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10. Human vesicular glutamate transporters functionally complement EAT-4 in C. elegans.

Author

Lee D, Jung S, Ryu J, Ahnn J, and Ha I

Subjects
Amino Acid Sequence, Animals, Animals, Genetically Modified, Caenorhabditis elegans cytology, Caenorhabditis elegans Proteins chemistry, Caenorhabditis elegans Proteins genetics, Humans, Molecular Sequence Data, Protein Isoforms genetics, Receptors, Glutamate chemistry, Receptors, Glutamate genetics, Recombinant Fusion Proteins chemistry, Recombinant Fusion Proteins genetics, Recombinant Fusion Proteins metabolism, Sequence Alignment, Vesicular Glutamate Transport Proteins chemistry, Vesicular Glutamate Transport Proteins genetics, Caenorhabditis elegans metabolism, Caenorhabditis elegans Proteins metabolism, Protein Isoforms metabolism, Receptors, Glutamate metabolism, Vesicular Glutamate Transport Proteins metabolism
Abstract

The vesicular glutamate transporter (VGLUT) transports glutamate into pre-synaptic vesicles. Three isoforms of VGLUT have been identified in humans, but their functional differences remain largely unknown. EAT-4 is the only homologue of human VGLUT in C. elegans. Here we report that mutants of eat-4 exhibit hyperforaging behavior and that each of the isoforms of human VGLUT functionally rescues the defects in eat-4 worms.

Published
2008

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