibitors by both manual and computerized methods was conducted. Criteria for the use of ACE inhibitors were developed and approved. Fifty patients were randomly selected from 225 clinic outpatients who had begun taking an ACE inhibitor during a six-month period. The clinic medical records of each of the patients were reviewed by a pharmacist to determine compliance with the DUE criteria. At the same time, a computer program queried the computerized medical records of the same patients to evaluate adherence to the criteria. The manual method showed that ACE inhibitor therapy met threshold for two of the six criteria before exceptions were considered and for three criteria after exceptions were considered. Results for only two criteria met threshold when evaluated by the computer; the computer did not consider exceptions. There was good or excellent percent agreement between the manual and computerized methods for four of the six criteria. Kappa values showed that the agreement for five criteria was significant. A computerized method of evaluating drug use performed similarly to manual evaluation, but agreement was best for simply stated criteria.

Published
1994

30. Interleukin 3 and cell cycle progression.

Author

Kelvin DJ, Chance S, Shreeve M, Axelrad AA, Connolly JA, and McLeod D

Subjects
Animals, Bone Marrow Cells, Cell Survival, DNA Replication, Interleukin-3, Interphase, Mast Cells cytology, Mice, Phenotype, Thymidine metabolism, Time Factors, Cell Cycle, Lymphokines physiology
Abstract

Interleukin 3 (IL-3) is a regulatory glycoprotein required for the proliferation and differentiation of cells from many if not all hemopoietic lineages. With the emergence of the competence-progression model of cell proliferation, which predicts that growth factors function at specific stages of the cell cycle, we examined the possibility that IL-3 functions at a specific stage of the cell cycle. C-63 cells were developed as a cell line from normal murine bone marrow. They have a mast cell phenotype and require pokeweed-stimulated spleen cell-conditioned medium (CM), a rich source of IL-3, for their continued growth. Exponentially growing cells were transferred from growth medium, which contains CM, to medium lacking CM or IL-3. After 24 hours, cell viability had decreased 40-50%. The remaining viable cells did not incorporate 3H-thymidine, and displayed a single peak at G1 in a DNA histogram. Restimulation of these cells with CM or IL-3 resulted in a dramatic rise in 3H-thymidine uptake 20-24 hours after restimulation. DNA histograms of restimulated cultures indicated that the cells were progressing in a wave-like fashion throughout the remainder of the cell cycle. The length of time necessary for cells to be in contact with CM or IL-3 before they could progress into the remainder of the cell cycle was also examined. Cells incubated with CM or IL-3 for less than 16 hours could not progress into S phase, whereas cells incubated for 16 hours or longer could progress into S phase and through the remainder of the cell cycle. These data suggest that IL-3 exerts its function at a specific stage of the cell cycle.

Published
1986
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