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2 results on '"Ryoichi Arima"'

1. Nephrotic Syndrome with Thrombocytopenia, Lymphadenopathy, Systemic Inflammation, and Splenomegaly

Author

Fuyuko Akagaki, Ryoichi Arima, Yoshito Yamaguchi, Aya Nakamori, and Toshihiro Sugiura

Subjects
Pathology, medicine.medical_specialty, Nephrotic Syndrome, Tubular atrophy, 030232 urology & nephrology, Lymphadenopathy, Inflammation, Case Report, Systemic inflammation, Kidney, idiopathic multicentric Castleman Disease, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, renal dysfunction, Biopsy, Internal Medicine, Medicine, Humans, Renal Insufficiency, medicine.diagnostic_test, business.industry, urogenital system, General Medicine, TAFRO syndrome, small vessel lesions, Middle Aged, medicine.disease, Thrombocytopenia, Pathophysiology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Splenomegaly, Female, medicine.symptom, business, Nephrotic syndrome
Abstract

Nephrotic syndrome can be caused by various diseases, from primary kidney diseases to systemic diseases. A kidney biopsy is useful for confirming the causes of nephrotic syndrome and in its management. We herein describe a case of nephrotic syndrome with thrombocytopenia, lymphadenopathy, systemic inflammation, splenomegaly, kidney enlargement, and progressive renal insufficiency. A kidney biopsy showed endothelial swelling with mild interstitial fibrosis and tubular atrophy. This case met the diagnostic criteria for TAFRO syndrome. Little is known about TAFRO syndrome, especially in relation to the associated kidney pathophysiology. The accumulation of a greater number of cases in which the kidney biopsy findings are investigated is needed to clarify the pathogenesis of kidney involvement in this condition.

Published
2017

2. In-stent restenosis assessed with frequency domain optical coherence tomography shows smooth coronary arterial healing process in second-generation drug-eluting stents.

Author

Takashi Kajiya, Hiroshi Yamaguchi, Junichiro Takaoka, Kengo Fukunaga, Ryoichi Arima, Akihiro Miyamura, Toshiko Ninomiya, Nobuhiko Atsuchi, Yoshihiko Atsuchi, Mitsuyasu Terashima, Hideaki Kaneda, Mitsuru Ohishi, Kajiya, Takashi, Yamaguchi, Hiroshi, Takaoka, Junichiro, Fukunaga, Kengo, Arima, Ryoichi, Miyamura, Akihiro, Ninomiya, Toshiko, and Atsuchi, Nobuhiko

Subjects
OPTICAL coherence tomography, CORONARY angiography, MORPHOLOGY, PATHOLOGICAL physiology
Abstract

Introduction: The pathophysiology and mechanism of in-stent restenosis (ISR) after implantation of second-generation drug-eluting stents (DESs) are not fully clear. We compared the morphological characteristics of ISR between first- and second-generation DESs using frequency domain optical coherence tomography (OCT).Methods: Patients who underwent follow-up coronary angiography (CAG) after first-generation (CYPHER™ and TAXUS™) and second-generation (Nobori®, PROMUS Element™, Resolute Integrity and XIENCE) DES implantations were examined. ISR was defined as lesions of over 50% diameter stenosis at follow-up CAG. Frequency domain OCT was performed at the time of revascularisation of ISR. Tissue morphology was assessed at minimum lumen area. OCT images of DESs at both early (≤ 1 year) and late (> 1 year) phase follow-up were compared.Results: On qualitative OCT assessment, the ratios of homogeneous, layered, heterogeneous without-attenuation and heterogeneous with-attenuation morphologies were 57.1%, 17.1%, 20.0% and 5.7%, respectively, for second-generation DES ISR (n = 35), and 16.7%, 25.0%, 25.0% and 33.3%, respectively, for first-generation DES ISR (n = 36). At late phase follow-up, homogeneous morphology was significantly more common for second-generation DES ISR compared to first-generation DES ISR (first-generation: 8.0% vs. second-generation: 50.0%; p < 0.01) while heterogeneous with-attenuation morphology was significantly more common for first-generation DES ISR (first-generation: 44.0% vs. second-generation: 5.6%; p < 0.01).Conclusion: Homogeneous tissue morphology was more frequently found for second-generation than first-generation DES ISR, especially in the late phase. This suggested that neointimal hyperplasia was the main mechanism in second-generation DES ISR, and that the neointima was stabilised, much like in bare metal stent implantation. [ABSTRACT FROM AUTHOR]

Published
2019
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