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2. Immunomodulators for immunocompromised patients hospitalized for COVID-19: a meta-analysis of randomized controlled trials
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Hermine, Olivier, Mariette, Xavier, Ravaud, Philippe, Bureau, Serge, Dougados, Maxime, Resche-Rigon, Matthieu, Tharaux, Pierre-Louis, Tibi, Annick, Azoulay, Elie, Cadranel, Jacques, Emmerich, Joseph, Fartoukh, Muriel, Guidet, Bertrand, Humbert, Marc, Lacombe, Karine, Mahevas, Matthieu, Pene, Frédéric, Porcher, Raphaël, Pourchet-Martinez, Valerie, Schlemmer, Frédéric, Yazdanpanah, Yazdan, Baron, Gabriel, Perrodeau, Elodie, Vanhoye, Damien, Kedzia, Cécile, Demerville, Lauren, Gysembergh-Houal, Anne, Bourgoin, Alexandre, Raked, Nabil, Mameri, Lakhdar, Montlahuc, Claire, Biard, Lucie, Alary, St.phanie, Hamiria, Samir, Bariz, Thinhinane, Semri, Hala, Hai, Dhiaa Meriem, Benafla, Moustafa, Belloul, Mohamed, Vauboin, Pernelle, Flamand, Saskia, Pacheco, Claire, Walter-Petrich, Anouk, Stan, Emilia, Benarab, Souad, Nyanou, Corine, Charreteur, Robin, Dupre, Céline, Cardet, Kévin, Lehmann, Blandine, Baghli, Kamyl, Madelaine, Claire, D'Ortenzio, Eric, Puéchal, Oriane, Semaille, Caroline, Savale, 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F., Yazdanpanah, Y., Mentre, F., Peiffer-Smadja, N., Lescure, F.X., Poissy, J., Bouadma, L., Timsit, J.F., Lina, B., Morfin-Sherpa, F., Bouscambert, M., Gaymard, A., Peytavin, G., Abel, L., Guedj, J., Andrejak, C., Burdet, C., Laouenan, C., Belhadi, D., Dupont, A., Alfaiate, T., Basli, B., Chair, A., Laribi, S., Level, J., Schneider, M., Tellier, M.C., Dechanet, A., Costagliola, D., Terrier, B., Ohana, M., Couffin-Cadiergues, S., Esperou, H., Delmas, C., Saillard, J., Fougerou, C., Moinot, L., Wittkop, L., Cagnot, C., Le Mestre, S., Lebrasseur-Longuet, D., Petrov-Sanchez, V., Diallo, A., Mercier, N., Icard, V., Leveau, B., Tubiana, S., Hamze, B., Gelley, A., Noret, M., D’Ortenzio, E., Puechal, O., Semaille, C., Welte, T., Paiva, J.A., Halanova, M., Kieny, M.P., Balssa, E., Birkle, C., Gibowski, S., Landry, E., Le Goff, A., Moachon, L., Moins, C., Wadouachi, L., Paul, C., Levier, A., Bougon, D., Djossou, F., Epelboin, L., Dellamonica, J., Marquette, C.H., Robert, C., Gibot, S., Senneville, E., Jean-Michel, V., Zerbib, Y., Chirouze, C., Boyer, A., Cazanave, C., Gruson, D., Malvy, D., Andreu, P., Quenot, J.P., Terzi, N., Faure, K., Chabartier, C., Le Moing, V., Klouche, K., Ferry, T., F, Valour, Gaborit, B., Canet, E., Le Turnier, P., Boutoille, D., Bani-Sadr, F., Benezit, F., Revest, M., Cameli, C., Caro, A., Um Tegue, MJ Ngo, Le Tulzo, Y., Laviolle, B., Laine, F., Thiery, G., Meziani, F., Hansmann, Y., Oulehri, W., Tacquard, C., Vardon-Bounes, F., Riu-Poulenc, B., Murris-Espin, M., Bernard, L., Garot, D., Hinschberger, O., Martinot, M., Bruel, C., Pilmis, B., Bouchaud, O., Loubet, P., Roger, C., Monnet, X., Figueiredo, S., Godard, V., Mira, J.P., Lachatre, M., Kerneis, S., Aboab, J., Sayre, N., Crockett, F., Lebeaux, D., Buffet, A., Diehl, J.L., Fayol, A., Hulot, J.S., Livrozet, M., Dessap, A Mekontso, Ficko, C., Stefan, F., Le Pavec, J., Mayaux, J., Ait-Oufella, H., Molina, J.M., Pialoux, G., Fartoukh, M., Textoris, J., Brossard, M., Essat, A., Netzer, E., Riault, Y., Ghislain, M., Beniguel, L., Genin, M., Gouichiche, L., Betard, C., Belkhir, L., Altdorfer, A., Centro, V Fraipont, Braz, S., Ribeiro, JM Ferreira, Alburqueque, R Roncon, Berna, M., Alexandre, M., Lamprecht, B., Egle, A., Greil, R., Joannidis, M., Patterson, Thomas F., Ponce, Philip O., Taylor, Barbara S., Patterson, Jan E., Bowling, Jason E., Javeri, Heta, Kalil, Andre C., Larson, LuAnn, Hewlett, Angela, Mehta, Aneesh K., Rouphael, Nadine G., Saklawi, Youssef, Scanlon, Nicholas, Traenkner, Jessica J., Trible, Ronald P., Jr., Walter, Emmanuel B., Ivey, Noel, Holland, Thomas L., Ruiz-Palacios, Guillermo M., Ponce de León, Alfredo, Rajme, Sandra, Hsieh, Lanny, Amin, Alpesh N., Watanabe, Miki, Lee, Helen S., Kline, Susan, Billings, Joanne, Noren, Brooke, Kim, Hyun, Bold, Tyler D., Tapson, Victor, Grein, Jonathan, Sutterwala, Fayyaz, Iovine, Nicole, Beattie, Lars K., Wakeman, Rebecca Murray, Shaw, Matthew, Jain, Mamta K., Mocherla, Satish, Meisner, Jessica, Luque, Amneris, Sweeney, Daniel A., Benson, Constance A., Ali, Farhana, Atmar, Robert L., El Sahly, Hana M., Whitaker, Jennifer, Falsey, Ann R., Branche, Angela R., Rozario, Cheryl, Pineda, Justino Regalado, Martinez-Orozco, José Arturo, Lye, David Chien, Ong, Sean WX., Chia, Po Ying, Young, Barnaby E., Sandkovsky, Uriel, Berhe, Mezgebe, Haley, Clinton, Dishner, Emma, Cantos, Valeria D., Kelley, Colleen F., Rebolledo Esteinou, Paulina A., Kandiah, Sheetal, Doernberg, Sarah B., Crouch, Pierre-Cedric B., Jang, Hannah, Luetkemeyer, Anne F., Dwyer, Jay, Cohen, Stuart H., Thompson, George R., 3rd, Nguyen, Hien H., Finberg, Robert W., Wang, Jennifer P., Perez-Velazquez, Juan, Wessolossky, Mireya, Jackson, Patrick E.H., Bell, Taison D., West, Miranda J., Taiwo, Babafemi, Krueger, Karen, Perez, Johnny, Pearson, Triniece, Paules, Catharine I., Julian, Kathleen G., Ahmad, Danish, Hajduczok, Alexander G., Arguinchona, Henry, Arguinchona, Christa, Erdmann, Nathaniel, Goepfert, Paul, Ahuja, Neera, Frank, Maria G., Wyles, David, Young, Heather, Oh, Myoung-don, Park, Wan Beom, Kang, Chang Kyung, Marconi, Vincent, Moanna, Abeer, Cribbs, Sushma, Harrison, Telisha, Kim, Eu Suk, Jung, Jongtak, Song, Kyoung-Ho, Kim, Hong Bin, Tan, Seow Yen, Shafi, Humaira, Chien, Jaime, Fong, Raymond KC., Murray, Daniel D., Lundgren, Jens, Nielsen, Henrik, Jensen, Tomas, Zingman, Barry S., Grossberg, Robert, Riska, Paul F., Yang, Otto O., Ahn, Jenny, Arias, Rubi, Rapaka, Rekha R., Hauser, Naomi, Campbell, James D., Short, William R., Tebas, Pablo, Baron, Jillian T., McLellan, Susan L.F., Blanton, Lucas S., Seashore, Justin B., Creech, C. Buddy, Rice, Todd W., Walker, Shannon, Thomsen, Isaac P., Lopez de Castilla, Diego, Van Winkle, Jason W., Riedo, Francis X., Pada, Surinder Kaur, Wang, Alvin DY., Lin, Li, Harkins, Michelle, Mertz, Gregory, Sosa, Nestor, Ann Chai, Louis Yi, Tambyah, Paul Anantharajah, Tham, Sai Meng, Archuleta, Sophia, Yan, Gabriel, Lindholm, David A., Markelz, Ana Elizabeth, Mende, Katrin, Mularski, Richard, Hohmann, Elizabeth, Torres-Soto, Mariam, Jilg, Nikolaus, Maves, Ryan C., Utz, Gregory C., George, Sarah L., Hoft, Daniel F., Brien, James D., Paredes, Roger, Mateu, Lourdes, Loste, Cora, Kumar, Princy, Thornton, Sarah, Mohanraj, Sharmila, Hynes, Noreen A., Sauer, Lauren M., Colombo, Christopher J., Schofield, Christina, Colombo, Rhonda E., Chambers, Susan E., Novak, Richard M., Wendrow, Andrea, Gupta, Samir K., Lee, Tida, Lalani, Tahaniyat, Holodniy, Mark, Chary, Aarthi, Huprikar, Nikhil, Ganesan, Anuradha, Ohmagari, Norio, Mikami, Ayako, Price, D. Ashley, Duncan, Christopher J.A., Dierberg, Kerry, Neumann, Henry J., Taylor, Stephanie N., Lacour, Alisha, Masri, Najy, Swiatlo, Edwin, Widmer, Kyle, Neaton, James D., Bessesen, Mary, Stephens, David S., Burgess, Timothy H., Uyeki, Timothy M., Walker, Robert, Marks, G. Lynn, Osinusi, Anu, Cao, Huyen, Cardoso, Anabela, de Bono, Stephanie, Schlichting, Douglas E., Chung, Kevin K., Ferreira, Jennifer L., Green, Michelle, Makowski, Mat, Wierzbicki, Michael R., Conrad, Tom M., El-Khorazaty, Jill Ann, Hill, Heather, Bonnett, Tyler, Gettinger, Nikki, Engel, Theresa, Lewis, Teri, Wang, Jing, Beigel, John H., Tomashek, Kay M., Ghazaryan, Varduhi, Beresnev, Tatiana, Nayak, Seema, Dodd, Lori E., Dempsey, Walla, Nomicos, Effie, Lee, Marina, Pikaart-Tautges, Rhonda, Elsafy, Mohamed, Jurao, Robert, Koo, Hyung, Proschan, Michael, Yokum, Tammy, Arega, Janice, Florese, Ruth, Voell, Jocelyn D., Davey, Richard, Serrano, Ruth C., Wiley, Zanthia, Phadke, Varun K., Goepfert, Paul A., Gomez, Carlos A., Sofarelli, Theresa A., Certain, Laura, Imlay, Hannah N., Wolfe, Cameron R., Ko, Emily R., Engemann, John J., Felix, Nora Bautista, Wan, Claire R., Elmor, Sammy T., Bristow, Laurel R., Harkins, Michelle S., Iovine, Nicole M., Elie-Turenne, Marie-Carmelle, Tapson, Victor F., Choe, Pyoeng Gyun, Mularski, Richard A., Rhie, Kevin S., Hussein, Rezhan H., Ince, Dilek, Winokur, Patricia L., Takasaki, Jin, Saito, Sho, McConnell, Kimberly, Wyles, David L., Sarcone, Ellen, Grimes, Kevin A., Perez, Katherine, Janak, Charles, Whitaker, Jennifer A., Rebolledo, Paulina A., Gharbin, John, Lambert, Allison A., Zea, Diego F., Bainbridge, Emma, Hostler, David C., Hostler, Jordanna M., Shahan, Brian T., Ling, Evelyn, Go, Minjoung, Hubbard, Fleesie A., Chakrabarty, Melony, Laguio-Vila, Maryrose, Walsh, Edward E., Guirgis, Faheem, Marconi, Vincent C., Madar, Christian, Borgetti, Scott A., Levine, Corri, Nock, Joy, Candiotti, Keith, Rozman, Julia, Dangond, Fernando, Hyvert, Yann, Seitzinger, Andrea, Cross, Kaitlyn, Pettibone, Stephanie, Nayak, Seema U., Deye, Gregory A., Siempos, Ilias I., Belhadi, Drifa, Veiga, Viviane Cordeiro, Cavalcanti, Alexandre Biasi, Branch-Elliman, Westyn, Papoutsi, Eleni, Gkirgkiris, Konstantinos, Xixi, Nikoleta A., and Kotanidou, Anastasia
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- 2024
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3. Immunomodulators for immunocompromised patients hospitalized for COVID-19: a meta-analysis of randomized controlled trialsResearch in context
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Ilias I. Siempos, Andre C. Kalil, Drifa Belhadi, Viviane Cordeiro Veiga, Alexandre Biasi Cavalcanti, Westyn Branch-Elliman, Eleni Papoutsi, Konstantinos Gkirgkiris, Nikoleta A. Xixi, Anastasia Kotanidou, Olivier Hermine, Raphaël Porcher, Xavier Mariette, Philippe Ravaud, Serge Bureau, Maxime Dougados, Matthieu Resche-Rigon, Pierre-Louis Tharaux, Annick Tibi, Elie Azoulay, Jacques Cadranel, Joseph Emmerich, Muriel Fartoukh, Bertrand Guidet, Marc Humbert, Karine Lacombe, Matthieu Mahevas, Frédéric Pene, Valerie Pourchet-Martinez, Frédéric Schlemmer, Yazdan Yazdanpanah, Gabriel Baron, Elodie Perrodeau, Damien Vanhoye, Cécile Kedzia, Lauren Demerville, Anne Gysembergh-Houal, Alexandre Bourgoin, Nabil Raked, Lakhdar Mameri, Claire Montlahuc, Lucie Biard, St.phanie Alary, Samir Hamiria, Thinhinane Bariz, Hala Semri, Dhiaa Meriem Hai, Moustafa Benafla, Mohamed Belloul, Pernelle Vauboin, Saskia Flamand, Claire Pacheco, Anouk Walter-Petrich, Emilia Stan, Souad Benarab, Corine Nyanou, Robin Charreteur, Céline Dupre, Kévin Cardet, Blandine Lehmann, Kamyl Baghli, Claire Madelaine, Eric D'Ortenzio, Oriane Puéchal, Caroline Semaille, Laurent Savale, Anatole Harrois, Samy Figueiredo, Jacques Duranteau, Nadia Anguel, Arthur Pavot, Xavier Monnet, Christian Richard, Jean-Louis Teboul, Philippe Durand, Pierre Tissieres, Mitja Jevnikar, David Montani, Stephan Pavy, Gaétane Nocturne, Samuel Bitoun, Nicolas Noel, Olivier Lambotte, Lelia Escaut, Stephane Jauréguiberry, Elodie Baudry, Christiane Verny, Edouard Lefevre, Mohamad Zaidan, Domitille Molinari, Gaël Leprun, Alain Fourreau, Laurent Cylly, Lamiae Grimaldi, Myriam Virlouvet, Ramdane Meftali, Soléne Fabre, Marion Licois, Asmaa Mamoune, Yacine Boudali, Clotilde Le Tiec, Céline Verstuyft, Anne-Marie Roques, Sophie Georgin-Lavialle, Patricia Senet, Gilles Pialoux, Angele Soria, Antoine Parrot, Helene François, Nathalie Rozensztajn, Emmanuelle Blin, Pascaline Choinier, Juliette Camuset, Jean-Simon Rech, Antony Canellas, Camille Rolland-Debord, Nadege Lemarié, Nicolas Belaube, Marine Nadal, Martin Siguier, Camille Petit-Hoang, Julie Chas, Elodie Drouet, Matthieu Lemoine, Audrey Phibel, Lucie Aunay, Eliane Bertrand, Sylviane Ravato, Marie Vayssettes, Anne Adda, Celine Wilpotte, Pélagie Thibaut, Julie Fillon, Isabelle Debrix, Soraya Fellahi, Jean-Philippe Bastard, Guillaume Lefévre, Jacques-Eric Gottenberg, Yves Hansmann, Frédéric Blanc, Sophie Ohlmann-Caillard, Vincent Castelain, Emmanuel Chatelus, Eva Chatron, Olivier Collange, François Danion, Frédéric De Blay, Pierre Diemunsch, Sophie Diemunsch, Renaud Felten, Bernard Goichot, Valentin Greigert, Aurelien Guffroy, Bob Heger, Charlotte Kaeuffer, Loic Kassegne, Anne Sophie Korganow, Pierrick Le Borgne, Nicolas Lefebvre, Paul-Michel Mertes, Eric Noll, Mathieu Oberlin, Vincent Poindron, Julien Pottecher, Yvon Ruch, François Weill, Nicolas Meyer, Emmanuel Andres, Eric Demonsant, Hakim Tayebi, Gabriel Nisand, Stéphane Brin, Cédric Sublon, Guillaume Becker, Anne Hutt, Tristan Martin, Sophie Bayer, Catherine Metzger, Arsene Mekinian, Noémie Abisror, Amir Adedjouma, Diane Bollens, Marion Bonneton, Nathalie Bourcicaux, Anne Bourrier, Maria Chauchard Thibault Chiarabiani, Doroth.e Chopin, Jonathan Cohen, Ines Devred, Bruno Donadille, Olivier Fain, Geoffrey Hariri, Vincent Jachiet, Patrick Ingliz, Marc Garnier, Marc Gatfosse, Etienne Ghrenassia, Delphine Gobert, Jessica Krause le Garrec, Cecilia Landman, Jean Remy Lavillegrand, Benedicte Lefebvre, Thibault Mahevas, Sandie Mazerand, Jean Luc Meynard, Marjolaine Morgand, Zineb Ouaz.ne, Jerome Pacanowski, S.bastien Riviere, Philippe Seksik, Harry Sokol, Heithem Soliman, Nadia Valin, Thomas Urbina, Chloé McAvoy, Maria Pereira Miranda, Gladys Aratus, Laurence Berard, Tabassome Simon, Anne Daguenel Nguyen, Elise Girault, Cl.mentine Mayala-Kanda, Marie Antignac, Céline Leplay, Jean-Benoit Arlet, Jean-Luc Diehl, Florence Bellenfant, Anne Blanchard, Alexandre Buffet, Bernard Cholley, Antoine Fayol, Edouard Flamarion, Anne Godier, Thomas Gorget, Sophie-Rym Hamada, Caroline Hauw-Berlemont, Jean-Sébastien Hulot, David Lebeaux, Marine Livrozet, Adrien Michon, Arthur Neuschwander, Marie-Aude Pennet, Benjamin Planquette, Brigitte Ranque, Olivier Sanchez, Geoffroy Volle, Sandrine Briois, Mathias Cornic, Virginie Elisee, Jesuthasan Denis, Juliette Djadi-Prat, Pauline Jouany, Ramon Junquera, Mickael Henriques, Amina Kebir, Isabelle Lehir, Jeanne Meunier, Florence Patin, Val.rie Paquet, Anne Tréhan, Véronique Vigna, Brigitte Sabatier, Damien Bergerot, Charléne Jouve, Camille Knosp, Olivia Lenoir, Nassim Mahtal, Léa Resmini, Xavier Lescure, Jade Ghosn, Antoine Bachelard, Anne Rachline, Valentina Isernia, Bao-chau, Phung, Dorothée Vallois, Aurelie Sautereau, Catherine Neukrich, Antoine Dossier, Raphaël Borie, Bruno Crestani, Gregory Ducrocq, Philippe Gabriel Steg, Philippe Dieude, Thomas Papo, Estelle Marcault, Marhaba Chaudhry, Charléne Da Silveira, Annabelle Metois, Ismahan Mahenni, Meriam Meziani, Cyndie Nilusmas, Sylvie Le Gac, Awa Ndiaye, Fran.oise Louni, Malikhone Chansombat, Zelie Julia, Solaya Chalal, Lynda Chalal, Laura Kramer, Jeniffer Le Grand, Kafif Ouifiya, Valentine Piquard, Sarah Tubiana, Yann Nguyen, Vasco Honsel, Emmanuel Weiss, Anais Codorniu, Virginie Zarrouk, Victoire de Lastours, Matthieu Uzzan, Naura Gamany, Agathe Claveirole, Alexandre Navid, Tiffanie Fouque, Yonathan Cohen, Maya Lupo, Constance Gilles, Roza Rahli, Zeina Louis, David Boutboul, Lionel Galicier, Yaël Amara, Gabrielle Archer, Amira Benattia, Anne Bergeron, Louise Bondeelle, Nathalie de Castro, Melissa Clément, Michaël Darmon, Blandine Denis, Clairelyne Dupin, Elsa Feredj, Delphine Feyeux, Adrien Joseph, Etienne Lenglin, Pierre Le Guen, Geoffroy Liégeon, Gwenaël Lorillon, Asma Mabrouki, Eric Mariotte, Grégoire Martin de Frémont, Adrien Mirouse, Jean-Michel Molina, Régis Peffault de Latour, Eric Oksenhendler, Julien Saussereau, Abdellatif Tazi, Jean-Jacques Tudesq, Lara Zafrani, Isabelle Brindele, Emmanuelle Bugnet, Karine Celli Lebras, Julien Chabert, Lamia Djaghout, Catherine Fauvaux, Anne Lise Jegu, Ewa Kozakiewicz, Martine Meunier, Marie-Thérèse Tremorin, Claire Davoine, Isabelle Madelaine, Sophie Caillat-Zucman, Constance Delaugerre, Florence Morin, Damien Sène, Ruxandra Burlacu, Benjamin Chousterman, Bruno Mégarbanne, Pascal Richette, Jean-Pierre Riveline, Aline Frazier, Eric Vicaut, Laure Berton, Tassadit Hadjam, Miguel Alejandro Vazquez-Ibarra, Clément Jourdaine, Olivia Tran, Véronique Jouis, Aude Jacob, Julie Smati, Stéphane Renaud, Claire Pernin, Lydia Suarez, Luca Semerano, Sébastien Abad, Ruben B. nainous, Nicolas Bonnet, Celine Comparon, Yves Cohen, Hugues Cordel, Robin Dhote, Nathalie Dournon, Boris Duchemann, Nathan Ebstein, Thomas Gille, Benedicte Giroux-Leprieur, Jeanne Goupil de Bouille, Hilario Nunes, Johanna Oziel, Dominique Roulot, Lucile Sese, ClaireTantet, Yurdagul Uzunhan, Coralie Bloch-Queyrat, Vincent Levy, Fadhila Messani, Mohammed Rahaoui, Myléne Petit, Sabrina Brahmi, Vanessa Rathoin, Marthe Rigal, Nathalie Costedoat-Chalumeau, Liem Binh Luong, Zakaria Ait Hamou, Sarah Benghanem, Philippe Blanche, Nicolas Carlier, Benjamin Chaigne, Remy Gauzit, Hassan Joumaa, Mathieu Jozwiak, Marie Lachétre, Hélène Lafoeste, Odie Launay, Paul Legendre, Jonathan Marey, Caroline Morbieu, Lola-Jade Palmieri, Tali-Anne Szwebel, Hendy Abdoul, Alexandra Bruneau, Audrey Beclin-Clabaux, Charly Larrieu, Pierre Montanari, Eric Dufour, Ada Clarke, Catherine Le Bourlout, Nathalie Marin, Nathalie Menage, Samira Saleh-Mghir, Mamadou Salif Cisse, Kahina Cheref, Corinne Guerin, Jérémie Zerbit, Marc Michel, Sébastien Gallien, Etienne Crickx, Benjamin Le Vavasseur, Emmanuelle Kempf, Karim Jaffal, William Vindrios, Julie Oniszczuk, Constance Guillaud, Pascal Lim, Elena Fois, Giovanna Melica, Marie Matignon, Maud Jalabert, Jean-Daniel Lelièvre, David Schmitz, Marion Bourhis, Sylia Belazouz, Laetitia Languille, Caroline Boucle, Nelly Cita, Agnés Didier, Fahem Froura, Katia Ledudal, Thiziri Sadaoui, Alaki Thiemele, Delphine Le Febvre De Bailly, Muriel Carvhalo Verlinde, Julien Mayaux, Patrice Cacoub, David Saadoun, Mathieu Vautier, Héléne Bugaut, Olivier Benveniste, Yves Allenbach, Gaëlle Leroux, Aude Rigolet, Perrine Guillaume-Jugnot, Fanny Domont, Anne Claire Desbois, Chloé Comarmond, Nicolas Champtiaux, Segolene Toquet, Amine Ghembaza, Matheus Vieira, Georgina Maalouf, Goncalo Boleto, Yasmina Ferfar, Jean-Christophe Corvol, C.line Louapre, Sara Sambin, Louise-Laure Mariani, Carine Karachi, Florence Tubach, Candice Estellat, Linda Gimeno, Karine Martin, Aicha Bah, Vixra Keo, Sabrine Ouamri, Yasmine Messaoudi, Nessima Yelles, Pierre Faye, Sebastien Cavelot, Cecile Larcheveque, Laurence Annonay, Jaouad Benhida, Aida Zahrate-Ghoul, Soumeya Hammal, Ridha Belilita, Fanny Charbonnier, Claire Aguilar, Fanny Alby-Laurent, Carole Burger, Clara Campos-Vega, Nathalie Chavarot, Benjamin Fournier, Claire Rouzaud, Damien Vimpére, Caroline Elie, Prissile Bakouboula, Laure Choupeaux, Sophie Granville, Elodie Issorat, Christine Broissand, Marie-Alexandra Alyanakian, Guillaume Geri, Nawal Derridj, Naima Sguiouar, Hakim Meddah, Mourad Djadel, Héléne Chambrin-Lauvray, Jean-Charles Duclos-vallée, Faouzi Saliba, Sophie-Caroline Sacleux, Ilias Kounis, Sonia Tamazirt, Eric Rudant, Jean-Marie Michot, Annabelle Stoclin, Emeline Colomba, Fanny Pommeret, Christophe Willekens, Rosa Da Silva, Valérie Dejean, Yasmina Mekid, Ines Ben-Mabrouk, Florence Netzer, Caroline Pradon, Laurence Drouard, Valérie Camara-Clayette, Alexandre Morel, Gilles Garcia, Abolfazl Mohebbi, Férial Berbour, Mélanie Dehais, Anne-Lise Pouliquen, Alison Klasen, Loren Soyez-Herkert, Jonathan London, Younes Keroumi, Emmanuelle Guillot, Guillaume Grailles, Younes El amine, Fanny Defrancq, Hanane Fodil, Chaouki Bouras, Dominique Dautel, Nicolas Gambier, Thierno Dieye, Boris Bienvenu, Victor Lancon, Laurence Lecomte, Kristina Beziriganyan, Belkacem Asselate, Laure Allanic, Elena Kiouris, Marie-Héléne Legros, Christine Lemagner, Pascal Martel, Vincent Provitolo, Félix Ackermann, Mathilde Le Marchand, Aurélie Chan Hew Wai, Dimitri Fremont, Elisabeth Coupez, Mireille Adda, Frédéric Duée, Lise Bernard, Antoine Gros, Estelle Henry, Claire Courtin, Anne Pattyn, Pierre-Grégoire Guinot, Marc Bardou, Agnes Maurer, Julie Jambon, Amélie Cransac, Corinne Pernot, Bruno Mourvillier, Eric Marquis, Philippe Benoit, Damien Roux, Coralie Gernez, Cécile Yelnik, Julien Poissy, Mandy Nizard, Fanette Denies, Helene Gros, Jean-Jacques Mourad, Emmanuelle Sacco, Sophie Renet, F. Ader, Y. Yazdanpanah, F. Mentre, N. Peiffer-Smadja, F.X. Lescure, J. Poissy, L. Bouadma, J.F. Timsit, B. Lina, F. Morfin-Sherpa, M. Bouscambert, A. Gaymard, G. Peytavin, L. Abel, J. Guedj, C. Andrejak, C. Burdet, C. Laouenan, D. Belhadi, A. Dupont, T. Alfaiate, B. Basli, A. Chair, S. Laribi, J. Level, M. Schneider, M.C. Tellier, A. Dechanet, D. Costagliola, B. Terrier, M. Ohana, S. Couffin-Cadiergues, H. Esperou, C. Delmas, J. Saillard, C. Fougerou, L. Moinot, L. Wittkop, C. Cagnot, S. Le Mestre, D. Lebrasseur-Longuet, V. Petrov-Sanchez, A. Diallo, N. Mercier, V. Icard, B. Leveau, S. Tubiana, B. Hamze, A. Gelley, M. Noret, E. D’Ortenzio, O. Puechal, C. Semaille, T. Welte, J.A. Paiva, M. Halanova, M.P. Kieny, E. Balssa, C. Birkle, S. Gibowski, E. Landry, A. Le Goff, L. Moachon, C. Moins, L. Wadouachi, C. Paul, A. Levier, D. Bougon, F. Djossou, L. Epelboin, J. Dellamonica, C.H. Marquette, C. Robert, S. Gibot, E. Senneville, V. Jean-Michel, Y. Zerbib, C. Chirouze, A. Boyer, C. Cazanave, D. Gruson, D. Malvy, P. Andreu, J.P. Quenot, N. Terzi, K. Faure, C. Chabartier, V. Le Moing, K. Klouche, T. Ferry, F, Valour, B. Gaborit, E. Canet, P. Le Turnier, D. Boutoille, F. Bani-Sadr, F. Benezit, M. Revest, C. Cameli, A. Caro, MJ Ngo Um Tegue, Y. Le Tulzo, B. Laviolle, F. Laine, G. Thiery, F. Meziani, Y. Hansmann, W. Oulehri, C. Tacquard, F. Vardon-Bounes, B. Riu-Poulenc, M. Murris-Espin, L. Bernard, D. Garot, O. Hinschberger, M. Martinot, C. Bruel, B. Pilmis, O. Bouchaud, P. Loubet, C. Roger, X. Monnet, S. Figueiredo, V. Godard, J.P. Mira, M. Lachatre, S. Kerneis, J. Aboab, N. Sayre, F. Crockett, D. Lebeaux, A. Buffet, J.L. Diehl, A. Fayol, J.S. Hulot, M. Livrozet, A Mekontso- Dessap, C. Ficko, F. Stefan, J. Le Pavec, J. Mayaux, H. Ait-Oufella, J.M. Molina, G. Pialoux, M. Fartoukh, J. Textoris, M. Brossard, A. Essat, E. Netzer, Y. Riault, M. Ghislain, L. Beniguel, M. Genin, L. Gouichiche, C. Betard, L. Belkhir, A. Altdorfer, V Fraipont Centro, S. Braz, JM Ferreira Ribeiro, R Roncon Alburqueque, M. Berna, M. Alexandre, B. Lamprecht, A. Egle, R. Greil, M. Joannidis, Thomas F. Patterson, Philip O. Ponce, Barbara S. Taylor, Jan E. Patterson, Jason E. Bowling, Heta Javeri, LuAnn Larson, Angela Hewlett, Aneesh K. Mehta, Nadine G. Rouphael, Youssef Saklawi, Nicholas Scanlon, Jessica J. Traenkner, Ronald P. Trible, Jr., Emmanuel B. Walter, Noel Ivey, Thomas L. Holland, Guillermo M. Ruiz-Palacios, Alfredo Ponce de León, Sandra Rajme, Lanny Hsieh, Alpesh N. Amin, Miki Watanabe, Helen S. Lee, Susan Kline, Joanne Billings, Brooke Noren, Hyun Kim, Tyler D. Bold, Victor Tapson, Jonathan Grein, Fayyaz Sutterwala, Nicole Iovine, Lars K. Beattie, Rebecca Murray Wakeman, Matthew Shaw, Mamta K. Jain, Satish Mocherla, Jessica Meisner, Amneris Luque, Daniel A. Sweeney, Constance A. Benson, Farhana Ali, Robert L. Atmar, Hana M. El Sahly, Jennifer Whitaker, Ann R. Falsey, Angela R. Branche, Cheryl Rozario, Justino Regalado Pineda, José Arturo Martinez-Orozco, David Chien Lye, Sean WX. Ong, Po Ying Chia, Barnaby E. Young, Uriel Sandkovsky, Mezgebe Berhe, Clinton Haley, Emma Dishner, Valeria D. Cantos, Colleen F. Kelley, Paulina A. Rebolledo Esteinou, Sheetal Kandiah, Sarah B. Doernberg, Pierre-Cedric B. Crouch, Hannah Jang, Anne F. Luetkemeyer, Jay Dwyer, Stuart H. Cohen, George R. Thompson, 3rd, Hien H. Nguyen, Robert W. Finberg, Jennifer P. Wang, Juan Perez-Velazquez, Mireya Wessolossky, Patrick E.H. Jackson, Taison D. Bell, Miranda J. West, Babafemi Taiwo, Karen Krueger, Johnny Perez, Triniece Pearson, Catharine I. Paules, Kathleen G. Julian, Danish Ahmad, Alexander G. Hajduczok, Henry Arguinchona, Christa Arguinchona, Nathaniel Erdmann, Paul Goepfert, Neera Ahuja, Maria G. Frank, David Wyles, Heather Young, Myoung-don Oh, Wan Beom Park, Chang Kyung Kang, Vincent Marconi, Abeer Moanna, Sushma Cribbs, Telisha Harrison, Eu Suk Kim, Jongtak Jung, Kyoung-Ho Song, Hong Bin Kim, Seow Yen Tan, Humaira Shafi, MF Jaime Chien, Raymond KC. Fong, Daniel D. Murray, Jens Lundgren, Henrik Nielsen, Tomas Jensen, Barry S. Zingman, Robert Grossberg, Paul F. Riska, Otto O. Yang, Jenny Ahn, Rubi Arias, Rekha R. Rapaka, Naomi Hauser, James D. Campbell, William R. Short, Pablo Tebas, Jillian T. Baron, Susan L.F. McLellan, Lucas S. Blanton, Justin B. Seashore, C. Buddy Creech, Todd W. Rice, Shannon Walker, Isaac P. Thomsen, Diego Lopez de Castilla, Jason W. Van Winkle, Francis X. Riedo, Surinder Kaur Pada, Alvin DY. Wang, Li Lin, Michelle Harkins, Gregory Mertz, Nestor Sosa, Louis Yi Ann Chai, Paul Anantharajah Tambyah, Sai Meng Tham, Sophia Archuleta, Gabriel Yan, David A. Lindholm, Ana Elizabeth Markelz, Katrin Mende, Richard Mularski, Elizabeth Hohmann, Mariam Torres-Soto, Nikolaus Jilg, Ryan C. Maves, Gregory C. Utz, Sarah L. George, Daniel F. Hoft, James D. Brien, Roger Paredes, Lourdes Mateu, Cora Loste, Princy Kumar, Sarah Thornton, Sharmila Mohanraj, Noreen A. Hynes, Lauren M. Sauer, Christopher J. Colombo, Christina Schofield, Rhonda E. Colombo, Susan E. Chambers, Richard M. Novak, Andrea Wendrow, Samir K. Gupta, Tida Lee, Tahaniyat Lalani, Mark Holodniy, Aarthi Chary, Nikhil Huprikar, Anuradha Ganesan, Norio Ohmagari, Ayako Mikami, D. Ashley Price, Christopher J.A. Duncan, Kerry Dierberg, Henry J. Neumann, Stephanie N. Taylor, Alisha Lacour, Najy Masri, Edwin Swiatlo, Kyle Widmer, James D. Neaton, Mary Bessesen, David S. Stephens, Timothy H. Burgess, Timothy M. Uyeki, Robert Walker, G. Lynn Marks, Anu Osinusi, Huyen Cao, Anabela Cardoso, Stephanie de Bono, Douglas E. Schlichting, Kevin K. Chung, Jennifer L. Ferreira, Michelle Green, Mat Makowski, Michael R. Wierzbicki, Tom M. Conrad, Jill Ann El-Khorazaty, Heather Hill, Tyler Bonnett, Nikki Gettinger, Theresa Engel, Teri Lewis, Jing Wang, John H. Beigel, Kay M. Tomashek, Varduhi Ghazaryan, Tatiana Beresnev, Seema Nayak, Lori E. Dodd, Walla Dempsey, Effie Nomicos, Marina Lee, Rhonda Pikaart-Tautges, Mohamed Elsafy, Robert Jurao, Hyung Koo, Michael Proschan, Tammy Yokum, Janice Arega, Ruth Florese, Jocelyn D. Voell, Richard Davey, Ruth C. Serrano, Zanthia Wiley, Varun K. Phadke, Paul A. Goepfert, Carlos A. Gomez, Theresa A. Sofarelli, Laura Certain, Hannah N. Imlay, Cameron R. Wolfe, Emily R. Ko, John J. Engemann, Nora Bautista Felix, Claire R. Wan, Sammy T. Elmor, Laurel R. Bristow, Michelle S. Harkins, Nicole M. Iovine, Marie-Carmelle Elie-Turenne, Victor F. Tapson, Pyoeng Gyun Choe, Richard A. Mularski, Kevin S. Rhie, Rezhan H. Hussein, Dilek Ince, Patricia L. Winokur, Jin Takasaki, Sho Saito, Kimberly McConnell, PharmD, David L. Wyles, Ellen Sarcone, Kevin A. Grimes, Katherine Perez, Charles Janak, Jennifer A. Whitaker, Paulina A. Rebolledo, John Gharbin, Allison A. Lambert, Diego F. Zea, Emma Bainbridge, David C. Hostler, Jordanna M. Hostler, Brian T. Shahan, Evelyn Ling, Minjoung Go, Fleesie A. Hubbard, Melony Chakrabarty, Maryrose Laguio-Vila, Edward E. Walsh, Faheem Guirgis, Vincent C. Marconi, Christian Madar, Scott A. Borgetti, Corri Levine, Joy Nock, Keith Candiotti, Julia Rozman, Fernando Dangond, Yann Hyvert, Andrea Seitzinger, Kaitlyn Cross, Stephanie Pettibone, Seema U. Nayak, and Gregory A. Deye
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Acute respiratory distress syndrome ,Acute hypoxemic respiratory failure ,Pneumonia ,Critically ill ,Cancer ,Medicine (General) ,R5-920 - Abstract
Summary: Background: Although immunomodulators have established benefit against the new coronavirus disease (COVID-19) in general, it is uncertain whether such agents improve outcomes without increasing the risk of secondary infections in the specific subgroup of previously immunocompromised patients. We assessed the effect of immunomodulators on outcomes of immunocompromised patients hospitalized for COVID-19. Methods: The protocol was prospectively registered with PROSPERO (CRD42022335397). MEDLINE, Cochrane Central Register of Controlled Trials and references of relevant articles were searched up to 01-06-2022. Authors of potentially eligible randomized controlled trials were contacted to provide data on immunocompromised patients randomized to immunomodulators vs control (i.e., placebo or standard-of-care). Findings: Eleven randomized controlled trials involving 397 immunocompromised patients hospitalized for COVID-19 were included. Ten trials had low risk of bias. There was no difference between immunocompromised patients randomized to immunomodulators vs control regarding mortality [30/182 (16.5%) vs 41/215 (19.1%); RR 0.93, 95% CI 0.61–1.41; p = 0.74], secondary infections (RR 1.00, 95% CI 0.64–1.58; p = 0.99) and change in World Health Organization ordinal scale from baseline to day 15 (weighed mean difference 0.27, 95% CI -0.09–0.63; p = 0.15). In subgroup analyses including only patients with hematologic malignancy, only trials with low risk of bias, only trials administering IL-6 inhibitors, or only trials administering immunosuppressants, there was no difference between comparators regarding mortality. Interpretation: Immunomodulators, compared to control, were not associated with harmful or beneficial outcomes, including mortality, secondary infections, and change in ordinal scale, when administered to immunocompromised patients hospitalized for COVID-19. Funding: Hellenic Foundation for Research and Innovation.
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- 2024
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4. Absence of association between CT-assessed skeletal muscle mass and long-term oncological outcomes after curative therapy for colorectal liver metastasis
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Meyer, Yannick M., Galjart, Boris, Waalboer, Ruben B., Olthof, Pim B., van Vugt, Jeroen L.A., Grünhagen, Dirk J., and Verhoef, Cornelis
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- 2022
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5. An efficient transformation method for genome editing of elite bread wheat cultivars
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Akshaya K. Biswal, L. Ruben B. Hernandez, Ana I. R. Castillo, Juan M. Debernardi, and Kanwarpal S. Dhugga
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wheat ,transformation ,GRF4-GIF1 ,particle bombardment ,gene editing ,CRISPR-Cas ,Plant culture ,SB1-1110 - Abstract
An efficient genetic transformation protocol is necessary to edit genes for trait improvement directly in elite bread wheat cultivars. We used a protein fusion between a wheat growth-regulating factor 4 (GRF4) and its interacting factor (GIF1) to develop a reproducible genetic transformation and regeneration protocol, which we then used to successfully transform elite bread wheat cultivars Baj, Kachu, Morocco, Reedling, RL6077, and Sujata in addition to the experimental cultivar Fielder. Immature embryos were transformed with the vector using particle bombardment method. Transformation frequency increased nearly 60-fold with the GRF4-GIF1-containing vectors as compared to the control vector and ranged from ~5% in the cultivar Kachu to 13% in the cultivar RL6077. We then edited two genes that confer resistance against leaf rust and powdery mildew directly in the aforementioned elite cultivars. A wheat promoter, TaU3 or TaU6, to drive the expression of guide RNA was effective in gene editing whereas the OsU3 promoter failed to generate any edits. Editing efficiency was nearly perfect with the wheat promoters. Our protocol has made it possible to edit genes directly in elite wheat cultivars and would be useful for gene editing in other wheat varieties, which have been recalcitrant to transformation thus far.
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- 2023
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6. The Influence Gap: Unequal Policy Responsiveness to Men and Women.
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Mathisen, Ruben B.
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GOVERNMENT policy , *WOMEN in politics , *GENDER differences (Sociology) , *PUBLIC opinion - Abstract
Despite decades of research on women's representation, we still know surprisingly little about the extent to which public policy responds unequally to the preferences of women and men. This article exploits two comparable data sets, one for the United States and one for Norway, together containing measures of gender-disaggregated public opinion, as well as public policy outcomes, on 2,650 specific proposals asked about in survey polls between 1964 and 2014. The data reveal a substantial gap in policy responsiveness to men and women (in favor of men) in both countries. However, in Norway, the gender gap has virtually disappeared over time, a development that appears to be attributable to the increasing share of women in parliament. In the United States, the gap has remained remarkably stable over time. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Differential-Evolution-Assisted Optimization of Classical Compensation Topologies for 1 W Current-Fed IMD Wireless Charging Systems
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Ianca M. S. de Jesus, Thaís M. Tolfo, Ruben B. Godoy, Matheus de C. Pelzl, Beatriz de S. Acosta, and Rafael L. R. Soares
- Subjects
implantable medical devices (IMDs) ,wireless power transfer ,Differential-Evolution-based algorithm ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Implantable medical devices (IMDs) necessitate a consistent energy supply, commonly sourced from an embedded battery. However, given the finite lifespan of batteries, periodic replacement becomes imperative. This paper addresses the challenge by introducing a wireless power transfer system designed specifically for implantable medical devices (IMDs). It begins with a detailed analysis of the four conventional topologies. Following this, the paper provides a thorough explanation for choosing the PS topology, highlighting its advantages and suitability for the intended application. The primary parallel capacitance necessitates power from current sources; thus, a Class-E amplifier was implemented. Additionally, the selected circuit was engineered to deliver 1 W at the biocompatible resonance frequency of 13.56 MHz. The delineation of the resonance parameters hinges on multifaceted solutions, encompassing bifurcation-free operation and the attainment of peak efficiency. To ensure the feasibility of the proposed solution, a Differential-Evolution-based algorithm was employed. The results obtained from simulation-based evaluations indicated that the system achieved an efficiency exceeding 86%. This efficiency level was maintained even in the face of frequency fluctuations and variations in the coupling between the coils, thereby ensuring stable operational performance. This aligns seamlessly with the specified application prerequisites, guaranteeing a feasible and reliable operation.
- Published
- 2023
- Full Text
- View/download PDF
8. Sarcopenia and long-term survival outcomes after local therapy for colorectal liver metastasis: a meta-analysis
- Author
-
Waalboer, Ruben B., Meyer, Yannick M., Galjart, Boris, Olthof, Pim B., van Vugt, Jeroen L.A., Grünhagen, Dirk J., and Verhoef, Cornelis
- Published
- 2022
- Full Text
- View/download PDF
9. Predictors of outcome in the ISCHEMIA-CKD trial: Anatomy versus ischemia
- Author
-
Bainey, Kevin R., Fleg, Jerome L., Hochman, Judith S., Kunichoff, Dennis F., Anthopolos, Rebecca, Chernyavskiy, Alexander M., Demkow, Marcin, Lopez-Quijano, Juan-Manuel, Escobedo, Jorge, Poh, Kian Keong, Ramos, Ruben B., Lima, Eduardo G., Schuchlenz, Herwig, Ali, Ziad A., Stone, Gregg W., Maron, David J., O'Brien, Sean M., Spertus, John A., and Bangalore, Sripal
- Published
- 2022
- Full Text
- View/download PDF
10. A 600 W Photovoltaic Groundwater Pumping System Based on LLC Converter and Constant Voltage MPPT
- Author
-
Flavio Palmiro, Ruben B. Godoy, Tiago H. d. A. Mateus, and Nicholas D. de Andrade
- Subjects
photovoltaic water pumping ,resonant DC-DC converter ,constant voltage MPPT ,Technology - Abstract
The work consists of the development of a market-friendly 600 W photovoltaic battery-less water pumping system. The system is composed of four 280 Wp solar panels, an auxiliary 10 W solar panel, a three-phase converter and a ½ horsepower (hp) submersible water pump. The electronic stage involves a resonant DC-DC converter in series with a voltage source three-phase inverter. The novelties of this work are related to the use of a resonant DC-DC converter with fixed duty-cycle and frequency for water pumping application, the use of Silicon Carbide Metal-Oxide-Semiconductor Field-Effect Transistors (MOSFETs) for solving converter startup issues, and the use of a constant voltage maximum power tracking (MPPT) algorithm with auxiliary panels. The work displays the design of the converter, simulation and experimental results, discussions, and cost evaluation. The feasibility of the system is studied for the water requirements of a beef cattle farm in Brazil.
- Published
- 2023
- Full Text
- View/download PDF
11. Current Sensorless Based on PI MPPT Algorithms
- Author
-
Moacyr A. G. de Brito, Guilherme M. S. Martines, Anderson S. Volpato, Ruben B. Godoy, and Edson A. Batista
- Subjects
controllers ,MPPT ,reduced cost ,sensorless ,Chemical technology ,TP1-1185 - Abstract
This paper presents novel current sensorless maximum-power point-tracking (MPPT) algorithms based on compensators/controllers and a single-input voltage sensor. The proposed MPPTs eliminate the expensive and noisy current sensor, which can significantly reduce the system cost and retain the advantages of the widely used MPPT algorithms, such as Incremental Conductance (IC) and Perturb and Observe (P&O) algorithms. Additionally, it is verified that the proposed algorithms, especially the proposed Current Sensorless V based on PI, can reach outstanding tracking factors (TFs) such as the IC and P&O based on PI algorithms. In this sense, the insertion of controllers inside the MPPT gives them adaptive characteristics, and the experimental TFs are in the remarkable range of more than 99%, with an average yield of 99.51% and a peak of 99.80%.
- Published
- 2023
- Full Text
- View/download PDF
12. Differential Evolution and Fuzzy-Logic-Based Predictive Algorithm for V2G Charging Stations
- Author
-
Lucas G. da Silva, Nicholas D. de Andrade, Ruben B. Godoy, Moacyr A. G. de Brito, and Emilio T. Maddalena
- Subjects
V2G applications ,differential evolution algorithm ,fuzzy controller ,charging optimization ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
This work proposes a differential evolution algorithm to control a vehicle-to-grid (V2G) system based on photovoltaic generation and energy cost curves, and constraints associated with the power converters’ operation, battery charging strategy, and initial budgets. The algorithm is designed to trade off the batteries’ state of charge and the profits gained from selling energy to the grid. To achieve this balance, a fuzzy controller is employed and acts based on forecasts of the photovoltaic generation and the cost of electricity, within prediction windows of 120 min, adapting the batteries’ rate of charging or discharging. Simulation results show that for different curves and different initial budgets, the target state of charge is reached at the end of the time horizon. By evaluating the proposed scheme under different scenarios, the algorithm’s performance is proven to be suitable for future practical deployment.
- Published
- 2023
- Full Text
- View/download PDF
13. Extending Screening in “Elderly” Patients: Should We Consider a Selective Approach?
- Author
-
Ip, Eugenia C., Cohen-Hallaleh, Ruben B., and Ng, Alexander K.
- Published
- 2020
- Full Text
- View/download PDF
14. Outcomes of Pregnancies Affected by Gestational Diabetes and Type 2 Diabetes in a Rural First Nations Obstetrical Program in Northwest Ontario
- Author
-
Kattini, Ribal, Poirier, Jenna N., Kelly, Len F., Madden, Sharen N., Ockenden, Holly, Dooley, Joseph P., and Hummelen, Ruben B.
- Published
- 2020
- Full Text
- View/download PDF
15. Integrated Starter Alternator PMSM Drive for Hybrid Vehicles
- Author
-
Godoy, Ruben B., de Brito, Moacyr A. G., Garcia, Raymundo C., Kimpara, Marcio L. M., and Pinto, João Onofre P.
- Published
- 2021
- Full Text
- View/download PDF
16. VSG Control Applied to Seven-Level PV Inverter for Partial Shading Impact Abatement
- Author
-
Tiago H. de A. Mateus, José A. Pomilio, Ruben B. Godoy, and João O. P. Pinto
- Subjects
partial shading ,cascaded multilevel inverter ,droop control ,active power transfer ,Technology - Abstract
This paper describes the use of a Cascaded H-Bridge Multilevel Inverter to deal with the problem of partial shading in a photovoltaic system connected to the grid. Combined with the topology, it proposes the use of a virtual synchronous generator for power sharing between photovoltaic arrays and to ensure the connection to the power grid even in extreme shading situations with no power buffer. The experimental results demonstrate the feasibility of the strategy adopted and the limitations to overcome.
- Published
- 2022
- Full Text
- View/download PDF
17. Embedded FPGA Controllers for Current Compensation Based on Modern Power Theories
- Author
-
Nicholas D. de Andrade, Ruben B. Godoy, Edson A. Batista, Moacyr A. G. de Brito, and Rafael L. R. Soares
- Subjects
active parallel power filter ,FPGA-in-the-loop ,modern power theories ,Technology - Abstract
This work compares the performance of two embedded FPGA controllers that can be used in Active Parallel Power Filters (APPF). Both controllers are validated through the FPGA-in-the-loop (FIL) technique, the algorithm’s synthesis is accomplished using the Quartus II® platform, and the board used is from Altera®—Cyclone IV DE2-115. The main difference between the controllers resides in the power theories used to obtain the currents for compensation. The results confirm that the FPGA is a suitable digital device for the parallel operation of multiple compensators and calculation stages, being a viable solution for the requirements imposed in the control of APPF. Furthermore, the effectiveness of the FIL technique for validating the operation of digital circuits and control systems is also confirmed. Finally, a comparison between the processing costs of each of the implemented power theories is presented to guide novel proposals.
- Published
- 2022
- Full Text
- View/download PDF
18. Observational relationships between ammonia, carbon dioxide and water vapor under a wide range of meteorological and turbulent conditions: RITA-2021 campaign.
- Author
-
Schulte, Ruben B., Vilà-Guerau de Arellano, Jordi, Rutledge-Jonker, Susanna, van der Graaf, Shelley, Zhang, Jun, and van Zanten, Margreet C.
- Subjects
CARBON dioxide in water ,WATER vapor ,LAND-atmosphere interactions ,TURBULENT mixing ,WATER pressure ,LATENT heat ,ATMOSPHERIC carbon dioxide ,AMMONIA - Abstract
We present a comprehensive observational approach that aims to establish relationships between the surface–atmosphere exchange of ammonia (NH3) and CO2 uptake and transpiration by vegetation. In doing so, we study relationships useful for the improvement and development of NH3 flux representations in models. The NH3 concentration and flux are measured using a novel open-path miniDOAS (differential optical absorption spectroscopy) measurement setup, taken during the 5-week Ruisdael Land–Atmosphere Interactions Intensive Trace-gas and Aerosol measurement (RITA-2021) campaign (25 August until 12 October 2021) at the Ruisdael Observatory in Cabauw, the Netherlands. After filtering for unobstructed flow, sufficient turbulent mixing and CO2 uptake, we find the diurnal variability in the NH3 flux to be characterized by daytime emissions (0.05 µgm-2s-1 on average) and deposition at sunrise and sunset (-0.05 µgm-2s-1 on average). We first compare the NH3 flux to the observed gross primary production (GPP), representing CO2 uptake, and latent heat flux (LvE), representing net evaporation. Next, we study the observations following the main drivers of the dynamic vegetation response, which are photosynthetically active radiation (PAR), temperature (T) and the water vapor pressure deficit (VPD). Our findings indicate the dominance of the stomatal emission of NH3 , with a high correlation between the observed emissions and both LvE (0.70) and PAR (0.72), as well as close similarities in the diurnal variability in the NH3 flux and GPP. However, efforts to establish relationships are hampered by the high diversity in the NH3 sources of the active agricultural region and the low data availability after filtering. Our findings show the need to collocate meteorological, carbon and nitrogen studies to advance our understanding of NH3 surface exchange and its representation. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
19. Sampling Rate Impact on Electrical Power Measurements Based on Conservative Power Theory
- Author
-
Larissa R. Souza, Ruben B. Godoy, Matheus A. de Souza, Luigi G. Junior, and Moacyr A. G. de Brito
- Subjects
accurate measurements ,Conservative Power Theory ,sampling rate ,Technology - Abstract
This article presents a study of the sampling rate effect on electrical power measurements whose definitions are based on the Conservative Power Theory (CPT). The definitions of active power and reactive power of the CPT were applied in the MATLAB® software by varying the sampling rate and using a digital power meter as a reference. The measurements were performed in scenarios with linear and non-linear loads. Due to the usage of an integral in the CPT calculus, an error was verified associated with the reactive power being inversely proportional to the sampling rate. From the present study, it is possible to conclude that depending on the sample rate, the errors associated with the reactive power measurements are unacceptable and make the CPT implementation unfeasible. The results also presented effective information about the minimal sampling rate needed to make these errors neglected and to assist in choosing suitable microprocessors for the digital implementation of the CPT. It is worth mentioning that this paper was limited to assess how accurate the measurements of active and reactive powers were and important to highlight that the CPT has the additional contribution of dealing with distortion currents and consequently new portions of powers. For the latter, the influence of sampling rate may be crucial and new lines of investigation are motivated.
- Published
- 2021
- Full Text
- View/download PDF
20. A 600 W Photovoltaic Groundwater Pumping System Based on LLC Converter and Constant Voltage MPPT
- Author
-
Andrade, Flavio Palmiro, Ruben B. Godoy, Tiago H. d. A. Mateus, and Nicholas D. de
- Subjects
photovoltaic water pumping ,resonant DC-DC converter ,constant voltage MPPT - Abstract
The work consists of the development of a market-friendly 600 W photovoltaic battery-less water pumping system. The system is composed of four 280 Wp solar panels, an auxiliary 10 W solar panel, a three-phase converter and a ½ horsepower (hp) submersible water pump. The electronic stage involves a resonant DC-DC converter in series with a voltage source three-phase inverter. The novelties of this work are related to the use of a resonant DC-DC converter with fixed duty-cycle and frequency for water pumping application, the use of Silicon Carbide Metal-Oxide-Semiconductor Field-Effect Transistors (MOSFETs) for solving converter startup issues, and the use of a constant voltage maximum power tracking (MPPT) algorithm with auxiliary panels. The work displays the design of the converter, simulation and experimental results, discussions, and cost evaluation. The feasibility of the system is studied for the water requirements of a beef cattle farm in Brazil.
- Published
- 2023
- Full Text
- View/download PDF
21. Cold highly charged ions in a radio-frequency trap with superconducting magnetic shielding
- Author
-
Dijck, Elwin A., Warnecke, Christian, Wehrheim, Malte, Henninger, Ruben B., Eff, Julia, Georgiou, Kostas, Graf, Andrea, Kokh, Stepan, Sajith, Lakshmi P. Kozhiparambil, Mayo, Christopher, Schäfer, Vera M., Volk, Claudia, Schmidt, Piet O., Pfeifer, Thomas, and López-Urrutia, José R. Crespo
- Subjects
Atomic Physics (physics.atom-ph) ,FOS: Physical sciences ,Physics - Atomic Physics - Abstract
We implement sympathetic cooling of highly charged ions (HCI) by fully enclosing a linear Paul trap within a superconducting radio-frequency resonator. A quantization magnetic field applied while cooling down into the superconducting state remains present in the trap for centuries and external electromagnetic fluctuations are greatly suppressed. A magnetic field decay rate at the 10$^{-10}$ s$^{-1}$ level is found using trapped Doppler-cooled Be$^+$ ions as hyperfine-structure (hfs) qubits. Ramsey interferometry and spin-echo measurements on magnetically-sensitive hfs transitions yield coherence times of >400 ms, showing excellent passive shielding at frequencies down to DC. For sympathetic cooling of HCI, we extract them from an electron beam ion trap (EBIT) and co-crystallize one together with Doppler-cooled Be$^+$ ions. By subsequently ejecting all but one Be$^+$ ions, we prepare single HCI for quantum logic spectroscopy towards frequency metrology and qubit operations with a great variety of HCI species., 16 pages, 19 figures. The following article has been submitted to Review of Scientific Instruments. After it is published, it will be found at https://rsi.aip.org/
- Published
- 2023
22. Differential-Evolution-Assisted Optimization of Classical Compensation Topologies for 1 W Current-Fed IMD Wireless Charging Systems.
- Author
-
de Jesus, Ianca M. S., Tolfo, Thaís M., Godoy, Ruben B., Pelzl, Matheus de C., Acosta, Beatriz de S., and Soares, Rafael L. R.
- Subjects
WIRELESS power transmission ,ARTIFICIAL implants ,MEDICAL equipment ,TOPOLOGY ,POWER resources - Abstract
Implantable medical devices (IMDs) necessitate a consistent energy supply, commonly sourced from an embedded battery. However, given the finite lifespan of batteries, periodic replacement becomes imperative. This paper addresses the challenge by introducing a wireless power transfer system designed specifically for implantable medical devices (IMDs). It begins with a detailed analysis of the four conventional topologies. Following this, the paper provides a thorough explanation for choosing the PS topology, highlighting its advantages and suitability for the intended application. The primary parallel capacitance necessitates power from current sources; thus, a Class-E amplifier was implemented. Additionally, the selected circuit was engineered to deliver 1 W at the biocompatible resonance frequency of 13.56 MHz. The delineation of the resonance parameters hinges on multifaceted solutions, encompassing bifurcation-free operation and the attainment of peak efficiency. To ensure the feasibility of the proposed solution, a Differential-Evolution-based algorithm was employed. The results obtained from simulation-based evaluations indicated that the system achieved an efficiency exceeding 86%. This efficiency level was maintained even in the face of frequency fluctuations and variations in the coupling between the coils, thereby ensuring stable operational performance. This aligns seamlessly with the specified application prerequisites, guaranteeing a feasible and reliable operation. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
23. MPPT Híbrido Aplicado à Associação dos Conversores Boost ZVT e Inversor H6 Para Aplicações Fotovoltaicas
- Author
-
Moacyr A. G. de Brito, Marcos G. Alves, Ruben B. Godoy, and Carlos A. Canesin
- Subjects
Boost ZVT ,Energia Fotovoltaica ,Inversor H6 ,MPPT Híbrido ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
Este artigo apresenta um inversor monofásico de 4,8kW para aplicações fotovoltaicas, baseado nos conversores Boost ZVT e inversor H6, para a conexão à rede de distribuição. Devido aos valores nominais de corrente o conversor Boost ZVT traz vantagens, considerando-se reduzida interferência eletromagnética, além de elevada eficiência (acima de 96%), enquanto que o inversor H6 permite o projeto de elementos de conexão com indutância reduzida, além de propiciar baixa variação de nível de tensão de modo comum. No presente artigo, um sistema de MPPT híbrido que pode atuar dependendo do nível da tensão de entrada da associação de painéis é apresentado, podendo o sistema operar com todos os conversores ou apenas com o conversor CC-CA, fato que eleva a eficiência do sistema. Finalmente, resultados e análises são apresentadas, contendo todos os algoritmos necessários à aplicação proposta.
- Published
- 2018
- Full Text
- View/download PDF
24. Sympathetically cooled highly charged ions in a radio-frequency trap with superconducting magnetic shielding.
- Author
-
Dijck, Elwin A., Warnecke, Christian, Wehrheim, Malte, Henninger, Ruben B., Eff, Julia, Georgiou, Kostas, Graf, Andrea, Kokh, Stepan, Kozhiparambil Sajith, Lakshmi P., Mayo, Christopher, Schäfer, Vera M., Volk, Claudia, Schmidt, Piet O., Pfeifer, Thomas, and Crespo López-Urrutia, José R.
- Subjects
MAGNETIC shielding ,MAGNETIC traps ,ION traps ,QUANTUM logic ,QUBITS ,SUPERCONDUCTING transition temperature ,CRYOGENICS - Abstract
We sympathetically cool highly charged ions (HCI) in Coulomb crystals of Doppler-cooled Be
+ ions confined in a cryogenic linear Paul trap that is integrated into a fully enclosing radio-frequency resonator manufactured from superconducting niobium. By preparing a single Be+ cooling ion and a single HCI, quantum logic spectroscopy toward frequency metrology and qubit operations with a great variety of species are enabled. While cooling down the assembly through its transition temperature into the superconducting state, an applied quantization magnetic field becomes persistent, and the trap becomes shielded from subsequent external electromagnetic fluctuations. Using a magnetically sensitive hyperfine transition of Be+ as a qubit, we measure the fractional decay rate of the stored magnetic field to be at the 10−10 s−1 level. Ramsey interferometry and spin-echo measurements yield coherence times of >400 ms, demonstrating excellent passive magnetic shielding at frequencies down to DC. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
25. Observational relationships between ammonia, carbon dioxide and water vapor under a wide range of meteorological and turbulent conditions: RITA-2021 campaign.
- Author
-
Schulte, Ruben B., de Arellano, Jordi Vilà-Guerau, van der Graaf, Shelley, Rutledge-Jonker, Susanna, Jun Zhang, and van Zanten, Margreet C.
- Subjects
CARBON dioxide in water ,WATER vapor ,TURBULENT mixing ,WATER pressure ,VAPOR pressure ,LATENT heat ,AMMONIA - Abstract
We present a comprehensive observational approach, aiming to establish relations between the surface-atmosphere exchange of ammonia (NH3) and the CO2 uptake and transpiration by vegetation. In doing so, we study relationships useful for the the improvement and development of NH3 flux representations and their dependences. The NH
3 concentration and flux are measured using a novel open-path miniDOAS measurement setup, taken during the five week RITA-2021 campaign (25 August until 12 October 2021) at the Ruisdael Observatory at Cabauw, the Netherlands. After filtering for unobstructed flow, sufficient turbulent mixing and CO2 uptake, we find the diurnal variability of the NH3 flux to be characterized by daytime emissions (0.05 µg m-2 s-1 on average) and deposition at sunrise and sunset (-0.05 µg m-2s-1 on average). We first compare the NH3 flux to the observed gross primary production (GPP), representing CO2 uptake, and latent heat flux (LvE), representing to evapotranspiration. Next we study the observations following the main drivers of the dynamic vegetation response, which are photosynthetically active radiation (PAR), temperature (T) and the water vapor pressure deficit (VPD). Our findings show indication of the dominance of stomatal emission of NH3 , with high correlation between the observed emissions and both net LvE (0.70) and PAR (0.72), as well as close similarities in the diurnal variability of the NH3 flux and GPP. However, the efforts to establish relationships are hampered due to the amount of diversity of NH3 sources of the active agricultural region and low data availability after filtering. Our findings show the need to collocate meteorological, carbon and nitrogen studies to advance on our understanding of NH3 deposition and its representation. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
26. A 600 W Photovoltaic Groundwater Pumping System Based on LLC Converter and Constant Voltage MPPT.
- Author
-
Palmiro, Flavio, Godoy, Ruben B., Mateus, Tiago H. d. A., and de Andrade, Nicholas D.
- Subjects
- *
SOLAR pumps , *ON-chip charge pumps , *DC-to-DC converters , *SUBMERSIBLE pumps , *WATER pumps , *FIELD-effect transistors - Abstract
The work consists of the development of a market-friendly 600 W photovoltaic battery-less water pumping system. The system is composed of four 280 Wp solar panels, an auxiliary 10 W solar panel, a three-phase converter and a ½ horsepower (hp) submersible water pump. The electronic stage involves a resonant DC-DC converter in series with a voltage source three-phase inverter. The novelties of this work are related to the use of a resonant DC-DC converter with fixed duty-cycle and frequency for water pumping application, the use of Silicon Carbide Metal-Oxide-Semiconductor Field-Effect Transistors (MOSFETs) for solving converter startup issues, and the use of a constant voltage maximum power tracking (MPPT) algorithm with auxiliary panels. The work displays the design of the converter, simulation and experimental results, discussions, and cost evaluation. The feasibility of the system is studied for the water requirements of a beef cattle farm in Brazil. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
27. LB909 Incisional biopsy: A highly effective treatment for keratoacanthoma?
- Author
-
Vitcov, G.G., Bridgewater, M., Ruben, B., Abegaze, B.H., and Ghadially, R.
- Published
- 2024
- Full Text
- View/download PDF
28. A Robustness Analysis of a Fuzzy Fractional Order PID Controller Based on Genetic Algorithm for a DC-DC Boost Converter
- Author
-
Luís Felipe da S. C. Pereira, Edson Batista, Moacyr A. G. de Brito, and Ruben B. Godoy
- Subjects
boost DC-DC converter ,fractional order PID controller ,fuzzy logic controller ,genetic algorithm ,Computer Networks and Communications ,Hardware and Architecture ,Control and Systems Engineering ,Signal Processing ,Electrical and Electronic Engineering - Abstract
In this paper, a new topology of a Fractional Order PID (FOPID) controller is proposed to control a boost DC-DC converter with minimum over/undershoot. The fractional controller parameters are tuned using a genetic algorithm (GA) with a combined cost function composed of the Integral of Time-Weighted Absolute Error (ITAE) and the Integral of Time-Weighted Square Error (ITSE). Despite adding moderate complexity to the control structure, the simulation results reveal that the GA-based FOPID controller tuning provided better performance for the setpoint tracking both under load variations and parameters deviation due to the prolonged use. The proposed FOPID shows a wide operational range concerning load disturbances, and capacitance/inductance deviations of ±30% and ±50% from nominal values, achieving functionality and voltage stability even with output power 50% higher than the converter power specification. The assessment was made considering operation in voltage mode and the performance was compared to conventional Proportional-Integral (PI), Type II and current mode controllers. Finally, a fuzzy fractional-order PID (FFOPID) was designed to outperform the FOPID during disturbances in the control variable.
- Published
- 2022
- Full Text
- View/download PDF
29. An efficient transformation method for genome editing of elite bread wheat cultivars.
- Author
-
Biswal, Akshaya K., Hernandez, L. Ruben B., Castillo, Ana I. R., Debernardi, Juan M., and Dhugga, Kanwarpal S.
- Abstract
An efficient genetic transformation protocol is necessary to edit genes for trait improvement directly in elite bread wheat cultivars. We used a protein fusion between a wheat growth-regulating factor 4 (GRF4) and its interacting factor (GIF1) to develop a reproducible genetic transformation and regeneration protocol, which we then used to successfully transform elite bread wheat cultivars Baj, Kachu, Morocco, Reedling, RL6077, and Sujata in addition to the experimental cultivar Fielder. Immature embryos were transformed with the vector using particle bombardment method. Transformation frequency increased nearly 60-fold with the GRF4-GIF1-containing vectors as compared to the control vector and ranged from ~5% in the cultivar Kachu to 13% in the cultivar RL6077. We then edited two genes that confer resistance against leaf rust and powdery mildew directly in the aforementioned elite cultivars. A wheat promoter, TaU3 or TaU6, to drive the expression of guide RNA was effective in gene editing whereas the OsU3 promoter failed to generate any edits. Editing efficiency was nearly perfect with the wheat promoters. Our protocol has made it possible to edit genes directly in elite wheat cultivars and would be useful for gene editing in other wheat varieties, which have been recalcitrant to transformation thus far. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
30. Current Sensorless Based on PI MPPT Algorithms.
- Author
-
de Brito, Moacyr A. G., Martines, Guilherme M. S., Volpato, Anderson S., Godoy, Ruben B., and Batista, Edson A.
- Subjects
ALGORITHMS ,TRACKING algorithms ,VOLTAGE ,DETECTORS - Abstract
This paper presents novel current sensorless maximum-power point-tracking (MPPT) algorithms based on compensators/controllers and a single-input voltage sensor. The proposed MPPTs eliminate the expensive and noisy current sensor, which can significantly reduce the system cost and retain the advantages of the widely used MPPT algorithms, such as Incremental Conductance (IC) and Perturb and Observe (P&O) algorithms. Additionally, it is verified that the proposed algorithms, especially the proposed Current Sensorless V based on PI, can reach outstanding tracking factors (TFs) such as the IC and P&O based on PI algorithms. In this sense, the insertion of controllers inside the MPPT gives them adaptive characteristics, and the experimental TFs are in the remarkable range of more than 99%, with an average yield of 99.51% and a peak of 99.80%. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
31. Differential Evolution and Fuzzy-Logic-Based Predictive Algorithm for V2G Charging Stations.
- Author
-
da Silva, Lucas G., de Andrade, Nicholas D., Godoy, Ruben B., de Brito, Moacyr A. G., and Maddalena, Emilio T.
- Subjects
DIFFERENTIAL evolution ,ALGORITHMS ,ENERGY industries ,BUDGET ,PHOTOVOLTAIC power systems ,TIME perspective - Abstract
This work proposes a differential evolution algorithm to control a vehicle-to-grid (V2G) system based on photovoltaic generation and energy cost curves, and constraints associated with the power converters' operation, battery charging strategy, and initial budgets. The algorithm is designed to trade off the batteries' state of charge and the profits gained from selling energy to the grid. To achieve this balance, a fuzzy controller is employed and acts based on forecasts of the photovoltaic generation and the cost of electricity, within prediction windows of 120 min, adapting the batteries' rate of charging or discharging. Simulation results show that for different curves and different initial budgets, the target state of charge is reached at the end of the time horizon. By evaluating the proposed scheme under different scenarios, the algorithm's performance is proven to be suitable for future practical deployment. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
32. A Polymorph of Dipeptide Halide Glycyl-L-Alanine Hydroiodide Monohydrate: Crystal Structure, Optical Second Harmonic Generation, Piezoelectricity and Pyroelectricity.
- Author
-
Baptista, Rosa M. F., Gomes, Clara S. B., Silva, Bruna, Oliveira, João, Almeida, Bernardo, Castro, Cidália, Rodrigues, Pedro V., Machado, Ana, Freitas, Ruben B., Rodrigues, Manuel J. L. F., de Matos Gomes, Etelvina, and Belsley, Michael
- Subjects
SECOND harmonic generation ,POLYMORPHISM (Crystallography) ,CRYSTAL structure ,PYROELECTRICITY ,PIEZOELECTRICITY ,TRIGLYCINE sulfate - Abstract
A polymorph of glycyl-L-alanine HI.H
2 O is synthesized from chiral cyclo-glycyl-L-alanine dipeptide. The dipeptide is known to show molecular flexibility in different environments, which leads to polymorphism. The crystal structure of the glycyl-L-alanine HI.H2 O polymorph is determined at room temperature and indicates that the space group is polar (P21 ), with two molecules per unit cell and unit cell parameters a = 7.747 Å, b = 6.435 Å, c = 10.941 Å, α = 90°, β = 107.53(3)°, γ = 90° and V = 520.1(7) Å3 . Crystallization in the polar point group 2, with one polar axis parallel to the b axis, allows pyroelectricity and optical second harmonic generation. Thermal melting of the glycyl-L-alanine HI.H2 O polymorph starts at 533 K, close to the melting temperature reported for cyclo-glycyl-L-alanine (531 K) and 32 K lower than that reported for linear glycyl-L-alanine dipeptide (563 K), suggesting that although the dipeptide, when crystallized in the polymorphic form, is not anymore in its cyclic form, it keeps a memory of its initial closed chain and therefore shows a thermal memory effect. Here, we report a pyroelectric coefficient as high as 45 µC/m2 K occurring at 345 K, one order of magnitude smaller than that of semi-organic ferroelectric triglycine sulphate (TGS) crystal. Moreover, the glycyl-L-alanine HI.H2 O polymorph displays a nonlinear optical effective coefficient of 0.14 pm/V, around 14 times smaller than the value from a phase-matched inorganic barium borate (BBO) single crystal. The new polymorph displays an effective piezoelectric coefficient equal to d e f f = 280 p C N − 1 , when embedded into electrospun polymer fibers, indicating its suitability as an active system for energy harvesting. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
33. Affluence and Influence in a Social Democracy.
- Author
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MATHISEN, RUBEN B.
- Subjects
- *
SOCIAL democracy , *SOCIAL influence , *WEALTH , *RICH people , *EQUALITY , *PUBLIC opinion - Abstract
Research from the United States and Europe suggests that affluent citizens enjoy considerably more policy influence than do average citizens and the poor. I examine the extent of unequal policy responsiveness in one of the countries that have gone farthest in reducing economic inequality and restricting money in politics: Norway. I use an original dataset on public opinion and public policy containing 603 specific issues over five decades (1966–2014). The results show that although policy is certainly skewed toward the preferences of the privileged, Norway stands out among previously studied cases for two reasons: (1) The preferences of the poor seem to have some sway on economic issues and (2) not all affluent citizens get their way: educational attainment appears to be the more important determinant. The Norwegian case suggests that influence need not be as dependent upon affluence as in the United States. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
34. Extracellular loops matter – subcellular location and function of the lysine transporter Lyp1 from Saccharomyces cerevisiae
- Author
-
Ruben B. Doorn, Mirco Lorenzon, Christiaan M. Punter, Joury S van 't Klooster, Jarnick Lusseveld, Frans Bianchi, Bert Poolman, Enzymology, Molecular Immunology, and Groningen Biomolecular Sciences and Biotechnology
- Subjects
0301 basic medicine ,Models, Molecular ,Saccharomyces cerevisiae Proteins ,membrane transport ,Saccharomyces cerevisiae ,yeast ,Biochemistry ,03 medical and health sciences ,0302 clinical medicine ,Extracellular ,Molecular Biology ,chemistry.chemical_classification ,Alanine ,biology ,Lysine ,Computational Biology ,loop ,Cell Biology ,Original Articles ,Membrane transport ,biology.organism_classification ,APC superfamily ,Amino acid ,Transmembrane domain ,Kinetics ,030104 developmental biology ,chemistry ,030220 oncology & carcinogenesis ,Symporter ,Biophysics ,Amino Acid Transport Systems, Basic ,Original Article ,Intracellular ,amino acid - Abstract
Yeast amino acid transporters of the APC superfamily are responsible for the proton motive force‐driven uptake of amino acids into the cell, which for most secondary transporters is a reversible process. The l‐lysine proton symporter Lyp1 of Saccharomyces cerevisiae is special in that the Michaelis constant from out‐to‐in transport ( Kmout→in ) is much lower than Kmin→out , which allows accumulation of l‐lysine to submolar concentration. It has been proposed that high intracellular lysine is part of the antioxidant mechanism of the cell. The molecular basis for the unique kinetic properties of Lyp1 is unknown. We compared the sequence of Lyp1 with APC para‐ and orthologues and find structural features that set Lyp1 apart, including differences in extracellular loop regions. We screened the extracellular loops by alanine mutagenesis and determined Lyp1 localization and activity and find positions that affect either the localization or activity of Lyp1. Half of the affected mutants are located in the extension of extracellular loop 3 or in a predicted α‐helix in extracellular loop 4. Our data indicate that extracellular loops not only connect the transmembrane helices but also serve functionally important roles., We performed alanine‐scanning mutagenesis of the extracellular loops of the yeast lysine transporter Lyp1. We find positions that affect either the localization or activity of Lyp1. Half of the affected mutants are located in the extension of extracellular loop 3 or in a predicted α‐helix in extracellular loop 4. We conclude that extracellular loops of amino acid transporters of the APC superfamily serve functionally important roles.
- Published
- 2020
35. DLR Results for the First AIAA Stability and Control Prediction Workshop
- Author
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Ruben B. Seidler, Andreas Rene R. Huebner, and Markus Widhalm
- Subjects
Aerodynamics ,Stability and Control ,Computational Fluid Dynamics ,Derivative Prediction ,Workshop ,Common Research Model - Published
- 2022
- Full Text
- View/download PDF
36. Assessing the representativity of NH3 measurements influenced by boundary-layer dynamics and the turbulent dispersion of a nearby emission source
- Author
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Schulte, Ruben B., Zanten, Margreet C., Stratum, Bart J. H., and Vilà-Guerau de Arellano, Jordi
- Subjects
Meteorologie en Luchtkwaliteit ,WIMEK ,Meteorology ,Meteorology and Air Quality ,Life Science ,Meteorologie - Abstract
This study presents a fine-scale simulation approach to assess the representativity of ammonia (NH3) measurements in the proximity of an emission source. Close proximity to emission sources (< 5 km) can introduce a bias in regionally representative measurements of the NH3 molar fraction and flux. Measurement sites should, therefore, be located a significant distance away from emission sources, but these requirements are poorly defined and can be difficult to meet in densely agricultural regions. This study presents a consistent criterion to assess the regional representativity of NH3 measurements in proximity to an emission source, calculating variables that quantify the NH3 plume dispersion using a series of numerical experiments at a fine resolution (20 m). Our fine-scale simulation framework with explicitly resolved turbulence enables us to distinguish between the background NH3 and the emission plume, including realistic representations of NH3 deposition and chemical gas–aerosol transformations. We introduce the concept of blending distance based on the calculation of turbulent fluctuations to systematically analyze the impact of the emission plume on simulated measurements, relative to this background NH3. We perform a suite of systematic numerical experiments for flat homogeneous grasslands, centered around the CESAR Observatory at Cabauw, to analyze the sensitivity of the blending distance, varying meteorological factors, emission/deposition and NH3 dependences. Considering these sensitivities, we find that NH3 measurements at this measurement site should be located at a minimum distance of 0.5–3.0 and 0.75–4.5 km from an emission source for NH3 molar fraction and flux measurements, respectively. The simulation framework presented here can easily be adapted to local conditions, and paves the way for future ammonia research to integrate simulations at high spatio-temporal resolutions with observations of NH3 concentrations and fluxes.
- Published
- 2022
37. Maps of Battles, Battle of Maps: News Cartography of the Battle at Neerwinden, Flanders, 1693
- Author
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Van Luijk, Ruben B.
- Published
- 2008
- Full Text
- View/download PDF
38. Microcalcifications in Early Intimal Lesions of Atherosclerotic Human Coronary Arteries
- Author
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Roijers, Ruben B., Debernardi, Nicola, Cleutjens, Jack P.M., Schurgers, Leon J., Mutsaers, Peter H.A., and van der Vusse, Ger J.
- Published
- 2011
- Full Text
- View/download PDF
39. Assessing representativity of NH3 measurements influenced by boundary-layer dynamics and turbulent dispersion of a nearby emission source
- Author
-
Schulte, Ruben B., Zanten, Margreet C., and Vilà-Guerau de Arellano, Jordi
- Abstract
This study presents a fine scale simulation approach to assess the representativity of ammonia (NH3) measurements in proximity of an emission source. Close proximity to emission sources (3 molar fraction and flux. Measurement sites should therefore be located a significant distance from emission sources, but such requirements are poorly defined and can be difficult to meet in densely agricultural regions. This study presents a consistent criterium to assess the regional representativity of NH3 measurements in proximity of an emission source, calculating variables that quantify the NH3 plume dispersion using a series of numerical experiments at a fine resolution (20 m). Our fine scale simulation framework with explicitly resolved turbulence enables us to distinguish between the background NH3 and the emission plume, including realistic representations of NH3 deposition and chemical gas-aerosol transformations. We introduce the concept of blending-distance, based on the calculation of turbulent fluctuations, to systematically analyze the impact of the emission plume on simulated measurements, relative to this background NH3. This sensitivity analysis includes systematic experiments varying meteorological factors, emission/deposition and NH3 dependences. Considering these sensitivities, we find that NH3 measurements should be located at a minimum distance of 0.5–2.5 km and 1–3.5 km from an emission source, for NH3 molar fraction and flux measurements respectively. The simulation framework presented here can easily be adapted to local conditions and paves the way for future ammonia research at high spatio-temporal resolution.
- Published
- 2021
40. Intra-Section Analysis of Human Coronary Arteries Reveals a Potential Role for Micro-Calcifications in Macrophage Recruitment in the Early Stage of Atherosclerosis.
- Author
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Martijn L L Chatrou, Jack P Cleutjens, Ger J van der Vusse, Ruben B Roijers, Peter H A Mutsaers, and Leon J Schurgers
- Subjects
Medicine ,Science - Abstract
Vascular calcification is associated with poor cardiovascular outcome. Histochemical analysis of calcification and the expression of proteins involved in mineralization are usually based on whole section analysis, thereby often ignoring regional differences in atherosclerotic lesions. At present, limited information is available about factors involved in the initiation and progression of atherosclerosis.This study investigates the intra-section association of micro-calcifications with markers for atherosclerosis in randomly chosen section areas of human coronary arteries. Moreover, the possible causal relationship between calcifying vascular smooth muscle cells and inflammation was explored in vitro.To gain insights into the pathogenesis of atherosclerosis, we performed analysis of the distribution of micro-calcifications using a 3-MeV proton microbeam. Additionally, we performed systematic analyses of 30 to 40 regions of 12 coronary sections obtained from 6 patients including histology and immuno-histochemistry. Section areas were classified according to CD68 positivity. In vitro experiments using human vascular smooth muscle cells (hVSMCs) were performed to evaluate causal relationships between calcification and inflammation.From each section multiple areas were randomly chosen and subsequently analyzed. Depositions of calcium crystals at the micrometer scale were already observed in areas with early pre-atheroma type I lesions. Micro-calcifications were initiated at the elastica interna concomitantly with upregulation of the uncarboxylated form of matrix Gla-protein (ucMGP). Both the amount of calcium crystals and ucMGP staining increased from type I to IV atherosclerotic lesions. Osteochondrogenic markers BMP-2 and osteocalcin were only significantly increased in type IV atheroma lesions, and at this stage correlated with the degree of calcification. From atheroma area type III onwards a considerable number of CD68 positive cells were observed in combination with calcification, suggesting a pro-inflammatory effect of micro-calcifications. In vitro, invasion assays revealed chemoattractant properties of cell-culture medium of calcifying vascular smooth muscle cells towards THP-1 cells, which implies pro-inflammatory effect of calcium deposits. Additionally, calcifying hVSMCs revealed a pro-inflammatory profile as compared to non-calcifying hVSMCs.Our data indicate that calcification of VSMCs is one of the earliest events in the genesis of atherosclerosis, which strongly correlates with ucMGP staining. Our findings suggest that loss of calcification inhibitors and/or failure of inhibitory capacity is causative for the early precipitation of calcium, with concomitant increased inflammation followed by osteochondrogenic transdifferentiation of VSMCs.
- Published
- 2015
- Full Text
- View/download PDF
41. Fuzzy Demand Estimation as Basis of an Assistant Tool for a Strategic Load Management of PHEV
- Author
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Cordeiro, Raimundo, Pinto, João O. P., Godoy, Ruben B., Suemitsu, Walter I., Ribeiro, Pedro Eugênio M. J., and Cerchiari, Sérgio C.
- Published
- 2013
- Full Text
- View/download PDF
42. Eh Status of Lake Sediment-Water Systems in Relation to Nitrogen Transformations
- Author
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Graetz, Donald A., Keeney, Dennis R., and Aspiras, Ruben B.
- Published
- 1973
43. Unraveling the diurnal atmospheric ammonia budget of a prototypical convective boundary layer
- Author
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D. P. J. Swart, M.C. van Zanten, Ruben B. Schulte, S. Rutledge-Jonker, J. Vilà-Guerau de Arellano, Maarten Krol, W.A.J. van Pul, and R.J. Wichink Kruit
- Subjects
Meteorologie en Luchtkwaliteit ,Atmospheric Science ,010504 meteorology & atmospheric sciences ,Meteorology and Air Quality ,Planetary boundary layer ,Modeling. measurements ,010501 environmental sciences ,Luchtkwaliteit ,Atmospheric sciences ,01 natural sciences ,Convective Boundary Layer ,Air Quality ,Troposphere ,Meteorology ,Diurnal cycle ,Ammonia ,Meteorologie ,0105 earth and related environmental sciences ,General Environmental Science ,Convective boundary layer ,WIMEK ,Advection ,Differential optical absorption spectroscopy ,Boundary layer ,Diurnal variability ,Environmental science ,Budget ,Entrainment (chronobiology) - Abstract
We investigate diurnal variability of the atmospheric ammonia (NH3) budget over unfertilized grassland by combining observations with a conceptual atmospheric boundary layer model. Our combined approach of diurnal observations and modeling enables us to identify the contribution of the four governing processes to the NH3 diurnal cycle: surface-atmosphere exchange, entrainment, advection and chemical gas-aerosol transformations. The observations contain new NH3 flux and molar fraction measurements obtained using the Differential Optical Absorption Spectroscopy (DOAS) remote sensing technique, eliminating problems related to inlet tubing. Using strict filter criteria, 22 days with clear-sky summer conditions are selected. From this selection, we analyze a single representative day characterized by prototypical convective boundary layer conditions, using the boundary layer model constrained by meteorological observations. We design two numerical experiments to study the NH3 diurnal variability and the individual contributions of the processes governing the ammonia budget. These experiments only differ in their representation of the NH3 surface exchange. First, a fitted function through the observed NH3 flux is prescribed to the model. In the second numerical experiment, the surface flux is solved following the DEPosition of Acidifying Compounds (DEPAC) parameterization. With a prescribed surface flux, the modeled NH3 molar fraction closely fits the observations. Two regimes are identified in the NH3 diurnal cycle: the morning, where boundary layer dynamics dominate the budget through entrainment, and the afternoon, where multiple processes are of importance. A similarly close fit to the observed molar fraction is achieved in the second experiment, but we identify a mismatch between the observed and parameterized NH3 surface flux. As a result, the model requires an unrealistic budget representation to achieve this close fit, e.g. high free tropospheric NH3. Our findings on the NH3 budget, based on integrating modeling and observations, paves the way for future research on the NH3 surface-atmosphere exchange at the subdaily scales.
- Published
- 2021
44. Performing Dynamic Manipulation of a Rolling Object on the Butterfly Robot with Perturbation in System Parameters
- Author
-
Brecke, Ruben B. and Shiriaev, Anton
- Abstract
En av de vanskeligste aspektene ved ˚a reprodusere menneskelig atferd i robotikk er ˚a utføre ikke-prehensile (ikke-gripende) objektmanipulering. Dersom roboter skal kunne integreres i en menneskeskapt verden, m˚a de være i stand til ˚a utføre slike komplekse aktiviteter. Denne oppgaven tar sikte p˚a ˚a introdusere en ny stabiliserende kontroller til Sommerfugl roboten gitt at den transverse lineariserte dynamikken er funnet. Systemet best˚aende av en ˚atteformet ramme med en ball som rullet p˚a toppen ble foresl˚att som et standardeksempel for utvikling av nye teknikker innen ikke-prehensil manipulasjon. Mens tidligere stabiliseringsmetoder er avhengig av en lineær nominell kontroller basert p˚a stabiliserende løsningen av den periodiske Ricatti differensialligningen (PRDE), vil denne oppgaven introdusere en ”sliding mode control” for ˚a h˚andtere uunng˚aelige forstyrrelser i systemet. Arbeidet presentert i denne oppgaven bruker en ”virtual holonomic constraint” tilnærming. Her brukes en skalar-variabel kjent som en bevegelsesgenerator i et geometrisk forhold kjent som en virtual holonomic constraint for ˚a redusere systemets kompleksitet ved ˚a holde den geometriske relasjonen uforanderlig gjennom en feedback kontroller. Den nominelle banen for det ulineære systemet kan deretter avledes ut fra dynamikken til bevegelsesgeneratoren. Stabiliseringsmetoden bruker den velkjente ekvivalensen mellom et uineært systems lokale, stabile oppførsel og dets lineariserte systems lokale, stabile oppførsel. Et sett med transverse koordinater hvis opprinnelse tilsvarer den nominelle banen, kan deretter lineariseres og stabiliseres ved hjelp av en feedback regulator slik at det resulterende ulineære systemet ogs˚a blir stabilisert. P˚a grunnlag av den transverse lineariseringen vil det utformes to alternative sliding mode kontrollere. Den første metoden er enklere og er basert p˚a Lyapunov-teori, der det vil bli etablert kontrollov som muliggjør en endelig tidskonvergens mot en s˚akalt glidende overflate (som samsvarer med den nominelle oppførselen). For den andre teknikken vil det opprettes et reelt ”subspace” av det lineariserte systemet før dens ”annihilator”, hvis samdimensjoner tilsvarer antall kontrollinnganger, brukes i en svitchfunksjon for kontrolleren. Fordi begge metodene bruker PRDEs stabiliserende løsning, vil ”semi-definite” programmering brukes til ˚a finne en tilnærming. Det ble p˚avist at den første metoden raskt konvergerte mot den nominelle banen for nominelle systemparametere ved numeriske simuleringer, mens for de forstyrrede parametrene viste en betydelig stasjonær feil, men likevel konvergerte mot banen. Den andre metoden resulterte ikke i noen vellykket stabilisering, som var forventet gitt at det ikke ble funnet et subspace som oppfylte de nødvendige betingelsene One of the most challenging aspects of reproducing human behavior in robotics is performing non-prehensile (non-gripping) object manipulation. Robots must be able to move and perform complex activities if they are to be integrated into a human-built world. This paper aims to introduce a new stabilizing controller to the Butterfly Robot, given that the transverse linearized dynamics have been found. The system consisting of a figure eightshaped frame with a ball rolling on top was proposed as a benchmark example for developing new techniques within the field of non-prehensile manipulation. While previous stabilizing methods rely on a linear nominal feedback controller based on the stabilizing solution of the periodic Ricatti differential equation (PRDE), this paper will introduce a sliding mode controller to deal with unavoidable perturbations of the system. The work presented in this paper uses the virtual holonomic constraint approach. Here, a scalar variable known as a motion generator is utilized in a geometric relation known as a virtual holonomic constraint to reduce the system’s complexity by keeping the geometric relation invariant through a feedback controller. The nominal trajectory for the nonlinear system can then be derived based on the dynamics of the motion generator. The stabilization method makes use of the well-known equivalence between a nonlinear system’s local, stable behavior and its linearized system’s local, stable behavior. A set of transverse coordinates whose origin corresponds to the nominal trajectory can then be linearized and stabilized using a feedback controller such that its resulting nonlinear system will be stabilized as well. Based on the transverse linearization, two alternative sliding mode controller architectures will be designed. The first method is simpler and is based on Lyapunov theory. A control law will be established that enables finite-time convergence towards a so-called sliding surface (that matches the nominal behavior). For the second technique, a real invariant subspace of the linearization will be created before its annihilator, whose co-dimensions equals the number of control input, is used in a switching function for the controller. Because both methods use the PRDE’s stabilizing solution, semi-definite programming will be used to find an approximation. The first method was proven to swiftly converge towards the nominal trajectory for nominal system parameters by numerical simulations. In contrast, the perturbed parameters showed a considerable stationary error but still converged towards the trajectory. The second method did not result in any successful stabilization, which was expected given that the found subspace failed to satisfy the required conditions, motivating for further work.
- Published
- 2021
45. High-resolution 3D X-ray imaging of intracranial nitinol stents
- Author
-
Snoeren, Rudolph M., Söderman, Michael, Kroon, Johannes N., Roijers, Ruben B., de With, Peter H. N., and Babic, Drazenko
- Published
- 2012
- Full Text
- View/download PDF
46. Psoriasis restricted to the nail in a 7-year-old child. Should biologics be an appropriate treatment modality when considering quality of life?
- Author
-
Holzberg, M., Ruben, B. S., and Baran, R.
- Published
- 2014
- Full Text
- View/download PDF
47. Embedded FPGA Controllers for Current Compensation Based on Modern Power Theories.
- Author
-
de Andrade, Nicholas D., Godoy, Ruben B., Batista, Edson A., de Brito, Moacyr A. G., and Soares, Rafael L. R.
- Subjects
- *
DIGITAL control systems , *ELECTRIC power filters , *JOB performance - Abstract
This work compares the performance of two embedded FPGA controllers that can be used in Active Parallel Power Filters (APPF). Both controllers are validated through the FPGA-in-the-loop (FIL) technique, the algorithm's synthesis is accomplished using the Quartus II® platform, and the board used is from Altera®—Cyclone IV DE2-115. The main difference between the controllers resides in the power theories used to obtain the currents for compensation. The results confirm that the FPGA is a suitable digital device for the parallel operation of multiple compensators and calculation stages, being a viable solution for the requirements imposed in the control of APPF. Furthermore, the effectiveness of the FIL technique for validating the operation of digital circuits and control systems is also confirmed. Finally, a comparison between the processing costs of each of the implemented power theories is presented to guide novel proposals. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
48. VSG Control Applied to Seven-Level PV Inverter for Partial Shading Impact Abatement.
- Author
-
Mateus, Tiago H. de A., Pomilio, José A., Godoy, Ruben B., and Pinto, João O. P.
- Subjects
SYNCHRONOUS generators ,PHOTOVOLTAIC power systems ,ELECTRIC power distribution grids ,PHOTOVOLTAIC power generation ,TORQUE control - Abstract
This paper describes the use of a Cascaded H-Bridge Multilevel Inverter to deal with the problem of partial shading in a photovoltaic system connected to the grid. Combined with the topology, it proposes the use of a virtual synchronous generator for power sharing between photovoltaic arrays and to ensure the connection to the power grid even in extreme shading situations with no power buffer. The experimental results demonstrate the feasibility of the strategy adopted and the limitations to overcome. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
49. Early calcifications in human coronary arteries as determined with a proton microprobe
- Author
-
Roijers, Ruben B., Dutta, Raj K., Cleutjens, Jack P.M., Mutsaers, Peter H.A., de Goeij, Jeroen J.M., and van der Vusse, Ger J.
- Subjects
Coronary arteries -- Chemical properties ,Calcification -- Research ,Atherosclerosis -- Research ,Chemistry - Abstract
The current paradigm reads that calcifications characterize the advanced and complex lesions in the atherosclerotic process. To explore the possibility that coronary artery wall calcifications already commence at an early stage of atherosclerosis, a combination of proton beam techniques with a (sub-) micrometer resolution, i.e., micro-proton induced X-ray emission, backward and forward scattering spectroscopy, was applied on human coronary arteries with lesions preceding overt atheromas. The detection limits of phosphorus and calcium in each separate pixel, 0.88 * 0.88 [micro][m.sup.2] in size, were approximately 150 and 80 [micro]/g dry weight, respectively. Calcium distributions of entire coronary artery cross section were obtained, and calcifications were demonstrated at a preatheroma stage of the atherosclerotic process. The size of the microcalcifications varied between 1 and 10 [micro]m. The composition of the microcalcifications was deduced from the calcium-to-phosphorus ratio. In order to quantify this ratio, the thickness of the specific X-ray absorber used for PIXE had to be accurately determined. Also, thick target PIXE calculations were performed and the method was validated. The calcium-to-phosphorus ratios of the microcalcifications were assessed with good accuracy and varied from 1.62 to 2.79, which corresponds with amorphous calcium phosphate.
- Published
- 2008
50. Chemically patterned flat stamps for microcontact printing
- Author
-
Sharpe, Ruben B. A., Poelsema, Bene, Burdinski, Dirk, Huskens, Jurriaan, Zandvliet, Harold J. W., and Reinhoudt, David N.
- Subjects
Dimethylpolysiloxane -- Mechanical properties ,Oxidation-reduction reaction -- Research ,Chemistry - Abstract
The problem of mechanical instability and poor barrier properties of relief stamps for microcontact printing (muCP) is addressed by developing new stamp designs. It is shown that the local oxidation of flat PDMS stamps and their subsequent modification with perfluoroalkyl groups is an effective route to solve these problems without compromising intrinsic advantages of the technique which include ease of use and the potential for a high cost efficiency.
- Published
- 2005
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